CN107375152A - A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel - Google Patents
A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel Download PDFInfo
- Publication number
- CN107375152A CN107375152A CN201710799329.2A CN201710799329A CN107375152A CN 107375152 A CN107375152 A CN 107375152A CN 201710799329 A CN201710799329 A CN 201710799329A CN 107375152 A CN107375152 A CN 107375152A
- Authority
- CN
- China
- Prior art keywords
- gel
- parts
- cation
- cation sterilization
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of cation sterilization gel, every 100 parts of cation sterilization gels are made up of the raw material of following portions by weight：0.05 ~ 0.5 part of hexamidine dihydroxy ethyl sulfonate, 0.02 ~ 0.2 part of benzalkonium chloride, 0.03 ~ 0.3 part of Cetylpyridinium Chloride, 0.5 ~ 2 part of card ripple U20,0.3 ~ 1.5 part of card ripple U21,5 ~ 10 parts of propane diols, 0.5 ~ 2 part of aminomethyl propanol, surplus is water；Aloetic bacteriostatic gel product the invention also discloses the preparation method of the cation sterilization gel and comprising the cation sterilization gel.The problem of instant invention overcomes flocculent deposit can be produced after conventional anion card ripple and cationic germicide mixing, gained aloetic bacteriostatic gel product not only has active cell vigor, delay skin aging, anti-inflammatory, convergence and the skin and other effects that reconciles, also there is good anti-, fungistatic effect, and it is clearly not glutinous greasy using skin sense, have no side effect safely.
Description
Technical field
The invention belongs to sterile products technical field, and in particular to a kind of cation sterilization gel and preparation method thereof and
Aloetic bacteriostatic gel product comprising the cation sterilization gel.
Background technology
Aloe is Liliaceae, the evergreen herbage of Aloe, the characteristics of having meat thick and enriched containing juice, is had more than 300
Individual kind, is distributed widely in tropical and subtropical region.Common are representational three kinds of aloe kinds is U.S. Curacao reed
Luxuriant growth, Aloe Liliaceae and the Chinese aloe aloe.Aloe.arborescens leaf plump, best in quality, Aloe Liliaceae blade greatly
It is small and thin, and the Chinese aloe aloe growth is fast, reproductive capacity is strong.
The chemical composition of aloe mainly has two major classes, first, aloin being present near aloe leaf bottom and epidermis etc.
Quinones substance, another kind of is the aloe gel isolated from Fresh leaf of aloe parenchyma tracheid, and about 98.5% is natural moisture in gel,
Carbohydrate-mucopolysaccharide then accounts for more than the 60% of total solid, and polysaccharide is the main active in aloe gel, while reed
Contain various active enzyme, protein and organic acid isoreactivity material in luxuriant growth gel.They are to promoting the extensive of immune function of human body
It is multiple, strengthen the resistivity to a variety of diseases, improve the general level of the health and occupy highly important status, be a kind of ancient, traditional
Conventional Chinese medicine, no matter in traditional medicine or modern medicine, all affirmed the medical value of aloe, aloe is changing in recent years
There is larger application in the fields such as cosmetic, food, health products.Aloe gel is even more to have active cell vigor, delay skin aging,
Convergence, mediation skin, anti-inflammation and other effects, is very suitable external used medicine.
But in disinfecting product scope, the Aloe Vera Gel with anti-fungistatic effect（Aloetic bacteriostatic gel）, there is biography always
The problem of producing flocculent deposit after system anion card ripple and cationic germicide mixing, or use cellulose isogel agent
Existing sticky unhappy use feeling, reduce the value of aloetic bacteriostatic gel.
Rationally to utilize the Aloe resources in China, develop the aloe process deeply industry using science and technology as background, realize reed
The high added value of luxuriant growth bacteriostatic gel, therefore the formula for improving aloetic bacteriostatic gel is necessary.
