CN1330349C - Chinese medicine composition for treating urethra infection and preparing method - Google Patents
Chinese medicine composition for treating urethra infection and preparing method Download PDFInfo
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- CN1330349C CN1330349C CNB2005101280602A CN200510128060A CN1330349C CN 1330349 C CN1330349 C CN 1330349C CN B2005101280602 A CNB2005101280602 A CN B2005101280602A CN 200510128060 A CN200510128060 A CN 200510128060A CN 1330349 C CN1330349 C CN 1330349C
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Landscapes
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Abstract
The present invention discloses a novel medicine for curing urethral infection and a preparing method thereof. The medicine for curing urethral infection is a clinical acceptable preparation prepared from astragali, pink herb, indian buead, Common Yan Rhizome, radix aconiti lateralis preparata, glabrous greenbrier rhizome, etc. as raw materials processed by different physical or chemical methods according to different physical or chemical properties of each traditional Chinese medicine. The present invention has peculiar formula and has remarkable curative effect when used for curing urethral infection in clinical practice.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of new treatment urinary tract infection, is the Chinese patent medicine that feedstock production forms with the Chinese herbal medicine specifically, relates to the preparation method of this medicine simultaneously.
Background technology
Urinary tract infection is a kind of commonly encountered diseases of China, frequently-occurring disease.According to domestic statistics, the sickness rate male of China's urine sense is 0.23%, and the women is 2.37%.Men and women, old and young all can fall ill, especially with reproduction age the married woman be common, sickness rate improves clinic case every year with 5.4% speed increase, the situation and the age of onset that have occurred making people worried are tending towards becoming younger, patient less than 30 years old accounts for 72.1%, and its rejuvenation trend is obvious.Plyability infects ratio and increases, and single pathogenic infection person accounts for 66.9%, and two or more pathogenic infection persons account for 33.1%, and the person detects 5 kinds of pathogen at most.Urine sense sickness rate accounts for 0.91% of total population, is the 2nd cause of disease that causes chronic renal failure; Clinical serves as main performance with frequent micturition, urgent micturition, dysurea, pus, urine and bacteriuria.
At present domestic many by pathogen, diseased region and different in kind, and adopt different therapeutic schemes:
1, due to the specificity UTI overwhelming majority is infected by gram negative bacilli, so should select for use to the antibacterials of this bacterioid sensitivity medicine commonly used such as bactrim, quinolones, nitrofurantoin, amoxicillin, piperacillin, cefradine, cefuroxime, cephalo plug oxime, rocephin, micronomicin and netilmicin etc.
2, the treatment of fungus UTI is many treats with amphotericin B, and amphotericin B is the broad-spectrum antifungal medicine, and the whole body administration only is used for serious case.
3, the treatment of spreading through sex intercourse property urinary tract infection (1) gonococcal urethritis quinolones is for first-selected, as norfloxacin, ofloxacin or ciprofloxacin etc.; (2) nongonococcal urethritis generally uses treatments such as doxycycline, oxytetracycline, tetracycline.
But the coincidence rate of general external drug sensitive test result of medicine and clinical effectiveness only is 70%-80%.Simultaneously medication effect can be subjected to strain and have or not factor affecting such as urinary tract obstruction.Sense of complexity urine or the infection that obtains in hospital, Resistant strain is more, and Bacillus proteus, bacillus pyocyaneus etc. easily produce drug resistance and are difficult to reach good therapeutic effect multiple antibiotic; The most administration time of urinary tract infection is long simultaneously, and medical expense is big, uses antibiotics easily to produce untoward reaction such as anaphylaxis, hepatic and renal function damage.
Chinese medicine preparation should play an important role in the treatment urinary tract infection, and the wide world is arranged.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of urinary tract infection, another object of the present invention provides the preparation method of this medicine.
Medicine of the present invention is according to theory of Chinese medical science, develops at the pathomechanism of urinary tract infection.Urinary tract infection is the gonorrhea categories that belong in the traditional Chinese medical science more, the cause of disease belongs to damp and hot more, and the traditional Chinese medical science is thought the urinary tract infection symptom, for damp-heat accumulation in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, damp-heat in the urinary bladder superinverse and kidney then cause lumbago and suffer from a deficiency of the kidney; With the passing of time gonorrhea undermines the spleen kidney, and then the spleen deficiency of the kidney is decreased, deficiency of vital energy deficiency, and sick clearing away heat-damp and promoting diuresis just, stranguria treating and diuresis inducing is its basic rule of treatment.It is generally acknowledged: gonorrhea must very be given birth to wet by heat, humidogene and turbid liquid excreted from the body condenses and be pouring.Zhang Jingyue is also thought: stranguria is relevant with long-pending intrinsic heat poison, and hot person is suitable clear, and wet person is suitable sharp.We are exactly that theory of Chinese medical science adopts clearing away heat-damp and promoting diuresis, and stranguria treating and diuresis inducing is the rule of treatment attached product with invigorate vital energy and yang simultaneously.
