CN108042558A - Avermectin preparation used for aquiculture and preparation method thereof - Google Patents
Avermectin preparation used for aquiculture and preparation method thereof Download PDFInfo
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- CN108042558A CN108042558A CN201711319465.3A CN201711319465A CN108042558A CN 108042558 A CN108042558 A CN 108042558A CN 201711319465 A CN201711319465 A CN 201711319465A CN 108042558 A CN108042558 A CN 108042558A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Abstract
The invention discloses a kind of avermectin preparations used for aquiculture, count in parts by weight, including following component：1~5 part of avermectin, 1~10 part of tannic acid, 1~30 part of organic solvent, 1~30 part of surfactant, 25~96 parts of water.The avermectin preparation used for aquiculture of the present invention, you can efficiently kill parasite, and scabies secondary infection occurs for wound caused by can effectively preventing above-mentioned parasite；Breeding water body can be also dispersed in, avoids local concentration excessively high, greatly reduces active ingredient and the toxic side effect of solvent；The usage amount of organic solvent is substantially reduced, reduces cost and pollution；Preparation method is simple to operation, and production equipment only needs common temperature control reaction kettle.
Description
Technical field
The invention belongs to technical field of aquaculture, and in particular to a kind of avermectin preparation used for aquiculture and its preparation
Method.
Background technology
Currently, the generation of the disease triggered due to the parasite of aquiculture animal and bacterium, virus, to culture fishery
Cause great economic loss.The common pathogen of the parasites formula aquaculture such as Chinese Sao, anchor head Sao, small melonworm, Dactylogyrus,
It is very harmful.In fishery insecticide, the drugs such as DDVP, malachite green due to there are security it is poor, pollute environment and endanger people
Class health and be eliminated, though there is vegetalitas fish insect killing agent in the prevention of aquatic animal disease, there are usage amount is big, take effect
Slowly, killing effect is not thorough, it is of high cost the shortcomings of.Avermectin is the macrolides anti parasitic generated by Avid kyowamycin
Drug, have to nematode, China Sao, anchor head Sao it is extremely strong kill effect, be widely used in aquatic livestock body, epizoite
The prevention of worm.But existing abamectin insecticide, mostly with the avermectin of single composition or avermectin and other desinsections
The compound insecticide of agent composition, this insecticides have the disadvantages that：All it is the missible oil class of pesticide type using benzene class as solvent
Insecticide, effect on environment is very big, and crop residual and toxic side effect are big, and long-time service makes parasite easily develop immunity to drugs, shadow
Ring the sound development of China's fishery industry.
The content of the invention
The present invention provides a kind of avermectin preparation used for aquiculture and preparation method thereof, can efficiently kill parasitism
Worm, but scabies secondary infection occurs for wound caused by can effectively preventing above-mentioned parasite；Breeding water body can be also dispersed in, avoids office
Portion's excessive concentration greatly reduces active ingredient and the toxic side effect of solvent.
In order to solve the above technical problems, one aspect of the present invention is to provide a kind of Avermectin used for aquiculture
Plain preparation, is counted in parts by weight, including following component：1~5 part of avermectin, 1~10 part of tannic acid, 1~30 part of organic solvent,
1~30 part of surfactant, 25~96 parts of water.
Preferably, one kind in ethyl alcohol, methanol, polyethylene glycol, n,N-Dimethylformamide of the organic solvent or
It is a variety of.
Preferably, the surfactant is selected from dodecyldimethylammonium hydroxide inner salt, Cocoamidopropyl betaine, 12
One in alkyl benzene calcium sulfonate, lauryl sodium sulfate, Tween 80, hydroxyethyl cellulose, styrylphenol polyoxyethylene ether
Kind is a variety of.
Preferably, count in parts by weight, the avermectin preparation used for aquiculture includes 1 part of avermectin, tannic acid 5
Part, 10 parts of N,N-dimethylformamide, 10 parts of ethyl alcohol, 10 parts of calcium dodecyl benzene sulfonate, styrylphenol polyoxyethylene ether
10 parts and 54 parts of water.
