CN114557345A - Disinfectant and preparation method thereof - Google Patents
Disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN114557345A CN114557345A CN202110520276.2A CN202110520276A CN114557345A CN 114557345 A CN114557345 A CN 114557345A CN 202110520276 A CN202110520276 A CN 202110520276A CN 114557345 A CN114557345 A CN 114557345A
- Authority
- CN
- China
- Prior art keywords
- disinfectant
- parts
- stirring
- ammonium salt
- chelating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/14—Ethers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a disinfectant and a preparation method thereof, wherein the disinfectant comprises the following components, by weight, 10-40 parts of quaternary ammonium salt, 5-20 parts of alcohol, 0.1-5 parts of chelating agent, 1.5-15 parts of corrosion inhibitor and 0.1-10 parts of nonionic surfactant. The preparation method of the disinfectant comprises the steps of weighing the disinfectant according to parts by weight; adding the mixture into deionized water in a stirring tank, and stirring; adding a corrosion inhibitor and a surfactant to uniformly dissolve the components; adding chelating agent, and stirring. The disinfectant prepared by the invention has the advantages of good sterilization effect, stable performance, low corrosion to equipment and short sterilization time.
Description
Technical Field
The invention relates to the technical field of sanitary disinfection, in particular to a disinfectant and a preparation method thereof.
Background
With the development of economy and social progress, the living environment of human beings becomes increasingly severe, various novel pathogenic microorganisms often appear, and the health of people is seriously harmed. Therefore, there is a need to produce a broad spectrum disinfectant against the emergence of drug resistant pathogens or mutated new viruses.
The quaternary ammonium salt disinfectant is sensitive to metal ions such as calcium and magnesium, the calcium and magnesium ions are easy to form a quaternary ammonium salt compound with reduced activity and poor solubility with quaternary ammonium salt cations, and the bactericidal activity of the quaternary ammonium salt disinfectant is reduced. In addition, the quaternary ammonium salt disinfectant prepared by hard water in the using process of the quaternary ammonium salt disinfectant or calcium and magnesium ions in the environment of a disinfection object have great influence on the disinfection effect.
Disclosure of Invention
The disinfectant provided by the invention has the advantages of good sterilization effect, short sterilization time, low corrosion to equipment, no residue and stable performance.
The above purpose of the invention is realized by the following technical scheme:
the disinfectant comprises, by weight, 40-70 parts of quaternary ammonium salt, 5-20 parts of alcohol, 0.1-5 parts of chelating agent, 0.1-5 parts of corrosion inhibitor and 0.1-10 parts of nonionic surfactant.
Preferably, the quaternary ammonium salt is one or two of benzalkonium chloride, alkyl trimethyl ammonium carbonate and didecyl dimethyl ammonium chloride.
Preferably, the alcohol is one or more of ethanol, sorbitol or phenoxyethanol.
Preferably, the nonionic surfactant is one or more of AEO-7, AEO-9, AP60812, PEG400, dodecyl dimethyl amine oxide and nonylphenol polyoxyethylene ether.
Preferably, the corrosion inhibitor is sulfonated lignin or polyaspartic acid.
Preferably, the chelating agent is one of sodium alpha-glucoheptonate or ethylenediamine tetraacetate.
Preferably, the disinfectant has a pH of 7.2 to 7.8.
The invention provides a preparation method of a disinfectant, which comprises the following steps of weighing the disinfectant according to parts by weight; adding the mixture into deionized water in a stirring tank, and stirring; adding a corrosion inhibitor and a surfactant to uniformly dissolve the components; adding chelating agent, and stirring.
In conclusion, the beneficial technical effects of the invention are as follows:
according to the invention, the quaternary ammonium salt and the alcohol are prepared according to the parts by weight, so that the sterilizing effect of obvious synergy is achieved, a proper amount of the quaternary ammonium salt has a good sterilizing and disinfecting effect and higher stability, the sterilizing effect is enhanced by adding the alcohol, and the influence of calcium and magnesium ions in a sterilized object on the sterilizing effect of the disinfectant is reduced.
