CN112237559A - Disinfecting composition and preparation method thereof - Google Patents
Disinfecting composition and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention belongs to the field of disinfectants, and particularly relates to a disinfection composition and a preparation method thereof, wherein the disinfection composition comprises the following bactericidal components in percentage by mass: 0.02-0.3% of benzalkonium chloride, 0.01-0.15% of cetylpyridinium chloride, 0.02-0.3% of didecyl dimethyl ammonium chloride, 0.02-0.3% of scutellaria baicalensis extract and 0.02-0.3% of thyme extract; and the following moisture-retaining skin-care components in percentage by mass: 0.02-0.3% of tocopherol, 0.1-3% of glycerol, 0.1-3% of propylene glycol, 0.1-3% of aloe barbadensis leaf water and 0.12-2% of dendrobium officinale stem extract. The disinfection composition combines the disinfection component and the moisture-preserving skin-care component, can effectively sterilize and disinfect, has the moisture-preserving and face-beautifying functions, and is alcohol-free, mild and non-irritant.
Description
Technical Field
The invention belongs to the field of disinfectants, and particularly relates to a disinfection composition and a preparation method thereof.
Background
The disinfectant is used for killing pathogenic microorganisms on a transmission medium, so that the requirement of harmlessness is met, the pathogenic microorganisms are killed out of a human body, the transmission path of infectious diseases is cut off, and the purpose of controlling the infectious diseases is achieved. Disinfectants with antibacterial and disinfecting functions occupy a large market share. At present, disinfectants on the market are various, but the disinfection products have the following defects:
(1) the market like products have single function;
(2) the disinfection products sold in the market have no skin care function;
(3) the disinfection products sold in the market generally use single sterilization components, and the same sterilization effect is achieved, the addition amount is high, and the irritation is large;
(4) the stability is poor.
Therefore, the disinfectant used by the current users cannot meet the requirements of stability, broad spectrum, high efficiency, low use concentration, and protection and nourishing effects on the skin of the users.
Disclosure of Invention
The invention aims to provide the alcohol-free disinfection composition with the effects of sterilization, moisture retention and beauty treatment aiming at the defects of the prior art.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the disinfection composition comprises the following bactericidal components in percentage by mass: 0.02-0.3% of benzalkonium chloride, 0.01-0.15% of cetylpyridinium chloride, 0.02-0.3% of didecyl dimethyl ammonium chloride, 0.02-0.3% of scutellaria baicalensis extract and 0.02-0.3% of thyme extract.
The benzalkonium chloride, cetylpyridinium chloride and didecyl dimethyl ammonium chloride are cationic bactericides.
The Scutellariae radix extract contains baicalin, wogonoside, baicalein and wogonin, has wide antibacterial spectrum, has effects of inhibiting various bacteria and fungi, and also has antiinflammatory, antioxidant and antiallergic effects.
The thyme extract has effects of inhibiting Staphylococcus aureus and Escherichia coli, resisting bacteria and inflammation, scavenging free radicals, and resisting aging.
The benzalkonium chloride, cetylpyridinium chloride, didecyl dimethyl ammonium chloride, the scutellaria baicalensis extract and the thyme extract have disinfection and sterilization effects, and the benzalkonium chloride, cetylpyridinium chloride, didecyl dimethyl ammonium chloride, the scutellaria baicalensis extract and the thyme extract are compounded, so that the composition has synergistic sterilization effects under the condition of low dosage.
As a preferred embodiment of the invention, the disinfection composition comprises the following sterilization components in percentage by mass: 0.1% benzalkonium chloride, 0.05% cetylpyridinium chloride, 0.15% didecyldimethylammonium chloride, 0.15% Scutellaria baicalensis extract, 0.15% Thymus vulgaris extract.
Under the dosage proportion, better antibacterial and disinfection functions can be obtained.
As a preferred embodiment of the present invention, the disinfecting composition further comprises the following moisture-retaining skin-care ingredients in percentage by mass: 0.02-0.3% of tocopherol, 0.1-3% of glycerol, 0.1-3% of propylene glycol, 0.1-3% of aloe barbadensis leaf water and 0.12-2% of dendrobium officinale stem extract.
The tocopherol is a fat-soluble vitamin, is one of the most main antioxidants, can protect skin, enable the skin to have elasticity, stabilize the protein structure of cell membranes, enter skin cells to directly resist the invasion of free radicals, ultraviolet rays and pollutants, and prevent the skin from losing elasticity and even aging due to slow running or recessive damage.
