JP4377521B2 - Industrial disinfectant and disinfecting method - Google Patents
Industrial disinfectant and disinfecting method Download PDFInfo
- Publication number
- JP4377521B2 JP4377521B2 JP2000129202A JP2000129202A JP4377521B2 JP 4377521 B2 JP4377521 B2 JP 4377521B2 JP 2000129202 A JP2000129202 A JP 2000129202A JP 2000129202 A JP2000129202 A JP 2000129202A JP 4377521 B2 JP4377521 B2 JP 4377521B2
- Authority
- JP
- Japan
- Prior art keywords
- general formula
- weight
- alkyl group
- mit
- industrial disinfectant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【０００１】
【発明が属する技術分野】
本発明は、製紙工程等のアルカリ領域で、あるいは繊維油剤、切削油剤、ラテックス類、コーティングカラー、リグニン、澱粉スラリー、澱粉糊、塗料、コーキング剤、染料液等のアルカリ性のものに使用される工業用殺菌剤に関する。
【０００２】
【技術背景】
イソチアゾロン誘導体を用いる工業用殺菌剤として、従来から、種々のものが提案され、実用化されている（例えば、特公昭４６−２１２４０号、同６０−５４２８１号、特公平７−３７３６２号公報等参照）。
【０００３】
ところで、イソチアゾロン誘導体のうち、５−クロル−２−メチル−４−イソチアゾリン−３−オン（以下、「Ｃｌ−ＭＩＴ」と記す）は、優れた殺菌効果を有するものの、水に対する安定性が極めて低いため、単独で使用されることはない。
この安定性を高めるために、２−メチル−４−イソチアゾリン−３−オン（以下、「Ｈ−ＭＩＴ」と記す）との混合物として使用したり（特公平７−３７３６２号公報等）、金属錯体を添加して使用する等の工夫がなされている。
【０００４】
また、Ｃｌ−ＭＩＴは、環境破壊を招く虞れのある塩素を含んでおり、殺菌剤として使用した後の廃棄処分に際して塩素の処理に多大のコストが掛かるばかりか、殺菌剤として使用中にも何らかの要因で解離した塩素による装置構成材の腐食等の懸念もある。
【０００５】
これに対し、Ｈ−ＭＩＴは、このような環境破壊や後処理の問題、あるいは使用中の装置構成材に対する悪影響の問題はないが、Ｃｌ−ＭＩＴに比べて殺菌効果が小さいため、これを単独で使用する例はなく、上記のようにＣｌ−ＭＩＴとの混合物として使用するのが一般的である。
【０００６】
しかも、この混合物中のＨ−ＭＩＴの配合割合は、Ｈ−ＭＩＴ：Ｃｌ−ＭＩＴ＝１：９〜３：９程度と、Ｃｌ−ＭＩＴの量が圧倒的に多く（すなわち、Ｈ−ＭＩＴは、殺菌剤としてよりは、Ｃｌ−ＭＩＴの安定剤として使用されているのが現状であり）、上記のＣｌ−ＭＩＴによる問題を解消することはできない。
【０００７】
加えて、Ｃｌ−ＭＩＴとＨ−ＭＩＴとの混合殺菌剤は、酸性〜中性領域では優れた殺菌効果を示すが、アルカリ領域ではＣｌ−ＭＩＴの分解が生じて殺菌能力が低減する上、アルカリ領域で安定なＨ−ＭＩＴは含有割合が少ないため、優れた殺菌効果を示すことができなくなる。
【０００８】
【発明の目的】
本発明は、環境破壊の原因物質（塩素）を含むＣｌ−ＭＩＴを使用することなく、しかもアルカリ領域で優れた殺菌効果を奏し得る工業用殺菌剤を提供することを目的とする。
【０００９】
【発明の概要】
本発明の工業用殺菌剤は、一般式Ｉで示されるベンゾイソチアゾロン誘導体１〜９９重量部と、一般式ＩＩで示されるイソチアゾロン誘導体９９〜１重量部とを有効成分として含み、かつ５−クロル−２−メチル−４−イソチアゾリン−３−オンを含まず、ｐＨ７．５〜１２の領域で使用されることを特徴とする。
また、本発明の工業用殺菌剤は、前記ベンゾイソチアゾロン誘導体と前記イソチアゾロン誘導体との合計濃度が３〜６０重量％であることが好ましい。この一般式Ｉで示されるベンゾイソチアゾロン誘導体と一般式ＩＩで示されるイソチアゾロン誘導体とを有効成分として上記の割合で含む本発明の工業用殺菌剤は、アルカリ金属、アミン系化合物の何れか一方又は双方を含んでいてもよい。