Detailed Description
In order to explain the technical content of the present invention in detail, the following examples are further illustrated, but the present invention is not limited thereto.
The disinfectant comprises, by weight, 40-70 parts of quaternary ammonium salt, 5-20 parts of alcohol, 0.1-5 parts of chelating agent, 0.1-5 parts of corrosion inhibitor and 0.1-10 parts of nonionic surfactant.
The quaternary ammonium salt is one or the combination of benzalkonium chloride, alkyl trimethyl ammonium carbonate and didecyl dimethyl ammonium chloride.
The alcohol is one or more of ethanol, sorbitol or phenoxyethanol.
The nonionic surfactant is one or more of AEO-7, AEO-9, APG0812, PEG400, dodecyl dimethyl amine oxide, and polyoxyethylene nonyl phenyl ether.
The corrosion inhibitor is sulfonated lignin or polyaspartic acid.
The chelating agent is one of alpha-glucoheptonate or EDTA salt.
The pH of the disinfectant is 7.2-7.8.
The preparation method of the disinfectant comprises the steps of weighing the disinfectant according to parts by weight; adding the mixture into deionized water in a stirring tank, and stirring; adding corrosion inhibitor and surfactant to dissolve uniformly; adding chelating agent, and stirring.
The first embodiment is as follows: 30% of benzalkonium chloride;
30% of didecyl dimethyl ammonium chloride;
10% of sorbitol;
0.5 percent of phenoxyethanol;
2% of ethylenediamine tetraacetate;
1% of polyaspartic acid;
AEO-92％；
and 24.5% of deionized water.
Example two: 30% of benzalkonium chloride;
30% of didecyl dimethyl ammonium chloride;
40% of deionized water;
the accelerated stability test was carried out according to the method of "Disinfection Specification" (2002 edition 2.2.1.2.14), and the accelerated test was carried out for 14 days using a constant temperature incubator at 54 ℃ with an initial effective compound quaternary ammonium salt content of 385g/L, the effective quaternary ammonium salt content became 384.3g/L after 14 days in example one, the reduction rate was 0.2%, and the effective quaternary ammonium salt content became 379.6g/L after 14 days in example two, the reduction rate was 1.4%.
The first embodiment reduces the rate of decrease of effective disinfecting ingredients and makes the product more stable.
The test was carried out according to the method of Disinfection Specification-2002 edition 2.2.4, and corrosion tests were carried out using carbon steel (GB 700-65), stainless steel (GB1220-75), and aluminum (GB 1173-74). The surface of the metal sheet was polished with 120 # sandpaper, and the metal sheet was immersed for 72 hours (every 24 hours for changing the solution) using the samples of examples one and two, rinsed with deionized water and absolute ethanol, air-dried, and weighed, and the test results of the corrosion rates of the three materials are shown in table 1.
TABLE 1
The corrosiveness of the two pairs of metals in the first comparative example and the second comparative example are reduced, wherein the corrosion rate of the two pairs of aluminum (GB1173-74) in the example is 0.1063mm/a and is moderate corrosion, the corrosion rate of the two pairs of aluminum (GB1173-74) in the example is 0.0163mm/a and is mild corrosion, and the corrosion rate of the two pairs of aluminum (GB1173-74) in the example is reduced. The corrosion rate of the example to carbon steel is reduced compared with the example two.
The first example reduces the corrosion of the complex quaternary ammonium salt to metals after addition of additives, wherein the corrosion rate reduction is more obvious for aluminum and carbon steel.
Example three: 30% of benzalkonium chloride;
30% of didecyl dimethyl ammonium chloride;
10% of sorbitol;
0.5 percent of phenoxyethanol;
4% of sodium alpha-glucoheptonate;
2% of polyaspartic acid;
APG0812 2％；
and 21.5% of deionized water.
Example four: 30% of benzalkonium chloride;
30% of didecyl dimethyl ammonium chloride;
40% of deionized water.
The results of the tests according to the "Disinfection Specification" 2002 edition comparing the third and fourth examples are shown in tables 2 and 3.
