CN102525841A - Marine organism bacterium-removal oral care liquid - Google Patents
Marine organism bacterium-removal oral care liquid Download PDFInfo
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- CN102525841A CN102525841A CN2011104234476A CN201110423447A CN102525841A CN 102525841 A CN102525841 A CN 102525841A CN 2011104234476 A CN2011104234476 A CN 2011104234476A CN 201110423447 A CN201110423447 A CN 201110423447A CN 102525841 A CN102525841 A CN 102525841A
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- marine organisms
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Abstract
The invention relates to a marine organism bacterium-removal oral care liquid which can be suitable for cleaning, sterilizing and caring oral cavities, and can effectively improve the health conditions of teeth, periodontium and oral cavities, remove peculiar smell and keep oral cavities fresh, clean and healthy. The marine organism bacterium-removal oral care liquid has the characteristics of distinct sterilization effect, no toxicity and stimulation, stable chemical property, convenience and practicality, simple production procedure and the like. The marine organism bacterium-removal oral care liquid is characterized in that the liquid has the following formula (components and weight percentages thereof: 1.0-2.0% of beta-chitosan quarternary ammonium hyaluronic acid derivatives, 0.5-1.0% of seaweed polysaccharides derivatives, 6.0-8.0% of marine organism alpha-spiral sterilization peptides, 0.5-1.0% of biological enzymes, 0.5-1.5% of polyhexamethylene guanidine and the balance of reverse-osmosis purified water.
Description
Technical field
The present invention relates to a kind of marine organisms degerming oral nursing liquid, effective ingredient marine organisms plain Sargassum polysaccharides analog derivative alive, β-chitosan quaternary ammonium hyaluronic acid analog derivative, Sargassum polysaccharides analog derivative, marine organisms alpha-helix cecropin and enzyme and cationic polymerization guanidine are prepared from through special process.Can be used for cleaning, antibacterial, the nursing in oral cavity.Can effectively improve the health status in tooth, periodontal, oral cavity.Dispelling abnormal flavor, keep the pure and fresh, salubrious, healthy of oral cavity.
Background technology
The kind of existing oral care product is a lot of in the market, and performance differs, and the branch of high, medium and low effect is arranged; Mostly be quaternary ammonium salt, chloride type or antibiotic effective ingredient, can not use separately, with after need gargle with clear water; Product of the present invention is a marine organism extract, swallows nontoxicly, need not the reuse clear water and gargle, and life-time service has no drug resistance.
Summary of the invention
Main points of the present invention are to select suitable component, and rationally are mixed, and form a kind of marine organisms degerming oral nursing liquid through blending emulsion reaction.
The prescription that the present invention selects is (component and percentage by weight % thereof) as follows:
β-chitosan quaternary ammonium hyaluronic acid analog derivative 1.0-2.0;
Sargassum polysaccharides analog derivative 0.5-1.0;
Marine organisms alpha-helix cecropin 6.0-8.0;
Enzyme 0.5-1.0;
Cationic polymerization guanidine 0.5-1.5
The reverse osmosis pure water adds to 100.
β-chitosan quaternary ammonium hyaluronic acid analog derivative, Sargassum polysaccharides analog derivative, marine organisms alpha-helix cecropin are as the main sterilizing component; Join in the mixture in proportion; Purpose is through its characteristic; Can destroy the cell membrane of noxious bacteria, cause bacterial body internal protein and nucleic acid irreversible denaturation, thereby cause that cell dysfunction causes bacterial death.Can also suppress the synthetic of bacteria cell wall, especially extremely responsive such as staphylococcus aureus, β Hemolytic streptococcus etc. to most of gram-positive bacterium, fungus is also shown stronger killing action.
The cationic polymerization guanidine is the high molecular polymer of long-chain, and guanidine radicals has very high activity, makes polymer become electropositive; Usually be electronegative each bacterioid, virus is easy to be adsorbed; Then can firmly antibacterial be twined, thereby suppress the splitting function of antibacterial, make antibacterial, virus lose reproductive performance with virus; Add that polymer molecule has stopped up the respiration channel of microorganism, is choked to death microorganism rapidly.In addition,, be difficult for being absorbed by animal body inner tissue because the unique high molecular polymer long chain type structure of cationic polymerization guanidine does not contain heterocyclic group, thus zooblast there is not toxicity, thus can accomplish human non-toxic.And its unique physical sterilization mechanism can not develop immunity to drugs each bacterioid, virus through the DNA variation to it, thereby reaches fast, wide spectrum, the stable effect of killing all kinds of bacterial viruses.Antimicrobial spectrum is wider, and is all effective to Gram-positive and negative bacterium and mycete, have colourless, do not have smell, to skin nonirritant, avirulence, non-corrosive characteristics.
Enzyme can improve bacteria-eliminating efficacy as the synergistic component in this prescription.
Marine organisms plain bacteria remover alive by marine organisms plain Sargassum polysaccharides analog derivative alive, β-chitosan quaternary ammonium hyaluronic acid analog derivative, Sargassum polysaccharides analog derivative, marine organisms alpha-helix cecropin and enzyme are formed, passed through the check of following mechanism:
1, proof detects in Qingdao Municipal Center For Disease Control & Prevention: the effective ingredient of composite parts is 0.8%,
Using the effective ingredient of liquid is 0.4%, will use liquid dilution 1:30-1:40 doubly, under the action time of 2-5min, can effectively kill escherichia coli, staphylococcus aureus, Candida albicans, and sterilizing rate is 99.99%;
2, the anti-sterilization of doctor professional technique center is detected through Qingdao: according to Ministry of Health of the People's Republic of China
" disinfection technology standard " toxic grade scale judges that being tried thing marine organisms plain bacteria remover alive is actual innocuous substance to chmice acute toxicity; To the skin nonirritant; To laboratory animal eyes nonirritant; Slight to the laboratory animal vaginal mucosa irritation for extremely.Laboratory animal is not seen skin allergic reaction; PCEMNR there is not the micronucleus of causing effect; Mice there is not the sperm deformity of causing effect, to the male sex-cell hereditary-less toxicity; To laboratory animal is weak cumulative toxicity, cumulative coefficient K>5.No teratogenesis, carcinogenic, mutagenic action meet disinfectant pollution-free food medicament usage criteria, AA level pollution-free food level.
Marine organisms plain bacteria remover PH alive is PH7.89; Colourless, tasteless, noresidue, pollution-free; Right
The equal ﹤ 0.01mm/a of the corrosion rate of four kinds of sheet metals does not have corrosion basically.
Marine organisms live, and plain bacteria remover is soluble in water, natural degradation soon, does not contain heavy metal, can improve quality, environmental quality, does not destroy the biological antiseptic liquid of bio-safety system.The regulation that each item index all is up to state standards meets the pertinent regulations of " People's Republic of China's law on the prevention and control of infectious diseases " and " Regulations of sterilization management "; Meet pertinent regulations such as HACCP system.
3, the technical information center update search proves through Shandong: domestic not finding looked into new the point with this project (retrieval is looked into new domesticly had no-trump β-chitosan quaternary ammonium hyaluronic acid analog derivative+Sargassum polysaccharides analog derivative+marine organisms alpha-helix cecropin+enzyme+polyhexamethylene guanidine to process the live bacteria remover of plain biological prescription of marine organisms in proportion.Especially degerming efficient height, good stability, harmful to human non-toxic, security performance is high and all kinds of bacterium (poison) HIV of first, second, third, fourth, viruses such as all kinds of hepatitis such as penta, sexually transmitted disease (STD) all had the identical research and the product report of the said prescription of sterile products of the professional marine organisms type of characteristics such as special killing action.
Qingdao City science and technology office organizes the conclusion of " the scientific and technological achievement evaluation " of experts' evaluation to be: this project is extracted active substance from marine organisms; And it is composite with other antimicrobial components; Developed the novel degerming product that bactericidal effect is remarkable, toxic and side effects is little, having overcome bacteria remover is the drawback of pure chemistry article.Compare with traditional antibacterial, this project achievement is raw material with the composition of biogenetic derivation, and is functional; Environmental friendliness can promote antibacterial degerming product to efficient, innoxious development, progressively substitutes generation product; Not only can be the menu bit strip and come significantly economic benefit, social benefit is good simultaneously.Compare with similar research and method, this achievement integral body is on the leading domestic level.
