CN112675104A - Skin-care disinfecting gel and preparation method thereof - Google Patents
Skin-care disinfecting gel and preparation method thereof Download PDFInfo
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- CN112675104A CN112675104A CN202011213497.7A CN202011213497A CN112675104A CN 112675104 A CN112675104 A CN 112675104A CN 202011213497 A CN202011213497 A CN 202011213497A CN 112675104 A CN112675104 A CN 112675104A
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Abstract
The invention discloses a skin-care disinfecting gel and a preparation method thereof, belonging to a skin-care product, which comprises 0.1 to 0.5 part of bactericide, 2 to 10 parts of humectant, 0.7 to 3 parts of thickener, 2 to 5 parts of emollient, 2 to 5 parts of plant extract, 1.0 to 2.0 parts of surfactant and 50 to 85 parts of deionized water in parts by weight. The dosage of quaternary ammonium salt in the skin-care disinfection gel is effectively reduced through the combination of the ammonium chloride and the like, so that the continuous disinfection effect is achieved. The thickening problem of the polyquaternium cation product is solved, the components disclosed by the invention do not contain anionic polymer or anionic surfactant components, and the problems of reaction between quaternary ammonium cation and anion and reduction of the sterilization effect are avoided. The skin care product is added with moisture-keeping components, oil and fat and emollient, and has skin protection effect for users. The formula of the alcohol-free disinfection gel is improved, and the safety is improved; the preparation of the skin-care disinfection gel provided by the invention has the characteristics of simple process and low production cost, and belongs to popularization and application.
Description
Technical Field
The invention relates to a skin care product, in particular to a skin care disinfection gel and a preparation method thereof.
Background
At present, skin disinfectants in the market are various, and common skin disinfectants mainly comprise ethanol, iodine, povidone iodine, biguanide antibacterial agents, quaternary ammonium salt compounds, triclosan and the like. Commonly used iodine-containing preparations are mainly iodine, iodine water and povidone iodine. Povidone iodine is currently the most predominant iodine-containing skin disinfectant, and is an amorphous complex of iodine in combination with a surfactant. But the color and cost of iodine preparations limits their use in everyday life. The biguanide antibacterial agent has quite strong broad-spectrum antibacterial and bactericidal effects and has effects on various bacteria, and the external antibacterial agent and the cationic surfactant have killing effects on a plurality of gram-positive bacteria and gram-negative bacteria. The principle of chlorhexidine sterilization is mainly to destroy the permeability barrier on the bacterial cytoplasmic membrane, the enzyme loses activity to achieve the sterilization effect, the low concentration can cause partial cytoplasmic leakage, and the high concentration can cause cytoplasmic condensation denaturation, thereby sterilizing. Its advantages are less irritation and less allergic reaction. Chlorhexidine has low toxicity, small irritation and no corrosiveness, and can be widely used for disinfection of mucosa, skin, operation, wound surface, instrument, appliance, etc. The biguanide antibacterial agent has good gram-positive bacteria resistance, weak gram-negative bacteria and fungi resistance, small effect on mycobacteria and no effect on spores. In vitro tests have shown efficacy against membrane-borne viruses such as herpes viruses, cytomegaloviruses, influenza viruses, but clearly less effective against membrane-free viruses such as rotaviruses, enteroviruses and adenoviruses. The quaternary ammonium salt disinfectant is a cationic surfactant, has the characteristics of low toxicity, small irritation, wide antibacterial spectrum and the like, can change the permeability of a bacterial cytoplasmic membrane, enables bacterial cytoplasmic substances to permeate outwards, and blocks the metabolism of the bacterial cytoplasmic substances to play a role in killing. They have strong bactericidal power, have inactivation effect on fat-soluble viruses, have no irritation to skin and tissues, have no toxicity to human bodies, have no corrosion to metal and rubber products, and are widely used for disinfection and sterilization of environment, food, skin mucous membranes and wounds due to excellent bactericidal performance. The result is that the composition is not compatible with anionic surfactants, which greatly limits the application range and convenience. The quaternary ammonium salt bactericide products in the current market are basically aqueous solutions or alcohol solutions of quaternary ammonium salts, and have low use convenience. The quaternary ammonium salt cation gel agent mostly adopts thickening agents such as carbomer, hydroxyethyl cellulose, xanthan gum and the like in the market at present, and the effect of the quaternary ammonium salt bactericide is greatly reduced due to the fact that the thickening agents have anions.
