CN105362212A - Washing-free sterilizing gel and preparing method thereof - Google Patents
Washing-free sterilizing gel and preparing method thereof Download PDFInfo
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- CN105362212A CN105362212A CN201510950490.6A CN201510950490A CN105362212A CN 105362212 A CN105362212 A CN 105362212A CN 201510950490 A CN201510950490 A CN 201510950490A CN 105362212 A CN105362212 A CN 105362212A
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- carbomer
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- wrist bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
The invention relates to washing-free sterilizing gel and a preparing method thereof. The gel is prepared from 0.05-2% of positive ion bactericide, 0.0005-0.02% of anionic surfactant or zwitterionic surfactant, 50-80% of ethyl alcohol, 0.05-1.5% of thickening agent, 0.1-1% of skin care humectant, 0.2-1% of neutralizer and the balance water. According to the method, the zwitterions combination technology is utilized for pretreating the positive ion bactericide to prevent the positive ion bactericide and the thickening agent from generating precipitation, and the washing-free sterilizing gel with the positive ion bactericide and the ethyl alcohol collaboratively serving as main sterilizing ingredients is prepared, is fresh and cool in hand feel and free of tack, and can effectively kill common infected germs; the hands are cared gently as a skincare ingredient is added.
Description
Technical field
the present invention relates to a kind of disposable hand-wrist bones gel and preparation method thereof.
Background technology
hospital infection, the health of patient in serious threat.Infective micro-organisms enters hospital by multiple different approach, and perches within the hospital, breeding.Because hospital personnel is complicated, comprise medical personnel, patient, rear service personnel, waste collection and disposal personnel, the public etc., very easily cause hospital infection.Both hands warm and moist, the suitable condition that the growth and breeding for antibacterial provides.Research finds, the hands of medical personnel, as the communication media of various pathogenic bacteria, is the key factor causing bacterial cross-infection.Can reduce institute's sense incidence rate to a certain extent by the frequency of washing one's hands increasing patient and medical personnel, but simple washing one's hands thoroughly can not remove pathogenic microorganism.And use suitable hand sanitizing fluid effectively can kill rapidly multiple pathogenic microorganisms on hand skin.Hand-wrist bones is the easiest, the most effectively controls the measure of hospital infection.
ethanol belongs to medium disinfectant, when concentration is 60% ~ 90%, can kill escherichia coli fast, bacillus pyocyaneus, the multiple-microorganism such as staphylococcus aureus and tubercule bacillus.Ethanol is widely used in sterilization clinically.But its disinfective action is transience, can not reach the effect of long-acting bacteriostatic.
cationic germicide comprises chlorhexidine gluconate, chlorhexidine acetate, benzyl rope chloramines, benzalkonium bromide etc.It is low that cationic germicide has toxicity, and bactericidal effect is gentle, to advantages such as skin irritation are little, has good killing action to bacterial propagule.Cationic germicide is composite with ethanol, and can greatly increase its bactericidal potency, quick-acting sterilization and persistence are all better.
the easy splash of water aqua type hand sanitizing fluid drop, drippage, gel-type then effectively can prevent splash and the drippage of disinfectant.Conventional gel-type vehicle is cellulose family and carbomer.If using hydroxypropyl emthylcellulose or hydroxyethyl-cellulose as gel-type vehicle, well composite with cationic germicide, but cellulose thickener feel sticks greasy, greatly limit its application in disposable hand sanitizing fluid.And if using carbomer as gel-type vehicle, because carbomer is anion, flocculent deposit can be produced with cationic germicide direct effect.
Summary of the invention
for above Problems existing with not enough, the invention provides a kind of disposable hand-wrist bones gel and preparation method thereof, by carbomer and cationic germicide composite, prepare with cationic germicide with the composite disposable hand-wrist bones gel for major antibacterial composition of ethanol, its stable performance, quick sterilization, long-acting bacteriostatic, clearly glutinous not greasy by rear feel, add effective skin care ingredient, the hand skin drying preventing life-time service ethanol from causing is chapped simultaneously.
the present invention, by zwitterion compounded technology, uses anion surfactant to carry out pretreatment to cationic germicide.And Anionic-cationic Surfactants Composite System, there is more powerful cooperative effect under certain condition, increase the activity of one-component.After zwitterion is composite, due to the strong sucking action between positive and negative charge, under appropriate proportioning, the two forms stable micelle.Stable micelle can be well composite with gel-type vehicle carbomer, avoids the generation of flocculent deposit.
