CN103720927A - Traditional Chinese medicine preparation for treating dairy cow mastitis - Google Patents
Traditional Chinese medicine preparation for treating dairy cow mastitis Download PDFInfo
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- CN103720927A CN103720927A CN201310568753.8A CN201310568753A CN103720927A CN 103720927 A CN103720927 A CN 103720927A CN 201310568753 A CN201310568753 A CN 201310568753A CN 103720927 A CN103720927 A CN 103720927A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating dairy cow mastitis. The preparation is prepared from 11 active ingredients, namely, musk, flos chrysanthemi indici, dandelion, red flowers, herba violae, venenum bufonis, folium isatidis, coptis chinensis, herba andrographitis, pangolin and herba houttuyniae. The preparation contains various bioactive components, such as alkaloid, glycosides, organic acid an the like, is easy to absorb and free of toxic and side effects, has effects of clearing heat, removing toxicity, resisting bacteria, diminishing inflammation, simulating the menstrual flow, activating blood, removing swelling, relieving carbuncle, activating collaterals and promoting lactation, and has a good treatment effect on the dairy cow mastitis.
Description
Technical field
the invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of bovine mastitis and preparation method thereof.
Background technology
since reform and opening-up, people's living standard obviously improves, and milk becomes people's daily life permanent stores.The increase of milk demand is exceedingly fast the development of raising dairy cattle industry; refuse incomplete statistics; current national milch cow is over 1,500 ten thousand; yet China's aquaculture scientific management level is low; take extensive operation as main; the ratio that milch cow suffers from mastitis (as acute, chronic, hemorrhagic, suppurative and bacillary mastitis) is very high, and milk crop and quality and milk cow health have been caused to very big impact.
at present, in actual raising, bovine mastitis is used antibiotic to treat mostly, and its short run effect is remarkable, but effect is unstable, easily recurrence, and in milk, easily contain antibiotic remains, unfavorable to human health.
china's tradition veterinary applications is called acute mastitis by clinical type bovine mastitis, thinks on " healthy energy foot, heresy can not be done ".Carcass because of positive QI-insufficiency be subject to pathogenic microorganism invasion pyrogenicity, stop up contain breast mutually knot, newborn network be obstructed and form disease, there is red and swollen hot carbuncle, putrid milk, the secretion symptoms such as depressed, fervescence that reduce, wriggle.In evil poison, invade the heat-transformation of aquatic weeds knot, newborn network is smooth, milk is stagnant or nipple destroys, bacterium is taken advantage of a weak point, mammary gland is subject to physics, chemistry, microorganism intense stimulus and breast local inflammation occurs changes.Therefore, mastitis should take heat-clearing and toxic substances removing, anti-inflammation, restore menstrual flow and invigorate blood circulation, reducing swelling and alleviating pain, active lactogenesis be Therapeutic Principle.
thus, Chinese medicine will be a best point of penetration of seeking suitable bovine mastitis healing potion.And, Chinese medicine preparation and animal feed homology consubstantiality, aspect metabolism, there is the incomparable advantages of medicine such as chemical drugs, antibiotic, hormones, after use, conventionally can not contain drug residue, have no side effect or toxic and side effects little, its metabolite can be absorbed or get rid of external by animal, become crop organic fertilizer material, can be to environment.
Summary of the invention
object of the present invention is just to provide a kind of natural Chinese medicines preparation for the treatment of bovine mastitis, by 11 taste crude drug such as Moschus, Flos Chrysanthemi Indici, Herba Taraxaci, Flos Carthami, Herba Violae, Venenum Bufonis, Folium Isatidis, Rhizoma Coptidis, Herba Andrographis, Squama Manis, Herba Houttuyniae, be prepared from, said preparation is containing multiple bioactive ingredients such as alkaloid, glycoside, organic acid, easily absorb, have no side effect, there is heat-clearing and toxic substances removing, anti-inflammation, restore menstrual flow and invigorate blood circulation, subside a swelling and stop the effect of carbuncle, active lactogenesis, bovine mastitis is had to good therapeutic effect.
the Chinese medicine preparation for the treatment of bovine mastitis of the present invention, in weight portion, is prepared from by following crude drug:
moschus: 0.8 Flos Chrysanthemi Indici: 50 Herba Taraxacis: 60
flos Carthami: 20 Herba Violaes: 50 Venenum Bufoniss: 2
folium Isatidis: 30 Rhizoma Coptidis: 15 Squama Maniss: 40
herba Andrographis: 50 Herba Houttuyniae: 40.
the preparation method of the Chinese medicine preparation of above-mentioned treatment bovine mastitis of the present invention, comprises the following steps:
1) the 11 taste crude drug such as Moschus, Flos Chrysanthemi Indici, Herba Taraxaci, Flos Carthami, Herba Violae, Venenum Bufonis, Folium Isatidis, Rhizoma Coptidis, Herba Andrographis, Squama Manis, Herba Houttuyniae cleaned, clean, be dried, be ground into coarse powder, weigh by weight subsequently and add in extraction pot, add subsequently crude drug weight 8-12 purified water doubly, be heated to boil, decoct 3 hours, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) herb liquid extracts for the second time: in extraction pot, add crude drug weight 6-10 purified water doubly, and be heated to boil, decoct 2 hours, medicinal liquid is leached, obtain filtrate for the second time, and standby;
3) herb liquid extracts for the third time: in extraction pot, add crude drug weight 4-6 purified water doubly, be heated to boil, decoct 1 hour, medicinal liquid is leached, obtain filtrate for the third time, and standby;
4) by step 1 to 3 standby for the first time, for the second time, filtrate is placed in container and is uniformly mixed for the third time, precipitation, filters, and obtains filtrate, standby;
5) step 4 gained filtrate is concentrated by Chinese medicinal steaming hair device, be concentrated into 2/5ths of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 1 times of weight, carry out precipitate with ethanol 72 hours, then by separation of ethanol, obtain fluid extract for the first time; Add the ethanol of the content 95% of 0.8 times of weight to carry out precipitate with ethanol 48 hours first-class extractum, then separating alcohol, obtains fluid extract for the second time; Add the ethanol of the content 95% of 0.7 times of weight to carry out precipitate with ethanol 24 hours fluid extract for the second time, and then separation of ethanol, obtain fluid extract, standby;
7) the standby fluid extract of step 6 gained is adjusted to pH value to 4.6～6.0 with sodium hydroxide, then at 120 ℃, carry out high temperature sterilize 30 minutes, obtain the Chinese medicine preparation for the treatment of bovine mastitis of the present invention.
the Chinese medicine preparation for the treatment of bovine mastitis of the present invention is brown clear liquid, and gas is fragrant, bitter in the mouth, has good stability and safety.This Chinese medicine preparation can mode oral or injection be used, and preferably the mode of injection is as intravenous injection, focal zone injection (being that nipple breast pond is injected) and intravenous drip.When adopting focal zone injection, by aiming at nipple milk ejection hole sphincter after the injection nozzle sterilization of syringe, medicinal liquid is injected to newborn pond.
chinese medicine preparation of the present invention includes the multiple bioactive ingredients such as alkaloid, glycoside, organic acid and trace element, the mastitis pathogenic bacteriums such as streptococcus dysgalactiae, streptococcus agalactiae, staphylococcus aureus, escherichia coli, Serratieae, Bacillus proteus, staphylococcus are had to very strong inhibition or killing action, mammary gland swelling, lump due to all kinds of mastitis there are quick detumescence dissipating blood stasis, the dredging collateral that relieves the pain, diuretic eliminating stagnation, promote to recover milking capacity, increase and exempt from short effect more, and easy to operate, economical and practical, curative effect is high, has no side effect.
