CN105030661A - Disinfection gel and preparing method of disinfection gel - Google Patents
Disinfection gel and preparing method of disinfection gel Download PDFInfo
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- CN105030661A CN105030661A CN201510501167.0A CN201510501167A CN105030661A CN 105030661 A CN105030661 A CN 105030661A CN 201510501167 A CN201510501167 A CN 201510501167A CN 105030661 A CN105030661 A CN 105030661A
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Abstract
The invention relates to disinfection gel and a preparing method of the disinfection gel. The disinfection gel is prepared from the following ingredients in percentage by mass: 0.05 to 0.2 percent of benzethonium chloride, 30 to 80 percent of ethanol, 0.1 to 1 percent of thickening agents, 3.0 to 8.0 percent of humectants, 0.1 to 1 percent of PH regulators and the balance deionized water. The disinfection gel provided by the invention uses the benzethonium chloride and the ethanol as clean anti-corrosion bactericide, and the effects of fast sterilization and permanent sterilization and bacteriostasis are achieved. The thickening agents, the humectants and the PH regulators are added, so that good gel performance is realized. Compared with the prior art, the disinfection gel has the advantages that the recipe is reasonable; the performance is stable; the use is convenient; the hand feeling is good; a good sterilization effect is achieved; the injury to the skin is avoided; no potential health risk exists; the disinfection gel is particularly applicable to medical aspect hand washing and hand wiping sterilization work.
Description
Technical field
The application relates to disinfecting field, is specifically related to a kind of disinfecting gel and preparation method thereof.
Background technology
At present, the hospital infection problem become increasingly conspicuous, has become the public health problem that hospital is badly in need of solving.U.S. CDC (Disease Control and Prevention Center) research shows: the nosocomial infection of 80% propagates between patient because of hands.By strengthening the hospital infection that hand hygiene can reduce by 1/3, and to wash one's hands be reduce most economical, the most effective method of hospital infection, and washing one's hands also is the most effective method of medical personnel's self-protection.Although hospital has relevant specification strict regulations to wash one's hands this process, at present the implementation dynamics of this specification is allowed of no optimist.Show according to epidemiological survey result: the medical personnel with about 40% to 50% are engaged in curative activity when not washing one's hands.The main cause producing this result is, medical worker's inconvenience in various operating process is washed one's hands or washed one's hands and does as a mere formality, and worries in addition frequently wash one's hands and sterilize skin generation stimulation or cause xerosis cutis.Therefore, there is most people and consciously can not carry out handwashing disinfection before being engaged in curative activity.
Large quantifier elimination and investigation confirm, washing one's hands is the main path that can cut off nosocomial spread, are that to reduce hospital infection most economical, most effective method.Disinfecting gel has the features such as Non-water washing, rapid-curing cutback, quick-acting, holding effect, has been widely used in health hand-wrist bones and surgery hand-wrist bones.
Disinfecting gel in the market mainly contains two classes:
One class is with the antibacterial of the aniones such as triclosan, the product being thickening agent with card ripple, but this product exists potential health risk to user.
Another kind of is with cationes such as chlorhexidine gluconates for antibacterial, the gel products being thickening agent with hydroxypropyl emthylcellulose or carboxymethyl cellulose, and this series products exists the problems such as feel is sticky because of the reason of thickening agent.In addition, the valid density that this product is conventional is 0.5%-4%, and consumption is large, and product cost is high.
Summary of the invention
The application provides a kind of disinfecting gel and preparation method thereof, solves disinfecting gel use inconvenience in prior art, feel is poor, bactericidal effect is poor, injure skin, have the problems such as health risk.
According to the first aspect of the application, this application provides a kind of disinfecting gel, be made up of the raw material of following mass percent: benzethonium chloride 0.05-0.2%, ethanol 30-80%, thickening agent 0.1-1%, wetting agent 3.0-8.0%, PH regulator 0.1-1%, surplus is deionized water.
In one embodiment, described thickening agent is carbomer.
In one embodiment, described wetting agent is any one or two kinds in glycerol and propylene glycol.
In one embodiment, described PH regulator is triethanolamine or isobutyl hydramine.
Preferably, described disinfecting gel also comprises: vitamin E 0.1-1%, and essence 0.05-0.2%.
In one embodiment, described disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.1%, ethanol 70%, carbomer 0.3%, propylene glycol 3%, triethanolamine 0.3%, vitamin E 0.5%, essence 0.1%, and surplus is deionized water.
According to the second aspect of the application, this application provides a kind of preparation method of any one disinfecting gel above-mentioned, comprising:
Take thickening agent, added in deionized water swelling;
Take benzethonium chloride, be dissolved in alcoholic solution, stir;
Take wetting agent, added in alcoholic solution; Afterwards, then add swelling good thickening agent; After stirring, then add PH regulator, to form gel; Finally, then add the benzethonium chloride dissolved, be sterilized after stirring gel.
Preferably, when wetting agent is added in alcoholic solution, also the vitamin E taken is added in alcoholic solution together; After adding the benzethonium chloride dissolved, also comprise the step adding essence.
Disinfecting gel that the application provides and preparation method thereof, disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.05-0.2%, ethanol 30-80%, thickening agent 0.1-1%, wetting agent 3.0-8.0%, PH regulator 0.1-1%, surplus is deionized water.The disinfecting gel that the application provides, using benzethonium chloride and ethanol as clean anticorrosion and bactericidal agent, plays the effect of quick sterilization and permanent bactericidal.By adding thickening agent, wetting agent and Ph regulator, there is good gelling performance.Compared with prior art, its formula is reasonable, stable performance, and easy to use, soft handle, has the effect of good sterilization, and do not injure skin, without health risk, is specially adapted to the washing one's hands of medical aspect, wipes hand-wrist bones work.
Accompanying drawing explanation
Fig. 1 is the preparation method flow chart of disinfecting gel in a kind of embodiment of the application;
Fig. 2 is the preparation method flow chart of disinfecting gel in the another kind of embodiment of the application.
Detailed description of the invention
The disinfecting gel that the embodiment of the present application provides, using benzethonium chloride and ethanol as clean anticorrosion and bactericidal agent, plays the effect of quick sterilization and permanent bactericidal.By adding thickening agent, wetting agent and Ph regulator, there is good gelling performance.Compared with prior art, its formula is reasonable, stable performance, and easy to use, soft handle, has the effect of good sterilization, and do not injure skin, without health risk, is specially adapted to the washing one's hands of medical aspect, wipes hand-wrist bones work.
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.05-0.2%, ethanol 30-80%, thickening agent 0.1-1%, and wetting agent 3.0-8.0%, PH regulator 0.1-1%, surplus is deionized water.
Concrete, thickening agent is carbomer, such as carbomer U2O.Wetting agent is any one or two kinds in glycerol and propylene glycol.PH regulator is triethanolamine or isobutyl hydramine.
Preferably, in further embodiments, disinfecting gel also comprises: vitamin E 0.1-1%, and essence 0.05-0.2%.Thus improve the skin effect of disinfecting gel, and eliminate the penetrating odor of disinfecting gel.
Please refer to Fig. 1, be the preparation method schematic flow sheet of disinfecting gel, the method comprises step below:
Step 1.1: take thickening agent, is added in deionized water swelling.
Step 1.2: take benzethonium chloride, is dissolved in alcoholic solution, is stirred.It should be noted that, the solvent of the alcoholic solution that the embodiment of the present application is mentioned is deionized water.
Step 1.3: take wetting agent, is added in alcoholic solution.
Step 1.4: add swelling good thickening agent in the solution obtained in step 1.3.
Step 1.5: after stirring, then add PH regulator, to form gel.
Step 1.6: add the benzethonium chloride dissolved, be sterilized after stirring gel.
Preferably, please refer to Fig. 2, in other embodiments, the preparation method schematic flow sheet of disinfecting gel, the method comprises step below:
Step 2.1: take thickening agent, is added in deionized water swelling.
Step 2.2: take benzethonium chloride, is dissolved in alcoholic solution, is stirred.It should be noted that, the solvent of the alcoholic solution that the embodiment of the present application is mentioned is deionized water.
Step 2.3: take wetting agent and vitamin E, added in alcoholic solution.
Step 2.4: add swelling good thickening agent in the solution obtained in step 2.3.
Step 2.5: after stirring, then add PH regulator, to form gel.
Step 2.6: add the benzethonium chloride dissolved, stirs.
Step 2.7: add essence, be sterilized after stirring gel.
By reference to the accompanying drawings the application is described in further detail below by detailed description of the invention.
Embodiment one:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.05%, ethanol 30%, carbomer 0.1%, glycerol 3% (or propylene glycol 3%, or the mixed liquor 3% of glycerol and propylene glycol), triethanolamine 0.1% (or isobutyl hydramine 0.1%), surplus is deionized water.
Embodiment two:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.1%, ethanol 60%, carbomer 0.6%, glycerol 5% (or propylene glycol 5%, or the mixed liquor 5% of glycerol and propylene glycol), triethanolamine 0.6% (or isobutyl hydramine 0.6%), surplus is deionized water.
Embodiment three:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.2%, ethanol 80%, carbomer 1%, glycerol 8% (or propylene glycol 8%, or the mixed liquor 8% of glycerol and propylene glycol), triethanolamine 1% (or isobutyl hydramine 1%), surplus is deionized water.
Embodiment four:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.1%, ethanol 70%, carbomer 0.3%, glycerol 3% (or propylene glycol 3%, or the mixed liquor 3% of glycerol and propylene glycol), triethanolamine 0.3% (or isobutyl hydramine 0.3%), surplus is deionized water.
Embodiment five:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.05%, ethanol 30%, carbomer 0.1%, glycerol 3% (or propylene glycol 3%, or the mixed liquor 3% of glycerol and propylene glycol), triethanolamine 0.1% (or isobutyl hydramine 0.1%), vitamin E 0.1%, essence 0.05%, surplus is deionized water.
Embodiment six:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.1%, ethanol 60%, carbomer 0.6%, glycerol 5% (or propylene glycol 5%, or the mixed liquor 5% of glycerol and propylene glycol), triethanolamine 0.6% (or isobutyl hydramine 0.6%), vitamin E 0.5%, essence 0.1%, surplus is deionized water.
Embodiment seven:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.2%, ethanol 80%, carbomer 1%, glycerol 8% (or propylene glycol 8%, or the mixed liquor 8% of glycerol and propylene glycol), triethanolamine 1% (or isobutyl hydramine 1%), vitamin e1 %, essence 0.2%, surplus is deionized water.
Embodiment eight:
Disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.1%, ethanol 70%, carbomer 0.3%, glycerol 3% (or propylene glycol 3%, or the mixed liquor 3% of glycerol and propylene glycol), triethanolamine 0.3% (or isobutyl hydramine 0.3%), vitamin E 0.5%, essence 0.1%, surplus is deionized water.
In other embodiments, can according to the actual requirements, within the scope of the mass percent of each raw material provided in the application, the ratio of each raw material of unrestricted choice.
Above content is the further description done the application in conjunction with concrete embodiment, can not assert that the concrete enforcement of the application is confined to these explanations.For the application person of an ordinary skill in the technical field, under the prerequisite not departing from the present application design, some simple deduction or replace can also be made.
Claims (8)
1. a disinfecting gel, is characterized in that, is made up of the raw material of following mass percent: benzethonium chloride 0.05-0.2%, ethanol 30-80%, thickening agent 0.1-1%, and wetting agent 3.0-8.0%, PH regulator 0.1-1%, surplus is deionized water.
2. disinfecting gel as claimed in claim 1, it is characterized in that, described thickening agent is carbomer.
3. disinfecting gel as claimed in claim 1, is characterized in that, described wetting agent is any one or two kinds in glycerol and propylene glycol.
4. disinfecting gel as claimed in claim 2, it is characterized in that, described PH regulator is triethanolamine or isobutyl hydramine.
5. the disinfecting gel according to any one of Claims 1-4, is characterized in that, also comprises: vitamin E 0.1-1%, and essence 0.05-0.2%.
6. disinfecting gel as claimed in claim 5, it is characterized in that, described disinfecting gel is made up of the raw material of following mass percent: benzethonium chloride 0.1%, ethanol 70%, carbomer 0.3%, propylene glycol 3%, triethanolamine 0.3%, vitamin E 0.5%, essence 0.1%, surplus is deionized water.
7. as required a preparation method for disinfecting gel as described in any one of 1-6, it is characterized in that, comprising:
Take thickening agent, added in deionized water swelling;
Take benzethonium chloride, be dissolved in alcoholic solution, stir;
Take wetting agent, added in alcoholic solution; Afterwards, then add swelling good thickening agent; After stirring, then add PH regulator, to form gel; Finally, then add the benzethonium chloride dissolved, be sterilized after stirring gel.
8. method as claimed in claim 7, is characterized in that, when being added in alcoholic solution by wetting agent, also added together in alcoholic solution by the vitamin E taken; After adding the benzethonium chloride dissolved, also comprise the step adding essence.
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362212A (en) * | 2015-12-18 | 2016-03-02 | 南京巨鲨显示科技有限公司 | Washing-free sterilizing gel and preparing method thereof |
| CN105963147A (en) * | 2016-06-20 | 2016-09-28 | 南京巨鲨显示科技有限公司 | Hand-washing-free lipidosome disinfecting gel and preparation method thereof |
| CN106166117A (en) * | 2016-07-06 | 2016-11-30 | 湖北洁之梦生物科技有限公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN106237348A (en) * | 2016-08-18 | 2016-12-21 | 南京巨鲨显示科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN107041849A (en) * | 2017-04-11 | 2017-08-15 | 稳健医疗用品股份有限公司 | A kind of medical disinfecting emulsion and its preparation method and application |
| CN107158273A (en) * | 2017-06-08 | 2017-09-15 | 苏州凌科特新材料有限公司 | Medical disinfection gel and preparation method thereof |
| CN109536132A (en) * | 2018-11-27 | 2019-03-29 | 南通优护优家卫生用品有限公司 | It can be applied to the thickener of cationic sterilised products |
| CN111388341A (en) * | 2020-03-27 | 2020-07-10 | 深圳市小雨健生科技有限公司 | Washing-free hand protection disinfectant and preparation method thereof |
| CN111467283A (en) * | 2020-04-23 | 2020-07-31 | 济宁百世微生物技术有限公司 | Disinfectant gel and preparation method thereof |
| CN111803390A (en) * | 2020-07-27 | 2020-10-23 | 广群化妆品科学技术研究院(广州)有限公司 | Hypochlorous acid water nanogel and preparation method thereof |
| CN112370439A (en) * | 2020-07-22 | 2021-02-19 | 浙江嘉富力环保科技有限公司 | Preparation method of disinfectant |
| CN112587421A (en) * | 2021-01-09 | 2021-04-02 | 合肥贝壳派创新科技有限公司 | Washing-free hand disinfection gel containing plant extracts and preparation method and application thereof |
| CN113288860A (en) * | 2021-03-11 | 2021-08-24 | 江西车仆实业有限公司 | Convenient and easy-to-produce hand-washing-free disinfection gel and preparation method thereof |
| CN115212137A (en) * | 2022-08-01 | 2022-10-21 | 南京中敖日化科技有限公司 | Alcohol disinfection gel aerosol and preparation method thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362212A (en) * | 2015-12-18 | 2016-03-02 | 南京巨鲨显示科技有限公司 | Washing-free sterilizing gel and preparing method thereof |
| CN105963147A (en) * | 2016-06-20 | 2016-09-28 | 南京巨鲨显示科技有限公司 | Hand-washing-free lipidosome disinfecting gel and preparation method thereof |
| CN106166117A (en) * | 2016-07-06 | 2016-11-30 | 湖北洁之梦生物科技有限公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN106237348A (en) * | 2016-08-18 | 2016-12-21 | 南京巨鲨显示科技有限公司 | A kind of medical ultrasonic coupling agent and preparation method thereof |
| CN107041849A (en) * | 2017-04-11 | 2017-08-15 | 稳健医疗用品股份有限公司 | A kind of medical disinfecting emulsion and its preparation method and application |
| CN107158273A (en) * | 2017-06-08 | 2017-09-15 | 苏州凌科特新材料有限公司 | Medical disinfection gel and preparation method thereof |
| CN109536132A (en) * | 2018-11-27 | 2019-03-29 | 南通优护优家卫生用品有限公司 | It can be applied to the thickener of cationic sterilised products |
| CN111388341A (en) * | 2020-03-27 | 2020-07-10 | 深圳市小雨健生科技有限公司 | Washing-free hand protection disinfectant and preparation method thereof |
| CN111467283A (en) * | 2020-04-23 | 2020-07-31 | 济宁百世微生物技术有限公司 | Disinfectant gel and preparation method thereof |
| CN112370439A (en) * | 2020-07-22 | 2021-02-19 | 浙江嘉富力环保科技有限公司 | Preparation method of disinfectant |
| CN111803390A (en) * | 2020-07-27 | 2020-10-23 | 广群化妆品科学技术研究院(广州)有限公司 | Hypochlorous acid water nanogel and preparation method thereof |
| CN112587421A (en) * | 2021-01-09 | 2021-04-02 | 合肥贝壳派创新科技有限公司 | Washing-free hand disinfection gel containing plant extracts and preparation method and application thereof |
| CN113288860A (en) * | 2021-03-11 | 2021-08-24 | 江西车仆实业有限公司 | Convenient and easy-to-produce hand-washing-free disinfection gel and preparation method thereof |
| CN115212137A (en) * | 2022-08-01 | 2022-10-21 | 南京中敖日化科技有限公司 | Alcohol disinfection gel aerosol and preparation method thereof |
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