The content of the invention
Based on the deficiencies in the prior art, object of the present invention is to provide a kind of cation sterilization gel, by the moon from
Subcard ripple gel and cationic germicide are made by specific proportioning and technique, overcome conventional anion card ripple and cation
The problem of producing flocculent deposit after bactericide mixing, while also improve gel and sticky unhappy use feeling be present.
The invention also discloses the preparation method of the cation sterilization gel, also discloses comprising the cation sterilization gel
Aloetic bacteriostatic gel product.
To achieve these goals, the technical solution adopted by the present invention is：
A kind of cation sterilization gel, every 100 parts of cation sterilization gels are made up of the raw material of following portions by weight：Hexamidine two
0.05 ~ 0.5 part of isethionate, 0.02 ~ 0.2 part of benzalkonium chloride, 0.03 ~ 0.3 part of Cetylpyridinium Chloride, card ripple U20 0.5 ~ 2
Part, 0.3 ~ 1.5 part of card ripple U21,5 ~ 10 parts of propane diols, 0.5 ~ 2 part of aminomethyl propanol, surplus is water.
Preferably, the cation sterilization gel, every 100 parts of cation sterilization gels by following portions by weight raw material system
Into：0.06 ~ 0.2 part of hexamidine dihydroxy ethyl sulfonate, 0.02 ~ 0.05 part of benzalkonium chloride, 0.03 ~ 0.1 part of Cetylpyridinium Chloride, card ripple
0.5 ~ 0.8 part of U20,0.3 ~ 0.5 part of card ripple U21,6 ~ 9 parts of propane diols, 0.8 ~ 1 part of aminomethyl propanol, surplus is water.
Preferably, the cation sterilization gel, every 100 parts of cation sterilization gels by following portions by weight raw material system
Into：0.1 part of hexamidine dihydroxy ethyl sulfonate, 0.04 part of benzalkonium chloride, 0.06 part of Cetylpyridinium Chloride, 0.55 part of card ripple U20, card
0.4 part of ripple U21,7 parts of propane diols, 0.9 part of aminomethyl propanol, surplus is water.
The preparation method of above-mentioned cation sterilization gel, comprises the following steps：
（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 9 ~ 11 times, obtains stock 1；
（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added
Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 50 ~ 100 DEG C, in the MPa of vacuum 0.05 ~ 0.09 bar
Constant temperature stirs 10 ~ 60 minutes under part, obtains stock 2；
（3）Stock 1 is added in stock 2, continued under conditions of 50 ~ 100 DEG C of temperature, the MPa of vacuum 0.05 ~ 0.09, constant temperature
Stirring is cooled to room temperature, produced in after homogeneous colloids.
Preferably, the preparation method of above-mentioned cation sterilization gel, comprises the following steps：
（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 10 times, obtains stock 1；
（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added
Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 80 DEG C, the constant temperature under conditions of the MPa of vacuum 0.08
Stirring 30 minutes, obtains stock 2；
（3）Stock 1 is added in stock 2, continued under conditions of 80 DEG C of temperature, the MPa of vacuum 0.08, constant temperature is stirred to being in
After homogeneous colloids, room temperature is cooled to, is produced.
The aloetic bacteriostatic gel product of above-mentioned cation sterilization gel, every 100 parts of aloetic bacteriostatic gel products are by following heavy
The raw material of amount number is made：0.8 ~ 1.0 part of aloe frozen-dried powder, 0.08 ~ 0.10 part of Sodium Hyaluronate, collagen element 0.05 ~
0.15 part, 0.02 ~ 0.05 part of metal-chelator, 0.8 ~ 1.0 part of carbohydrate NMF, surplus is cation sterilization gel.
Preferably, the metal-chelator is disodium ethylene diamine tetraacetate.
Preferably, the carbohydrate NMF is MG-60（Fructus Hordei Germinatus oligose base glucosides/hydrogenated starch hydrolysate）.
Above-mentioned raw materials are ordinary commercial products.
