CN113209212A - Hand disinfectant and preparation method thereof - Google Patents
Hand disinfectant and preparation method thereof Download PDFInfo
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- CN113209212A CN113209212A CN202110453436.6A CN202110453436A CN113209212A CN 113209212 A CN113209212 A CN 113209212A CN 202110453436 A CN202110453436 A CN 202110453436A CN 113209212 A CN113209212 A CN 113209212A
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000004945 emulsification Methods 0.000 claims abstract description 26
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims abstract description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 21
- 150000001413 amino acids Chemical class 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000008213 purified water Substances 0.000 claims abstract description 15
- 239000003906 humectant Substances 0.000 claims abstract description 14
- 239000005708 Sodium hypochlorite Substances 0.000 claims abstract description 10
- 239000011780 sodium chloride Substances 0.000 claims abstract description 10
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 9
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 9
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 229940069521 aloe extract Drugs 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- 235000002961 Aloe barbadensis Nutrition 0.000 claims description 5
- 235000011399 aloe vera Nutrition 0.000 claims description 5
- 239000003651 drinking water Substances 0.000 claims description 5
- 235000020188 drinking water Nutrition 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 238000001223 reverse osmosis Methods 0.000 claims description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 3
- 235000020737 peppermint extract Nutrition 0.000 claims description 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 2
- 244000186892 Aloe vera Species 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 30
- 230000002147 killing effect Effects 0.000 abstract description 15
- 241000894006 Bacteria Species 0.000 abstract description 11
- 239000000686 essence Substances 0.000 abstract description 10
- 230000001954 sterilising effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 239000002085 irritant Substances 0.000 abstract description 4
- 231100000021 irritant Toxicity 0.000 abstract description 4
- 241000700605 Viruses Species 0.000 abstract description 3
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- 238000012360 testing method Methods 0.000 description 28
- 239000000243 solution Substances 0.000 description 12
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- 239000011550 stock solution Substances 0.000 description 8
- 241000222122 Candida albicans Species 0.000 description 7
- 241000588724 Escherichia coli Species 0.000 description 7
- 229940095731 candida albicans Drugs 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 241000191967 Staphylococcus aureus Species 0.000 description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 6
- 235000019345 sodium thiosulphate Nutrition 0.000 description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 229910052801 chlorine Inorganic materials 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 5
- 238000013095 identification testing Methods 0.000 description 5
- 230000003472 neutralizing effect Effects 0.000 description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 5
- 229920000053 polysorbate 80 Polymers 0.000 description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 4
- 244000144927 Aloe barbadensis Species 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 235000010445 lecithin Nutrition 0.000 description 4
- 239000000787 lecithin Substances 0.000 description 4
- 229940067606 lecithin Drugs 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000012086 standard solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229940105902 mint extract Drugs 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 244000060701 Kaempferia pandurata Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 239000006159 Sabouraud's agar Substances 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 235000016390 Uvaria chamae Nutrition 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 239000006161 blood agar Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
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- 239000007788 liquid Substances 0.000 description 1
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- 229910000510 noble metal Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
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- 238000011056 performance test Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a hand disinfectant, which is mainly prepared from sodium hypochlorite, sodium chloride, a pH regulator, a humectant, amino acid, essence and purified water. Hyaluronic acid and herba Menthae extract can also be added. The hand disinfectant is vacuumized in a vacuum emulsification mixer in the preparation process, so that the hand disinfectant is sealed, light-resistant and air-free, the air contact time is reduced, the product performance is stable, and the quality guarantee period can reach 2 years; the amino acid has absorption effect on light, so that hypochlorous acid which is easy to photolyze is more stable. The main effective component of the hand disinfectant provided by the invention is hypochlorous acid, which has killing effect on bacteria, mould and virus, and the killing logarithm value can reach more than 5 within 30s, and the hand disinfectant has no residue on hands after sterilization, is non-irritant, non-toxic and harmless, is used for hand disinfection, and can improve skin quality, smooth skin and remarkably relieve the problem of skin dryness after disinfection.
Description
Technical Field
The invention belongs to the technical field of disinfectant, and particularly relates to a hand disinfectant and a preparation method thereof.