The glycerin has a moisturizing function, can be used as a skin moisturizer, is high in safety performance, can form a glycerin film on the surface of skin to isolate air invasion, enables skin moisture not to be evaporated easily, can absorb air moisture to moisten the skin, and effectively prevents and treats skin cracking.
The propylene glycol is polyalcohol, is a small molecular moisturizing component, can retain moisture, plays a role in moisturizing, and also has the function of promoting skin absorption. Therefore, has the effects of moisturizing, lubricating and promoting absorption.
The aloe vera leaf water is rich in natural physiological water, mineral substances and lignin, and can directly supplement water required by the skin; is rich in monosaccharide, polysaccharide, vitamins and minerals, has obvious treatment effect on skin aging, and can reduce wrinkles; also has anti-inflammatory, antibacterial and skin repairing effects.
The dendrobium officinale stem extract is rich in dendrobium polysaccharide, dendrobine, amino acid, various trace elements and the like, and has multiple effects of moisturizing, resisting aging and wrinkles, repairing and maintaining beauty and the like.
According to the invention, tocopherol, glycerol, propylene glycol, aloe barbadensis leaf water and dendrobium officinale stem extract are selected for compounding, the combination has the effects of moisturizing, resisting oxidation, resisting aging and the like, the skin care and beautifying effects are achieved, the stimulation of sterilization components to the skin is greatly reduced, and sensitive skin can also be used.
Preferably, the disinfection composition further comprises the following moisture-retaining skin-care ingredients in percentage by mass: 0.1% of tocopherol, 1% of glycerol, 1% of propylene glycol, 0.02% of citric acid, 0.02% of sodium citrate, 0.5% of aloe barbadensis leaf water and 0.3% of dendrobium officinale stem extract.
With the dosage ratio, better moisturizing effect can be shown.
As a preferred embodiment of the present invention, the disinfecting composition further comprises the following pH adjusting agents in percentage by mass: 0.01-0.05% of citric acid and 0.01-0.05% of sodium citrate.
The invention adopts citric acid and sodium citrate to compound to form buffer solution, thereby ensuring the stability of the pH value of the system.
As a preferred embodiment of the present invention, the disinfecting composition further comprises the following preservatives in percentage by mass: 0.05-0.15% chlorphenesin, 0.2-0.6% phenoxyethanol, and 0.03-0.1% ethylhexylglycerin.
As a preferable formula, the disinfection composition comprises the following components in percentage by mass: 0.1% benzalkonium chloride, 0.05% cetylpyridinium chloride, 0.15% didecyldimethylammonium chloride, 0.15% scutellaria baicalensis extract, 0.15% thyme extract, 0.1% tocopherol, 1% glycerol, 1% propylene glycol, 0.02% citric acid, 0.02% sodium citrate, 0.5% aloe barbadensis leaf water, 0.3% dendrobium officinale stem extract, 0.08% chlorphenesin, 0.4% phenoxyethanol, 0.05% ethylhexylglycerol, and the balance of water.
Further, the present invention also provides a method for preparing the disinfecting composition, comprising the steps of:
(1) sequentially adding water, benzalkonium chloride, cetylpyridinium chloride and didecyldimethyl ammonium chloride into a melting barrel, heating, starting stirring at 30r/min, heating to 60 ℃, and keeping the temperature for 10 minutes until the materials are completely melted;
(2) cooling to 50-52 ℃, adding the premixed scutellaria baicalensis extract, thyme extract and tocopherol, and keeping the temperature for 10 minutes until the mixture is completely and uniformly dispersed;
(3) cooling to 42 deg.C, adding glycerol and propylene glycol, and stirring for 5 min; sequentially adding citric acid, sodium citrate, Aloe barbadensis leaf water, herba Dendrobii stem extract, chlorphenesin, phenoxyethanol and ethylhexylglycerin, stirring for 10 min, and dispersing;
(4) cooling to 38 deg.C, filtering, and discharging to obtain the disinfectant composition.