for solving the problems of the technologies described above, the invention provides the first technical scheme: a kind of disposable hand-wrist bones gel, it is made up of the component of following mass percent: cationic germicide 0.05% ~ 2%, anion surfactant or zwitterionic surfactant 0.0005% ~ 0.02%, ethanol 50% ~ 80%, thickening agent 0.05% ~ 1.5%, skin protection wetting agent 0.1% ~ 1%, nertralizer 0.2% ~ 1%, surplus is pure water.
preferably, it is made up of the component of following mass percent: cationic germicide 0.1% ~ 1%, anion surfactant or zwitterionic surfactant 0.001% ~ 0.01%, ethanol 55% ~ 70%, thickening agent 0.1% ~ 0.5%, skin protection wetting agent 0.2% ~ 0.4%, nertralizer 0.3% ~ 0.8%, surplus is pure water.
preferably, described cationic germicide is chlorhexidine gluconate, chlorhexidine acetate, benzethonium chloride, one or more in benzalkonium bromide.
preferably, described anion surfactant or zwitterionic surfactant are lauryl alcohol phosphate kalium salt, empgen BB, one or more in methyl propylhomoserin proline.
preferably, described thickening agent is Acritamer 940, Carbopol NF, carbomer 2020, carbomer ULTREZ20, one or more in carbomer ULTREZ21.
preferably, described skin protection wetting agent is butanediol, sorbitol, PEG, Natrulon H-10, one or more in Aloe extract.
preferably, described nertralizer is triethanolamine, sodium hydroxide, one or more in DL-aminopropanol.
preferably, described cationic antibacterial, and ethanol has good synergic remove, ethanol quick sterilization, after volatilization, cationic germicide continues to play bactericidal effect, reaches the effect of long-acting bacteriostatic.
the invention provides the second technical scheme: a kind of preparation method of disposable hand-wrist bones gel, comprises the following steps:
step one: thickening agent is dispersed in 1/3 ~ 1/2 pure water, static swelling, prepare solution A;
step 2: be dispersed in by cationic germicide in 1/2 ~ 2/3 pure water, adds anion surfactant or zwitterionic surfactant, stirs, prepare B solution;
step 3: B solution is added in solution A, stir;
step 4: add ethanol successively, skin protection wetting agent stirs, and adds nertralizer and liquid is prepared into gel, filling and sealing, obtain finished product.
preferably, it is made up of following component by mass percentage: cationic germicide 0.1% ~ 1%, anion surfactant or zwitterionic surfactant 0.001% ~ 0.01%, ethanol 55% ~ 70%, thickening agent 0.1% ~ 0.5%, skin protection wetting agent 0.2% ~ 0.4%, nertralizer 0.3% ~ 0.8%, surplus is pure water, and wherein said cationic germicide is chlorhexidine gluconate, chlorhexidine acetate, benzethonium chloride, one or more in benzalkonium bromide, described anion surfactant or zwitterionic surfactant are lauryl alcohol phosphate kalium salt, empgen BB, one or more in methyl propylhomoserin proline, described thickening agent is Acritamer 940, Carbopol NF, carbomer 2020, carbomer ULTREZ20, one or more in carbomer ULTREZ21, the proportioning of anion surfactant or zwitterionic surfactant and cationic germicide is 1:1000 ~ 1:10, and described skin protection wetting agent is butanediol, sorbitol, PEG, Natrulon H-10, one or more in Aloe extract, described nertralizer is triethanolamine, sodium hydroxide, one or more in DL-aminopropanol.
beneficial effect of the present invention is as follows:
the present invention adopts zwitterion compounded technology to carry out pretreatment to cationic germicide, makes pretreated cationic germicide can be well composite with thickening agent carbomer, system clear, without precipitation.Clearly glutinous not greasy by rear feel.Solve the problem that when cationic germicide and carbomer thickening agent use simultaneously, bactericidal effect reduces.Use cationic germicide and ethanol Synergistic biocidal, can kill common pathogen fast, cationic germicide ensures long-acting bactericidal effect.The present invention with the addition of effective skin care ingredient, skin-moisturizing, skin, and prevent the hand skin drying because life-time service ethanol causes, effectively take good care of both hands, faintly acid formula, close with skin pH simultaneously, protection both hands.The disposable hand-wrist bones gel of the present invention, preparation technology is simple, without the need to heating, cost-saving.Be applicable to industrialized great production.