Wherein, the hexamidine dihydroxy ethyl sulfonate is a kind of water miscible sun with broad-spectrum antiseptic and bactericidal property
Ionic species, there are very high sterilization and biocidal property to various gram-positive bacterias and negative bacterium and various yeast and molds
Can, particularly to the pityrosporum ovale for causing dandruff, cause small pox acne propionibacterium acnes have very strong suppression and
Killing effect.
The benzalkonium chloride is the mixture of chlorodimethyl benzyl hydrocarbon ammonium, is a kind of important cation quaternary ammonium salt surface
Activating agent, there is broad-spectrum sterilization performance, bacterial cytoplasm membrane permeability can be changed, make thalline endochylema extravasation, hinder its metabolism
And killing action is played, while benzalkonium chloride also has good repairing effect to the relieving itching and eliminating swelling of skin.
The Cetylpyridinium Chloride belongs to cationic nitrogenous surfactant, is mainly used as disinfection sanitizer, is using bar on an equal basis
Under part, it is more excellent to contrast other killing rates to heterotroph, iron bacteria and sulfate reducing bacteria.
Three kinds of hexamidine dihydroxy ethyl sulfonate, benzalkonium chloride and Cetylpyridinium Chloride bactericide are used in combination, to golden yellow Portugal
Grape coccus, Escherichia coli and Candida albicans, which have, coordinates synergistic effect, makes anti-fungistatic effect more excellent.
The aloe frozen-dried powder is using aloe barbadensis Miller（Aloe vera）, it is made, saves through frozen drying method
The original activity of aloe；Described Sodium Hyaluronate is contained from 5 thousand to 120 ten thousand dalton, the hyalomitome of multiple molecular weight
Sour sodium, small molecule Transdermal absorption, macromolecular film forming moisturizing；The collagen that the collagen element ferments for Pichia pastoris
Element.
Relative to prior art, beneficial effects of the present invention are：
Cation sterilization gel of the present invention can produce wadding after overcoming conventional anion card ripple and cationic germicide mixing
The problem of shape precipitates, the aloetic bacteriostatic gel product not only remain the active cell vigor that aloe has in itself, delay skin
Skin aging, anti-inflammatory, convergence and the skin and other effects that reconciles, also have good anti-, fungistatic effect, and do not stick clearly using skin sense
It is greasy, bits are not played after drying；Three kinds of bactericide synergetics compounding, the effect of reaching anti-dandruff Synergistic, anti-acne, and also safety is not pierced
Swash, no skin dependence and side effect, consumer can be long-term use of.Aloetic bacteriostatic gel product of the present invention, not only resists
Fungistatic effect is good, and also has the moist maintenance effect better than common Aloe Vera Gel, has no side effect safely.
Embodiment
In order that the technical purpose of the present invention, technical scheme and beneficial effect are clearer, with reference to specific embodiment
Technical scheme is further illustrated, but the embodiment is intended to explain the present invention, and it is not intended that right
The limitation of the present invention, in the examples where no specific technique or condition is specified, according to the technology described by document in the art or
Condition is carried out according to product description.
Hexamidine dihydroxy ethyl sulfonate is purchased from the HDI of THOR companies in following embodiments（CAS：659-40-5）, benzene bundle
Oronain is purchased from the QT of THOR companies（CAS：68424-85-1）, Cetylpyridinium Chloride be purchased from THOR companies CPC（CAS：123-03-5）,
Card ripple U20 and card ripple U21 is purchased from Lubrizol Corp., and aloe frozen-dried powder is purchased from Yunnan ten thousand green 100：1 aloe frozen-dried powder（CAS：
8001-97-6）, Sodium Hyaluronate is purchased from Fu Ruida（CAS：9067-32-7）, collagen is plain to be purchased from the pungent general SIMPCARE in Shanghai
YCoP（CAS：9064-67-9）, it is big that disodium ethylene diamine tetraacetate is purchased from Britain's standing grain（CAS：139-33-3）, MG-60 is Japanese woods
Former company provides.