The disinfecting composition contains a disinfecting component and a moisturizing skin-care component, wherein benzalkonium chloride, cetylpyridinium chloride, didecyldimethylammonium chloride, a scutellaria baicalensis extract and a thyme extract in the components are synergistic, so that the disinfecting and sterilizing effects are achieved; in addition, the skin care ingredients such as tocopherol, glycerol, propylene glycol, aloe barbadensis leaf water, dendrobium officinale stem extract and the like are added to play a role in moisturizing and nourishing the skin, so that the stimulation of the sterilization ingredients to the skin is greatly reduced. The disinfection component and the moisture-preserving skin-care component of the disinfection composition are combined, so that the disinfection composition can effectively inhibit the growth of bacteria, has the moisture-preserving and face-beautifying functions, and is alcohol-free, mild and non-irritant.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1 to 5
Examples of the disinfecting composition and the method for producing the same according to the present invention are shown in table 1 for the component composition ratios.
Table 1 examples 1 to 5 the respective components account for% by mass of the disinfecting composition
Examples 1-5 methods of preparing a disinfecting composition comprising the steps of:
(1) sequentially adding water, benzalkonium chloride, cetylpyridinium chloride and didecyldimethyl ammonium chloride into a melting barrel, heating, starting stirring at 30r/min, heating to 60 ℃, and keeping the temperature for 10 minutes until the materials are completely melted;
(2) cooling to 50-52 ℃, adding the premixed scutellaria baicalensis extract, thyme extract and tocopherol, and keeping the temperature for 10 minutes until the mixture is completely and uniformly dispersed;
(3) cooling to 42 deg.C, adding glycerol and propylene glycol, and stirring for 5 min; sequentially adding citric acid, sodium citrate, Aloe barbadensis leaf water, herba Dendrobii stem extract, chlorphenesin, phenoxyethanol and ethylhexylglycerin, stirring for 10 min, and dispersing;
(4) cooling to 38 deg.C, filtering, and discharging to obtain the disinfectant composition.
Comparative example 1
The comparative example of the disinfecting composition of the present invention does not contain benzalkonium chloride, and the other composition ratios and the preparation methods are the same as those of example 2.
Comparative example 2
The comparative example of the disinfecting composition of the present invention does not contain benzalkonium chloride and cetylpyridinium chloride, and the other composition ratios and the preparation methods are the same as those of example 2.
Comparative example 3
A comparative example of a disinfecting composition of the present invention, which did not contain didecyl dimethyl ammonium chloride and Scutellaria baicalensis extract, was prepared in the same manner as in example 2.
Comparative example 4
A comparative example of a disinfecting composition according to the invention, which contains no cetylpyridinium chloride and no thyme extract, the rest of the composition and the preparation method being identical to example 2.
Comparative example 5
The comparative example of the disinfection composition does not contain aloe vera leaf water and dendrobium officinale stem extract, and the mixture ratio and the preparation method of the rest components are the same as those in example 2.
Test example 1: physical and chemical property test
The disinfecting compositions of examples 1 to 5 and comparative examples 1 to 5 were transparent, glossy, gel-like pastes, and pH values measured (1:10 aqueous diluted solution) were 6.4, 6.3, 6.5, 6.9, 6.1, 6.5, 6.2, 6.0, 5.9, and 6.1, respectively.
The disinfection compositions of the examples 1-5 and the comparative examples 1-5 are subjected to physicochemical property tests of heat resistance (45 +/-2 ℃, 2 months, room temperature recovery), cold resistance (-18 +/-2 ℃, 2 months, room temperature recovery) and cold-heat cycle (24 hours and 3 cycles respectively at the temperature of 45 ℃, normal temperature and 18 ℃) respectively, and the results are not abnormal, and the disinfection compositions of the examples 1-5 and the comparative examples 1-5 have good physicochemical stability and good weather-proof quality guarantee effect. And after completing the heat-resistant, cold-resistant and cold-hot cycles, performing the pH value test again, and measuring that the change of the pH value is kept within +/-0.5.
Test example 2: sterilization test
Bacteriostatic experiments were performed on the disinfecting compositions of examples 1 to 5 and comparative examples 1 to 5.
In the experiment, staphylococcus aureus (ATCC 6538), trichophyton schoenleinii, candida albicans (ATCC10231), malassezia furfur (ATCC 44344) and propionibacterium acnes (ATCC6919) are selected as experimental strains, and bacterial suspensions are prepared for carrying out bacteriostatic experiments, wherein the specific experimental operation refers to a bacteriostatic effect test method (suspension quantitative method) of 7.3 bacteriostatic daily chemical products in an evaluation method for antibacterial and bacteriostatic effects of daily chemical products QB/T2738-.
The experiment was repeated 3 times, the average was taken, the results were kept one decimal place, and the bacteriostatic test effects are shown in table 2, respectively.
TABLE 2 bacteriostatic ratio (%)
As can be seen from the bacteriostatic test results in Table 1, the disinfectant compositions of examples 1 to 5 all have good inhibitory effects on Staphylococcus aureus, Trichophyton schoenleinii, Candida albicans, Malassezia furfur and Propionibacterium acnes, while the disinfectant compositions of comparative examples 1 to 4 have poor bacteriostatic effects and the disinfectant composition of comparative example 5 has good bacteriostatic effects, which indicates that benzalkonium chloride, cetylpyridinium chloride, didecyldimethylammonium chloride, Scutellaria baicalensis extract and Thymus vulgaris extract have synergistic effects and play a role in disinfection and sterilization.
Test example 3: patch test
Test samples: the disinfecting compositions of examples 1 to 5 and the disinfecting compositions of comparative examples 1 to 5.
Test objects: 300 people, 20-35 years old, 200 women and 100 men, and has healthy skin and no allergic history of skin diseases. Randomly divided into 10 groups of 30 people each, and the proportion of male and female in each group is 1: 2, which correspond to the disinfecting compositions of the test examples 1 to 5 and the comparative examples 1 to 5, respectively, in units of groups.
The test method comprises the following steps: the disinfecting compositions of examples 1 to 5 and comparative examples 1 to 5 were subjected to spot test according to the method of human skin spot test in technical standards for safety of cosmetics (2015 edition), and the results were recorded according to the skin reaction grading standards.
Wherein, the skin reaction grading standard is as follows: negative reaction, grade 0. +/-., suspicious reaction, only weak erythema, grade 1. Positive reaction (erythema reaction), erythema, infiltration, edema, and pimple, grade 2. + + strong positive reaction (herpetic response), erythema, infiltration, edema, papules, herpes, response beyond the test area, grade 3. + + + +, very strong positive reaction (confluent herpes reaction), obvious erythema, severe infiltration, edema, confluent herpes, reaction beyond the test area, grade 4. The test results are shown in table 3.
TABLE 3 Patch test results for the disinfecting compositions of examples 1 to 5 and comparative examples 1 to 5
As can be seen from the test results in Table 3, the test results of the disinfecting compositions of examples 1-5 and comparative examples 1-4 are all negative reactions, no adverse reaction cases occur, and the disinfecting compositions are non-irritant to human bodies and can be safely used. The disinfectant composition of comparative example 5 showed a more pronounced suspected reaction.
Test example 4: use test
Test samples: the disinfecting compositions of examples 1 to 5 and the disinfecting compositions of comparative examples 1 to 5.
Test objects: 30 street sanitation female workers, 35-45 years old, are randomly divided into 10 groups, and each group comprises 3 persons, and the disinfection compositions of examples 1-5 and comparative examples 1-5 are respectively tried by taking the group as a unit.
The test method comprises the following steps: during the test, after the test site was first washed with clean water, the subject used the corresponding disinfecting composition.
Wherein, according to the patch test result, if severe irritative conditions (itching, stabbing pain, etc.) occur during the use of the test sample (the disinfecting composition of comparative example 5) having a suspected reaction, a large amount of clear water is used for washing in time, and the experiment is ended.
The moisture content of the subjects was measured before and after the test. The skin Moisture content was measured by a skin Moisture meter, and the Measurement result was expressed by a set Moisture Measurement Value (MMV/%).
The test results are shown in table 4.
TABLE 4 skin moisture content test results (MMV/%) before and after use of the disinfecting compositions of examples 1 to 5 and comparative examples 1 to 5
As can be seen from the test results in Table 4, the disinfecting compositions of examples 1 to 5 and comparative examples 1 to 4 can significantly increase the water content of the skin, and exhibit more excellent moisturizing effect. While comparative example 5 was less effective in increasing the moisture content of the skin.
Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the true spirit and scope of the present invention.
Claims (8)
1. The disinfection composition is characterized by comprising the following bactericidal components in percentage by mass: 0.02-0.3% of benzalkonium chloride, 0.01-0.15% of cetylpyridinium chloride, 0.02-0.3% of didecyl dimethyl ammonium chloride, 0.02-0.3% of scutellaria baicalensis extract and 0.02-0.3% of thyme extract.