Detailed description of the invention
below in conjunction with embodiment, the present invention will be further described.
embodiment one
disposable hand-wrist bones gel, is made up of following formula: chlorhexidine gluconate 1g
lauryl alcohol phosphate kalium salt 0.01g
ethanol 65g
acritamer 940 0.3g
butanediol 0.2g
triethanolamine 0.4g
pure water 33.09g
and the preparation method of disposable hand-wrist bones gel is carried out as follows:
step one: 0.3g Acritamer 940 is dispersed in 20g pure water, static swelling, prepare solution A.
step 2: be dispersed in 13.09g pure water by 1g chlorhexidine gluconate, adds 0.01g lauryl alcohol phosphate kalium salt, stirs, prepare B solution.
step 3: B solution is added in solution A, stir.
step 4: add 65g ethanol successively, 0.2g butanediol stirs.Add 0.4g triethanolamine and disinfectant solution is prepared into gel, filling and sealing, obtain finished product.
embodiment two
disposable hand-wrist bones gel, is made up of following formula: chlorhexidine gluconate 0.5g
empgen BB 0.001g
ethanol 60g
carbomer 20200.35g
glycerol 0.3g
triethanolamine 0.4g
pure water 38.449g
and the preparation method of disposable hand-wrist bones gel is carried out as follows:
step one: 0.35g carbomer 2020 is dispersed in 20g pure water, static swelling, prepare solution A.
step 2: be dispersed in 18.449g pure water by 0.5g chlorhexidine gluconate, adds 0.001g empgen BB, stirs, prepare B solution.
step 3: B solution is added in solution A, stir.
step 4: add 60g ethanol successively, 0.3g glycerol stirs.Add 0.4g triethanolamine and disinfectant solution is prepared into gel, filling and sealing, obtain finished product.
embodiment three
disposable hand-wrist bones gel, is made up of following formula: chlorhexidine gluconate 0.1g
benzethonium chloride 0.1g
methyl propylhomoserin proline 0.003g
ethanol 60g
carbomer ULTREZ200.4g
sorbitol 0.4g
triethanolamine 0.5g
pure water 41.097g
and the preparation method of disposable hand-wrist bones gel is carried out as follows:
step one: 0.4g carbomer ULTREZ20 is dispersed in 20g pure water, static swelling, prepare solution A.
step 2: 0.1g chlorhexidine gluconate and 0.1g benzethonium chloride are dispersed in 21.097g pure water, adds 0.003g methyl propylhomoserin proline, stirs, prepare B solution.
step 3: B solution is added in solution A, stir.
step 4: add 60g ethanol successively, 0.4g sorbitol stirs.Add 0.5g triethanolamine and disinfectant solution is prepared into gel, filling and sealing, obtain finished product.
embodiment four
disposable hand-wrist bones gel, is made up of following formula: benzalkonium bromide 0.2g
empgen BB 0.01g
ethanol 70g
acritamer 940 0.5g
aloe extract 0.4g
triethanolamine 0.6g
pure water 30.99g
and the preparation method of disposable hand-wrist bones gel is carried out as follows:
step one: 0.5g Acritamer 940 is dispersed in 15g pure water, static swelling, prepare solution A.
step 2: be dispersed in 15.99g pure water by 0.2g benzalkonium bromide, adds 0.01g empgen BB, stirs, prepare B solution.
step 3: B solution is added in solution A, stir.
step 4: add 70g ethanol successively, 0.4g Aloe extract stirs.Add 0.6g triethanolamine and disinfectant solution is prepared into gel, filling and sealing, obtain finished product.
embodiment five
disposable hand-wrist bones gel, is made up of following formula: benzethonium chloride 0.2g
methyl propylhomoserin proline 0.002g
ethanol 55g
carbopol NF0.4g
butanediol 0.4g
triethanolamine 0.4g
pure water 43.598g
and the preparation method of disposable hand-wrist bones gel is carried out as follows:
step one: 0.4g Carbopol NF is dispersed in 20g pure water, static swelling, prepare solution A.
step 2: be dispersed in 23.598g pure water by 0.2g benzethonium chloride, adds 0.002g methyl propylhomoserin proline, stirs, prepare B solution.
step 3: B solution is added in solution A, stir.
step 4: add 55g ethanol successively, 0.4g butanediol stirs.Add 0.4g triethanolamine and disinfectant solution is prepared into gel, filling and sealing, obtain finished product.
