CN104521959A - Novel disinfectant prepared from quaternary ammonium salt and alcohol - Google Patents
Novel disinfectant prepared from quaternary ammonium salt and alcohol Download PDFInfo
- Publication number
- CN104521959A CN104521959A CN201410807324.6A CN201410807324A CN104521959A CN 104521959 A CN104521959 A CN 104521959A CN 201410807324 A CN201410807324 A CN 201410807324A CN 104521959 A CN104521959 A CN 104521959A
- Authority
- CN
- China
- Prior art keywords
- quaternary ammonium
- alcohol
- ammonium salt
- thimerosal
- disinfectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses novel disinfectant prepared from quaternary ammonium salt and alcohol. The disinfectant is prepared from alcohol, quaternary ammonium salt, a corrosion inhibitor, a chelating agent and water. The novel disinfectant can be used for killing pathogenic entero becteria and staphylococcus aureus within one minute, wherein the killing log value is larger than 5; the novel disinfectant can be used for killing candida albicans and pseudomonas aeruginosa within three minutes, wherein the killing log value is larger than 5; the novel disinfectant further has an effect of killing aspergillus niger. The novel disinfectant disclosed by the invention is washing-free, has no corrosion to metal products, can be widely applied to sterilizing in the fields such as appliances and food, is free of toxic action on human bodies and animals and suitable for sterilizing the skin of the human bodies and animals, and has a long-lasting bacteriostatic action. When used for sterilizing common articles, the novel disinfectant can replace quaternary ammonium salt disinfectant to shorten the sterilization time to one minute, can take the place of alcohol and iodine disinfects when used for sterilizing the skin, can keep the antibacterial effect for a long time and can effectively protect the skin part from secondary pollution.
Description
Technical field
The present invention relates to a kind of thimerosal, be specifically related to a kind of Novel disinfectant liquid utilizing quaternary ammonium salt and alcohol to prepare.
Background technology
Be 70%-80% according to ethanol content in " GB26373-2010 ethanol disinfection agent sanitary standard " ethanol disinfection agent.Normal conditions ethanol disinfection liquid due to ethanol content high, high volatility, volatilization gas meet naked light easily there is pyrophoricity accident.Once had be reported in patient use ethanol disinfection after operation time, ethanol disinfection liquid meets electric lancet electric spark generation burning accident.High concentration alcohol disinfectant is also likely extremely quick to human body skin.The thimerosal bactericidal effect of 70%-80% ethanol or 65%-80% isopropyl alcohol is good, but it uses and has very important risk.Ethanol or isopropyl alcohol thimerosal are easily subject to environmental influence in transport with the process of storage, and strong volatility thimerosal is easily escaped from Packaging Bottle and causes thimerosal valid density to decline.When determining alcohol is lower than thimerosal normal concentration, Disinfection Effect declines very remarkable.
Quaternary ammonium compound is cationic surfactant, and its sterilization mechanism is: 1. change Membranes permeability, makes thalline dead; 2. there is good surface-active, be gathered in phage surface, affect bacterial metabolism; 3. make protein denaturation; 4. make the enzyme system inactivation of bacterium.Quaternary ammonium disinfectant has inhibitory action to most of bacterium under the concentration of 5mg/L, and concentration 100mg/L just has stronger sterilizing ability.
In quaternary ammonium salt disinfectant development experience multiple stage, bactericidal activity is improving constantly, but still needs just can reach desirable Disinfection Effect longer action time; Quaternary ammonium salt disinfectant is usually containing chlorion or bromide ion in addition, and Long-Time Service has certain corrosivity to equipment; Quaternary ammonium salt thimerosal is to metal ion-sensitive such as calcium magnesium, and calcium ions and magnesium ions easily forms the quaternary ammonium salt salt compound of active more low solubility difference with quaternary ammonium salt cationic, the bactericidal activity of reduction quaternary ammonium salt thimerosal.In use procedure with hard water preparation quaternary ammonium salt thimerosal or in the environment of sterilization objects, there is calcium ions and magnesium ions, have considerable influence to Disinfection Effect.