TABLE 2
TABLE 3
Comparing the third embodiment with the fourth embodiment, selecting a candida albicans test with stronger resistance, killing by using a suspension method, simultaneously diluting the candida albicans test with water according to the proportion of 1: 10000, wherein the killing rate is close to 2 minutes, and after 10 minutes, the killing rate of the third embodiment is higher than that of the fourth embodiment.
Comparing the third embodiment with the fourth embodiment, the Escherichia coli suspension sterilization test is selected, after organic interference machine BSA with different concentrations is added, and 30g/L or more BSA interference agent is added, the 10-minute killing rate of the third embodiment on Escherichia coli is still more than 99.9999%, and the killing rate of the fourth embodiment on Escherichia coli is reduced.
Example three slightly increased the kill rate of the disinfectant at the same quaternary ammonium salt concentration as example four. And the organic interferents are added, so that the influence of the organic interferents on the third embodiment is obviously reduced, and the sterilization effect and the sterilization stability of the quaternary ammonium salt disinfectant are improved.
The effect of the disinfectant is proved by comparing the stability of the pure ammonium salt or alcohol and the corrosivity of the disinfectant on metal materials by using data in four embodiments.
The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.
Claims (8)
1. The disinfectant is characterized by comprising the following components, by weight, 40-70 parts of quaternary ammonium salt, 5-20 parts of alcohol, 0.1-5 parts of chelating agent, 0.1-5 parts of corrosion inhibitor and 0.1-10 parts of nonionic surfactant.
2. The disinfectant of claim 1 wherein said quaternary ammonium salt is one or a combination of benzalkonium chloride, alkyl trimethyl ammonium carbonate, and didecyl dimethyl ammonium chloride.
3. The disinfectant of claim 1 wherein said alcohol is one or more of ethanol, n-butanol, sorbitol, or phenoxyethanol.
4. The disinfectant of claim 1 wherein said nonionic surfactant is a combination of one or more of AEO-7, AEO-9, APG0812, PEG400, dodecyl dimethyl amine oxide, and nonylphenol polyoxyethylene ether.
5. The disinfectant of claim 1 wherein said corrosion inhibitor is a sulfonated lignin or polyaspartic acid.
6. The disinfectant of claim 1 wherein said chelating agent is one of sodium α -glucoheptonate or edetate.
7. Disinfectant according to claim 1, wherein said disinfectant has a PH of 7.2 to 7.8.
8. A process for the preparation of a disinfectant as claimed in any of claims 1 to 7,
weighing the disinfectant according to the parts by weight; adding the mixture into deionized water in a stirring tank, and stirring; adding a corrosion inhibitor and a surfactant to uniformly dissolve the components; adding chelating agent, and stirring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110520276.2A CN114557345A (en) | 2021-05-13 | 2021-05-13 | Disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110520276.2A CN114557345A (en) | 2021-05-13 | 2021-05-13 | Disinfectant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114557345A true CN114557345A (en) | 2022-05-31 |
Family
ID=81712450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110520276.2A Pending CN114557345A (en) | 2021-05-13 | 2021-05-13 | Disinfectant and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114557345A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114946841A (en) * | 2022-06-16 | 2022-08-30 | 朱福军 | Double-chain quaternary ammonium salt disinfectant and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1255408A (en) * | 1968-06-25 | 1971-12-01 | Borg Warner | Heat-absorbent hygroscopic brines |
| GB9910511D0 (en) * | 1999-05-06 | 1999-07-07 | Medichem International Ltd | A disinfectant/sterilant sporacide formulation |
| CN103749445A (en) * | 2013-12-31 | 2014-04-30 | 中国船舶重工集团公司第七一八研究所 | Compound o-phthalaldehyde disinfection concentrated liquid |