The present invention also provides a kind of preparation methods of avermectin preparation used for aquiculture, comprise the following steps：
Step S1：In parts by weight in 1~30 part of addition reaction kettle of organic solvent；
Step S2：It is above-mentioned organic molten by 1~30 part of 1~5 part of avermectin, 1~10 part of tannic acid, surfactant addition again
It is stirred to obtain mixed liquor in agent；
Step S3：The water that parts by weight are 25~96 parts is added in into above-mentioned mixed solution and is uniformly mixing to obtain aquaculture
With avermectin preparation.
Preferably, in the step S2：It is stirred 10~30 minutes with the mixer that rotating speed is 100~200 turns per minute.
Preferably, in the step S3：It is stirred 20~40 minutes with the mixer that rotating speed is 100~200 turns per minute.
Preferably, in the step S2 and step S3, the reaction temperature of the reaction kettle is at 40 DEG C~45 DEG C.
Preferably, one kind in ethyl alcohol, methanol, polyethylene glycol, n,N-Dimethylformamide of the organic solvent or
It is a variety of.
Preferably, the surfactant is selected from dodecyldimethylammonium hydroxide inner salt, Cocoamidopropyl betaine, 12
One in alkyl benzene calcium sulfonate, lauryl sodium sulfate, Tween 80, hydroxyethyl cellulose, styrylphenol polyoxyethylene ether
Kind is a variety of.
The avermectin preparation used for aquiculture of the present invention, you can efficiently kill parasite, and can effectively prevent above-mentioned post
Scabies secondary infection occurs for wound caused by infested；Breeding water body can be also dispersed in, avoids local concentration excessively high, greatly reduces
The toxic side effect of active ingredient and solvent；The usage amount of organic solvent is substantially reduced, reduces cost and pollution；Preparation method is simple
Easy to operate, production equipment only needs common temperature control reaction kettle.
Description of the drawings
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described, it should be apparent that, the accompanying drawings in the following description is only some embodiments of the present invention, for
For those of ordinary skill in the art, without creative efforts, other are can also be obtained according to these attached drawings
Attached drawing, wherein：
Fig. 1 is the preparation method flow chart of the avermectin preparation used for aquiculture of the present invention.
Specific embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work
Embodiment belongs to the scope of protection of the invention.
The present invention provides a kind of avermectin preparations used for aquiculture, count in parts by weight, including following component：AVM hereinafter
1~5 part of rhzomorph, 1~10 part of tannic acid, 1~30 part of organic solvent, 1~30 part of surfactant, 25~96 parts of water.
Avermectin is a kind of antibiotics desinsection, mite killing, nematicide, belongs to insect never poison, the mechanism of action is dry
Parasite nervous physiology activity is disturbed, release γ-aminobutyric acid is stimulated, acts on nerve and neuromuscular junction, increase releasing for chlorion
It puts, the information for inhibiting neural connector is transferred, and the parasites such as pest and evil mite is caused to occur benumbing and being poisoned to death, available for killing
The parasitic diseases such as parasitic Chinese Sao, anchor head Sao, Trichodina, Dactylogyrus, nematode young in fish body or the gill.Tannic acid：Tannic acid
Be yellow or light brown lightweight without crystalline substance powder or scale, odorless, micro- to have special odor, taste is extremely puckery, has anti-inflammatory detumescence, promotes
The effect of wound healing.Avermectin is aided with tannic acid, you can efficiently kills parasite, and can effectively prevent that killing parasite causes
Wound occur scabies secondary infection.
One kind in ethyl alcohol, methanol, dimethylbenzene, toluene, polyethylene glycol, N,N-dimethylformamide of organic solvent or
It is a variety of.Organic solvent can dissolve avermectin, and can be miscible with water, facilitates and prepares microemulsion dosage.