embodiment six
disposable hand-wrist bones gel, is made up of following formula: benzethonium chloride 0.1g
methyl propylhomoserin proline 0.001g
ethanol 60g
carbomer 20200.2g
PEG0.2g
triethanolamine 0.5g
pure water 38.99g
and preparation method is carried out as follows:
step one: 0.2g carbomer 2020 is dispersed in 20g pure water, static swelling, prepare solution A.
step 2: be dispersed in 18.99g pure water by 0.1g benzethonium chloride, adds 0.001g methyl propylhomoserin proline, stirs, prepare B solution
step 3: B solution is added in solution A, stir.
step 4: add 60g ethanol successively, 0.2gPEG stirs.Add 0.5g triethanolamine and disinfectant solution is prepared into gel, filling and sealing, obtain finished product.
embodiment seven
disposable hand-wrist bones gel, is made up of following formula: benzethonium chloride 0.1g
lauryl alcohol phosphate kalium salt 0.005g
ethanol 55g
carbomer ULTREZ210.1g
butanediol 0.3g
triethanolamine 0.8g
pure water 43.695g
and the preparation method of disposable hand-wrist bones gel is carried out as follows:
step one: 0.1g carbomer ULTREZ21 is dispersed in 20g pure water, static swelling, prepare solution A.
step 2: be dispersed in 23.695g pure water by 0.1g benzethonium chloride, adds 0.005g lauryl alcohol phosphate kalium salt, stirs, prepare B solution.
step 3: B solution is added in solution A, stir.
step 4: add 55g ethanol successively, 0.3g butanediol stirs.Add 0.8g triethanolamine and disinfectant solution is prepared into gel, filling and sealing, obtain finished product.
certain above-described embodiment, only for technical conceive of the present invention and feature are described, its object is to person skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.All equivalent transformations of doing according to the spirit of main technical schemes of the present invention or modification, all should be encompassed within protection scope of the present invention.
Claims (10)
1. a disposable hand-wrist bones gel, is characterized in that it is made up of following component by mass percentage: cationic germicide 0.05% ~ 2%, anion surfactant or zwitterionic surfactant 0.0005% ~ 0.02%, ethanol 50% ~ 80%, thickening agent 0.05% ~ 1.5%, skin protection wetting agent 0.1% ~ 1%, nertralizer 0.2% ~ 1%, surplus are pure water.
2. disposable hand-wrist bones gel according to claim 1, is characterized in that: it is made up of following component by mass percentage: cationic germicide 0.1% ~ 1%, anion surfactant or zwitterionic surfactant 0.001% ~ 0.01%, ethanol 55% ~ 70%, thickening agent 0.1% ~ 0.5%, skin protection wetting agent 0.2% ~ 0.4%, nertralizer 0.3% ~ 0.8%, surplus are pure water.
3. disposable hand-wrist bones gel according to claim 1, is characterized in that: described antibacterial is cationic antibacterial, is one or more in chlorhexidine gluconate, chlorhexidine acetate, benzethonium chloride, benzalkonium bromide.
4. disposable hand-wrist bones gel according to claim 1, is characterized in that: described anion surfactant or zwitterionic surfactant are one or more in lauryl alcohol phosphate kalium salt, empgen BB, methyl propylhomoserin proline.
5. disposable hand-wrist bones gel according to claim 1, is characterized in that: described thickening agent is one or more in Acritamer 940, Carbopol NF, carbomer 2020, carbomer ULTREZ20, carbomer ULTREZ21.
6. disposable hand-wrist bones gel according to claim 1, is characterized in that: the proportioning of described anion surfactant or zwitterionic surfactant and cationic germicide is 1:1000 ~ 1:10.
7. disposable hand-wrist bones gel according to claim 1, is characterized in that: described skin protection wetting agent is one or more in butanediol, sorbitol, PEG, Natrulon H-10, Aloe extract.
8. disposable hand-wrist bones gel according to claim 1, is characterized in that: described nertralizer is one or more in triethanolamine, sodium hydroxide, DL-aminopropanol.
9. a preparation method for disposable hand-wrist bones gel, it comprises the following steps:
Step one: thickening agent is dispersed in 1/3 ~ 1/2 pure water, static swelling, prepare solution A;
Step 2: be dispersed in by cationic germicide in 1/2 ~ 2/3 pure water, adds anionic surface or zwitterionic surfactant activating agent, stirs, prepare B solution;
Step 3: B solution is added in solution A, stir;
Step 4: add ethanol successively, skin protection wetting agent stirs, and adds nertralizer and liquid is prepared into gel, filling and sealing, obtain finished product.
