CN112635079A - Technical research of povidone iodine film-forming infusion for medicated bath of nipples for preventing mastitis of dairy cows - Google Patents

Abstract

The invention relates to the field of prevention of mastitis of dairy cows, and discloses a technical research of a povidone iodine film-forming infusion for medicated bath of nipples of the dairy cows for preventing mastitis. The technical research of the povidone iodine film-forming infusion for the medicated bath on the nipples of the dairy cows for preventing mastitis is characterized in that raw and auxiliary materials which are safe, non-toxic, efficient and low in irritation are selected, povidone iodine, glycerin, potassium iodide, gelatin, tween-80 and the like are used as main raw materials, the research of the formula proportion is carried out, technological parameters such as temperature, PH, feeding modes, mixing time and the like are adjusted, the instant film-forming is carried out after the medicated bath on the nipples of the dairy cows, a layer of protective film is formed, the sterilization effect is effectively guaranteed, no irritation and high comfort are caused to the nipples of the dairy cows, the cow does not have discomfort, and the medicated bath film is easy to clean and free of residues, is safe to people and livestock, and.

Description

Technical research of povidone iodine film-forming infusion for medicated bath of nipples for preventing mastitis of dairy cows

Technical Field

The invention relates to the field of prevention of mastitis of dairy cows, in particular to a technical research of a povidone iodine film-forming infusion for medicated bath of nipples for preventing mastitis of dairy cows.

Background

The mastitis of the dairy cow is mastitis of the dairy cow caused by mechanical, physical, chemical and biological effects, is one of the most serious diseases causing the greatest harm to dairy cow farms and the loss of dairy cows, about 2.5 hundred million dairy cows exist all over the world at present, about 38 percent of the dairy cows suffer from various types of mastitis, the property loss caused to the mass dairy cow breeding industry is huge, the loss of over 170 million pounds is statistically caused in the United kingdom every year, the loss of 20 million dollars is caused in the United states every year, the incidence rate of the mastitis of the dairy cow in China is higher and is about 20 to 70 percent, the incidence rate of recessive mastitis accounts for 70 percent, the loss caused by the mastitis of the dairy cow in China reaches 1.35 million RMB every year, after the mastitis of the affected dairy cow is treated, the milk yield, the milk quality and the nutritional value are reduced, and the utilization period of the dairy cow is seriously influenced.

However, in the conventional medicated bath for preventing mastitis of cow nipples, since a lot of alcohol is used, for the cow nipples requiring a long-term repeated use of disinfectant, the alcohol has strong hydrophilicity, not only can deprive the skin of water, but also can dissolve out fat-soluble components in the skin, so that fine lines and wrinkles appear on the skin, after the skin is repeatedly contacted for a long time, the phenomena of dryness and chapping can occur, the skin of the nipples can be damaged after the skin is repeatedly contacted for a long time, a film cannot be rapidly formed after the skin is contacted with the cow nipples, grass, soil and the like are easily adhered, the curative effect is influenced, the sanitation problem is caused, a large amount of liquid is dripped after the skin is contacted with the cow nipples, a large amount of waste is caused, and the product cost is indirectly increased.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the technical research of the povidone iodine film-forming infusion for medicated bath of the nipples of the dairy cows for preventing the mastitis of the nipples, has the advantages of no irritation to the nipples of the dairy cows, rapid film formation after the nipple of the dairy cows is contacted, no dripping of liquid, wide sterilization spectrum, no toxic or side effect on people and livestock, no residue and the like, and solves the problems provided by the background technology.

(II) technical scheme

In order to realize the purposes of no irritation to the nipples of the milk cows, quick film formation after the nipples of the milk cows are contacted, no liquid dripping, wide sterilization spectrum, no toxic or side effect on people and livestock, no residue and the like, the invention provides the following technical scheme: a povidone iodine film-forming infusion for the medicated bath of mammitis nipple of milk cow is prepared through cleaning main body, arranging the main body in clean mode, no leakage, no overflow, no drip, no leakage, no oil dirt, no sewage, no oil dirt and impurities, regular inspection, maintenance and maintenance according to the rule of operation and maintenance, cleaning tools, storing in a specific place or tool frame, arranging in order, storing by special person, cleaning containers and utensils, and cleaning containers.

Preferably, the doors must be closed during operation to minimize access times, unnecessary items are not allowed to be brought into the production area, the doors have exhaust and dust removal devices, and the doors have cleaning regulations, and have sufficient time for cleaning, cleaning and disinfection every day or during product change, and the doors have health status marks in production workshops or production lines, equipment machines and containers.