また、本発明の殺菌方法は、ｐＨ７．５〜１２である殺菌対象物を殺菌する方法であって、前記対象物に前記本発明の工業用殺菌剤を前記有効成分として０．１〜３００００ｐｐｍ添加することを特徴とする。
【００１０】
【化２】
一般式Ｉ
（但し、前記一般式Ｉ中、Ｘは酸素又は硫黄を示し、前記Ｘが酸素の場合、Ｒは炭素数１〜８のアルキル基を示し、前記Ｘが硫黄の場合、Ｒは水素又は炭素数１〜８のアルキル基を示し、また、前記一般式ＩＩ中、Ｒ１、Ｒ２はそれぞれ水素又は炭素数１〜４のアルキル基、Ｒ３は水素、炭素数１〜６のアルキル基、又は炭素数１〜４のアルコキシ基を示す）。
【００１２】
本発明において、一般式Ｉのベンゾイソチアゾロン誘導体と、一般式ＩＩのイソチアゾロン誘導体とを併用することにより、これらの誘導体の相乗作用が奏されて、水に対する安定性も高く、アルカリ領域において分解することもなく、優れた殺菌効果を奏することができる上、使用後の廃棄処分時の処理も、Ｃｌ−ＭＩＴ含有殺菌剤の廃棄処分時の処理に比して、簡単に済む。
【００１３】
一般式Ｉのベンゾイソチアゾロン誘導体（以下、一般式Ｉと略す）は、具体的には、１，２−ベンズイソチアゾリン−３−チオン、２−メチル−１，２−ベンズイソチアゾリン−３−チオン、２−エチル−１，２−ベンズイソチアゾリン−３−チオン、２−プロピル−１，２−ベンズイソチアゾリン−３−オン、２−オクチル−１，２−ベンズイソチアゾリン−３−オン、２−ブチル−１，２−ベンズイソチアゾリン−３−オン、２−メチル−１，２−ベンズイソチアゾリン−３オン等が挙げられる。
【００１４】
一般式ＩＩのイソチアゾロン誘導体（以下、一般式ＩＩと略す）は、具体的には、２−ブチル−５−メチル−４−イソチアゾリン−３−オン、２−メトキシ−４−イソチアゾリン−３−オン、５−エチル−４−イソチアゾリン−３−オン、２−メチル−５−エトキシ−４−イソチアゾリン−３−オン、４，５−ジメトキシ−４−イソチアゾリン−３−オン、２−メチル−４−イソチアゾリン−３−オン等が挙げられる。
【００１５】
一般式Ｉと一般式ＩＩとの併用割合は、重量比で、一般式Ｉ：一般式ＩＩ＝１〜９９：９９〜１、好ましくは１０〜９０：９０〜１０とする。
一般式Ｉが１重量部未満で、一般式ＩＩが９９重量部を超えると、一般式Ｉが相対的に少なくなりすぎて、一般式Ｉと一般式ＩＩとを併用する場合の相乗作用が発現ぜず、所望の殺菌効果を得ることができない。
逆に、一般式Ｉが９９重量部を超え、一般式ＩＩが１重量部未満でも、一般式Ｉが相対的に多くなりすぎて、やはり一般式Ｉと一般式ＩＩとを併用する場合の相乗作用が発現せず、所望の殺菌効果を得ることができない。
【００１６】
一般式Ｉと一般式ＩＩとは、上記の併用割合で溶剤に溶解され、本発明の殺菌剤となる。
この溶剤は、アルカリ領域で使用した場合に所望の殺菌効果を得るに際して弊害がなく、しかも廃棄処分時の処理が簡単なものが好ましく、具体的には、次のようなものが使用できる。
【００１７】
水；プロピレングリコール、トリエチレングリコール、ヘキシルグリコール等のグリコール類；ジエチレングリコール、エチレングリコールモノエチルエーテル、エチレングリコールモノブチルエーテル、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル等のグリコールエーテル類；エチレングリコールジアセテート等のグリコールジエステル類；エチレングリコールモノメチルエーテルアセテート、ジエチレングリコールモノメチルエーテルアセテート等のグリコールエステルエーテル類；メチルアセテート、エチルアセテート、３−メトキシブチルアセテート、２−エトキシメチルアセテート、プロピレンカーボネート、グルタル酸ジメチル等のエステル類；ジメチルホルムアミド等のアミド類；イソホロン等のケトン類；Ｎ−メチル−２−ピロリドン等のピロリドン類；等であり、これらはそれぞれ単独で用いてもよいし、適宜の２種以上を組み合わせて用いてもよい。
【００１８】
中でも、グリコールエーテル類；グリコールジエステル類；グリコールエステルエーテル類；エステル類；アミド類；ケトン類；ピロリドン類をそれぞれ単独で用いるか、これらの中から選択した２種以上を組み合わせて用いるか、あるいはこれらを主成分（具体的には５０容量％以上）とし、副成分（具体的には５０容量％未満）としてグリコール類を組み合わせたものであってもよい。
【００１９】