Embodiment 1
A kind of cation sterilization gel, is made up of the raw material of following portions by weight：0.1 part of hexamidine dihydroxy ethyl sulfonate, benzene
Prick 0.04 part of oronain, 0.06 part of Cetylpyridinium Chloride, 0.55 part of card ripple U20,0.4 part of card ripple U21,7 parts of propane diols, aminomethyl propanol
0.9 part, 90.95 parts of water.
The preparation method of above-mentioned cation sterilization gel, comprises the following steps：
（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 10 times, obtains stock 1；
（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added
Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 80 DEG C, the constant temperature under conditions of the MPa of vacuum 0.08
Stirring 30 minutes, obtains stock 2；
（3）Stock 1 is slowly added in stock 2, continued under conditions of 80 DEG C of temperature, the MPa of vacuum 0.08, constant temperature stirring
To reaction completely, room temperature is cooled to, is produced.
A kind of aloetic bacteriostatic gel product for including above-mentioned cation sterilization gel, every 100 parts of aloetic bacteriostatic gel products
It is made up of the raw material of following portions by weight：0.98 part of aloe frozen-dried powder, 0.08 part of Sodium Hyaluronate, 0.1 part of collagen element, second
0.04 part of edetate disodium, 0.9 part of M-60, surplus are cation sterilization gels.
The method for preparing aloetic bacteriostatic gel product using above-mentioned cation sterilization gel is by aloe frozen-dried powder, hyalomitome
Sour sodium, collagen element, disodium ethylene diamine tetraacetate and M-60 are added in cation sterilization gel and stirred and evenly mixed, and are produced.
Embodiment 2
A kind of cation sterilization gel, is made up of the raw material of following portions by weight：0.06 part of hexamidine dihydroxy ethyl sulfonate, benzene
Prick 0.02 part of oronain, 0.03 part of Cetylpyridinium Chloride, 0.5 part of card ripple U20,0.3 part of card ripple U21,6 parts of propane diols, aminomethyl propanol
0.8 part, 92.29 parts of water.
The preparation method of above-mentioned cation sterilization gel, comprises the following steps：
（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 9 times, obtains stock 1；
（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added
Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 50 DEG C, the constant temperature under conditions of the MPa of vacuum 0.09
Stirring 60 minutes, obtains stock 2；
（3）Stock 1 is slowly added in stock 2, continued under conditions of temperature 50 C, the MPa of vacuum 0.09, constant temperature stirring
To reaction completely, room temperature is cooled to, is produced.
A kind of aloetic bacteriostatic gel product for including above-mentioned cation sterilization gel, every 100 parts of aloetic bacteriostatic gel products
It is made up of the raw material of following portions by weight：0.8 part of aloe frozen-dried powder, 0.08 part of Sodium Hyaluronate, 0.05 part of collagen element, second
0.02 part of edetate disodium, 0.8 part of M-60, surplus are cation sterilization gels.
The method for preparing aloetic bacteriostatic gel product using above-mentioned cation sterilization gel is by aloe frozen-dried powder, hyalomitome
Sour sodium, collagen element, disodium ethylene diamine tetraacetate and M-60 are added in cation sterilization gel and stirred and evenly mixed, and are produced.
Embodiment 3
A kind of cation sterilization gel, is made up of the raw material of following portions by weight：0.2 part of hexamidine dihydroxy ethyl sulfonate, benzene
Prick 0.05 part of oronain, 0.1 part of Cetylpyridinium Chloride, 0.8 part of card ripple U20,0.5 part of card ripple U21,9 parts of propane diols, aminomethyl propanol 1
Part, 88.35 parts of water.
The preparation method of above-mentioned cation sterilization gel, comprises the following steps：
（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 11 times, obtains stock 1；
（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added
Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 65 DEG C, the constant temperature under conditions of the MPa of vacuum 0.07
Stirring 45 minutes, obtains stock 2；
（3）Stock 1 is slowly added in stock 2, continued under conditions of 65 DEG C of temperature, the MPa of vacuum 0.07, constant temperature stirring
To reaction completely, room temperature is cooled to, is produced.
