CN108042558B - Abamectin preparation for aquaculture and preparation method thereof - Google Patents
Abamectin preparation for aquaculture and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Abstract
The invention discloses an abamectin preparation for aquaculture, which comprises the following components in parts by weight: 1-5 parts of abamectin, 1-10 parts of tannic acid, 1-30 parts of an organic solvent, 1-30 parts of a surfactant and 25-96 parts of water. The abamectin preparation for aquaculture can kill parasites efficiently and prevent secondary infection of wounds caused by the parasites effectively; can also be uniformly dispersed in the culture water body, avoids overhigh local concentration and greatly reduces the toxic and side effects of effective components and solvents; greatly reduces the use amount of organic solvent, cost and pollution; the preparation method is simple and easy to operate, and the production equipment only needs a common temperature control reaction kettle.
Description
Technical Field
The invention belongs to the technical field of aquaculture, and particularly relates to an abamectin preparation for aquaculture and a preparation method thereof.
Background
Currently, the occurrence of parasite and bacteria and virus-induced diseases of aquaculture animals causes great economic loss to aquaculture industry. Sinergasilliasis, lernaea, ichthyophthirius multifiliis, dactylogyrus and other common parasitic pathogens for aquaculture, and the damage is extremely large. In the fishery insecticide, the medicaments such as dichlorvos, malachite green and the like are eliminated due to poor safety, environmental pollution and harm to human health, and although the botanical fishery insecticide is used for preventing and treating aquatic animal diseases, the botanical fishery insecticide has the defects of large usage amount, slow effect, incomplete killing effect, high cost and the like. The avermectin is a macrolide antiparasitic drug produced by the avermitilis, has strong expelling and killing effects on nematodes, sinergsilus and lernaea, and is widely applied to the prevention and treatment of in-vivo and in-vitro parasites of aquatic animals. However, most of the existing avermectin insecticides are avermectin with a single component or avermectin and other insecticide compound insecticides, and the insecticides have the following disadvantages: benzene is used as a solvent, and is a pesticide type emulsifiable concentrate pesticide, so that the environment is greatly influenced, the crop residue and toxic and side effects are large, and the parasite is easy to generate drug resistance after long-term use, thereby influencing the healthy development of the aquatic product industry in China.
Disclosure of Invention
The invention provides an abamectin preparation for aquaculture and a preparation method thereof, which can efficiently kill parasites and effectively prevent secondary infection of wounds caused by the parasites; can also be uniformly dispersed in the culture water body, avoids overhigh local concentration and greatly reduces the toxic and side effects of effective components and solvents.
In order to solve the technical problems, the invention adopts a technical scheme that an abamectin preparation for aquaculture is provided, and comprises the following components in parts by weight: 1-5 parts of abamectin, 1-10 parts of tannic acid, 1-30 parts of an organic solvent, 1-30 parts of a surfactant and 25-96 parts of water.
Preferably, the organic solvent is selected from one or more of ethanol, methanol, polyethylene glycol and N, N-dimethylformamide.
Preferably, the surfactant is selected from one or more of dodecyl dimethyl betaine, cocamidopropyl betaine, calcium dodecyl benzene sulfonate, sodium dodecyl sulfate, tween 80, hydroxyethyl cellulose and styryl phenol polyoxyethylene ether.
Preferably, the abamectin preparation for aquaculture comprises, by weight, 1 part of abamectin, 5 parts of tannic acid, 10 parts of N, N-dimethylformamide, 10 parts of ethanol, 10 parts of calcium dodecylbenzene sulfonate, 10 parts of styrylphenol polyoxyethylene ether and 54 parts of water.
The invention also provides a preparation method of the abamectin preparation for aquaculture, which comprises the following steps:
step S1: adding 1-30 parts of organic solvent into a reaction kettle according to parts by weight;
step S2: adding 1-5 parts of abamectin, 1-10 parts of tannic acid and 1-30 parts of surfactant into the organic solvent, and stirring to obtain a mixed solution;
step S3: and adding 25-96 parts by weight of water into the mixed solution, and uniformly stirring to obtain the abamectin preparation for aquaculture.