Surfactant is selected from dodecyldimethylammonium hydroxide inner salt, Cocoamidopropyl betaine, dodecyl benzene sulfonic acid
One or more in calcium, lauryl sodium sulfate, Tween 80, hydroxyethyl cellulose, styrylphenol polyoxyethylene ether.It is excellent
Choosing, surfactant compounds nonionic surface active agent for anionic surfactant.Surfactant is to Avermectin
Element and organic solvent are emulsified, disperseed and anatonosis is to form the avermectin preparation of micro-emulsion type, make avermectin preparation uniform
Breeding water body is scattered in, avoids local concentration excessively high, greatly reduces active ingredient and the toxic side effect of organic solvent, and significantly
The usage amount of organic solvent is reduced, reduces cost and pollution.
In one of the embodiments, avermectin preparation used for aquiculture of the invention is counted in parts by weight, including Ah
Tie up 1 part of rhzomorph, 5 parts of tannic acid, 10 parts of N,N-dimethylformamide, 10 parts of ethyl alcohol, 10 parts of calcium dodecyl benzene sulfonate, styryl
54 parts of 10 parts of phenol polyoxyethylene ether and water.
The present invention also provides a kind of preparation methods of above-mentioned avermectin preparation used for aquiculture, comprise the following steps：
Step S1：In parts by weight in 1~30 part of addition reaction kettle of organic solvent；
Step S2：Again by 1~30 part of 1~5 part of avermectin, 1~10 part of tannic acid, surfactant addition
It is stirred to obtain mixed liquor in above-mentioned organic solvent；
Step S3：The water that parts by weight are 25~96 parts is added in into above-mentioned mixed solution and is uniformly mixing to obtain aquaculture
With avermectin preparation.
Wherein, in the step S2：It is stirred 10~30 minutes with the mixer that rotating speed is 100~200 turns per minute, it is described
In step S3：It is stirred 20~40 minutes with the mixer that rotating speed is 100~200 turns per minute, in the step S2 and step S3,
The reaction temperature of the reaction kettle is at 40 DEG C~45 DEG C.Reaction kettle is enamel reaction still, to avoid in preparation process, You Jirong
Agent corrosion reacting kettle.
The avermectin preparation used for aquiculture of the present invention is micro-emulsion type, has flash-point high, non-ignitable not quick-fried, produces, storing
With it is safe to use；Benzene class organic solvent is used no or little, environmental pollution is small, and the murder by poisoning of the producer and user are considerably reduced,
Be conducive to improvement and the energy conservation of eco-environmental quality；Particle is ultra tiny, has excellent permeability, absorptivity is high, has with identical
The missible oil of effective component content is compared, and preventive effect significantly improves；Water is matrix, and resourceful inexpensive, product cost is low, and packaging is easy；
It is lighter to spray stink.
Therefore, avermectin preparation used for aquiculture of the invention, you can efficiently kill parasite, and can effectively prevent
Scabies secondary infection occurs for wound caused by stating parasite；Breeding water body can be also dispersed in, avoids local concentration excessively high, drops significantly
The low toxic side effect of active ingredient and solvent；The usage amount of organic solvent is substantially reduced, reduces cost and pollution；Preparation method
Simple to operation, production equipment only needs common temperature control reaction kettle.
Embodiment one
A kind of avermectin preparation used for aquiculture, is counted, in parts by weight including following component：5 parts of avermectin, tannic acid
10 parts, 10 parts of ethyl alcohol, 10 parts of methanol, 10 parts of n,N-Dimethylformamide, 20 parts of lauryl sodium sulfate, dodecyl dimethyl
10 parts of glycine betaine, 25 parts of water.
