CN114306149A

CN114306149A - Washing-free antibacterial skin-care disinfecting gel and preparation method thereof

Info

Publication number: CN114306149A
Application number: CN202110996316.0A
Authority: CN
Inventors: 苗保河; 程浩; 赵欣欣; 刘蓉; 欧阳琳
Original assignee: Institute of Urban Agriculture of Chinese Academy of Agricultural Sciences
Current assignee: Institute of Urban Agriculture of Chinese Academy of Agricultural Sciences
Priority date: 2021-08-27
Filing date: 2021-08-27
Publication date: 2022-04-12

Abstract

The invention relates to a washing-free antibacterial skin-care disinfecting gel and a preparation method thereof. The disinfecting gel comprises the following components: a bactericide, a thickener, a plant extract, a surfactant, a polyol, optionally honey, optionally vitamins and water. The preparation method comprises the following steps: providing raw materials according to the requirements of the disinfection gel; adding a thickener to the first portion of water and heating to produce gel A; adding the rest raw materials into the second part of water, and stirring to obtain a base solution B; adding the base solution B into the gel A, and uniformly stirring at the temperature of 30-40 ℃ to obtain the disinfection gel. The disinfection gel disclosed by the invention is fully excavated and combined with the disinfection, sterilization, whitening and skin care effects of the components such as the rose extract, the pomegranate bark extract, the roxburgh rose fruit powder and the honey, and the adopted sterilization components are non-toxic, safe and efficient, and have the characteristics of being quick in washing-free, antibacterial, skin-care, mild, free from hand injury, natural in rose fragrance and the like.

Description

Washing-free antibacterial skin-care disinfecting gel and preparation method thereof

Technical Field

The invention relates to the technical field of daily chemical articles, in particular to a washing-free antibacterial skin-care disinfecting gel and a preparation method thereof.

Background

The hand is the most frequent part of the human body contacting the outside, is very easy to be infected with various pathogenic microorganisms in daily work and life, and is a key measure for preventing viruses when being disinfected.

The current hand washing liquids on the market comprise water-type hand washing liquids, foam hand washing liquids, gel hand washing liquids and the like. The water-based hand sanitizer and the foam hand sanitizer have the defects of easy splashing and dripping, and need to be washed by water, so that the water-based hand sanitizer and the foam hand sanitizer are relatively troublesome and have short effective disinfection time. The gel type hand sanitizer has the advantages of convenience, safety, no washing, practicality, convenience and the like. Chinese patent (CN109646375A) discloses a hand-washing-free disinfection gel and a preparation method thereof, and the gel comprises the following components by weight: 0.1-2 parts of 2,4,4' -trichloro-2-hydroxy-diphenyl ether, 0.1-3 parts of carbomer, 1-100 parts of 75% ethanol, 0.1-5 parts of glycerol, 1-10 parts of plant extracts (tea, sophora flower, honeysuckle flower, bamboo leaf, aloe and orange peel), 0.01-0.5 part of triethanolamine and 1-30 parts of deionized water, and the gel for hand washing-free disinfection can be obtained after 3-72 hours of preparation; chinese patent (CN111214393A) discloses a hand-washing-free disinfection gel, a preparation method and application thereof, wherein the gel comprises the following raw materials in parts by weight: 0.5% of polyhexamethylene guanidine hydrochloride, 50-55% of ethanol, 10% of n-propanol, 2-4% of glycerol, 9400.5% of kappa-formaldehyde, 0.5% of triethanolamine, 0.05% of essence and the balance of purified deionized water, wherein carbomer and other raw materials are dissolved in ethanol when in preparation; chinese patent (CN109771315A) relates to an environment-friendly hand-free disinfection gel, which comprises the following components: the bactericide comprises a bactericide, a thickening agent, polyhydric alcohol with 2-6 carbon atoms, a pH regulator, a loquat extract and water, wherein the thickening agent can be used only after standing for 30-50 hours.