Preferably, the logistics procedure is that the raw materials are subpackaged and then finished products are obtained, the logistics procedure is that the articles are outsourced and then are sent to the production area, and the cleaning procedure is that people put shoes, remove coats, wash hands, wear work clothes and work areas.

Preferably, the weighing is carried out, whether tools used by a platform scale, a counter scale and the like are clean is carefully checked before weighing, materials are received from a warehouse according to production instructions, whether the names, specifications, batch numbers, quantities and the like of the products conform to the production instructions is carefully checked when the tools are received, povidone iodine and auxiliary materials are weighed according to the production instructions and a material demand sheet, the rest materials are bound and sealed, a filling return sheet is returned to a warehouse keeper, the weighed materials are filled in a material mixing label and handed over to a subpackaging process, original records are filled in time, and a variety is weighed and then is cleared and recorded according to a clear yard management system.

Preferably, after weighing, preparing and opening a door of a liquid preparation tank, adding 50% of purified water according to the prescription amount, heating and stirring, adding all auxiliary materials until the auxiliary materials are dissolved, keeping stirring, adding povidone iodine, dissolving, adding the purified water to a specified amount, sampling 50ml, and performing content and property detection and inspection to obtain qualified product, starting a liquid pump to enable the liquid medicine to pass through a precision filter to the liquid storage tank, and performing sampling detection to obtain the qualified product and then notifying filling.

Preferably, after preparation, filling is carried out, direct bottling is carried out according to specification requirements, inspection is carried out before operation, whether sundries irrelevant to production exist on a working table surface or not is checked, whether a power supply meets requirements or not, whether an electromagnetic induction sealing machine is normal or not, whether equipment is grounded or insulated well or not and whether motor steering is normal or not are checked, the filled medicine bottles are sealed by the electromagnetic induction sealing machine, and then a transfer list transfer packaging procedure is filled.

Preferably, after filling, the packaging box is inspected, plastic bottles are labeled, finished products are sampled and reserved, the packaging box is filled, 15 bottles in each box are labeled with one certificate, box labels are respectively labeled on the left and the right of the packaging box, the box is sealed by using an adhesive tape, the inspection is carried out, the finished product samples are inspected according to quality standards, and the temporary storage procedures of finished products to be inspected are carried out in a finished product warehouse to be inspected.

(III) advantageous effects

Compared with the prior art, the invention has the following beneficial effects:

1. the technical research of the povidone iodine film-forming infusion for medicated bath of nipples and nipples in dairy cows is to select safe, nontoxic, efficient and low-irritation raw and auxiliary materials, and to research the formula proportion by using povidone iodine, glycerin, potassium iodide, gelatin, tween-80 and the like as main raw materials so as to achieve the stability and applicability of the product.

2. According to the technical research of the povidone iodine film-forming infusion for the medicated bath of the nipples and the nipples of the dairy cows, a domestic leading process is adopted, the optimal production scheme is selected by adjusting process parameters such as temperature, PH, feeding mode, mixing time and the like, a set of mature production and processing process is developed, a film is rapidly formed within 5min after the medicated bath of the nipples of the dairy cows, a layer of protective film is formed, the sterilization effect is effectively guaranteed, and invasion of bacteria, weeds and dust is isolated.

3. The technical research of the povidone iodine film-forming infusion for medicated bath on the nipples of the dairy cows for preventing mastitis of the nipples does not drip after medicated bath, effectively ensures high-efficiency utilization of products, reduces the medication cost, has no stimulation to the nipples of the dairy cows, has high comfort level and no discomfort for the dairy cows, and the medicated bath film is easy to clean and residue-free, is safe to people and livestock, and ensures the safety of food.

Drawings

FIG. 1 is a schematic view of the process flow structure of the present invention;

FIG. 2 is a schematic diagram of the quality control essential point of the present invention;

FIG. 3 is a schematic illustration of the inventor's static standard;

FIG. 4 is a schematic diagram of the working standard of the present invention;

FIG. 5 is a schematic diagram of the consumption rate of raw and auxiliary materials according to the present invention;

FIG. 6 is a schematic view of the packaging material consumption rating of the present invention;

FIG. 7 is a schematic view of a model of the production apparatus of the present invention;

FIG. 8 is a schematic diagram of the labor organization and post setter of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.

