CN102824440A - Traditional Chinese medicine composition for treating dairy cow mastitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating dairy cow mastitis and preparation method thereof Download PDFInfo
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- CN102824440A CN102824440A CN201210288502XA CN201210288502A CN102824440A CN 102824440 A CN102824440 A CN 102824440A CN 201210288502X A CN201210288502X A CN 201210288502XA CN 201210288502 A CN201210288502 A CN 201210288502A CN 102824440 A CN102824440 A CN 102824440A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating dairy cow mastitis. The traditional Chinese medicine composition is a medicament prepared from the following raw materials expressed in weight parts: 5 to 8 parts of green tangerine peel, 5 to 8 parts of liquorice root and 8 to 15 parts of dandelion. The traditional Chinese medicine composition provided by the invention has the effects of clearing heat, removing toxins, activating blood circulation to expel blood stasis and resolve static blood, removing edema and promoting lactation and can overcome defects like milk pollution and poor quality of dairy products caused by antibiotic treatment. According to results of clinical diagnosis and treatment, the traditional Chinese medicine composition has a remarkable treatment effect, and milk yield of a dairy cow quickly returns to normal after the dairy cow is healed.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of treating bovine mastitis and preparation method thereof.
Background technology
A kind of cow mammary gland inflammation that bovine mastitis (bovine mastitis) is meant infected by microbes or causes because of physicochemical irritation can be caused by multiple pathogenic bacteria jointly or separately, is to cause one of the most serious disease of dairy loss.According to the bibliographical information whole world 2,2 hundred million cow heads are arranged approximately, wherein have 1/3 milch cow to suffer from various types of mastitis approximately.Bovine mastitis causes enormous economic loss every year as regular incidence, frequently-occurring disease in the milk cattle cultivating industry.The generation of bovine mastitis also produces very big influence to the quality of milk, and cause of disease milk comes into the market and causes public health event easily.So the scientific prevention and cure to bovine mastitis is the work that pay much attention to the cattle farm always.
The treatment bovine mastitis still mainly adopts antibiotic at present; But people have recognized that this can not fundamentally solve the problem of bovine mastitis, because be that whole body or breast innerlich anwenden are difficult to all make that antibiotic reaches valid density in the milk, particularly microorganism such as staphylococcus aureus can colonize in the cell; Or behind antibiotic therapy, form L-type bacterium; Continue the chronic infection breast, therefore long-term a large amount of generations of using antibiotic not only to cause Resistant strain reduce therapeutic effect; Antibiotic also makes the milch cow immunologic function be suppressed simultaneously; Cause easily again and infect, the more important thing is that drug tolerant bacteria also can make human body after this milk of long-term drink, produce certain Drug resistance through milk-born infection to the people.
The Chinese medicine of existing treatment bovine mastitis is mostly processed by the raw material more than four kinds, though have certain therapeutic effect, because raw material is many, so impurity is also many, might exist certain impurity to be difficult to remove.How raw material also makes final dosage big in addition, and dosage greatly not only makes the administration difficulty, also is prone to cause milch cow untoward reaction after administration, to occur.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of treating bovine mastitis, said composition not only therapeutic effect is good, and administration is easy, can not cause milch cow untoward reaction after administration, to occur.
Another object of the present invention is to provide the method for preparing of above-mentioned bovine mastitis therapeutic agent.
Chinese medicine composition of the present invention is processed by following materials of weight proportions: Pericarpium Citri Reticulatae Viride 5-8 part, Radix Glycyrrhizae 5-part, Herba Taraxaci 8-15 part.
The optimum weight proportioning of Chinese medicine composition of the present invention is: 5 parts on Pericarpium Citri Reticulatae Viride, 5 parts in Radix Glycyrrhizae, 10 parts of Herba Taraxacis.
Chinese medicine composition of the present invention can be made into injection or granule.
The method for preparing of Chinese medicine composition of the present invention is: by weight getting Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae and Herba Taraxaci, add Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae and Herba Taraxaci gross weight 5-25 water boiling and extraction doubly 1-3 time, each 0.5-2 hour; Merge extractive liquid,, it is 1.05-1.25 that extracting solution is concentrated into relative proportion, adds ethanol then and makes the alcohol amount of containing be 50-90%; Leave standstill more than 12 hours, filter, get filtrating; It is concentrated, drying promptly makes intermediate, gets intermediate, and it is prepared into injection or granule.
Chinese medicine composition of the present invention has effects such as heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, eliminating stagnation, detumescence stimulating milk secretion, can overcome defectives such as milk pollution that antibiotic therapy causes, quality of dairy products difference.Prove that through clinic diagnosis its therapeutic effect is obvious, milch cow is cured the back milk yield and recovers normal very soon.In addition, Chinese medicine composition of the present invention is owing to only processed by three kinds of raw materials, and therefore not only Impurity removal is easy, and convenient drug administration, can not cause milch cow untoward reaction after administration, to occur.