Background
The hand disinfection is to eliminate most of microorganisms on hands by chemicals or other methods, so that the number of common pathogenic bacteria is reduced to a safe level. However, in contrast to sterilization, some bacterial spores, filtering viruses, tuberculosis bacteria, fungi, etc. have had an opportunity to go undetermined. A large body of data shows that maintaining hand hygiene is the most basic, simplest and effective means to effectively prevent and control pathogen transmission, thereby reducing the incidence of nosocomial infections. The hand disinfection mainly contains daily sanitary hand disinfection and the surgical hand disinfection of hospital, and the major ingredients of the hand disinfection liquid commonly used at present have alcohol, biguanide etc. and the transportation is inconvenient, and is flammable and explosive, and the potential safety hazard exists to there is certain irritability to skin, and the hand is dry after long-term the use.
The hypochlorous acid disinfectant is an aqueous solution containing stable hypochlorous acid molecules in a stock solution, and is a high-efficiency disinfectant with wide bactericidal spectrum and strong killing capacity. Hypochlorous acid, a neutral inorganic small molecule, can penetrate cell walls and cell membranes of microorganisms, destroy biological substances such as proteins and nucleic acids of the microorganisms, and cause the microorganisms to die. The using effect of the hypochlorous acid disinfectant is influenced by the content of organic matters, the concentration of the used disinfectant, the temperature, the illumination and other factors, so that more organic matters exist in a disinfection object system, and the sterilization effect is relatively reduced; the disinfectant has increased concentration and temperature, and has enhanced bactericidal effect. The disinfectant containing hypochlorous acid is a non-toxic, harmless, non-irritant, mild and efficient disinfectant, and has no residue after use, so that the disinfectant can completely meet the requirements for hand disinfection.
The hypochlorous acid disinfectant in the market at present is usually an electrolytic method and a chemical method, wherein the electrolytic method for producing hypochlorous acid consumes a large amount of electric energy, and an expensive noble metal electrode is easy to damage, so that the use cost of production equipment is high. In addition, hypochlorous acid solution generated by the electrolysis method has low pH (generally 2-4) and is difficult to accurately control, so that hypochlorous acid is unstable and is easy to decompose, and chlorine gas is generated. The chemical method is to adjust the pH value of hypochlorite to 3-7 to produce hypochlorous acid, but the same problem exists with the electrolytic method, and the prepared hypochlorous acid is unstable. The prepared hypochlorous acid has a very limited shelf life, so the stability problem of the hypochlorous acid is broken through, the market prospect of the hypochlorous acid as a disinfectant is very wide, and the hypochlorous acid has great significance in the field of disinfection.
Disclosure of Invention
The invention aims to solve the problems and provides the hand disinfectant which is not irritant, has good stability, long shelf life and good sterilization effect.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a hand disinfectant, which is mainly prepared from sodium hypochlorite, sodium chloride, a pH regulator, a humectant, amino acid, essence and purified water.
The feed comprises the following raw materials in parts by weight:
furthermore, 0.1-0.5 part of mint extract can be added into the hand disinfectant.
Furthermore, 0.05-0.5 part of hyaluronic acid can be added into the hand disinfectant.
Further, the pH regulator is at least one of hydrochloric acid and phosphoric acid of 0.1 mol/L.
Further, the humectant is aloe extract, aloe vera is adopted, and the concentration of the aloe extract is 1.5 g/ml.
Further, the amino acid is at least one of tyrosine, tryptophan and phenylalanine.
Furthermore, the purified water is prepared by drinking water which sequentially passes through a multi-media filter, an activated carbon filter, a softener and a secondary reverse osmosis device.
The invention also provides a preparation method of the hand disinfectant, which comprises the following steps:
the method comprises the following steps: adding purified water into a vacuum emulsification stirrer, adding sodium chloride from a hopper of the vacuum emulsification stirrer, vacuumizing and stirring;
step two: adding sodium hypochlorite into a vacuum emulsification stirrer from a hopper, vacuumizing and stirring;
step three: slowly adding a pH regulator from a hopper, stirring while adding, regulating the pH value to 3.0-6.5, vacuumizing, and continuously stirring uniformly to react to generate hypochlorous acid;
step four: slowly adding humectant, amino acid and essence from hopper, and stirring.
Further, peppermint extract and hyaluronic acid were slowly added from the hopper in step four.
Further, in the first step and the second step, the stirring speed of the vacuum emulsification stirrer is 20HZ, and the stirring time is 5 min; in the third step, the stirring speed is 20HZ, and the stirring time is 10 min.