The specific embodiment
preparation Example
preparation process:
1) the 11 taste crude drug such as Moschus, Flos Chrysanthemi Indici, Herba Taraxaci, Flos Carthami, Herba Violae, Venenum Bufonis, Folium Isatidis, Rhizoma Coptidis, Herba Andrographis, Squama Manis, Herba Houttuyniae cleaned, clean, be dried, be ground into coarse powder, take respectively Moschus 0.8kg, Flos Chrysanthemi Indici 50kg, Herba Taraxaci 60kg, Flos Carthami 20kg, Herba Violae 50kg, Venenum Bufonis 2kg, Folium Isatidis 30kg, Rhizoma Coptidis 15kg, Squama Manis 40kg, Herba Andrographis 50kg and Herba Houttuyniae 40kg, add in extraction pot, add 3500kg purified water, be heated to boil, decoct 3 hours, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) herb liquid extracts for the second time: in extraction pot, add 2700kg purified water, be heated to boil, decoct 2 hours, medicinal liquid is leached, obtain filtrate for the second time, and standby;
3) herb liquid extracts for the third time: in extraction pot, add 1700kg purified water, be heated to boil, decoct 1 hour, medicinal liquid is leached, obtain filtrate for the third time, and standby;
4) by step 1 to 3 standby for the first time, for the second time, filtrate is placed in container and is uniformly mixed for the third time, precipitation, filters, and obtains filtrate, standby;
5) step 4 gained filtrate is concentrated by Chinese medicinal steaming hair device, be concentrated into 2/5ths of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 1 times of weight, carry out precipitate with ethanol 72 hours, then by separation of ethanol, obtain fluid extract for the first time; Add the ethanol of the content 95% of 0.8 times of weight to carry out precipitate with ethanol 48 hours first-class extractum, then separating alcohol, obtains fluid extract for the second time; Add the ethanol of the content 95% of 0.7 times of weight to carry out precipitate with ethanol 24 hours fluid extract for the second time, and then separation of ethanol, obtain fluid extract, standby;
7) the standby fluid extract of step 6 gained is adjusted to pH value to 6.0 with sodium hydroxide, then at 120 ℃, carry out high temperature sterilize 30 minutes, must treat the Chinese medicine preparation of bovine mastitis.
effect embodiment
the milch cow that suffers from mastitis of take is object, and the therapeutic effect of above-mentioned Chinese medicine preparation is carried out to clinical trial.
, experiment material
(1) Chinese medicine preparation of the treatment bovine mastitis that above-mentioned Preparation Example obtains;
(2) experimental animal:
from milk cattle cultivating community, new street, outskirts of a town township, Beian City, choose 160 milch cows that suffer from mastitis, the typical disease of these milch cows is: newborn district has obviously inflammation red, swollen, hot, pain to show, lethargy, inappetence, milk is rare clearly, jaundice with obvious floccule, and milk yield is starkly lower than healthy cow of the same age.
, experimental technique
above-mentioned 160 cow heads are divided into 4 groups at random, are respectively 45 of 45 of small dose group, 45 of middle dosage groups, heavy dose of groups, 25 of matched groups, each organizes medication and method as following table:
medication group continuous use, every day periodic monitor milch cow situation, disease and the situation of change of giving milk, according to the change judgement curative effect of clinical symptoms and milk.Cure, effective and invalid criterion is as follows:
cure: newborn district is red, swollen, hot, pain disappears, milch cow spirit, appetite is normal, and milk perusal is normal, and milk yield returns to healthy cow level of the same age.
effective: newborn district is red, swollen, hot, pain obviously alleviates, and appetite is recovered to some extent, and milk floccule substantially disappears or obviously reduces, and milk yield is gone up.
invalid: newborn district is red, swollen, hot, pain nothing obviously alleviates, lethargy, inappetence, milk is clear rare or jaundice still, and flocculus is still more obvious.
, experimental result
small dose group is in medication after 10 days, and milch cow is spiritual, appetite is normal, and milk perusal is normal, and milk yield is recovered, and milch cow is all fully recovered.Middle dosage group is in medication after 7 days, and milch cow is spiritual, appetite is normal, and milk perusal is normal, and milk yield is recovered, and milch cow is all fully recovered.Heavy dose of group is in medication after 6 days, and milch cow is spiritual, appetite is normal, and body condition is clearly better, lots of natural fleshing, and milk perusal is normal, and milk yield is recovered, and milch cow is all fully recovered.
the milch cow of matched group is red, swollen, hot in experimentation Zhong Ru district, pain situation is obvious, lethargy, inappetence, and milk is rare clearly, jaundice and with flocculus, symptom is all the time without significant change.
, conclusion
the Chinese medicine preparation for the treatment of bovine mastitis of the present invention has good therapeutic effect to bovine mastitis, can make the milch cow that suffers from mastitis recover Milk Production, to improving the sound development of milk production of cow and quality, promotion dairy, has very positive effect.
above example of the present invention is had been described in detail, but described content is only preferred embodiments of the present invention, can not be considered to for limiting practical range of the present invention.All equalization variations of doing according to the present patent application scope and improvement etc., all should belong to patent covering scope of the present invention.
Claims (2)
1. treat a Chinese medicine preparation for bovine mastitis, in weight portion, by following crude drug, be prepared from:
Moschus: 0.8 Flos Chrysanthemi Indici: 50 Herba Taraxacis: 60
Flos Carthami: 20 Herba Violaes: 50 Venenum Bufoniss: 2
Folium Isatidis: 30 Rhizoma Coptidis: 15 Squama Maniss: 40
Herba Andrographis: 50 Herba Houttuyniae: 40.
