CN103860749B - A kind of preparation method treating the sick Chinese medicine composition of Ungula Sus domestica and Chinese medicine thereof - Google Patents
A kind of preparation method treating the sick Chinese medicine composition of Ungula Sus domestica and Chinese medicine thereof Download PDFInfo
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- CN103860749B CN103860749B CN201410101554.0A CN201410101554A CN103860749B CN 103860749 B CN103860749 B CN 103860749B CN 201410101554 A CN201410101554 A CN 201410101554A CN 103860749 B CN103860749 B CN 103860749B
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Abstract
The present invention relates to animal medicine, field of veterinary, be specifically related to a kind of preparation method treating the sick Chinese medicine composition of Ungula Sus domestica and Chinese medicine thereof. The Chinese medicine composition that treatment Ungula Sus domestica is sick, is made up of Flos Lonicerae 2～5 parts, Radix Isatidis 2～5 parts, Radix Angelicae Sinensis 1～4 part, Radix Scrophulariae 2～5 parts, Fructus Forsythiae 2～5 parts, 1～3 part of Flos Carthami, Rhizoma Chuanxiong 1～3 part and 1～3 part of Radix Glycyrrhizae. Medical material is mixed, pulverizes, add pure water post-heating reflux, extract; Extracting solution is concentrated, adds ethanol and carry out precipitate with ethanol; Precipitate with ethanol supernatant concentration containing effective ingredient is reclaimed ethanol, and concentrated solution carries out adsorption bleaching process; Regulate the pH value of adsorption bleaching treatment fluid, sequentially add tween 80, benzyl alcohol, filter after mix homogeneously; Add water for injection to adjust medicinal liquid active constituent content, subpackage, sterilizing. Chinese medicine can be used for treating Ungula Sus domestica portion swelling pain, stasis of blood purple, blister that the various cause of disease causes, festers, sand crack, limb hoof deformation etc.
Description
Technical field
The present invention relates to animal medicine, field of veterinary, be specifically related to a kind of Chinese medicine composition treating Ungula Sus domestica disease, meanwhile, the preparation method that the invention also discloses the sick Chinese medicine of this treatment Ungula Sus domestica.
Background technology
In recent years, the development of China pig industry is swift and violent, the introduction of pig kind and the improvement of land race, improves the lean meat percentage of pig and produces performance. But the incidence rate that Ungula Sus domestica is sick and mortality are all significantly higher, it has also become one of serious epidemic disease, hamper the development of pig industry. Ungula Sus domestica disease is a non-specific disease syndrome of class, Different types of etiopathogenises the hoof caused infringement is feature, and clinical manifestation is that affected pig happiness is sleeping, dysstasia, easily falls down, haunch when standing, joint is purple to hoof swelling, the stasis of blood, or the deformation of coronet abscess, sand crack, limb hoof, hypertrophy or ulceration. Serious sick pig owing to handicapped or sleeping not rising, squeeze not Shang groove and become thin, exhaustion, or secondary decubital ulcer and generate heat, how because of exhaustion, septicemia and extremely.
Causing Ungula Sus domestica disease pathogenic factor a lot, such as kind inherited genetic factors, nutrition is unbalanced or grows too fast, and column home is narrow or ground is firmly sliding, pig limitation of movement, and sanitary condition is bad, and pathogenic bacteria multiplies, and the chronic poisoning of selenium, fluorosis, arsenic compound are poisoning. Also have a lot of infectiousness, infectious disease, suffer from antibacterial, the viral diseases such as pig erysipelas, Streptococcus suis, polyarthritis, brucellosis, encephalitis B and foot and mouth disease such as pig, all can show arthroncus clinically, the symptom such as limb hoof festers, limping.
At present both at home and abroad that Ungula Sus domestica is sick preventing and treating, mainly from Cultivars, improve feeding and management and prevented. Treat mainly around invading centered by the pathogen of local infection, adopt antibiotherapy or chemotherapy, as injected penicillin, florfenicol, antondin, procaine etc., local is coated with YUSHIZHI RUANGAO, chlorotetracycline ointment, zinc ointment or potassium permanganate solution cleaning etc.