これらの溶剤中の一般式Ｉと一般式ＩＩとからなる有効成分の濃度は、一般式Ｉと一般式ＩＩの合計濃度（すなわち、有効成分としての濃度）で、１〜８０重量％程度、好ましくは３〜６０重量％程度である。
濃度が低すぎると、本発明の殺菌剤の使用量を多くする必要が生じ、使用対象工程や使用対象物の品質を低下させる虞れがあり、高すぎると、有効成分の分離や沈殿等の不都合が生じる場合がある。
【００２０】
また、本発明の殺菌剤には、一般式Ｉの０℃以下での保存安定性を高め、一般式Ｉのより高濃度での安定性等を得るために、あるいは本発明の殺菌剤を特に水系のものに使用する際の溶解性や分散性を高めるために、ナトリウム、カリウム等のアルカリ金属；エチレンジアミン、ジエチレントリアミン、トリエチレンテトラミン、テトラエチレンペンタミン、ペンタエチレンヘキサミン、ジエタノールアミン、トリエタノールアミン、ジイソプロパノールアミン、トリイソプロパノールアミン、モルホリン、ジエチルアミン等のアミン系化合物を含有させてもよい。
これらは、それぞれ単独で用いてもよいし、２種以上を組み合わせて用いることもできる。２種以上を組み合わせる場合は、アルカリ金属とアミン系化合物とを組み合わせてもよい。
なお、アミン系化合物は、上記のような目的（各種の安定性を得、水系のものへの溶解性や分散性を高める）を達成する上では、特にＨ２Ｎ（ＣＨ２ＣＨ２ＮＨ）ｎＨを使用することが好ましい。
【００２１】
アルカリ金属やアミン系化合物の含有量（アルカリ金属とアミン系化合物とを併用する場合は、これらの合計量）は、少なすぎると、これらを含有させる技術的意義が生ぜず、多すぎても、含有効果が飽和してしまうばかりか、一般式ＩＩの安定性を却って低下させる虞れがあるため、一般式Ｉに対して等モル（１．０倍）〜２倍モル程度、好ましくは等モル〜１．５倍モル程度となるような量が適している。
【００２２】
本発明の殺菌剤は、上記の一般式Ｉと一般式ＩＩとからなる有効成分を上記の溶剤に加え、溶解して調製される。
アルカリ金属やアミン系化合物を含有させる場合は、アルカリ金属やアミン系化合物を上記の溶剤に予め加えて溶解させておき、ここに上記の有効成分を加えて溶解してもよいし、有効成分と共に上記の溶剤に加えて溶解させてもよい。
【００２３】
本発明の殺菌剤は、使用対象工程や使用対象物へ所定量を予め加えて使用したり、所定時間毎に所定量を加えて使用する等、様々な態様で使用されてよい。
このとき、これらの使用対象工程や使用対象物は、酸性〜中性のｐＨ領域であってもよいが、本発明の殺菌剤は、ｐＨ７〜１２、好ましくはｐＨ７．５〜１２の弱アルカリ〜強アルカリ領域において、より効果的に使用できる。
【００２４】
以上の本発明の殺菌剤は、アルカリ領域で繁殖し易いＢａｃｉｌｌｕｓ、Ｐｓｅｕｄｏｍｏｎａｓ、Ｍｉｃｒｏｃｏｃｃｕｓ、Ｆｌａｂｏｂａｃｔｅｒｉｕｍ等の微生物に対して有効に作用する。
本発明の殺菌剤の使用量は、使用対象工程や使用対象物、あるいは使用地域や使用季節等によって種々異なり、一概には決められないが、一般には、一般式Ｉと一般式ＩＩとからなる有効成分が、使用対象工程や使用対象物中に、０．００００１〜３％、好ましくは０．００００２５〜０．０２５％含まれる程度であってよい。
【００２５】
【実施例】
実施例１
先ず、表１に示す配合割合（部は重量部を示す）で、本発明の殺菌剤２、３、５、参考例の１、４，６と比較の殺菌剤７を製造した。
【００２６】
【表１】
次いで、表１に示す各殺菌剤１〜７を滅菌水で希釈し１、５、１０、２０、３０、４０、５０、６０、７０、１００、３３０、６６０、１０００ｐｐｍとなるように各シャーレに入れ、これらのシャーレにｐＨ５、７、９、１０、１２に調整しておいたブイヨン寒天培地を混合して個々に平板培地を調整した。
これらの平板培地に、予め培養しておいた微生物（Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｇｉｎｏｓａ）を接種し、３３℃で４８時間静置した後、微生物に対する最小発育阻止濃度を測定し、結果を表２に示す。
【００２８】
【表２】
表２から明らかなように、本発明の殺菌剤１〜６は、ｐＨ９〜１２のアルカリ領域において優れた殺菌効果を示すことが判る。
【００３０】
実施例２
金属切削油（大同化学工業社製）を煮沸水道水で２０倍に希釈したものの９９重量部に、供試菌源として腐敗した金属切削油を１重量部加えた。このもののｐＨは１０であった。
これに実施例１の表１に示す各殺菌剤１〜７をそれぞれ５００ｐｐｍとなるように添加して、３０℃の恒温器に保存し、３日、７日、２１日後に生菌数を測定し、結果を表３に示す。