A kind of aloetic bacteriostatic gel product for including above-mentioned cation sterilization gel, every 100 parts of aloetic bacteriostatic gel products
It is made up of the raw material of following portions by weight：1.0 parts of aloe frozen-dried powder, 0.1 part of Sodium Hyaluronate, 0.15 part of collagen element, second
0.05 part of edetate disodium, 1.0 parts of M-60, surplus are cation sterilization gels.
The method for preparing aloetic bacteriostatic gel product using above-mentioned cation sterilization gel is by aloe frozen-dried powder, hyalomitome
Sour sodium, collagen element, disodium ethylene diamine tetraacetate and M-60 are added in cation sterilization gel and stirred and evenly mixed, and are produced.
Embodiment 4
A kind of cation sterilization gel, is made up of the raw material of following portions by weight：0.05 part of hexamidine dihydroxy ethyl sulfonate, benzene
Prick 0.02 part of oronain, 0.03 part of Cetylpyridinium Chloride, 0.5 part of card ripple U20,0.3 part of card ripple U21,5 parts of propane diols, aminomethyl propanol
0.5 part, 93.6 parts of water.
The preparation method of above-mentioned cation sterilization gel, comprises the following steps：
（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 10 times, obtains stock 1；
（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added
Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 90 DEG C, the constant temperature under conditions of the MPa of vacuum 0.05
Stirring 20 minutes, obtains stock 2；
（3）Stock 1 is slowly added in stock 2, continued under conditions of 90 DEG C of temperature, the MPa of vacuum 0.05, constant temperature stirring
To reaction completely, room temperature is cooled to, is produced.
A kind of aloetic bacteriostatic gel product for including above-mentioned cation sterilization gel, every 100 parts of aloetic bacteriostatic gel products
It is made up of the raw material of following portions by weight：0.9 part of aloe frozen-dried powder, 0.09 part of Sodium Hyaluronate, 0.1 part of collagen element, second
0.03 part of edetate disodium, 0.9 part of M-60, surplus are cation sterilization gels.
The method for preparing aloetic bacteriostatic gel product using above-mentioned cation sterilization gel is by aloe frozen-dried powder, hyalomitome
Sour sodium, collagen element, disodium ethylene diamine tetraacetate and M-60 are added in cation sterilization gel and stirred and evenly mixed, and are produced.
Embodiment 5
A kind of cation sterilization gel, is made up of the raw material of following portions by weight：0.5 part of hexamidine dihydroxy ethyl sulfonate, benzene
0.2 part of oronain of bundle, 0.3 part of Cetylpyridinium Chloride, 2 parts of card ripple U20,1.5 parts of card ripple U21,10 parts of propane diols, 2 parts of aminomethyl propanol,
83.5 parts of water.
The preparation method of above-mentioned cation sterilization gel, comprises the following steps：
（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 10 times, obtains stock 1；
（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added
Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 100 DEG C, the constant temperature under conditions of the MPa of vacuum 0.06
Stirring 10 minutes, obtains stock 2；
（3）Stock 1 is slowly added in stock 2, continued under conditions of 100 DEG C of temperature, the MPa of vacuum 0.06, constant temperature stirring
To reaction completely, room temperature is cooled to, is produced.
A kind of aloetic bacteriostatic gel product for including above-mentioned cation sterilization gel, every 100 parts of aloetic bacteriostatic gel products
It is made up of the raw material of following portions by weight：0.9 part of aloe frozen-dried powder, 0.09 part of Sodium Hyaluronate, 0.1 part of collagen element, second
0.03 part of edetate disodium, 0.9 part of M-60, surplus are cation sterilization gels.
The method for preparing aloetic bacteriostatic gel product using above-mentioned cation sterilization gel is by aloe frozen-dried powder, hyalomitome
Sour sodium, collagen element, disodium ethylene diamine tetraacetate and M-60 are added in cation sterilization gel and stirred and evenly mixed, and are produced.
Aloetic bacteriostatic gel product obtained by embodiment 1 through THOR laboratories according to《Disinfection technology standard》It is required that side
Method detects, antibacterial effect such as table 1.