Further specify effect of the present invention through clinical experiment below.
1. experimental animal
The clinical trial case is cultured the sub-district from certain.Have typical clinical type mastitis symptom through clinical diagnosis, breast has symptoms such as red, swollen, hot, pain in various degree, and the milk character is unusual, is pale yellow or light red, and milk is thin or sticky, does not have the other diseases that occurs together.
2. test drug and diagnostic reagent
Injection of the present invention (lot number 120101) (adopting the prescription of embodiment 1);
Penicillin sodium (800,000 IU, lot number: A120104003);
Streptomycin (1,000,000 μ g, lot number: 120106);
Diagnostic reagent liquid (LMT, specification 500 mL/ bottles, lot number: 20120111).
3. clinical mastitis diagnosis and efficacy determination method
Symptom such as that the clinical examination breast has is red, swollen, hot, pain and milk matter have become sour, whether indexs such as water sample, the blood streak, deposition, pus, abnormal flavour judge ill; Length according to disease time is divided into acute, subacute and chronic mastitis, sends out and recurrence at the beginning of dividing according to the morbidity number of times.Efficacy determination: recovery from illness, clinical symptom disappearance, it is normal that milk recovers, and somatic number (SCC) is less than 500,000/mL in the LMT detection milk.Effectively, clinical symptom disappearance, it is normal that milk recovers, and LMT detects SCC between 500,000～1,000,000/mL.Invalid, clinical symptoms does not disappear even increases the weight of, and milk still has ANOMALOUS VARIATIONS, and LMT detects SCC greater than 1,000,000/mL.
Calculate effective percentage with formula, the result adopts the reference differential technique to carry out statistical analysis:
Effective percentage (%)=(recovery from illness case load+effective case load)/total case load * 100
Cure rate (%)=recovery from illness case load/total case load * 100
4. the grouping and the administering mode of clinical type mastitis case
32 sick cattle that suffer from mastitis that will have typical clinical symptom are divided into two groups at random; The 1st group is treatment group of the present invention (20): the length according to disease time is divided into acute group (7), subacute group (7) and chronic mastitis group (6); Squeeze clean milk back with 75% cotton ball soaked in alcohol sterilization nipple rear udder attachment perfusion infusion liquid of the present invention; Every day twice, each 30ml, logotype 4d; The 2nd group is blue or green, streptomycin treatment group: the length according to disease time is divided into acute group (4), subacute group (4) and chronic mastitis group (4); Each each breast district penicillin sodium 800,000 IU; Streptomycin 1,000,000 μ g dissolve with normal saline 40mL; Squeeze to the greatest extent the milk back with 75% cotton ball soaked in alcohol sterilization nipple after the newborn chamber of injection, every day 2 times, logotype 4d.Massage about breast 3～5min with hands after having annotated medicinal liquid, make medicine evenly diffusion in breast as far as possible, promote to absorb.
5. result of the test
Result of the test shows: it is 86.2% that the present invention treats clinical type mastitis total effective rate, and average cure rate is that 83.5% green grass or young crops, streptomycin treatment group total effective rate are 83.4%, and average cure rate 76.3% explains that test group has better therapeutic effect.
The specific embodiment
Embodiment 1 (injection)
Prescription: Pericarpium Citri Reticulatae Viride 250g Radix Glycyrrhizae 250g Herba Taraxaci 500g
Method for preparing:
(1) gets Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae and Herba Taraxaci by above-mentioned weight ratio, add the water extraction 3 times of 15 times of its gross weights, each 1 hour; Merge extractive liquid,, it is 1.20 that extracting solution is concentrated into relative proportion, adds ethanol then and makes that to contain alcohol amount be 80%; Left standstill 24 hours, and filtered, get filtrating; It is evaporated to relative proportion is 1.25, and drying promptly makes intermediate;
(2) get water for injection 1000ml, be heated to boiling, add above-mentioned intermediate then, and stir; Transferring its pH value is 6-8, and the post-heating that stirs is to seething with excitement about 15 minutes, places 0-4 ℃ of cold preservation 24 hours again after being cooled to room temperature then; Filter, get filtrating and be heated to boiling, add the active carbon of filtrating weight 0.5% then; Stirred 3 minutes, and filtered, filtrating is cooled to room temperature after; Supply water for injection to 1000ml, with 0.22,0.45 micron microporous filter membrane filtration, embedding (20ml/ props up), sterilization promptly make respectively.
Usage and dosage: be poured in the cow breast every day 1-2 time, each 10-50ml, logotype 4-7 days.
Embodiment 2 (granule)
Prescription: Pericarpium Citri Reticulatae Viride 200g Radix Glycyrrhizae 300g Herba Taraxaci 600g
Method for preparing:
(1) get Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae and Herba Taraxaci by above-mentioned weight ratio, add the water extraction 2 times of 8 times of its gross weights, each 1 hour, merge extractive liquid; It is 1.10 that extracting solution is concentrated into relative proportion, adds ethanol then and makes that to contain alcohol amount be 65%, leaves standstill 24 hours; Filter, get filtrating, it is evaporated to relative proportion is 1.25; Drying promptly makes intermediate, gets intermediate and adds an amount of dextrin, behind granulation, drying, granulate, promptly makes granule of the present invention.
Usage and dosage: admix in the feedstuff and use, every day 3 times, each 10-50g.
Embodiment 3 (injection)
Prescription: Pericarpium Citri Reticulatae Viride 350g Radix Glycyrrhizae 250g Herba Taraxaci 400g
Method for preparing:
(1) gets Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae and Herba Taraxaci by above-mentioned weight ratio, add the water extraction 3 times of 20 times of its gross weights, each 1.5 hours; Merge extractive liquid,, it is 1.20 that extracting solution is concentrated into relative proportion, adds ethanol then and makes that to contain alcohol amount be 85%; Left standstill 24 hours, and filtered, get filtrating; It is 1.25 that its concentrating under reduced pressure is done extremely relative proportion, and drying promptly makes intermediate;
(2) get water for injection 1000ml, be heated to boiling, add above-mentioned intermediate then, and stir; Transferring its pH value is 6-8, and the post-heating that stirs is to seething with excitement about 15 minutes, places 0-4 ℃ of cold preservation 24 hours again after being cooled to room temperature then; Filter, get filtrating and be heated to boiling, add the active carbon of filtrating weight 0.5% then; Stirred 3 minutes, and filtered, filtrating is cooled to room temperature after; Supply water for injection to 1000ml, with 0.22,0.45 micron microporous filter membrane filtration, embedding (20ml/ props up), sterilization promptly make respectively.
Usage and dosage: be poured in the cow breast every day 1-2 time, each 10-50ml, logotype 4-7 days.
Claims (4)
1. a Chinese medicine composition of treating bovine mastitis is characterized in that said composition is the medicament of being processed by the following weight proportion raw material: Pericarpium Citri Reticulatae Viride 5-8 part, Radix Glycyrrhizae 5-8 part, Herba Taraxaci 8-15 part.
2. the Chinese medicine composition of treatment bovine mastitis according to claim 1 is characterized in that the weight proportion of each raw material is: 5 parts on Pericarpium Citri Reticulatae Viride, 5 parts in Radix Glycyrrhizae, 10 parts of Herba Taraxacis.
3. the Chinese medicine composition of treatment bovine mastitis according to claim 1 and 2 is characterized in that said medicament is injection or granule.
4. the method for preparing of the Chinese medicine composition of the said treatment bovine mastitis of claim 1 is characterized in that: by weight getting Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae and Herba Taraxaci, add its gross weight 5-25 water boiling and extraction doubly 1-3 time; Each 0.5-2 hour, merge extractive liquid,, it is 1.05-1.25 that extracting solution is concentrated into relative proportion; Add ethanol then and make the alcohol amount of containing be 50-90%, leave standstill more than 12 hours, filter; Get filtrating; It is concentrated, drying promptly makes intermediate, gets intermediate, and it is prepared into injection or granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758432A (en) * | 2014-12-10 | 2015-07-08 | 北京康华远景科技股份有限公司 | Botanical drug preparation for treating mastitis of dairy cow and preparation method thereof |
| CN105560374A (en) * | 2016-01-26 | 2016-05-11 | 中国农业科学院兰州畜牧与兽药研究所 | Compound preparation for treating dairy cow mammitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548723A (en) * | 2009-01-10 | 2009-10-07 | 内蒙古通辽岳泰股份有限公司 | Concentrate supplement biological additive for lactating dairy cows |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548723A (en) * | 2009-01-10 | 2009-10-07 | 内蒙古通辽岳泰股份有限公司 | Concentrate supplement biological additive for lactating dairy cows |
Non-Patent Citations (1)
| Title |
|---|
| 阎丽萍: "银花汤对奶牛急性乳腺炎的治疗", 《中兽医学杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758432A (en) * | 2014-12-10 | 2015-07-08 | 北京康华远景科技股份有限公司 | Botanical drug preparation for treating mastitis of dairy cow and preparation method thereof |
| CN104758432B (en) * | 2014-12-10 | 2018-06-19 | 北京康华远景科技股份有限公司 | A kind of autonomic drug preparation for treating mastitis for milk cows and preparation method thereof |
| CN105560374A (en) * | 2016-01-26 | 2016-05-11 | 中国农业科学院兰州畜牧与兽药研究所 | Compound preparation for treating dairy cow mammitis and preparation method thereof |
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