【００３１】
【表３】
表３から明らかなように、本発明の殺菌剤１〜６は、ｐＨ１０の強アルカリ性を示す金属切削油に対して優れた殺菌効果を示し、しかもこの殺菌効果が長期間に渡って持続することが判る。
【００３３】
実施例３
ｐＨ１０．２の製紙用デンプン系塗工液９９重量部に、供試菌源として腐敗した製紙用デンプン系塗工液を１重量部加えた。
これに実施例１の表１に示す各殺菌剤１〜７をそれぞれ３５０ｐｐｍとなるように添加して、３０℃の恒温器に保存し、３日、７日、２１日後に生菌数を測定し、結果を表４に示す。
【００３４】
【表４】
表４から明らかなように、本発明の殺菌剤１〜６は、ｐＨ１０．２の強アルカリ性を示す製紙用デンプン系塗工液に対して優れた殺菌効果を示し、しかもこの殺菌効果が比較的長期間に渡って持続することが判る。
【００３６】
【発明の効果】
以上詳述したように、本発明の工業用殺菌剤によれば、ｐＨ７〜１２の弱アルカリ〜強アルカリ領域で優れた殺菌効果を奏することができ、しかもこの優れた殺菌効果を長期間に渡って持続することができる。
また、本発明の工業用殺菌剤は、環境に優しく、従って使用後の廃棄処分時の処理が比較的容易である等の効果を奏することができる。[0001]
[Technical field to which the invention belongs]
INDUSTRIAL APPLICABILITY The present invention is used in an alkaline region such as a papermaking process, or an alkaline material such as a fiber oil agent, a cutting oil agent, a latex, a coating color, a lignin, a starch slurry, a starch paste, a paint, a caulking agent, and a dye solution. It relates to an antibacterial agent.
[0002]
[Technical background]
Various industrial disinfectants using isothiazolone derivatives have been proposed and put to practical use (see, for example, JP-B Nos. 46-21240, 60-54281, and JP-B No. 7-37362). ).
[0003]
By the way, among the isothiazolone derivatives, 5-chloro-2-methyl-4-isothiazolin-3-one (hereinafter referred to as “Cl-MIT”) has an excellent bactericidal effect but has extremely low stability to water. Therefore, it is not used alone.
In order to enhance this stability, it can be used as a mixture with 2-methyl-4-isothiazolin-3-one (hereinafter referred to as “H-MIT”) (Japanese Patent Publication No. 7-37362) or a metal complex. It has been devised such as adding and using.
[0004]
In addition, Cl-MIT contains chlorine that may cause environmental destruction, and not only does it cost a lot to dispose of chlorine after disposal as a disinfectant, but also during use as a disinfectant. There are also concerns such as corrosion of equipment components due to chlorine dissociated for some reason.
