CN1245012A - Disinfecting gel containing transparent sodium phytate and its preparing process - Google Patents
Disinfecting gel containing transparent sodium phytate and its preparing process Download PDFInfo
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- CN1245012A CN1245012A CN 98110401 CN98110401A CN1245012A CN 1245012 A CN1245012 A CN 1245012A CN 98110401 CN98110401 CN 98110401 CN 98110401 A CN98110401 A CN 98110401A CN 1245012 A CN1245012 A CN 1245012A
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- gel
- diphenyl ether
- water
- sodium hyaluronate
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Abstract
A process for preparing a disinfecting gel used for human skin or the external surfaces of other articles includes such steps as dissolving a water-insoluble non-ionic disinfectant, such as 2,4,4'-trichloro-2'-hydroxyl diphenylether, in its carrier and adding sodium hyalurate as the new natural moisture-holding lubricant. Its advantages include broad spectrum, high antibacterial effect, no by-effect to skin, and protecting skin.
Description
The invention belongs to the disinfectant technical field, be a kind of gel disinfectant that is mainly used in skin degerming and the sterilization of other article surface, main in order to prevent the contagious infection of various infectious diseases.
During disinfectant, the selection of antibacterial agent is comparatively crucial in preparation, though the kind of antibacterial agent is a lot of at present, really desirable antibacterial agent is few in number, because desirable antibacterial agent has following characteristics: 1. broad spectrum antibacterial; 2. antibacterial ability is strong; 3., not sensitization non-stimulated to human body; 4. processing method is simple, and is cheap etc.
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether is a kind of high-efficiency broad spectrum antibacterial agent, it is to the pathogenicity Gram-positive that causes infection and negative bacterium, fungi; Yeast and virus (as hepatitis A, hepatitis B, rabies virus, AIDS virus HIV etc.) all have to be killed and inhibitory action widely, all effectively same to antibiotic resistant bacteria and non-antibiotic drug-fast bacteria, and can reach sterilization effect under low concentration.
Sodium Hyaluronate is the good natural moisture preserving lubricant of generally acknowledging at present, and skin is had no side effect, and long-term use also can make skin smooth tender.
The objective of the invention is to propose a kind of broad-spectrum high efficacy sterilizing ability that both had, have certain skin care effect again, and the production technology of the disinfectant of being convenient to process.
Another object of the present invention is to propose a kind of prescription of composite disinfectant, and not only Disinfection Effect is good for disinfectant that prescription contains and the more existing disinfectant of other compositions, and remedies the deficiency (bad smell has spread effect etc. to skin) of existing disinfectant.
Technical characterictic of the present invention is to adopt water-pure system as 2,4,4 '-three chloro-2 '-carrier of dihydroxy diphenyl ether, dissolve 2,4 with this, 4 '-three chloro-2 '-dihydroxy diphenyl ether obtains stability disinfectant preferably, because 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether is water insoluble at normal temperatures, and its solvability in alcohol is better, selects the mixed system of water and alcohol for this reason.
Technical characterictic of the present invention also is to have added in the disinfectant natural moisture preserving lubricant Sodium Hyaluronate, and it can carry out moisture-keeping function to skin, has remedied common disinfectant skin is caused this defective of damage, and long-term use also can make skin smooth, tender.
Technical characterictic of the present invention also is to have added this gel of Acritamer 940 in disinfectant, carbomer has fabulous compatibility with skin, smears in skin to have certain lubricated sense.
Prescription of the present invention is: 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether (purity＞99.0%), Acritamer 940, Sodium Hyaluronate, ethanol, 1,2-propane diols, isopropyl alcohol, glycerine, triethanolamine, essence and distilled water, wherein Acritamer 940 can gelatin or hydroxyethylcellulose substitute, essence can be selected for use as required.
