CN101301299A - Medicament composition and use thereof in preparing antimicrobial medicament - Google Patents
Medicament composition and use thereof in preparing antimicrobial medicament Download PDFInfo
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- CN101301299A CN101301299A CNA2007100279999A CN200710027999A CN101301299A CN 101301299 A CN101301299 A CN 101301299A CN A2007100279999 A CNA2007100279999 A CN A2007100279999A CN 200710027999 A CN200710027999 A CN 200710027999A CN 101301299 A CN101301299 A CN 101301299A
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Abstract
The invention relates to an application of glycyrrhizic acid or a compound of a salt thereof and tannic acid and triclosan in the preparation of anti skin mucous membrane microorganism and acne drugs, in particular to the application in the preparation of drugs for preventing and treating bacteria, mycotic and virus infections of skin mucous membranes of human beings and animals, acne drugs, disinfectant and daily chemical products, wherein, the infections comprise verruca acuminate, verruca plana, common warts, colpitis, cervicitis, cervical erosion, herpes simplex, herpes zoster, herpes genitalis and aece. The application is to blend the glycyrrhizic acid or the compound of the salt thereof and the tannic acid and the riclosan with various auxiliary materials of skin mucous membrane dosage and prepare the mixture into different preparations.
Description
Technical field
The present invention relates to the application of compositions in anti-skin mucosa microorganism of preparation and acne medicine of glycyrrhizic acid or its salt, tannic acid and triclosan.The compositions that relates to glycyrrhizic acid or its salt, tannic acid and triclosan specifically is used to prepare the application of treatment humans and animals skin mucosa antibacterial, fungus, viral infection and acne medicine, disinfectant and daily chemical product.
Background technology
Glycyrrhizic acid or its salt have the nonspecific immunity regulating action, it mainly strengthens cellular immunization, can strengthen phagocytic function, optionally strengthen the multiplication capacity and the activity of helper T cell, have antimicrobial, protect the liver, various biological effect such as detoxifcation, antiinflammatory, antiallergic action, antiallergic.Carry out external anti-Epstein-Barr virus experiment [Jung-Chung Lin.Mechanism of action ofglycyrrhizic acid in inhibition of Epstein-Barr virus replication invitro[J] .Antiviral Res with glycyrrhizic acid, 2003,59:41-47], find duplicating in early days of glycyrrhizic acid viral interference, but do not influence the absorption of virus, can not make the virus particle inactivation yet; Experiment in vitro also shows, glycyrrhizic acid has anti-arboviral effect [Jean MC, Natale S, Alain J, et al.Interferon, ribavirin, 6-azauridine and glycyrrhizin:antiviral compounds activeagainst pathogenic flavivi-ruses[J] .Antiviral Res, 2003,58:73-79].
Tannic acid is as astringency, and existing on the market tannic acid ointment is used for neonate and baby, and to prevent and treat buttocks red.Tannic acid has been proved to be to be had inhibitory action to acquired immune deficiency syndrome (AIDS) HIV virus (Biochem.J 1992; 288:717-9; J.Nat.Prod.1990; 53:134-40).
Triclosan is the highly effective and safe antibiosis and sterilization agent, can kill multiple gram positive bacteria, negative bacterium and funguses such as staphylococcus aureus, escherichia coli and Candida albicans, virus is also had suppress and killing action.
Skin and mucosa infection antibacterial, fungus and viral micro-organisms are commonly encountered diseases, frequently-occurring disease, and at present many antibiotic therapies of use still usually cause drug resistance, make that skin and mucosa infection is prolonged does not heal.In addition, contacting with human body surface and carry antibacterial, fungus and virus, is the important channel of infectious disease transmission, by killing the pathogenic microbes of skin mucosa, is the important method of such disease of prevention.
Acne claims acne of youth again, is a kind of pilosebaceous chronic inflammatory disease, and good sending out in face, thoracic dorsal shows as infringements such as acne, pimple, pustule, tuberosity, cyst, is more common in youth of both sexes.Majority thinks that microorganism is closely related in primary disease and androgen, sebaceous gland and the hair follicle.In addition, heredity, diet, gastrointestinal function, environmental factors, cosmetics and Nervous and Mental Factors are also relevant with the morbidity of primary disease.
