CN114767561B - Anti-dandruff shampoo composition - Google Patents
Anti-dandruff shampoo composition Download PDFInfo
- Publication number
- CN114767561B CN114767561B CN202210481177.2A CN202210481177A CN114767561B CN 114767561 B CN114767561 B CN 114767561B CN 202210481177 A CN202210481177 A CN 202210481177A CN 114767561 B CN114767561 B CN 114767561B
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- CN
- China
- Prior art keywords
- dandruff shampoo
- dandruff
- composition according
- shampoo composition
- composition
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002453 shampoo Substances 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 208000001840 Dandruff Diseases 0.000 title claims abstract description 48
- 241000209094 Oryza Species 0.000 claims abstract description 16
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 16
- 235000009566 rice Nutrition 0.000 claims abstract description 16
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- LUEWUZLMQUOBSB-UHFFFAOYSA-N UNPD55895 Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(OC3C(OC(O)C(O)C3O)CO)C(O)C2O)CO)C(O)C1O LUEWUZLMQUOBSB-UHFFFAOYSA-N 0.000 claims abstract description 14
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 14
- UYQJCPNSAVWAFU-UHFFFAOYSA-N malto-tetraose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(O)C(CO)O2)O)C(CO)O1 UYQJCPNSAVWAFU-UHFFFAOYSA-N 0.000 claims abstract description 14
- LUEWUZLMQUOBSB-OUBHKODOSA-N maltotetraose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O[C@@H]3[C@@H](O[C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-OUBHKODOSA-N 0.000 claims abstract description 14
- 229960002703 undecylenic acid Drugs 0.000 claims abstract description 14
- 239000000052 vinegar Substances 0.000 claims abstract description 14
- 235000021419 vinegar Nutrition 0.000 claims abstract description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims description 5
- -1 polydimethylsiloxane Polymers 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 239000003945 anionic surfactant Substances 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 239000002888 zwitterionic surfactant Substances 0.000 claims description 4
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 3
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 3
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 3
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 229920000570 polyether Polymers 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 229960004025 sodium salicylate Drugs 0.000 claims description 3
- 239000004475 Arginine Substances 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 2
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 2
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 23
- 210000004761 scalp Anatomy 0.000 abstract description 23
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 14
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 208000003251 Pruritus Diseases 0.000 description 9
- 230000007803 itching Effects 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 6
- 241000555676 Malassezia Species 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000004519 grease Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 2
- 244000303965 Cyamopsis psoralioides Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229920000289 Polyquaternium Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229940100608 glycol distearate Drugs 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229940043810 zinc pyrithione Drugs 0.000 description 2
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 2
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- CYMRPDYINXWJFU-UHFFFAOYSA-N 2-carbamoylbenzoic acid Chemical compound NC(=O)C1=CC=CC=C1C(O)=O CYMRPDYINXWJFU-UHFFFAOYSA-N 0.000 description 1
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 244000089795 Clausena lansium Species 0.000 description 1
- 235000008738 Clausena lansium Nutrition 0.000 description 1
- 241000209020 Cornus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241001289529 Fallopia multiflora Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 240000000950 Hippophae rhamnoides Species 0.000 description 1
- 235000003145 Hippophae rhamnoides Nutrition 0.000 description 1
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
- 108010013639 Peptidoglycan Proteins 0.000 description 1
- 240000005546 Piper methysticum Species 0.000 description 1
- 235000016787 Piper methysticum Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 108010013296 Sericins Proteins 0.000 description 1
- 229920002197 Sodium polyaspartate Polymers 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 1
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 1
- 230000003656 anti-hair-loss Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 230000003646 hair health Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000003212 lipotrophic effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composition which comprises the following components in parts by weight: 0.05-2 parts of chlorhexidine undecylenic acid, 1-15 parts of rice hull vinegar and 0.2-5 parts of maltotetraose; the weight percentage of the chlorhexidine undecylenic acid in the composition is 0.05-2%, the weight percentage of the rice hull vinegar in the composition is 1-10%, and the weight percentage of the maltotetraose in the composition is 0.2-5%. The composition disclosed by the invention is applied to the anti-dandruff shampoo, has a good antibacterial effect on scalp, is mild and does not irritate, and has a lasting anti-dandruff effect.
