CN111514098A - Washing-free disinfection gel and preparation method thereof - Google Patents
Washing-free disinfection gel and preparation method thereof Download PDFInfo
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- CN111514098A CN111514098A CN202010435466.XA CN202010435466A CN111514098A CN 111514098 A CN111514098 A CN 111514098A CN 202010435466 A CN202010435466 A CN 202010435466A CN 111514098 A CN111514098 A CN 111514098A
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 238000001879 gelation Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 93
- 239000002562 thickening agent Substances 0.000 claims abstract description 79
- 239000003974 emollient agent Substances 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 238000000227 grinding Methods 0.000 claims abstract description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 229960001631 carbomer Drugs 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 57
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 38
- 229930003427 Vitamin E Natural products 0.000 claims description 19
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 19
- 239000000243 solution Substances 0.000 claims description 19
- 229940046009 vitamin E Drugs 0.000 claims description 19
- 235000019165 vitamin E Nutrition 0.000 claims description 19
- 239000011709 vitamin E Substances 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 18
- 239000011159 matrix material Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 239000011550 stock solution Substances 0.000 claims description 15
- 235000011399 aloe vera Nutrition 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 10
- 238000005187 foaming Methods 0.000 claims description 8
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 7
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 7
- 239000000796 flavoring agent Substances 0.000 claims description 7
- 235000013355 food flavoring agent Nutrition 0.000 claims description 7
- 229920000570 polyether Polymers 0.000 claims description 7
- 230000000249 desinfective effect Effects 0.000 claims description 6
- 235000002961 Aloe barbadensis Nutrition 0.000 claims description 5
- 244000186892 Aloe vera Species 0.000 claims description 5
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 5
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 claims description 3
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 claims description 3
- 229940049638 carbomer homopolymer type c Drugs 0.000 claims description 3
- 229940082484 carbomer-934 Drugs 0.000 claims description 3
- 229940043234 carbomer-940 Drugs 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims 5
- 235000011187 glycerol Nutrition 0.000 claims 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 12
- 230000007794 irritation Effects 0.000 abstract description 10
- 230000001953 sensory effect Effects 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 52
- 241001116389 Aloe Species 0.000 description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
- 239000012141 concentrate Substances 0.000 description 7
- 231100000252 nontoxic Toxicity 0.000 description 7
- 230000003000 nontoxic effect Effects 0.000 description 7
- 239000000645 desinfectant Substances 0.000 description 5
- 238000005070 sampling Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 241000192125 Firmicutes Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 231100000460 acute oral toxicity Toxicity 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 244000060701 Kaempferia pandurata Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 235000016390 Uvaria chamae Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
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- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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Abstract
The invention discloses a washing-free disinfection gel and a preparation method thereof, wherein the washing-free disinfection gel comprises the following components in percentage by mass: 50.3 to 79.5 percent of ethanol, 0.1 to 0.5 percent of thickening agent, 0.2 to 3.5 percent of emollient, 0.1 to 0.5 percent of pH regulator and the balance of water. The ethanol is combined with the thickening agent to form gel, the gel is adjusted to be in a stable state through the pH regulator, and the emollient is added to effectively reduce the irritation of the ethanol to the hand skin. After the thickening agent is foamed, the gel sensory properties after gelling are optimized through a grinding process, and the quality of the gel is improved. After the domestic low-quality carbomer thickener is treated by the process, the gelling effect of the domestic low-quality carbomer thickener is close to or superior to that of the American high-quality carbomer thickener, the production cost of the existing gel is reduced, the dependence on the high-quality carbomer thickener is reduced, and the monopoly of the America on the high-quality carbomer is broken.
Description
Technical Field
The invention belongs to the technical field of disinfection gel, and particularly relates to a washing-free disinfection gel and a preparation method thereof.
Background
At present, when volatile alcohols are used as a disinfectant and a solvent, ethanol or isopropanol is generally used in consideration of the requirements of safety and non-toxicity. Ethanol and isopropanol have a dehydrating effect and can coagulate proteins, resulting in the death of pathogenic bacteria. The ethanol and the isopropanol have particularly remarkable effect of inhibiting the activity of gram negative bacteria, gram positive bacteria, envelope viruses and various fungi in vitro, can kill bacterial propagules, and has stronger killing effect on most lipophilic viruses. Compared with isopropanol, ethanol is more commonly used in the field of hand disinfection, when the content of ethanol is too high, the ethanol has strong pungent smell and is difficult to be accepted by consumers, and when the content of ethanol is too low, the sterilization effect is poor. The optimal ethanol disinfection concentration is 75%. However, ethanol has great irritation to skin, and if an alcohol disinfectant is frequently used for hand washing and disinfection, the skin is dry and rough due to degreasing, so that the ethanol needs to be matched with other components for use.