Herpesvirus has I type and I I type, infects zones of different, can be divided into herpes labialis, varicella-zoster, genital herpes etc., and virus can show as proliferative and infect and latent infection.The gene expression of virus is suppressed when infection is in latency, infects and can transfer proliferative under some stimulating factor effect.Hide and recurrent infection be the outstanding feature of herpesvirus.Virus lays dormant is in trigeminal ganglion, superior cervical ganglion and vagus ganglion, impaired as the host neuraxon of latent infection, generate heat or when being subjected to wound (as intubate etc.), ultraviolet radiation etc. and stimulating, virus can be activated and along the nerve fiber axon to tip, thereby entering innerv skin and mucosa breeds again, cause pathological change once again, cause the recurrence of local herpes.
Condyloma acuminatum, verruca vulgaris, verruca plana are the skin mucosal lesionss that is caused by human papillomavirus (HPV).
The traditional Chinese medical science thinks that the etiology and pathogenesis of condyloma acuminatum is owing to the product that sexual life is unclean or mediate contact is filthy, and damp and hot excessive poison is cloudy mucocutaneous from outer intrusion, causes the strongly fragrant gesture of Liver Channel, disharmony between QI and blood, and damp and hot malicious heresy is fought to tie and is formed wart.Because noxious dampness is a YIN pathogen, its property viscous, touching difficulty is gone, and consumption is hindered healthy energy easily, and deficient vital QI leading to lingering of pathogen so that recurrence easily are difficult to radical cure.The methods such as strengthening the body resistance, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving that adopt in treatment more.Condyloma acuminatum is based on local patholoic change, so external treatment accounts for critical role in treatment.U.S. Pat 4381296 discloses tannic acid and has been used for the treatment that herpesvirus HSV infects, but does not relate to the treatment of condyloma acuminatum HPV.At present, the medicine of treatment condyloma acuminatum has podophyllotoxin d, belongs to chemotherapy, and advantage is a short treating period, but has zest, problem that toxic and side effects is big.Concrete manifestation is pain, edema, erosion etc.
At present, existing product on the market, as acyclovir, the treatment herpes labialis takes effect slowly, often needs just recovery from illness of a week, and verruca plana adopts naturopathy means such as laser, cryotherapy more, lacks effective medicine.
Simultaneously can antibacterium, fungus, viral various skin mucosa infected by microbes, the double preparation of controlling acne is not being seen on the market with on the document as yet.The usually not clear cause of disease of skin mucosal lesions or mixed infection, acne is usually with skin infection or allergy, it is the cureless reason of many skin infections or acne, lack very much wide spectrum, efficient, low toxicity clinically, to the effective pharmaceutical preparation of drug-resistant microorganism, developing this class preparation is the anti-infectives research direction.
Summary of the invention
The present invention is that the compositions of glycyrrhizic acid or its salt, tannic acid and triclosan is as active component.
Glycyrrhizic acid extracts from Radix Glycyrrhizae, uses glycyrrhizic acid or its salt, as tripotassium glycyrrhetate, diammonium glycyrrhizinate.Also can be from buying on the market.
Tannic acid is called tannin again, tannin, and tannin is the class material that molecular weight varies in size, macromole tannic acid degradable is the micromolecule tannic acid, also can obtain by synthetic.Tannic acid can be extracted by various plants, and is first-selected from Galla Chinensis, Fructus rhois chinensis, Pericarpium Granati and banana stalk extraction, the tannic acid that preferred molecular weight is little.
Triclosan has another name called triclosan, and 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers are added to disinfectant or daily chemical product and are used for pressing down antibacterial, fungus and virus extremely, can be from buying on the market.
Glycyrrhizic acid and salt thereof, tannic acid and triclosan compositions by a certain percentage, wherein glycyrrhizic acid or its salt are the 1-50 weight portion, tannic acid is the 1-100 weight portion, triclosan is the 1-30 weight portion, being preferably glycyrrhizic acid or its salt is the 1-30 weight portion, and tannic acid is the 10-90 weight portion, and triclosan is the 1-5 weight portion.