[0005]
On the other hand, H-MIT does not have such problems of environmental destruction and post-treatment, or adverse effects on equipment components in use. However, H-MIT has a smaller sterilizing effect than Cl-MIT. In general, it is used as a mixture with Cl-MIT as described above.
[0006]
Moreover, the blending ratio of H-MIT in the mixture is H-MIT: Cl-MIT = 1: 9 to 3: 9, and the amount of Cl-MIT is overwhelmingly large (that is, H-MIT is It is currently used as a stabilizer for Cl-MIT rather than as a disinfectant), and the above-mentioned problems caused by Cl-MIT cannot be solved.
[0007]
In addition, the mixed bactericide of Cl-MIT and H-MIT exhibits an excellent bactericidal effect in the acidic to neutral range, but in the alkaline range, Cl-MIT is decomposed to reduce the bactericidal ability. Since H-MIT, which is stable in the region, has a small content ratio, it cannot exhibit an excellent bactericidal effect.
[0008]
OBJECT OF THE INVENTION
An object of this invention is to provide the industrial disinfectant which can show | play the outstanding bactericidal effect in an alkaline region, without using Cl-MIT containing a causative substance (chlorine) of environmental destruction.
[0009]
Summary of the Invention
Industrial fungicide of the present invention includes a benzisothiazolone derivatives 1-99 parts by weight of the formula I, represented by the general formula II and Louis Sochiazoron derivative 99-1 parts by weight as an active ingredient, and 5- It does not contain chloro-2-methyl-4-isothiazolin-3-one and is used in a pH range of 7.5-12.
Moreover, industrial disinfectant of the present invention, it is preferred that the total concentration before and Kibe down along Sochi Asolo emissions derivatives and the isothiazolone derivative is 3 to 60 wt%. The industrial bactericidal agent of the present invention containing the benzoisothiazolone derivative represented by the general formula I and the isothiazolone derivative represented by the general formula II in the above proportion as active ingredients is either one or both of an alkali metal and an amine compound. May be included.
The sterilization method of the present invention is a method of sterilizing an object to be sterilized having a pH of 7.5 to 12, and the industrial disinfectant of the present invention is added to the object as an active ingredient in an amount of 0.1 to 30000 ppm. It is characterized by doing.
[0010]
[Chemical formula 2]
Formula I
(However, in the said general formula I , X shows oxygen or sulfur, when said X is oxygen, R shows a C1-C8 alkyl group, and when said X is sulfur, R is hydrogen or carbon number. 1 to 8 represents an alkyl group, and in the general formula II, R1 and R2 are each hydrogen or an alkyl group having 1 to 4 carbon atoms, R3 is hydrogen, an alkyl group having 1 to 6 carbon atoms, or 1 carbon atom Represents an alkoxy group of ˜4 ) .
[0012]
In the present invention, when a benzoisothiazolone derivative of the general formula I and an isothiazolone derivative of the general formula II are used in combination, the synergistic action of these derivatives is achieved, and the stability to water is high, and the decomposition occurs in the alkaline region. In addition, an excellent sterilizing effect can be obtained, and the processing at the time of disposal after use is simpler than the processing at the time of disposal of the Cl-MIT-containing disinfectant.
[0013]
Specific examples of the benzoisothiazolone derivative of the general formula I (hereinafter abbreviated as the general formula I) include 1,2-benzisothiazoline-3-thione, 2-methyl-1,2-benzisothiazoline-3-thione, 2 - ethyl-1,2-benzisothiazolin-3-thione, 2-propyl-1,2-benzisothiazolin-3-one, 2-octyl-1,2-benzisothiazolin-3-on-2 - butyl -1 , 2-benzisothiazolin-3-one, 2-methyl-1,2-benzisothiazolin-3-one, and the like.
[0014]
Specific examples of the isothiazolone derivative of the general formula II (hereinafter abbreviated as the general formula II) include 2-butyl-5-methyl-4-isothiazolin-3-one, 2-methoxy-4-isothiazolin-3-one, 5-ethyl-4-isothiazolin-3-one, 2-methyl-5-ethoxy-4-isothiazolin-3-one, 4,5-dimethoxy-4-isothiazolin-3-one, 2-methyl-4-isothiazoline- 3-one etc. are mentioned.
[0015]
The combined ratio of the general formula I and the general formula II is a weight ratio of the general formula I: general formula II = 1 to 99: 99-1, preferably 10 to 90: 90-10.
