CN105596235A - Novel milk cow nipple medicated bath solution and preparing method thereof - Google Patents

Abstract

The invention belongs to the field of animal husbandry, and relates to a novel milk cow nipple medicated bath solution and a preparing method thereof, in particular to a milk cow nipple medicated bath solution. The purpose is to provide the novel milk cow nipple medicated bath solution which has good non-drippage performance, a good bactericidal effect and skin moisturizing and moisture preserving effects and has no stimulation to the skin. The medicated bath solution is prepared from, by mass, 60-88 parts of purified water, 4-32 parts of alcohol, 0.8-1.2 parts of a mobility stabilizer, 0.2-0.4 part of a guanidine disinfectant, 4-6 parts of emollient, 0.1-0.2 part of an emulsifying agent and 0.1-0.2 part of decontaminant. The emollient is prepared from vegetable oil and a natural humidifying factor, the vegetable oil is at least one of natural extracted olive oil, linseed oil, jojoba oil and shea butter, and the natural humidifying factor is at least one of sodium lactate, amino acid, fatty acid and trehalose. The milk cow nipple medicated bath solution has no stimulation to the skin, will not solidify under the low-temperature condition, has good skin moisturizing and moisture preserving effects and has good non-drippage performance and the good bactericidal effect.

Description

A kind of Novel milk cow teats dip and preparation method thereof

Technical field

The present invention relates to animal husbandry field, relate in particular to a kind of milk cow nipple medicated bath liquid.

Background technology

Milk since ancient times, is described as " white blood ", the milk of the milk cow ability output high-quality of healthy high-quality. OrderBefore, dairy is development on a large scale, and its prospect is considerable. But mammitis is one of four large diseases of milk cow, spyBe not that the recessive mastitis incidence of disease is high, harm is large, this disease not only affects the health of milk cow, harm consumer's interests, and directlyReduce the economic interests of the output of milk and milk cattle cultivating, had a strong impact on the development of dairy. Conventionally the precautionary measures of taking are doneMilk well health, create good hygienic conditions, strengthen milk cow immunity etc., the health of doing well to milk is of paramount importance oneIndividual aspect, dipping 30s before milking, milk after the step of lasting dipping sterilization be indispensable. Therefore, scientific and effective nippleDipping sterilization is an important step of prevention mammitis, can effectively reduce incidence, minimizing economic loss, the guarantor of mammitisDemonstrate,prove former milk quality.

Traditional medicine body lotion has iodine, PVP-I, hydrogen peroxide and quaternary ammonium salts disinfectant, and bactericidal effect is good, in marketUpper for a long time popular. These dipping products probably can be divided into several classes: a class is the dip of alcohol as disinfectant solvent; One classIt is the dip that contains film forming material; The Operand dip using glycerine as moisturizing material mostly in addition.

Current above-mentioned some defects of dip ubiquity, for example alcohol, as the dip of disinfectant solvent, can stimulateSkin of nipple, causes skin to occur degreasing phenomenon, thereby affects former milk quality; And the dip that contains film forming material, freezing pointHigher, under cryogenic conditions, easily solidify, although bacterium is had to certain iris action, wrap up in the film forming matter that is attached to mammilla of milk cattleOften thicker and cause skin of nipple airtight, the effect of moisturizing moisturizing is had a greatly reduced quality.

PVP-I is as the disinfectant of conventional milk cow nipple medicated bath liquid, and it has higher bactericidal action, wherein glycerineBe the object that plays moisturizing with the mechanism of moisture absorption, moisturizing effect is single, therefore contains the Operand of glycerine as moisturizing materialDip skin effect is not ideal enough, and long-time dipping meeting causes the dry and cracked of cow papillary skin.

Vegetable oil and NMF are usually used in making up and have the effect of nourishing, moisturizing in washing product, special in ChinaIn profit CN104013561A, mention the use of olive oil, sodium lactate, play the effect of nourishing conditioning hair and scalp, but itsDo not mention the composite of olive oil and sodium lactate and the use in disinfectant system, and find vegetable oil and iodine, PVP-IThere is chemical reaction slowly in composite meeting, makes composite rear system not have moisturizing and disinfective action.