A kind of method for preparing of marine organisms degerming oral nursing liquid is:
(1) by proportioning said component β-chitosan quaternary ammonium hyaluronic acid analog derivative, Sargassum polysaccharides analog derivative and cationic polymerization guanidine are added in the aqueous solution, stir;
(2) by proportioning said component marine organisms alpha-helix cecropin is added stirring, mix homogeneously;
(3) add enzyme by proportioning, go the reverse osmosis pure water to add to 100, stir;
(4) detect qualified after, packing.
A kind of marine organisms degerming oral nursing liquid is compared with existing oral care product has following advantage:
(1) sterilization effect is remarkable, and pathogenic bacterium sterilizing rates such as the suppuration bacterium that causes oral inflammation, fungus are reached 99.99%; Effectively remove halitosis
(2) antibacterial, inhibition time are long;
(3) do not contain any medicine and hormone composition,, can't help the seam clothes health totally nontoxic, non-stimulated;
(4) these article are the macromole gum polymers, and chemical property is very stable, 3 years effect duration;
(5) applied range can be used for various crowds' mouth cavity daily nursing, improves oral healthy condition, also can be used for the oral cavity because treatment of diseases such as bacterial gingivitis, apicitis, oral ulcer.
(6) can carry, not have dangerous, convenient and practical;
(7) production technology is simple, and cost is low.
The specific embodimentBelow in conjunction with embodiment the present invention is done further detailed description:
Be configured according to following table institute column data (percentage by weight %) and affiliated step thereof:
Prescription one:
Former water carries out water treatment through the reverse osmosis water Processing Equipment, carries out according to the following steps behind the heavy metal in the removal water, other harmful substances:
Marine organisms alpha-helix cecropin 6.0-8.0
Cationic polymerization guanidine 0.5
Sargassum polysaccharides analog derivative 0.5-1.0
β-chitosan quaternary ammonium hyaluronic acid analog derivative 1.0-2.0
Enzyme 0.5-1.0
The reverse osmosis pure water adds to 100
Prescription two:
Former water carries out water treatment through the reverse osmosis water Processing Equipment, carries out according to the following steps behind the heavy metal in the removal water, other harmful substances:
Marine organisms alpha-helix cecropin 6.5-8.0
Cationic polymerization guanidine 1.0
Sargassum polysaccharides analog derivative 0.6-1.0
β-chitosan quaternary ammonium hyaluronic acid analog derivative 1.5-2.0
Enzyme 0.6-1.0
The reverse osmosis pure water adds to 100
Prescription three:
Former water carries out water treatment through the reverse osmosis water Processing Equipment, carries out according to the following steps behind the heavy metal in the removal water, other harmful substances:
Marine organisms alpha-helix cecropin 7.0-8.0
Cationic polymerization guanidine 1.5
Sargassum polysaccharides analog derivative 0.7-1.0
β-chitosan quaternary ammonium hyaluronic acid analog derivative 1.7-2.0
Enzyme 0.7-1.0
The reverse osmosis pure water adds to 100.
Claims (2)
1. the present invention relates to a kind of marine organisms degerming oral nursing liquid, (component and percentage by weight % thereof): the β-chitosan quaternary ammonium hyaluronic acid analog derivative 1.0-2.0 that it is characterized in that having following prescription; Sargassum polysaccharides analog derivative 0.5-1.0; Marine organisms alpha-helix cecropin 6.0-8.0; Enzyme 0.5-1.0; Polyhexamethylene guanidine 0.5-1.5 reverse osmosis pure water adds to 100.
2. the method for preparing of said marine organisms degerming oral nursing liquid is characterized in that having following step:
At first, former water is carried out water treatment through the reverse osmosis water Processing Equipment, removes heavy metal, salt and other harmful substances in the water, click step and carry out:
(1) by proportioning said component β-chitosan quaternary ammonium hyaluronic acid analog derivative, Sargassum polysaccharides analog derivative and polyhexamethylene guanidine are added in the aqueous solution, stir;
(2) by proportioning said component marine organisms alpha-helix cecropin is added stirring, mix homogeneously;
(3) add enzyme by proportioning, go the reverse osmosis pure water to add to 100, stir;
(4) detect qualified after, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104234476A CN102525841A (en) | 2011-12-16 | 2011-12-16 | Marine organism bacterium-removal oral care liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104234476A CN102525841A (en) | 2011-12-16 | 2011-12-16 | Marine organism bacterium-removal oral care liquid |
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| Publication Number | Publication Date |
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| CN102525841A true CN102525841A (en) | 2012-07-04 |
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| CN2011104234476A Pending CN102525841A (en) | 2011-12-16 | 2011-12-16 | Marine organism bacterium-removal oral care liquid |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040638A (en) * | 2012-12-07 | 2013-04-17 | 青岛海芬海洋生物科技有限公司 | False tooth nursing liquid containing marine biological sterilization components |
| CN103655306A (en) * | 2013-12-03 | 2014-03-26 | 青岛海芬海洋生物科技有限公司 | Antisepsis and anti-inflammation toothpaste without preservative and preparation method thereof |
| CN103690937A (en) * | 2013-12-02 | 2014-04-02 | 青岛海芬海洋生物科技有限公司 | Children oral decayed-tooth spray containing marine biological ingredients and preparation method thereof |
| CN103858917A (en) * | 2012-12-17 | 2014-06-18 | 青岛海芬海洋生物科技有限公司 | Mildew-resistant liquid used for seeds |
| CN104644481A (en) * | 2013-11-26 | 2015-05-27 | 青岛海芬海洋生物科技有限公司 | Antibacterial cleaning agent for decomposing tooth stains by employing marine biological enzyme |
| CN104644470A (en) * | 2013-11-26 | 2015-05-27 | 青岛海芬海洋生物科技有限公司 | Marine biological enzyme decomposing antibacterial cleaning agent for dental plaque |
| CN107007538A (en) * | 2017-03-03 | 2017-08-04 | 广州薇美姿实业有限公司 | A kind of oral care composition and application containing marine element, and the toothpaste containing marine element |
-
2011
- 2011-12-16 CN CN2011104234476A patent/CN102525841A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040638A (en) * | 2012-12-07 | 2013-04-17 | 青岛海芬海洋生物科技有限公司 | False tooth nursing liquid containing marine biological sterilization components |
| CN103858917A (en) * | 2012-12-17 | 2014-06-18 | 青岛海芬海洋生物科技有限公司 | Mildew-resistant liquid used for seeds |
| CN104644481A (en) * | 2013-11-26 | 2015-05-27 | 青岛海芬海洋生物科技有限公司 | Antibacterial cleaning agent for decomposing tooth stains by employing marine biological enzyme |
| CN104644470A (en) * | 2013-11-26 | 2015-05-27 | 青岛海芬海洋生物科技有限公司 | Marine biological enzyme decomposing antibacterial cleaning agent for dental plaque |
| CN103690937A (en) * | 2013-12-02 | 2014-04-02 | 青岛海芬海洋生物科技有限公司 | Children oral decayed-tooth spray containing marine biological ingredients and preparation method thereof |
| CN103655306A (en) * | 2013-12-03 | 2014-03-26 | 青岛海芬海洋生物科技有限公司 | Antisepsis and anti-inflammation toothpaste without preservative and preparation method thereof |
| CN107007538A (en) * | 2017-03-03 | 2017-08-04 | 广州薇美姿实业有限公司 | A kind of oral care composition and application containing marine element, and the toothpaste containing marine element |
| CN107007538B (en) * | 2017-03-03 | 2020-06-09 | 广州薇美姿实业有限公司 | Oral care composition containing marine elements, application of oral care composition and toothpaste containing marine elements |
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Application publication date: 20120704 |