But, antibiotic, disinfectant and narcotic analgesic medicine, secondary infection and alleviating pain can only be prevented. To the hoof swelling having resulted in, the stasis of blood is purple, the infringements such as necrosis of festering, and the regeneration of the dysbolismus etc. of body and reparation not effect, so curative effect is often notable, the mortality suffering from hoof disease pig at present is still significantly high.
Summary of the invention
In order to overcome the shortcoming part existed in above-mentioned prior art, one of the technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition treating Ungula Sus domestica disease. The two of the technical problem to be solved in the present invention are to provide the production method of the sick Chinese medicine of a kind for the treatment of Ungula Sus domestica containing above-mentioned Chinese medicine composition.
For one of technical problem solving the present invention, the technical scheme adopted is: a kind of Chinese medicine composition treating Ungula Sus domestica disease, is made up of the raw material of following weight portion:
Preferably, the Chinese medicine composition that treatment Ungula Sus domestica is sick, it is made up of the raw material of following weight portion:
The Chinese medicine composition of the treatment Ungula Sus domestica disease of the present invention, in side, Flos Lonicerae, Radix Isatidis, Fructus Forsythiae have antibacterial, antiviral and anti-inflammatory analgetic effect; Flos Lonicerae join Fructus Forsythiae again can dispelling wind and heat pathogens, expelling pathogenic factors from the exterior is gone out; Radix Scrophulariae purging fire and cooling blood, removing dampness and killing parasites, share with Fructus Forsythiae can hard masses softening and resolving; Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, dredge the meridian passage, promote congestive edema to dissipate, fresh bloodization is raw, is conducive to healing and the reparation of tissue; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, again can removing summer-heat pyretic toxicity, QI invigorating tissue regeneration promoting. Radix Angelicae Sinensis, Flos Carthami energy blood-supplementing blood-nourishing in side, the cloudy liquid of Radix Scrophulariae nourishing, Radix Glycyrrhizae QI invigorating. Full side strengthening vital QI to eliminate pathogenic factors, eliminates sufferer and does not hinder again healthy energy, benefiting vital QI and blood and do not hold back heresy.
The Chinese medicine composition that the treatment Ungula Sus domestica of the present invention is sick, adopts and has heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, the Chinese prescription of removing heat from blood eliminating stagnation, and dredging the meridian is inaccessible, eliminates coagulation of QI-blood, promotes tissue metabolism, the regeneration of local and reparation, makes the rapid rehabilitation of ill pig.
In order to solve the two of the technical problem of the present invention, the technical scheme adopted is: the preparation method of the Chinese medicine of the treatment Ungula Sus domestica disease containing above-mentioned Chinese medicine composition, and including decoction and alcohol sedimentation technique, step is as follows:
1., medical material mixed, pulverize, addition pure water post-heating reflux, extract;
2., extracting solution is concentrated, add ethanol and carry out precipitate with ethanol;
3., the precipitate with ethanol supernatant concentration containing effective ingredient being reclaimed ethanol, concentrated solution carries out adsorption bleaching process;
4., the pH value of adsorption bleaching treatment fluid is regulated to 7.3～7.5, sequentially add tween 80, benzyl alcohol, filter after mix homogeneously;
5., add water for injection and reach 6～12g crude drug/ml, subpackage, sterilizing to adjust medicinal liquid active constituent content.
Preferably, described step 1. in the fineness of pulverizing medicinal materials be 10～20 orders.
Preferably, described step 1. in reflux, extract, time addition is medical material weight 10～14 times of pure water.
Preferably, described step 1. in time of reflux, extract, be 20～50min, extraction time is 1～3 time.
Preferably, described step 2. in concentrated solution add ethanol make the alcohol content of mixed solution reach 60～80%, the number of times of precipitate with ethanol is 1～3 time.
Preferably, described step 3. in adsorption bleaching process be the heating activated carbon adsorption bleaching 15～45min adding its weight 0.1～0.5% in concentrated solution.
Preferably, described step 4. in pH value regulator be sodium hydroxide, the addition of tween 80 be preparation injection weight 0.5～1%, the addition of benzyl alcohol be preparation injection weight 1～2%.