The antibacterial effect of the aloetic bacteriostatic gel product of table 1
, it is apparent that the aloetic bacteriostatic gel product obtained by embodiment 1 has good anti-, fungistatic effect from table 1.
Aloetic bacteriostatic gel product obtained by embodiment 1, it is following per class situations in pass through 80 volunteers（Men and women is each
40 people, the age is in 24 ~ 48 one full year of life）Tracking using effect investigation, classification and result it is as follows：
1. the common skin problem such as acne, small pox, acne：Smeared once after daily clean skin, the detumescence of same day visible dermis dispel it is red,
Symptom mitigation, skin problem disappears substantially after 3 days, and symptom substantially mitigates, and is fully recovered after one week.
2. the symptom such as allergic：10 ~ 30min, sense of discomfort substantially mitigate most of user after use, relieving itching and eliminating swelling
Rapidly, it is used continuously, can be fully recovered in 3 days, illustrate that aloetic bacteriostatic gel product has to erythema, itch etc. caused by allergic grade
The effect of obvious.
3. sunburn scald etc. is repaired：At once pain decrease can be experienced after smearing, the reparation for damaging skin is substantially added
It hurry up, the reparation for scald is accelerated more than 40%, particularly evident for the effect of sunburn, moreover it is possible to the obvious husking of containment skin and change
It is black, illustrate aloetic bacteriostatic gel product to skin because Exposure to Sunlight damages excessively or caused by accidental scalding etc. and also has good effect
Fruit.
4. bite by mosquitos：Directly smeared after bite by mosquitos, 3 min are antipruritic, subside a swelling within 30 ~ 120 minutes, illustrate that aloe presses down
Bacterium gel product has the effect of good relieving itching and eliminating swelling.
After testing, it is good to be respectively provided with good anti-fungistatic effect for the aloetic bacteriostatic gel product obtained by embodiment 2 ~ 5,
Skin problem and bite by mosquitos etc. can be directed to work, had no side effect safely.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (8)
- A kind of 1. cation sterilization gel, it is characterised in that every 100 parts of cation sterilization gels by following portions by weight raw material It is made：0.05 ~ 0.5 part of hexamidine dihydroxy ethyl sulfonate, 0.02 ~ 0.2 part of benzalkonium chloride, 0.03 ~ 0.3 part of Cetylpyridinium Chloride, card 0.5 ~ 2 part of ripple U20,0.3 ~ 1.5 part of card ripple U21,5 ~ 10 parts of propane diols, 0.5 ~ 2 part of aminomethyl propanol, surplus is water.
- 2. cation sterilization gel according to claim 1, it is characterised in that every 100 parts of cation sterilization gels are under The raw material for stating parts by weight is made：0.06 ~ 0.2 part of hexamidine dihydroxy ethyl sulfonate, 0.02 ~ 0.05 part of benzalkonium chloride, western pyrrole 0.03 ~ 0.1 part of oronain, 0.5 ~ 0.8 part of card ripple U20,0.3 ~ 0.5 part of card ripple U21,6 ~ 9 parts of propane diols, aminomethyl propanol 0.8 ~ 1 part, surplus is water.
- 3. cation sterilization gel according to claim 1, it is characterised in that every 100 parts of cation sterilization gels are under The raw material for stating parts by weight is made：0.1 part of hexamidine dihydroxy ethyl sulfonate, 0.04 part of benzalkonium chloride, Cetylpyridinium Chloride 0.06 Part, 0.55 part of card ripple U20,0.4 part of card ripple U21,7 parts of propane diols, 0.9 part of aminomethyl propanol, surplus is water.
- 4. the preparation method of any cation sterilization gel of claims 1 to 3, it is characterised in that comprise the following steps：（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 9 ~ 11 times, obtains stock 1；（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 50 ~ 100 DEG C, in the MPa of vacuum 0.05 ~ 0.09 bar Constant temperature stirs 10 ~ 60 minutes under part, obtains stock 2；（3）Stock 1 is added in stock 2, continued under conditions of 50 ~ 100 DEG C of temperature, the MPa of vacuum 0.05 ~ 0.09, constant temperature Stirring is cooled to room temperature, produced in after homogeneous colloids.