Compared with the prior art, the invention has the following advantages: the hand disinfectant is prepared in a vacuum emulsifying mixer, and is vacuumized to ensure sealing, light shielding and no air. The product is in a vacuum state, is sealed, is protected from light and has no air, so that the time for contacting air is reduced, the product performance is stable, and the quality guarantee period can reach 2 years; the aloe extract is natural moisture-keeping and water-locking, can form a smooth film on the surface of skin, and has the functions of diminishing inflammation and healing wounds. The herba Menthae extract can increase fragrance, and also has effects of cooling skin and improving skin elasticity. The amino acid has absorption effect on light, so that hypochlorous acid which is easy to photolyze is more stable. Combined with aloe extract, synergistically enhance anti-inflammatory and repair capabilities. The main effective component of the hand disinfectant provided by the invention is hypochlorous acid, which has killing effect on bacteria, mould and virus, and the killing logarithm value can reach more than 5 within 30s, and the hand disinfectant has no residue on hands after sterilization, is non-irritant, non-toxic and harmless, is used for hand disinfection, and can improve skin quality, smooth skin and remarkably relieve the problem of skin dryness after disinfection.
Detailed Description
The present invention is described in further detail for the purpose of better understanding the objects, structure and function of the invention.
Example 1
A hand disinfectant comprises the following raw materials in parts by weight: 0.05 part of sodium hypochlorite, 0.01 part of sodium chloride, 0.01 part of pH regulator, 0.1 part of humectant, 0.01 part of amino acid, 0.01 part of essence and 100 parts of purified water.
Wherein the pH regulator is 0.1mol/L hydrochloric acid. The amino acid is tryptophan. The humectant is aloe extract, and is aloe vera with concentration of 1.5 g/ml. The purified water is prepared by drinking water which sequentially passes through a multi-media filter, an activated carbon filter, a softener and a secondary reverse osmosis device.
The preparation method comprises the following steps of according to the parts by weight of the raw materials: adding purified water into a vacuum emulsification stirrer, adding sodium chloride from a hopper of the vacuum emulsification stirrer, vacuumizing and stirring, wherein the stirring speed of the vacuum emulsification stirrer is 20HZ, and stirring for 5 min; step two, adding sodium hypochlorite into a vacuum emulsification stirrer from a hopper, vacuumizing and stirring, wherein the stirring speed of the vacuum emulsification stirrer is 20HZ, and the stirring time is 5 min; slowly adding hydrochloric acid from a hopper, stirring while adding, adjusting the stirring speed of the vacuum emulsification stirrer to be 20HZ, stirring for 10min, adjusting the pH value to be 3.0, vacuumizing, continuously stirring, and reacting to generate hypochlorous acid; and step four, slowly adding the humectant, the amino acid and the essence from a hopper, and uniformly stirring to obtain the water-based moisturizing agent.
Example 2
A hand disinfectant comprises the following raw materials in parts by weight: 0.3 part of sodium hypochlorite, 0.25 part of sodium chloride, 0.1 part of pH regulator, 0.25 part of humectant, 0.1 part of amino acid, 0.03 part of essence, 100 parts of purified water, 0.25 part of mint extract and 0.2 part of hyaluronic acid.
Wherein the pH regulator is 0.1mol/L hydrochloric acid. The amino acid is tyrosine. The humectant is aloe extract, and is aloe vera with concentration of 1.5 g/ml. The purified water is prepared by drinking water which sequentially passes through a multi-media filter, an activated carbon filter, a softener and a secondary reverse osmosis device.
The preparation method comprises the following steps of according to the parts by weight of the raw materials: adding purified water into a vacuum emulsification stirrer, adding sodium chloride from a hopper of the vacuum emulsification stirrer, vacuumizing and stirring, wherein the stirring speed of the vacuum emulsification stirrer is 20HZ, and stirring for 5 min; step two, adding sodium hypochlorite into a vacuum emulsification stirrer from a hopper, vacuumizing and stirring, wherein the stirring speed of the vacuum emulsification stirrer is 20HZ, and the stirring time is 5 min; step three, slowly adding hydrochloric acid from a hopper, stirring while adding, regulating the stirring speed of the vacuum emulsification stirrer to be 20HZ, regulating the stirring time to be 10min, regulating the pH value to be 4.5, vacuumizing, continuously stirring, and reacting to generate hypochlorous acid; and step four, slowly adding the humectant, the amino acid, the hyaluronic acid, the mint extracting solution and the essence from a hopper, and uniformly stirring to obtain the mint essence.
Example 3
A hand disinfectant comprises the following raw materials in parts by weight: 0.5 part of sodium hypochlorite, 0.5 part of sodium chloride, 0.2 part of pH regulator, 0.5 part of humectant, 0.2 part of amino acid, 0.1 part of essence, 100 parts of purified water, 0.5 part of mint extract and 0.5 part of hyaluronic acid.