Under the environment of novel coronary pneumonia and ' epidemic ' of global war ', the health consciousness of national disinfection and sterilization is greatly strengthened, and various hand disinfection products emerge endlessly in the market. With the increasing demand of the market for raw materials, particularly high-quality thickening agents such as carbomer and the like, the price is also the high of the water rising boat. The cost of raw materials is continuously high and rapidly changed, which can be changed three times a day. How to ensure that the product has fine and smooth appearance, no stickiness, comfortable smell and good skin care effect, and can effectively control the production cost becomes a problem to be solved urgently by all manufacturers at present.
Disclosure of Invention
The invention aims to provide a washing-free disinfection gel and a preparation method thereof, aiming at the defects of the prior art, and the washing-free disinfection gel has the advantages of low cost, high quality, good effect, fineness, attractive appearance, fresh hand feeling and small irritation.
The purpose of the invention is realized by the following technical scheme: a washing-free disinfection gel is composed of the following components by mass percent:
50.3 to 79.5 percent of ethanol, 0.1 to 0.5 percent of thickening agent, 0.2 to 3.5 percent of emollient, 0.1 to 0.5 percent of pH regulator, 0.001 to 0.05 percent of flavoring agent and the balance of water.
Further, the thickener is one of carbomer series.
Further, the thickener is one of carbomer 940, carbomer 941, carbomer 934 and carbomer U20.
Further, the emollient is one or more of aloe vera stock solution, glycerol polyether, and vitamin E.
Further, the emollient is a mixture of glycerol and one or two of aloe stock solution, glycerol polyether and vitamin E.
Further, the emollient is a mixture of aloe vera stock solution, vitamin E and glycerol.
Further, the pH regulator is one of triethanolamine and aminomethyl propanol.
A preparation method of a no-clean disinfection gel comprises the following steps:
1) taking the formula amount of water, adding the formula amount of thickening agent for natural foaming until the mixture of the thickening agent and the water becomes transparent, and obtaining thickening agent solution;
2) grinding the thickener solution obtained in the step 1) for 1-20 minutes to obtain uniform and fine thickener concentrate;
3) adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix;
4) adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel, thus obtaining the washing-free disinfection gel.
Further, the grinding in the step 2) is specifically: firstly, utilizing 2500-4000 r/min rotation to grind through three tooth-shaped inclined surface millstones with different degrees of thickness, middle degree and thinness, wherein the thick millstone and the thin millstone rotate clockwise, the middle millstone rotates anticlockwise, and the thickener solution realizes shearing and friction in vibration and vortex by combining different rotation directions of the millstones to obtain primary liquid; and grinding for multiple times according to requirements in a circulating mode to obtain the thickener semen.
The invention has the beneficial effects that: the washing-free disinfection gel uses ethanol as a disinfectant, and the ethanol can inhibit the activity of gram-negative bacteria, gram-positive bacteria, envelope viruses and various fungi and kill bacterial propagules. A small amount of ethanol is attached to the skin, has no toxic or side effect on the human body, cannot cause harm to the body of a user, and is relatively quick in volatilization and not easy to remain on the hands. The hand disinfection gel provided by the invention adopts a grinding process, so that the quality of domestic common carbomer after being gelatinized is effectively improved, and the production cost of raw materials is greatly reduced. The carbomer series is used as a thickening agent to be matched with triethanolamine or aminomethyl propanol to adjust the pH value, so that stable hand disinfection gel can be obtained, the ethanol disinfectant in the hand disinfection gel is distributed uniformly, the hand feeling is fine and smooth, and the sterilization and disinfection effects are improved. The hand disinfection gel provided by the invention has the advantages that the emollient is one or more of aloe stock solution, glycerol polyether and vitamin E, and can relieve the irritation of ethanol to the skin of a human body and play a role in lubrication.
Detailed Description
The following examples further illustrate embodiments of the present invention in detail.
Example 1
The no-clean disinfection gel of the embodiment comprises the following components in percentage by mass:
79.5% of ethanol, 0.1% of thickening agent, 0.2% of emollient, 0.1% of pH regulator, 0.001% of flavoring agent and the balance of water.
The ethanol is edible ethanol with a volume fraction of 95%.
The thickener is carbomer 940.
The pH regulator is aminomethyl propanol.
The emollient is a mixture of vitamin E and glycerol, and the mass ratio of the vitamin E to the glycerol is 1: 40.
The preparation method of the no-clean disinfection gel comprises the following steps:
1) taking the formula amount of water, adding the formula amount of thickening agent for natural foaming until the mixture of the thickening agent and the water becomes transparent, and obtaining thickening agent solution;
2) grinding the thickener solution obtained in the step 1) for 1 minute by a grinder to obtain uniform and fine thickener concentrate;
3) adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix;
4) adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel.
Example 2
The no-clean disinfection gel of the embodiment comprises the following components in percentage by mass:
75% of ethanol, 0.16% of thickening agent, 1.0% of emollient, 0.16% of pH regulator, 0.01% of flavoring agent and the balance of water.
The ethanol is edible ethanol with a volume fraction of 95%.
The thickener is carbomer 941.
The pH regulator is aminomethyl propanol.
The emollient is a mixture of vitamin E and glycerol polyether, and the mass ratio of the vitamin E to the glycerol polyether is 1: 60.
The preparation method of the no-clean disinfection gel comprises the following steps:
1) taking the formula amount of water, adding the formula amount of thickening agent for natural foaming until the mixture of the thickening agent and the water becomes transparent, and obtaining thickening agent solution;
2) grinding the thickener solution obtained in the step 1) for 5 minutes by a grinder to obtain uniform and fine thickener concentrate;
3) adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix;
4) adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel.
Example 3
The no-clean disinfection gel of the embodiment comprises the following components in percentage by mass:
70% of ethanol, 0.25% of thickening agent, 2.0% of emollient, 0.25% of pH regulator, 0.05% of flavoring agent and the balance of water.
The ethanol is edible ethanol with a volume fraction of 95%.
The thickener is carbomer 934.
The pH regulator is triethanolamine.
The emollient is a mixture of aloe stock solution, vitamin E and glycerol, and the mass ratio of the vitamin E to the glycerol is 4:1: 60.
The preparation method of the no-clean disinfection gel comprises the following steps:
1) taking the formula amount of water, adding the formula amount of thickening agent for natural foaming until the mixture of the thickening agent and the water becomes transparent, and obtaining thickening agent solution;
2) grinding the thickener solution obtained in the step 1) for 10 minutes by a grinder to obtain uniform and fine thickener concentrate;
3) adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix;
4) adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel.
Example 4
The no-clean disinfection gel of the embodiment comprises the following components in percentage by mass:
65% of ethanol, 0.5% of thickening agent, 3.0% of emollient, 0.5% of pH regulator, 0.02% of flavoring agent and the balance of water.
The ethanol is edible ethanol with a volume fraction of 95%.
The thickener is carbomer U20.
The pH regulator is triethanolamine.
The emollient is a mixture of aloe stock solution, vitamin E and glycerol, and the mass ratio of the aloe stock solution to the vitamin E to the glycerol is 4:1: 60.
The preparation method of the no-clean disinfection gel comprises the following steps:
1) taking the formula amount of water, adding the formula amount of thickening agent for natural foaming until the mixture of the thickening agent and the water becomes transparent, and obtaining thickening agent solution;
2) grinding the thickener solution obtained in the step 1) for 1-20 minutes by using a grinder to obtain uniform and fine thickener concentrate;
3) adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix;
4) adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel.
Example 5
The no-clean disinfection gel of the embodiment comprises the following components in percentage by mass:
50.3% of ethanol, 0.3% of thickening agent, 3.5% of emollient, 0.3% of pH regulator, 0.03% of flavoring agent and the balance of water.
The ethanol is edible ethanol with a volume fraction of 95%.
The thickener is carbomer U20.
The pH regulator is triethanolamine.
The emollient is a mixture of aloe stock solution, vitamin E and glycerol, and the mass ratio of the aloe stock solution to the vitamin E to the glycerol is 4:1: 80.
The preparation method of the no-clean disinfection gel comprises the following steps:
1) taking the formula amount of water, adding the formula amount of thickening agent for natural foaming until the mixture of the thickening agent and the water becomes transparent, and obtaining thickening agent solution;
2) grinding the thickener solution obtained in the step 1) for 15 minutes by a grinder to obtain uniform and fine thickener concentrate;
3) adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix;
4) adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel.
Example 6
The no-clean disinfection gel of the embodiment comprises the following components in percentage by mass:
75% of ethanol, 0.275% of thickening agent, 2.525% of emollient, 0.3% of pH regulator and the balance of water.
The ethanol is edible ethanol with a volume fraction of 95%.
The thickener is carbomer U20.
The pH regulator is triethanolamine.
The emollient is a mixture of aloe stock solution, vitamin E and glycerol, and the mass ratio of the aloe stock solution to the vitamin E to the glycerol is 4:1: 80.
The preparation method of the no-clean disinfection gel comprises the following steps:
1) taking the formula amount of water, adding the formula amount of thickening agent for natural foaming until the mixture of the thickening agent and the water becomes transparent, and obtaining thickening agent solution;
2) grinding the thickener solution obtained in the step 1) for 20 minutes by a grinder to obtain uniform and fine thickener concentrate;
3) adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix;
4) adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel.
One-time, no-clean disinfection gel bacteriostasis effect test
Experimental methods
A suspension quantitative method is adopted, and the 'disinfection technical specification' is referred to in 2002 edition. The hand-free disinfection gel stock solution is used for treating staphylococcus aureus, escherichia coli, candida albicans and poliovirus at 20 ℃ for 0.5min, and the test is repeated for three times.
Hand disinfection field test the hand disinfection field test was performed according to article 2.1.2.6 disinfectant in the 2002 edition of disinfection technical Specification. Before disinfection, the two hands of a testee are rubbed fully, the left fingers of the testee are closed, a sterile cotton swab is soaked in a test tube containing 10mL of diluent, the test tube is wrung on the tube wall, the two times of rubbing are carried out on the bent fingertips of the five fingers to the finger roots, and the cotton swab is rotated once each time. After sampling, the sampling end of the cotton swab was cut into a diluent tube in a sterile manner to serve as a positive control sample. And then, disinfecting the right hand for 1min by adopting the hand-washing-free disinfection gel, replacing the diluent with a neutralization solution after disinfection, and sampling the natural bacteria remained on the right hand of the subject once by the same method as the positive control group to be used as a sample of the experimental group. After sampling, the culture was carried out at 37 ℃ for 48 hours to observe the final results.
TABLE 1 average log kill of microorganisms
As can be seen from the results in Table 1, the no-clean disinfection gel prepared by the invention has good effect of killing microorganisms.
Two or more skin irritation tests
Skin irritation tests were performed according to the "Disinfection Specification" 2002 edition, item 2.3.3, with the following test results:
TABLE 2 results of multiple skin irritation tests
| Item | Composite score | Strength grade |
| Example 1 | 0 | Has no irritation |
| Example 2 | 0.2 | Has no irritation |
| Example 3 | 0 | Has no irritation |
| Example 4 | 0.2 | Has no irritation |
| Example 5 | 0 | Has no irritation |
| Example 6 | 0 | Has no irritation |
As can be seen from the results in Table 2, the no-clean disinfecting gel of the embodiments 1 to 6 of the invention is mild and non-irritant to the skin and safe to use.
Third, acute oral toxicity test
The test is carried out according to the technical Specification for disinfection (2002 edition), and the test results are as follows:
TABLE 3 acute oral toxicity test results
| Item | LD50Measurement of | Grade of toxicity |
| Example 1 | LD50>5000mg/kg | Is practically nontoxic |
| Example 2 | LD50>5000mg/kg | Is practically nontoxic |
| Example 3 | LD50>5000mg/kg | Is practically nontoxic |
| Example 4 | LD50>5000mg/kg | Is practically nontoxic |
| Example 5 | LD50>5000mg/kg | Is practically nontoxic |
| Example 6 | LD50>5000mg/kg | Is practically nontoxic |
As can be seen from the results in Table 3, the no-clean disinfecting gels of examples 1-6 of the present invention are of practical non-toxic grade.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. The invention is limited only by the claims and their full scope and equivalents.
Claims (9)
1. The washing-free disinfection gel is characterized by comprising the following components in percentage by mass:
50.3 to 79.5 percent of ethanol, 0.1 to 0.5 percent of thickening agent, 0.2 to 3.5 percent of emollient, 0.1 to 0.5 percent of pH regulator, 0.001 to 0.05 percent of flavoring agent and the balance of water.
2. The leave-on disinfecting gel of claim 1, wherein the thickening agent is one of the carbomer series.
3. The leave-in antiseptic gel of claim 2 wherein the thickening agent is one of carbomer 940, carbomer 941, carbomer 934, carbomer U20.
4. The leave-on antiseptic gel of claim 1, wherein the emollient is one or more of aloe vera stock solution, glycerin, glyceryl polyether, vitamin E.
5. The leave-on antiseptic gel of claim 4 wherein the emollient is a mixture of one or two of aloe vera stock solution, glyceryl polyether, vitamin E and glycerin.
6. The leave-on antiseptic gel of claim 5 wherein the emollient is a mixture of aloe vera stock solution, vitamin E and glycerin.
7. The no-clean disinfecting gel of claim 1, wherein the pH regulator is one of triethanolamine and aminomethyl propanol.
8. A method of making a leave-on antiseptic gel as recited in claim 1, comprising the steps of:
1) and taking the formula water, adding the formula amount of thickening agent, and naturally foaming until the mixture of the thickening agent and the water becomes transparent to obtain a thickening agent solution.
2) Grinding the thickener solution obtained in the step 1) for 1-20 minutes to obtain uniform and fine thickener semen.
3) Adding ethanol and an emollient in a formula amount into the thickener essence liquid in the step 2), and stirring to obtain a basic gel matrix.
4) Adding a pH regulator with the formula amount into the basic gel matrix in the step 3), and uniformly stirring to prepare gel, thus obtaining the washing-free disinfection gel.
9. The method for preparing a no-clean disinfecting gel according to claim 8, wherein the grinding in step 2) is specifically: firstly, utilizing 2500-4000 r/min rotation to grind by three tooth-shaped inclined surface grinding discs with different degrees of thickness, middle thickness and thinness. The thickening agent solution is sheared and rubbed in vibration and vortex by clockwise rotation of the coarse grinding disc and the fine grinding disc and anticlockwise rotation of the middle grinding disc in combination with different rotation directions of the grinding discs to obtain primary liquid; and grinding for multiple times according to requirements in a circulating mode to obtain the thickener semen.
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| CN112156060A (en) * | 2020-11-12 | 2021-01-01 | 云南润嘉药业有限公司 | Propolis wash-free long-acting antibacterial gel and preparation method thereof |
| CN112370394A (en) * | 2020-12-10 | 2021-02-19 | 青岛格林维尔环保技术有限公司 | Hydrogen-rich water-containing hand-washing-free disinfection gel and preparation method thereof |
| CN112536142A (en) * | 2020-11-17 | 2021-03-23 | 中溶科技股份有限公司 | Colloid mill device and process for producing hand-free disinfection gel by adopting same |
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| CN114306149A (en) * | 2021-08-27 | 2022-04-12 | 中国农业科学院都市农业研究所 | Washing-free antibacterial skin-care disinfecting gel and preparation method thereof |
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| CN111973535A (en) * | 2020-09-10 | 2020-11-24 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Folium artemisiae argyi washing-free disinfection gel and preparation method thereof |
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| CN112156060A (en) * | 2020-11-12 | 2021-01-01 | 云南润嘉药业有限公司 | Propolis wash-free long-acting antibacterial gel and preparation method thereof |
| CN112536142A (en) * | 2020-11-17 | 2021-03-23 | 中溶科技股份有限公司 | Colloid mill device and process for producing hand-free disinfection gel by adopting same |
| CN112370394A (en) * | 2020-12-10 | 2021-02-19 | 青岛格林维尔环保技术有限公司 | Hydrogen-rich water-containing hand-washing-free disinfection gel and preparation method thereof |
| CN113456530A (en) * | 2021-05-17 | 2021-10-01 | 江苏敖广日化集团股份有限公司 | High-concentration washing-free disinfection gel and preparation method thereof |
| CN114306149A (en) * | 2021-08-27 | 2022-04-12 | 中国农业科学院都市农业研究所 | Washing-free antibacterial skin-care disinfecting gel and preparation method thereof |
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