Referring to fig. 1-8, the invention provides a technical scheme of a medicinal bath povidone iodine film-forming infusion for preventing mastitis of dairy cows, which is characterized in that whether tools used by a platform scale, a counter scale and the like are clean is carefully checked before weighing, materials are fetched from a warehouse according to production instructions, whether the names, specifications, batch numbers, quantities and the like of the products are in accordance with the production instructions is strictly checked when the materials are fetched, povidone iodine and auxiliary materials are weighed according to the production instructions and a material demand sheet, the rest materials are bound and sealed, the filling return sheet is returned to a warehouse keeper, the weighed materials are filled in an ingredient label and transferred to a subpackaging procedure, a variety is weighed in time and then is cleared and recorded according to a clear yard management system, a door of a dispensing tank is opened during preparing, purified water with the amount of 50 percent of the prescription is added, heating and stirring are carried out, all the auxiliary materials are added until being dissolved, stirring is kept, adding povidone iodine, dissolving, adding purified water to a specified amount, sampling 50ml for content and character detection, testing to be qualified, starting a liquid pump, enabling the liquid medicine to pass through a precision filter to a liquid storage tank, sampling and detecting, informing the filling when the liquid medicine is qualified, directly bottling the filled liquid medicine according to specification requirements, and checking before operation: checking whether the working table has sundries irrelevant to production; whether the inspection power meets the requirements or not, whether the electromagnetic induction sealing machine is normal or not, whether equipment grounding and insulation are good or not, whether motor steering is normal or not, after the medicine bottle which is filled is sealed by the electromagnetic induction sealing machine, a hand-over and packaging process is filled in a hand-over bill, the hand-over and packaging process is carried out according to the 'stock clearing management system', a record is made, the finished product of the plastic bottle label is sampled and reserved for packaging, 15 bottles are pasted with one qualification certificate for each box during packaging, box labels are pasted with one box label on the left and right of the packaging box, the box is sealed by an adhesive tape, the finished product is inspected according to quality standards during inspection, the temporary storage process is carried out in a finished product warehouse to be inspected, and quality.

According to the requirements of 'veterinary drug production quality management standards', the roofs and walls of the factory buildings are covered with waterproof paint by adopting a brick-concrete structure, are flat and smooth, have no gaps, do not fall off, do not emit or adsorb dust particles, and can resist cleaning and disinfection; the transmission pipeline, the water, the electricity and the process pipeline are concealed, the factory can prevent the entry of animals such as insects, birds, rats and the like, a door must be closed during the work, the number of times of entry and exit is reduced as much as possible, unnecessary articles are not allowed to be brought into a production area, an air exhaust and dust removal device is provided, a matched cleaning regulation is provided, enough time is provided for cleaning, cleaning and disinfection every day or during the variety replacement, equipment machines and containers are all provided with a sanitary state mark in a production workshop or a production line, the sanitation requirements and the disinfection of the equipment tools (including transportation tools) and the containers are realized, an equipment main body is cleaned, tidied, prevented from running, emitting, dripping and leaking, the axial light is realized, a ditch is seen at the bottom, the equipment is seen at the natural color, no oil dirt, no sewage, no oil stain and no sundries are realized around the equipment, the regular inspection, maintenance and regular maintenance and maintenance are carried out according to, the container is orderly stacked, is kept by a specially-assigned person, various instruments and containers used in the production are required to be cleaned, foreign matters and residues cannot be left on the surfaces of the instruments and containers, mildew and microbial contamination cannot be prevented in a humid and high-temperature area, mildew stains and fungus clusters cannot be caused, the containers are cleaned immediately after use, and residues of cleaning agents and disinfectants cannot be caused to prevent the pollution to medicines.

Operators are healthy, stay on duty with health certification, check up once every year, once the operators have infectious diseases, recessive infectious diseases, mental diseases, traumatic wounds, skin diseases, allergy and other symptoms, the operators can never continue to work with direct contact with medicines or related works, before going on duty every day, the operators need to wear clean and intact work clothes, work shoes, wear masks, and do not allow makeup, the operators are coated with powdery skin care products, and do not allow dresses, watches and communication equipment, the work clothes are cleaned and disinfected by a washing machine according to cleaning rules, and wash 2 times a week, operating personnel can not wear the work clothes birth area, pay attention to personal hygiene at any time, wash once every two days at least, wash 1-2 times every week, do not fall dandruff, the hair is cut on duty, shave, cut the nail on duty, change underwear on duty, other should accord with GMP production requirement, logistics procedure: raw material → split charging → finished product (unidirectional forward flow, no reciprocating motion), material purification procedure: article → outsourcing → production area, human clean procedure: people → more shoes → out of coat → washing hands → wearing work clothes → work area, people's clean standard refers to figure 3, work standard refers to figure 4, purified water quality standard, purified water should accord with national purified water quality standard.