Although the kinds of the disinfecting gel are more, the hand disinfection is emphasized, and the skin care effect is less considered. The common defects of the disinfection gel in the aspect of raw material components are that besides the main disinfection component of alcohol, the disinfection gel is also added with a chemically synthesized bactericide such as triclosan and the like, which pollutes water and has certain toxic effects on human skin, fishes and the like.

Moreover, the above disinfectant gels have the common disadvantages of complicated process, long time consumption, no separation between the disinfectant component preparation and the gel preparation, and inconvenience for practical production in terms of preparation methods, and the preparation time of the disinfectant gel of the present invention can be shortened to within 1 hour.

Disclosure of Invention

In view of the problems in the prior art, the invention provides a no-clean antibacterial skin-care disinfection gel in a first aspect, which comprises the following components: a bactericide, a thickener, a plant extract, a surfactant, a polyol, optionally honey, optionally vitamins and water.

Preferably, the bactericide is ethanol; the thickening agent is carbomer and/or triethanolamine; the plant extract is selected from one or more of rose extract, wild roxburgh rose fruit powder and pomegranate bark extract; the surfactant is a nonionic surfactant; and/or the polyol is selected from one or more of 1, 2-propylene glycol, sorbitol and glycerol.

The present invention provides in a second aspect a method of preparing a sterilising gel according to the first aspect of the invention, the method comprising the steps of:

(1) providing raw materials according to the requirements of the disinfection gel to be prepared;

(2) adding a thickener to the first portion of water and heating to produce gel A;

(3) adding the rest raw materials into the second part of water, and stirring to obtain a base solution B;

(4) adding the base solution B into the gel A, and uniformly stirring at the temperature of 30-40 ℃ to obtain the disinfection gel.

Compared with the prior art, the invention has the following advantages:

(1) the disinfection skin-care gel prepared by the invention has the characteristic of hand washing free, can be dried within 5 s-10s after being kneaded by hands, and does not need hand washing.

(2) The invention does not use chemical synthesis bactericides such as polyhexamethylene guanidine hydrochloride and the like, and the added rose extract hydrosol, pomegranate peel extract, roxburgh rose fruit powder, honey and the like, which are rich in natural substances such as bacteriostasis, sterilization, antivirus and the like, assist hand disinfection, are mild and do not hurt hands.

(3) The above natural components also have antioxidant and antiaging effects, and have good skin caring effect on hand skin.

(4) The disinfecting gel disclosed by the invention has no essence, particularly adopts alpine rose hydrosol, is excellent in quality, not only is rich in citronellol, phenethyl alcohol and other active antibacterial substances, but also has natural rose fragrance and is pleasant.

(5) In the aspect of preparation process, the gel and the disinfection base solution are respectively and independently prepared and are uniformly mixed to obtain the disinfection gel, and compared with other disinfection gels which need to be stood and aged for a long time and are complicated to operate, the disinfection gel is quicker, simpler and easier and is convenient to produce.

Drawings

FIG. 1 shows the packaging (a), the characteristics (b) and the state (c) of the disposable antiseptic skin-care gel prepared in example 1 of the present invention.

Detailed Description

As mentioned above, the invention provides in a first aspect a no-clean antibacterial skin care antiseptic gel, which comprises the following components: a bactericide, a thickener, a plant extract, a surfactant, a polyol, optionally honey, optionally vitamins and water.

In some preferred embodiments, the biocide is ethanol; the thickening agent is carbomer and/or triethanolamine; the plant extract is selected from one or more of rose extract, wild roxburgh rose fruit powder and pomegranate bark extract; the surfactant is a nonionic surfactant; and/or the polyol is selected from one or more of 1, 2-propylene glycol, sorbitol and glycerol.

In other preferred embodiments, the antiseptic gel comprises, by weight in the antiseptic gel:

60% to 70% of a bactericide;

1.2% to 1.8% of a thickener;

9.0% to 9.2% of a plant extract;

1.5% to 2.5% of a surfactant;

2.0% to 2.5% of a polyol;

0 to 4% honey;

0.01 to 0.03% of vitamins; and

and the balance water.