Disclosure of Invention
The invention aims to overcome the defects, and provides a skin-care disinfection gel and a preparation method thereof, aiming at solving the technical problems that the effect of a quaternary ammonium salt bactericide is greatly reduced, the moisture retention is insufficient, the skin irritation is large and the like caused by the influence of a formula of similar products in the prior art.
In order to solve the technical problems, the invention adopts the following technical scheme:
the invention provides a skin-care disinfection gel which comprises 0.1 to 0.5 part of bactericide, 2 to 10 parts of humectant, 0.7 to 3 parts of thickener, 2 to 5 parts of emollient, 2 to 5 parts of plant extract, 1.0 to 2.0 parts of surfactant and 50 to 85 parts of deionized water in parts by weight.
Preferably, the further technical scheme is as follows: the skin care disinfection gel also comprises 0.1 to 0.5 part by weight of essence.
Preferably, the bactericide is one or more of cymene, octyl decyl dimethyl ammonium chloride, silicone polyquaternium, dioctadecyl dimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium chloride, benzalkonium chloride, and benzalkonium bromide.
The humectant is one or more of glycerol, butanediol, propylene glycol, polyethylene glycol, and hyaluronic acid.
The thickening agent is one or more of distearyl polyoxyethylene (75) ether IPDI, distearyl polyether-100 IPDI, glyceryl polyether-7/IPDI copolymer, polyethylene glycol-240/HDI copolymer, di-decyl tetradecyl polyether-20, IPDI/PEG-15 cocoamine copolymer, IPDI/PEG-15 cocoamine/glyceryl polyether-7/polyglycerin-3 copolymer and PPG-17/IPDI/DMPA copolymer.
The emollient is one or more of dimethyl siloxane-polyether copolymer, PEG-7 olive oleate, PEG-120 jojoba oil, and water soluble oleum Armeniacae amarum.
The plant extract is one or more of Aloe extract, Paeonol, and Perillae herba extract.
The surfactant is one or more of polysorbate-n (n ═ 20,21,40,41,60,80,85), PEG-n (n ═ 20,40,60,80) sorbitan laurate, PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil.
The invention also provides a preparation method of the skin-care disinfection gel, the method comprises the following steps of weighing the bactericide, the humectant, the thickener, the emollient, the plant extract, the surfactant and the deionized water according to the skin-care disinfection gel:
1) preparing an aqueous phase system; mixing deionized water and a humectant to form a water phase, dispersing a thickening agent into the water phase, and heating to 60-85 ℃ to obtain a water phase system;
2) adding a bactericide and a surfactant into the water phase system, and stirring the mixture until the mixture is uniform to form a first mixture;
3) cooling the first mixture to a temperature below 40 ℃, adding the plant extract and the emollient thereto, and stirring uniformly to form a second mixture;
4) cooling the second mixture to room temperature to obtain the skin care and disinfection gel.
The further technical scheme is as follows: stirring the first mixture in the step 2) at a speed of 1000 r/min; stirring the second mixture in the step 3) for 10min at the speed of 200 r/min; essence is also added into the second mixture in the step 3).
Compared with the prior art, the invention has the beneficial effects of at least one of the following:
the dosage of quaternary ammonium salt in the skin-care disinfection gel is effectively reduced through the combination of the ammonium chloride and the like, so that the continuous disinfection effect is achieved.
The thickening problem of the polyquaternium cation product is solved, the components disclosed by the invention do not contain anionic polymer or anionic surfactant components, and the problems of reaction between quaternary ammonium cation and anion and reduction of the sterilization effect are avoided.
The skin care product is added with moisture-keeping components, oil and fat and emollient, and has skin protection effect for users. The formula of the alcohol-free disinfection gel is convenient to carry, and the safety is improved; the preparation of the skin-care disinfection gel provided by the invention has the characteristics of simple process and low production cost, and belongs to popularization and application.