Chinese medicine of the present invention is by organic compatibility of multiple medicine, and treating both the principal and secondary aspects of a disease both can at the misery of the rapid reduction of patient of symptom, have more superiority than simple chemical compound and biological preparation again at etiological treatment.And Chinese medicine is natural product, and toxic and side effects is little, and medication is safer.
Chinese medicine composition of the present invention is made by following raw materials according:
Radix Astragali 4-60 weight portion Herba Dianthi 4-30 weight portion Poria 4-30 weight portion
Rhizoma Dioscoreae 7-60 weight portion Radix Aconiti Lateralis Preparata 1-30 weight portion Rhizoma Smilacis Glabrae 7-120 weight portion.
The formula optimization weight proportion scope of preparation Chinese medicine composition of the present invention is:
Radix Astragali 4-60 weight portion Herba Dianthi 4-30 weight portion Poria 4-30 weight portion
Rhizoma Dioscoreae 7-60 weight portion Radix Aconiti Lateralis Preparata 1-30 weight portion Rhizoma Smilacis Glabrae 7-120 weight portion
Herba Violae 7-60 weight portion Herba Taraxaci 4-30 weight portion Spica Prunellae 4-30 weight portion
Rhizoma Imperatae 4-30 weight portion Bulbus Lilii 3-25 weight portion.
The formula optimization weight proportion scope of preparation Chinese medicine composition of the present invention is:
Radix Astragali 9-30 weight portion Herba Dianthi 9-15 weight portion Poria 9-15 weight portion
Rhizoma Dioscoreae 15-30 weight portion Radix Aconiti Lateralis Preparata 3-15 weight portion Rhizoma Smilacis Glabrae 15-60 weight portion
Herba Violae 15-30 weight portion Herba Taraxaci 9-15 weight portion Spica Prunellae 9-15 weight portion
Rhizoma Imperatae 9-15 weight portion Bulbus Lilii 6-12 weight portion.
The optimum weight proportioning of preparation Chinese medicine composition of the present invention is:
The Radix Astragali 15 weight portion Herba Dianthis 10 weight portion Poria 10 weight portions
Rhizoma Dioscoreae 20 weight portion Radix Aconiti Lateralis Preparata 8 weight portion Rhizoma Smilacis Glabraes 25 weight portions
Herba Violae 20 weight portion Herba Taraxacis 10 weight portion Spica Prunellaes 10 weight portions
Rhizoma Imperatae 10 weight portion Bulbus Liliies 10 weight portions.
The preparation method that above-mentioned each component is made Chinese medicine composition of the present invention is:
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt the 40%-80% ethanol extraction method, add alcohol reflux 1-3 time, and each 1-3 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 1-3 time, add 5-10 times of water at every turn, decocted 1-3 hour, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1-3: 1, and transfer alcohol to 40%-85%, Cryoprecipitation 12-48 hour, filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge or is dry, adds appropriate amount of auxiliary materials and makes clinical receptible various dosage forms with the conventional formulation method, promptly.
Traditional Chinese medicine composition for treating urinary tract infection of the present invention has better curative effect.For showing the therapeutical effect of Chinese medicine composition of the present invention to urinary tract infection, we have done a large amount of experimentatioies, below experimental example be used to further specify the present invention.
The Pharmacodynamic test of active extract data of preparation of the present invention
(1) antibacterial action
[test objective] observes the interior and vitro antibacterial activity of body of preparation of the present invention.
[being subjected to the reagent thing]
1, medicine name: preparation of the present invention.
2, the unit of providing: Lunan Pharmacy Co. Ltd.
3, contrast medicine: SANJIN PIAN, Sanjin Pharmaceutical Group Co, Guilin.
[animal]
1, source, kind, strain, the quality certification: Anhui Prov. Medical Science Inst.'s Experimental Animal Center provides, Kunming mouse, outbreeding sealing system, moving accurate No. 01 of Anhui doctor.
2, body weight: 18-22g
3, sex: ♂ ♀ half and half.
4, number of animals: 120,20 every group.
5, experimental situation: laboratory temperature is 18～28 ℃, and relative humidity is 50～70%.
6, pellet: Ying Quan health and happiness laboratory animal feed corporation,Ltd provides by Fuyang.
