CN115212137A - Alcohol disinfection gel aerosol and preparation method thereof - Google Patents
Alcohol disinfection gel aerosol and preparation method thereof Download PDFInfo
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- CN115212137A CN115212137A CN202210914912.4A CN202210914912A CN115212137A CN 115212137 A CN115212137 A CN 115212137A CN 202210914912 A CN202210914912 A CN 202210914912A CN 115212137 A CN115212137 A CN 115212137A
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 239000000443 aerosol Substances 0.000 title claims abstract description 37
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title description 10
- 238000001856 aerosol method Methods 0.000 title description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 27
- 229960001631 carbomer Drugs 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000001335 aliphatic alkanes Chemical class 0.000 claims abstract description 12
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 12
- 239000004088 foaming agent Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000003380 propellant Substances 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 230000003472 neutralizing effect Effects 0.000 claims abstract description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 25
- 238000011049 filling Methods 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 12
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical group CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 230000002421 anti-septic effect Effects 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 229940085237 carbomer-980 Drugs 0.000 claims description 5
- 230000000249 desinfective effect Effects 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 3
- 229940049638 carbomer homopolymer type c Drugs 0.000 claims description 3
- 229940043234 carbomer-940 Drugs 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000007789 sealing Methods 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 125000005250 alkyl acrylate group Chemical group 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 244000178870 Lavandula angustifolia Species 0.000 description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000018219 lavender Nutrition 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011265 semifinished product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 241001052560 Thallis Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 229940075894 denatured ethanol Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides an alcohol disinfection gel aerosol, which comprises disinfection gel and a propellant in an aerosol bottle, wherein the disinfection gel comprises, by mass, 58-63 parts of alcohol, 37-42 parts of deionized water, 5-8 parts of low-boiling-point alkane, 0.5-1 part of carbomer, 0.5-1 part of foaming agent, 0.5-1 part of neutralizing agent, 1-3 parts of humectant and 0.5-1 part of essence. The invention greatly improves the sealing performance by adopting the originally packaged aerosol package, effectively prolongs the quality guarantee period of the product and is more convenient in the use process; the special button for the gel can be used, the gel is convenient to use, is fully used without waste, has a good sterilization effect and is convenient to use, and the gel can be added with a humectant to prevent hands from being dry.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to an alcohol disinfection gel aerosol and a preparation method thereof.
Background
Sanitary disinfection is an indispensable link of life, and especially hand disinfection is especially crucial, wears the gauze mask, it is hard to wash hands, keep social distance to become everyone's custom, but not all have water to wash hands at every moment, and the water-free hand lotion becomes especially important, but the unwashed hand lotion on the market all is the plastic bottle packing, has the risk of leaking in the use, and the leakproofness of plastic bottle is not high, and alcohols volatilize very easily in addition, cause active ingredient easily to reduce serious influence effect and use validity period. The aerosol is convenient to use, good in sealing performance, and capable of effectively solving the defects of common aerosols due to the innovative packaging mode of binary packaging.
Therefore, the development of an alcohol disinfectant gel aerosol is an urgent need in the market.
Disclosure of Invention
The invention aims to solve the technical problems in the prior art, and provides an alcohol disinfection gel aerosol and a preparation method thereof, so as to solve the technical problems in the background technology.
In order to solve the technical problems, the invention adopts the technical scheme that: the alcohol disinfection gel aerosol comprises disinfection gel and a propellant which are positioned in an aerosol bottle, wherein the disinfection gel comprises, by mass, 58-63 parts of alcohol, 37-42 parts of deionized water, 5-8 parts of low-boiling-point alkane, 0.5-1 part of carbomer, 0.5-1 part of foaming agent, 0.5-1 part of neutralizer, 1-3 parts of humectant and 0.5-1 part of essence.
Further, the propellant is compressed air, and the mass portion of the compressed air is 0.2-0.4.
Further, the alcohol is any one of ethanol and isopropanol.
Further, the carbomer comprises one or more combinations of carbomer u20, carbomer u22, carbomer 940 and carbomer 980.
Further, the foaming agent is one or more of APG1080 or LS-30.
Further, the neutralizing agent is one or two of triethanolamine, sodium hydroxide solution, potassium hydroxide solution and aminomethyl propanol.