Wherein the pH regulator is 0.1mol/L phosphoric acid. The amino acid is phenylalanine. The humectant is aloe extract, and is aloe vera with concentration of 1.5 g/ml. The purified water is prepared by drinking water which sequentially passes through a multi-media filter, an activated carbon filter, a softener and a secondary reverse osmosis device.
The preparation method comprises the following steps of according to the parts by weight of the raw materials: adding purified water into a vacuum emulsification stirrer, adding sodium chloride from a hopper of the vacuum emulsification stirrer, vacuumizing and stirring, wherein the stirring speed of the vacuum emulsification stirrer is 20HZ, and stirring for 5 min; step two, adding sodium hypochlorite into a vacuum emulsification stirrer from a hopper, vacuumizing and stirring, wherein the stirring speed of the vacuum emulsification stirrer is 20HZ, and the stirring time is 5 min; slowly adding phosphoric acid from a hopper, stirring while adding, adjusting the stirring speed of the vacuum emulsification stirrer to be 20HZ, stirring for 10min, adjusting the pH value to be 6.5, vacuumizing, continuously stirring, and reacting to generate hypochlorous acid; and step four, slowly adding the humectant, the amino acid, the hyaluronic acid and the essence from a hopper, and uniformly stirring to obtain the water-based moisturizing agent.
Experiment one: available chlorine content
1. Test samples: hand sanitizer prepared in example 2.
2. Reagent: a sulfuric acid solution with the concentration of 2 mol/L; potassium iodide solution with the concentration of 100 g/L; starch indicator with concentration of 5 g/L.
3. Standard solution: sodium thiosulfate standard solution with the concentration of 0.1000 mol/L.
The experimental method comprises the following steps: the test was repeated 2 times at an ambient temperature of 20.1 ℃ and a relative humidity of 61% according to the determination of the content of available chlorine in 2.2.1.2.1, technical Specification for Disinfection (2002 edition), with the following results:
and (4) conclusion: the available chlorine content of the hand sanitizer prepared in example 2 was 189 mg/L.
Experiment two: stability test
1. Test samples: hand sanitizer prepared in example 2.
2. The instrument equipment comprises: biochemical incubator, model LBI-300.
3. Reagent: a sulfuric acid solution with the concentration of 2 mol/L; potassium iodide solution with the concentration of 100 g/L; starch indicator with concentration of 5 g/L.
4. Standard solution: sodium thiosulfate standard solution with the concentration of 0.1000 mol/L.
The experimental method comprises the following steps: the test was repeated 2 times at an ambient temperature of 26.9 ℃ and a relative humidity of 70% according to the determination of the content of available chlorine in sterilization specification 2.2.1.2.1 (2002 edition) and the determination of the stability of the sterilized products 2.2.3, and the following results were obtained:
and (4) conclusion: after the hand disinfectant prepared in example 2 is stored at 37 ℃ for 90 days, the available chlorine content is 171.6mg/L, and the storage period of validity of the sample can reach 2 years.
Experiment three: microbiological contamination test
First, equipment
1. Test sample the hand sanitizer prepared in example 2.
2. A test device; a biochemical incubator with the model of SPX-150B; a mould incubator with the model of MJX-160B; pipettes, plates, and the like.
3. Diluent and sterile normal saline.
4. Lactose bile salt fermentation tube, SCDLP culture solution, glucose broth, eosin methylene blue agar plate, cetyl trimethyl ammonium bromide plate, blood agar plate, nutrient agar culture medium, and Sabouraud's agar culture medium.
Second, method
1. The detection is based on the identification test of the disposable sanitary article 2.1.11.2 'Disinfection technical Specification' (2002 edition).
2. The detection conditions are that the ambient temperature is 23.0 ℃ and the relative humidity is 50 percent.
Three, result in
The results of the detection of microbial contamination of the samples were as follows:
| detecting the index | Standard value | Measured value |
| Total bacterial colony count (CFU/g) | ≤200 | 0 |
| Total fungal colony count (CFU/g) | ≤100 | 0 |
| Coliform group bacteria | Cannot be detected | Not detected out |
| Staphylococcus aureus | Cannot be detected | Not detected out |
| Pseudomonas aeruginosa | Cannot be detected | Not detected out |
| Hemolytic streptococcus | Cannot be detected | Not detected out |
Fourth, conclusion
The microbiological indicator detection result of the hand disinfectant prepared in the embodiment 2 meets the requirements of GB 27951-2011 hygienic requirements for skin disinfectants.