In recent years result of study shows (Chen Fuqiang etc., treatment and prevention of tumour magazine, 2001,8 (4) 342-344; Xu Chengkang, Zhongshan Medical Univ.'s journal, 1998,19 (3): 223-226), 29.3% the patients of cervical ruin HPV positive, and the normal cervix positive rate only is 11.1%.It is reported (Ahn ws et al, J Cell BiochemSuppl, 1997; 28-29:133-139), high-risk HPV (16,18) type expression rate is 69% in the chronic cervicitis.HPV is relevant with multiple disease, it is divided into many hypotypes, according to it to organizing the size of vicious transformation degree, HPV is divided into high, medium and low danger type, wherein high-risk-type comprises HPV16,18, HPV16 is modal hypotype in cervical erosion and the cervical cancer, high-risk HPV 16,18 recall rates present with the increase of the rotten to the corn degree of official's neck and increase progressively trend, granular pattern or papillary erosion HPV16,18 recall rates and normal cervix comparing difference are remarkable, show that cervical cancer and HPV are closely related, closely related with cervical erosion.Can record with PCR in the cervical cancer of 85%-90% high-risk HPV is arranged, HPV16,18 positive rates reach 83.33% in the cervical cancer, high-risk HPV DNA is incorporated into host cell chromosome, can produce E6, E7 oncoprotein, they suppress antioncogene p53 and Rb respectively, make cell escape the control of p53 and Rb, cause cell cycle control not normal, make active, the tumor growth of the hyperplasia that remains static usually.Infect though there is the main trafficability characteristic of most childbearing age women to propagate, have only minority to develop into cervical cancer,, just can make the cervical lesions progress if HPV16 continues to exist.Cervical HPV infection and pudendum infect different, based on the HPV16/18 type, condyloma latum does not often take place change, but with the inapparent infection long-term existence, cause atypical hyperplasia earlier in the palace, when other factors participate in and cause canceration.HPV6/11,16/18 type can be killed and suppress to the compositions of above-mentioned glycyrrhizic acid or its salt, tannic acid and triclosan effectively, can be used for preparing treatment HPV viral infection and medicine, treatment condyloma acuminatum, verruca plana, verruca vulgaris, vagina, cervicitis and cervical erosion.
The present invention observes active component and product effect by the change that real-time fluorescence quantitative PCR detects the amount of HPV virus, and this method is used (Cai Youling etc., Chinese std aids control, 2002,8:2,108 in the several pieces of documents of publishing; Wu Yuansheng, model are auspicious strong etc., and the practical combination of Chinese and Western medicine is clinical, and 2003,3:2,1).
The result shows, the tissue homogenate of condyloma acuminatum after the compositions that adds glycyrrhizic acid or its salt, tannic acid and triclosan 24 hours, FQ-POVR can not detect virus again, and blank pipe and contrast QC have the very HPV virus quantity of high concentration, illustrate that medicine of the present invention and effective ingredient thereof have the ability of the HPV virus of fast and effeciently going out.
Experiment showed, that independent use tannic acid medicinal liquid has inhibition to staphylococcus aureus, escherichia coli and bacillus pyocyaneus, but Candida albicans is not had bacteriostasis.The compositions of glycyrrhizic acid of the present invention or its salt, tannic acid and triclosan then all has inhibition to staphylococcus aureus, escherichia coli, bacillus pyocyaneus and Candida albicans.
The compositions of glycyrrhizic acid of the present invention or its salt, tannic acid and triclosan can prevent and treat the purposes of humans and animals skin mucosa antibacterial, fungus, viral disease and acne medicine simultaneously in preparation, comprise acne, herpes simplex, genital herpes, varicella-zoster, condyloma acuminatum, verruca plana, bacillary, mycotic, viral vaginitis, cervicitis and cervical erosion, particularly treat the purposes of humans and animals skin mucous membrane virus disease medicament.Compositions of the present invention is non-stimulated to skin mucosa, and toxic and side effects is low, and the kind of treatment skin and mucosa infection disease is many, and effect is obvious, and treatment condyloma acuminatum, the about 4-5 of verruca plana days begin progressively to come off.Treatment herpes labialis, herpes zoster, the about 2-3 of genital herpes days incrustation.