Further, the humectant is one or the combination of two of glycerin and propylene glycol.
Further, the low boiling alkane is pentane.
Further, a method for preparing an alcohol based disinfecting gel aerosol as claimed in any one of claims 1 to 8, comprising the steps of:
s1, adding carbomer into deionized water and stirring until the carbomer is completely swelled;
s2, adding alcohol, a humectant, a foaming agent and essence into the mixed solution obtained in the S1, stirring for 15min, and adjusting to be neutral;
and S3, filling the feed liquid obtained in the S2 and the compressed air by a binary aerosol filling method, and then additionally injecting low-boiling-point alkane.
Compared with the prior art, the invention has the beneficial effects that:
1) The aerosol package of the original package greatly improves the sealing performance, effectively prolongs the quality guarantee period of the product and is more convenient in the use process;
2) The special button for the gel can be used, the gel is convenient to use, is fully used without waste, has a good sterilization effect and is convenient to use, and the gel can be added with a humectant to prevent hands from being dry.
Detailed Description
It is easily understood that according to the technical solution of the present invention, a person skilled in the art can propose various alternative structures and implementation ways without changing the spirit of the present invention. Therefore, the following detailed description and the accompanying drawings are merely illustrative of the technical aspects of the present invention, and should not be construed as all of the present invention or as limitations or limitations on the technical aspects of the present invention.
An alcohol disinfection gel aerosol is prepared by a binary aerosol preparation method and comprises feed liquid and a propellant, wherein the feed liquid comprises, by mass, 58-63 parts of deionized water, 37-42 parts of deionized water, 0.5-1 part of carbomer, 0.5-1 part of a foaming agent, 0.5-1 part of a neutralizing agent, 1-3 parts of a humectant, 0.5-1 part of essence, 0.2-0.4 part of compressed air serving as the propellant, and 5-8 parts of low-boiling-point alkane serving as the propellant.
The alcohol is any one of ethanol and isopropanol; the low-boiling-point alkane is pentane, and the carbomer is one or a combination of carbomer U20, carbomer U22, carbomer 940 and carbomer 980; the foaming agent is one or more of APG1080 or LS-30; the neutralizer is one or two of triethanolamine, sodium hydroxide solution, potassium hydroxide solution and aminomethyl propanol; the humectant is one or two of glycerol and propylene glycol.
The preparation method of the alcohol disinfectant gel aerosol comprises the following steps: adding carbomer into deionized water, stirring until carbomer completely swells, adding alcohol, humectant, foaming agent and essence, stirring for 15min, adding neutralizer, waiting for 30min to obtain feed liquid, and filling with binary aerosol: filling compressed air into the tank, sealing, filling the feed liquid, and filling low boiling point alkane.
In the alcohol disinfection gel aerosol, ethanol and isopropanol have strong bactericidal effect under reasonable content, and the action mechanism is as follows:
1) The protein denatured ethanol and isopropanol act on bacterial cells to firstly play a role in dehydration, and ethanol and isopropanol molecules enter a peptide chain link of protein molecules to ensure that the protein is subjected to denaturation and precipitation; this effect appears stronger at a content of 70%.
2) Ethanol and isopropanol which damage the bacterial cell wall have strong penetration effect, and 60-85% of ethanol is easy to penetrate into thalli, so that the bacterial cell is damaged and dissolved.
3) The destruction of ethanol and isopropanol in microbial enzyme system can inhibit the normal metabolism and inhibit the growth and reproduction of bacteria by inhibiting the bacterial enzyme system, especially dehydrogenase and oxidase.
The technical effects of the alcohol based antiseptic gel aerosol formulation are further illustrated in the following examples.
Example 1
75% ethanol disinfectant gel aerosol (v/v)
Raw materials: 62kg of 95% edible ethanol, 0.5kg of carbomer U20 (C10-30 alkyl acrylate cross-linked copolymer), pentane: 5kg, triethanolamine 0.5kg, LS-30.5kg, lemon essential oil 0.5kg, glycerol 1kg, and deionized water 31kg.
The preparation method comprises the following steps:
(1) Swelling carbomer: 31kg of deionized water is put into a batching kettle, and then a stirring disperser with the power of 22-35KW and the frequency conversion of 0-3000 r/min is put into the batching kettle, stirring is slowly started, and 0.5kg of carbomer U20 (C10-30 alkyl acrylate crosslinked copolymer) with accurate metering is added while stirring until the carbomer is completely swelled (carbomer is semitransparent).
(2) Preparation of an agent liquid: adding 62kg of 95% ethanol, 1kg of LS-30 glycerol and 0.5kg of lemon essential oil on the basis of the step 1), stirring for 15min, slowly adding triethanolamine, stirring for 30min, inspecting, and sealing and storing the semi-finished product.
(3) And (3) filling a can to obtain a finished product: the binary aerosol filling method comprises (1) filling compressed air into a jar, sealing, filling the above material liquid, and filling low boiling point alkane at a certain proportion. Adding corresponding gel button according to product requirement.
Example 2
70% isopropyl alcohol antiseptic gel aerosol (v/v)
Raw materials: 58kg of isopropyl alcohol, pentane: 6kg, carbomer 980 (C10-30 alkyl acrylate cross-linked copolymer) 0.5kg, APG1080:0.5kg, aminomethyl propanol 0.5kg, lavender essential oil 0.5kg, propylene glycol 1kg, and deionized water 30kg.
The preparation method comprises the following steps:
(1) Swelling carbomer: putting 30kg of deionized water into a blending kettle, putting into a stirring disperser with power of 22-35KW and frequency conversion of 0-3000 r/min, slowly starting stirring, and adding carbomer 980 (0.5 kg) with accurate metering while stirring until carbomer is completely swelled (carbomer is semitransparent).
(2) Preparation of an agent liquid: adding 58kg of isopropanol, APG1080:0.5kg, 1kg of propylene glycol and 0.5kg of lavender essential oil, stirring for 15min, slowly adding aminomethyl propanol, stirring for 30min, inspecting, and sealing and storing the semi-finished product.
(3) And (3) filling a can to obtain a finished product: the binary aerosol filling method comprises 1, filling compressed air into a can, immediately sealing, filling the feed liquid, and filling low boiling point alkane. Adding corresponding gel buttons according to product requirements to obtain the product.
Performance testing
The method for testing the physical, chemical and functional indexes comprises the following steps:
1. appearance of feed liquid: colorless, transparent, viscous liquids were visually examined.
2. Odor: the product is smelled.
3. pH (1%): performed as specified in GB 6920-86.
4. Skin foaming time: 1-2 minutes.
5. Density: performed as specified in GB/T1884.
6. Effective ingredient (v/v)%: is carried out according to the regulations in GB/T2793.
7. The sterilization rate is as follows: the procedure was as described in QB/T2117.
8. Pressure (20 ℃ C.) MPa: performed as specified in GB/T14449.
9. Pressure (50 ℃ C.) MPa: performed as specified in GB/T14449.
10. Heat resistance: the sample is placed in an oven, the temperature is kept at (40 +/-2) DEG C, the sample is taken out after being kept for 24 hours, and the sample is observed after being restored to the room temperature.
11. Cold resistance: and (3) placing the sample in a refrigerator, keeping the temperature at (-5 +/-2) DEG C, taking out the sample after keeping the temperature for 24h, and observing the sample after returning to the room temperature.
The products prepared in examples 1-2 of the present invention were subjected to performance tests, and the obtained quality indexes are shown in table 1 below.
TABLE 1
From the data in table 1, it can be seen that: the invention effectively and rapidly eliminates bacteria and viruses on hands, and the repeated sterilization of hands is an effective way for controlling the spread of epidemic situations. The good sealing performance and the use convenience of the aerosol greatly enhance the effectiveness of the product, and the binary package can effectively keep the use state of the gel.
The technical scope of the present invention is not limited to the above description, and those skilled in the art can make various changes and modifications to the above embodiments without departing from the technical spirit of the present invention, and such changes and modifications should fall within the protective scope of the present invention.
Claims (9)
1. The alcohol disinfection gel aerosol is characterized by comprising disinfection gel and a propellant which are positioned in an aerosol bottle, wherein the disinfection gel comprises, by mass, 58-63 parts of alcohols, 37-42 parts of deionized water, 5-8 parts of low-boiling-point alkane, 0.5-1 part of carbomer, 0.5-1 part of foaming agent, 0.5-1 part of neutralizer, 1-3 parts of humectant and 0.5-1 part of essence.
2. The alcohol disinfecting gel aerosol as claimed in claim 1, wherein the propellant is compressed air, and the compressed air is 0.2 to 0.4 part by mass.
3. The alcohol based disinfecting gel aerosol of claim 1, wherein the alcohol is any one of ethanol and isopropyl alcohol.
4. The alcohol antiseptic gel aerosol of claim 1, wherein the carbomer comprises one or more combinations of carbomer u20, carbomer u22, carbomer 940, and carbomer 980.
5. The aerosol disinfecting gel of claim 1, wherein the foaming agent is one or more of APG1080 or LS-30.
6. The alcohol based antiseptic gel aerosol of claim 1, wherein the neutralizing agent is one or a combination of triethanolamine, sodium hydroxide solution, potassium hydroxide solution, aminomethyl propanol.
7. The alcohol based antiseptic gel aerosol of claim 1, wherein the humectant is one or a combination of two of glycerin and propylene glycol.
8. The alcohol based antiseptic gel aerosol of claim 1, wherein the low boiling alkane is pentane.
9. A method of making an aerosol formulation of an alcohol disinfecting gel according to any one of claims 1 to 8, comprising the steps of:
s1, adding carbomer into deionized water and stirring until the carbomer is completely swelled;
s2, adding alcohol, a humectant, a foaming agent and essence into the mixed solution obtained in the S1, stirring for 15min, and adjusting to be neutral;
and S3, filling the feed liquid obtained in the S2 and the compressed air by a binary aerosol filling method, and then additionally injecting low-boiling-point alkane.
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| CN202210914912.4A CN115212137A (en) | 2022-08-01 | 2022-08-01 | Alcohol disinfection gel aerosol and preparation method thereof |
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| CN202210914912.4A CN115212137A (en) | 2022-08-01 | 2022-08-01 | Alcohol disinfection gel aerosol and preparation method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030661A (en) * | 2015-08-14 | 2015-11-11 | 稳健医疗用品股份有限公司 | Disinfection gel and preparing method of disinfection gel |
| CN106166117A (en) * | 2016-07-06 | 2016-11-30 | 湖北洁之梦生物科技有限公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN106377519A (en) * | 2016-08-31 | 2017-02-08 | 广东同德药业有限公司 | Inflammation preventing, disinfecting, heat rash eliminating and itch relieving aerosol and preparation method thereof |
| CN113967179A (en) * | 2020-07-23 | 2022-01-25 | 山东菏泽三仪生物工程有限公司 | Washing-free hand disinfection gel with skin care effect and preparation method thereof |
| CN114617782A (en) * | 2022-04-26 | 2022-06-14 | 舟山市海大科学技术研究院有限责任公司 | Washing-free disinfection gel and preparation method thereof |
| CN114681338A (en) * | 2020-12-28 | 2022-07-01 | 广东三和化工科技有限公司 | Bathing mousse aerosol and preparation method thereof |
-
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- 2022-08-01 CN CN202210914912.4A patent/CN115212137A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030661A (en) * | 2015-08-14 | 2015-11-11 | 稳健医疗用品股份有限公司 | Disinfection gel and preparing method of disinfection gel |
| CN106166117A (en) * | 2016-07-06 | 2016-11-30 | 湖北洁之梦生物科技有限公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN106377519A (en) * | 2016-08-31 | 2017-02-08 | 广东同德药业有限公司 | Inflammation preventing, disinfecting, heat rash eliminating and itch relieving aerosol and preparation method thereof |
| CN113967179A (en) * | 2020-07-23 | 2022-01-25 | 山东菏泽三仪生物工程有限公司 | Washing-free hand disinfection gel with skin care effect and preparation method thereof |
| CN114681338A (en) * | 2020-12-28 | 2022-07-01 | 广东三和化工科技有限公司 | Bathing mousse aerosol and preparation method thereof |
| CN114617782A (en) * | 2022-04-26 | 2022-06-14 | 舟山市海大科学技术研究院有限责任公司 | Washing-free disinfection gel and preparation method thereof |
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