Raw and auxiliary material consumption quota, with reference to fig. 5, theoretical yield: 250 barrels, yield: 95% -100%, material balance calculation formula: (actual product quantity + tailings + sample volume) ÷ theoretical quantity = yield, packaging material consumption quota, see fig. 6, packaging material loss rate: carton: 0.3%, 20kg bucket: 0.5%, label: 1.5%, the model of the production equipment refers to fig. 7.

Technical safety is equipped with the emergency exit on the passageway, and factory building, workshop are equipped with fire-fighting equipment, and the management of professional is established to the firer, is equipped with the fire fighter of working concurrently, and inflammable goods professional management, the safe power consumption, all electrical apparatus shells all adopt ground protection, for preventing emergency power failure and other affairs, emergency lighting equipment should be installed in the production area, removes 36V low-tension electricity for the electric light to take protection casing, mechanical safety measure: the main position that rotates of mechanical motor, device safety protecting cover, inspection machinery position refuels unblocked back before each process is thrown the material, and the normal side of taking a trial run can be used, and abnormal conditions must not operate, the outfit of work protection work articles for use: the method is characterized in that necessary personal labor protection articles such as specified work clothes, work hats, work shoes, masks, gloves and the like are prepared, and labor protection facilities are as follows: the post that produces dust and smell sets up dust remover or exhaust device, accords with GMP regulation requirement, and work organization, post graduator refer to figure 8, and the working hour quota calculates the formula: process man-hour quota = process labor time ÷ unit qualified product yield, product production cycle: 1 day, a batch of 250 barrels for one production cycle.

Calculating technical and economic indexes, and obtaining the finished product rate: actual yield/theoretical yield × 100%, and the verification index: the yield of the finished product is more than or equal to 99 percent, and the material balance calculation formula is as follows:

packing theoretical yield: 99.0% -100%

The packing yield is (number of warehouses + number of samples left)/(number of warehouses + number of samples left + number of losses left) × 100%

Theoretical yield of the finished product: 95.0 to 100.0 percent

The yield of finished products is (number of warehouses plus reserved samples)/theoretical number multiplied by 100 percent

And (3) label balance calculation: (usage amount + scrappage amount + remaining amount)/receiving amount multiplied by 100%

The industrial wastewater is discharged after reaching the standard through treatment, dust in the production process has a trapping measure, and no waste gas or waste residue is polluted.

Meanwhile, the feeding of the dairy cows is strictly carried out according to the feeding standard of the dairy cows, the fine and coarse feeds are reasonably matched, the requirements of the feeds are diversified, the nutrition uniformity of the dairy cows is ensured, the physique is strong, the immunity is enhanced, sufficient clean drinking water is ensured, the feeding of the frozen or mildewed forage grass feed is forbidden, the design of the cattle shed is ensured to be warm in winter and cool in summer, the ventilation is good, various equipment and facilities are complete, sufficient, clean, soft and dry padding is laid on the cattle bed and can be exchanged timely, the occurrence of mastitis caused by frostbite or damage to breasts is avoided, the flat, dry and waterlogging and excrement squeezing of the sports ground are maintained, the cattle body is frequently brushed, the health of the cattle body is maintained, the cattle shed and the sports ground are thoroughly cleaned and disinfected regularly, a large number of germs can be eliminated, the occurrence of the mastitis is greatly reduced, the clean and dirty channels of the operation channels of the, strictly executing isolation measures, feeding the cows with mastitis in an isolation shed, independently feeding, independently milking, preventing cross infection, treating in time, transferring the cows to a healthy herd after the sick cows are completely recovered, eliminating the sick cows which are not cured for a long time, observing the breasts of the cows when milking every day, finding that the breasts are red, swollen, hot and painful or have clear milk and flocculent phenomena, checking in time, performing isolation treatment in time, thoroughly cleaning and drying the breasts before milking, massaging the breasts, manually squeezing heads to discard the milk, mounting cups to start milking, removing the cups when the milk stops flowing out, preventing mastitis from occurring due to excessive milking, performing medicated bath on the teats after milking to prevent bacterial infection, periodically overhauling and maintaining the milking machines, and keeping the milking machines in normal running state all the time, if the milking device is improperly used, breast tissue damage can be caused, the risk of mastitis occurrence is increased, the dry milk period is the best period for preventing and treating the mastitis, antibiotics are injected into the breasts after the dry milk, and the milk in the breasts is squeezed completely if the breasts are found to have red, swollen, hot and painful conditions, and the bacterial infection can be reduced after the antibiotics are injected into the breasts.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (7)