Experiment four: kill test for Staphylococcus aureus, Escherichia coli and Candida albicans
First, equipment
1. Test strains: staphylococcus aureus ATCC 6538, Escherichia coli 8099, Candida albicans ATCC 10231. The generation number of the above strains is 4 th generation, and bacterial suspension is prepared by using PBS containing 0.03 mol/L.
2. Test samples: hand sanitizer prepared in example 2.
3. Neutralizing agent: PBS solution containing 0.5% sodium thiosulfate, 0.5% lecithin, 1% Tween 80.
4. Organic interferents: 3% bovine serum albumin.
5. Graduated pipettes, and the like.
Second, method
1. The inspection basis is as follows: specification for disinfection (2002 edition) 2.1.1.5 neutralizer identification test, 2.1.1.7 bacteria quantitative killing test and 2.1.1.9 fungi quantitative killing test.
2. Preparation of bacterial suspension: selecting bacteria with a content of 1 × 108CFU/mL～5×108CFU/mL bacterial suspension was subjected to neutralizer identification test.
3. And (3) identification test of a neutralizer: the test bacteria are respectively escherichia coli and candida albicans.
The test groups are: (1) disinfectant and bacterial suspension; (2) (disinfectant + bacterial suspension) + neutralizer; (3) neutralizing agent + bacterial suspension; (4) (disinfectant + neutralizer) + bacterial suspension; (5) diluent + bacterial suspension; (6) diluent + neutralizer + medium. Diluting the sample stock solution by 2 times in the same ratio as the neutralizing agent, and acting for 30 s. The experiment was repeated 3 times.
4. And (3) killing performance test: according to the quantitative sterilization test of the suspension, the action time of the sample stock solution is 30s, 1min and 1.5min, and the test is repeated for 3 times. The test environment temperature is 22.7 ℃ and the relative humidity is 52%.
Three, result in
1. Neutralizer identification test
(1) Escherichia coli
3 times of repeated experiments prove that the average number of growing colonies in the 1 st group is aseptic growth, and the average number of growing colonies in the 2 nd group is 2.5 multiplied by 103CFU/mL, similar average number of growing colonies in groups 3, 4, and 5, error rate between three groups of 4.04%, and sterile growth in group 6.
Negative control was grown aseptically.
(2) Candida albicans
3 times of repeated experiments prove that the average number of growing colonies in the 1 st group is aseptic growth, and the average number of growing colonies in the 2 nd group is 4.1 multiplied by 103CFU/mL, similar average number of growing colonies in groups 3, 4, and 5, with an error rate of 1.04% between groups, and sterile growth in group 6.
Negative control was grown aseptically.
2. Killing effect on Staphylococcus aureus, Escherichia coli and Candida albicans
3 times of repeated tests prove that the sample stock solution acts for 30s, the killing log values of the sample stock solution to staphylococcus aureus and escherichia coli are both greater than 5.00, and the killing log value of the sample stock solution to candida albicans is greater than 4.00.
Negative control was grown aseptically.
Fourth, conclusion
The hand sanitizer prepared in sample example 2 is used for 1min by taking PBS solution containing 0.5% of sodium thiosulfate, 0.5% of lecithin and 1% of tween 80 as a neutralizer, the killing logarithm value of the hand sanitizer on staphylococcus aureus and escherichia coli is more than 5.00, and the killing logarithm value of the hand sanitizer on candida albicans is more than 4.00, and the hand sanitizer meets the requirements of disinfection technical specification (2002 edition).
And (5) testing: on-site sterilization test (surgical hand)
First, equipment
1. Test samples: hand sanitizer prepared in example 2.
2. Neutralizing agent: PBS solution containing 0.5% sodium thiosulfate, 0.5% lecithin, 1% Tween 80.
3. Comparison sampling solution: 0.1% tween 80 in PBS.
4. A sterile cotton swab, a timer and a graduated pipette.
Second, method
1. The detection basis is as follows: disinfection technical Specification (2002 edition) 2.1.2.6 Disinfection hand disinfection field test
2. Before disinfection: after the two hands of a subject are rubbed fully, the fingers of the left hand of the subject are closed, the subject is soaked in a test tube containing 10mL of diluent by using a sterile cotton swab, after the tube wall is squeezed to be dry, the fingers from the bent surfaces of the five fingers to the finger root are rubbed repeatedly for 2 times, the cotton swab is rotated once for each rubbing, and after sampling, the sampling end of the cotton swab is cut into a neutralizer test tube in a sterile operation mode to be used as a positive control sample.