Preferably, described step 4. in filtration be mixed liquor is sequentially passed through G4, G5, G6 sintered glass funnel filter, described step 5. in addition water for injection carry out in G6 sintered glass funnel.
The preparation method of the Chinese medicine of the treatment Ungula Sus domestica disease of the present invention, production stage is simple, raw material is cheap and easy to get, is suitable for industrialized production, and actual application value is high. The Chinese medicine of preparation can be used for treating Ungula Sus domestica portion swelling pain, stasis of blood purple, blister that the various cause of disease causes, festers, sand crack, limb hoof deformation etc. Can individually inject use, it is possible to coordinate antibiotics, analgesic to use together with the disinfectant of local. The case that antibiotics, disinfectant therapeutic effect is bad, uses this injection to remain to effective. Consumption is 50～100kg/2ml, intramuscular injection, 1～2 times/day, the recovery from illness in 2 days of general mild, the serious symptom can not stood, medication can freely be walked for 3～5 days, and cure rate reaches more than 98%, therefore, the Chinese medicine of the present invention, instant effect, recovers fast, greatly reduces the mortality of disease pig.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, but the present invention is not limited only to these embodiments, and under the premise without departing from present inventive concept, any improvement made all falls within protection scope of the present invention.
Buy from market or prepare following raw materials according according to prior art:
Flos Lonicerae, Radix Isatidis, Radix Angelicae Sinensis, Radix Scrophulariae, Fructus Forsythiae, Flos Carthami, Rhizoma Chuanxiong, Radix Glycyrrhizae, pure water, ethanol, tween 80, benzyl alcohol, water for injection, activated carbon, sodium hydroxide, sintered glass funnel (G4, G5, G6).
Embodiment 1
Flos Lonicerae 3 parts, Radix Isatidis 3 parts, Radix Angelicae Sinensis 2 parts, Radix Scrophulariae 3 parts, Fructus Forsythiae 2 parts, 1.5 parts of Flos Carthami, Rhizoma Chuanxiong 1.5 parts and 1 part of mixed powder of Radix Glycyrrhizae are broken into 20 orders, add the pure water of medical material amount 14 times, soak 20min, heating and refluxing extraction 40min, collect supernatant. Medicinal residues add the pure water of medical material amount 10 times, heating and refluxing extraction 30min again, collect supernatant, merge with first time extracting solution.
Extracting solution is concentrated into the 1:1～1:2 of medical material amount, adds ethanol and makes alcohol content reach 60%, stands 24 hours, takes supernatant, reclaims ethanol, and concentrated medicament is to the 1:1～1:2 of medical material, then adds ethanol and make alcohol content reach 80%; Stand 24 hours, take supernatant, reclaim ethanol concentrated medicament.
Adding 0.3% heating activated carbon absorption 30min in the medicinal liquid of concentration, filter, filtrate hydro-oxidation sodium solution adjusts pH to 7.4, sequentially adds 0.8% tween 80,1.2% benzyl alcohol, mixing.
Filtering through G4, G5, G6 sintered glass funnel successively, add water for injection in G6 sintered glass funnel, adjusting medicinal liquid is 9g crude drug/ml, subpackage, and sterilizing must treat the Chinese medicine that Ungula Sus domestica is sick.