- 5. the preparation method of cation sterilization gel according to claim 4, it is characterised in that comprise the following steps：（1）Each raw material is weighed in parts by weight；Aminomethyl propanol is diluted with water 10 times, obtains stock 1；（2）By card ripple U20 and Ka Bo U21 wetting and dispersings in the water of surplus, hexamidine dihydroxy ethyl sulfonate, benzene are then added Oronain, Cetylpyridinium Chloride and propane diols are pricked, stirs and evenly mixs, is then heated to 80 DEG C, the constant temperature under conditions of the MPa of vacuum 0.08 Stirring 30 minutes, obtains stock 2；（3）Stock 1 is added in stock 2, continued under conditions of 80 DEG C of temperature, the MPa of vacuum 0.08, constant temperature is stirred to being in After homogeneous colloids, room temperature is cooled to, is produced.
- 6. a kind of aloetic bacteriostatic gel product for including any cation sterilization gel of claims 1 to 3, its feature exist In every 100 parts of aloetic bacteriostatic gel products are made up of the raw material of following portions by weight：0.8 ~ 1.0 part of aloe frozen-dried powder, hyalomitome Sour 0.08 ~ 0.10 part of sodium, 0.05 ~ 0.15 part of collagen element, 0.02 ~ 0.05 part of metal-chelator, carbohydrate NMF 0.8 ~ 1.0 Part, surplus is cation sterilization gel.
- 7. aloetic bacteriostatic gel product according to claim 6, it is characterised in that：The metal-chelator is ethylenediamine tetraacetic Acetic acid disodium.
- 8. aloetic bacteriostatic gel product according to claim 6, it is characterised in that：The carbohydrate NMF is MG-60.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710799329.2A CN107375152A (en) | 2017-09-07 | 2017-09-07 | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710799329.2A CN107375152A (en) | 2017-09-07 | 2017-09-07 | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375152A true CN107375152A (en) | 2017-11-24 |
Family
ID=60349603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710799329.2A Pending CN107375152A (en) | 2017-09-07 | 2017-09-07 | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375152A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619053A (en) * | 2018-06-20 | 2018-10-09 | 广州市惠芳日化有限公司 | Desquamation compositions, leaves shampoo and preparation method thereof |
| CN112190541A (en) * | 2020-09-27 | 2021-01-08 | 安婕妤化妆品科技股份有限公司 | Privacy care gel product |
| CN112870276A (en) * | 2019-11-29 | 2021-06-01 | 李滟徽 | Narcissus paste antibacterial gel and preparation method and application thereof |
| CN113413331A (en) * | 2020-12-30 | 2021-09-21 | 厦门中翎易优创科技有限公司 | Acne-removing composition and preparation and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101684435A (en) * | 2008-09-28 | 2010-03-31 | 福建恒安集团有限公司 | Sterilization hand washing solution |
| CN104188811A (en) * | 2014-07-30 | 2014-12-10 | 广州立白企业集团有限公司 | Foam type wash-free antibacterial liquid soap and using method thereof |
| CN105362212A (en) * | 2015-12-18 | 2016-03-02 | 南京巨鲨显示科技有限公司 | Washing-free sterilizing gel and preparing method thereof |
| CN106421217A (en) * | 2016-11-14 | 2017-02-22 | 汕头保税区洛斯特制药有限公司 | Benzalkonium chloride solution and preparation method thereof |
| CN106580870A (en) * | 2015-10-16 | 2017-04-26 | 康多宝医疗健康产品（湖南）有限公司 | Gel for treating acne and preparation method for gel |
-
2017
- 2017-09-07 CN CN201710799329.2A patent/CN107375152A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101684435A (en) * | 2008-09-28 | 2010-03-31 | 福建恒安集团有限公司 | Sterilization hand washing solution |
| CN104188811A (en) * | 2014-07-30 | 2014-12-10 | 广州立白企业集团有限公司 | Foam type wash-free antibacterial liquid soap and using method thereof |