Description
Technical Field
The invention belongs to the field of daily chemicals and relates to a dandruff removing shampoo composition.
Background
Dandruff refers to the generation of macroscopic scale particles on the head, which can bring about a series of negative effects on the daily life of people. It is currently widely believed that the cause of dandruff abnormality is that scalp is sensitive due to disorder of endocrine function of the scalp and stimulation by external factors (poor shampoo and the like are used), grease is excessively secreted, and bacterial flora (lipotrophic bacteria mainly comprising malassezia) on the scalp is greatly propagated, so that keratinocytes of the scalp are keratinized too quickly, and therefore, the scalp falls off quickly. The anti-dandruff shampoo in the current market generally achieves the anti-dandruff effect by adding antibacterial components such as Zinc Pyrithione (ZPT) and the like, but has certain limitations, is bad in use feeling, is easy to generate resistance on scalp, and has bad long-term use effect.
Chinese patent application CN 114028285A discloses a shampoo containing cornus extract, and a preparation method and application thereof, wherein the shampoo comprises the following components in percentage by mass: 0.05-2% of aqueous extract of the fruit of the Chinese wampee, 10-16% of sodium laureth sulfate, 3-8% of cocamidopropyl betaine, 0.2-5% of sodium chloride, 2-5% of ammonium laurylsulfate, 1-3% of cocamide MEA, 1-3% of softener, 1-3% of glycol distearate, 0.2-2% of malto-oligosaccharide glucoside, 0.2-2% of hydrogenated starch hydrolysate, 0.1-1% of sea buckthorn fruit oil, 0.1-1% of allantoin, 0.02-0.8% of EDTA disodium, 0.020.8% of chlorphenicol, 0.02-0.8% of citric acid, 0.1-0.8% of DMDM hydantoin, 0.1-0.6% of polyquaternium and the balance of water. The shampoo can clean hair and scalp, remove dandruff, balance scalp grease secretion, promote head blood circulation and have special effects on protecting scalp and hair health.
Chinese patent application CN 112315858A discloses an anti-hair-loss, hair-nourishing and anti-dandruff shampoo and a preparation method thereof, and relates to the technical field of shampoos. The material comprises the following raw materials in parts by weight: phase A: 64.25-80% of water, 0.1-0.5% of EDTA disodium, 0.05-0.1% of citric acid, 14-20% of laureth ammonium sulfate, 6-10% of laureth ammonium sulfate, 0.1-0.5% of PEG-7M polyethylene glycol, 0.2-0.5% of guar hydroxypropyl trimethyl ammonium chloride, 0.3-1% of polyquaternium, 0.6-2% of bis (hydrogenated tallow) phthalic acid amide, 1.5-3% of ethylene glycol distearate and 0.6-2% of cocoamide DEA; and B phase: 0.3-1% of DMDM hydantoin, 0.8-2% of hydrolyzed silk, 4-10% of myristoyl sarcosine sodium, 0.5-2% of sodium polyaspartate, 0.5-1% of essence, 1.2-2% of sodium chloride, 1-2% of dodecyl sulfate TEA salt, 2-5% of polydimethylsiloxane, 1-3% of polygonum multiflorum extract and 1-5% of sericin. The shampoo prepared by the invention can clean hair and scalp under the combined action of various raw materials, effectively balance scalp grease, relieve head nerves and play a role in preventing alopecia. However, the two disclosed shampoos mainly achieve the effects of removing dandruff and relieving itching by adjusting the water-oil balance of the scalp, have no corresponding solution to the main microbial problems in the dandruff problem, and have limited and slow effects only by balancing the scalp grease.