In other preferred embodiments, the thickener is a combination of carbomer 940 and triethanolamine. In some more preferred embodiments, the thickener is carbomer 940 and triethanolamine in a weight ratio of 1: 1 in combination. The inventor finds that the weight ratio of carbomer 940 to triethanolamine is lower than 1: 1, the gel is too viscous and the carbomer is not readily soluble, whereas when the weight ratio is higher than 1: 1, the gel was not easily formed and tended to be watery.

In other preferred embodiments, the plant extract is a combination of rose extract, wild rose fruit powder and pomegranate rind extract.

In other preferred embodiments, the rose extract is a rose hydrosol extracted by steam distillation, and preferably, the rose extract is a rose hydrosol extracted from mountain Miaofeng. Further preferably, the pomegranate bark extract is obtained by extracting pomegranate bark with water.

The rose extract is excellent in quality, rich in natural active antibacterial substances such as citronellol and phenethyl alcohol and remarkable in antibacterial effect. The wild roxburgh rose fruit powder is rich in vitamin C, superoxide dismutase and roxburgh rose flavone, and has good pharmacological effects of resisting oxidation, delaying aging, resisting stress, resisting fatigue, resisting anoxia, inhibiting bacteria, regulating glycolipid metabolism, protecting viscera, regulating digestive system, preventing radiation and the like. The pomegranate peel extract does not contain organic chemical extraction reagents, and the pomegranate peel extract has rich content of active antibacterial ingredients such as punicalagin and the like, and has obvious antibacterial effect on microorganisms and the like.

In other preferred embodiments, the surfactant is coconut diethanolamide. The coconut diethanolamide is selected as the surfactant because the coconut diethanolamide is a nonionic surfactant, has no cloud point, is an amber viscous liquid, has no peculiar smell, is easy to dissolve in water, has good functions of foaming, foam stabilization, penetration decontamination, hard water resistance and the like, has obvious functions of thickening, emulsification and decontamination, and is particularly suitable for preparing transparent products.

In other preferred embodiments, the polyol is a combination of 1, 2-propanediol, sorbitol, and glycerol. The inventor finds that the moisturizing effect of the gel prepared under the composition is particularly remarkable through research.

In other preferred embodiments, the antiseptic gel comprises, in weight percent of the antiseptic gel:

60 to 70% ethanol;

0.7% carbomer 940, 0.7% triethanolamine;

8% of rose extract, 0.1% of wild roxburgh rose fruit powder and 1% of pomegranate bark extract;

2% of coconut diethanolamide;

1% of 1, 2-propylene glycol, 1% of sorbitol and 0.03% of glycerol;

3% of honey;

0.02% vitamin E; and

the balance of water.

In other preferred embodiments, in step (1), the weight percentages of the raw materials of the disinfection gel are as follows: 60-70% of ethanol, 1, 2-propylene glycol, 2% of coconut diethanolamide, 1% of sorbitol, 0.03% of glycerol, 0.02% of vitamin E, 8% of rose extract, 1% of pomegranate peel extract, 0.1% of wild roxburgh rose fruit powder, 3% of honey, 9400.7% of carbomer, 0.7% of triethanolamine and the balance of deionized water.

In some preferred embodiments, the method further comprises step (5) after step (4): and (4) standing the disinfection gel prepared in the step (4) for 0.5 to 1 hour, and then canning and packaging.

The washing-free disinfection skin-care gel provided by the invention takes alcohol as a main disinfection component, is volatile, quick and washing-free, and is convenient to use. In addition, various natural plant components, traditional tonic honey and the like are adopted, the antibacterial and skin-care effects are improved, the natural rose fragrance is mild and does not hurt hands, and the natural rose fragrance can be kept for 6-8 hours.

Examples

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be more clearly and completely described below with reference to the embodiments of the present invention. The described embodiments are, however, a subset of the embodiments of the invention and not all embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.

