CN100336525C - Medicinal composition - Google Patents

Abstract

The present invention discloses a medical composition which is prepared from raw medicinal materials of the following weight percentages: 10 to 50% of borneol, 10 to 50% of liquorice, 8 to 38% of vietnamese sophora root, 2 to 25% of gypsum rubrum, 1 to 15% of coptis, 0.5 to 5% of natural indigo and 0.5 to 5% of calamitas urinae hominis. The present invention has the functions of clearing heat, removing toxicity, eliminating swelling, alleviating pain, preventing corrosion and promoting tissue regeneration and is used for curing diseases such as swelling and pain in the throat, the erosion of the oral cavity, the pain of the gingiva, etc. caused by the intrinsic heat of the lung and the stomach. The present invention has obvious curing effects on acute pharyngitis, acute tonsillitis, the inflammation of the oral cavity and acute eczema caused by the excess heat and toxin of the lung and the stomach and is capable of obviously curing symptoms such as throat pain, swallow pain, the dried throat, poor appetite, thirst, bitter taste in the mouth, etc. and physical signs such as the inflammation of the pharyngeal portion, swelling of the tonsil, etc. The present invention is capable of also curing erythema on the buttocks of neonates, nasal blockade, crusted tetter, dermatophytosis, bedsore, canker, otitis externa, cervical erosion, etc.

Description

A kind of pharmaceutical composition

Technical field

The present invention relates to a kind of pharmaceutical composition, particularly a kind of pharmaceutical composition for the treatment of laryngopharynx swelling and pain, oral erosion, gingiva pain.

Background technology

Often because of due to the lung gastric heat poison, throat is under the lung stomach for laryngopharynx swelling and pain, oral erosion, its cause of disease of gingiva pain, and wind heat poison heresy is followed mouth and nose invasion lung system, throat stands in the breach, and evil poison is fought and tied in pharyngeal tonsils, so that venation is obstructed, sarolemma is burnt, and the red and swollen distending pain of pharyngeal tonsils forms laryngopharynx swelling and pain.Damp-heat in the spleen and stomach follows through last steaming oral cavity, burns to decrease sarolemma, and the QI and blood delay forms the oral cavity redness and festers.Excessiveness of stomach-fire follows through last steaming gums and forms gingiva pain, takes a broad view of above-mentioned all disease causes, and is all relevant with accumulated heat in the lung and stomach.Existing its therapeutic effect of medicine is not good enough, and curative effect is not obvious, and effective percentage is low.

Summary of the invention

Purpose of the present invention just provides a kind of have heat-clearing and toxic substances removing, reducing swelling and alleviating pain, erosion prevention and muscle growing function, can effectively treat the pharmaceutical composition of laryngopharynx swelling and pain, oral erosion, gingiva pain.

The present invention can be realized by following mode: the present invention is made by following raw material medicines in percentage by weight: Borneolum Syntheticum 10-50%, Radix Glycyrrhizae 10-50%, Radix Sophorae Tonkinensis 8-38%, Mirabilitum crystallina 2-25%, Rhizoma Coptidis 1-15%, Indigo Naturalis 0.5-5%, calamitas urinae hominis 0.5-5%.

Be preferably: Borneolum Syntheticum 27.3%, Radix Glycyrrhizae 27.3%, Radix Sophorae Tonkinensis 18.5%, Mirabilitum crystallina 12.9%, Rhizoma Coptidis 9.2%, Indigo Naturalis 2.4%, calamitas urinae hominis 2.4%.

Each amounts of components of medicine of the present invention can also be: Borneolum Syntheticum 10-50%, Radix Glycyrrhizae 10-50%, Radix Sophorae Tonkinensis 8-38%, Mirabilitum crystallina 2-25%, Rhizoma Coptidis 1-15%, Indigo Naturalis 0.5-5%, calamitas urinae hominis 0.5-5%, Margarita 1-3%, artificial Calculus Bovis 1-3%.

Be preferably: Borneolum Syntheticum 27.12%, Radix Glycyrrhizae 27.12%, Radix Sophorae Tonkinensis 18%, Mirabilitum crystallina 12.4%, Rhizoma Coptidis 9.04%, Indigo Naturalis 2.256%, calamitas urinae hominis 2.256%, Margarita 0.904%, artificial Calculus Bovis 0.904%.

Reuse Borneolum Syntheticum clearing away heat to alleviate pain, erosion prevention and muscle growing in the prescription of the present invention; Radix Glycyrrhizae heat-clearing and toxic substances removing, relieving spasm to stop pain; Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, clearing throat are monarch drug in the side altogether; The Mirabilitum crystallina clearing away heat-fire; Rhizoma Coptidis clearing away heat-fire, the hot-tempered temperature of detoxifying, Indigo Naturalis heat-clearing and toxic substances removing, removing heat from blood detumescence; Calamitas urinae hominis's clearing away heat-fire, removing heat from blood repercussive are ministerial drug in the side altogether; Margarita, artificial Calculus Bovis's heat-clearing and toxic substances removing granulation promoting are to be adjuvant drug; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, double think make.All medicines share, and the pyretic toxicity of lung stomach are got clearly, then all disease spontaneous recovery.This prescription collects multiple heat and toxic materials clearing away medicine in a side, so the power of its heat-clearing and toxic substances removing is very strong, thereby above-mentioned all diseases is had significant curative effect.

The present invention has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, erosion prevention and muscle growing function, is used for the disease such as laryngopharynx swelling and pain, oral erosion, gingiva pain due to the accumulated heat in the lung and stomach.The curative effect of the present invention acute pharyngitis due to flourishing, acute tonsillitis, oral inflammation, acute eczema to lung gastric heat poison has the curative effect of highly significant, can obviously improve have sore throat, signs such as symptom such as odynophagia, dry laryngopharynx, inappetence, thirsty bitter taste and pharyngeal inflammation, antiadoncus.In the clinical trial process, there is no obvious adverse reaction and malaise symptoms, illustrate that the present invention uses effectively clinically, safety.In addition, the present invention can also treat neonate buttocks erythema, stuffy nose, impetigo, beriberi, decubital ulcer, ulcer, otitis externa, cervical erosion etc.

1, animal acute toxicity test of the present invention

Medicine: medicine is provided by the applicant.

Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half, by the supply of Traditional Chinese Medicine University Of Guangzhou Experimental Animal Center, the quality certification number: Guangdong searching 2000A028, the moving word 26-2001A002 of doctor.

Method and result: 1) medicine preparation: the 11g spice is pulverized, is assigned to the 150g/L suspension with the normal saline that contains 2% Radix Acaciae senegalis, this moment medicinal liquid thickness to 9# syringe needle can suck reluctantly; 2) be spray larynx or buccal approach in view of clinical, the gastric infusion mode is adopted in experiment.Disposable administration, volume 0.2ml/10g body weight, close observation 8h also notes down, and continues to observe 7d; 3) mice does not have death among the 7d, and behavior is active, and food ration is as usual, and the hair color light does not have loose dirty, and nothing is fainted from fear drowsiness, and eye, mouth, nose, ear and the no abnormal secretions of crissum do not have the mashed toe of docking.Select 5 execution, finding of naked eye, important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes.Test also tests out mice through gastric infusion maximum dosage-feeding 3.0g/kg, and 1200 times of the clinical medicine doses of being equivalent to be grown up show no obvious abnormalities reaction and naked eyes pathological change, show the oral safety of this medicine.

2, animal mucosa irritation reaction of the present invention

Medicine: medicine is provided by the applicant.

Experimental animal: Cavia porcellus.

Method and result: 1) medicine preparation: with 100 times of medicated powder of clinical Coming-of-Age Day dosage, use dissolved in purified water, make suspension; 2) mark is pharyngeal inferior to spraying into Cavia porcellus in the 4h, continuous 14d (be equivalent to people's sprayed coating administration 3 medication cycle more than), observe animal part and general reaction, and carry out hematology, Liver and kidney biochemistry and important organ histopathologic examination, local and whole body is not seen obvious pathological reaction, and peripheral hemogram, Serum ALT and BUN and matched group be no significant difference relatively; Pathological replacement lung, stomach, the heart, liver, kidney all find no metasemy; 3) with 50 times and 25 times medicated powder of clinical Coming-of-Age Day dosage, make suspension with dissolved in purified water, it is pharyngeal repeatedly to spray into Cavia porcellus in the 4h, and animal does not see obvious pharynx---airway irritation symptom; The larynx of inspecting by ready samples behind 24h, 48h and the 7d, trachea and bronchial tissue, the pathological replacement mucosal epithelium is complete.

3, long-term toxicity test for animals medicine of the present invention

Medicine: medicine is provided by the applicant.

Animal: regular grade SD rat, body weight 21g ± 10g, male and female half and half are by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center supply, Guangdong Province State Scientific and Technological Commission laboratory animal monitoring institute's quality certification (Guangdong probatio inspectionem pecuoarem word) 2000A019 number, Guangdong Province's medical faunae administration commission certificate of competency (the moving word of doctor) 26-2001A001.

Method and result: 1) medicine preparation: divide high, medium and low three dosage groups, be respectively 300,150,75 times of clinical application amount, mix at 1: 1 with the normal saline that contains 2% Radix Acaciae senegalis; 2) be spray larynx or buccal approach in view of clinical, the gastric infusion mode is adopted in experiment, successive administration 24d, promptly more than 3 clinical cycles, observe the animal general toxic reaction and the order of severity, put to death the back and check each position, and carry out the hematology, the pathological examination of main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach by rule of operation; 3) long-term oral administration, toxic reaction does not appear in animal.Physically well develop.Naked eyes outward appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN and matched group relatively do not have pathologic and change.All not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach are thought to confirm that through pathology animal is not had poisoning manifestations.

4, animal pharmacodynamics test of the present invention

Experiment material: medicine is provided by the applicant, and every contains medicine 0.0125g/ sheet, is made into desired concn with distilled water during experiment, hereinafter to be referred as the acute throat trouble sheet, and lot number 911004.

Powder is provided by the applicant, is called for short acute throat trouble and looses lot number 910012.

Hydrocortisone-produce by Hubei Pharmaceutic Works, lot number 900605 (be called for short hydrogen can).

Laboratory animal: provide by Department of Health of Guangdong Province experimental animal feeding field.

Experimental technique and result:

(1) xylol causes the influence of mouse ear inflammatory reaction.

Method: selecting body weight for use is 60 of 18-22g healthy mices, and male and female are regardless of, are divided into five groups at random, press the 0.2ml/10g gastric infusion, and one day secondary was separated by 6 hours, continuous two days.After the last administration 1 hour, cause inflammation for mice left side ear melted paraxylene 0.05ml, 15 minutes with the disconnected cervical vertebra execution of mice, cut ears along the basal part of the ear, ear is laid along the thin edge of ear with card punch (0.7mm), weigh with the analysis Libra then, two ear weight differences are inflammation swelling degree, and the result learns by statistics to handle and sees Table 1.The influence of table 1 xylol induced mice ear inflammation

Group	The example number	Inflammation swelling degree (mg) X ± SD	Compare P with matched group
				Distilled water 2.1% acute throat trouble sheet 3.15% acute throat trouble sheet 3.15% acute throat trouble looses 0.25% hydrogen can	14 14 14 14 14	3.86±1.52 1.44±1.05 0.81±0.59 1.78±1.23 0.32±0.25	＜0.01 ＜0.01 ＜0.01 ＜0.01

(2) Dichlorodiphenyl Acetate causes the influence of the blue seepage discharge of mouse peritoneal ivens

Method: choosing body weight is 60 of 18-22g healthy mices, and male and female are regardless of, are divided into five groups at random, press the 0.2ml/10g gastric infusion, and one day secondary was separated by 6 hours, continuous two days.After the last administration 1 hour, blue normal saline solution 0.1ml/10g body weight of tail vein injection 0.5% ivens and lumbar injection 0.5% acetic acid 0.2ml/ are only, take off after 20 minutes cervical vertebra, put to death, cut the abdominal cavity open and draw flushing 3 times back and forth with normal saline, be collected in the 10ml test tube, add normal saline to the 10ml 200-10 of Hitachi type spectrophotometer=625nm mensuration OD value, the results are shown in Table 2.

Table 2 Dichlorodiphenyl Acetate causes the influence of the blue seepage discharge of mouse peritoneal ivens

Group	The example number	Dosage ml/10g body weight	Blue seepage discharge (OD value) X ± SD of ivens	Compare P with matched group
					Distilled water 2.1% acute throat trouble sheet 3.15% acute throat trouble sheet 3.15% acute throat trouble looses 0.25% hydrogen can	14 14 14 14 14	0.2 0.2 0.2 0.2 0.2	0.096±0.010 0.083±0.015 0.075±0.007 0.083±0.008 0.079±0.009	＜0.05 ＜0.01 ＜0.01 ＜0.01

(3) cotton balls is caused the influence that the rat granuloma forms

Method: choosing body weight is 50 of 100-150g healthy rats, five groups are regardless of, are divided at random to male and female, with 1% barbital 0.3ml/100g body weight, the intraperitoneal injection of anesthesia rat, what nuzzle 20mg under the sterilization situation in the back is soaked with one of mycillin mixed liquor cotton balls, sew up wound (operation back mycillin mixed liquor sterilization wound once a day * 3 day, in case infect).Postoperative 2 hours beginning medication once a day, was put to death animal in 1 hour behind continuous seven days, last administration, took out granuloma induced by implantation of cotton pellets, oven dry in 12 hours in 60 ℃ of baking ovens, and weighing deducts the former weight of cotton balls and promptly gets granuloma weight, the results are shown in Table 3.

The granulomatous influence of table 3 pair rat

Group	The example number	Dosage ml/10g body weight	Blue seepage discharge (OD value) X ± SD of ivens	Compare P with matched group
					Distilled water 2.1% acute throat trouble sheet 3.15% acute throat trouble sheet 3.15% acute throat trouble looses 0.25% hydrogen can	14 14 14 14 14	2 2 2 2 2	72.47±7.47 57.69±5.57 60.65±3.87 65.04±5.55 35.63±2.67	＜0.01 ＜0.01 ＜0.05 ＜0.01

(4) PARA FORMALDEHYDE PRILLS(91,95) causes the influence of ankle swelling in rat

Method: choosing body weight is 125 of 100-150g healthy SD rats, and male and female are regardless of, are divided into five groups at random, press 2ml/100g body weight gastric infusion, causes inflammation in the left back ankle joint of rat subcutaneous injection 3% formaldehyde 0.1ml simultaneously.The results are shown in Table 4.

The influence of table 4 PARA FORMALDEHYDE PRILLS(91,95) rat ankle arthroncus

Group	The example number	Dosage ml/10 body weight g	Ankle swelling degree CM behind the medicine
							First day		Second day
			X±SD	P	X±SD	P
							Distilled water 2.1% acute throat trouble sheet 3.15% acute throat trouble sheet 3.15% acute throat trouble looses 0.25% hydrogen can	14 14 14 14 14	2 2 2 2 2	0.149±0.020 0.126±0.021 0.124±0.028 0.115±0.033 0.091±0.015	＜0.01 ＜0.01 ＜0.01 ＜0.01	0.144±0.038 0.088±0.024 0.077±0.030 0.086±0.024 0.064±0.021	＜0.01 ＜0.01 ＜0.01 ＜0.01

Annotate: the P value refers to compare with matched group

More than the prompting of four experimental results: the acute throat trouble buccal tablet can significantly suppress the inflammatory reaction of mice caused by dimethylbenzene xylene ear; Acetic acid causes the blue seepage discharge of mouse peritoneal ivens, cotton balls causes the formation of rat granuloma and formaldehyde causes the rat ankle joint inflammatory reaction, compare P＜0.01-0.05 with matched group, illustrate that the acute throat trouble buccal tablet has good antiinflammation, the acute throat trouble of its antiinflammation and dose,equivalent looses relatively.

(1) cause in two of the blue seepage discharges of mouse peritoneal ivens suppressing the inflammatory reaction of dimethylbenzene mouse ear and suppress acetic acid, extra quality acute throat trouble buccal tablet is stronger than SHANGLIAOHOUFENG SAN, P＜0.05.

(2) cause in two of the rat ankle arthritis reactions suppressing granuloma induced by implantation of cotton pellets and suppress formaldehyde, extra quality acute throat trouble buccal tablet and SHANGLIAOHOUFENG SAN do not have significant difference, P＞0.05

5, the clinical observation on the therapeutic effect of medicine composite for curing laryngopharynx swelling and pain, oral erosion, gingiva pain

The present invention observes 374 routine patients' clinical trial through four tame hospitals such as the first attached institute of Traditional Chinese Medicine University Of Guangzhou, Guangzhou institute of traditional Chinese medicine, Guangdong Province second institute of traditional Chinese medicine, Guangdong Province's Meizhou City the People's Hospitals, wherein: and acute pharyngitis 98 examples; Acute tonsillitis 97 examples; Oral inflammation 98 examples; Acute eczema 81 examples.It is the contrast medicine that SANJIN XIGUA SHUANG is selected in clinical trial for use, and objective evaluation the present invention treats the clinical efficacy and the safety thereof of diseases such as laryngopharynx swelling and pain due to the flourishing card of lung gastric heat poison and oral erosion, gingivitis, nasal sinuses abscess, skin ulceration.The result shows:

The acute pharyngitis comparability detects and shows: two groups of sexes, age, the course of disease, the pasts treat, have sore throat, aspects such as symptom and sign such as odynophagia, dry laryngopharynx, throat burning sensation, hoarseness, inappetence, thirsty and bitter taste, stool, urine, body temperature, pharyngeal inflammation, antiadoncus and body of the tongue, tongue fur, pulse condition relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

From efficacy analysis as can be known, treatment group clinical recovery rate is 27.6%, and obvious effective rate is 20.4%, and effective percentage is 51.0%, and total effective rate is 99.0%, and inefficiency is 1.0%; Matched group clinical recovery rate is 17.5%, and obvious effective rate is 19.0%, and effective percentage is 60.3%, and total effective rate is 96.8%, and inefficiency is 3.2%.Credit is analysed by statistics, clinical efficacy there was no significant difference between two groups, and prompting treatment group curative effect is suitable with matched group.Treat after five days, the treatment group to improvement have sore throat, the symptom of odynophagia and the effect that alleviates pharyngeal inflammation be better than matched group, difference has significance.

The acute tonsillitis comparability detects and shows: two groups of sexes, age, the course of disease, the pasts treat, have sore throat, symptom and sign such as dry laryngopharynx, throat burning sensation, hoarseness, odynophagia, inappetence, thirsty and bitter taste, body temperature, pharyngeal inflammation, antiadoncus and stool relatively, difference there are no significant meaning; Aspects such as body of the tongue, tongue fur, pulse condition are there was no significant difference relatively; Only urine has significant difference.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

From efficacy analysis as can be known, treatment group clinical recovery rate is 42.3%, and obvious effective rate is 35.1%, and effective percentage is 21.6%, and total effective rate is 99.0%, and inefficiency is 1.0%; Matched group clinical recovery rate is 28.8%, and obvious effective rate is 35.6%, and effective percentage is 30.5%, and total effective rate is 94.9%, and inefficiency is 5.1%.Credit is analysed by statistics, clinical efficacy there was no significant difference between two groups, and prompting treatment group curative effect is suitable with matched group.The treatment group to have sore throat, the improvement of sign such as symptom such as odynophagia, dry laryngopharynx, inappetence, thirsty bitter taste and pharyngeal inflammation, antiadoncus is better than matched group.

The oral inflammation comparability detects and to show: two groups of sexes, age, the course of disease, previously treatment, and body temperature, ulcer number, ulcer size, ulcer pain degree, herpes pain degree; Aspects such as symptom such as xerostomia, inappetence, feed difficulty, gingiva hyperemia and body of the tongue, tongue fur, pulse condition relatively, difference there are no significant meaning; And bitter taste, halitosis are relatively, and significant difference is arranged.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

From efficacy analysis as can be known, treatment group clinical recovery rate is 63.3%, and obvious effective rate is 16.3%, and effective percentage is 16.3%, and total effective rate is 95.9%, and inefficiency is 4.1%; Matched group clinical recovery rate is 53.6%, and obvious effective rate is 12.5%, and effective percentage is 21.4%, and total effective rate is 87.5%, and inefficiency is 12.5%.Two groups of therapeutic equivalences; To the improvement of symptom, sign, two groups of effects are suitable substantially, and only the improvement effect treatment group to bitter taste is better than matched group, and difference has significant difference.

The acute eczema comparability detects and to show: two groups of sexes, age, the course of disease, previously treatment, and aspects such as symptom such as body temperature, erythra distribution, erythra form, dry mouth with bitter taste, inappetence, defecation and body of the tongue, tongue fur relatively, difference there are no significant meaning; Only pruritus degree, pulse condition have significant difference.The principal element that prompting influences two groups of curative effects has harmony substantially, shows that two groups have comparability.

From efficacy analysis as can be known, treatment group clinical recovery rate is 18.5%, and obvious effective rate is 35.8%, and effective percentage is 43.2%, total effective rate is 97.5%, and inefficiency is 2.5%; Matched group clinical recovery rate is 17.7%, and obvious effective rate is 23.5%, and effective percentage is 47.1%, and total effective rate is 88.3%, and inefficiency is 11.7%.Credit is analysed by statistics, clinical efficacy there was no significant difference between two groups, and prompting treatment group curative effect is suitable with matched group.Two groups suitable to the effect that improves symptom, sign, and difference does not have significance.

Safety detects and shows: to routine blood test, routine urinalysis, stool routine examination, liver function (GPT), renal function (BUN), the Electrocardiographic detection of some cases.Laboratory detected unusually before treatment group and matched group all had the part patient, and the check of treatment back recovers normally.Bad clinical symptoms does not all appear after all case medications.

In sum, the curative effect of medicine of the present invention acute pharyngitis due to flourishing, acute tonsillitis, oral inflammation, acute eczema to lung gastric heat poison is suitable with contrast medicine GUILIN XIGUA SHUANG, but to have sore throat, the improvement of sign such as symptom such as odynophagia, dry laryngopharynx, inappetence, thirsty bitter taste and pharyngeal inflammation, antiadoncus is better than matched group, difference has the significance meaning.In the clinical trial process, there is no obvious adverse reaction and malaise symptoms, illustrate that medicine of the present invention is used effectively clinically, safety.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described.