10. preparation method according to claim 9, is characterized in that: it is made up of following component by mass percentage: cationic germicide 0.1% ~ 1%, anion surfactant or zwitterionic surfactant 0.001% ~ 0.01%, ethanol 55% ~ 70%, thickening agent 0.1% ~ 0.5%, skin protection wetting agent 0.2% ~ 0.4%, nertralizer 0.3% ~ 0.8%, surplus is pure water, and wherein said cationic germicide is chlorhexidine gluconate, chlorhexidine acetate, benzethonium chloride, one or more in benzalkonium bromide, described anion surfactant or zwitterionic surfactant are lauryl alcohol phosphate kalium salt, empgen BB, one or more in methyl propylhomoserin proline, described thickening agent is Acritamer 940, Carbopol NF, carbomer 2020, carbomer ULTREZ20, one or more in carbomer ULTREZ21, the proportioning of anion surfactant and cationic germicide is 1:1000 ~ 1:10, and described skin protection wetting agent is butanediol, sorbitol, PEG, Natrulon H-10, one or more in Aloe extract, described nertralizer is triethanolamine, sodium hydroxide, one or more in DL-aminopropanol.
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105963147A (en) * | 2016-06-20 | 2016-09-28 | 南京巨鲨显示科技有限公司 | Hand-washing-free lipidosome disinfecting gel and preparation method thereof |
| CN106166117A (en) * | 2016-07-06 | 2016-11-30 | 湖北洁之梦生物科技有限公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN106237348A (en) * | 2016-08-18 | 2016-12-21 | 南京巨鲨显示科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN107375152A (en) * | 2017-09-07 | 2017-11-24 | 平舆玛雅生物工程有限公司 | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel |
| CN109536132A (en) * | 2018-11-27 | 2019-03-29 | 南通优护优家卫生用品有限公司 | It can be applied to the thickener of cationic sterilised products |
| CN109646375A (en) * | 2019-01-24 | 2019-04-19 | 合肥天生物技术研究所有限责任公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN110384621A (en) * | 2019-07-04 | 2019-10-29 | 杭州氢源素生物科技有限公司 | A kind of disposable hand-wrist bones gel of hydrogen-rich and preparation method thereof |
| CN110840776A (en) * | 2019-11-19 | 2020-02-28 | 上海中翊日化有限公司 | Cosmetic reagent |
| CN111297730A (en) * | 2020-02-27 | 2020-06-19 | 诚谨健康产业有限公司 | Long-acting harmless, washing-free and non-flammable macromolecular ethanol disinfectant |
| CN111388341A (en) * | 2020-03-27 | 2020-07-10 | 深圳市小雨健生科技有限公司 | Washing-free hand protection disinfectant and preparation method thereof |
| CN112370394A (en) * | 2020-12-10 | 2021-02-19 | 青岛格林维尔环保技术有限公司 | Hydrogen-rich water-containing hand-washing-free disinfection gel and preparation method thereof |
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| CN113521042A (en) * | 2021-06-28 | 2021-10-22 | 青岛童医生海洋生物科技股份有限公司 | Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof |
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| CN113952246A (en) * | 2021-12-06 | 2022-01-21 | 安福超威日化有限公司 | Cationic bacteriostatic hand-washing-free gel and preparation method thereof |
| CN114306149A (en) * | 2021-08-27 | 2022-04-12 | 中国农业科学院都市农业研究所 | Washing-free antibacterial skin-care disinfecting gel and preparation method thereof |
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Cited By (20)
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|---|---|---|---|---|
| CN105963147A (en) * | 2016-06-20 | 2016-09-28 | 南京巨鲨显示科技有限公司 | Hand-washing-free lipidosome disinfecting gel and preparation method thereof |
| CN106166117A (en) * | 2016-07-06 | 2016-11-30 | 湖北洁之梦生物科技有限公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN106237348A (en) * | 2016-08-18 | 2016-12-21 | 南京巨鲨显示科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN107375152A (en) * | 2017-09-07 | 2017-11-24 | 平舆玛雅生物工程有限公司 | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel |
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| CN109646375A (en) * | 2019-01-24 | 2019-04-19 | 合肥天生物技术研究所有限责任公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
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Application publication date: 20160302 |