The right hand was disinfected with a disinfectant after surgical hand cleaning, with an action time set at 3 min. After sterilization, the neutralizing agent was used instead of the diluent, and the natural bacteria remaining on the right hand of the subject were sampled once in the same manner as in the positive control group, and used as a test group sample.
3. The number of the tested persons is 30. The test environment temperature is 22.7 ℃ and the relative humidity is 52%.
Three, result in
The test results of 30 persons show that the hand disinfectant stock solution prepared in example 2 is smeared for 3min, and the killing logarithm value of the natural bacteria on the surface of the surgical hand is greater than 1.00, and the specific results are as follows:
fourth, conclusion
The test results of 30 persons with PBS solution containing 0.5% sodium thiosulfate, 0.5% lecithin and 1% tween 80 as neutralizer show that the hand disinfectant stock solution prepared in sample example 2 is smeared for 3min, and has a killing logarithmic value on natural bacteria on the surface of a surgical hand>1.00. Meets the requirements of GB 27950-2011 hygienic requirements for hand disinfectants. Residual natural bacteria after surgical hand disinfection is less than or equal to 5CFU/cm2And the method conforms to the regulation of GB 15982-2012 'Hospital sanitation Standard'.
It is to be understood that the present invention has been described with reference to certain embodiments, and that various changes in the features and embodiments, or equivalent substitutions may be made therein by those skilled in the art without departing from the spirit and scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.
Claims (10)
1. The hand disinfectant is characterized by specifically comprising the following raw materials in parts by weight:
2. the hand disinfectant as claimed in claim 1, wherein 0.1-0.5 part of peppermint extract is further added to the raw materials.
3. The hand disinfectant as set forth in claim 1, wherein hyaluronic acid is added in an amount of 0.05-0.5 parts.
4. The hand sanitizer according to claim 1, wherein the pH adjuster is at least one of hydrochloric acid and phosphoric acid in an amount of 0.1 mol/L.
5. The hand disinfectant as claimed in claim 1, wherein the moisturizer is aloe extract, aloe vera is adopted, and the concentration of the aloe extract is 1.5 g/ml.
6. The hand sanitizer of claim 1, wherein the amino acid is at least one of tyrosine, tryptophan, and phenylalanine.
7. The hand sanitizer according to claim 1, wherein the purified water is made of drinking water sequentially passing through a multi-media filter, an activated carbon filter, a softener, and a two-stage reverse osmosis device.
8. The preparation method of the hand disinfectant as claimed in claim 1, which comprises the following steps:
the method comprises the following steps: adding purified water into a vacuum emulsification stirrer, adding sodium chloride from a hopper of the vacuum emulsification stirrer, vacuumizing and stirring;
step two: adding sodium hypochlorite into a vacuum emulsification stirrer from a hopper, vacuumizing and stirring;
step three: slowly adding a pH regulator from a hopper, stirring while adding, regulating the pH value to 3.0-6.5, vacuumizing, and continuously stirring uniformly to react to generate hypochlorous acid;
step four: slowly adding humectant, amino acid and essence from hopper, and stirring.
9. The method as claimed in claim 8, wherein the vacuum emulsifying mixer is used in the first and second steps, the mixing speed is 20HZ, and the mixing time is 5 min; in the third step, the stirring speed is 20HZ, and the stirring time is 10 min.
10. The method of claim 8, wherein the peppermint extract and the hyaluronic acid are added slowly from a hopper during step four.
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| CN108159074A (en) * | 2018-01-05 | 2018-06-15 | 广州润虹医药科技股份有限公司 | It is a kind of for hypochlorous acid chitosan Wound-protection liquid of wound healing and preparation method thereof |
| CN112120042A (en) * | 2020-10-16 | 2020-12-25 | 山东众之康生物科技有限公司 | Hypochlorous acid disinfectant with efficient sterilization function and preparation method thereof |
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| CN108159074A (en) * | 2018-01-05 | 2018-06-15 | 广州润虹医药科技股份有限公司 | It is a kind of for hypochlorous acid chitosan Wound-protection liquid of wound healing and preparation method thereof |
| CN112120042A (en) * | 2020-10-16 | 2020-12-25 | 山东众之康生物科技有限公司 | Hypochlorous acid disinfectant with efficient sterilization function and preparation method thereof |
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