| CN104521959A (en) * | 2014-12-23 | 2015-04-22 | 广东环凯微生物科技有限公司 | Novel disinfectant prepared from quaternary ammonium salt and alcohol |
| CN108617650A (en) * | 2018-07-13 | 2018-10-09 | 北京安洁泰科技有限公司 | A kind of compound disinfectant and preparation method thereof |
| CN110934144A (en) * | 2019-12-09 | 2020-03-31 | 广东环凯微生物科技有限公司 | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof |
-
2021
- 2021-05-13 CN CN202110520276.2A patent/CN114557345A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1255408A (en) * | 1968-06-25 | 1971-12-01 | Borg Warner | Heat-absorbent hygroscopic brines |
| GB9910511D0 (en) * | 1999-05-06 | 1999-07-07 | Medichem International Ltd | A disinfectant/sterilant sporacide formulation |
| GB2355408A (en) * | 1999-05-06 | 2001-04-25 | Medichem Internat Ltd | A sporicidal disinfectant & sterilant formulation comprising a quaternary ammonium salt with an alkyl group containing 8 to 18 carbon atoms |
| CN103749445A (en) * | 2013-12-31 | 2014-04-30 | 中国船舶重工集团公司第七一八研究所 | Compound o-phthalaldehyde disinfection concentrated liquid |
| CN104521959A (en) * | 2014-12-23 | 2015-04-22 | 广东环凯微生物科技有限公司 | Novel disinfectant prepared from quaternary ammonium salt and alcohol |
| CN108617650A (en) * | 2018-07-13 | 2018-10-09 | 北京安洁泰科技有限公司 | A kind of compound disinfectant and preparation method thereof |
| CN110934144A (en) * | 2019-12-09 | 2020-03-31 | 广东环凯微生物科技有限公司 | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114946841A (en) * | 2022-06-16 | 2022-08-30 | 朱福军 | Double-chain quaternary ammonium salt disinfectant and preparation method thereof |
| CN114946841B (en) * | 2022-06-16 | 2023-07-21 | 江西健宝医药科技有限公司 | Double-chain quaternary ammonium salt disinfectant and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6239644B2 (en) | disinfectant | |
| CN111631217A (en) | Low-odor low-corrosivity neutral peroxyacetic acid disinfectant and preparation method thereof | |
| CN111440676A (en) | Foam cleaning agent with disinfection and cleaning functions and preparation method thereof | |
| CN101785460B (en) | O-phthalaldehyde disinfectant and preparation method thereof | |
| CN108570365A (en) | A kind of Air conditioner sterilizing detergent | |
| CN103749445A (en) | Compound o-phthalaldehyde disinfection concentrated liquid | |
| CN112889820B (en) | Compound quaternary ammonium salt disinfectant and preparation method and use method thereof | |
| TWI650308B (en) | Aqueous organosilane solution and method for preserving same | |
| JP4377521B2 (en) | Industrial disinfectant and disinfecting method | |
| CN114557345A (en) | Disinfectant and preparation method thereof | |
| CN110934144B (en) | Disinfectant containing amines and quaternary ammonium salt and preparation method thereof | |
| CN113349201A (en) | Ethanol-gel-free no-wash disinfectant and preparation method thereof | |
| CN111727976A (en) | Corrosion inhibition disinfectant for industrial field | |
| CN108477209A (en) | A kind of thimerosal and preparation method thereof | |
| JP6181403B2 (en) | Water-soluble functional fluid with rot resistance | |
| JPS63131124A (en) | Liquid agent composition for contact lens | |
| US20100324137A1 (en) | Lauric arginate as a contact antimicrobial | |
| CN107711835A (en) | A kind of O-phthalaldehyde disinfectant and preparation method thereof | |
| CN102273451B (en) | Low-foaming flushing type glutaraldehyde disinfectant | |
| JPS5925800B2 (en) | Process for producing a novel addition product of ethylene oxide, propylene oxide or glycide to the reaction product of ε-caprolactam and alkyl alkanediamine | |
| CN111559799B (en) | Multipurpose cleaning bactericide and preparation method and use method thereof | |
| JPS59145296A (en) | Metal working oil | |
| BRPI0613847A2 (en) | HOMOGENEOUS AQUEOUS WOOD PRESERVATIVE COMPOSITION | |
| JP6915235B2 (en) | Patina processing method | |
| CN115836681B (en) | O-phthalaldehyde disinfectant and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Patent of Beijing anjietai Technology Co.,Ltd. The person in charge Document name: Correction notice |
|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |