CN106619767A - Medicine composition for treating dairy cow mastitis as well as preparation method and application thereof - Google Patents
Medicine composition for treating dairy cow mastitis as well as preparation method and application thereof Download PDFInfo
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- CN106619767A CN106619767A CN201611255871.3A CN201611255871A CN106619767A CN 106619767 A CN106619767 A CN 106619767A CN 201611255871 A CN201611255871 A CN 201611255871A CN 106619767 A CN106619767 A CN 106619767A
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- goldenrod
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a medicine composition for treating dairy cow mastitis. The medicine composition is prepared from the following raw material medicines in parts by weight: 1 to 3 parts of periplaneta Americana and 1 to 3 parts of solidago virgaurea. The invention further provides a preparation method and the application of the medicine composition. By compatible use of the periplaneta Americana and the solidago virgaurea, the medicine composition is used for treating the dairy cow mastitis, develops the synergistic interaction, has an obvious medicinal effect, is safe to use, does not have side effect, and provides a new medicine application choice for clinical treatment.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for treating mastitis for milk cows, belongs to field of veterinary.
Background technology
Mastitis is the inflammation caused by cause pathogeny imcrobe infection mammary gland essence, interstitial and substantive interstitial.Traditionally claim
For mammitis.Milk bovine mastitis is caused by two class pathogenic microorganisms, and a class is that infectious pathogenic microorganisms (are called Niu Yi
Bad venereal disease pathogenic microorganism) such as：Staphylococcus aureus, Streptococcusagalactiae etc.；Another kind of is that condition pathogenic microorganism (is called environment
Venereal disease pathogenic microorganism) such as：Escherichia coli, citric acid seedling, streptococcus uberis etc..Mammitis has I clinic mastitis and Asia to face
The two kinds of performances of bed-type mammitis.I clinic mastitis, the lighter's milk is thin, and color is in canescence, there is floccule, and breast pain is not
Substantially, milk production declines substantially, and constitutional symptom is not obvious：Severe one breast area's swelling, erythrosis, quality is hard, and substantially, breast is produced pain
Amount is reduced sharply, and color is in light gray, and body temperature is raised, and lymphonodi supramammarici swelling such as walnut is big：Pole severe one.Appetite is useless exhausted, and body temperature raises 41
More than DEG C, delay many days, heartbeat 100 times, more than point, lactation stops.Breast is as hard as flint, and skin sends out infantile malnutrition due to digestive disturbances or intestinalparasites, cracking, pain, only
A small amount of yellow liquid is extruded from breast.Mammitis is one of incidence of disease highest disease in cow disease.It is particularly recessive
Mammitis is extremely complex disease, despite years of researches, but still is that one of most diseases are spent in milk cows.
The development of animal husbandry also depends on the magical effect of antibiotic, and especially under the conditions of large-scale cultivation, livestock and poultry can only
Health care and disease treatment are carried out by artificial technical measures.But Long-Time Service antibiotic can make some floras be changed into antibody-resistant bacterium,
And drug-resistance factor can be passed to sensitive bacterial by antibody-resistant bacterium. make other xenogenesis bacterial strains be changed into antibody-resistant bacterium, so as to give preventing and treating
The disease of people, animal brings difficulty, and has constituted to the sanitarian relative side of body. the presence to above-mentioned situation.People grind in discussion
The special antibiotic of feed processed.Focus mostly at present in polypeptide (bacitracin, sulphur Tai rhzomorphs), phosphoric acid polysaccharide (flavomycoin) and poly-
The development of ethers (coban, draw husky star rhzomorph, salinomycin) etc. and use.
American cockroach (Periplanetaamericana L.) is Arthropoda Insecta Blattaria Blattidae
(Blattidae) Periplaneta (Peripalneta) insect, is commonly called as cockroach, is to multiply one of most strong insect of power in the world. America
Big Lian is distributed widely in the ground such as Guangdong, Guangxi, Guizhou, Fujian, Yunnan, Sichuan in China. as traditional Chinese medicine, American cockroach tool
There is long history of being used as medicine, be recorded in earliest《Sheng Nong's herbal classic》, referred to as roach is honest and clean, is listed as middle product, and taste cold in nature is salty, poisonous, has
Acid, have the scattered stasis of blood, disappear the functions such as product, removing toxic substances, Li Shui, detumescence.Cure mainly infantile malnutrition, tonsillitis, body enclosed mass, ulcerative carbuncle to swell
Pain and centipede, venomous snake bite etc..
Goldenrod (Solidagocanadensis L.) is composite family, Solidago, originates in Chinese East China, Central-South
And the ground such as southwest.The whole nation has 4 kinds, and Zhejiang has 2 kinds, as Solidago Canadensis (CanadaGoldenrop) and goldenrod
(CommonGoldenrop).Solidago Canadensis is adventive, and weeds are easily generated after introducing a fine variety, and is malignant weed.And one
Branch chrysanthemum is indigenous plant, also known as sweet vernal grass, king all over the mountain, hundred with grass etc., what is be discussed herein is the goldenrod of this local products.Herb
Be used as medicine, nature and flavor are pungent, hardship, tepor, can wind and heat dispersing, anti-inflammation, for catching a cold, acute laryngopharyngitis, tonsillitis, boil swell
Poison, and have hypotensive effect.
The pertinent literature for using both American cockroach, goldenrod compatibility is there is no to report at present.
The content of the invention
The technical scheme is that there is provided a kind of pharmaceutical composition for treating mastitis for milk cows.Another skill of the present invention
Art scheme there is provided the preparation method and purposes of the pharmaceutical composition.
The invention provides a kind of pharmaceutical composition for treating mastitis for milk cows, it is by the bulk drug of following weight proportioning
It is prepared from：
American cockroach 1-3 parts, goldenrod 1-3 parts.
It is further preferred that it is prepared from by the bulk drug of following weight proportioning：
2 parts of American cockroach, 2 parts of goldenrod.
Pharmaceutical composition of the present invention is to be by American cockroach, the primary medicinal powder of goldenrod, water or extractive with organic solvent
Active component, adds pharmaceutically acceptable auxiliary material or complementary composition to be prepared into pharmaceutically conventional preparation.
Wherein, described preparation is oral formulations, ejection preparation.
Present invention also offers a kind of method for preparing described pharmaceutical composition, it comprises the steps：
A, the bulk drug for weighing each weight proportion；
B, add water or Solvent Extract methods, add pharmaceutically acceptable auxiliary material or complementary composition is prepared into pharmaceutically
Conventional preparation.
Wherein, described organic solvent is ethanol.
Present invention also offers purposes of the pharmaceutical composition in the herbal medicine for preparing treatment mastitis for milk cows.
Medicine material American cockroach of the present invention, goldenrod compatibility are used, and for treating mastitis for milk cows, have played collaboration
Synergistic effect, drug effect substantially, using safety, has no side effect, and provides a kind of new medication for clinic and selects.
Specific embodiment
The preparation of the medicine of the present invention of embodiment 1
American cockroach 1000g (A), American cockroach 500g are taken respectively：Goldenrod 500g (B), goldenrod 1000g (C)
In right amount, plus 30 times of ethanol amount, decoct 2 times, each 1h, filter, merging filtrate, be concentrated into relative density for 1.13～1.15 (60
～70 DEG C) clear cream, add ethanol to cause whole content for 75%, filter precipitation, filtrate recycling ethanol adds water to 500ml, places
48 hours, filtration, filtrate adjusted pH value to 6.5 with 10% sodium hydroxide solution, injects water to 1000ml, mixes, then Jing
After activated carbon process, refrigeration is filtered, embedding, and sterilizing is obtained final product.
The preparation of the medicine of the present invention of embodiment 2
American cockroach 1000g, goldenrod 3000g are taken, is prepared by the method for embodiment 1.
The preparation of the medicine of the present invention of embodiment 3
American cockroach 3000g, goldenrod 1000g are taken, is prepared by the method for embodiment 1.
Beneficial effects of the present invention are proved below by way of concrete pharmacodynamics test.
The clinical drug application of the present invention of test example 1
Mammitis milk cow 100 is suffered from selection, and 4 groups are divided at random, and wherein D groups are Benzylpenicillin sodium salt therapeutic test group；A、B、C
Group (being prepared by embodiment 1) is perfusion liquid therapeutic test group.Continuous use 3～7 days, by test, compares each group milk after medication
The treatment cycle of ox, cure rate.