The prescription and the amount ranges of gel of the present invention are: with the 100g gelometer, wherein 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether (purity is greater than 99.0%) 0-2g, Acritamer 940 0.05-2g, Sodium Hyaluronate 0.001-0.5g, ethanol 0-80g, 1,2 propane diols 0-80g, isopropyl alcohol 0-80g, glycerine 0-5g, triethanolamine 0.3-2g, essence 0.01-0.08g, all the other are distilled water.
The preparation method of gel of the present invention, by the prescription and the consumption of gel of the present invention, shift to an earlier date 1-2 days Sodium Hyaluronate is immersed in the water, make its dissolving back standby, Acritamer 940 was stirred soluble in water in 1 day in advance, standby, get 2,4 under the normal temperature, 4 '-three chloro-2 '-dihydroxy diphenyl ether is dissolved in the alcohol, after adding dissolving good hyaluronic acid solution and carbomer solution and adding essence, stir, transfer pH value to 5.0-7.5, stir evenly after coagulation and get gel of the present invention with triethanolamine.
Example of the present invention:
1. the preparation method of gel of the present invention: preparation gel, Sodium Hyaluronate is immersed in the distilled water, make its dissolving standby, getting Acritamer 940 is dissolved in the distilled water, be stirred to dissolving fully, standby, other gets 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether is dissolved in and is stirred to fully dissolving in the alcohol, and add consoluet Acritamer 940 solution and dissolved fully and filtered sodium hyaluronate solution, stir evenly, transfer PH6.0-7.0 with triethanolamine, mix can in flexible pipe or plastic bottle, promptly get gel of the present invention.
2. gel of the present invention is in 100g, get 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.3g, 95% ethanol 24g, 1,2 propane diols 25g, Acritamer 940 0.3g, Sodium Hyaluronate 0.03g, triethanolamine 0.8g, essence 0.03g, all the other are distilled water, produce by the method for the invention.
3. gel of the present invention is in 100g, get 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.3g, 95% ethanol 35g, glycerine 5g, Acritamer 940 0.4g, Sodium Hyaluronate 0.05g, triethanolamine 0.8g, essence 0.03g, all the other are distilled water, produce by the method for the invention.
4. gel of the present invention is in 100g, get 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.3g, isopropyl alcohol 30g, glycerine 5g, Acritamer 940 0.35g, Sodium Hyaluronate 0.03g, triethanolamine 0.8g, essence 0.03g, all the other are distilled water, produce by the method for the invention.
5. gel of the present invention gets 2,4 in 100g, 4 '-three chloro-2 '-dihydroxy diphenyl ether 0.3g, 1,2-propane diols 55g, Acritamer 940 0.3g, Sodium Hyaluronate 0.02g, triethanolamine 0.8g, essence 0.03g, all the other are distilled water, produce by the method for the invention.
Claims (10)
1. gel that is used for the sterilization of skin degerming and other article surfaces, it comprises water-fast substantially non-ionic antibacterial type and carrier etc.
2. be halogenated diphenyl ether according to the described antibacterial agent of claim 1.
According to the described halogenated diphenyl ether of claim 2 be 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether.
4. comprise water, low mass molecule alcohol, gel, the lubricant of preserving moisture, essence etc. according to the described carrier of claim 1.
5. comprise ethanol, 1,2 propane diols, isopropyl alcohol etc. according to the described low mass molecule alcohol of claim 4.
6. be selected from polyacrylic polymer, gelatin, hydroxyethylcellulose etc. according to the described gel of claim 4.
7. be selected from Sodium Hyaluronate, glycerine etc. according to the described lubricant of preserving moisture of claim 4.
8. extract or produce according to the optional automatic sundries official of the described Sodium Hyaluronate of claim 7 by microbial fermentation.
9. according to the described gel of claim 1, it is characterized in that every 100g weight contains 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0-2g, carbomer (940) 0.05-2g, Sodium Hyaluronate 0.001-0.5g, ethanol 0-80g, 1,2 propane diols 0-80g, isopropyl alcohol 0-80g, glycerine 0-5g, triethanolamine 0.3-2g, essence 0.01-0.08g, all the other are distilled water.