Example 1:

the amount of antiseptic gel prepared in this example was 1000mL, and the specific composition is shown in Table 1 below.

TABLE 1 materials and amounts used for preparation of antiseptic gels in example 1

The specific operation method comprises the following steps:

(1) adding carbomer 940 into 50mL of deionized water, stirring at 50-60 deg.C, swelling thoroughly to obtain transparent colloid, adding triethanolamine, and stirring to obtain gel A;

(2) dissolving ethanol, 1, 2-propylene glycol, coconut diethanolamide, sorbitol, glycerol, vitamin E, flos Rosae Rugosae extract, pericarpium Granati extract, wild fructus Rosae Normalis powder, and Mel in the rest deionized water, and stirring to obtain base solution B;

(3) adding the base solution B into the gel A, and fully stirring by using a homogenizer at the temperature of 30-40 ℃ to obtain transparent disinfection gel;

(4) after standing for 0.5 hour, canning and packaging are carried out, and the packaged objects are seen in figure 1a (the text in figure 1a can be ignored if the text is unclear). The washing-free disinfection skin-care gel prepared by the embodiment has the characteristics of bacteriostasis, mildness, moistening, fragrance and the like (see figure 1b), and is transparent when extruded from a package (see figure 1 c).

Example 2

The amount of antiseptic gel prepared in this example was 50L, and the specific composition is shown in Table 2 below.

TABLE 2 materials and amounts used for preparation of antiseptic gels in EXAMPLE 2

Name of raw materials	CAS number	Purity of	Rank of	Adding amount of	Percentage of
						Carbomer 940	9007-20-9	99％	Analytical purity	35g	0.7％
Triethanolamine	102-71-6	99％	Analytical purity	35mL	0.7％
						Ethanol	64-17-5	99.7％	Analytical purity	30L	60％
Rose extract	——	——	——	4L	8％
						Pomegranate rind extract	——	——	——	0.5L	1％
Honey	——	——	Food grade	1.5L	3％
						Wild roxburgh rose fruit powder	——	——	Food grade	0.05g	0.1％
Coconut diethanol amine	68603-42-9	100％	Analytical purity	1L	2％
						Sorbitol	——		Analytical purity	0.5L	1％
1, 2-propanediol	57-55-6	99％	Analytical purity	0.5L	1％
						Vitamin E	59-02-9	98％	Analytical purity	10mL	0.02％
Glycerol	——	——	Analytical purity	15mL	0.03％
						Deionized water	——	——	Analytical purity	Make up to 50L	Make up to 100%

The specific operation method comprises the following steps:

(1) adding carbomer 940 into 2.5L deionized water, stirring at 50-60 deg.C, swelling to obtain transparent gel, adding triethanolamine, and stirring to obtain gel A;

(4) standing for 0.5 hr, and canning.

Examples 3 to 7

The procedure was carried out in substantially the same manner as in example 1, except that the components which are not added as indicated in Table 3 below were omitted.

Example 8

This was done in substantially the same manner as in example 1, except that instead of triethanolamine, the combined amount of carbomer 940 and triethanolamine shown in example 1 was used.

Example 9

The procedure was carried out in substantially the same manner as in example 1, except that instead of 1, 2-propanediol, the total amount of sorbitol, 1, 2-propanediol and glycerol shown in example 1 was used.

Sensory evaluation was performed on the finished disinfectant gels obtained in the respective examples, and the results are shown in Table 4 below.

TABLE 4 sensory evaluation of the disinfectant gels obtained in the examples.

As can be seen from the results in the table, the sensory evaluation of the disinfectant gel was greatly influenced by each of the components, and the sensory evaluation of examples 1 and 2 was the most preferable. In addition, tests show that the sterilization gel has a bacteriostasis rate of more than 80 percent on escherichia coli, staphylococcus aureus and the like.

The invention provides a hand-washing-free antibacterial skin-care disinfecting gel, which is prepared from natural active substances such as alcohol, citronellol of rose extract, phenethyl alcohol, polyphenol in pomegranate peel, polyphenol in honey, antibacterial peptide and the like; the skin care component is antioxidant substance in flos Rosae Rugosae hydrosol, fructus Rosae Normalis powder, Mel, etc. The adopted thickener carbomer is non-toxic and non-irritant to skin, and can also protect skin. In addition, the glycerin and the vitamins have the functions of moistening skin and resisting oxidation. The triethanolamine has effects of thickening, keeping moisture, and protecting skin. In addition, the added coconut diethanolamide is an excellent surfactant and can realize the decontamination effect.

The preparation method of the disinfection gel provided by the invention separately prepares the gel A and the base solution B, the base solution B is used for preparing the gel, the amount of the base solution to be added can be determined according to the thickness of the gel, and the production operation is easy.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. The rose washing-free bacteriostatic skin-care disinfecting gel is characterized by comprising the following components: a bactericide, a thickener, a plant extract, a surfactant, a polyol, optionally honey, optionally vitamins and water.

2. The antiseptic gel of claim 1, wherein:

the bactericide is ethanol;

the thickening agent is carbomer and/or triethanolamine;

the plant extract is selected from one or more of rose extract, wild roxburgh rose fruit powder and pomegranate bark extract; the surfactant is a nonionic surfactant; and/or

The polyalcohol is one or more selected from 1, 2-propylene glycol, sorbitol and glycerol.

3. The antiseptic gel of claim 1, wherein the antiseptic gel comprises, by weight in the antiseptic gel:

60% to 70% of a bactericide;

1.2% to 1.8% of a thickener;

9.0% to 9.2% of a plant extract;

1.5% to 2.5% of a surfactant;

2.0% to 2.5% of a polyol;

0 to 4% honey;

0.01 to 0.03% of vitamins; and

and the balance water.

4. The sanitizing gel of claim 1,

the thickener is a combination of carbomer 940 and triethanolamine;

the plant extract is a combination of rose extract, wild roxburgh rose fruit powder and pomegranate rind extract; the surfactant is coconut diethanolamide; and is

The polyol is a combination of 1, 2-propanediol, sorbitol and glycerol.

5. The antiseptic gel of claim 4, wherein said thickening agent is carbomer 940 and triethanolamine in a weight ratio of 1: 1 in combination.

6. The antiseptic gel of claim 5, wherein the antiseptic gel comprises, in weight percent of the antiseptic gel:

60 to 70% ethanol;

0.7% carbomer 940, 0.7% triethanolamine;

2% of coconut diethanolamide;

1% of 1, 2-propylene glycol, 1% of sorbitol and 0.03% of glycerol;

3% of honey;

0.02% vitamin E; and

the balance of water.

7. The antiseptic gel of claim 1, wherein:

the rose extract is rose hydrosol extracted by a steam distillation method;

the pericarpium Granati extract is obtained by extracting pericarpium Granati with water.

8. The antiseptic gel of claim 1, wherein the rose extract is majoram alpine rose hydrosol.

9. A method of preparing a sterilising gel according to any of claims 1 to 8, comprising the steps of:

(4) adding the base solution B into the gel A, and uniformly stirring at the temperature of 30-40 ℃ to obtain a disinfection gel;

preferably, in the step (1), the weight percentages of the raw materials of the disinfection gel are as follows: 60-70% of ethanol, 1, 2-propylene glycol, 2% of coconut diethanolamide, 1% of sorbitol, 0.03% of glycerol, 0.02% of vitamin E, 8% of rose extract, 1% of pomegranate peel extract, 0.1% of wild roxburgh rose fruit powder, 3% of honey, 9400.7% of carbomer, 0.7% of triethanolamine and the balance of deionized water.

10. The method of claim 9, further comprising step (5) after step (4): and (4) standing the disinfection gel prepared in the step (4) for 0.5 to 1 hour, and then canning and packaging.