Therefore, it is necessary to explore a shampoo composition which is mild, has lasting anti-dandruff effect and has a certain antibacterial effect.
Disclosure of Invention
Aiming at the problems that the use feeling of the anti-dandruff shampoo on the market is poor, the scalp is easy to generate resistance, and the anti-dandruff effect is poor after long-term use, the invention provides the anti-dandruff shampoo composition which is mild, non-irritating, strong in antibacterial capability and good in anti-dandruff effect.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
first, a composition is provided comprising the following components: chlorhexidine undecylenic acid, rice hull, and maltotetraose.
Further, the composition comprises the following components in parts by weight: 0.05-2 parts of chlorhexidine undecylenic acid, 1-15 parts of rice hull vinegar and 0.2-5 parts of maltotetraose.
Further, the weight ratio of the chlorhexidine undecylenic acid, the rice hull vinegar and the maltotetraose in the composition is 0.05-2:1-10:0.2-5.
Further, the weight percentage of the chlorhexidine undecylenic acid in the composition is 0.05-2%, the weight percentage of the rice hull vinegar in the composition is 1-10%, and the weight percentage of the maltotetraose in the composition is 0.2-5%.
As can be seen from the chemical structure (I) of the chlorhexidine undecylenic acid in the composition, the chlorhexidine undecylenic acid contains a large number of positively charged nitrogen atoms and negatively charged carboxyl groups, and because of the large cationic charge density and electronegativity, the negative charge of the carboxyl groups is neutralized by the positive charges carried by the nitrogen atoms along with carbon chain transfer, so that the whole molecule is cationic, belongs to cationic organic matters, and forms hydrophobic adsorption with fungus cell walls (peptidoglycan); meanwhile, a large amount of positively charged nitrogen ions contained in the shampoo can promote the adsorption of the shampoo to the surface of a negatively charged thallus, the hydrophobic chain of the shampoo penetrates into the lipoid layer of the thallus cell membrane through permeation and diffusion to change the permeability of the cell membrane, so that the thallus is broken, in addition, hydrophilic groups (carboxyl) penetrate into proteins to cause enzyme to lose activity and protein denaturation, the shampoo has strong bactericidal effect and almost no drug resistance due to the combined effect of the two effects, and the shampoo can not have the effect of reducing the bactericidal and antibacterial functions along with overlong use time, has stable property, does not react with other raw materials to reduce the effect, and has low irritation, so that the shampoo can play a good role in inhibiting and removing dandruff when being added into the shampoo. The rice hull vinegar in the composition is a complex mixture of components, and contains 57.71% of phenols, 13.33% of organic acids, 12.63% of ketones, 3.77% of alcohols, 1.04% of aldehydes, 0.48% of esters and the like, wherein the phenol content is the highest, and the acids and the ketones are the next. The acid substance can dissolve lipid to denature protein and damage cell membrane of microorganism; the phenolic substances can be cracked and penetrate through the cell wall of the microorganism to coagulate and precipitate the mycoprotein, so that the permeability of the cell wall is increased and the content of the thallus is escaped; the alcohol substances can invade the cells of the bacteria by destroying peptide bonds of the proteins to denature the proteins, release water films on the surfaces of the proteins to deactivate the proteins, cause the metabolism disorder of the microorganisms and kill the microorganisms through the bacteriolysis. On one hand, rice hull vinegar is added into shampoo to be used as an antibacterial component; on the other hand, the esters contained in the hair cream have certain permeability, and can supplement nutrient components to the deep part of the scalp; the acetic acid also can soften scalp cuticle, has astringing effect, and has synergistic effect on effective components and relieving scalp. The maltotetraose in the composition is derived from plants, has excellent itching relieving and soothing effects, can improve the water content of the horny layer, reduce the irritation to the scalp, and has a certain repairing and soothing effect on the scalp.
Further, the composition also comprises the following components: anionic surfactant, nonionic surfactant, zwitterionic surfactant, conditioner, pearling agent, thickener, preservative, pH regulator and essence.
Further, the anionic surfactant comprises one or two of sodium lauroyl sarcosinate and sodium dodecyl polyether sulfate.
Further, the nonionic surfactant comprises one or two of cocamide MEA and cocamidomethyl MEA.
Further, the conditioning agent comprises one or more of guar hydroxypropyl trimethyl ammonium chloride, polyquaternium-10 and polydimethylsiloxane.
Further, the zwitterionic surfactant comprises sodium lauroyl amphoacetate, the pearlizing agent comprises ethylene glycol distearate, the thickening agent comprises sodium chloride, the preservative comprises sodium benzoate and/or sodium salicylate, and the pH regulator comprises citric acid and/or arginine.
Further, the use of the composition in the preparation of anti-dandruff shampoos.
In some specific embodiments, the preparation method of the anti-dandruff shampoo composition comprises the following steps (the components are added according to the formula amount):
(1) Adding polyquaternium-10 into water while stirring, heating to 60 ℃, and uniformly dissolving;
(2) Sequentially adding sodium lauroyl amphoacetate, sodium dodecyl polyether sulfate, cocamide MEA and glycol distearate into the solution in the step (1), stirring and heating to 85 ℃, preserving heat for 25 minutes, and cooling after uniform dissolution;
(3) Cooling to 45 ℃, sequentially adding chlorhexidine undecylenic acid, rice hull vinegar, maltotetraose, essence, sodium benzoate, sodium salicylate, sodium chloride and citric acid into the solution in the step (2) one by one, uniformly stirring, and discharging.
The preparation method of the rice hull vinegar comprises the following steps:
(1) Loading rice hulls into a carbonization kettle, and connecting condensation recovery equipment;
(2) Setting the cracking temperature to 400-500 ℃, and collecting condensate;
(3) Standing the condensate liquid, and taking the middle light red clear liquid as rice hull vinegar.
Compared with the prior art, the invention has the following beneficial effects:
(1) The anti-dandruff shampoo composition has good antibacterial effect and can maintain micro-ecological balance of scalp;
(2) The anti-dandruff shampoo composition can soften the horny layer, so that nutrient components better enter the scalp to be absorbed, has a certain repairing effect on the horny layer of the scalp, improves the water content of the horny layer, does not become chapped and sensitive, and better resists the stimulation caused by the outside;
(3) The anti-dandruff shampoo composition of the invention is mild and does not irritate.
Detailed Description
It is to be noted that the raw materials used in the present invention are all common commercial products, and the sources thereof are not particularly limited.
The following reagents and instrument sources are exemplary illustrations: maltotetraose (japanese forest company, maltotetraose), chlorhexidine undecylenic acid (seliex, salbact, salicylatesand Chemicals), the platinum activated plentiful amino acid shampoo of comparative example 8 (KKP 2B 20231013), the calendula oil control shampoo of comparative example 9 (X202502 2051186434), the oil control fluffy shampoo of comparative example 10 (T20210920 8263R 52311), the malassezia species (beijing hua transoceanic organism, NRR 00230), the culture medium (cyclic kava microorganism limited, mangaku red culture medium).
1. Composition formula of anti-dandruff shampoo
Examples 1 to 3
Table 1 shows the compositions of the formulations of the anti-dandruff shampoo compositions of examples 1-3.
TABLE 1
Note that: in the above table, to 100 represents the sum of the parts by weight of water added and the parts by weight of the other components To be 100 parts.
Table 2 shows the compositions of the formulations of the anti-dandruff shampoo compositions of comparative examples 1-7.
TABLE 2
Note that: in the above table, to 100 represents the sum of the parts by weight of water added and the parts by weight of the other components To be 100 parts.
Comparative examples 8 to 10
Commercial sea-fly-wire anti-dandruff shampoo was used as comparative example 8; commercial cleaning and anti-dandruff shampoo was used as comparative example 9; a commercially available Kangwang anti-dandruff shampoo was used as comparative example 10.
The preparation method of the anti-dandruff shampoo composition comprises the following steps:
(1) Adding polyquaternium-10 into water while stirring, heating to 60 ℃, and uniformly dissolving;
(2) Adding the raw materials of phase B into phase A one by one according to the sequence in tables 1 and 2, stirring and heating to 85 ℃, preserving heat for 25 minutes, and cooling after uniform dissolution;
(3) Cooling to 45deg.C, adding C phase materials one by one according to the sequence shown in tables 1 and 2, stirring, and discharging.
Physical and chemical indexes and sanitation indexes of the anti-dandruff shampoo compositions prepared in examples 1-3 and comparative examples 1-7 are within the requirements of GB/T29679-2013.
2. Anti-dandruff effect test
1. Irritation test
Selecting 26 healthy mice, dividing the mice into 13 groups, removing the hair of each group of two mice, wherein the hair removing area of each block is 2cm multiplied by 2cm; the shampoo of examples 1-3 and comparative examples 1-10 is applied to the dehaired parts 1 time a day, 3g each time, the retention time is 30min, and continuous observation is carried out for 28d; the shampoos of examples 1-3, comparative examples 1-10 were formulated as 1:10, soaking the patch film cloth in the water solution for 3min, then pasting the patch film cloth on a dehairing place for 15min, and continuously observing for 28d. The judgment standard is as follows: redness (stimulation, 3 minutes); slightly reddish (slightly stimulated, score 1); no change (no stimulus, score 0), results are shown in table 3 below:
TABLE 3 Table 3
From the scoring results in Table 3, the shampoos of examples 1-3 were mild and superior to other comparative examples and the like.
2. Consumer group test (sensory test)
Selecting 130 subjects aged 18-50 years without pathological seborrheic dermatitis, randomly dividing the subjects into 13 groups, taking shampoo of examples 1-3 and comparative examples 1-10 by 10 persons in each group, washing 3g of shampoo every night, rubbing the shampoo for one minute, washing with water, continuously taking trial for 28d, and evaluating; the evaluation criteria were divided into two indices of dandruff and itching, the dandruff score (each group removed the lowest and highest score, based on average): score 1 indicates large chips, score 2 indicates small to medium sized chips, score 3 indicates slightly small powdery chips, score 5 indicates no chips, and the itch rating (each group removes the highest rating and lowest rating, based on average): a represents no itching, B represents slight itching, C represents itching, D represents very itching, and the evaluation results are shown in table 4 below:
TABLE 4 Table 4
As can be seen from the results in the table, the shampoos of examples 1-3 are excellent in anti-dandruff effect, do not itchy, and are superior in feel to the comparative examples 1-7 and the like.
3. Antibacterial effect test of malassezia
The test basis is as follows: the measurement is carried out by referring to a suspension quantitative bacteriostasis test method in WS/T650-2019, and the experimental strain is malassezia.
The experimental method comprises the following steps: fresh slant cultures of test bacteria were washed with PBS and diluted to about 5.0X10 s with PBS 5 -4.5×10 6 CFU/mL bacterial suspension was used. Taking a sterile test tube, firstly adding 5.0mL of sample, placing in a water bath at 20+/-1 ℃ for 5min, then adding 0.1mL of test bacterial suspension, quickly and uniformly mixing, respectively sucking 1.0mL of test bacterial and sample mixed solution, inoculating 2 plates, and pouring the culture medium. When the bacterial count is unable to be counted, PBS is used for serial dilution of 10 times, and 2 plates are inoculated by respectively sucking 1.0mL of the suitable dilution to obtain the viable bacteria culture count. At the same time, PBS was used instead of the sample for parallel experiments as positive control. The number of colonies recovered by positive control was 1.0X10 4 -9.0×10 4 CFU/mL. The same batch of PBS and medium was used as negative control. All test and control samples were incubated at 36.+ -. 1 ℃ for 72h to observe the final results. The test was repeated 3 times and the bacteriostatic rate was calculated.