2. described in claim 1, treat the preparation method of the Chinese medicine preparation of bovine mastitis, comprise the following steps:
1) the 11 taste crude drug such as Moschus, Flos Chrysanthemi Indici, Herba Taraxaci, Flos Carthami, Herba Violae, Venenum Bufonis, Folium Isatidis, Rhizoma Coptidis, Herba Andrographis, Squama Manis, Herba Houttuyniae cleaned, clean, be dried, be ground into coarse powder, weigh by weight subsequently and add in extraction pot, add subsequently crude drug weight 8-12 purified water doubly, be heated to boil, decoct 3 hours, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) herb liquid extracts for the second time: in extraction pot, add crude drug weight 6-10 purified water doubly, and be heated to boil, decoct 2 hours, medicinal liquid is leached, obtain filtrate for the second time, and standby;
3) herb liquid extracts for the third time: in extraction pot, add crude drug weight 4-6 purified water doubly, be heated to boil, decoct 1 hour, medicinal liquid is leached, obtain filtrate for the third time, and standby;
4) by step 1 to 3 standby for the first time, for the second time, filtrate is placed in container and is uniformly mixed for the third time, precipitation, filters, and obtains filtrate, standby;
5) step 4 gained filtrate is concentrated by Chinese medicinal steaming hair device, be concentrated into 2/5ths of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 1 times of weight, carry out precipitate with ethanol 72 hours, then by separation of ethanol, obtain fluid extract for the first time; Add the ethanol of the content 95% of 0.8 times of weight to carry out precipitate with ethanol 48 hours first-class extractum, then separating alcohol, obtains fluid extract for the second time; Add the ethanol of the content 95% of 0.7 times of weight to carry out precipitate with ethanol 24 hours fluid extract for the second time, and then separation of ethanol, obtain fluid extract, standby;
7) the standby fluid extract of step 6 gained is adjusted to pH value to 4.6～6.0 with sodium hydroxide, then at 120 ℃, carry out high temperature sterilize 30 minutes, obtain the Chinese medicine preparation for the treatment of bovine mastitis of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310568753.8A CN103720927A (en) | 2013-11-15 | 2013-11-15 | Traditional Chinese medicine preparation for treating dairy cow mastitis |
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| CN201310568753.8A CN103720927A (en) | 2013-11-15 | 2013-11-15 | Traditional Chinese medicine preparation for treating dairy cow mastitis |
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| CN103720927A true CN103720927A (en) | 2014-04-16 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106293A (en) * | 2015-09-15 | 2015-12-02 | 临汾市尧都区傲康养殖发展有限公司 | Traditional Chinese medicine composition for milk cow mastitis |
| CN106267193A (en) * | 2016-09-27 | 2017-01-04 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of for infusion of medicine agent treating bovine mastitis and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277049A (en) * | 1999-06-11 | 2000-12-20 | 郭增才 | Medicine for treating breast tumor and carbuncle |
| CN102512547A (en) * | 2011-12-14 | 2012-06-27 | 赵兴友 | Traditional Chinese medicine composition for treating canine distemper virus and preparation method thereof |
-
2013
- 2013-11-15 CN CN201310568753.8A patent/CN103720927A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277049A (en) * | 1999-06-11 | 2000-12-20 | 郭增才 | Medicine for treating breast tumor and carbuncle |
| CN102512547A (en) * | 2011-12-14 | 2012-06-27 | 赵兴友 | Traditional Chinese medicine composition for treating canine distemper virus and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 连学昭: "防治奶牛乳房炎新型中药制剂的研究", 《中国优秀博硕士学位论文全文数据库 (硕士) 农业科技辑》, no. 8, 15 August 2006 (2006-08-15) * |
| 马保臣: "奶牛乳腺炎的研究", 《中国优秀博硕士学位论文全文数据库 (硕士) 农业科技辑》, no. 3, 15 September 2003 (2003-09-15) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105106293A (en) * | 2015-09-15 | 2015-12-02 | 临汾市尧都区傲康养殖发展有限公司 | Traditional Chinese medicine composition for milk cow mastitis |
| CN106267193A (en) * | 2016-09-27 | 2017-01-04 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of for infusion of medicine agent treating bovine mastitis and its preparation method and application |
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Application publication date: 20140416 |