Preferably, in step S2: stirring the mixture for 10 to 30 minutes by using a stirrer with the rotating speed of 100 to 200 revolutions per minute.
Preferably, in step S3: stirring the mixture for 20 to 40 minutes by using a stirrer with the rotating speed of 100 to 200 revolutions per minute.
Preferably, in the step S2 and the step S3, the reaction temperature of the reaction kettle is 40 ℃ to 45 ℃.
Preferably, the organic solvent is selected from one or more of ethanol, methanol, polyethylene glycol and N, N-dimethylformamide.
Preferably, the surfactant is selected from one or more of dodecyl dimethyl betaine, cocamidopropyl betaine, calcium dodecyl benzene sulfonate, sodium dodecyl sulfate, tween 80, hydroxyethyl cellulose and styryl phenol polyoxyethylene ether.
The abamectin preparation for aquaculture can kill parasites efficiently and prevent secondary infection of wounds caused by the parasites effectively; can also be uniformly dispersed in the culture water body, avoids overhigh local concentration and greatly reduces the toxic and side effects of effective components and solvents; greatly reduces the use amount of organic solvent, cost and pollution; the preparation method is simple and easy to operate, and the production equipment only needs a common temperature control reaction kettle.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
FIG. 1 is a flow chart of a preparation method of the abamectin preparation for aquaculture.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The invention provides an abamectin preparation for aquaculture, which comprises the following components in parts by weight: 1-5 parts of abamectin, 1-10 parts of tannic acid, 1-30 parts of an organic solvent, 1-30 parts of a surfactant and 25-96 parts of water.
The abamectin is an antibiotic insecticide, acaricide, nematicide, belongs to an insect nerve poison, has the action mechanism of interfering the physiological activity of parasite nerves, stimulating to release gamma-aminobutyric acid, acting on a nerve-muscle joint, increasing the release of chloride ions, inhibiting the information transfer of the nerve joint, leading parasites such as pests, mites and the like to be paralyzed and poisoned to die, and can be used for killing parasitic diseases such as sinnaea, lernaea, trichodina, dactylogyrus, nematode larvae and the like parasitized on fish bodies or branchia. Tannic acid: the tannic acid is yellow or light brown light amorphous powder or flake, has no odor, little special odor, and extremely astringent taste, and has effects of diminishing inflammation, relieving swelling, and promoting wound healing. The abamectin is supplemented with tannic acid, so that the parasite can be efficiently killed, and secondary infection of a wound caused by killing the parasite can be effectively prevented.
The organic solvent is selected from one or more of ethanol, methanol, xylene, toluene, polyethylene glycol and N, N-dimethylformamide. The organic solvent can dissolve the abamectin and dissolve the abamectin with water, and the microemulsion is convenient to prepare.
The surfactant is selected from one or more of dodecyl dimethyl betaine, cocamidopropyl betaine, calcium dodecylbenzene sulfonate, sodium dodecyl sulfate, Tween 80, hydroxyethyl cellulose, and styrylphenol polyoxyethylene ether. Preferably, the surfactant is an anionic surfactant and a nonionic surfactant. The surfactant emulsifies, disperses and increases the permeability of the abamectin and the organic solvent to form a micro-emulsion abamectin preparation, so that the abamectin preparation is uniformly dispersed in the aquaculture water body, the overhigh local concentration is avoided, the toxic and side effects of the effective components and the organic solvent are greatly reduced, the usage amount of the organic solvent is greatly reduced, and the cost and the pollution are reduced.
In one embodiment, the abamectin preparation for aquaculture comprises 1 part of abamectin, 5 parts of tannic acid, 10 parts of N, N-dimethylformamide, 10 parts of ethanol, 10 parts of calcium dodecylbenzene sulfonate, 10 parts of styrylphenol polyoxyethylene ether and 54 parts of water in parts by weight.
The invention also provides a preparation method of the abamectin preparation for aquaculture, which comprises the following steps:
step S1: adding 1-30 parts of organic solvent into a reaction kettle according to parts by weight;
step S2: then adding 1-5 parts of abamectin, 1-10 parts of tannic acid and 1-30 parts of surfactant
Stirring the organic solvent to obtain a mixed solution;
step S3: and adding 25-96 parts by weight of water into the mixed solution, and uniformly stirring to obtain the abamectin preparation for aquaculture.
Wherein, in the step S2: stirring for 10-30 minutes by using a stirrer with the rotating speed of 100-200 revolutions per minute, and in the step S3: stirring the mixture for 20 to 40 minutes by using a stirrer with the rotating speed of 100 to 200 revolutions per minute, wherein in the step S2 and the step S3, the reaction temperature of the reaction kettle is 40 to 45 ℃. The reaction kettle is an enamel reaction kettle to avoid organic solvent corrosion in the preparation process.
The abamectin preparation for aquaculture is micro-emulsion, has high flash point, is non-combustible and non-explosive, and is safe to produce, store, transport and use; benzene organic solvents are not used or are used less, so that the environmental pollution is small, the toxicity to producers and users is greatly reduced, and the improvement of the ecological environment quality and the energy conservation are facilitated; the pesticide composition has the advantages of ultrafine particles, good permeability and high absorption rate, and compared with missible oil with the same content of effective components, the pesticide composition has obviously improved control effect; water is used as a substrate, so that the resource is rich and cheap, the product cost is low, and the package is easy; the odor of the spray is light.
Therefore, the abamectin preparation for aquaculture can kill parasites efficiently and can also effectively prevent wounds caused by the parasites from generating secondary infection; can also be uniformly dispersed in the culture water body, avoids overhigh local concentration and greatly reduces the toxic and side effects of effective components and solvents; greatly reduces the use amount of organic solvent, cost and pollution; the preparation method is simple and easy to operate, and the production equipment only needs a common temperature control reaction kettle.
Example one
An abamectin preparation for aquaculture comprises the following components in parts by weight: 5 parts of abamectin, 10 parts of tannic acid, 10 parts of ethanol, 10 parts of methanol, 10 parts of N, N-dimethylformamide, 20 parts of sodium dodecyl sulfate, 10 parts of dodecyl dimethyl betaine and 25 parts of water.
The preparation method of the abamectin preparation for aquaculture comprises the following steps: adding organic solvents which comprise 10 parts of ethanol, 10 parts of methanol and 10 parts of N, N-dimethylformamide in parts by weight into a reaction kettle; adding 5 parts of abamectin, 10 parts of tannic acid, 20 parts of sodium dodecyl sulfate and 10 parts of dodecyl dimethyl betaine into the organic solvent, and stirring uniformly at the temperature of 45 ℃ for 30 minutes by using a stirrer with the rotating speed of 200 revolutions per minute to obtain a mixed solution; adding 25 parts by weight of water into the mixed solution, stirring for 40 minutes at 45 ℃ by using a stirrer with the rotating speed of 200 revolutions per minute, and uniformly stirring to obtain the abamectin preparation for aquaculture.
Example two
An abamectin preparation for aquaculture comprises the following components in parts by weight: 1 part of abamectin, 1 part of tannic acid, 1 part of polyethylene glycol, 1 part of hydroxyethyl cellulose and 96 parts of water.
The preparation method of the abamectin preparation for aquaculture comprises the following steps: adding 1 part by weight of organic solvent of polyethylene glycol into a reaction kettle; then adding 1 part of abamectin, 1 part of tannic acid and 1 part of hydroxyethyl cellulose into the organic solvent, and stirring uniformly at 40 ℃ for 10 minutes by using a stirrer with the rotating speed of 100 revolutions per minute to obtain a mixed solution; adding 96 parts by weight of water into the mixed solution, stirring for 20 minutes by a stirrer with the rotating speed of 100 revolutions per minute at the temperature of 40 ℃, and uniformly stirring to obtain the abamectin preparation for aquaculture.
EXAMPLE III
An abamectin preparation for aquaculture comprises the following components in parts by weight: 3 parts of abamectin, 8 parts of tannic acid, 10 parts of ethanol, 20 parts of cocamidopropyl betaine and 59 parts of water.
