CN101972451B - Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof - Google Patents
Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof Download PDFInfo
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- CN101972451B CN101972451B CN201010519176XA CN201010519176A CN101972451B CN 101972451 B CN101972451 B CN 101972451B CN 201010519176X A CN201010519176X A CN 201010519176XA CN 201010519176 A CN201010519176 A CN 201010519176A CN 101972451 B CN101972451 B CN 101972451B
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Abstract
The invention discloses a compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and a preparation method thereof, belonging to the veterinary drug technology. The compound infusion preparation of the invention comprises turmeric, Chinese rhubarbs, amur corktree barks, angelica roots, philippine violet herbs, honeysuckle flowers, mongolian dandelion herbs, sargent gloryvine, dahurian patrinia herbs, weeping forsythiae capsule, Gatifloxacin, dexamethasone, Fibriuretinin, dimethyl sulfoxide, glycerol and water for injection, and the total volume is 100ml; and the preparation method comprises the following steps: adding water into the turmeric, the Chinese rhubarbs, the amur corktree barks, the angelica roots, the philippine violet herbs, the honeysuckle flowers, the mongolian dandelion herbs, the sargent gloryvine, the dahurian patrinia herbs and the weeping forsythiae capsule to decoct; concentrating the obtained liquid; adding ethanol into the obtained concentrated solution; standing and filtrating the obtained mixture; then obtaining a Chinese herbal extract after ethanol therein is completely volatilized and has no ethanol flavor exists; blending the dimethyl sulfoxide and the glycerol in the Gatifloxacin, the dexamethasone and the Fibriuretinin; stirring the obtained mixture; then adding the Chinese herbal extract into the obtained mixture; adding the water for injection until the total volume of the obtained product is 100ml; carrying out stirring, dissolving, standing, microfiltration-membrane filtration and sub-packaging on the obtained product; and finally, carrying out moist heat sterilization on the obtained product for 20 minutes at a temperature of 121 DEG C so as to obtain the compound infusion preparation of the invention. The invention has the advantages of wide antimicrobial spectrum, rapid effect taking, and lasting drug effect.
Description
Technical field
The invention belongs to the veterinary drug technology, relate generally to a kind of Chinese medicine and western medicine compound filling agent of treating cattle metritis and preparation method thereof.
Background technology
Metritis is the comparatively common a kind of obstetrics disease of milch cow, the calving interval, prolonged, milk yield reduces, medical expense is big, because of the fertility forfeiture increases mortality, cause very big economic loss.Antibacterial is to cause metritic main pathogen, and encountered pathogenic bacteria is ETEC, staphylococcus aureus, secondly is streptococcus, suppurative actinomycetes, false pseudomonas bacillus, Bacillus proteus, corynebacterium, bacillus cereus and klebsiella.The clinical examination cardinal symptom is the cornua uteri chap, and Uterus wall thickens, and flows out a large amount of dirts or pale brown color mucus purulent secretion from vagina, and a large amount of transudates are accumulated in the severe patient uterus.
At present mainly adopt antibiotic, chemosynthesis antibacterials, treatment by Chinese herbs to metritic treatment, use the antibiotic instant effect but very easily produce Resistant strain to make curative effect descend, especially milk is discarded during the antibiotic therapy can cause treating cost and strengthen; The chemosynthesis antibacterials have powerful killing action to antibacterial, but more single on the function; Chinese medicine is natural drug, have the advantage of no Drug resistance, noresidue, but action effect is slow.Treat the metritic medicine of milch cow in the market, because the unreasonable therapeutic effect of prescription has much room for improvement.
Summary of the invention
The object of the present invention is to provide a kind of metritic Chinese medicine and western medicine compound filling agent of treatment milch cow of new formulation; Combine to process the water solublity filling agent through the Chinese medicine extract of solubilizing agent dimethyl sulfoxide with Chinese medicine and western medicine associating compound preparation, reach the purpose that makes medicine directly treat, play collaborative facilitation uterine lesion with chemical medicine Gatifloxacin, dexamethasone and the promotion detumescence and apocenosis of efficient sterilizing antiinflammatory.
Another object of the present invention provides the method for preparing of said medicine preparation.
Technical scheme of the present invention is:
The metritic Chinese medicine and western medicine compound filling agent of a kind of treatment milch cow is formed by following feedstock production:
Rhizoma Curcumae Longae 5-20g, Radix Et Rhizoma Rhei 5-20g, Cortex Phellodendri 5-20g, Radix Angelicae Dahuricae 5-20g, Herba Violae 5-20g, Flos Lonicerae 5-20g, Herba Taraxaci 5-20g, Caulis Sargentodoxae 5-20g, Herba Patriniae 5-20g, Fructus Forsythiae 5-20g, Gatifloxacin 0.05-1g, dexamethasone 0.01-0.5g, fibrauretin 0.1-0.5g, dimethyl sulfoxide 10-40ml, glycerin 5-20ml, water for injection are to 100ml.