The compositions of glycyrrhizic acid of the present invention or its salt, tannic acid and triclosan and contain compositions as glycyrrhizic acid or its salt, tannic acid and the triclosan of active component effective dose, with the application of various supplementary product compatibilities in the various preparations of preparation of skin mucosa medication, can be unguentum, gel, lotion, tablet, suppository, membrane, spray.Can be used for preparing medicine or the disinfectant or the hygienic article of treatment humans and animals skin mucosa antibacterial, fungus, viral infection and acne.
The solids content of the compositions of glycyrrhizic acid or its salt, tannic acid and triclosan is 1-70% in the preparation, is preferably 2-20%.
When being used to prepare pharmaceutical formulation, can make up with different medicine and acceptable carriers, be beneficial to the formation of preparation, in addition, can also add various adjuvants, as surfactant, stabilizing agent, antioxidant, antiseptic and Percutaneous absorption enhancer etc.These carriers and adjuvant can be:
Starch, dextrin, tween 80, carbomer, cellulose, sodium carboxymethyl cellulose, sodium alginate, glycerol, propylene glycol, Polyethylene Glycol, laurocapram, isopropyl alcohol, triethanolamine, sorbester p18, but be not limited thereto.
The pH of the composite preparation of glycyrrhizic acid of the present invention or its salt, tannic acid and triclosan is 1-7, is preferably pH4-6.5.Regulate pH and can use HCl, sulphuric acid, lactic acid, NaOH or KCl.
Below in conjunction with embodiment, further specify the present invention, but the present invention is not limited to these embodiment, any on essence spirit of the present invention improvement or substitute, still belong to desired protection domain in claims of the present invention.
The specific embodiment
Test raw material and medicine source
Glycyrrhizic acid Shaanxi plant development corporation, Ltd. of favour section
Tripotassium glycyrrhetate Gansu Jin Hanbai pharmaceutcal corporation, Ltd
The high biological medicine Science and Technology Ltd. of containing in diammonium glycyrrhizinate Shaanxi
The high biological medicine Science and Technology Ltd. of containing in tannic acid Shaanxi
Triclosan HuBei Hengri Chemical Industry Co.,Ltd.
FUYANJING JIAONANG content (this product is the capsules of flavour of a drug through being processed into such as Radix Picriae felterrae, Elephantopus scaber L., Radix Angelicae Sinensis, Caulis Spatholobi, Radix Zanthoxyli) Guangxi Wuzhou Pharmaceutical Group Plc
Embodiment 1
The preparation of the anti-HPV virus of the compositions of compound glycyrrbizic acid diammonium, tannic acid and triclosan effervescent tablet:
Diammonium glycyrrhizinate 0.20 gram
Tannic acid 1.00 grams
Triclosan 0.10 gram
Tartaric acid 0.45 gram
Sodium bicarbonate 0.65 gram
Dextrin 0.02 gram
PEG6000 0.01 gram
Preparation method: extracting liquorice acid diammonium, tannic acid, triclosan, tartaric acid are crossed 80 mesh sieves respectively, make soft material with 95% ethanol, and the wet grain of the 12 mesh sieve systems of crossing is in 50 ℃ of dryings, standby.Other gets sodium bicarbonate and adds sterile distilled water system soft material, and the wet grain of the 12 mesh sieve systems of crossing in 50 ℃ of dryings, mixes with above-mentioned dry granular then, and granulate adds an amount of sterile purified water, and baking adds PEG6000, dextrin for a moment.Mixing, tabletting.