[reagent and instrument]
Strain and the preparation of bacterium liquid: all strains all derive from Anhui Chinese Medicine College microbiology teaching and research room.Staphylococcus aureus is type strain ATCC25923; Escherichia coli are reference culture ATCC25922, buy from Nat'l Pharmaceutical ﹠ Biological Products Control Institute strain preservation center; Golden yellow Fructus Vitis viniferae ball pathogenic bacterium obtain for gathering on one's body from the patient to separate, and through identifying conclusive evidence.Other strains also obtain for gathering on one's body from the patient to separate, and through identifying conclusive evidence.Staphylococcus aureus, Staphylococcus albus, escherichia coli are adopted broth medium.Increase the toxic agent high activity dried yeast: Hubei Angel Yeast Co.,Ltd produces, lot number: 20030807.Nutrient agar: Beijing three medicine scientific and technological development companies produce, lot number: 010220; Peptone: Shanghai Da Chang meat packing plant, code name: Q/YRAA80; Beef extract: Chinese Medicine Shanghai chemical reagents corporation, lot number: F20030621.Sodium chloride: Shishewei Chemical Co., Ltd., Shanghai, lot number: 011006.
The double single face clean work station of instrument: SW-CJ-2FD Purifying Equipment Co., Ltd., Suzhou makes; SKP-01 electro-heating standing-temperature cultivator Huangshi city medical apparatus and instruments factory; 78-1 Constant Temp. Oven Huangshi medical apparatus and instruments factory; The portable High pressure steam sterilizer of YXQSG41280 electric heating Shanghai Medical Nuclear Instrument Factory.
[test method]
1, solid medium bacteriostatic test: adopt cup-plate method, the solid medium different according to different strain preparation is poured into culture medium in the culture dish, and cooling makes solidifies.To be tried strain in 37 ℃ of cultivations, and make concentration reach about 300,000,000/ml.Bacterium liquid is coated the solid culture primary surface, put standard Oxford cup (purchasing) in Nat'l Pharmaceutical ﹠ Biological Products Control Institute.Medicine is prepared with sterile distilled water with, positive control drug SANJIN PIAN, with aseptic dropper medicine is joined in the cup of Oxford, and till filling it up with the Oxford cup, negative control adds physiological saline solution.Antibacterial is cultivated 24h for 37 ℃, observes antibacterial circle diameter (mm), the results are shown in Table 1.
Table 1 preparation of the present invention is to the measurement result (mm) of various antibacterial bacteriostatic levels
| Antibacterial | Preparation of the present invention | Positive control drug | Normal saline |
| Staphylococcus aureus | 13.6±1.1 | 12.7±1.1 | 0 |
| Staphylococcus albus | 12.8±0.7 | 13.5±1.0 | 0 |
| First is paid Bacillus typhi | 13.0±1.1 | 11.9±1.1 | 0 |
| Second is paid Bacillus typhi | 14.6±1.6 | 12.5±1.3 | 0 |
| Pay cold bar bar | 13.3±0.8 | 12.7±1.0 | 0 |
| Escherichia coli | 14.0±1.1 | 14.1±1.4 | 0 |
By table 1 result as seen, preparation of the present invention all has certain antibacterial action to 6 kinds of common bacterium such as intestinals, and the diameter of its inhibition zone is between 10～17mm.
2, the mensuration of minimum inhibitory concentration (MIC)
According to conventional literature method, get 132 of sterile test tube, divide equally 2 groups, establish row's (11) test tube by each strain.Preparation of the present invention and SANJIN PIAN are mixed with solution respectively as original content.Diluted by reagent thing original content with fluid medium by coubling dilution, in the medicinal liquid of every pipe 2ml, culture fluid mixed liquor, add bacterium liquid 0.1ml (through 37 ℃ of diluents of 1: 100 cultivating the bacterium liquid of 6h), last pipe gives over to the meat soup contrast, and jolting evenly back is cultivated 24h in 37 ℃.Observe the turbidity of test tube, clear and bright with test tube as antibacterial positive pipe.The results are shown in Table 2, table 3.
The MIC pH-value determination pH of table 2 preparation of the present invention
| Strain | Drug dilution concentration (the g crude drug/ml) | MIC (the g crude drug/ml) | ||||||||||
| 1∶1 | 1∶2 | 1∶4 | 1∶8 | 1∶16 | 1∶32 | 1∶64 | 1∶128 | 1∶256 | 1∶512 | NS | ||
| Gold Portugal bacterium | - | - | + | + | + | + | + | + | + | + | + | 0.7013 |
| White Portugal bacterium | - | - | + | + | + | + | + | + | + | + | + | 0.7013 |
| First is paid Bacillus typhi | - | - | + | + | + | + | + | + | + | + | + | 0.7013 |
| Second is paid Bacillus typhi | - | - | - | + | + | + | + | + | + | + | + | 0.3506 |
| Bacillus typhi | - | - | - | - | + | + | + | + | + | + | + | 0.1753 |
| Escherichia coli | - | - | + | + | + | + | + | + | + | + | + | 0.7013 |
The MIC pH-value determination pH of table 3 positive control drug
| Strain | Drug dilution concentration (g/m) | MIC (the g content/ml) | ||||||||||
| 1∶1 | 1∶2 | 1∶4 | 1∶8 | 1∶16 | 1∶32 | 1∶64 | 1∶128 | 1∶256 | 1∶512 | NS | ||
| Gold Portugal bacterium | - | - | + | + | + | + | + | + | + | + | + | 0.0625 |
| White Portugal bacterium | - | - | - | + | + | + | + | + | + | + | + | 0.0313 |
| First is paid Bacillus typhi | - | - | - | + | + | + | + | + | + | + | + | 0.0313 |
| Second is paid Bacillus typhi | - | - | + | + | + | + | + | + | + | + | + | 0.0625 |
| Bacillus typhi | - | - | + | + | + | + | + | + | + | + | + | 0.0625 |
| Escherichia coli | - | - | + | + | + | + | + | + | + | + | + | 0.0625 |
From above result as seen, the present invention all has bacteriostasis to 6 kinds of antibacterials being tested, and the MIC value is from 0.1753～0.7013g crude drug/ml.
3, the mouse peritoneal that causes of staphylococcus aureus infects the influence of dead model
Get 120 of mices, body weight 18～22g, male and female half and half are divided into 6 groups at random.Be respectively the blank group of 5% dry yeast, the normal saline model group, the SANJIN PIAN group, preparation of the present invention is little, in, heavy dose of group (be equivalent to respectively clinical consumption 5,10,20 times), each group is irritated stomach respectively and is given 0.2ml/10g corresponding test liquid, once a day, for three days on end, every Mus lumbar injection is through the staphylococcus aureus bacterium liquid 0.5ml (containing bacterium about 1.5 hundred million) after the prerun after the last administration, administration same dosage repeat administration on same day secondary, continue administration 7 days, observe mortality of mice in the week, the results are shown in Table 4.
The mouse peritoneal that table 4 pair staphylococcus aureus causes infects the influence of dead model
| Medicine | Number of animals (only) | Death toll (only) | Mortality rate (%) | |||
| 24h | 48h | 72h | 7 days dead altogether | 5.0 | ||
| Blank group | 20 | 1 | 1 | |||
| Normal saline | 20 | 15 | 2 | 17 | 85.0 | |
| Blood stasis of prostatic gland dredging | 20 | 3 | 4 | 2 | 10 | 50.0 * |
| Small dose group | 20 | 8 | 3 | 2 | 13 | 65.0 |
| Middle dosage group | 20 | 3 | 3 | 2 | 9 | 45.0 * |
| Heavy dose of group | 20 | 3 | 4 | 1 | 8 | 40.0 ** |
Use NDST software, adopt the direct probability method statistics of Fisher,
*P＜0.05,
*P＜0.05, the vs normal saline
By table 4 result as seen, the dead mouse that under the big or middle dosage of preparation of the present invention staphylococcus aureus is caused has the certain protection effect.
(2), the clinical observation of preparation of the present invention
1, diagnostic criteria
(1) tcm diagnosis standard damp invasion of lower energizer disease: heating, fear of cold, waist are ached, frequent micturition, urgent micturition, urethra are stung puckery pain, yellowish or reddish urine, yellowish fur, wiry and frequent pulse or sliding number.
(2) Western medicine diagnose standard
1. regular CCMS (require urine rest in the bladder more than 4～6 hours) bacteria quantified is cultivated clump count 〉=10
5/ mL.
2. clean centrifugal midstream urine sediment leukocyte count＞10/HP, the urinary tract infection symptom is arranged.
On possessing 1., 2. two can make a definite diagnosis.As not having 2., then should remake the check of urine bacterium counting, as still 〉=10
5/ mL, and the identical person of twice antibacterial.
2, experiment case standard
(1) includes standard in
Meet above-mentioned Western medicine diagnose and Chinese medical discrimination person.
(2) exclusion standard
1. acute prostatitis;
2. acute urinary tract infection;
3. hepatic and kidney function obstacle, disease of hematopoietic system, mentally disordered person;
4. allergic constitution person.
3, group technology: by the table of random number method, randomized, double-blind is divided into treatment group (preparation of the present invention) 100 examples with study subject, and matched group 100 examples were carried out controlled trial by 1: 1, and each checking unit treatment group, matched group are no less than 20 examples.
4, administrated method:
1. treatment group: preparation of the present invention.
2. matched group: SANJIN PIAN
3. course of treatment: 3 days was 1 course of treatment.
4. administrated method: in observational technique, adopt randomized, double-blind two simulate carry out controlled trial, select A group medicine or B group medicine more at random for use according to the random table method, end to be treated is taken off blind by manufacturer.
5, curative effect is judged
1. clinical cure: symptom and sign disappears, and it is normal that routine urianlysis recovers for 2 times, urine bacterium feminine gender.
2. produce effects: symptom and sign obviously improves, and routine urianlysis is normal or near normal, urine bacterium feminine gender.
3. effective: symptom and sign obviously improves, and routine urianlysis improves, the urine bacterium positive.
4. invalid: symptom and sign does not have improvement or worsens, and routine urianlysis improves not obvious, the urine bacterium positive.
6, observation and record
1. according to the experimental program requirement, examine patient, conscientiously fill in the observation table, must not arbitrarily alter.
2. note observing the untoward reaction of not expecting and taking place, as the reaction that notes abnormalities, should conscientiously differentiate, confirm as untoward reaction, itemized record, and take its corresponding measures, severe patient should be in time to the experiment unit of taking the lead and administrative department of public health's report.
3. after experiment finished, each experimental unit should conscientiously array data, and checks data, carried out necessary statistical procedures.And transfer to the unit of taking the lead and gather.
7, reject the case standard
1. do not meet the standard of including in
2. do not drop by the wayside the person
3. not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.
8, therapeutic outcome
100 examples are organized in treatment, clinical cure 51 examples (51%), produce effects 36 examples (36%), effective example 8 (8%), invalid 5 examples (5%), matched group 100 examples, clinical cure 48 examples (48%), produce effects 27 examples (27%), effective example 16 (16%), invalid 9 examples (9%).
The result: preparation curative effect of the present invention is better than matched group.
Following embodiment is further openly the present invention, need to prove that these embodiment only for optimal way of the present invention, do not limit the scope of protection of present invention.
Embodiment 1
Radix Astragali 4g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 40% ethanol extraction method, add alcohol reflux 1 time, and each 1 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 1 time, add 10 times of water at every turn, decoct 1 hour, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfer alcohol to 40%, Cryoprecipitation 48 hours filters, concentrating under reduced pressure becomes extractum, add dextrin, Icing Sugar system granule, drying, system granule, packing promptly gets granule.
Embodiment 2
Radix Astragali 60g Herba Dianthi 4g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 80% ethanol extraction method, add alcohol reflux 3 times, and each 3 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 3 times, add 5 times of water at every turn, decoct 3 hours; merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1; transfer alcohol to 85%, Cryoprecipitation 12 hours filters; concentrating under reduced pressure becomes extract dry; add an amount of dextrin, Icing Sugar system soft material, granulator is granulated, drying; packing promptly gets granule.
Embodiment 3
Radix Astragali 60g Herba Dianthi 30g Poria 4g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 50% ethanol extraction method, add alcohol reflux 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 2 times, add 8 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 2, transfer alcohol to 50%, Cryoprecipitation 24 hours filters, and concentrating under reduced pressure becomes extractum, dry, add starch system granule, the fill capsule promptly gets capsule.
Embodiment 4
Radix Astragali 60g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 7g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 60% ethanol extraction method, add alcohol reflux 3 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 2 times, add 10 times of water at every turn, decoct 1.5 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, transfer alcohol to 55%, Cryoprecipitation 48 hours filters, and concentrating under reduced pressure becomes extractum, dry, adding Icing Sugar, starch are made granule in right amount, and tabletting promptly gets tablet.
Embodiment 5
Radix Astragali 60g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 1g Rhizoma Smilacis Glabrae 120g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 70% ethanol extraction method, add alcohol reflux 2 times, and each 2.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 2 times, add 10 times of water at every turn, decoct 2.5 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, transfer alcohol to 60%, Cryoprecipitation 24 hours filters, and concentrating under reduced pressure becomes extractum, dry, add appropriate amount of starch, the general ball of making promptly gets pill.
Embodiment 6
Radix Astragali 60g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 7g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 75% ethanol extraction method, add alcohol reflux 3 times, and each 2.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 2 times, add 10 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 65%, and Cryoprecipitation 12-48 hour, filter, concentrating under reduced pressure becomes extractum, drying, mixing sieves, and promptly gets powder.
Embodiment 7
Radix Astragali 15g Herba Dianthi 10g Poria 10g
Rhizoma Dioscoreae 20g Radix Aconiti Lateralis Preparata 8g Rhizoma Smilacis Glabrae 25g
Herba Violae 20g Herba Taraxaci 10g Spica Prunellae 10g
Rhizoma Imperatae 10g Bulbus Lilii 10g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 65% ethanol extraction method, add alcohol reflux 3 times, and each 3 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 3 times, add 10 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfer alcohol to 80%, Cryoprecipitation 48 hours filters, concentrating under reduced pressure becomes extractum, adds 10 times of water, stirs, Cryoprecipitation 48 hours filters, and filtrate concentrates, to regulating PH to 4, add 0.1% active carbon, heated and boiled 30 minutes is filtered, add to the full amount of water for injection, filter, fine straining, lyophilization is aseptic subpackaged, check promptly gets the powder pin.
Embodiment 8
Radix Astragali 30g Herba Dianthi 9g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
With above medicine crushing screening, it is an amount of to add binding agent Mel, and pill promptly gets pill.
Embodiment 9
Radix Astragali 9g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 80% ethanol extraction method, add alcohol reflux 2 times, and each 1 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 2 times, add 10 times of water at every turn, decoct 3 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, transfer alcohol to 85%, Cryoprecipitation 48 hours filters, concentrating under reduced pressure becomes extractum, add 8 times of water, Cryoprecipitation 48 hours filters, filtrate concentrates, to regulating PH to 7, add 0.1% active carbon, heated and boiled 30 minutes, filter, add to the full amount of water for injection, filter fine straining, the embedding sterilizing test promptly gets and infuses.
Embodiment 10
Radix Astragali 30g Herba Dianthi 15g Poria 9g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 65% ethanol extraction method, add alcohol reflux 3 times, and each 1 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 3 times, add 8 times of water at every turn, decoct 1.5 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfer alcohol to 85%, Cryoprecipitation 24 hours filters, concentrating under reduced pressure becomes extractum, adds 10 times of water, stirs, Cryoprecipitation 48 hours filters, and filtrate concentrates, to regulating PH to 4, add 0.1% active carbon, heated and boiled 30 minutes is filtered, add to the full amount of water for injection, filter, fine straining, lyophilization is aseptic subpackaged, check promptly gets the powder pin.
Embodiment 11
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 15g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 45% ethanol extraction method, add alcohol reflux 3 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 2 times, add 10 times of water at every turn, decoct 3 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 55%, Cryoprecipitation 24 hours, filter, concentrating under reduced pressure becomes extractum to go into the ethanol of normal concentration, stirs, filter, promptly get tincture.
Embodiment 12
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 3g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 50% ethanol extraction method, add alcohol reflux 2 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 2 times, add 10 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfer alcohol to 75%, Cryoprecipitation 12 hours filters, concentrating under reduced pressure becomes extractum, and is dry with the substrate heating and melting, adds dry medicated powder, mixing, impouring scribble in the bolt mould of releasing agent, cooling, take out, promptly get suppository.
Embodiment 13
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 15g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 55% ethanol extraction method, add alcohol reflux 1 time, and each 3 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 3 times, add 8 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfer alcohol to 45%, Cryoprecipitation 12 hours filters, and concentrating under reduced pressure becomes extractum, it is an amount of to add water, filter, other gets sucrose and adds an amount of heated and boiled of water, dissolving, filter, concentrate and make syrup,, boil with above-mentioned concentrated solution mixing, put cold, add antiseptic and essence, thin up promptly gets syrup.
Embodiment 14
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 15g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 60% ethanol extraction method, add alcohol reflux 2 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 2 times, add 6 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfer alcohol to 50%, Cryoprecipitation 48 hours filters, concentrating under reduced pressure becomes extractum, and it is an amount of to add water, filters, add water to full dose, filter fill, sterilization promptly gets mixture.
Embodiment 15
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 9g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 65% ethanol extraction method, add alcohol reflux 3 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 3 times, add 10 times of water at every turn, decoct 3 hours; merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1; transfer alcohol to 40%; Cryoprecipitation 12 hours filters, and concentrating under reduced pressure becomes extractum; drying and crushing; add an amount of dextrin, magnesium stearate, stevioside, mixing, with dry granulation mechanism grain, promptly.
Embodiment 16
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 9g
Rhizoma Imperatae 15g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 70% ethanol extraction method, add alcohol reflux 3 times, and each 3 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 3 times, add 10 times of water at every turn, decoct 3 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfer alcohol to 55%, Cryoprecipitation 12 hours filters, and concentrating under reduced pressure becomes extractum, it is an amount of to add water, filter, other gets sucrose and adds an amount of heated and boiled of water, dissolving, filter, concentrate and make syrup,, boil with above-mentioned concentrated solution mixing, put cold, add antiseptic and essence, thin up promptly gets syrup.
Embodiment 17
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 9g Bulbus Lilii 12g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 75% ethanol extraction method, add alcohol reflux 3 times, and each 1 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 3 times, add 5 times of water at every turn, decoct 1 hour, merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, transfer alcohol to 40%, Cryoprecipitation 12 hours filters, concentrating under reduced pressure becomes extractum, and drying is with Icing Sugar, the system granule, drying, packing promptly gets granule.
Embodiment 18
Radix Astragali 30g Herba Dianthi 15g Poria 15g
Rhizoma Dioscoreae 30g Radix Aconiti Lateralis Preparata 15g Rhizoma Smilacis Glabrae 60g
Herba Violae 30g Herba Taraxaci 15g Spica Prunellae 15g
Rhizoma Imperatae 15g Bulbus Lilii 6g.
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 70% ethanol extraction method, add alcohol reflux 1 time, and each 3 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 1 time, add 10 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfer alcohol to 50%, Cryoprecipitation 36 hours filters, concentrating under reduced pressure becomes extractum, drying adds lactose, the sweet mixing of A Siba, dry granulation, packing promptly gets granule.
Embodiment 19
Radix Astragali 4g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 80% ethanol extraction method, add alcohol reflux 2 times, and each 1 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 2 times, add 10 times of water at every turn, decoct 3 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1, transfers alcohol to 85%, Cryoprecipitation 48 hours, filter, concentrating under reduced pressure becomes extractum, adds 8 times of water, Cryoprecipitation 48 hours, filter, filtrate concentrates, and to regulating PH to 7, adds 0.1% active carbon, heated and boiled 30 minutes is filtered, and adds to the full amount of water for injection, and filters, fine straining, the embedding sterilizing test promptly gets and infuses.
Embodiment 20
Radix Astragali 60g Herba Dianthi 4g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 65% ethanol extraction method, add alcohol reflux 3 times, and each 1 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 3 times, add 8 times of water at every turn, decoct 1.5 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 3: 1, transfers alcohol to 85%, and Cryoprecipitation 24 hours filters, concentrating under reduced pressure becomes extractum, adds 10 times of water, stirs Cryoprecipitation 48 hours, filter, filtrate concentrates, and to regulating PH to 4, adds 0.1% active carbon, heated and boiled 30 minutes is filtered, and adds to the full amount of water for injection, and filters, fine straining, lyophilization is aseptic subpackaged, and check promptly gets the powder pin.
Embodiment 21
Radix Astragali 60g Herba Dianthi 30g Poria 4g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 45% ethanol extraction method, add alcohol reflux 3 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 2 times, add 10 times of water at every turn, decoct 3 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 55%, Cryoprecipitation 24 hours, filter, concentrating under reduced pressure becomes extractum to go into the ethanol of normal concentration, stirs, filter, promptly get tincture.
Embodiment 22
Radix Astragali 6g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 7g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 120g
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 55% ethanol extraction method, add alcohol reflux 3 times, and each 2 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 2 times, add 10 times of water at every turn, decoct 3 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 55%, Cryoprecipitation 24 hours, filter, concentrating under reduced pressure becomes extractum to go into the ethanol of normal concentration, stirs, filter, promptly get tincture.
Embodiment 23
Radix Astragali 60g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 1g Rhizoma Smilacis Glabrae 120g
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 55% ethanol extraction method, add alcohol reflux 1 time, and each 3 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 3 times, add 8 times of water at every turn, decoct 2 hours, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1, transfers alcohol to 45%, Cryoprecipitation 12 hours, filter, concentrating under reduced pressure becomes extractum, and it is an amount of to add water, filters, other gets sucrose and adds an amount of heated and boiled of water, and dissolving is filtered, and concentrates to make syrup, with above-mentioned concentrated solution mixing, boil, put cold, add antiseptic and essence, thin up promptly gets syrup.
Embodiment 24
Radix Astragali 60g Herba Dianthi 30g Poria 30g
Rhizoma Dioscoreae 60g Radix Aconiti Lateralis Preparata 30g Rhizoma Smilacis Glabrae 7g
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt 65% ethanol extraction method, add alcohol reflux 3 times, and each 1.5 hours, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae decoct with water 3 times, add 10 times of water at every turn, decoct 3 hours; merge decoction liquor, filter, be evaporated to medical material: water is about 2: 1; transfer alcohol to 40%; Cryoprecipitation 12 hours filters, and concentrating under reduced pressure becomes extractum; drying and crushing; add an amount of dextrin, magnesium stearate, stevioside, mixing, with dry granulation mechanism grain, promptly.
Claims (7)
1, a kind of Chinese medicine composition for the treatment of urinary tract infection is characterized in that preparing its consisting of of primary raw material:
Radix Astragali 4-60 weight portion Herba Dianthi 4-30 weight portion Poria 4-30 weight portion
Rhizoma Dioscoreae 7-60 weight portion Radix Aconiti Lateralis Preparata 1-30 weight portion Rhizoma Smilacis Glabrae 7-120 weight portion.
2,, it is characterized in that the active component for preparing it consists predominantly of according to the described Chinese medicine composition of claim 1:
Radix Astragali 4-60 weight portion Herba Dianthi 4-30 weight portion Poria 4-30 weight portion
Rhizoma Dioscoreae 7-60 weight portion Radix Aconiti Lateralis Preparata 1-30 weight portion Rhizoma Smilacis Glabrae 7-120 weight portion
Herba Violae 7-60 weight portion Herba Taraxaci 4-30 weight portion Spica Prunellae 4-30 weight portion
Rhizoma Imperatae 4-30 weight portion Bulbus Lilii 3-25 weight portion.
3,, it is characterized in that the active component for preparing it consists predominantly of according to the described Chinese medicine composition of claim 2:
Radix Astragali 9-30 weight portion Herba Dianthi 9-15 weight portion Poria 9-15 weight portion
Rhizoma Dioscoreae 15-30 weight portion Radix Aconiti Lateralis Preparata 3-15 weight portion Rhizoma Smilacis Glabrae 15-60 weight portion
Herba Violae 15-30 weight portion Herba Taraxaci 9-15 weight portion Spica Prunellae 9-15 weight portion
Rhizoma Imperatae 9-15 weight portion Bulbus Lilii 6-12 weight portion.
4, the described Chinese medicine composition of claim 3 is characterized in that the active component weight proportion for preparing it is:
The Radix Astragali 15 weight portion Herba Dianthis 10 weight portion Poria 10 weight portions
Rhizoma Dioscoreae 20 weight portion Radix Aconiti Lateralis Preparata 8 weight portion Rhizoma Smilacis Glabraes 25 weight portions
Herba Violae 20 weight portion Herba Taraxacis 10 weight portion Spica Prunellaes 10 weight portions
Rhizoma Imperatae 10 weight portion Bulbus Liliies 10 weight portions.
5,, be characterised in that the dosage form of this medicine is: granule, capsule, tablet, injection, tincture, suppository, pill, syrup, mixture, powder, lotion, membrane, drop pill according to claim 1,2,3 or 4 described Chinese medicine compositions.
6,, it is characterized in that the said dosage form of this medicine is a granule according to claim 1,2,3 or 4 described Chinese medicine compositions.
7,, it is characterized in that the preparation method of this medicine is according to claim 1,2,3 or 4 described Chinese medicine compositions:
The Radix Astragali, Radix Aconiti Lateralis Preparata adopt the 40%-80% ethanol extraction method, add alcohol reflux 1-3 time, and each 1-3 hour, medicinal liquid filtered, reclaims ethanol, concentrates; Herba Dianthi, Poria, Rhizoma Dioscoreae, Rhizoma Smilacis Glabrae, Herba Violae, Herba Taraxaci, Spica Prunellae, Bulbus Lilii, Rhizoma Imperatae decoct with water 1-3 time, add 5-10 times of water at every turn, decocted 1-3 hour, merge decoction liquor, filter, be evaporated to medical material: water is about 1: 1-3: 1, and transfer alcohol to 40%-85%, Cryoprecipitation 12-48 hour, filter, concentrating under reduced pressure becomes extractum and alcohol reflux extractum to merge or is dry, adds appropriate amount of auxiliary materials and makes clinical receptible various dosage forms with the conventional formulation method, promptly.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101280602A CN1330349C (en) | 2005-11-25 | 2005-11-25 | Chinese medicine composition for treating urethra infection and preparing method |
| HK06113691A HK1092725A1 (en) | 2005-11-25 | 2006-12-13 | Chinese medicine composition for treating urinary tract infection and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2005101280602A CN1330349C (en) | 2005-11-25 | 2005-11-25 | Chinese medicine composition for treating urethra infection and preparing method |
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| CN1814221A CN1814221A (en) | 2006-08-09 |
| CN1330349C true CN1330349C (en) | 2007-08-08 |
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| CNB2005101280602A Active CN1330349C (en) | 2005-11-25 | 2005-11-25 | Chinese medicine composition for treating urethra infection and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104208356A (en) * | 2014-09-26 | 2014-12-17 | 禤燕华 | Chinese medicinal composition for treating urethral diseases |
| CN104324201A (en) * | 2014-11-18 | 2015-02-04 | 郝建友 | Traditional Chinese medicine preparation for treating urinary system infection and production method |
| CN104474390B (en) * | 2014-11-19 | 2018-09-11 | 王小龙 | A kind of Chinese medicine for treating overactive bladder and palindromic urinary tract infection |
| CN105596462A (en) * | 2016-01-22 | 2016-05-25 | 章雪妮 | Traditional Chinese medicine preparation for treating urinary system infection and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174075A (en) * | 1997-07-12 | 1998-02-25 | 迟经惠 | Medicine for arteriosclerosis |
| CN1284349A (en) * | 2000-03-20 | 2001-02-21 | 范永昌 | Medicine pill for preventing and treating pathological seaility |
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2005
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174075A (en) * | 1997-07-12 | 1998-02-25 | 迟经惠 | Medicine for arteriosclerosis |
| CN1284349A (en) * | 2000-03-20 | 2001-02-21 | 范永昌 | Medicine pill for preventing and treating pathological seaility |
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| CN1814221A (en) | 2006-08-09 |
| HK1092725A1 (en) | 2007-02-16 |
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Denomination of invention: The invention relates to a traditional Chinese medicine composition for treating urinary tract infection and a preparation method thereof Effective date of registration: 20211228 Granted publication date: 20070808 Pledgee: China Construction Bank Corporation Linyi Shizhong sub branch Pledgor: LUNAN HOPE PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016801 |
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