1. A technical research of a povidone iodine film-forming infusion for medicated bath of nipples for preventing mastitis of dairy cows is characterized in that: the main body of the equipment is clean, neat, free from running, overflowing, dripping and leaking, the main body of the equipment can see the light on the axis, the ditch can see the bottom, the equipment can see the natural color, the periphery of the equipment can see no oil dirt, sewage, oil stain and sundries, the equipment can be regularly checked, maintained and maintained according to the specified equipment operation and maintenance rules, tools can be cleaned, the equipment can be stored in a specified place or a tool frame in order, the equipment can be stored by a special person, various instruments and containers used in the production can be cleaned, foreign matters and remnants cannot be left on the surface, the damp and high-temperature areas can be prevented from mildewing and microbial contamination, the containers can be immediately cleaned after being used, and residues of cleaning agents and disinfectants cannot be left, so that the pollution to medicines can be prevented.

2. The technical research of the povidone-iodine film-forming infusion for medicated bath of nipples and preventing mastitis in dairy cows according to claim 1 is characterized in that: the door must be closed during the operation, reduces the number of times of coming in and going out as much as possible, unnecessary articles are not allowed to be brought into the production area, the door is provided with an air exhaust and dust removal device and a matched cleaning rule, enough time is provided for cleaning, cleaning and disinfecting every day or when the variety is changed, and the door is provided with a sanitary state mark in a production workshop or a production line, equipment machinery and a container.

3. The technical research of the povidone-iodine film-forming infusion for medicated bath of nipples and preventing mastitis in dairy cows according to claim 1 is characterized in that: the logistics procedure is that the raw materials are subpackaged and then finished products are obtained, the material cleaning procedure is that the articles are taken out of the bag and then are taken into the production area, and the cleaning procedure is that the people put shoes, take off coats, wash hands, wear work clothes and work areas.

4. The technical research of the povidone-iodine film-forming infusion for medicated bath of nipples and preventing mastitis in dairy cows according to claim 1 is characterized in that: the method comprises the steps of weighing, carefully checking whether tools used by a platform scale, a counter scale and the like are clean or not before weighing, picking up materials in a warehouse according to production instructions, carefully checking whether the name, specification, batch number, quantity and the like of the products conform to the production instructions or not when the tools are picked up, weighing povidone iodine and auxiliary materials according to the production instructions and a required material list, binding and sealing the residual materials, returning the filling list to a warehouse keeper, filling the weighed materials in a material mixing label and transferring a subpackaging process, filling original records in time, and clearing the field according to a field clearing management system and making records after weighing one variety.

5. The technical research of the povidone-iodine film-forming infusion for medicated bath of nipples and preventing mastitis in dairy cows according to claim 4 is characterized in that: after weighing, preparing and opening a door of a liquid preparation tank, adding 50% of purified water according to the prescription amount, heating and stirring, adding auxiliary materials until the auxiliary materials are dissolved, keeping stirring, adding povidone iodine for dissolving, adding the purified water to a specified amount, sampling 50ml for qualified content and character detection, starting a liquid pump, enabling the liquid medicine to pass through a precision filter to enter the liquid storage tank, sampling and detecting, and notifying filling if the liquid medicine is qualified.

6. The technical research of the povidone-iodine film-forming infusion for medicated bath of nipples and preventing mastitis in dairy cows according to claim 5 is characterized in that: filling after preparation, directly bottling according to specification requirements, checking before operation, checking whether sundries irrelevant to production exist on a working table surface, checking whether a power supply meets requirements, whether an electromagnetic induction sealing machine is normal, whether equipment is grounded and insulated well, and whether motor steering is normal, filling a transfer sheet and transferring a packaging process after sealing by the electromagnetic induction sealing machine.

7. The technical research of the povidone-iodine film-forming infusion for medicated bath of nipples and preventing mastitis in dairy cows according to claim 6, is characterized in that: and (3) after filling, carrying out packaging box inspection, labeling the plastic bottles with labels, sampling and reserving finished products, boxing, labeling 15 bottles in each box with a certificate, labeling the box with labels on the left and right sides of the packaging box, sealing the box with adhesive tapes, inspecting the finished product samples according to quality standards, and handling temporary storage procedures of the finished products to be inspected in a finished product warehouse to be inspected.

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