Detailed Description
The invention is further illustrated by the following specific examples.
Example one
The embodiment provides a skin care disinfection gel, the total amount of the skin care disinfection gel prepared in the embodiment is 100g, and 0.3g of bactericide, 5.0g of humectant, 2.0g of thickener, 2.0g of emollient, 5.0g of plant extract, 1.0g of surfactant and 84.7g of deionized water are weighed according to requirements. Wherein the bactericide is a mixture of 0.2g of organosilicon polyquaternium and 0.1g of cymene, the humectant is a mixture of glycerol and butanediol in a ratio of 2:3, the thickener is distearyl polyoxyethylene (75) ether IPDI, the emollient is a mixture of PEG-7 olive oleate and PEG-120 jojoba oil in a ratio of 1:1, the plant extract is paeonol, and the surfactant is polysorbate-20.
After weighing the raw materials, preparing the skin-care disinfecting gel according to the following steps:
step 1, preparing a water phase system, mixing deionized water and a humectant to form a water phase, dispersing a thickening agent into the water phase, and heating to 60-85 ℃ to obtain the water phase system;
step 2, adding a bactericide and a surfactant into the water phase system, and uniformly stirring at the rotating speed of 1000 r/min;
step 3, cooling the mixed system obtained in the step 2 to below 40 ℃, adding the plant extract, the emollient and the essence, and stirring for 10min at the rotating speed of 200 r/min;
and 4, cooling the mixture obtained in the step 3 to room temperature, and obtaining the skin care and disinfection gel after qualified detection.
Example two
The embodiment provides a skin care disinfection gel, the total amount of the skin care disinfection gel prepared in the embodiment is 500g, and 1.5g of a bactericide, 25.1g of a humectant, 10.1g of a thickening agent, 10.1g of an emollient, 15.1g of a plant extract, 1.0g of an essence, 10.1g of a surfactant and 427.1g of deionized water are weighed according to requirements. The bactericide is a mixture of dodecyl dimethyl benzyl ammonium chloride and benzalkonium chloride in a ratio of 1:2, the humectant is a mixture of glycerol and propylene glycol in a ratio of 2:3, the thickener is IPDI/PEG-15 cocoamine/glyceryl polyether-7/polyglycerol-3 copolymer, the emollient is a mixture of PEG-7 olive oleate and PEG-120 jojoba oil in a ratio of 1:1, the plant extract is an aloe extract, and the surfactant is polysorbate-60.
After weighing the raw materials, preparing the skin-care disinfecting gel according to the following steps.
Step 1, preparing a water phase system, mixing deionized water and a humectant to form a water phase, dispersing a thickening agent into the water phase, and heating to 60-85 ℃ to obtain the water phase system;
step 2, adding a bactericide and a surfactant into the water phase system, and uniformly stirring at the rotating speed of 1000 r/min;
step 3, cooling the mixed system obtained in the step 2 to below 40 ℃, adding essence, plant extracts, emollient and essence, and stirring at the rotating speed of 200r/min for 10 min;
and 4, cooling the mixture obtained in the step 3 to room temperature, and obtaining the skin care and disinfection gel after qualified detection.
EXAMPLE III
The embodiment provides a skin care disinfection gel, the total amount of the skin care disinfection gel prepared in the embodiment is 1000g, and 4.9g of bactericide, 68.8 g of humectant, 19.7g of thickener, 19.7g of emollient, 29.5g of plant extract, 2.5g of essence, 19.7g of surfactant and 835.4g of deionized water are weighed according to requirements. Wherein the bactericide is a mixture of dodecyl dimethyl benzyl ammonium chloride and benzalkonium bromide in a ratio of 1:2, the humectant is a mixture of polyethylene glycol and propylene glycol in a ratio of 4:3, the thickener is IPDI/PEG-15 cocoamine/glyceryl polyether-7/polyglycerol-3 copolymer, the emollient is a mixture of PEG-7 olive oleate and PEG-120 jojoba oil in a ratio of 1:1, the plant extract is aloe extract), and the surfactant is polysorbate-60.
After weighing the raw materials, preparing the skin-care disinfecting gel according to the following steps.
Step 1, preparing a water phase system, mixing deionized water and a humectant to form a water phase, dispersing a thickening agent into the water phase, and heating to 60-85 ℃ to obtain the water phase system;
step 2, adding the bactericide and the surfactant into the water phase system, and uniformly stirring at the rotating speed of 1000r/min
Step 3, cooling the mixed system obtained in the step 2 to below 40 ℃, adding essence, plant extract, emollient and essence, and stirring at the rotating speed of 200r/min for 10min
And 4, cooling the mixture obtained in the step 3 to room temperature, and obtaining the skin care and disinfection gel after qualified detection.
Example four
In this embodiment, the skin care and disinfection gel prepared in the above embodiments is tested for various properties, specifically as follows:
experimental strains: staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), and Candida albicans (ATCC 10231).
The experimental method comprises the following steps: the experiment is carried out according to the minimum inhibitory concentration test (nutrient broth dilution method) of 2002 edition of Disinfection technical Specification-2.1.8.4 of Ministry of health, as shown in Table 1.
Table 1: examples 1, 2 Sterilization Rate testing
The results of the test examples 1 and 2 show that the skin-care disinfection gel can still have 99.9% of killing rate on pseudomonas aeruginosa after being diluted by 4 times, and other sterilization indexes can reach 99.9% of killing rate.
Thickening effect versus ratio table 2:
table 2: example 1 comparison with control preparation and thickening Effect
The thickening agent adopts carbomer, xanthan gum, hydroxyethyl cellulose and other anions which contain ions and have whitening or flocculation phenomenon in the process, because quaternary ammonium salt cations and the anions react. Through increasing the amount of the thickening agent, the homogenizing and stirring mixing time is increased in the technical process, the thickening effect is achieved, but the anionic thickening agent reacts part of the cationic quaternary ammonium salt, and the sterilization effect is greatly reduced.
Cold and hot test: putting the product into a transparent sealed glass bottle, refrigerating the product in a refrigerator at minus 10 ℃ for 3 months, and observing the product without deterioration; the phenomenon of layering and oil-water separation is avoided after the temperature of the constant temperature box is kept at 48 ℃ for three months; the fragrance has no obvious change.
Room temperature standing test: the sealed container is placed for 1 year at room temperature, and has no change in physical and chemical indexes, no oil-water separation and no deterioration.
Stimulation test: the experimental data are shown in table 3.
TABLE 3 results of multiple skin irritation tests of example 1 on New Zealand rabbits
In conclusion, the skin-care disinfecting gel prepared by the invention is easy to carry and use, convenient to apply and saves raw materials.
Reference throughout this specification to "one embodiment," "another embodiment," "an embodiment," etc., means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment described generally in this application. The appearances of the same phrase in various places in the specification are not necessarily all referring to the same embodiment. Further, when a particular feature, structure, or characteristic is described in connection with any embodiment, it is submitted that it is within the scope of the invention to effect such feature, structure, or characteristic in connection with other embodiments.
Although the invention has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the spirit and scope of the principles of this disclosure. More specifically, various variations and modifications are possible in the component parts and/or arrangements of the subject combination arrangement within the scope of the disclosure and claims of this specification. In addition to variations and modifications in the component parts and/or arrangements, other uses will also be apparent to those skilled in the art.
Claims (10)
1. The skin-care disinfection gel is characterized by comprising 0.1 to 0.5 part of bactericide, 2 to 10 parts of humectant, 0.7 to 3 parts of thickener, 2 to 5 parts of emollient, 2 to 5 parts of plant extract, 1.0 to 2.0 parts of surfactant and 50 to 85 parts of deionized water in parts by weight.
2. The skin care disinfecting gel of claim 1, wherein: the skin care disinfection gel also comprises 0.1 to 0.5 part by weight of essence.
3. The skin care disinfecting gel of claim 1 or 2, wherein: the bactericide is one or more of cymene, octyl decyl dimethyl ammonium chloride, organosilicon polyquaternium, dioctyl dimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium chloride, benzalkonium chloride, and benzalkonium bromide.
4. The skin care disinfecting gel of claim 1 or 2, wherein: the humectant is one or a mixture of glycerol, butanediol, propylene glycol, polyethylene glycol and hyaluronic acid.
5. The skin care disinfecting gel of claim 1 or 2, wherein: the thickening agent is one or more of distearyl polyoxyethylene (75) ether IPDI, distearyl polyether-100 IPDI, glyceryl polyether-7/IPDI copolymer, polyethylene glycol-240/HDI copolymer, di-decyl tetradecyl polyether-20, IPDI/PEG-15 cocoamine copolymer, IPDI/PEG-15 cocoamine/glyceryl polyether-7/polyglycerol-3 copolymer and PPG-17/IPDI/DMPA copolymer.
6. The skin care disinfecting gel of claim 1 or 2, wherein: the emollient is one or more of dimethyl siloxane-polyether copolymer, PEG-7 olive oleate, PEG-120 jojoba oil, and water soluble almond oil.
7. The skin care disinfecting gel of claim 1 or 2, wherein: the plant extract is one or more of aloe extract, paeonol and perilla extract.
8. The skin care disinfecting gel of claim 1 or 2, wherein: the surfactant is one or more of polysorbate-n (n =20,21,40,41,60,80,85), PEG-n (n =20,40,60,80) sorbitan laurate, PEG-40 hydrogenated castor oil, and PEG-60 hydrogenated castor oil.
9. A method for preparing skin care disinfecting gel, characterized in that the method comprises the following steps of weighing bactericide, humectant, thickener, emollient, plant extract, surfactant and deionized water according to the skin care disinfecting gel of any one of claims 1 to 8
Step A, preparing a water phase system; mixing deionized water and a humectant to form a water phase, dispersing a thickening agent into the water phase, and heating to 60-85 ℃ to obtain a water phase system;
step B, adding a bactericide and a surfactant into the water phase system, and stirring the mixture until the mixture is uniform to form a first mixture;
step C, cooling the temperature of the first mixture to be below 40 ℃, adding the plant extract and the emollient into the first mixture, and uniformly stirring the mixture to form a second mixture;
and D, cooling the second mixture to room temperature to obtain the skin care and disinfection gel.
10. The skin care disinfecting gel of claim 9, wherein: stirring the first mixture in the step B at a speed of 1000 r/min; stirring the second mixture in the step C for 10min at the speed of 200 r/min; and C, adding essence into the second mixture in the step C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113952246A (en) * | 2021-12-06 | 2022-01-21 | 安福超威日化有限公司 | Cationic bacteriostatic hand-washing-free gel and preparation method thereof |
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| CN101959509A (en) * | 2008-03-07 | 2011-01-26 | 金伯利-克拉克环球有限公司 | Alcohol antimicrobial skin sanitizing compositions including cationic compatible thickeners |
| CN104434652A (en) * | 2014-11-19 | 2015-03-25 | 铜陵麟安生物科技有限公司 | Disinfectant wipes |
| CN106038358A (en) * | 2016-06-23 | 2016-10-26 | 李建 | Efficient hand sanitizer |
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2020
- 2020-11-04 CN CN202011213497.7A patent/CN112675104A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101959509A (en) * | 2008-03-07 | 2011-01-26 | 金伯利-克拉克环球有限公司 | Alcohol antimicrobial skin sanitizing compositions including cationic compatible thickeners |
| CN104434652A (en) * | 2014-11-19 | 2015-03-25 | 铜陵麟安生物科技有限公司 | Disinfectant wipes |
| CN106038358A (en) * | 2016-06-23 | 2016-10-26 | 李建 | Efficient hand sanitizer |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113952246A (en) * | 2021-12-06 | 2022-01-21 | 安福超威日化有限公司 | Cationic bacteriostatic hand-washing-free gel and preparation method thereof |
| CN113952246B (en) * | 2021-12-06 | 2023-09-22 | 安福超威日化有限公司 | Cationic antibacterial hand-washing-free gel and preparation method thereof |
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Application publication date: 20210420 |