The preparation method of the avermectin preparation used for aquiculture of the present embodiment is：It is in parts by weight 10 parts of ethyl alcohol, first
10 parts of alcohol, the organic solvent of 10 parts of N,N-dimethylformamide are added in reaction kettle；Again by 5 parts of avermectin, 10 parts of tannic acid, ten
20 parts of sodium dialkyl sulfate, 10 parts of dodecyldimethylammonium hydroxide inner salt are added in above-mentioned organic solvents, at a temperature of 45 DEG C, with turning
Speed is uniformly mixing to obtain mixed liquor in 30 minutes for 200 turns per minute of mixer stirring；Weight is added in into above-mentioned mixed solution
Number is 25 parts of water, at a temperature of 45 DEG C, is stirred 40 minutes, stirred evenly with the mixer that rotating speed is 200 turns per minute
To the avermectin preparation used for aquiculture of the present embodiment.
Embodiment two
A kind of avermectin preparation used for aquiculture, is counted, in parts by weight including following component：1 part of avermectin, tannic acid
1 part, 1 part of polyethylene glycol, 1 part of hydroxyethyl cellulose, 96 parts of water.
The preparation method of the avermectin preparation used for aquiculture of the present embodiment is：It is 1 part of polyethylene glycol in parts by weight
Organic solvent add in reaction kettle in；It is above-mentioned organic molten by 1 part of 1 part of avermectin, 1 part of tannic acid, hydroxyethyl cellulose addition again
In agent, at a temperature of 40 DEG C, stirred 10 minutes with the mixer that rotating speed is 100 turns per minute and be uniformly mixing to obtain mixed liquor；To
The water that parts by weight are 96 parts is added in above-mentioned mixed solution, at a temperature of 40 DEG C, with the mixer that rotating speed is 100 turns per minute
Stirring 20 minutes is uniformly mixing to obtain the avermectin preparation used for aquiculture of the present embodiment.
Embodiment three
A kind of avermectin preparation used for aquiculture, is counted, in parts by weight including following component：3 parts of avermectin, tannic acid
8 parts, 10 parts of ethyl alcohol, 20 parts of Cocoamidopropyl betaine, 59 parts of water.
The preparation method of the avermectin preparation used for aquiculture of the present embodiment is：Having for 10 parts of ethyl alcohol in parts by weight
Solvent is added in reaction kettle；It is above-mentioned organic by 20 parts of 3 parts of avermectin, 8 parts of tannic acid, Cocoamidopropyl betaine additions again
In solvent, at a temperature of 43 DEG C, stirred 20 minutes with the mixer that rotating speed is 150 turns per minute and be uniformly mixing to obtain mixed liquor；
The water that parts by weight are 59 parts is added in into above-mentioned mixed solution, at a temperature of 43 DEG C, with the stirring that rotating speed is 150 turns per minute
Machine stirs 30 minutes, is uniformly mixing to obtain the avermectin preparation used for aquiculture of the present embodiment.
Example IV
A kind of avermectin preparation used for aquiculture, is counted, in parts by weight including following component：2 parts of avermectin, tannic acid
6 parts, 10 parts of n,N-Dimethylformamide, 10 parts of methanol, 10 parts of lauryl sodium sulfate, 62 parts of water.
The preparation method of the avermectin preparation used for aquiculture of the present embodiment is：It is in parts by weight N, N- dimethyl methyls
10 parts of amide, the organic solvent of 10 parts of methanol are added in reaction kettle；Again by 2 parts of avermectin, 6 parts of tannic acid, dodecyl sulphate
10 parts of sodium is added in above-mentioned organic solvent, at a temperature of 40 DEG C, is stirred 25 minutes and stirred with the mixer that rotating speed is 130 turns per minute
It mixes and uniformly obtains mixed liquor；The water that parts by weight are 62 parts is added in into above-mentioned mixed solution, at a temperature of 40 DEG C, is with rotating speed
130 turns per minute of mixer stirs 35 minutes, is uniformly mixing to obtain the avermectin preparation used for aquiculture of the present embodiment.
Embodiment five
A kind of avermectin preparation used for aquiculture, is counted, in parts by weight including following component：1 part of avermectin, tannic acid
5 parts, 10 parts of N,N-dimethylformamide, 10 parts of ethyl alcohol, 10 parts of calcium dodecyl benzene sulfonate, styrylphenol polyoxyethylene ether
10 parts and 54 parts of water.