| CN106580870A (en) * | 2015-10-16 | 2017-04-26 | 康多宝医疗健康产品（湖南）有限公司 | Gel for treating acne and preparation method for gel |
| CN105362212A (en) * | 2015-12-18 | 2016-03-02 | 南京巨鲨显示科技有限公司 | Washing-free sterilizing gel and preparing method thereof |
| CN106421217A (en) * | 2016-11-14 | 2017-02-22 | 汕头保税区洛斯特制药有限公司 | Benzalkonium chloride solution and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108619053A (en) * | 2018-06-20 | 2018-10-09 | 广州市惠芳日化有限公司 | Desquamation compositions, leaves shampoo and preparation method thereof |
| CN112870276A (en) * | 2019-11-29 | 2021-06-01 | 李滟徽 | Narcissus paste antibacterial gel and preparation method and application thereof |
| CN112190541A (en) * | 2020-09-27 | 2021-01-08 | 安婕妤化妆品科技股份有限公司 | Privacy care gel product |
| CN113413331A (en) * | 2020-12-30 | 2021-09-21 | 厦门中翎易优创科技有限公司 | Acne-removing composition and preparation and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107375152A (en) | A kind of cation sterilization gel and preparation method thereof and the aloetic bacteriostatic gel product comprising the cation sterilization gel | |
| CN112656732B (en) | Dandruff-removing and itching-relieving shampoo and preparation method thereof | |
| CN110585114B (en) | Bactericidal composition for regulating skin microbial flora and application thereof | |
| CN106109264B (en) | A kind of facial treatment mask and preparation method thereof with anti-bacteria wet keeping function | |
| CN107308014A (en) | One kind thickening suspension composition and its application | |
| CN112237559A (en) | Disinfecting composition and preparation method thereof | |
| CN111956575A (en) | Skin whitening, anti-aging and moisturizing skin care product containing aloe active substances and preparation method thereof | |
| CN111493097A (en) | Collective disinfectant for inhibiting viruses and pathogenic bacteria and preparation method thereof | |
| KR100800534B1 (en) | The dandruff preventing hair cleaner composition comprising coptis japonica root extract, mentha arrensis leaf extract and dead sea salt | |
| CN115569105B (en) | Composition containing rice hull extract for removing dandruff, controlling oil, inhibiting bacteria and removing mites | |
| CN114767561B (en) | Anti-dandruff shampoo composition | |
| KR101427462B1 (en) | Composite Natural Antiseptics From Forsythia suspensa Vahl, Leonurus sibiricus L., Crataegi fructus and Akebia quinata Decaisne, Cosmetic Compositions Containing Them | |
| CN113876666B (en) | Dandruff-removing and itching-relieving shampoo and preparation method thereof | |
| RU2500380C1 (en) | COSMETIC PRODUCT Dea vita FOR FACE AND BODY SKIN CARE | |
| CN108524339A (en) | A kind of care agent suitable for skin of face | |
| CN112274469B (en) | Traditional Chinese medicine composition and application thereof | |
| CN115670954B (en) | Wash-free private cleaning mousse and preparation method thereof | |
| CN108392456A (en) | A kind of natural skin-care dendrobium candidum surfactant and preparation method thereof | |
| WO2019007792A1 (en) | Topical compositions | |
| CN116440024B (en) | Sea collagen acne-removing repair cream from sea cucumber | |
| EP3648734A1 (en) | Topical compositions | |
| CN108498399B (en) | Compound plant extract with antiseptic effect and application thereof in cosmetic antiseptic | |
| CN113143961B (en) | Antibacterial moisturizing composite gel and preparation method and application thereof | |
| CN107308064A (en) | A kind of compound natural preservative | |
| KR20100004483A (en) | Cosmetic composition having antibiotic effect |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171124 |
|
| RJ01 | Rejection of invention patent application after publication |