The preparation method of the abamectin preparation for aquaculture comprises the following steps: adding 10 parts by weight of organic solvent into a reaction kettle; adding 3 parts of abamectin, 8 parts of tannic acid and 20 parts of cocamidopropyl betaine into the organic solvent, and stirring the mixture uniformly for 20 minutes by using a stirrer with the rotation speed of 150 revolutions per minute at the temperature of 43 ℃ to obtain a mixed solution; adding 59 parts by weight of water into the mixed solution, stirring for 30 minutes at 43 ℃ by using a stirrer with the rotating speed of 150 revolutions per minute, and uniformly stirring to obtain the abamectin preparation for aquaculture.
Example four
An abamectin preparation for aquaculture comprises the following components in parts by weight: 2 parts of abamectin, 6 parts of tannic acid, 10 parts of N, N-dimethylformamide, 10 parts of methanol, 10 parts of sodium dodecyl sulfate and 62 parts of water.
The preparation method of the abamectin preparation for aquaculture comprises the following steps: adding 10 parts by weight of N, N-dimethylformamide and 10 parts by weight of methanol into a reaction kettle; then adding 2 parts of abamectin, 6 parts of tannic acid and 10 parts of sodium dodecyl sulfate into the organic solvent, and stirring the mixture uniformly for 25 minutes by using a stirrer with the rotating speed of 130 revolutions per minute at the temperature of 40 ℃ to obtain a mixed solution; adding 62 parts by weight of water into the mixed solution, stirring for 35 minutes at 40 ℃ by using a stirrer with the rotating speed of 130 revolutions per minute, and uniformly stirring to obtain the abamectin preparation for aquaculture.
EXAMPLE five
An abamectin preparation for aquaculture comprises the following components in parts by weight: 1 part of abamectin, 5 parts of tannic acid, 10 parts of N, N-dimethylformamide, 10 parts of ethanol, 10 parts of calcium dodecylbenzene sulfonate, 10 parts of styrylphenol polyoxyethylene ether and 54 parts of water.
The preparation method of the abamectin preparation for aquaculture comprises the following steps: adding 10 parts by weight of N, N-dimethylformamide and 10 parts by weight of ethanol into a reaction kettle; adding 1 part of abamectin, 5 parts of tannic acid, 10 parts of calcium dodecyl benzene sulfonate and 10 parts of styrylphenol polyoxyethylene ether into the organic solvent, and stirring uniformly for 30 minutes by using a stirrer with the rotating speed of 160 revolutions per minute at the temperature of 40 ℃ to obtain a mixed solution; adding 54 parts by weight of water into the mixed solution, stirring for 30 minutes by using a stirrer with the rotating speed of 160 revolutions per minute at the temperature of 40 ℃, and uniformly stirring to obtain the abamectin preparation for aquaculture.
The test effect of the compound acidifier for aquaculture is verified by the following specific tests:
1. accelerated test and long-term test
The test samples are accelerated for A, B, C three groups, and are placed for six months under the conditions that the temperature is 40 +/-2 ℃ and the relative humidity is 75 +/-5%, and the appearance, the content, the emulsification stability and the pH value of the abamectin preparation for aquaculture are detected, and the results are shown in the following table 1.
The long-term test samples comprise A, B, C groups, and are respectively sampled at the end of 3 months, 6 months, 9 months and 12 months under the conditions that the temperature is 25 +/-2 ℃ and the relative humidity is 60 +/-5%, and the appearance, the content determination, the emulsion stability and the pH value of the abamectin preparation for aquaculture are detected, and the results are shown in table 2.
Wherein A, B, C three groups of test samples were obtained by the formulation and preparation method of the fifth embodiment of the present invention, and A, B, C three groups of tests were different: the materials are prepared by adopting the formula and the method of the fifth embodiment in three batches, and are used for carrying out parallel tests to verify the stability of the production process.
TABLE 1 accelerated test results
Wherein, the content refers to the relative content of the avermectin, namely the content positioning 1 of the initial sample.
TABLE 2 Long-term test results
As can be seen from the test results in tables 1 and 2, the abamectin preparation for aquaculture of the invention is qualified in the stability important indexes such as appearance, content, emulsion stability, pH value and the like, and can reach the drug stability level.
2. Test effect verification
In a certain fishing ground in Ningxiang city of Changxi city in Hunan province, 2 adjacent ponds have similar initial conditions, the size of the pond is about 2 mu, the water depth is about 2 m, and the cultured fishes are all infected by sinergasia and other parasites.