The preparation method of the avermectin preparation used for aquiculture of the present embodiment is：It is in parts by weight N, N- dimethyl methyls
10 parts of amide, the organic solvent of 10 parts of ethyl alcohol are added in reaction kettle；Again by 1 part of avermectin, 5 parts of tannic acid, detergent alkylate sulphur
Sour 10 parts of calcium, 10 parts of styrylphenol polyoxyethylene ether are added in above-mentioned organic solvent, are every with rotating speed at a temperature of 40 DEG C
The mixer of 160 turns of minute stirs 30 minutes and is uniformly mixing to obtain mixed liquor；Parts by weight are added in into above-mentioned mixed solution is
54 parts of water at a temperature of 40 DEG C, is stirred 30 minutes with the mixer that rotating speed is 160 turns per minute, is uniformly mixing to obtain this reality
Apply the avermectin preparation used for aquiculture of example.
Test effect of the compound acidulant of the present invention in aquaculture is tested below by way of specific experiment
Card：
1st, accelerated test and long term test
Tri- groups of accelerated test sample common A, B, C place six under conditions of 40 ± 2 DEG C of temperature, relative humidity 75 ± 5%
Appearance character, assay, emulsion stability and the pH value of avermectin preparation used for aquiculture are detected by the moon, as a result such as the following table 1
It is shown.
Tri- groups of long term test sample common A, B, C, under conditions of 25 ± 2 DEG C of temperature, relative humidity 60 ± 5%, in 3,6,
9th, 12 the end of month are separately sampled, detect the appearance character of avermectin preparation used for aquiculture, assay, emulsion stability and
PH value, the results are shown in Table 2.
Wherein tri- groups of test specimens of A, B, C are obtained using the formula and preparation method of the embodiment of the present invention five, and
A, the difference of tri- groups of experiments of B, C is：It is manufactured in three batches using the formula and method of embodiment five, to carry out parallel test,
Verify the stability of production technology.
1 Acceleration study result of table
Wherein, content refers to the content positioning 1 of the relative amount of avermectin, i.e. initial sample.
2 long-term test results of table
The avermectin formulation aesthetics character used for aquiculture of the present invention is can be seen that from Tables 1 and 2 result of the test, is contained
Amount, emulsion stability in pH value equistability important indicator are qualification, can reach stability of drug products rank.
2nd, test effect is verified
In Changsha, Hunan city of Ningxiang fishing ground, 2 ponds closing on, the primary condition in pond is similar, and size is 2 mu
Left and right, 2 meters or so of the depth of water have the parasitic infections such as Chinese Sao through examining cultured fishes.
Experimental design designs four groups of experiments：
Control group A 0：Then 90% metrifonate is diluted with water to the use of 0.5ppm concentration；
Test group A1：The avermectin preparation used for aquiculture of the embodiment of the present invention five, is configured to after being then diluted with water
Concentration is 0.15ppm；
Test group A2：The avermectin preparation used for aquiculture of the embodiment of the present invention five is same batch with experimental group A1
Production is configured to concentration as 0.1ppm after being diluted with water；
Test group A3：The avermectin preparation used for aquiculture of the embodiment of the present invention five is same with test group A1 and A2
Batch produces, and concentration is configured to after being diluted with water as 0.05ppm；
Test group and the other conditions of control group it is essentially identical (including put seedling quantity and ratio, bait administration time and dosage,
Rush oxygen time, disinfection etc.).The parasites such as water quality China Sao are carried out when 24 is small to the same dry point of water quality to measure, as a result
As shown in table 3.Experimental period：On April 11, -2017 years on the 10th April in 2017.
3 insecticidal effect of table compares
From table 2 it can be seen that the avermectin preparation used for aquiculture of the present invention is to common parasitic worm phase in aquaculture
There is killing rate high than traditional drug metrifonate, concentration is small, lasting period length and other effects.
The foregoing is merely embodiments of the present invention, are not intended to limit the scope of the invention, every to utilize this
It is relevant to be directly or indirectly used in other for the equivalent structure or equivalent flow shift that description of the invention and accompanying drawing content are made
Technical field is included within the scope of the present invention.
Claims (10)
1. a kind of avermectin preparation used for aquiculture, which is characterized in that count in parts by weight, including following component：Avermectin
1~5 part of element, 1~10 part of tannic acid, 1~30 part of organic solvent, 1~30 part of surfactant, 25~96 parts of water.
2. avermectin preparation used for aquiculture according to claim 1, which is characterized in that the organic solvent is selected from second
One or more in alcohol, methanol, polyethylene glycol, N,N-dimethylformamide.
3. avermectin preparation used for aquiculture according to claim 1, which is characterized in that the surfactant is selected from
Dodecyldimethylammonium hydroxide inner salt, Cocoamidopropyl betaine, calcium dodecyl benzene sulfonate, lauryl sodium sulfate, tween
80th, the one or more in hydroxyethyl cellulose, styrylphenol polyoxyethylene ether.
4. avermectin preparation used for aquiculture according to claim 1, which is characterized in that it counts in parts by weight, it is described
Avermectin preparation used for aquiculture include 1 part of avermectin, 5 parts of tannic acid, 10 parts of N,N-dimethylformamide, 10 parts of ethyl alcohol,
54 parts of 10 parts of calcium dodecyl benzene sulfonate, 10 parts of styrylphenol polyoxyethylene ether and water.
5. a kind of preparation method of avermectin preparation used for aquiculture, which is characterized in that comprise the following steps：Step S1：It presses
Parts by weight are in 1~30 part of addition reaction kettle of organic solvent；
Step S2：It is added in again by 1~5 part of avermectin, 1~10 part of tannic acid, 1~30 part of surfactant in above-mentioned organic solvent
It is stirred to obtain mixed liquor；
Step S3：Added in into above-mentioned mixed solution parts by weight be 25~96 parts of water be uniformly mixing to obtain Ah. used for aquiculture
Tie up rhzomorph preparation.
6. the preparation method of avermectin preparation used for aquiculture according to claim 5, which is characterized in that the step
In S2：It is stirred 10~30 minutes with the mixer that rotating speed is 100~200 turns per minute.
7. the preparation method of avermectin preparation used for aquiculture according to claim 5, which is characterized in that the step
In S3：It is stirred 20~40 minutes with the mixer that rotating speed is 100~200 turns per minute.
8. the preparation method of avermectin preparation used for aquiculture according to claim 5, which is characterized in that the step
In S2 and step S3, the reaction temperature of the reaction kettle is at 40 DEG C~45 DEG C.
9. the preparation method of avermectin preparation used for aquiculture according to claim 5, which is characterized in that described organic
One or more of the solvent in ethyl alcohol, methanol, polyethylene glycol, N,N-dimethylformamide.
10. the preparation method of avermectin preparation used for aquiculture according to claim 5, which is characterized in that the table
Face activating agent is selected from dodecyldimethylammonium hydroxide inner salt, Cocoamidopropyl betaine, calcium dodecyl benzene sulfonate, dodecyl
One or more in sodium sulphate, Tween 80, hydroxyethyl cellulose, styrylphenol polyoxyethylene ether.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112931528A (en) * | 2021-01-28 | 2021-06-11 | 清远海贝生物技术有限公司 | Safe disinfectant special for raw fish overwintering culture water body and application thereof |
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| CN101301299A (en) * | 2007-05-11 | 2008-11-12 | 广州洁成生物科技有限公司 | Medicament composition and use thereof in preparing antimicrobial medicament |
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| CN112931528A (en) * | 2021-01-28 | 2021-06-11 | 清远海贝生物技术有限公司 | Safe disinfectant special for raw fish overwintering culture water body and application thereof |
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