Alcohol disinfectant is by making the effect energy quick sterilizations such as albuminous degeneration, but because its high volatility, in use the bactericidal action meeting quick disappearance of ethanol, does not have bacteriostasis.Alcohols thimerosal is mainly used in surface disinfection, skin degerming, generally uses wipe method and use dipping sterilization on a small quantity in occupation mode.
Summary of the invention
The object of the present invention is to provide a kind of thimerosal utilizing quaternary ammonium salt and alcohol to prepare.
The technical solution used in the present invention is:
Utilize a thimerosal prepared by quaternary ammonium salt and alcohol, this thimerosal contains 100 ~ 400g/L alcohol, 200 ~ 1000mg/L quaternary ammonium salt, 0.8 ~ 1.0g/L corrosion inhibiter, 200 ~ 800mg/L chelating agent, and surplus is water.
Further, above-mentioned alcohol is selected from least one in ethanol and isopropyl alcohol.
Further, above-mentioned corrosion inhibiter is methenamine or natrium nitrosum.
Further, above-mentioned chelating agent is the one in EDTA, NTA, ATMP, HEDP or its sodium salt.
Further, above-mentioned quaternary ammonium salt is at least one in benzalkonium chloride, benzalkonium bromide, cetyltrimethyl ammonium, two certain herbaceous plants with big flowers base Dimethyl Ammonium, alkyl trimethyl ammonium carbonate.
The invention has the beneficial effects as follows:
1) alcohol and quaternary ammonium salt are prepared thimerosal by the present invention, and the quaternary ammonium salt added and alcohol have the bactericidal action of obvious Synergistic, and new thimerosal will reduce alcohol content in thimerosal, and suitable quaternary ammonium salt content makes thimerosal have good fungistatic effect.New thimerosal will keep the advantage of alcohols thimerosal Quick disinfection, also by widen containing alcohol thimerosal the scope of application and reduce the cost of alcohols thimerosal.New thimerosal avoids the corrosion of quaternary ammonium salt disinfectant liquid to equipment simultaneously, and is sterilized the impact of the calcium ions and magnesium ions that object may exist.
2) the present invention is only containing 200 ~ 400g/L ethanol or isopropyl alcohol or the mixture of the two, far below the content of alcohol in common alcohols (>500g/L) disinfectant.Pathogenic entero becteria, staphylococcus aureus, Pseudomonas aeruginosa, aspergillus niger, Candida albicans etc. can be killed effectively, fast.Alcohol content is low, uses safer.
3) disinfectant that the present invention comprises can replace ethanol disinfection liquid, and the low Disinfection Effect of cost is good, has good bacteriostasis concurrently, can be used for skin degerming process.
4) disinfectant of the present invention is not containing toxic substance, is the disinfectant flushing-free of nuisanceless type, can be widely used in the equipment in the fields such as food and medicine and the thimerosal of common thing table sterilization.
5) disinfectant good stability of the present invention, under 37 DEG C of conditions preserve 90 days, alcohol content and quaternary ammonium salt content rate of descent lower than 5%, the standard of keeping life more than 2 years.
6) thimerosal of the present invention is corrosion-free, almost corrosion-free to materials such as stainless steel, copper, carbon steels.
7) this product environmental protection, not containing environmentally harmful compound in thimerosal, does not almost affect BOD and COD in environment, reaches environment protection emission requirement.
8) thimerosal of the present invention is with quaternary ammonium salt and volatile alcohol for main component, adds corrosion inhibiter and a small amount of auxiliary agent composition.This thimerosal main feature is to kill bacterial propagule fast, the common microbiological such as mould, and the fungistatic effect time is long.Due in thimerosal containing more volatile alcohols, reduce the moisture that brings in disinfecting process to the impact of sterilization objects.
Embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated, but be not limited thereto.
Utilize a thimerosal prepared by quaternary ammonium salt and alcohol, this thimerosal contains 100 ~ 400g/L alcohol, 200 ~ 1000mg/L quaternary ammonium salt, 0.8 ~ 1.0g/L corrosion inhibiter, 200 ~ 800mg/L chelating agent, and surplus is water.