2. The disinfectant composition according to claim 1, comprising the following germicidal ingredients in percentage by mass: 0.1% benzalkonium chloride, 0.05% cetylpyridinium chloride, 0.15% didecyldimethylammonium chloride, 0.15% Scutellaria baicalensis extract, 0.15% Thymus vulgaris extract.
3. The disinfectant composition according to claim 1 or 2, further comprising the following moisture-retaining skin-care ingredients in percentage by mass: 0.02-0.3% of tocopherol, 0.1-3% of glycerol, 0.1-3% of propylene glycol, 0.1-3% of aloe barbadensis leaf water and 0.12-2% of dendrobium officinale stem extract.
4. The disinfectant composition according to claim 3, further comprising the following moisture-retaining skin-care ingredients in percentage by mass: 0.1% of tocopherol, 1% of glycerol, 1% of propylene glycol, 0.02% of citric acid, 0.02% of sodium citrate, 0.5% of aloe barbadensis leaf water and 0.3% of dendrobium officinale stem extract.
5. The disinfecting composition of claim 1 or 2, further comprising a pH adjusting agent in the following mass percent: 0.01-0.05% of citric acid and 0.01-0.05% of sodium citrate.
6. The sanitizing composition according to claim 5 further comprising the following preservatives in weight percent: 0.05-0.15% chlorphenesin, 0.2-0.6% phenoxyethanol, and 0.03-0.1% ethylhexylglycerin.
7. The disinfectant composition according to claim 1, wherein said disinfectant composition comprises the following components in percentage by mass: 0.1% benzalkonium chloride, 0.05% cetylpyridinium chloride, 0.15% didecyldimethylammonium chloride, 0.15% scutellaria baicalensis extract, 0.15% thyme extract, 0.1% tocopherol, 1% glycerol, 1% propylene glycol, 0.02% citric acid, 0.02% sodium citrate, 0.5% aloe barbadensis leaf water, 0.3% dendrobium officinale stem extract, 0.08% chlorphenesin, 0.4% phenoxyethanol, 0.05% ethylhexylglycerol, and the balance of water.
8. A method of preparing a disinfecting composition as claimed in claim 7 which comprises the steps of:
(1) sequentially adding water, benzalkonium chloride, cetylpyridinium chloride and didecyldimethyl ammonium chloride into a melting barrel, heating, starting stirring at 30r/min, heating to 60 ℃, and keeping the temperature for 10 minutes until the materials are completely melted;
(2) cooling to 50-52 ℃, adding the premixed scutellaria baicalensis extract, thyme extract and tocopherol, and keeping the temperature for 10 minutes until the mixture is completely and uniformly dispersed;
(3) cooling to 42 deg.C, adding glycerol and propylene glycol, and stirring for 5 min; sequentially adding citric acid, sodium citrate, Aloe barbadensis leaf water, herba Dendrobii stem extract, chlorphenesin, phenoxyethanol and ethylhexylglycerin, stirring for 10 min, and dispersing;
(4) cooling to 38 deg.C, filtering, and discharging to obtain the disinfectant composition.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112841187A (en) * | 2021-03-31 | 2021-05-28 | 康柏利科技(苏州)有限公司 | Clothes sterilizing disinfectant and preparation method thereof |
CN113068719A (en) * | 2021-03-31 | 2021-07-06 | 康柏利科技(苏州)有限公司 | Multifunctional disinfection and sterilization liquid and preparation method thereof |
CN114403143A (en) * | 2022-01-21 | 2022-04-29 | 广州蓝月亮实业有限公司 | Anti-freezing quaternary ammonium salt composition and preparation method and application thereof |
-
2020
- 2020-10-27 CN CN202011167786.8A patent/CN112237559A/en not_active Withdrawn
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112841187A (en) * | 2021-03-31 | 2021-05-28 | 康柏利科技(苏州)有限公司 | Clothes sterilizing disinfectant and preparation method thereof |
CN113068719A (en) * | 2021-03-31 | 2021-07-06 | 康柏利科技(苏州)有限公司 | Multifunctional disinfection and sterilization liquid and preparation method thereof |
CN114403143A (en) * | 2022-01-21 | 2022-04-29 | 广州蓝月亮实业有限公司 | Anti-freezing quaternary ammonium salt composition and preparation method and application thereof |
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