Embodiment 2
Proportioning is: Flos Lonicerae 2 parts, Radix Isatidis 3 parts, Radix Angelicae Sinensis 4 parts, Radix Scrophulariae 2 parts, Fructus Forsythiae 2 parts, 3 parts of Flos Carthami, Rhizoma Chuanxiong 3 parts, 1 part of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
Proportioning is: Flos Lonicerae 5 parts, Radix Isatidis 2 parts, Radix Angelicae Sinensis 1 part, Radix Scrophulariae 5 parts, Fructus Forsythiae 5 parts, 1 part of Flos Carthami, Rhizoma Chuanxiong 1 part, 3 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4
Proportioning is: Flos Lonicerae 2 parts, Radix Isatidis 5 parts, Radix Angelicae Sinensis 1 part, Radix Scrophulariae 5 parts, Fructus Forsythiae 2 parts, 1 part of Flos Carthami, Rhizoma Chuanxiong 3 parts, 3 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Claims (10)
1. treat the Chinese medicine composition that Ungula Sus domestica is sick, be made up of the raw material of following weight portion:
2. the Chinese medicine composition that treatment Ungula Sus domestica according to claim 1 is sick, is characterized in that being made up of the raw material of following weight portion:
3. the method utilizing the Chinese medicine of Chinese medicine composition as claimed in claim 1 or 2 preparation treatment Ungula Sus domestica disease, including decoction and alcohol sedimentation technique, is characterized in that step is as follows:
1., medical material mixed, pulverize, addition pure water post-heating reflux, extract;
2., extracting solution is concentrated, add ethanol and carry out precipitate with ethanol;
3., the precipitate with ethanol supernatant concentration containing effective ingredient being reclaimed ethanol, concentrated solution carries out adsorption bleaching process;
4., the pH value of adsorption bleaching treatment fluid is regulated to 7.3～7.5, sequentially add tween 80, benzyl alcohol, filter after mix homogeneously;
5., add water for injection and reach 6～12g crude drug/ml, subpackage, sterilizing to adjust medicinal liquid active constituent content.
4. the preparation method of the Chinese medicine that treatment Ungula Sus domestica according to claim 3 is sick, it is characterised in that: described step 1. in the fineness of pulverizing medicinal materials be 10～20 orders.
5. the preparation method of the Chinese medicine that treatment Ungula Sus domestica according to claim 3 is sick, it is characterised in that: described step 1. in reflux, extract, time addition is medical material weight 10～14 times of pure water.
6. the preparation method of the Chinese medicine that treatment Ungula Sus domestica according to claim 5 is sick, it is characterised in that: described step 1. in time of reflux, extract, be 20～50min, extraction time is 1～3 time.
7. the preparation method of the Chinese medicine that treatment Ungula Sus domestica according to claim 3 is sick, it is characterised in that: described step 2. in concentrated solution, add ethanol make the alcohol content of mixed solution reach 60～80%, the number of times of precipitate with ethanol is 1～3 time.
8. the preparation method of the Chinese medicine that treatment Ungula Sus domestica according to claim 3 is sick, it is characterised in that: described step 3. in adsorption bleaching to process be the heating activated carbon adsorption bleaching 15～45min adding its weight 0.1～0.5% in concentrated solution.
9. the preparation method of the Chinese medicine that treatment Ungula Sus domestica according to claim 3 is sick, it is characterized in that: described step 4. in pH value regulator be sodium hydroxide, the addition of tween 80 is the 0.5～1% of the injection weight of preparation, and the addition of benzyl alcohol is the 1～2% of the injection weight of preparation.
10. the preparation method of the Chinese medicine that treatment Ungula Sus domestica according to claim 3 is sick, it is characterized in that: described step 4. in filtration be mixed liquor is sequentially passed through G4, G5, G6 sintered glass funnel filter, described step 5. in addition water for injection carry out in G6 sintered glass funnel.
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Citations (2)
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|---|---|---|---|---|
| CN101244146A (en) * | 2008-02-22 | 2008-08-20 | 辽宁职业学院 | Method for preparing Chinese medicine injection for treating high-pathogenicity blue-ear disease of pig |
| CN103385914A (en) * | 2013-06-26 | 2013-11-13 | 山东无棣精盐厂 | Hot compress salt and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244146A (en) * | 2008-02-22 | 2008-08-20 | 辽宁职业学院 | Method for preparing Chinese medicine injection for treating high-pathogenicity blue-ear disease of pig |
| CN103385914A (en) * | 2013-06-26 | 2013-11-13 | 山东无棣精盐厂 | Hot compress salt and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 四妙勇安汤合桃红四物汤治疗脉管炎;杨志辉等，;《湖北中医杂志》;20031231;第25卷(第11期);第41页 * |
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Effective date of registration: 20171117 Address after: 233000 Anhui city of Bengbu Province River Industrial Park Jin Mo Chonglu Huaishang District No. 2 Patentee after: Anhui Heng Yuan pharmaceutcal corporation, Ltd Address before: 233100 east suburb, east suburb of mussel mountain, Bengbu, Anhui 2, unit 13, East 203, China Patentee before: Anhui Science and Technology University |
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