Preferably, described alcohol is selected from least one in ethanol and isopropyl alcohol.
Preferably, above-mentioned corrosion inhibiter is methenamine or natrium nitrosum, most preferably is methenamine.
Preferably, above-mentioned chelating agent is EDTA(ethylenediamine tetra-acetic acid), NTA(NTA), ATMP(ATMP), HEDP(hydroxy ethylene diphosphonic acid) or its sodium salt in one.
Preferably, above-mentioned quaternary ammonium salt is at least one in benzalkonium chloride, benzalkonium bromide, cetyltrimethyl ammonium, two certain herbaceous plants with big flowers base Dimethyl Ammonium, alkyl trimethyl ammonium carbonate.
the preparation method of thimerosal prepared by embodiment 1 ~ 4 quaternary ammonium salt and alcohol
The formula of the thimerosal utilizing quaternary ammonium salt and alcohol to make in table 1 embodiment 1 ~ 4
1) embodiment 1 ~ 4 presses the component content described in table 1 respectively, takes each raw material;
2) take the water of metering and add chelating agent, stirring;
3) in above-mentioned system, add corrosion inhibiter, stir;
4) in above-mentioned system, add quaternary ammonium salt, stir;
5) in above-mentioned system, add alcohol, stir,
6) regulate pH to be 6.0 to 9.0 with phosphate, a kind of thimerosal utilizing quaternary ammonium salt and alcohol to prepare can be obtained.
The thimerosal prepared above-described embodiment below makes further effect detection.
one, product stability detects
(1) experimental technique and outward appearance
By thimerosal 37 DEG C of preservations in insulating box prepared by embodiment 1 ~ 4, preservation 90 days, thimerosal outward appearance was unchanged, was still colourless, transparent.
(2) assay of active ingredient in product
Carry out the mensuration of alcohol content according to " disinfection technology standard " (2002 editions) test related request, often group gets 5 samples, averages.Result of the test is as shown in table 2.
The detection of table 2 thimerosal active ingredient of the present invention alcohol stability
The mensuration of quaternary ammonium salt content is carried out according to " disinfection technology standard " (2002 editions) test related request.Often group gets 5 samples, averages.Result of the test is as shown in table 3.
The detection of table 3 thimerosal active ingredient of the present invention quaternary ammonium salt stability
Result of the test shows, and preserves 90 days under this product 37 DEG C of conditions, and alcohol content and quaternary ammonium salt content rate of descent are lower than 5%, and it is the standard of 2 years that product satisfies the prescriptive period.
two, corrosivity monitor
Metal protection experiment is carried out according to " disinfection technology standard " (2002 editions) requirement.
Sheet metal: stainless steel (specification is shown in GB1220-75), carbon steel (specification is shown in GB700-65), copper (specification is shown in GB2060-80).
The corrosion experiment result of thimerosal to stainless steel, carbon steel, aluminium, copper prepared by Example 1 is as shown in table 4.
Table 4 thimerosal of the present invention detects corrosion of metal
The above results illustrates, product of the present invention is to stainless steel substrates, copper sheet, carbon steel coupon no corrosion.
three, bactericidal effect detects
Thimerosal prepared by Example 1 ~ 4 carries out according to " disinfection technology standard " (2002 editions) requirement by test method, and adopt suspension quantitative bacteric idal experiment, experimental result is as shown in table 5.
The bactericidal effect of table 5 thimerosal of the present invention
Thimerosal of the present invention has good inhibitory action to common germ as can be seen from Table 5, can reach 100% by killing rate, and sterilizing time can be as short as 1min.
Thimerosal prepared by Example 1 is undertaken by " disinfection technology standard " (2002 editions) requirement, and adopt carrier quantitation sterilization (Candida albicans ATCC10231) experiment, experimental result is as shown in table 6.
The bactericidal effect of table 6 thimerosal of the present invention
The above results illustrates that sterilization Huaihe River prepared by the present invention has quick-acting, efficient sterilizing ability, can kill yeast fast, fungi, the common microbiological such as mould, and the fungistatic effect time is long.
four, bactericidal effect contrast verification
Thimerosal prepared by Example 3 and folk prescription quaternary ammonium salt thimerosal, carry out according to " disinfection technology standard " (2002 editions) requirement, adopts suspension quantitative sterilization (Candida albicans ATCC10231) to carry out contrast experiment.The experimental result of table 7 shows, add ethanol in quaternary ammonium salt after, sterilization needs the time obviously to reduce.Killing rate just can be made to reach 100% from the 6min that needs before, after adding ethanol, the killing rate of 2min reaches 100%.
The sterilization contrast experiment of table 7 thimerosal of the present invention
Table 8 compares the impact of calcium ions and magnesium ions on quaternary ammonium salt thimerosal bactericidal effect, and quaternary ammonium salt thimerosal uses the calcium ion containing 2mmol/L, the magnesium ion water preparation of 2mmol/L.There is calcium ions and magnesium ions during thimerosal preparation in experiment, will the bactericidal activity of quaternary ammonium salt be reduced.The experimental result of table 8 illustrates, adds the impact that EDTA can reduce calcium ions and magnesium ions in quaternary ammonium salt thimerosal.
Table 8 calcium ions and magnesium ions is on the impact of quaternary ammonium salt thimerosal sterilization
* note: quaternary ammonium salt A is 400mg/L for containing quaternary ammonium salt thimerosal, containing 0.8g/L EDTA; Quaternary ammonium salt B, for being 400mg/L containing quaternary ammonium salt thimerosal, does not add other composition.
In sum, thimerosal alcohol content prepared by the present invention is low, can kill pathogenic entero becteria fast, staphylococcus aureus, Pseudomonas aeruginosa, wait common microbiological, and the fungistatic effect time is long.
Thimerosal main component ethanol of the present invention or isopropyl alcohol and quaternary ammonium salt are conventional disinfectant liquid for skin, to human body or animal skin non-stimulated not irritated, can replace alcohols thimerosal and use as skin degerming by quick sterilization.Product alcohol content is lower can be used in a big way, and cost is more saved, and sterilizes especially effectively safer in the surgical procedure using electrical equipment.
This product is corrosion-free to stainless steel substrates, copper sheet, carbon steel coupon.Be applicable to food and drink factory, the sterilization of the clean room such as pharmaceutical factory and equipment surface; Be applicable to the ground of public place as station, exhibition place, hospital etc., the sterilization of wall that need sterilization; Also be applicable to the disinfection of Partial Food, as dry fruit peanut, almond, walnut, the cleaning and sterilizing of belt leather melon and fruit etc.
In addition, thimerosal environmental protection of the present invention, wherein not containing environmentally harmful compound, does not almost affect BOD and COD in environment, reaches environment protection emission requirement; And preparation and sterilization process easy, thimerosal of the present invention without the need to dilute can directly use.
For those skilled in the art's easy understand; the foregoing is only the part preferred embodiment of patent of the present invention; not in order to limit the present invention, any amendment done within all the spirit and principles in the present invention, equivalent to replace and improvement etc., within the protection domain all dropping on application claims.
Claims (5)
1. the thimerosal utilizing quaternary ammonium salt and alcohol to prepare, is characterized in that: this thimerosal contains 100 ~ 400g/L alcohol, 200 ~ 1000mg/L quaternary ammonium salt, 0.8 ~ 1.0g/L corrosion inhibiter, 200 ~ 800mg/L chelating agent, and surplus is water.
2. thimerosal according to claim 1, is characterized in that: described alcohol is selected from least one in ethanol and isopropyl alcohol.
3. thimerosal according to claim 1, is characterized in that: described corrosion inhibiter is methenamine or natrium nitrosum.
4. thimerosal according to claim 1, is characterized in that: described chelating agent is the one in EDTA, NTA, ATMP, HEDP or its sodium salt.
5. thimerosal according to claim 1, is characterized in that: described quaternary ammonium salt is at least one in benzalkonium chloride, benzalkonium bromide, cetyltrimethyl ammonium, two certain herbaceous plants with big flowers base Dimethyl Ammonium, alkyl trimethyl ammonium carbonate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410807324.6A CN104521959B (en) | 2014-12-23 | 2014-12-23 | A kind of disinfectant solution utilizing quaternary ammonium salt and alcohol to prepare |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410807324.6A CN104521959B (en) | 2014-12-23 | 2014-12-23 | A kind of disinfectant solution utilizing quaternary ammonium salt and alcohol to prepare |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104521959A true CN104521959A (en) | 2015-04-22 |
| CN104521959B CN104521959B (en) | 2016-09-28 |
Family
ID=52837742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410807324.6A Active CN104521959B (en) | 2014-12-23 | 2014-12-23 | A kind of disinfectant solution utilizing quaternary ammonium salt and alcohol to prepare |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104521959B (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106472501A (en) * | 2016-09-22 | 2017-03-08 | 长兴净安环保科技有限公司 | A kind of quaternary ammonium salt disinfectant solution and preparation method thereof |
| CN108815351A (en) * | 2018-07-11 | 2018-11-16 | 合肥华盖生物科技有限公司 | A kind of efficient and environment-friendly type thimerosal and preparation method thereof |
| CN109673638A (en) * | 2019-01-24 | 2019-04-26 | 大连大学 | A kind of efficient mobile phone thimerosal |
| CN110934144A (en) * | 2019-12-09 | 2020-03-31 | 广东环凯微生物科技有限公司 | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof |
| EP3496540A4 (en) * | 2016-08-11 | 2020-07-15 | Ecolab USA Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| CN111513067A (en) * | 2020-04-29 | 2020-08-11 | 江苏斯微特医药科技有限公司 | Compound alcohol-oxygen-sugar disinfectant |
| CN111529550A (en) * | 2020-04-29 | 2020-08-14 | 江苏斯微特医药科技有限公司 | Preparation method of polysaccharide quick-drying hand disinfectant |
| CN113142203A (en) * | 2021-01-31 | 2021-07-23 | 康圣医疗科技(温州)有限公司 | Preparation method of quaternary ammonium salt antibacterial adhesion polymer long-acting disinfectant |
| CN114557345A (en) * | 2021-05-13 | 2022-05-31 | 北京安洁泰科技有限公司 | Disinfectant and preparation method thereof |
| US11406103B2 (en) | 2016-03-01 | 2022-08-09 | Ecolab Usa Inc. | Sanitizing rinse based on quat-anionic surfactant synergy |
| CN115400158A (en) * | 2022-01-20 | 2022-11-29 | 上海迈之悦生物科技有限公司 | Safe and stable novel medical disinfectant and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836508A (en) * | 2005-03-25 | 2006-09-27 | 黄雅钦 | Novel compound o-Phthalaldehyde microemusion sterilization composition |
| CN101926353A (en) * | 2010-07-07 | 2010-12-29 | 高旭 | Disinfectant in field of food and preparation method |
| CN102077828A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Compound disinfectant containing quaternary ammonium salt |
| CN103013687A (en) * | 2012-12-24 | 2013-04-03 | 中国船舶重工集团公司第七一八研究所 | Foam cleaning disinfectant and preparation method thereof |
-
2014
- 2014-12-23 CN CN201410807324.6A patent/CN104521959B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836508A (en) * | 2005-03-25 | 2006-09-27 | 黄雅钦 | Novel compound o-Phthalaldehyde microemusion sterilization composition |
| CN102077828A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Compound disinfectant containing quaternary ammonium salt |
| CN101926353A (en) * | 2010-07-07 | 2010-12-29 | 高旭 | Disinfectant in field of food and preparation method |
| CN103013687A (en) * | 2012-12-24 | 2013-04-03 | 中国船舶重工集团公司第七一八研究所 | Foam cleaning disinfectant and preparation method thereof |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11406103B2 (en) | 2016-03-01 | 2022-08-09 | Ecolab Usa Inc. | Sanitizing rinse based on quat-anionic surfactant synergy |
| EP3496540A4 (en) * | 2016-08-11 | 2020-07-15 | Ecolab USA Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| US11839209B2 (en) | 2016-08-11 | 2023-12-12 | Ecolab Usa Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| US11044907B2 (en) | 2016-08-11 | 2021-06-29 | Ecolab Usa Inc. | Interaction between antimicrobial quaternary compounds and anionic surfactants |
| CN106472501A (en) * | 2016-09-22 | 2017-03-08 | 长兴净安环保科技有限公司 | A kind of quaternary ammonium salt disinfectant solution and preparation method thereof |
| CN108815351A (en) * | 2018-07-11 | 2018-11-16 | 合肥华盖生物科技有限公司 | A kind of efficient and environment-friendly type thimerosal and preparation method thereof |
| CN109673638A (en) * | 2019-01-24 | 2019-04-26 | 大连大学 | A kind of efficient mobile phone thimerosal |
| CN110934144A (en) * | 2019-12-09 | 2020-03-31 | 广东环凯微生物科技有限公司 | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof |
| CN111529550A (en) * | 2020-04-29 | 2020-08-14 | 江苏斯微特医药科技有限公司 | Preparation method of polysaccharide quick-drying hand disinfectant |
| CN111513067A (en) * | 2020-04-29 | 2020-08-11 | 江苏斯微特医药科技有限公司 | Compound alcohol-oxygen-sugar disinfectant |
| CN113142203A (en) * | 2021-01-31 | 2021-07-23 | 康圣医疗科技(温州)有限公司 | Preparation method of quaternary ammonium salt antibacterial adhesion polymer long-acting disinfectant |
| CN114557345A (en) * | 2021-05-13 | 2022-05-31 | 北京安洁泰科技有限公司 | Disinfectant and preparation method thereof |
| CN115400158A (en) * | 2022-01-20 | 2022-11-29 | 上海迈之悦生物科技有限公司 | Safe and stable novel medical disinfectant and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104521959B (en) | 2016-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104521959B (en) | A kind of disinfectant solution utilizing quaternary ammonium salt and alcohol to prepare | |
| US8691252B2 (en) | Storage-stable, anti-microbial compositions including ceragenin compounds and methods of use | |
| US8940792B2 (en) | Antimicrobial composition and methods for using same | |
| CN109777639B (en) | Preparation for disinfecting and cleaning hard surface of air conditioner and general objects and preparation method thereof | |
| CN111700822A (en) | Skin disinfectant and preparation method thereof | |
| WO2010000744A2 (en) | Use of cationic surfactants as sporicidal agents | |
| JP5711846B1 (en) | Water mold control method in aquaculture water | |
| CN106879592A (en) | Glutaraldehyde Deciquam composite disinfectant | |
| CN107001989A (en) | The clean surface agent of natural origin and disinfectant | |
| AU2013359956A1 (en) | Disinfectant | |
| CN112970752B (en) | Environment-friendly efficient surface disinfectant and preparation method thereof | |
| CN112889820B (en) | Compound quaternary ammonium salt disinfectant and preparation method and use method thereof | |
| CN105836860B (en) | A kind of stable type dioxygen aqueous disinfectant and its application in drinking water disinfection | |
| KR101913718B1 (en) | Compositions for sterilization and disinfection comprising octenidine and benzalconium chloride | |
| CA2883955C (en) | Disinfectant formulation comprising calcium hydroxide and sodium hypochlorite | |
| JP7058490B2 (en) | Antibacterial composition that suppresses viruses, bacteria and fungi | |
| CN104336014A (en) | Composite double-long-chain hyamine disinfectant | |
| CN104488862A (en) | Anion-cation surface-active agent compounded disinfectant technology | |
| CN113940358B (en) | Efficient alcohol-free guanidine compound disinfectant and preparation method thereof | |
| CN104434994A (en) | Mucocutaneous disinfectant | |
| JP2002161011A (en) | Germicide composition | |
| CN104430510B (en) | A kind of chlorine-containing disinfectant with corrosion-mitigation scale-inhibition effect of stabilization | |
| JP5784964B2 (en) | Disinfectant composition and disinfecting method | |
| CN114515255A (en) | Medical and common disinfectant for sterilization and disinfection and disinfectant wet tissue solution | |
| EP1393629A1 (en) | Aqueous disinfecting compositions based on quaternary ammonium monomers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |