CN101461850A - Application of Chinese medicinal composition in preparing medicament for treating acne - Google Patents
Application of Chinese medicinal composition in preparing medicament for treating acne Download PDFInfo
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- 206010000496 acne Diseases 0.000 title claims abstract description 42
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 18
- SHGAZHPCJJPHSC-UHFFFAOYSA-N Panrexin Chemical compound OC(=O)C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-UHFFFAOYSA-N 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 19
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- 238000002360 preparation method Methods 0.000 claims description 17
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to application of a known traditional Chinese medicine composition in preparing medicines for treating other diseases, in particular to application of a traditional Chinese medicine composition for treating symptoms such as throat abscess, oral erosion and gingival pain in preparing medicines for treating acne. The traditional Chinese medicine comprises the following compositions by weight percentage: 10 to 50 percent of borneol, 10 to 50 percent of liquorice, 8 to 38 percent of root of subprostrate sophora roots, 2 to 25 percent of calcite, 1 to 15 percent of Coptis chinensis, 0.5 to 5 percent of indigo, 0.5 to 5 percent of Renzhongbai, 1 to 3 percent of pearls and 1 to 3 percent of calculus bovis factitious. The medicine has good inhibition function on propionibacterium acnes and good treatment function on acnes.
Description
Technical field
The present invention relates to the application of a kind of known Chinese medicine composition in the medicine of preparation treatment other diseases, the particularly a kind of application of Chinese medicine composition in the preparation Retinoids, Retin-A, Renova, Accutane for the treatment of diseases such as laryngopharynx swelling and pain, oral erosion, gingiva pain.
Background technology
Acne is good sending out in pilosebaceous chronic inflammation disease, and the title of acne, rosacea caused by lung-wind is arranged.Just on the books in Golden Mirror of Medicine: " this card is formed by the lung meridian heat in blood, and every is played broken pimple in the face nose, and shape such as broomcorn millet are considered to be worth doing, and red complexion swells and ache, and breaks out white lead juice." at present the modern study achievement about the acne mechanism of causing a disease mainly concentrate on the following aspects: 1. androgen and sebaceous gland hyperfunctioning.There are some researches show that the generation and the sex hormone receptor of acne are closely related, under androgenic effect, sebaceous gland activity strengthens, and causes lipid to be secreted in a large number, and this also is considered to the precondition that acne takes place.2. the influence of microorganism.Showed increased such as propionibacterium acnes, staphylococcus epidermidis in the pilosebaceous unit can think that bacterial infection is an one of the main reasons in the patients with acne paathogenic factor, and propionibacterium acnes were main pathogenic bacterium when acne took place according to research reports.3. the pilosebaceous duct hyperkeratosis also is the pathogenetic important step of acne.In addition, Nervous and Mental Factors, The food stimulation, medicine androgen etc. all can become the reason that increases the weight of or inspire acne.The traditional Chinese medical science is heat clearing away, invigorates blood circulation the remedy of acne principle, reuses heat clearing Chinese medicine.Because acne mainly betides facial area, diminish appearance, so along with the raising of people's living standard, the control of acne comes into one's own day by day.
The exterior-applied prescription of treatment acne is a lot of at present, for example Chinese patent application 98114618.x number " Chinese medicine liquid for eliminating acne and skin care ", number 93115910.5 " acne Herba Senecionis Dianthui prescription and compound method ", number 94106098.5 " preparation method of Chinese medicine face mask for treating acne and purposes ", number 97108499.8 " Chinese medicine buauty liquid capable of eliminating acne and whitening skin ", number 98111997.2 " skin nursing cream for curing comedo ", 200410046999.X the manufacture method of " a kind of medicine for external use for the treatment of acne " and 200510016875.1 " compound ointment for treating acne " discloses the external used medicine of some treatment acnes respectively, but its curative effect is had no way of as can be known, therefore seeks safer, more effective medicine is the target that researcheres are pursued always.
This patent that the applicant applied for belongs to a kind of new medicinal usage.To be called " a kind of pharmaceutical composition ", the day for announcing be that 2005.10.26, publication number are CN1686271 for publication CN200510034073.3, name.This disclosure of the Invention a kind of Chinese medicine composition and preparation method, this Chinese medicine composition is formed by following proportioning raw materials: Borneolum Syntheticum 10-50%, Radix Glycyrrhizae 10-50%, Radix Sophorae Tonkinensis 8-38%, Mirabilitum crystallina 2-25%, Rhizoma Coptidis 1-15%, Indigo Naturalis 0.5-5%, calamitas urinae hominis 0.5-5%, Margarita 1-3%, artificial Calculus Bovis people 1-3%.Its preparation method is as follows: (1) extracting liquorice, Radix Sophorae Tonkinensis, Mirabilitum crystallina, Rhizoma Coptidis, Indigo Naturalis, calamitas urinae hominis, artificial Calculus Bovis, Margarita pulverize separately become fine powder; (2) with above fine powder mixing, to pulverize through jet mill, fineness is to become micropowder about 5 μ m; (3) with micropowder and an amount of lactose, mannitol, maltodextrin and correctives mixing, granulation, 55 ℃ of dryings; (4) Borneolum Syntheticum is dissolved in the ethanol in proportion, sprays into above granule, airtight, add behind the lubricant tabletting tablet.Or the adding adjuvant, make powder or capsule.This invention is primarily aimed at laryngopharynx swelling and pain, oral erosion, gingiva pains and other diseases, and its prescription has the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, blood stasis-eliminating and stagnation-dissipating pain relieving, removing toxic substances and promoting granulation.
Through experimental study in recent years, the applicant finds that this Chinese medicine composition treats the effect of acne in addition, and up to the present, the report of finding above-mentioned composition treatment acne is not arranged also.
Summary of the invention
Purpose of the present invention just provides the application of Chinese medicine composition in the preparation Retinoids, Retin-A, Renova, Accutane of diseases such as the disclosed treatment laryngopharynx swelling and pain of CN1686271, oral erosion, gingiva pain.
The application of a kind of Chinese medicine composition in the preparation Retinoids, Retin-A, Renova, Accutane, the proportioning of each constituent of described Chinese medicine composition is as follows:
Borneolum Syntheticum 10-50%, Radix Glycyrrhizae 10-50%, Radix Sophorae Tonkinensis 8-38%, Mirabilitum crystallina 2-25%, Rhizoma Coptidis 1-15%, Indigo Naturalis 0.5-5%, calamitas urinae hominis 0.5-5%, Margarita 1-3%, artificial Calculus Bovis 1-3%.
Be preferably: Borneolum Syntheticum 27.12%, Radix Glycyrrhizae 27.12%, Radix Sophorae Tonkinensis 18%, Mirabilitum crystallina 12.4%, Rhizoma Coptidis 9.04%, Indigo Naturalis 2.256%, calamitas urinae hominis 2.256%, Margarita 0.904%, artificial Calculus Bovis 0.904%.
The medicine of described treatment acne is said any exterior-applied formulation on the pharmaceutics; Comprise ointment, cream, gel, liniment.
The preparation method of above-mentioned Retinoids, Retin-A, Renova, Accutane is: (1) extracting liquorice, Radix Sophorae Tonkinensis, Mirabilitum crystallina, Rhizoma Coptidis, Indigo Naturalis, calamitas urinae hominis, artificial Calculus Bovis, Margarita pulverize separately become fine powder or with above fine powder mixing, pulverize through jet mill, fineness is to become micropowder about 1--10 μ m; (2) with above fine powder or micropowder and a certain amount of Borneolum Syntheticum and an amount of external-use substrate mixing, make said any exterior-applied formulation on the clinical acceptable pharmaceutics.
Following the applicant will illustrate that this medicine has the purposes for the treatment of acne and describes by concrete pharmacodynamics test.
Pharmacodynamics test
Extracorporeal bacteria inhibitor test
Press liquid tube method, this law can be quantitatively and sensitivity higher.
Above-mentioned each Chinese medicine is named the SL powder by the preferred proportion mixing, is mixed with every ml and contains crude drug 2.5mg, 1.25mg, 0.63mg, 0.32mg, 0.16mg, 0.08mg and 0.04 totally seven drug level, every pipe total amount 1ml, steam sterilization.
The blank pipe: the strain contrast, for not containing the culture medium of medicine.The medicine contrast is not for containing the medicinal liquid of test organisms.
From refrigerator, take out acne Acne (P.ac/be) strain (leaving in the kitchen meat culture fluid paraffin sealing in), draw the 1ml strain with aseptic straw and put into sterilized 1% THIOGLYCOLLIC ACID salt culture fluid test tube, place 37 ℃ of cultivation 48h in the anaerobic jar.Take out staphylococcus aureus simultaneously, staphylococcus epidermidis (depositing and the brucella broth culture fluid) is inoculated in slant culture liquid, cultivates 24h for 37 ℃.Acne Acne, staphylococcus aureus, the staphylococcus epidermidis that will be in exponential phase are diluted to 0.5 Maxwell reduced turbidity with 0.9% physiology, are inoculated in and are equipped with in the sterilized culture fluid test tube, and adjusting bacterium liquid final concentration is 10
-3～10
-4CFU/ml draws a certain amount of medicinal liquid and is added to respectively in the culture fluid test tube that has contained bacterium liquid, three parallel pipes of every kind of medicine.
With the turbidity is index, and each pipe of perusal has asepsis growth, judges minimal inhibitory concentration (MIC).MIC: be meant the minimum drug level that complete inhibition test bacteria growing is contained.The results are shown in following table:
The minimal inhibitory concentration MIC of medicine administered to bring out the cold thing (mg/ml)
Annotate: the test organisms of each blank pipe is obviously growth all.
The SL powder all has antibacterial action in various degree to examination strain acne Acne, staphylococcus aureus, staphylococcus epidermidis, and is between 0.08--1.52mg/ml, wherein stronger to the effect of acne Acne to the MIC of each bacterium.
SL gel clinical observation on the therapeutic effect
Subjects: university student volunteer's 60 examples, wherein male 26 examples, 20.3 years old mean age, women 34 examples, 23.2 years old mean age.Suffer from pimple, fester, types such as blackhead are acne.With the order of severity of face simplex number diagnosis acne, 20 above persons are severe, and several 10～20 persons of herpes are moderate, and several 10 the following persons of herpes are slight.In 60 examples, severe person's 25 examples, moderate person's 25 examples, slight person's 10 examples.
Using method: after washing one's face, entire face is evenly smeared the SL gel, each 1 time sooner or later.Used for 4 weeks as 1 course of treatment continuously.Inactive other treatment acne oral medicine of duration of test and medicine for external use.
Efficacy evaluation: cure and be that the herpes 95% above person of disappearing, produce effects are the herpes 60% above person of disappearing, effectively disappear more than 30% or the obvious alleviator of inflammation, invalidly be the herpes 30% following person of disappearing for herpes, or with treatment before compare and do not have obviously progress person.Use this product to evaluate effect after 1 course of treatment continuously.
The result: cure 20 examples (34%), produce effects 29 examples (49%), effective 10 examples (17%), invalid 1 example (2%), total effective rate is 99%.Average responding time is about 2～3 weeks, and the slight fast person of patients with acne just took effect in 3～5 days.More after, the calm speckle of several non-pigments of damaging part, the cicatrix number obviously alleviates, and the skin commentaries on classics is delicate, smooth, fair and clear, does not find that at duration of test side reactions such as skin irritation, allergy occur.
Prescription analysis
Not only heat-clearing and toxic substances removing, erosion prevention and muscle growing promote the effect of Transdermal absorption to Borneolum Syntheticum in addition in this prescription; Radix Glycyrrhizae heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, antiallergic, antipruritic, pigment desalination; Radix Sophorae Tonkinensis, Rhizoma Coptidis heat-clearing and toxic substances removing and propionibacterium acnes had stronger inhibitory action; Mirabilitum crystallina, Margarita be heat-clearing and toxic substances removing but also be rich in healing, the desalination color element that various trace elements promotes the skin ulcer face through modern study not only; Skin ulcer, blood cooling and ecchymoses removing are held back in the Indigo Naturalis detoxifcation; Calamitas urinae hominis, artificial Calculus Bovis's heat-clearing and toxic substances removing have the effect of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, removing toxic substances and promoting granulation, reparation skin ulcer face with this this prescription.
The specific embodiment
Further specify the present invention below in conjunction with embodiment, but this can not think limitation of the present invention.
Embodiment one:
Borneolum Syntheticum 27.12%, Radix Glycyrrhizae 27.12%, Radix Sophorae Tonkinensis 18%, Mirabilitum crystallina 12.4%, Rhizoma Coptidis 9.04%, Indigo Naturalis 2.256%, calamitas urinae hominis 2.256%, Margarita 0.904%, artificial Calculus Bovis 0.904%.
Preparation method is that (1) extracting liquorice, Radix Sophorae Tonkinensis, Mirabilitum crystallina, Rhizoma Coptidis, Indigo Naturalis, calamitas urinae hominis, artificial Calculus Bovis, Margarita pulverize separately become fine powder; (2) in above ratio with above fine powder mixing, pulverize through jet mill, fineness is to become micropowder about 5 μ m; (3) with above micropowder and Borneolum Syntheticum and hexadecanol 100g, paraffin 100g, white vaseline 150g, polyoxyethylene alkyl ether 0.25g, ethyl hydroxybenzoate 1g, glycerol 50g, distilled water adds to 1000g, and ointment is made in mixing, sterilization.
Embodiment two
Borneolum Syntheticum 30%, Radix Glycyrrhizae 30%, Radix Sophorae Tonkinensis 25%, Mirabilitum crystallina 5%, Rhizoma Coptidis 5%, Indigo Naturalis 0.8%, calamitas urinae hominis 0.5%, Margarita 2.5%, artificial Calculus Bovis 1.2%.
Preparation method is that (1) extracting liquorice, Radix Sophorae Tonkinensis, Mirabilitum crystallina, Rhizoma Coptidis, Indigo Naturalis, calamitas urinae hominis, artificial Calculus Bovis, Margarita pulverize separately become fine powder; (2) in above ratio with above fine powder mixing, pulverize through jet mill, fineness is to become micropowder about 5 μ m; (3) get above micropowder and Borneolum Syntheticum add up to 3% with hexadecanol 16%, white vaseline 40%, soil temperature 48%, distilled water adds to 100%, mixing, sterilization cream.
Embodiment three
Borneolum Syntheticum 15.75%, Radix Glycyrrhizae 40%, Radix Sophorae Tonkinensis 28%, Mirabilitum crystallina 5%, Rhizoma Coptidis 5%, Indigo Naturalis 0.5%, calamitas urinae hominis 1.25%, Margarita 3%, artificial Calculus Bovis 1.5%.
Preparation method is that (1) extracting liquorice, Radix Sophorae Tonkinensis, Mirabilitum crystallina, Rhizoma Coptidis, Indigo Naturalis, calamitas urinae hominis, artificial Calculus Bovis, Margarita pulverize separately become fine powder; (2) in above ratio with above fine powder mixing, pulverize through jet mill, fineness is to become micropowder about 5 μ m; (3) with above micropowder and Borneolum Syntheticum and chitosan 15g, glycerol 80g, laurocapram 20g, ethanol 400ml, triethylamine alcohol 10g, purified water adds to 1000g, mixing, sterilization, gel.
Embodiment four
Borneolum Syntheticum 25%, Radix Glycyrrhizae 15%, Radix Sophorae Tonkinensis 10%, Mirabilitum crystallina 20%, Rhizoma Coptidis 15%, Indigo Naturalis 5%, calamitas urinae hominis 5%, Margarita 3%, artificial Calculus Bovis 2%.
Preparation method is that (1) extracting liquorice, Radix Sophorae Tonkinensis, Mirabilitum crystallina, Rhizoma Coptidis, Indigo Naturalis, calamitas urinae hominis, artificial Calculus Bovis, Margarita pulverize separately become fine powder; (2) in above ratio with above fine powder mixing, pulverize through jet mill, fineness is to become micropowder about 5 μ m; (3) with above micropowder and Borneolum Syntheticum, dimethyl sulfoxide 50ml, glycerol 150ml, ethanol (60%) adds to 1000ml mixing, sterilization, liniment.
Claims (5)
1, the application of a kind of Chinese medicine composition in the preparation Retinoids, Retin-A, Renova, Accutane, each set of dispense of described Chinese medicine composition is such as following:
Borneolum Syntheticum 10-50%, Radix Glycyrrhizae 10-50%, Radix Sophorae Tonkinensis 8-38%, Mirabilitum crystallina 2-25%, Rhizoma Coptidis 1-15%, Indigo Naturalis 0.5-5%, calamitas urinae hominis 0.5-5%, Margarita 1-3%, artificial Calculus Bovis 1-3%.
2, the application of a kind of Chinese medicine composition according to claim 1 in the preparation Retinoids, Retin-A, Renova, Accutane, each set of dispense ratio of described Chinese medicine composition is preferably as follows:
Borneolum Syntheticum 27.12%, Radix Glycyrrhizae 27.12%, Radix Sophorae Tonkinensis 18%, Mirabilitum crystallina 12.4%, Rhizoma Coptidis 9.04%, Indigo Naturalis 2.256%, calamitas urinae hominis 2.256%, Margarita 0.904%, artificial Calculus Bovis 0.904%.
3, the application of a kind of Chinese medicine composition according to claim 1 and 2 in the preparation Retinoids, Retin-A, Renova, Accutane is characterized in that the medicine of described treatment acne is said any exterior-applied formulation on the pharmaceutics.
4, the application of a kind of Chinese medicine composition according to claim 3 in the preparation Retinoids, Retin-A, Renova, Accutane is characterized in that described dosage form is ointment or cream or gel or liniment.
5, the method for preparing any described Retinoids, Retin-A, Renova, Accutane in the claim 1-4 is:
(1) Radix Glycyrrhizae, Radix Sophorae Tonkinensis, Mirabilitum crystallina, Rhizoma Coptidis, Indigo Naturalis, calamitas urinae hominis, artificial Calculus Bovis, the Margarita pulverize separately of getting certain proportioning becomes fine powder or with above fine powder mixing, pulverizes through jet mill, and fineness is to become micropowder about 1--10 μ m; (2) with above fine powder or micropowder and a certain amount of Borneolum Syntheticum and an amount of external-use substrate mixing, make said any exterior-applied formulation on the clinical acceptable pharmaceutics.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805806A (en) * | 2012-08-28 | 2012-12-05 | 韩非 | Medicine for treating acne, maintaining beauty and keeping young, and preparation method thereof |
| CN105362368A (en) * | 2015-06-15 | 2016-03-02 | 厦门医学高等专科学校 | Traditional Chinese medicine compound with acne removing function and preparation method and application thereof |
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| CN100336525C (en) * | 2005-04-06 | 2007-09-12 | 广东嘉应制药股份有限公司 | Medicinal composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805806A (en) * | 2012-08-28 | 2012-12-05 | 韩非 | Medicine for treating acne, maintaining beauty and keeping young, and preparation method thereof |
| CN102805806B (en) * | 2012-08-28 | 2013-09-11 | 韩非 | Medicine for treating acne, maintaining beauty and keeping young, and preparation method thereof |
| CN105362368A (en) * | 2015-06-15 | 2016-03-02 | 厦门医学高等专科学校 | Traditional Chinese medicine compound with acne removing function and preparation method and application thereof |
| CN105362368B (en) * | 2015-06-15 | 2019-06-14 | 厦门医学院 | A kind of herbal composite and its preparation method and application with acne-removal function |
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