Experimental design, four groups of experiments are designed:
control group a 0: 90 percent of trichlorfon, and then the trichlorfon is diluted to 0.5ppm concentration by water for use;
test group a 1: the abamectin preparation for aquaculture in the fifth embodiment of the invention is diluted with water to be prepared into the abamectin preparation with the concentration of 0.15 ppm;
test group a 2: the abamectin preparation for aquaculture in the fifth embodiment of the invention is produced in the same batch as the experimental group A1, and is diluted with water to be prepared into the abamectin preparation with the concentration of 0.1 ppm;
test group a 3: the abamectin preparation for aquaculture in the fifth embodiment of the invention is produced in the same batch as the test groups A1 and A2, and is diluted with water to be prepared into the abamectin preparation with the concentration of 0.05 ppm;
the test group and the control group are basically identical in other conditions (including the seedling placing quantity and proportion, the bait application time and dosage, the oxygen charging time, the disinfection and the like). The results of measuring sinergasilliasis and other parasites in water quality at the same water intake point every 24 hours are shown in Table 3. Experiment time: 10 days 4 months in 2017-11 days 4 months in 2017.
TABLE 3 insecticidal Effect comparison
As can be seen from Table 2, the abamectin preparation for aquaculture has the effects of high killing rate, small use concentration, long lasting period and the like on common parasites in aquaculture compared with the traditional medicine trichlorfon.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes performed by the present specification and drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (8)
1. An abamectin preparation for aquaculture is characterized by comprising the following components in parts by weight: 1-5 parts of abamectin, 1-10 parts of tannic acid, 1-30 parts of an organic solvent, 1-30 parts of a surfactant and 25-96 parts of water, wherein the surfactant is selected from one or more of dodecyl dimethyl betaine, cocamidopropyl betaine, calcium dodecyl benzene sulfonate, sodium dodecyl sulfate, hydroxyethyl cellulose and styrylphenol polyoxyethylene ether.
2. The avermectin formulation for aquaculture according to claim 1, wherein the organic solvent is selected from one or more of ethanol, methanol, polyethylene glycol, N-dimethylformamide.
3. The abamectin preparation for aquaculture according to claim 1, which comprises 1 part of abamectin, 5 parts of tannic acid, 10 parts of N, N-dimethylformamide, 10 parts of ethanol, 10 parts of calcium dodecylbenzene sulfonate, 10 parts of styrylphenol polyoxyethylene ether and 54 parts of water in parts by weight.
4. A process for the preparation of an avermectin formulation for aquaculture as claimed in claim 1 comprising the steps of: step S1: adding 1-30 parts of organic solvent into a reaction kettle according to parts by weight;
step S2: adding 1-5 parts of abamectin, 1-10 parts of tannic acid and 1-30 parts of surfactant into the organic solvent, and stirring to obtain a mixed solution;
step S3: and adding 25-96 parts by weight of water into the mixed solution, and uniformly stirring to obtain the abamectin preparation for aquaculture.
5. The method for preparing avermectin preparation for aquaculture as claimed in claim 4, wherein in step S2: stirring the mixture for 10 to 30 minutes by using a stirrer with the rotating speed of 100 to 200 revolutions per minute.
6. The method for preparing avermectin preparation for aquaculture as claimed in claim 4, wherein in step S3: stirring the mixture for 20 to 40 minutes by using a stirrer with the rotating speed of 100 to 200 revolutions per minute.
7. The method for preparing avermectin preparation for aquaculture as claimed in claim 4, wherein the reaction temperature of the reaction kettle is 40-45 ℃ in step S2 and step S3.
8. The method for preparing avermectin preparation for aquaculture as claimed in claim 4, wherein the organic solvent is selected from one or more of ethanol, methanol, polyethylene glycol and N, N-dimethylformamide.
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| CN105815570A (en) * | 2016-03-25 | 2016-08-03 | 广州英赛特生物技术有限公司 | Application of albumin tannate in preparation of feed additive for animals |
| CN107320481A (en) * | 2017-07-12 | 2017-11-07 | 浙江省淡水水产研究所 | Application of the tannic acid in killing and preventing aquatic livestock vermin |
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