1. test method
The selection of 1.1 clinic mastitis milk cows possesses following symptom or partial symptoms person is diagnosable for clinical type breast
It is scorching：A. breast volume increase, heating, quality are hardened；B. skin of breast is rubescent, and palpation has pain；C. Ge Ru areas are not of uniform size, breast
Room superior gluteal lymph node enlargement；D. milk discoloration, sticky, floccule, ziega, clot etc. occur abnormal.
1.2 therapeutic schemes
D groups：Intramuscular injection Benzylpenicillin sodium salt, 2～30,000 units/kgs, daily 2 times, the course for the treatment of 7 days.
A, B group：By every cow head per breast room perfusion 10ml (per 1ml crude drug in whole containing 1g), daily administration 2 times, the course for the treatment of 7 days.
1.3 efficacy determination methods
Cure：Clinical symptom disappearance, milk directly perceived is without exception, and milk yield recovers substantially, and SMT methods testing result is less than " ++ "
To cure.
Take a turn for the better：Clinical symptom relief or disappearance.There is a small amount of floccule in milk, but milk color and luster is without exception.Yield fails
Recover normal, SMT method testing results are remained above " ++ ".
It is invalid：Each clinical symptoms in criterion do not mitigate or aggravate.
It is efficient：Efficient=(cure+effectively)/total case load * 100%.
1.4 results
Clinical Treatment Test result of each test group of table 1 to mastitis for milk cows
Result of the test shows that drug infusion liquid of the present invention is compared with Benzylpenicillin sodium salt with single perfusion liquid, to mastitis for milk cows
There is more preferably therapeutic effect, not only efficient height, and cure rate is also high.
Claims (7)
1. a kind of pharmaceutical composition for treating mastitis for milk cows, it is characterised in that：It is by the bulk drug system of following weight proportioning
It is standby to form：
American cockroach 1-3 parts, goldenrod 1-3 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that：It is prepared by the bulk drug of following weight proportioning
Form：
2 parts of American cockroach, 2 parts of goldenrod.
3. pharmaceutical composition according to claim 1 and 2, it is characterised in that：It is by the original of American cockroach, goldenrod
Crude drug powder, water or extractive with organic solvent are active component, add pharmaceutically acceptable auxiliary material or complementary composition to be prepared into
The preparation pharmaceutically commonly used.
4. pharmaceutical composition according to claim 3, it is characterised in that：Described preparation is oral formulations, ejection preparation.
5. a kind of method for preparing the pharmaceutical composition described in claim 1-4 any one, it comprises the steps：
A, the bulk drug for weighing each weight proportion；
B, add water or Solvent Extract methods, add pharmaceutically acceptable auxiliary material or complementary composition is prepared into and pharmaceutically commonly uses
Preparation.
6. preparation method according to claim 5, it is characterised in that：Described organic solvent is ethanol.
7. the pharmaceutical composition described in claim 1-4 any one prepare treatment mastitis for milk cows herbal medicine in use
On the way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611255871.3A CN106619767A (en) | 2016-12-30 | 2016-12-30 | Medicine composition for treating dairy cow mastitis as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611255871.3A CN106619767A (en) | 2016-12-30 | 2016-12-30 | Medicine composition for treating dairy cow mastitis as well as preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106619767A true CN106619767A (en) | 2017-05-10 |
Family
ID=58837660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611255871.3A Pending CN106619767A (en) | 2016-12-30 | 2016-12-30 | Medicine composition for treating dairy cow mastitis as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619767A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743741A (en) * | 2012-05-06 | 2012-10-24 | 大理学院 | Preparation of blattodea polypeptide, and uses of the same in anti-gram-positive bacteria and anti-gram-negative bacteria |
-
2016
- 2016-12-30 CN CN201611255871.3A patent/CN106619767A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743741A (en) * | 2012-05-06 | 2012-10-24 | 大理学院 | Preparation of blattodea polypeptide, and uses of the same in anti-gram-positive bacteria and anti-gram-negative bacteria |
Non-Patent Citations (1)
| Title |
|---|
| 杨卫平等: "《新编中草药图谱及常用配方（三）》", 31 January 2010, 贵州科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170510 |