Embodiment 2
The preparation of compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution:
Tripotassium glycyrrhetate 0.10 gram
Tannic acid 5.00 grams
Triclosan 0.30 gram
1,20 milliliters of 2-propylene glycol
20 milliliters of tween 80s
3 milliliters of azones
HCl or NaOH regulate pH to 5.5
Sterile purified water adds to 100 milliliters
Embodiment 3
The preparation of compound glycyrrbizic acid, tannic acid and triclosan disinfectant solution:
Glycyrrhizic acid 1.00 grams
Tannic acid 5.00 grams
Triclosan 0.50 gram
1,15 milliliters of 2-propylene glycol
15 milliliters of tween 80s
3 milliliters of azones
HCl or NaOH regulate pH to 5.5
Sterile purified water adds to 100 milliliters
Embodiment 4
The preparation of compound glycyrrbizic acid diammonium, tannic acid and triclosan gel:
Diammonium glycyrrhizinate 5.00 grams
Tannic acid 30.00 grams
Triclosan 3.00 grams
Carbomer 10 grams
Glycerol 100 grams
Sterile purified water adds to 1000 milliliters
Preparation method: get the carbomer gradation and be sprinkled in an amount of sterile purified water, make its slow swelling, after adding glycerol is mixed well, drip triethanolamine and stir into residuite, pH transfers to 6.0-6.5.Measure diammonium glycyrrhizinate 5.0 gram, tannic acid 30.0 grams, triclosan 3.00 grams, add in an amount of heat sterilization distilled water, after the dissolving cooling, stir while adding again in gel-type vehicle, add sterile purified water to 1000 milliliter at last, stir evenly packing and get final product.
Embodiment 5
Fluorescence quantitative PCR detection HPV virus drug sensitive experiment
The drug sample preparation:
No. 1: tannic acid 5 gram adds 50 milliliters of dissolvings of distilled water, adds 1 again, and each 20 milliliters of 2-propylene glycol, tween 80s add sterile purified water to 100 milliliter at last, are mixed with 5% solution.
No. 2: (compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution) presses the disinfectant solution of embodiment 2 preparations
No. 3: FUYANJING JIAONANG content 5 grams, add 1,20 milliliters of 2-propylene glycol, 20 milliliters of tween 80s add sterile purified water to 100 at last, are mixed with 5% solution.
The HPV viral source:
From the condyloma acuminatum specimen of multidigit patients clinical standard, after cutting,, under aseptic condition, specimen is shredded with normal saline flush away blood, add 3 times of volume normal saline mixings, to grind to form homogenate standby.Key instrument:
PE7700 type quantitative real time PCR Instrument (comprising computer and software).
Primer and fluorescent probe:
Reach the HPV6 that peace gene clinical diagnosis center provides, 11 and 16,18 type FQ-PCR diagnostic kits.
Test method
Get condyloma acuminatum tissue homogenate 50 microlitres, add various testing sample 50 microlitres respectively by setting grouping.
37 ℃ of incubations 24 hours, by reaching peace gene diagnosis center HPV6, the operating procedure that 11 and 16,18 type FQ-PCR diagnostic kits provide detects then:
FQ-PCR reactions steps: adopt conventional alkaline lysis method of extracting DNA0.2ml to go in the thin-walled reaction tube, add certain density primer, F-PROBE, DNTP, archaeal dna polymerase and buffer etc. simultaneously, with PE7700 fluorescent PCR instrument, after 93 ℃ of 2min give degeneration, by 93 ℃ of 45s, 55 ℃ of 120s carry out 40 circulations repeatedly, and quantitative result is calculated the quantitative result of initial copy number by the computer software automatic analyser.
Virus HPV 6/11 HPVl6/18
The pipe number (copy/ml) (copy/ml)
Blank pipe 1.45 * 10
61.40 * 10
5
No. 1: tannic acid 00
No. 2: 00
(the compound glycyrrbizic acid tripotassium,
Tannic acid and triclosan disinfectant solution)
No. 3: 3.40 * 10
52.30 * l0
4
(property management of FUYANJING JIAONANG content)
The tissue homogenate of condyloma acuminatum is adding tannic acid respectively, behind compound glycyrrbizic acid tripotassium, tannic acid and the triclosan disinfectant solution 24 hours, FQ-POVR can not detect virus again, and and blank pipe and FUYANJING JIAONANG content pipe have the very HPV virus quantity of high concentration, illustrate that compound glycyrrbizic acid tripotassium of the present invention, tannic acid and triclosan disinfectant solution and tannic acid all have the effect that can fast and effeciently kill condyloma acuminatum virus.
Embodiment 6
Antibacterial and fungal drug sensitive experiment
Extracorporeal bacteria inhibitor test
Experiment material:
Bacterial strain: staphylococcus aureus, escherichia coli, bacillus pyocyaneus and Candida albicans.Reagent: nutrient broth medium, nutrient agar, sabouraud's agar.
The drug sample preparation:
Original liquid preparation: weighing tannic acid 5 grams add sterile purified waters to 100 milliliter respectively, get 0.1 milliliter for the tannic acid original liquid with get compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution and be compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution original liquid for 0.1 milliliter.
1. get stock solution 2ml as concentration 1.
2. get stock solution 2ml+ distilled water 2ml, mixing takes out 2ml as concentration 2.
3. get 2. in the operation medicinal liquid 2ml+ distilled water 2ml behind the mixing, mixing takes out 2ml as concentration 3.
4. get 3. in the operation medicinal liquid 2ml+ distilled water 2ml behind the mixing, mixing takes out 2ml as concentration 4.
5. get 4. in the operation medicinal liquid 2ml+ distilled water 2ml behind the mixing, mixing takes out 2ml as concentration 5.
6. get 5. in the operation medicinal liquid 2ml+ distilled water 2ml behind the mixing, mixing takes out 2ml as concentration 6.
Experimental technique
Adopt the plate doubling dilution, the medicinal liquid that has prepared is added respectively in the bactericidal nurishing agar culture medium that is cooled to about 55 ℃, mixing is made the medicine flat board of variable concentrations.
The yellow staphylococcus of depletion, escherichia coli, bacillus pyocyaneus, four kinds of experimental bacteria suspensions of Candida albicans, draw respectively and plant in the pastille flat board of variable concentrations, get four flat boards that do not contain medicinal liquid in addition again and also inoculate four kinds of antibacterials), cultivate 18h, observed and recorded minimal inhibitory concentration MIC for 37 ℃.
The tannic acid medicinal liquid the results are shown in following table 1:
Compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution the results are shown in following table 2:
Experimental result
1, the tannic acid group all has in various degree inhibitory action (seeing the following form) to 3 kinds of antibacterials (staphylococcus aureus, escherichia coli, bacillus pyocyaneus) of experiment.But to the Candida albicans unrestraint.
The antibacterial action of table 1 tannic acid
2, compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution all have in various degree inhibitory action (seeing the following form) to 4 kinds of antibacterials (staphylococcus aureus, escherichia coli, bacillus pyocyaneus, Candida albicans) of experiment.
The antibacterial action of table 2 compound glycyrrbizic acid tripotassium, tannic acid, triclosan disinfectant solution
Embodiment 7
The test of external curing human body skin herpesvirus infection
The various herpesvirus infections of external curing, incrustation is produce effects in 3 days, is effectively in 5 days, 6 days is invalid later on.
Herpes labialis:
22 person-times of herpes labialises are divided into external acyclovir ointment group and compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution group at random, every group 11 people, 10 person-times of compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution group produce effects, effective 1 people; And 1 person-time of acyclovir ointment group produce effects, effective 4 person-times, invalid 6 person-times, both have significant differences.
Herpes zoster:
Herpes zoster 6 people, compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution group 3 people all are produce effects.1 people is effective for the acyclovir ointment group, and 2 people are invalid, use compound glycyrrbizic acid tripotassium, tannic acid and triclosan disinfectant solution instead after, second or three day the incrustation.
Genital herpes
Genital herpes 5 people, all through long-term external acyclovir, imiquimod or take the acyclovir medicine simultaneously, all invalid.Recovery from illness in 3-5 days behind externally used compound tripotassium glycyrrhetate, tannic acid, triclosan disinfectant solution.
Proof compound glycyrrbizic acid tripotassium, tannic acid and triclosan all have the characteristics of instant effect to I and II type herpesvirus infection.
Embodiment 8
The test of treatment human body skin acne
Male 16-30 year 8 people, women 16-30 year 6 people, acne is shown effect repeatedly, inflammatory pimple, pustule, tuberosity, abscess and cicatrix etc. are arranged, wherein male 4 people, women 2 people, through compound glycyrrbizic acid tripotassium, tannic acid and the treatment of triclosan disinfectant solution, all inflammation such as the pimple of case, pustule, abscess disappeared at 2-3 days.And 8 people's externals Viaminate emulsifiable paste is o.3% in addition taken antibiotic simultaneously, inflammation such as pimple, pustule, abscess 2 people of disappearing at 2-3 days, 3 people of disappearing in 5 days, 3 people more than 6 days.Proof compound glycyrrbizic acid tripotassium, tannic acid, triclosan are to acne, and especially the acne vulgaris effect with inflammation is remarkable.