HPG, propylene glycol alginate, shitosan and derivative thereof are usually using cancellated mechanism as increasingThick dose, thixotropic agent use separately, play the effect of stabilising system mobility, but find to be used in dip system to go outExisting two kinds of extreme phenomenons, the one, but using the large guar gum class of the little denseness of viscosity, such material easily solidifies, and does not therefore haveMobility, not only causes and uses difficulty, and easily entirety drops from animal skin, and the 2nd, use that viscosity is large and denseness is littlePropylene glycol alginate, shitosan and derivative thereof, although have mobility, this mobility is unstable, is coated to skinWhen upper, easily there is drip phenomenon, and caused the waste of dip, remote-effects dipping effect.

The mastitis for milk cows incidence of disease is having squeezed after milk in this before nipple closure 30 minutes, at present also the highest timeThere is not one can avoid above shortcoming, can play again the work that good moisturizing effect, sterilizing and obstruct bacterium are invaded simultaneouslyWith dip.

Summary of the invention

The object of the present invention is to provide a kind of have good not drippage property and bactericidal effect, simultaneously non-stimulated to skinAnd the Novel milk cow teats dip of skin-moistening effect.

The invention provides a kind of Novel milk cow teats dip, formed by the material of following mass parts:

Purified water 60-88 part;

Emollient 4-6 part;

Mobility stabilizing agent 0.8-1.2 part;

Guanidine class disinfectant 0.2-0.4 part;

Alcohols 4-32 part;

Detergent 0.1-0.4 part;

Described emollient is made up of vegetable oil and natural moisturizing factor, and the mass ratio of described vegetable oil and NMF is 9:2～6:5, olive oil, linseed oil that described vegetable oil is natural extraction, in Jojoba Oil, shea butter, at least one, described daySo the damping factor is at least one in sodium lactate, amino acid, aliphatic acid, trehalose.

Described mobility stabilizing agent is by one and water in the former powder of guar gum, cation guar gum, HPGAt least one in soluble chitosan, chitosan derivatives, propylene glycol alginate, bassora gum, lauric acid amide of ethanol is by matterAmount forms than 5:1～7:5 is composite.

Described chitosan derivatives is chitosan hydrochloride, hydroxypropyl chitosan, hydroxyethyl chitosan, CMCIn at least one.

Described guanidine class disinfectant is cationic surfactant.

Described cationic surfactant is acetic acid chlorhexidine, gluconic acid chlorhexidine, hexamethylene(PHMB), polyhexamethylene list guanidine hydrochloride (PHMG), polyaminopropyl biguanide (PAPB), few [2-(2-ethyoxyl)-ethyoxyl secondEster] at least one in chlorination guanidine.

Described alcohol is 1,3-PD, 1,2-PD, polyethylene glycol, butanediol, glycerine, polypropylene glycol, sorbieriteIn at least one.

The HLB value of described detergent is in 8～16 scopes.

Described detergent is polysorbate, methyl glucamine, alkylolamides, APG (APG), poly alkyl alcoholIn oxygen vinethene at least one.

Also comprise pigment, its mass parts is 0.05-0.06 part, and described pigment is fruit green, egg yolk, sunset yellow, light blueIn at least one.

The present invention also provides the preparation method of above-mentioned Novel milk cow teats dip, comprises the steps:

(1) preparation of disinfectant premixed liquid: guanidine class disinfectant is joined in 10-13 mass parts purified water and is uniformly mixed;

(2) preparation of mobility stabilizing agent dispersion liquid: mobility stabilizing agent is mixed with 3-26 mass parts alcohols, stirObtain dispersion liquid;

(3) preparation of emollient emulsion: after emollient and 1-6 mass parts alcohols are mixed, then join 10-13 mass partsWater in, grind 15min homogenizing through colloid mill and obtain emollient emulsion;

(4) homogenize: the disinfectant premixed liquid that step (1) is obtained, dispersion liquid, the step (3) that step (2) obtains obtainEmulsion, detergent, pigment join in 40-62 mass parts purified water, after stirring at ambient temperature, through colloid successivelyMill grinds after 30min, and continues to stir 2h, leaves standstill 2h, obtains Novel milk cow teats dip.

The present invention has following beneficial effect:

Dip of the present invention is non-stimulated to skin, can not solidify under cryogenic conditions simultaneously, and moisturizing moisture-keeping function is good, has simultaneouslyGood not drippage property and bactericidal effect.

Brief description of the drawings

Fig. 1 is that measured object is to moisture of skin influence curve figure.

Detailed description of the invention

Below by the specific embodiment providing, the present invention will be further described, but not as a limitation of the invention.

The invention provides a kind of Novel milk cow teats dip, formed by the material of following mass parts:

Purified water 60-88 part;

Emollient 4-6 part;

Mobility stabilizing agent 0.8-1.2 part;

Guanidine class disinfectant 0.2-0.6 part;

Alcohols 4-32 part;

Detergent 0.1-0.4 part;

Dip Raw of the present invention is all food stage or pharmaceutical grade.

In dip of the present invention, emollient is made up of vegetable oil and natural moisturizing factor, vegetable oil and natural guarantor in emollientThe adding proportion scope of the wet factor is 9:2～6:5.

In described emollient, the adding proportion scope of vegetable oil and NMF is 9:2～6:5. In dip systemUnder the constant prerequisite of other components and consumption and emollient total amount, the excessive (> of adding proportion of vegetable oil and NMF9:2), represent that vegetable oil consumption is too much, when low temperature, in oil-in-water dip system, occur separating out phenomenon, and under normal temperature conditionSystem mobility becomes large and occurs serious drip phenomenon; And ratio too small (< 6:5) represents that NMF consumption is too much,Although good in the sex expression of cryogenic conditions current downflow, there is a drip phenomenon normal temperature condition is can mobility excessive.

Vegetable oil of the present invention is olive oil, the linseed oil of natural extraction, at least one in Jojoba Oil, shea butterKind, permeability is strong but non-greasy has the effect of moistening skin-care.

Natural moisturizing factor of the present invention (NMF), is called again NMF, can help to repair damaged skin, improves skinState, safe and non-stimulating. Described natural moisturizing factor is at least one in sodium lactate, amino acid, aliphatic acid, trehalose.

The present invention adopts at least one in sodium lactate, amino acid, aliphatic acid, trehalose, refers in dip system,The double action of the moisture preservative of the system that plays own and maintenance cow papillary skin moisture, can further strengthen moisturizing effectReally.

In the present invention, mobility stabilizing agent is that the former powder of guar gum, cation guar gum, HPG, water soluble shells are poly-In sugar, chitosan derivatives, propylene glycol alginate, bassora gum, lauric acid amide of ethanol at least two kinds, play improvement systemThe effect of mobility, is easy to dip and extrudes from medicated bath cup, dips in rear evenly wrapping up in and is attached on skin of nipple, avoids system drop to occurThe waste of dripping and cause.

In the present invention, mobility stabilizing agent is by the one in the former powder of guar gum, cation guar gum, HPGWith at least one in water soluble chitosan, chitosan derivatives, propylene glycol alginate, bassora gum, lauric acid amide of ethanolComposite forming, its compound proportion scope is 5:1～7:5.

In the present invention, chitosan derivatives is chitosan hydrochloride, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl shellAt least one in glycan.

In the present invention, guanidine class disinfectant is all cationic surfactant, and the advantage that is different from Operand is soluble in waterAnd without alcohol come hydrotropy,, Heat stability is good non-stimulated to skin, with emollient without any chemical reaction, has a broad antifungal spectrum, canMost Grain-positives and negative bacteria are had to killing action.

In the present invention, guanidine class disinfectant can prevent that the corruption of the organic substance such as grease and carbohydrate lost efficacy, and can deposit again uniformlyBe, in the network structure of mobility stabilizing agent, finally to reach the effect of stabilising system.

In the present invention, cationic surfactant is hexamethylene (PHMB), acetic acid chlorhexidine, grapeSaccharic acid chlorhexidine, polyhexamethylene list guanidine hydrochloride (PHMG), polyaminopropyl biguanide (PAPB), few [2-(2-ethyoxyl)-ethoxyBase ethyl ester] at least one in chlorination guanidine.

Alcohol described in the present invention is 1,3-PD, 1,2-PD, polyethylene glycol, butanediol, glycerine, poly-the third twoAt least one in alcohol, sorbierite.

The HLB value of detergent described in the present invention is in 8～16 scopes.

In the present invention, detergent is polysorbate, methyl glucamine, alkylolamides, APG (APG), fatAt least one in the nonionics such as alcohol APEO or cationic surfactant, has the works such as emulsification, solubilising, decontaminationWith, can effectively reduce the surface tension of dirt, dirt is more easily removed, nipple is more clean, makes disinfectant more easily contact skinSkin surface kill bacteria.

In the present invention, also add pigment, its mass parts is 0.05-0.06 part, and described pigment is fruit green, egg yolk, sunsetIn Huang, light blue, sodium zinc chlorophyllin at least one, all in skin surface noresidue, object is the identification of being convenient to no dipping.

Embodiment 1

Described in the present embodiment, the component of milk cow nipple medicated bath liquid and preparation method are as follows:

1 component and proportioning:

62.5 parts of purified water

4.5 parts, olive oil

1.0 parts of sodium lactates

1.0 parts of HPGs

0.2 part of water soluble chitosan

PHMB0.5 part

30 parts of 1,3-PDs

0.24 part of APG

0.06 part of light green pigment

2 composition explanations:

In the present invention, emollient is that olive oil and sodium lactate combine, and the additional proportion of olive oil and sodium lactate is 9:2.

Although olive oil is the conventional material of skin conditioner in the present invention, be rich in unrighted acid, phenols polyphenoilsAnd various vitamins etc., be easily absorbed by the skin, can increase gloss and the elasticity of skin, can prevent chapped skin. But oftenNeed to carry out water miscible processing, therefore needing to add surfactant could carry out composite with other water miscible skin care materialsUse, also can be in the dip that contains disinfectant stable existence.

In the present invention, sodium lactate, as a kind of NMF (NMF), can dissolve each other with water, alcohols etc., is skin moistureRetention agent, can mix with plant oil skin care material the moisturizing effect of common raising system.

In the present invention, HPG is a kind of derivative of guar gum, can be used as high viscosity liquid, can be effectively steadyDetermine oil-in-water type emulsion system. In the time that adding separately a certain amount of (>=1.2 mass parts), it can keep not dripping, but system nowCan seem very thick, in the medicated bath cup that is difficult to never reflux, extrude and affect practicality.

Water soluble chitosan in the present invention is chitin (chitin) the process deacetylation extensively being existed by natureObtain, chemical name is Chitosan (1-4)-2-amino-B-D glucose, can be used as adhesive, thickener, stabilizing agent,Can form transparent protective layer, skin is had to better affinity interaction, meanwhile, add a certain amount of water soluble chitosan to have collaborativeAntibacterial effect.

The present invention needs one to have low denseness concurrently and full-bodied compound mobility stabiliser system is optimized dipViscosity, thereby improve the practicality of dip. When mobility stabilizing agent total amount is 1.2 mass parts, HPG withWhen water soluble chitosan compound proportion is 5:1, system viscosity is suitable not to drip, and not thick, and in addition, HPG is directBe added to the water and can produce reunion caking phenomenon, be unfavorable for the homogenization effect of system, therefore the present invention adopts 1,3-PD to doFor the decentralized medium of compound mobility stabiliser system solves this problem.

PHMB in the present invention, chemistry hexamethylene by name, colorless and odorless, non-stimulated to skin and mucosaProperty, Mlc is low, and speed of action is fast, and can form for a long time the cationic lasting antibacterial effect of one deck at material surfaceReally, there is not chemical reaction with other components and stable existence in system. Because the guanidine in hexamethyleneBase has higher activity, and polymer becomes electropositive. And virus, each bacterioid is generally elecrtonegativity, so polyhexamethylene guanideSalt is easy to be adsorbed, and then makes the bacterium, virus cannot schizogamy, and loss of activity reaches the object of sterilizing.

In the present invention, PHMB is obviously better than Operand dip as disinfectant, and iodine easily distils and is unstable, and as halogenElement atom, unrighted acid reacts and causes system unstable easily and in vegetable oil.

The effect of 1,3-PD is: the one, contribute to molten in water of HPG and water soluble chitosanSeparate; The 2nd, can effectively reduce the freezing point of dip system, prevent that dip from freezing and destroying system proterties under cryogenic conditions.

APG in the present invention, APG write a Chinese character in simplified form in English, is referred to as again " APG decontamination factor ", is a kind of property of green safetyMore comprehensively new non-ionic surfactants, has high surface, good ecological security and intermiscibility, at thisIn bright, play the effect of solubilising, emulsification, decontamination, the present invention adopts one in APG06, APG0810, APG0814, APG1214 etc.Kind or several, the HLB value of APG is in 10～16 scopes.

Add the identification that pigment contributes to whether dipping, having added many can be in skin deposits, adds to have lacked and can not distinguish and beNo dipping. The present invention adopts light green pigment, is a kind of combined food level pigment, stable under the solubilization of surfactantExist, bright-colored, be convenient to identification.

3 preparation methods:

(1) preparation of disinfectant premixed liquid:

The PHMB of 0.5 mass parts is joined in 10 mass parts purified water and is uniformly mixed;

(2) preparation of mobility stabilizing agent dispersion liquid:

1.0 mass parts HPGs, 0.2 mass parts water soluble chitosan are mixed with the 1,3-PD of 25 mass parts,Stir and obtain dispersion liquid;

(3) preparation of emollient emulsion:

After 4.5 mass parts olive oil, 1.0 mass parts sodium lactates and 5 mass parts 1,3-PDs are mixed, then join 12.5 matterIn the water of amount part, grind 15min homogenizing through colloid mill and obtain emollient emulsion;

(4) homogenize:

By (1) disinfectant premixed liquid, (2) dispersion liquid, (3) emulsion, 0.24 mass parts APG, 0.06 mass parts fruit greenElement joins in 40 mass parts purified water successively, after stirring at ambient temperature, after colloid mill grinds 30min, squeezes intoPlastic Drum, and continue to stir after 2h, leave standstill 2h, obtain a kind of Novel milk cow teats dip finished product of transparent green.

Embodiment 2

Described in the present embodiment, the component of milk cow nipple medicated bath liquid and preparation method are as follows:

1 component and proportioning:

72.5 parts of purified water

4.5 parts, olive oil

1.0 parts of trehaloses

0.84 part of HPG

0.24 part of propylene glycol alginate

0.12 part of chitosan hydrochloride

PHMB0.3 part

0.15 part of gluconic acid chlorhexidine

10.0 parts of 1,2-PDs

10.0 parts of sorbierites

0.3 part of compound detergent

0.05 part of light blue pigment

2 composition explanations:

In the present invention trehalose be by two glucose molecules with a, a, 1,1-glycosidic bond form nonreducing sugar, can be used as foodAntistaling agent, usually at cosmetic field as skin conditioning agent. But its aqueous solution has certain viscosity, this stickum hasGood water retentivity, so generally can not use in the system of destroying its viscosity structure especially oxidisability systemIn, or in the system of high viscosity and wrap up it and can not play a role, therefore need to react without any with olive oil, carry out first multipleAfter joining emulsification, can join in dip system, improve the absorption of skin to trehalose and reach the order of repairing damage skin.

In the present invention, propylene glycol alginate is white or pale yellow powder, is basic by the alginic acid extracting in natural seaweedMaterial modification forms, and its aqueous solution becomes transparent thick colloid, because have lipophile and hydrophily two in its molecular structure simultaneouslyPlanting group, can be used as emulsifying agent, thickener and stabilizing agent, is a kind of common additive that improves food mouthfeel. But alginic acidPropylene glycol ester thickening effect (>=1.2 mass parts) under on an equal basis in addition measuring is not so good as HPG, on the contrary but its viscosity performance.

Chitosan hydrochloride of the present invention is a kind of chitosan derivatives with strong cation, the amorphous powder of whiteEnd, tasteless, nontoxic. The aqueous solution is faintly acid, clear, stable in properties. Because kept the quality of shitosan, so can doFor thickener improves the stability of dip system, but cannot add separately, need to carry out composite with other material.

The present invention adopts compound rheological property stabilizing agent, comprises three kinds of materials, i.e. HPG, propylene glycol alginateAnd chitosan hydrochloride. When additional proportion is HPG: propylene glycol alginate: when chitosan hydrochloride=7:2:1, bodyViscosity and the denseness of system have reached stationary value, extrude, and form at skin surface after dipping in the medicated bath cup that is easy to never reflux, there is thixotroping phenomenon and improved the practicality of dip of the present invention in moistening protective layer and keep not dripping.

In the present invention, compound guanidine class disinfectant is two kinds of Fungicidal substances, i.e. PHMB and gluconic acid chlorhexidine, sterilization effectFruit is better than one matter, and consumption is few, and gluconic acid chlorhexidine is also a kind of guanidine class disinfectant, soluble in water, lives without surfaceProperty agent improve water-solublely, can suppress most of Gram-negative bacteria and gram-positive bacteria, to skin and mucosa nonirritant, press downBacteria concentration is low, and speed of action is fast, better with PHMB compatibility.

Sorbierite in the present invention, white crystalline powder, odorless, has refrigerant sweet taste, can be miscible with water, propane diols. SorbieritePolyhydroxy structure make it have the character of being combined with water, there is hierarchy of control viscosity, keep the effect such as humidity. 1,2-the third twoThe moistening effect of the composite strengthening system of alcohol and sorbierite increases the dissolubility of mobility stabilizing agent in system simultaneously.

The present invention adopts APG0810 and AEO-7 as compound detergent, all belongs to non-ionic surface active agent. AEO-7 isA kind of AEO, good with the composite synergisticing performance of APG0810, there is good wetting power, detergency, biology can fallSolution is good, and APG0810 and AEO-7 adding proportion are 2:1.

The present invention adopts light blue pigment, is a kind of Natural Food grade pigment, stable under the solubilization of surfactantExist, bright-colored, be convenient to identification.

3 preparation methods:

(1) preparation of disinfectant premixed liquid:

The PHMB of 0.3 mass parts and 0.15 mass parts gluconic acid chlorhexidine are joined in 10 mass parts purified water and be uniformly mixedEvenly;

(2) preparation of mobility stabilizing agent dispersion liquid:

By 0.84 mass parts HPG, 0.24 mass parts propylene glycol alginate, 0.12 mass parts chitosan hydrochloride and 5The sorbierite of the 1,2-PD of mass parts and 10 mass parts mixes, and stirs and obtains dispersion liquid;

(3) preparation of emollient emulsion

After 4.5 mass parts olive oil, 1.0 mass parts trehaloses are mixed with 5 mass parts 1,2-PDs, then joinIn the water of 12.5 mass parts, grind 15min homogenizing through colloid mill and obtain emollient emulsion;

(4) homogenize:

By (1) disinfectant premixed liquid, (2) dispersion liquid, (3) emulsion, the compound detergent of 0.3 mass parts, 0.05 mass parts light bluePigment joins in 50 mass parts purified water successively, after stirring at ambient temperature, after colloid mill grinds 30min, beatsEnter Plastic Drum, and continue to stir after 2h, leave standstill 2h, obtain a kind of Novel milk cow teats dip finished product of transparent blue.

Embodiment 3

The Main Pathogenic Bacteria of mastitis for milk cows comprises Escherichia coli, staphylococcus aureus etc., and the present invention is by the embodiment of the present invention 1Carry out anti-(pressing down) the bacterium product bacteriostasis property test of stripping property experimental test with the 2 dip mechanism for testing that prepare, pressed downBacterium result is as shown in table 1.

Table 1

Illustrate that dip of the present invention has excellent bacteriostasis to Escherichia coli, staphylococcus aureus.

Embodiment 4

Skin surface moisture value is important indicator of emollient effect of investigating milk cow nipple medicated bath liquid and relevant skin conditioner, canTest by moisture of skin analyzer. Moisture of skin tester mainly adopts capacitance principle, according to water and other materialsThe difference of dielectric constant is carried out the mensuration of moisture content of skin.

Test condition: 20 ± 2 DEG C of indoor temperatures, humidity 50 ~ 60%.

Test position: the back of the hand tiger's jaw position, area size 3 × 3 ㎝ 2 are substantially constant to moisture value through clear water wiped clean.

Criterion: skin is drier, moisture value is less than 35%; Dry skin, moisture value 35 ~ 50%; Moisture of skin abundance,Moisture value is greater than 50%.

Testing procedure: its moisture value is tested at the tested position after cleaning before smearing; Specifying tested region, smear testedAfter sample (use amount: 0.2g), start timing, at set intervals by vertical probe of tester tested skin surface, 1 of being pressed inIn second, on main frame, just demonstrate the numerical value of moisture of skin. The complete sample of every survey, wipes clean, and treats skin nature rest and reorganization 1h, sideCan carry out the test of next sample. Parallel three times, average, Related product and dip of the present invention are surveyed on the marketExamination, as shown in Figure 1, as seen from the figure, under the dip same time that the present invention prepares, its moistening effect is far above existing for resultThere is product.

The main component of Related product on the market:

1 glycerine water solution: glycerine (20%), water;

Dip before 2 Operands: Iodophor, glycerine, water;

Dip before 3 non-Operands: chlorohexidene or bromogeramine, alcohol, glycerine, water;

4 Operand film forming dips: macromolecule film former, Iodophor, alcohol, glycerine, water etc.;

5 non-Operand film forming dips: chlorohexidene, film forming agent, alcohol, glycerine, water etc.

Embodiment 5

Dip of the present invention adopts food stage and pharmaceutical grade raw material to be prepared from, and excitant and anaphylaxis are to investigate dip to skinSkin has the important indicator having no side effect. At ambient temperature, smear respectively by the dip of embodiment 1,2 preparations in healthy peopleLeft and right the back of the hand tiger's jaw position, after action time 1h, wipes dip with health nonwoven and observes skin, and smears front comparison, knotFruit is without any excitant and allergic reaction.

Embodiment 6

Dip of the present invention is different from the rear dipping product on market, after dipping, can form a kind of moistening protection at skin surfaceLayer, and keep not dripping, can avoid like this waste of dip, effectively reduce livestock farm management cost, accumulation drippage number is inspectionAn index directly perceived of dip mobility is also to judge that mobility stabilizer type and consumption are to dip system mobility shadowRing size,, under the condition of 20 ± 2 DEG C of indoor temperatures, humidity 50～60%, dip length at the nipple of healthy cow and be 5 ±After the rear dip sample that 0.5cm, quality are 3 ± 0.2g, start timing, observe and add up drippage number, each sample does three timesParallel test, averages, and accumulation drippage number statistics is in table 2.

Table 2

The main component of other dip product on market:

1 Operand film forming dip: macromolecule film former, Iodophor, alcohol, glycerine, water etc.;

2 non-Operand film forming dips: chlorohexidene or bromogeramine, film forming agent, alcohol, glycerine, water etc.

Because the mastitis for milk cows incidence of disease is having squeezed after milk in this before nipple closure 30 minutes the highest time, table2 explanation dip of the present invention has good not drippage property with respect to existing product.

Above content is the further description of the present invention being done in conjunction with concrete embodiment, can not assert thisBright concrete enforcement is confined to these explanations. For general technical staff of the technical field of the invention, not de-Under the prerequisite of the present invention's design, can also make some simple deduction or replace, all should be considered as belonging to protection of the present inventionScope.

Claims (10)

1. a Novel milk cow teats dip, is characterized in that being made up of the material of following mass parts:

Purified water 60-88 part;

Emollient 4-6 part;

Mobility stabilizing agent 0.8-1.2 part;

Guanidine class disinfectant 0.2-0.4 part;

Alcohols 4-32 part;

Detergent 0.1-0.4 part;

Described emollient is made up of vegetable oil and natural moisturizing factor, and the mass ratio of described vegetable oil and NMF is 9:2～6:5, olive oil, linseed oil that described vegetable oil is natural extraction, in Jojoba Oil, shea butter, at least one, described daySo the damping factor is at least one in sodium lactate, amino acid, aliphatic acid, trehalose.

2. Novel milk cow teats dip as claimed in claim 1, is characterized in that: described mobility stabilizing agent is by melon thatOne in collagen powder, cation guar gum, HPG and water soluble chitosan, chitosan derivatives, alginic acid the third two5:1～7:5 is composite in mass ratio forms at least one in alcohol ester, bassora gum, lauric acid amide of ethanol.

3. Novel milk cow teats dip as claimed in claim 2, is characterized in that: described chitosan derivatives is shitosanAt least one in hydrochloride, hydroxypropyl chitosan, hydroxyethyl chitosan, CMC.

4. Novel milk cow teats dip as claimed in claim 1, is characterized in that: described guanidine class disinfectant is cation formSurface-active agent.

5. Novel milk cow teats dip as claimed in claim 4, is characterized in that: described cationic surfactant is vinegarAcid chlorhexidine, gluconic acid chlorhexidine, hexamethylene (PHMB), polyhexamethylene list guanidine hydrochloride(PHMG), at least one in polyaminopropyl biguanide (PAPB), few [2-(2-ethyoxyl)-ethoxy ethyl ester] chlorination guanidine.

6. Novel milk cow teats dip as claimed in claim 1, is characterized in that: described alcohol is 1,3-PD, 1,2-At least one in propane diols, polyethylene glycol, butanediol, glycerine, polypropylene glycol, sorbierite.

7. Novel milk cow teats dip as claimed in claim 1, is characterized in that: the HLB value of described detergent is 8～16In scope.

8. Novel milk cow teats dip as claimed in claim 7, is characterized in that: described detergent is polysorbate, alkaneIn base glucose amide, alkylolamides, APG (APG), AEO at least one.

9. Novel milk cow teats dip as claimed in claim 1, is characterized in that: also comprise pigment, its mass parts is0.05-0.06 part, described pigment is at least one in fruit green, egg yolk, sunset yellow, light blue.

10. a preparation method for Novel milk cow teats dip described in claim 1-9, is characterized in that comprising following stepRapid:

(1) preparation of disinfectant premixed liquid: guanidine class disinfectant is joined in 10-13 mass parts purified water and is uniformly mixed;

(2) preparation of mobility stabilizing agent dispersion liquid: mobility stabilizing agent is mixed with 3-26 mass parts alcohols, stirObtain dispersion liquid;

(3) preparation of emollient emulsion: after emollient and 1-6 mass parts alcohols are mixed, then join 10-13 mass partsWater in, grind 15min homogenizing through colloid mill and obtain emollient emulsion;

(4) homogenize: the disinfectant premixed liquid that step (1) is obtained, dispersion liquid, the step (3) that step (2) obtains obtainEmulsion, detergent, pigment join in 40-62 mass parts purified water, after stirring at ambient temperature, through colloid successivelyMill grinds after 30min, and continues to stir 2h, leaves standstill 2h, obtains Novel milk cow teats dip.