Embodiment one

Get 27.3 kilograms of Borneolum Syntheticums, 27.3 kilograms of Radix Glycyrrhizaes, 18.5 kilograms of Radix Sophorae Tonkinensiss, 12.9 kilograms of Mirabilitum crystallinas, 9.2 kilograms of Rhizoma Coptidis, 2.4 kilograms of Indigo Naturaliss, 2.4 kilograms of calamitas urinae hominises and be ground into fine powder; With above each fine powder mixing, powder.

Embodiment two

Get 20 kilograms of Borneolum Syntheticums, 20 kilograms of Radix Glycyrrhizaes, 8 kilograms of Radix Sophorae Tonkinensiss, 25 kilograms of Mirabilitum crystallinas, 15 kilograms of Rhizoma Coptidis, 5 kilograms of Indigo Naturaliss, 5 kilograms of calamitas urinae hominises, 1 kilogram of artificial Calculus Bovis and be ground into fine powder; 1 kilogram of Margarita water is flown into fine powder; With above each fine powder mixing, powder.

Embodiment three

Get 30 kilograms of Radix Glycyrrhizaes, 12 kilograms of Radix Sophorae Tonkinensiss, 10 kilograms of Mirabilitum crystallinas, 11 kilograms of Rhizoma Coptidis, 2 kilograms of Indigo Naturaliss, 2 kilograms of calamitas urinae hominises, 1.1 kilograms of Margarita pulverize separately of 1.1 kilograms of artificial Calculus Boviss and become fine powder; With above fine powder mixing, to pulverize through jet mill, fineness is to become micropowder about 5 μ m; With micropowder and an amount of lactose, mannitol, maltodextrin and correctives mixing, granulation, 50-60 ℃ of drying; 30.8 kilograms of Borneolum Syntheticums are dissolved in the ethanol in proportion, spray into above granule, airtight, add lubricant after, tabletting tablet.

Embodiment four

Get 27.12 kilograms of Radix Glycyrrhizaes, 18 kilograms of Radix Sophorae Tonkinensiss, 12.4 kilograms of Mirabilitum crystallinas, 9.04 kilograms of Rhizoma Coptidis, 2.256 kilograms of Indigo Naturaliss, 2.256 kilograms of calamitas urinae hominises, 0.904 kilogram of artificial Calculus Bovis and become fine powder with 0.904 kilogram of Margarita pulverize separately; with above fine powder mixing; add that proper auxiliary materials is granulated, 60 ℃ of dryings, granulate, cross the 130-150 mesh sieve; add 27.12 kilograms of Borneolum Syntheticum fine powders and lubricant, incapsulate.

Claims (4)

1, a kind of pharmaceutical composition is characterized in that it mainly being to be made by following raw material medicines in percentage by weight: Borneolum Syntheticum 10-50%, Radix Glycyrrhizae 10-50%, Radix Sophorae Tonkinensis 8-38%, Mirabilitum crystallina 2-25%, Rhizoma Coptidis 1-15%, Indigo Naturalis 0.5-5%, calamitas urinae hominis 0.5-5%.

2, pharmaceutical composition according to claim 1 is characterized in that the crude drug percentage by weight is: Borneolum Syntheticum 27.3%, Radix Glycyrrhizae 27.3%, Radix Sophorae Tonkinensis 18.5%, Mirabilitum crystallina 12.9%, Rhizoma Coptidis 9.2%, Indigo Naturalis 2.4%, calamitas urinae hominis 2.4%.

3, pharmaceutical composition according to claim 1 is characterized in that wherein crude drug also has: Margarita 1-3%, artificial Calculus Bovis 1-3%.

4, pharmaceutical composition according to claim 3 is characterized in that the crude drug percentage by weight is: Borneolum Syntheticum 27.12%, Radix Glycyrrhizae 27.12%, Radix Sophorae Tonkinensis 18%, Mirabilitum crystallina 12.4%, Rhizoma Coptidis 9.04%, Indigo Naturalis 2.256%, calamitas urinae hominis 2.256%, Margarita 0.904%, artificial Calculus Bovis 0.904%.