Embodiment 9
The test of treatment human body skin verruca plana
Through being diagnosed as male 16-60 year 5 people of skin verruca plana, women 16-60 year 3 people, once the external other drug was invalid.Through externally used compound tripotassium glycyrrhetate, tannic acid and the treatment of triclosan disinfectant solution, all verruca plana progressively comes off after case 3-4 days, to normal skin is non-stimulated on every side.6 people that all came off in 5-15 days, 2 people that do not come off more than 15 days.At present, verruca plana needs laser or cold therapy more, does not still have external used medicine on the market identical curative effect is arranged.
Claims (10)
1, the application of the compositions of glycyrrhizic acid or its salt, tannic acid and triclosan in preparation prevention and treatment humans and animals skin and mucosa infection medicine and daily chemical product, it is characterized in that mainly containing the compositions of glycyrrhizic acid or its salt, tannic acid and triclosan, wherein glycyrrhizic acid or its salt are the 1-50 weight portion, tannic acid or its salt are the 1-100 weight portion, and triclosan is the 1-30 weight portion.
2, according to the preparation of claim 1, wherein glycyrrhizic acid or its salt are the 1-30 weight portion, and tannic acid or its salt are the 10-100 weight portion, and triclosan is the 1-10 weight portion.
3, according to claim 1, wherein glycyrrhizic acid or its salt are selected from Radix Glycyrrhizae, and tannic acid is preferably from the Galla Chinensis extract of gallotannic acid or effective dose.
4, the application of the compositions of glycyrrhizic acid or its salt, tannic acid and triclosan in preparation prevention and treatment skin mucosa antibacterial, fungus and viral infection medicine is characterized in that mainly containing the compositions of glycyrrhizic acid or its salt, tannic acid and triclosan.
5, the compositions of glycyrrhizic acid according to claim 1 or its salt, tannic acid and triclosan is used to prepare the purposes of preventing simultaneously and treating humans and animals skin mucosa antibacterial, fungus, viral infection and acne medicine.
6, the compositions of glycyrrhizic acid according to claim 1 or its salt, tannic acid and triclosan is used to prepare the purposes of preventing and treating humans and animals skin mucosa staphylococcus aureus, escherichia coli, bacillus pyocyaneus, Candida albicans, herpesvirus, human papilloma virus infection medicine.
7, the compositions of glycyrrhizic acid according to claim 1 or its salt, tannic acid and triclosan is used to prepare the purposes of prevention and treatment application on human skin acne medicine.
8, the compositions of glycyrrhizic acid according to claim 1 or its salt, tannic acid and triclosan is used to prepare the purposes of the disease medicament that prevention and treatment humans and animals skin mucosa human papillomavirus cause, comprises condyloma acuminatum, verruca plana, vagina, cervicitis and cervical erosion.
9, the compositions of glycyrrhizic acid according to claim 1 or its salt, tannic acid, triclosan, with the application of enepidermic various supplementary product compatibilities in the various preparations of preparation, can be other external preparation that unguentum, gel, lotion, tablet, suppository, membrane, spray and pharmacy can be accepted.
10, the compositions of glycyrrhizic acid according to claim 1 or its salt, tannic acid and triclosan is used to prepare the purposes of daily chemical product, nursing materials, cosmetics, can be toothpaste, fancy soap, medicated soap, napkin, cleansing milk, shampoo, liquid detergent.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108042558A (en) * | 2017-12-12 | 2018-05-18 | 长沙拜特生物科技研究所有限公司 | Avermectin preparation used for aquiculture and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042558A (en) * | 2017-12-12 | 2018-05-18 | 长沙拜特生物科技研究所有限公司 | Avermectin preparation used for aquiculture and preparation method thereof |
| CN108042558B (en) * | 2017-12-12 | 2020-02-07 | 长沙拜特生物科技研究所有限公司 | Abamectin preparation for aquaculture and preparation method thereof |
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