When the general formula I is less than 1 part by weight and the general formula II exceeds 99 parts by weight, the general formula I becomes relatively small and a synergistic effect is exhibited when the general formula I and the general formula II are used in combination. Therefore, the desired bactericidal effect cannot be obtained.
On the other hand, even if the general formula I exceeds 99 parts by weight and the general formula II is less than 1 part by weight, the general formula I becomes relatively large, and the synergistic effect of the combined use of the general formula I and the general formula II The effect does not appear and the desired bactericidal effect cannot be obtained.
[0016]
General formula I and general formula II are dissolved in a solvent in the above-mentioned combination ratio and become the fungicide of the present invention.
This solvent is preferably free from harmful effects when obtaining a desired sterilizing effect when used in an alkaline region, and can be easily treated at the time of disposal. Specifically, the following can be used.
[0017]
Water; glycols such as propylene glycol, triethylene glycol, hexyl glycol; glycol ethers such as diethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether; glycols such as ethylene glycol diacetate Diesters; glycol ester ethers such as ethylene glycol monomethyl ether acetate and diethylene glycol monomethyl ether acetate; esters such as methyl acetate, ethyl acetate, 3-methoxybutyl acetate, 2-ethoxymethyl acetate, propylene carbonate, dimethyl glutarate; dimethyl Amides such as formamide; Ketones such as isophorone, pyrrolidones such as N- methyl-2-pyrrolidone; and the like, may be used each of which alone, or may be used in combination of two or more as appropriate.
[0018]
Among them, glycol ethers; glycol diesters; glycol ester ethers; esters; amides; ketones; pyrrolidones are used alone, or two or more selected from these are used in combination, or these May be a combination of glycols as a main component (specifically, 50% by volume or more) and a secondary component (specifically, less than 50% by volume).
[0019]
The concentration of the active ingredient consisting of general formula I and general formula II in these solvents is about 1 to 80% by weight, preferably the total concentration of general formula I and general formula II (that is, the concentration as the active ingredient). Is about 3 to 60% by weight.
If the concentration is too low, it is necessary to increase the amount of the disinfectant used in the present invention, which may reduce the quality of the target process and the target object. If the concentration is too high, the active ingredient may be separated or precipitated. Inconvenience may occur.
[0020]
In addition, the fungicide of the present invention includes the fungicide of the present invention in order to enhance the storage stability of the general formula I at 0 ° C. or lower, to obtain stability at a higher concentration of the general formula I, or to the fungicide of the present invention. In order to improve the solubility and dispersibility when used in aqueous systems, alkali metals such as sodium and potassium; ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, pentaethylenehexamine, diethanolamine, triethanolamine, diethanol An amine compound such as isopropanolamine, triisopropanolamine, morpholine, and diethylamine may be contained.
These may be used alone or in combination of two or more. When combining 2 or more types, you may combine an alkali metal and an amine compound.
The amine compound is particularly H 2 N (CH 2 CH 2 NH) in order to achieve the above-mentioned purpose (various stability is obtained and the solubility and dispersibility in an aqueous system are increased). it is preferred to use n H.
[0021]
If the content of the alkali metal or amine compound (the total amount of these when using an alkali metal and an amine compound in combination) is too small, the technical significance of containing these will not occur, In addition to the saturation of the content effect, there is a risk that the stability of the general formula II may be reduced instead, so that it is about equimolar (1.0 times) to 2 times moles, preferably equimolar to the general formula I. An amount of about 1.5 times mole is suitable.
[0022]
The disinfectant of the present invention is prepared by adding an active ingredient consisting of the above general formula I and general formula II to the above solvent and dissolving it.
When an alkali metal or amine compound is contained, the alkali metal or amine compound may be added in advance to the above solvent and dissolved therein, and the above active ingredient may be added and dissolved therein. You may dissolve in addition to said solvent.
[0023]
The disinfectant of the present invention may be used in various modes, such as adding a predetermined amount to a use target process or a target object in advance, or adding a predetermined amount every predetermined time.
At this time, these use object process and use object may be in an acidic to neutral pH range, but the fungicide of the present invention has a pH of 7 to 12, preferably a weak alkali of pH 7.5 to 12. It can be used more effectively in the strong alkali region.
[0024]
The above bactericides of the present invention effectively act against microorganisms such as Bacillus, Pseudomonas, Micrococcus, Flabobacterium and the like which are easily propagated in an alkaline region.
The amount of the disinfectant used in the present invention varies depending on the process to be used, the object to be used, the use area, the use season, etc., and cannot be determined unconditionally, but generally consists of general formula I and general formula II. The active ingredient may be contained in the process to be used and the object to be used in an amount of 0.00001 to 3%, preferably 0.000025 to 0.025%.
[0025]
【Example】
Example 1
First, the bactericides 7 of the present invention and the bactericides 7 in comparison with the reference examples 1, 4 and 6 were produced at the blending ratios shown in Table 1 (parts are parts by weight).
[0026]
[Table 1]
Next, each bactericidal agent 1-7 shown in Table 1 was diluted with sterilized water, and each petri dish was adjusted to 1, 5, 10, 20, 30, 40, 50, 60, 70, 100, 330, 660, 1000 ppm. The bouillon agar medium adjusted to pH 5, 7, 9, 10, 12 was mixed with these petri dishes to individually prepare the plate medium.
These plate media were inoculated with microorganisms previously cultured (Pseudomonas aerginosa) and allowed to stand at 33 ° C. for 48 hours, after which the minimum inhibitory concentration against microorganisms was measured. The results are shown in Table 2.
[0028]
[Table 2]
As is apparent from Table 2, it can be seen that the bactericides 1 to 6 of the present invention exhibit an excellent bactericidal effect in the alkaline region of pH 9 to 12.
[0030]
Example 2
1 part by weight of a metal cutting oil that was spoiled as a test bacteria source was added to 99 parts by weight of a metal cutting oil (manufactured by Daido Chemical Industry Co., Ltd.) diluted 20-fold with boiling tap water. The pH of this product was 10.
To this, each bactericidal agent 1-7 shown in Table 1 of Example 1 was added to 500 ppm and stored in a thermostat at 30 ° C., and the number of viable bacteria was measured after 3 days, 7 days, and 21 days. The results are shown in Table 3.
[0031]
[Table 3]
As is apparent from Table 3, the bactericides 1 to 6 of the present invention exhibit an excellent bactericidal effect with respect to metal cutting oil having a strong alkalinity of pH 10, and this bactericidal effect lasts for a long period of time. I understand.
[0033]
Example 3
To 99 parts by weight of a starch-based coating solution for papermaking having a pH of 10.2, 1 part by weight of a spoiled starch-based coating solution for papermaking was added as a test bacteria source.
To this, each bactericidal agent 1-7 shown in Table 1 of Example 1 was added to 350 ppm, and stored in a thermostatic chamber at 30 ° C., and the number of viable bacteria was measured after 3, 7, and 21 days. The results are shown in Table 4.
[0034]
[Table 4]
As is clear from Table 4, the bactericides 1 to 6 of the present invention have an excellent bactericidal effect on a starch-based coating liquid for papermaking having a strong alkalinity of pH 10.2, and this bactericidal effect is relatively high. It can be seen that it lasts for a long time.
[0036]
【The invention's effect】
As described above in detail, according to the industrial disinfectant of the present invention, an excellent disinfecting effect can be achieved in a weak alkali to strong alkali region having a pH of 7 to 12, and this excellent disinfecting effect can be exhibited over a long period of time. Can last.
Moreover, the industrial disinfectant of the present invention is environmentally friendly, and therefore can exhibit effects such as being relatively easy to dispose of after disposal.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000129202A JP4377521B2 (en) | 2000-04-28 | 2000-04-28 | Industrial disinfectant and disinfecting method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000129202A JP4377521B2 (en) | 2000-04-28 | 2000-04-28 | Industrial disinfectant and disinfecting method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001302418A JP2001302418A (en) | 2001-10-31 |
| JP4377521B2 true JP4377521B2 (en) | 2009-12-02 |
Family
ID=18638511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000129202A Expired - Lifetime JP4377521B2 (en) | 2000-04-28 | 2000-04-28 | Industrial disinfectant and disinfecting method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4377521B2 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4567955B2 (en) * | 2002-08-05 | 2010-10-27 | 日本エンバイロケミカルズ株式会社 | Industrial antibacterial composition |
| AU2004201059B2 (en) * | 2003-03-26 | 2009-06-04 | Rohm And Haas Company | Microbicidal composition |
| JP5194205B2 (en) * | 2004-02-19 | 2013-05-08 | 住化エンビロサイエンス株式会社 | Industrial antibacterial composition |
| EP2351486B1 (en) * | 2004-03-05 | 2014-09-17 | Rohm and Haas Company | Antimicrobial composition containing N(n-butyl)-1,2-benzisothiazolin-3-one |
| JP4502704B2 (en) * | 2004-04-30 | 2010-07-14 | ユニオンケミカル株式会社 | Industrial antiseptic and fungicides containing 1,2-benzisothiazolin-3-one and N-ethylaminoethylamine |
| JP4502701B2 (en) * | 2004-04-30 | 2010-07-14 | ユニオンケミカル株式会社 | Industrial antiseptic and fungicides containing 1,2-benzisothiazolin-3-one and 3-amino-1-propanol |
| JP4606091B2 (en) * | 2004-08-30 | 2011-01-05 | 株式会社ネオス | Preservative for water-soluble metalworking fluid |
| DE102005001566A1 (en) * | 2005-01-13 | 2006-07-27 | Lanxess Deutschland Gmbh | Antimicrobially finished solid preparations |
| JP4707138B2 (en) * | 2005-05-27 | 2011-06-22 | 住化エンビロサイエンス株式会社 | Industrial antibacterial composition |
| EP1772055A1 (en) * | 2005-10-04 | 2007-04-11 | Rohm and Haas France SAS | Synergistic microbicidal compositions comprising a N-alkyl-1,2-benzoisothiazolin-3-one |
| JP4813896B2 (en) * | 2005-12-22 | 2011-11-09 | 株式会社片山化学工業研究所 | Industrial antibacterial agent and industrial antibacterial method using the same |
| JP5108264B2 (en) * | 2006-08-08 | 2012-12-26 | アーチ・ケミカルズ・ジャパン株式会社 | Industrial preservative composition |
| JP4944843B2 (en) * | 2007-07-18 | 2012-06-06 | ローム アンド ハース カンパニー | Microbicidal composition |
| CN106455570B (en) * | 2014-05-16 | 2022-03-15 | 营养与生物科技美国第一有限公司 | Stabilization of isothiazolones in aqueous compositions |
| JP5955899B2 (en) * | 2014-07-16 | 2016-07-20 | 株式会社パイロットコーポレーション | Water-based ink composition for writing instruments and product containing the same |
-
2000
- 2000-04-28 JP JP2000129202A patent/JP4377521B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001302418A (en) | 2001-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4377521B2 (en) | Industrial disinfectant and disinfecting method | |
| US8003823B2 (en) | Halo active aromatic sulfonamide organic compounds and odor control uses therefor | |
| JP2008074850A (en) | 1,2-benzisothiazolin-3-one-based sterilization preparation | |
| JPH0713001B2 (en) | Aqueous disinfectant | |
| JP4567141B2 (en) | Stable microbicide composition | |
| CA2053678A1 (en) | Liquid 1,2-benzoisothiazoline-3-one preparation | |
| JP5095308B2 (en) | Disinfectant composition | |
| JP4245097B2 (en) | Harmful microorganism eradication agent | |
| EP0277402B1 (en) | Biocide | |
| JP2005082596A (en) | Low-salt or salt-free microbicidal composition based on isothiazolone derivative and pyrion disulfide | |
| JP4621401B2 (en) | Stabilized isothiazolone composition and method for stabilizing isothiazolone | |
| US5668083A (en) | Composition containing 3-isothiazolone and stabilizer | |
| EP1922302B1 (en) | Biocidal use of active aromatic sulfonamide compositions | |
| JP2009007306A (en) | Industrial antiseptic agent composition | |
| JP4318543B2 (en) | Industrial sterilization composition | |
| JP2000103707A (en) | Industrial bactericide | |
| JP2661745B2 (en) | Industrial disinfectant and disinfection method | |
| JPH02250805A (en) | Industrial bactericide | |
| JP3733470B2 (en) | Industrial disinfectant and industrial disinfecting method | |
| JP2002338412A (en) | Industrial bactericidal composition and bactericidal method | |
| JP4748773B2 (en) | Disinfectant algicide having ability to prevent discoloration and discoloration prevention method | |
| JP2022509981A (en) | 1,2-Benzothiazolin-3-one aqueous concentrate | |
| JP2003104805A (en) | Liquid halogenated hydantoin microbicidal agent | |
| JP3558368B2 (en) | Aqueous composition containing 3-isothiazolone and stabilizer | |
| JP3728452B2 (en) | Industrial disinfectant / bacteriostatic agent and industrial disinfectant / bacteriostatic method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060127 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20090313 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090317 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090518 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090609 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090807 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20090901 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20090911 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 4377521 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120918 Year of fee payment: 3 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120918 Year of fee payment: 3 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120918 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130918 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |