CN107456461A - Elemental sulfur, iodine mixture and preparation method thereof - Google Patents
Elemental sulfur, iodine mixture and preparation method thereof Download PDFInfo
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- CN107456461A CN107456461A CN201710548555.3A CN201710548555A CN107456461A CN 107456461 A CN107456461 A CN 107456461A CN 201710548555 A CN201710548555 A CN 201710548555A CN 107456461 A CN107456461 A CN 107456461A
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- elemental sulfur
- preparation
- iodine mixture
- auxiliary agent
- pvp
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Abstract
The present invention provides a kind of elemental sulfur, iodine mixture and preparation method thereof.A kind of elemental sulfur, iodine mixture include elemental sulfur, PVP-I and auxiliary agent.Preparation method comprises the following steps：Step 1: raw material tentatively mixes：Part auxiliary agent is mixed；Step 2: raw material mixes again：Elemental sulfur, PVP-I and remaining auxiliary agent are added in the batch mixing of step 1, are well mixed；Step 3: finished product is made.A kind of elemental sulfur provided by the invention, iodine mixture are mainly used in the preventing and treating of mastitis for milk cows.
Description
Technical field
The invention belongs to pharmaceutical production technical field, more particularly to a kind of elemental sulfur, iodine mixture and preparation method thereof.
Background technology
Sulphur is a kind of chemical element, and its chemical symbol is S in the periodic table of elements, and atomic number is 16.It is a kind of non-
That usually sees is tasteless and odorless nonmetallic, and pure sulphur is the crystal of yellow, also known as does sulphur.Sulphur has many different chemical valences,
It common are -2,0 ,+4 ,+6 grades (sulphur aobvious -1 in ferrous disulfide).It is often with the shape of sulfide or sulfate in nature
Formula occurs, and especially also occurs in the pure sulphur in Volcanic Region in nature.For all biologies, sulphur be all it is a kind of it is important must
Indispensable element, it is the part of several amino acids, is thus the part of most protein.It mainly by with
In fertilizer, also it is widely used in gunpowder, lubricant, insecticide and antifungal agent.Iodine medicament, its Main Ingredients and Appearance are iodate
Potassium, when nuclear power plant radiates because of disaster and leaked, allow periphery live in the people take the crystalline flake of iodine can make iodine in thyroid gland saturation reduce first shape
Absorption of the gland to radioactivity iodine -131.But need to be just effective in being taken in 4 hours when by free-iodine radioactive exposure, and nothing
Method prevents free radiation and the isotope beyond iodine -131.Common people take without instruction improper can cause the hyperfunction disease of thyroid gland.
PVP-I has strong bactericidal action, can kill bacterium, gemma, fungi, virus, protozoon etc., and external application effect is good.Existing milk cow's milk
Room inflammation protective agents effect is bad, and pharmacy procedure is complicated, and production cost is high.
The content of the invention
Bad to solve existing mastitis for milk cows protective agents effect, pharmacy procedure is complicated, and the high technology of production cost is asked
Topic, a kind of mastitis for milk cows protective agents effect of present invention offer is good, and pharmacy procedure is easy, the not high elemental sulfur of production cost,
Iodine mixture and preparation method thereof.
Elemental sulfur provided by the invention, iodine mixture include elemental sulfur, PVP-I and auxiliary agent.
In elemental sulfur provided by the invention, a kind of preferred embodiment of iodine mixture, the simple substance sulphur concentration is 5%, described
The concentration of PVP-I is 2%.
In elemental sulfur provided by the invention, a kind of preferred embodiment of iodine mixture, the auxiliary agent includes forming agent, steady
Determine agent and filming agent.
In elemental sulfur provided by the invention, a kind of preferred embodiment of iodine mixture, the auxiliary agent include polyvinyl alcohol,
Glycerine, Tween 80, golden spring essence and edible glue, the concentration of the polyvinyl alcohol is 10%, and the concentration of the edible glue is
0.2%, the glycerol content is 4ml/100ml, and the Tween 80 content is 1ml/100ml, and the golden spring essence content is
1ml/100ml。
In elemental sulfur provided by the invention, a kind of preferred embodiment of iodine mixture, the elemental sulfur is the simple substance of 600 mesh
Sulphur.
Elemental sulfur provided by the invention, the preparation method of iodine mixture, comprise the following steps：
Step 1: raw material tentatively mixes：Part auxiliary agent is mixed；
Step 2: raw material mixes again：Elemental sulfur, PVP-I and remaining auxiliary agent are added to the batch mixing of step 1
In, it is well mixed；
Step 3: finished product is made：It is filling after time text to normal temperature, bubble collapse.
In a kind of preferred embodiment of preparation method of elemental sulfur provided by the invention, iodine mixture, in the step 1, institute
The preliminary blend step of raw material is stated to comprise the following steps：
Step 1 one, prepare polyvinyl alcohol：12 hours in advance, soak polyethylene with 20 milliliters of purified water (being heated to 50 degree)
Alcohol, 70 degree are again heated to, is heated while stirring, quick stirring, prevent from being sticking, to without little particle, be creamy white colloid；
Step 1 two, prepare edible glue：With 50 milliliters of purified water immersion edible glues, then it is sufficiently stirred into equal within 12 hours in advance
Even pasty state；
Step 1 three, raw material mixing：The polyvinyl alcohol of milky colloid is slowly added in the edible glue of pasty state, Bian Jia
Enter side stirring, be allowed to well mixed.
In a kind of preferred embodiment of preparation method of elemental sulfur provided by the invention, iodine mixture, the step 2 is specific
Elemental sulfur, PVP-I, glycerine, Tween 80, essence to be slowly added in the solution in step 1 successively respectively, side adds
Side is stirred, and is allowed to uniform.
Elemental sulfur, the iodine mixture and preparation method thereof of the present invention has the advantages that：
PVP-I has strong bactericidal action, can kill bacterium, gemma, fungi, virus, protozoon etc., and external application effect is good.Sulphur
After being contacted with skin or tissue secretion thing, H2S and pentathionic acid are generated, produces the effect of sterilization (including fungi).Outside animal body
Experiment shows that it is permeated by skin and mammary gland, improves milk cow body sulfhydryl content, can activate and improve macrophage in body
Phagocytosis bacterium function, improve body non-specific immune function, so as to improve the immunologic function of milk cow.It is mainly used in cow breast
Scorching preventing and treating.It is mainly used in treating acute mastitis：Nipple is red and swollen, pain of milking.Four times a day, it is used in conjunction 3-7 days.It is chronic to put material
Mammitis：Breast tissue is swollen hard, and pain of milking, milk is bean curd scoriform.Four times a day, it is used in conjunction 10-20 days.Prevention method：It incite somebody to action this
Product dilute 2-3 times, are stained with bath nipple after milking every time.
Brief description of the drawings
Technical scheme in order to illustrate the embodiments of the present invention more clearly, make required in being described below to embodiment
Accompanying drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for
For those of ordinary skill in the art, on the premise of not paying creative work, it can also be obtained according to these accompanying drawings other
Accompanying drawing, wherein：
Fig. 1 is elemental sulfur provided by the invention, a kind of process chart of embodiment of the preparation method of iodine mixture；
The preliminary blend step of raw material of the step of Fig. 2 is the preparation method of elemental sulfur shown in Fig. 1, iodine mixture one is a kind of real
Apply the process chart of example.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only the part of the embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained all other under the premise of creative work is not made
Embodiment, belong to the scope of protection of the invention.
The elemental sulfur, iodine mixture 1 include elemental sulfur, PVP-I and auxiliary agent.The simple substance sulphur concentration is 5%,
The concentration of the PVP-I is 2%.
The auxiliary agent includes forming agent, stabilizer and filming agent.
The auxiliary agent includes polyvinyl alcohol, glycerine, Tween 80, golden spring essence and edible glue, the polyvinyl alcohol
Concentration is 10%, and the concentration of the edible glue is 0.2%, and the glycerol content is 4ml/100ml, and the Tween 80 content is
1ml/100ml, the golden spring essence content is 1ml/100ml.
The elemental sulfur is the elemental sulfur of 600 mesh.
Referring to Fig. 1, it is elemental sulfur provided by the invention, a kind of technological process of embodiment of the preparation method of iodine mixture
Figure.
Elemental sulfur provided by the invention, the preparation method S1 of iodine mixture, comprise the following steps：
Step S11, raw material tentatively mixes：Part auxiliary agent is mixed；
Step S12, raw material mixes again：Elemental sulfur, PVP-I and remaining auxiliary agent are added to step S11 batch mixing
In, it is well mixed；Elemental sulfur, PVP-I and glycerine, Tween 80, essence are specially slowly added to step S11 successively respectively
In solution in, stir while adding, be allowed to uniform；
Step S13, finished product is made：It is filling after time text to normal temperature, bubble collapse.
The preliminary blend step of raw material of the step of Fig. 2 is the preparation method of elemental sulfur shown in Fig. 1, iodine mixture one is a kind of real
Apply the process chart of example.
The preliminary blend step of raw material comprises the following steps：
Step S111, polyvinyl alcohol is prepared：12 hours in advance, soak polyethylene with 20 milliliters of purified water (being heated to 50 degree)
Alcohol, 70 degree are again heated to, is heated while stirring, quick stirring, prevent from being sticking, to without little particle, be creamy white colloid；
Step S112, edible glue is prepared：With 50 milliliters of purified water immersion edible glues, then it is sufficiently stirred into equal within 12 hours in advance
Even pasty state；
Step S113, raw material mixes：The polyvinyl alcohol of milky colloid is slowly added in the edible glue of pasty state, Bian Jia
Enter side stirring, be allowed to well mixed.
Elemental sulfur, iodine mixture and preparation method thereof the S1 of the present invention has the advantages that：
PVP-I has strong bactericidal action, can kill bacterium, gemma, fungi, virus, protozoon etc., and external application effect is good.Sulphur
After being contacted with skin or tissue secretion thing, H2S and pentathionic acid are generated, produces the effect of sterilization (including fungi).Outside animal body
Experiment shows that it is permeated by skin and mammary gland, improves milk cow body sulfhydryl content, can activate and improve macrophage in body
Phagocytosis bacterium function, improve body non-specific immune function, so as to improve the immunologic function of milk cow.It is mainly used in cow breast
Scorching preventing and treating.It is mainly used in treating acute mastitis：Nipple is red and swollen, pain of milking.Four times a day, it is used in conjunction 3-7 days.It is chronic to put material
Mammitis：Breast tissue is swollen hard, and pain of milking, milk is bean curd scoriform.Four times a day, it is used in conjunction 10-20 days.Prevention method：It incite somebody to action this
Product dilute 2-3 times, are stained with bath nipple after milking every time.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair
The equivalent structure or equivalent flow conversion that bright specification and accompanying drawing content are made, or directly or indirectly it is used in other related skills
Art field, is included within the scope of the present invention.
Claims (8)
1. a kind of elemental sulfur, iodine mixture, it is characterised in that including elemental sulfur, PVP-I and auxiliary agent.
2. the preparation method of elemental sulfur according to claim 1, iodine mixture, it is characterised in that the simple substance sulphur concentration is
5%, the concentration of the PVP-I is 2%.
3. the preparation method of elemental sulfur according to claim 1, iodine mixture, it is characterised in that the auxiliary agent includes
Forming agent, stabilizer and filming agent.
4. the preparation method of elemental sulfur according to claim 1, iodine mixture, it is characterised in that the auxiliary agent includes
Polyvinyl alcohol, glycerine, Tween 80, golden spring essence and edible glue, the concentration of the polyvinyl alcohol are 10%, the edible glue it is dense
Spend for 0.2%, the glycerol content is 4ml/100ml, and the Tween 80 content is 1ml/100ml, the golden spring essence content
For 1ml/100ml.
5. the preparation method of elemental sulfur according to claim 1, iodine mixture, it is characterised in that the elemental sulfur is 600 mesh
Elemental sulfur.
6. elemental sulfur, the preparation method of iodine mixture in a kind of claim 1 to 5 described in any one, it is characterised in that including
Following steps：
Step 1: raw material tentatively mixes：Part auxiliary agent is mixed；
Step 2: raw material mixes again：Elemental sulfur, PVP-I and remaining auxiliary agent are added in the batch mixing of step 1, mixed
Close uniform；
Step 3: finished product is made：It is filling after time text to normal temperature, bubble collapse.
7. the preparation method of elemental sulfur according to claim 6, iodine mixture, it is characterised in that described in the step 1
The preliminary blend step of raw material comprises the following steps：
Step 1 one, prepare polyvinyl alcohol：12 hours in advance, polyvinyl alcohol is soaked with 20 milliliters of purified water (being heated to 50 degree),
70 degree are again heated to, is heated while stirring, quick stirring, prevents from being sticking, to without little particle, be creamy white colloid；
Step 1 two, prepare edible glue：With 50 milliliters of purified water immersion edible glues, then uniformly paste is sufficiently stirred within 12 hours in advance
Shape；
Step 1 three, raw material mixing：The polyvinyl alcohol of milky colloid is slowly added in the edible glue of pasty state, when adding
Stirring, is allowed to well mixed.
8. the preparation method of elemental sulfur according to claim 7, iodine mixture, it is characterised in that the step 2 specifically,
Elemental sulfur, PVP-I, glycerine, Tween 80, essence are slowly added in the solution in step 1 successively respectively, stirred when adding
Mix, be allowed to uniform.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710548555.3A CN107456461A (en) | 2017-07-06 | 2017-07-06 | Elemental sulfur, iodine mixture and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710548555.3A CN107456461A (en) | 2017-07-06 | 2017-07-06 | Elemental sulfur, iodine mixture and preparation method thereof |
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| CN107456461A true CN107456461A (en) | 2017-12-12 |
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ID=60546068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201710548555.3A Pending CN107456461A (en) | 2017-07-06 | 2017-07-06 | Elemental sulfur, iodine mixture and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113274405A (en) * | 2021-04-23 | 2021-08-20 | 内蒙古新开元动物药业发展有限公司 | Preparation method of compound preparation for treating cow foot rot and mastitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106177A (en) * | 2015-07-31 | 2015-12-02 | 河南牧业经济学院 | Film-forming agent capable of preventing cow mastitis and preparation method thereof |
-
2017
- 2017-07-06 CN CN201710548555.3A patent/CN107456461A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106177A (en) * | 2015-07-31 | 2015-12-02 | 河南牧业经济学院 | Film-forming agent capable of preventing cow mastitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中国兽药典委员会: "《中华人民共和国兽药典兽药使用指南 2005年版 化学药品卷》", 30 April 2006, 中国农业出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113274405A (en) * | 2021-04-23 | 2021-08-20 | 内蒙古新开元动物药业发展有限公司 | Preparation method of compound preparation for treating cow foot rot and mastitis |
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Application publication date: 20171212 |