The present invention also provides the method for preparing of the metritic Chinese medicine and western medicine compound filling agent of treatment milch cow, comprises the steps:
1. it is subsequent use to get above-mentioned raw materials; 2. with Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Violae, Flos Lonicerae, Herba Taraxaci, Caulis Sargentodoxae, Herba Patriniae, Fructus Forsythiae decocte with water 2 times, each 2 hours, be concentrated into every milliliter and contain Chinese crude drug 1g; Add 95% ethanol and reach 65%, left standstill 12 hours, filter to containing the alcohol amount; Filtrating adds 95% ethanol to be made and contains the alcohol amount and reach 75%, leaves standstill 12 hours, filters; Filtrating volatilization ethanol is Chinese medicine extraction liquid to there not being the alcohol flavor; 3. dimethyl sulfoxide and glycerin are mixed back adding Gatifloxacin, dexamethasone, fibrauretin, stirring, add Chinese medicine extraction liquid, add the injection water, stir to 100ml; Dissolving, 4 ℃ left standstill 72 hours, 0.45 μ m filtering with microporous membrane; Packing, 121 ℃ of moist heat sterilizations 20 minutes promptly get.
Advantage of the present invention and beneficial effect are: the advantage that Chinese medicine and western medicine combines to have has a broad antifungal spectrum, anti-inflammation detumescence, drug effect continue for a long time and directly act on focus fast; Be easier to absorb treatment; Scientific and reasonable, convenient and swift, the collaborative utilization rate that promotes to have improved medicine of each composition.
The specific embodiment
Describe the present invention below in conjunction with embodiment:
Embodiment 1:
Take by weighing Rhizoma Curcumae Longae 5g, Radix Et Rhizoma Rhei 5g, Cortex Phellodendri 10g, Radix Angelicae Dahuricae 5g, Herba Violae 10g, Flos Lonicerae 10g, Herba Taraxaci 5g, Caulis Sargentodoxae 10g, Herba Patriniae 10g, Fructus Forsythiae 10g, Gatifloxacin 0.2g, dexamethasone 0.05g, fibrauretin 0.5g, measure dimethyl sulfoxide 40ml, glycerin 10ml; With Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Violae, Flos Lonicerae, Herba Taraxaci, Caulis Sargentodoxae, Herba Patriniae, Fructus Forsythiae decocte with water 2 times, each 2 hours, be concentrated into every milliliter and contain Chinese crude drug 1g; Add 95% ethanol and reach 65%, left standstill 12 hours, filter to containing the alcohol amount; Filtrating adds 95% ethanol to be made and contains the alcohol amount and reach 75%, leaves standstill 12 hours, filters; Filtrating volatilization ethanol is Chinese medicine extraction liquid to there not being the alcohol flavor; Dimethyl sulfoxide and glycerin are mixed back adding Gatifloxacin, dexamethasone, fibrauretin, stirring, add Chinese medicine extraction liquid, add the injection water, stir to 100ml; Dissolving, 4 ℃ left standstill 72 hours, 0.45 μ m filtering with microporous membrane; Packing, 121 ℃ of moist heat sterilizations 20 minutes promptly get.
Embodiment 2:
Take by weighing Rhizoma Curcumae Longae 10g, Radix Et Rhizoma Rhei 10g, Cortex Phellodendri 10g, Radix Angelicae Dahuricae 10g, Herba Violae 10g, Flos Lonicerae 5g, Herba Taraxaci 10g, Caulis Sargentodoxae 5g, Herba Patriniae 5g, Fructus Forsythiae 5g, Gatifloxacin 1g, dexamethasone 0.5g, fibrauretin 0.1g, measure dimethyl sulfoxide 40ml, glycerin 5ml; With Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Violae, Flos Lonicerae, Herba Taraxaci, Caulis Sargentodoxae, Herba Patriniae, Fructus Forsythiae decocte with water 2 times, each 2 hours, be concentrated into every milliliter and contain Chinese crude drug 1g; Add 95% ethanol and reach 65%, left standstill 12 hours, filter to containing the alcohol amount; Filtrating adds 95% ethanol to be made and contains the alcohol amount and reach 75%, leaves standstill 12 hours, filters; Filtrating volatilization ethanol is Chinese medicine extraction liquid to there not being the alcohol flavor; Dimethyl sulfoxide and glycerin are mixed back adding Gatifloxacin, dexamethasone, fibrauretin, stirring, add Chinese medicine extraction liquid, add the injection water, stir to 100ml; Dissolving, 4 ℃ left standstill 72 hours, 0.45 μ m filtering with microporous membrane; Packing, 121 ℃ of moist heat sterilizations 20 minutes promptly get.
Embodiment 3:
Take by weighing Rhizoma Curcumae Longae 20g, Radix Et Rhizoma Rhei 20g, Cortex Phellodendri 20g, Radix Angelicae Dahuricae 5g, Herba Violae 5g, Flos Lonicerae 5g, Herba Taraxaci 5, Caulis Sargentodoxae 5g, Herba Patriniae 5g, Fructus Forsythiae 5g, Gatifloxacin 0.1g, dexamethasone 0.01g, fibrauretin 0.1g, measure dimethyl sulfoxide 10ml, glycerin 20ml; With Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Violae, Flos Lonicerae, Herba Taraxaci, Caulis Sargentodoxae, Herba Patriniae, Fructus Forsythiae decocte with water 2 times, each 2 hours, be concentrated into every milliliter and contain Chinese crude drug 1g; Add 95% ethanol and reach 65%, left standstill 12 hours, filter to containing the alcohol amount; Filtrating adds 95% ethanol to be made and contains the alcohol amount and reach 75%, leaves standstill 12 hours, filters; Filtrating volatilization ethanol is Chinese medicine extraction liquid to there not being the alcohol flavor; Dimethyl sulfoxide and glycerin are mixed back adding Gatifloxacin, dexamethasone, fibrauretin, stirring, add Chinese medicine extraction liquid, add the injection water, stir to 100ml; Dissolving, 4 ℃ left standstill 72 hours, 0.45 μ m filtering with microporous membrane; Packing, 121 ℃ of moist heat sterilizations 20 minutes promptly get.
To treat the metritic Chinese medicine and western medicine compound filling agent of milch cow and carry out following test:
1, content of effective determination test:
The quality standard assay item of said preparation be chosen as Gatifloxacin, fibrauretin, dexamethasone, phillyrin.Wherein Gatifloxacin adopts determined by ultraviolet spectrophotometry, and fibrauretin is measured the anhydrous hydrochloric acid palmatine, dexamethasone adopts high-efficient liquid phase technique to measure, and above-mentioned three kinds of content should be the 90.0%-110.0% of labelled amount; These article contain phillyrin must not be less than the 0.015g/ bottle.
Above-mentioned three batches of preparations are same preparation technology embodiment product, and the production inventory is 105% of a recipe quantity.But, character reasonable by above-mentioned data product technology stablized, and can produce in batches.
2, stability test: the condition held 12 months that three batches of products is packaged in 25 ℃ ± 2 ℃ of temperature, relative humidity 60% ± 10% by finished product; Sampling in per 3 months once detected by stable high spot reviews project respectively at 0 month, 3 months, 6 months, 9 months, 12 months.After 12 months, carry out outward appearance, content, sterility test respectively at sampling in 18 months, 24 months.
Conclusion: character of the present invention, content detection, sterility test are all qualified, meet " People's Republic of China's veterinary drug allusion quotation 2005 editions " related request.
3, safety testing
Give the rat oral gavage administration every day with these article senior amount group 20ml/kgBW and low dose group 2ml/kgBW, in continuous 10 weeks, observe the reaction of rat physiological status.Activities in rats is normal as a result, and body weight, internal organs, blood preparation are compared no significant difference with matched group, and blood parameters does not have significant change, and the rat heart, liver, kidney, stomach are all normal through histological examination.
4, effect test
The inventor has carried out application test with the metritic Chinese medicine and western medicine compound filling agent of homemade treatment milch cow in Fructus Pruni forestry and animal husbandry cattle farm in Harbin.
(1) materials and methods
Trial target: the metritic Chinese medicine and western medicine compound filling agent of homemade treatment milch cow
(2) metritis diagnostic criteria
Slightly: the examination per rectum Uterus wall has slightly and thickens, and a little less than the slightly weak or contractile response of one or both sides cornua uteri contractile response, from vagina, flows out white fritter shape secretions or mucus, floccule.
Moderate: the examination per rectum Uterus wall has obviously and thickens, and the abundant swelling in palace and form irregular protuberantia can be felt in the palpation uterus, accumulates liquid in the cavity of uterus, from vagina, flow out white secretions or mucus be white in color, cotton-shaped.
Severe: the examination per rectum Uterus wall has obviously and thickens, and uterine volume increases also has tangible longitudinal furrow and protuberantia, accumulates liquid in the cavity of uterus, from vagina, flows out white, pussy discharge.
(3) experimental animal and grouping
Choose 75 the first-borns time 1～3 parity, the age milch cow in puerperal at 3～5 years old, observation is diagnosed as metritis with the uterus exudate in the per rectum inspection.The test of cure group is divided into 3 groups by the state of an illness: slight (41), moderate (20) and severe (14).
(4) test method
Adopt the dabbling method dispensing in uterus, 1 50ml of every interval dispensing in 3 days, logotype 3 times.Carried out the uterus examination per rectum on the 10th day after the medication, the cattle of recovery from illness stops treatment, the Niu Jixu treatment of not curing.
(5) healing is judged: adopt the observation judgement of examination per rectum and vaginal secretions for the judgement of therapeutic effect: the contractile response of uterus and cornua uteri is good, and the uterus quality is soft, elasticity is good, and vaginal secretions is limpid, nothing is muddy for fully recovering
(6) result
| The treatment group | A test number | Cure number | Do not cure number | Cure rate |
| Slight group | 41 | 37 | 4 | 90.2％ |
| The moderate group | 20 | 16 | 4 | 80％ |
| The severe group | 14 | 10 | 4 | 71.4％ |
| Amount to | 75 | 63 | 12 | 84％ |
(7) conclusion
The present invention is used for treatment milk cattle metritis has tangible curative effect, and total cure rate reaches 84%, and various degree metritiss are all produced effect, and can promote evacuation of pus, detumescence, antibacterial, antiinflammatory, and acute, chronic, pyometritis are had curative effect.
Claims (2)
1. treat the metritic Chinese medicine and western medicine compound filling agent of milch cow for one kind, it is characterized in that: this agent is formed by following feedstock production: Rhizoma Curcumae Longae 5-20g, Radix Et Rhizoma Rhei 5-20g, Cortex Phellodendri 5-20g, Radix Angelicae Dahuricae 5-20g, Herba Violae 5-20g, Flos Lonicerae 5-20g, Herba Taraxaci 5-20g, Caulis Sargentodoxae 5-20g, Herba Patriniae 5-20g, Fructus Forsythiae 5-20g, Gatifloxacin 0.05-1g, dexamethasone 0.01-0.5g, fibrauretin 0.1-0.5g, dimethyl sulfoxide 10-40ml, glycerin 5-20ml, water for injection are to 100ml.
2. the metritic Chinese medicine and western medicine compound filling agent of an a kind of treatment milch cow as claimed in claim 1 method for preparing is characterized in that this method comprises the steps: 1. to get raw material for standby; 2. with Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Cortex Phellodendri, the Radix Angelicae Dahuricae, Herba Violae, Flos Lonicerae, Herba Taraxaci, Caulis Sargentodoxae, Herba Patriniae, Fructus Forsythiae decocte with water 2 times, each 2 hours, be concentrated into every milliliter and contain Chinese crude drug 1g; Add 95% ethanol and reach 65%, left standstill 12 hours, filter to containing the alcohol amount; Filtrating adds 95% ethanol to be made and contains the alcohol amount and reach 75%, leaves standstill 12 hours, filters; Filtrating volatilization ethanol is Chinese medicine extraction liquid to there not being the alcohol flavor; 3. dimethyl sulfoxide and glycerin are mixed back adding Gatifloxacin, dexamethasone, fibrauretin stirring, add Chinese medicine extraction liquid, add the injection water, stir to 100ml; Dissolving, 4 ℃ left standstill 72 hours, 0.45 μ m filtering with microporous membrane; Packing, 121 ℃ of moist heat sterilizations 20 minutes promptly get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201010519176XA CN101972451B (en) | 2010-10-26 | 2010-10-26 | Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof |
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| CN201010519176XA CN101972451B (en) | 2010-10-26 | 2010-10-26 | Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof |
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| CN101972451A CN101972451A (en) | 2011-02-16 |
| CN101972451B true CN101972451B (en) | 2012-05-02 |
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| CN102772699B (en) * | 2012-08-03 | 2013-08-21 | 陈红梅 | Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease |
| CN111494509A (en) * | 2020-04-17 | 2020-08-07 | 洛阳朗威动物药业有限公司 | A Chinese medicinal injection for treating mastitis of milk cow, and its preparation method |
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| CN1186086C (en) * | 2003-06-11 | 2005-01-26 | 山东农业大学 | Composition for preventing and treating milk cow from bateria disease |
| CN100486575C (en) * | 2006-11-29 | 2009-05-13 | 北京大北农动物保健科技有限责任公司 | Pharmaceutical composition for treating bacterial infection of milched cow, preparation process and use thereof |
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Granted publication date: 20120502 Termination date: 20191026 |