10. according to the preparation method of the described gel of claim 9, it is characterized in that producing the 100g gel, in advance that Sodium Hyaluronate is soluble in water by prescription of the present invention and consumption, make its dissolving standby, carbomer is soluble in water standby, 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether is dissolved in 1, in 2 propane diols and the alcohol mixeding liquid, wait to dissolve complete back and add carbomer solution, hyaluronic acid solution, essence, add water to required weight and stir evenly, transfer pH value 5.0-7.5 with triethanolamine, stir evenly the back packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110401A CN1088553C (en) | 1998-08-14 | 1998-08-14 | Disinfecting gel containing transparent sodium phytate and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98110401A CN1088553C (en) | 1998-08-14 | 1998-08-14 | Disinfecting gel containing transparent sodium phytate and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1245012A true CN1245012A (en) | 2000-02-23 |
| CN1088553C CN1088553C (en) | 2002-08-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98110401A Expired - Fee Related CN1088553C (en) | 1998-08-14 | 1998-08-14 | Disinfecting gel containing transparent sodium phytate and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1088553C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008094910A3 (en) * | 2007-01-30 | 2008-11-27 | Cypress Pharmaceutical Inc | Hyaluronate compositions |
| CN104922055A (en) * | 2014-03-19 | 2015-09-23 | 张益寿 | Semifluid composition used for lubrication, moisture retention, disinfection and sterilization and application method thereof |
| CN106176581A (en) * | 2016-08-23 | 2016-12-07 | 山东新华医疗器械股份有限公司 | A kind of medical disinfecting curry and preparation method thereof and Special sterilizing bottle |
| CN108094432A (en) * | 2017-12-04 | 2018-06-01 | 杨帮燕 | A kind of family expenses disinfecting towel agent |
| CN110358052A (en) * | 2019-07-23 | 2019-10-22 | 浙江振滔鞋材有限公司 | A kind of antibacterial, ventilating footwear material and its manufacturing method |
| CN111150705A (en) * | 2020-02-28 | 2020-05-15 | 北京蒙博润生物科技有限公司 | Alcohol hyaluronic acid disinfectant and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085106A (en) * | 1993-10-27 | 1994-04-13 | 吴亮 | The ophthalmologic operation visco-elastic material that has fluorescence |
| CN1086590C (en) * | 1996-11-22 | 2002-06-26 | 凌沛学 | Eye drops contg. sodium hyaluronate and preparing method thereof |
-
1998
- 1998-08-14 CN CN98110401A patent/CN1088553C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008094910A3 (en) * | 2007-01-30 | 2008-11-27 | Cypress Pharmaceutical Inc | Hyaluronate compositions |
| CN104922055A (en) * | 2014-03-19 | 2015-09-23 | 张益寿 | Semifluid composition used for lubrication, moisture retention, disinfection and sterilization and application method thereof |
| WO2015139333A1 (en) * | 2014-03-19 | 2015-09-24 | 张益寿 | Semi-fluid composition for lubricating, moisturizing, disinfecting and sterilizing and method of use thereof |
| CN106176581A (en) * | 2016-08-23 | 2016-12-07 | 山东新华医疗器械股份有限公司 | A kind of medical disinfecting curry and preparation method thereof and Special sterilizing bottle |
| CN108094432A (en) * | 2017-12-04 | 2018-06-01 | 杨帮燕 | A kind of family expenses disinfecting towel agent |
| CN110358052A (en) * | 2019-07-23 | 2019-10-22 | 浙江振滔鞋材有限公司 | A kind of antibacterial, ventilating footwear material and its manufacturing method |
| CN111150705A (en) * | 2020-02-28 | 2020-05-15 | 北京蒙博润生物科技有限公司 | Alcohol hyaluronic acid disinfectant and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1088553C (en) | 2002-08-07 |
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