The calculation formula of the bacteriostasis rate is as follows: x= (a 0 -A 1 )/A 0 X 100%, wherein: x is the antibacterial rate, and the unit is; a is that 0 The average colony count of the control sample, CFU/mL; a is that 1 CFU/mL was the average colony count of the test samples.
And (3) result judgment: the antibacterial rate is between 50 and 90 percent, and has antibacterial effect; the bacteriostasis rate is more than or equal to 90 percent, and has stronger bacteriostasis effect.
TABLE 5
The results of bacteriostasis in Table 5 show that the shampoos of examples 1-3 have a strong inhibition effect on malassezia and excellent bacteriostasis.
The results well prove that the anti-dandruff shampoo of the examples 1-3 has strong antibacterial capability, obvious and mild anti-dandruff effect and good use experience.
Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.
Claims (9)
1. An anti-dandruff shampoo composition, which is characterized by comprising the following components: chlorhexidine undecylenic acid, rice hull vinegar, and maltotetraose; the weight ratio of the chlorhexidine undecylenic acid, the rice hull vinegar and the maltotetraose in the composition is 0.05-2:1-10:0.2-5.
2. The anti-dandruff shampoo composition according to claim 1, wherein said composition comprises the following components in parts by weight: 0.05-2 parts of chlorhexidine undecylenic acid, 1-10 parts of rice hull vinegar and 0.2-5 parts of maltotetraose.
3. An anti-dandruff shampoo composition according to any of claims 1-2, wherein the weight percentage of chlorhexidine undecylenic acid in the composition is from 0.05 to 2%, the weight percentage of rice hull vinegar in the composition is from 1 to 10%, and the weight percentage of maltotetraose in the composition is from 0.2 to 5%.
4. An anti-dandruff shampoo composition according to any one of claims 1-2, wherein said composition further comprises the following components: anionic surfactant, nonionic surfactant, zwitterionic surfactant, conditioner, pearling agent, thickener, preservative, pH regulator and essence.
5. The anti-dandruff shampoo composition according to claim 4, wherein said anionic surfactant comprises one or both of sodium lauroyl sarcosinate, sodium dodecyl polyether sulfate.
6. The anti-dandruff shampoo composition according to claim 4, wherein said nonionic surfactant comprises one or both of cocamide MEA, cocamidomethyl MEA.
7. The anti-dandruff shampoo composition according to claim 4, wherein said conditioning agent comprises one or more of guar hydroxypropyl trimethylammonium chloride, polyquaternium-10, and polydimethylsiloxane.
8. The anti-dandruff shampoo composition according to claim 4, wherein said zwitterionic surfactant comprises sodium lauroyl amphoacetate, said pearlizing agent comprises ethylene glycol distearate, said thickener comprises sodium chloride, said preservative comprises sodium benzoate and/or sodium salicylate, and said pH adjuster comprises citric acid and/or arginine.
9. Use of an anti-dandruff shampoo composition according to any of claims 1-8 in the preparation of an anti-dandruff shampoo.
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| CN103918726A (en) * | 2014-04-18 | 2014-07-16 | 安徽省淮北市农药厂 | Method for preparing bactericide from rice hulls |
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| CN113440449A (en) * | 2021-06-11 | 2021-09-28 | 泉后(广州)生物科技研究院有限公司 | Anti-dandruff composition and application thereof |
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| CN103918726A (en) * | 2014-04-18 | 2014-07-16 | 安徽省淮北市农药厂 | Method for preparing bactericide from rice hulls |
| CN109864933A (en) * | 2019-04-20 | 2019-06-11 | 福建省梦娇兰日用化学品有限公司 | A kind of hair of children cleaning compositions of not silicate-containing oil and preparation method thereof |
| CN113440449A (en) * | 2021-06-11 | 2021-09-28 | 泉后(广州)生物科技研究院有限公司 | Anti-dandruff composition and application thereof |
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