CN103751429A - Traditional Chinese medicine composition for treating bovine mastitis - Google Patents
Traditional Chinese medicine composition for treating bovine mastitis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for the treatment of bovine mastitis. The composition is prepared from 9 Chinese medicinal materials including radix bupleuri, Chinese violet, dandelion, wild chrysanthemum flower, forsythia, herba andrographis, pangolin, musk and toad venom. The composition contains a plurality of biological active ingredients including alkaloids, glycosides and organic acids, has the same source with the feed, easiness for absorption and no toxic or side effect, has the effects of clearing heat, detoxifying, resisting bacteria, relieving inflammation, stimulating the menstrual flow, invigorating blood circulation, subsiding swelling, relieving carbuncle, activating channels and promoting lactation, and can promote animal growth and development and enhance the immunity of animals.
Description
Technical field
the invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of bovine mastitis and preparation method thereof.
Background technology
in recent years, the particularly milk cattle cultivating develop rapidly of rural culture industry, raising people and scale are increasing/large.But, raise and lack standardized management, directly cause in raising dairy cattle disease occurred frequently.
mastitis, comprise acute, chronic, hemorrhagic, suppurative, fungoid mastitis, are one of diseases the most common in raising dairy cattle, prevalence nearly 1/3, clinical manifestation has: the milk in ill newborn district goes out flocculus, and grumeleuse is water sample sometimes, and breast has red, swollen, hot, pain symptom in various degree; Fervescence, pulse is accelerated, and spirit is depressed, poor appetite or absolutely useless, milk yield declines etc. rapidly.As treated and will have a strong impact on Milk quality and milk yield, harm humans and milk cow health not in time.Current, the multiplex antibiotic therapy of bovine mastitis, but effect is unstable, easily recurrence, and easily cause milk antibiotic to pollute, directly harm humans health.
Summary of the invention
the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of bovine mastitis, by 9 taste crude drug such as Radix Bupleuri, Herba Violae, Herba Taraxaci, Flos Chrysanthemi Indici, Fructus Forsythiae, Herba Andrographis, Squama Manis, Moschus, Venenum Bufoniss, be prepared from.Said composition is containing various bioactivators such as alkaloid, glycoside, organic acid, with feedstuff homology consubstantiality, easily absorb, have no side effect, there is heat-clearing and toxic substances removing, anti-inflammation, the only effect of carbuncle, active lactogenesis restores menstrual flow and invigorates blood circulation, subsides a swelling, and can promote animal individual growth promoter, strengthen animal immune ability.
the Chinese medicine composition for the treatment of bovine mastitis of the present invention, is comprised of A component and B component, and wherein, A component is prepared from by the crude drug of following weight portion:
radix Bupleuri: 10 Herba Violaes: 50 Herba Taraxacis: 60
flos Chrysanthemi Indici: 50 Fructus Forsythiaes: 30 Herba Andrographis: 50;
b component is prepared from by the crude drug of following weight portion:
moschus: 0.8 Venenum Bufonis: 2 Squama Maniss: 40.
the preparation method of the Chinese medicine composition of above-mentioned treatment bovine mastitis, comprises the following steps:
one, Radix Bupleuri, Herba Violae, Herba Taraxaci, Flos Chrysanthemi Indici, Fructus Forsythiae, Herba Andrographis, Squama Manis, Moschus, Venenum Bufonis 9 taste crude drug are cleaned, clean, dry, pulverize into coarse powder, weigh by weight, standby;
two, the preparation of A component:
1) Radix Bupleuri, Herba Violae, Herba Taraxaci, Flos Chrysanthemi Indici, Fructus Forsythiae and Herba Andrographis are added in extraction pot, inject the purified water of 8-12 times of weight of above-mentioned 6 taste medicines, be heated to boil, decoct 3 hours, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) herb liquid extracts for the second time: in extraction pot, inject the purified water of 6-10 times of weight of above-mentioned 6 taste medicines, be heated to boil, decoct 2 hours, medicinal liquid is leached, obtain filtrate for the second time, and standby;
3) herb liquid extracts for the third time: in extraction pot, inject the purified water of 4-6 times of weight of above-mentioned 6 taste medicines, be heated to boil, decoct 1 hour, medicinal liquid is leached, obtain filtrate for the third time, and standby;
4) by standby to step 1, step 2, step 3 for the first time, for the second time, filtrate is placed in container and is uniformly mixed for the third time, precipitation, filters, and obtains filtrate, standby;
5) step 4 gained filtrate is concentrated by Chinese medicinal steaming hair device, be concentrated into 2/5ths of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, then by separation of ethanol, fluid extract for the first time; Add the ethanol of the content 95% of 0.8 times of weight to carry out precipitate with ethanol 48 hours fluid extract for the first time, then separating alcohol, fluid extract for the second time; Add the ethanol of the content 95% of 0.7 times of weight to carry out precipitate with ethanol 24 hours fluid extract for the second time, and then separation of ethanol, the crude drug extractum that obtains preparing, i.e. A component;
three, the preparation of B component:
1) Moschus, Venenum Bufonis and Squama Manis are added in ultrasonic extracting machine, inject above-mentioned 3 taste medicine weight 8-12 purified water doubly, open vacuum automatic switch, be decompressed to negative pressure 0.5-1.5MP, and be heated to 40 ℃-50 ℃, at the ultrasonic 40-50 minute of 200MHz-300MHz, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) ultrasonic extraction for the second time: in ultrasonic extracting machine, inject above-mentioned 3 taste medicine weight 6-16 purified water doubly, open vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to 40 ℃-50 ℃, at the ultrasonic 30-40 minute of 300MHz-500MHz, medicinal liquid is leached, obtain filtrate for the second time, standby;
3) ultrasonic extraction for the third time: in ultrasonic extracting machine, inject above-mentioned 3 taste medicine weight 4-6 purified water doubly, open vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to 40 ℃-50 ℃, at 400MHz-500MHz ultrasonic 1 hour, medicinal liquid is leached, obtain filtrate for the third time, standby;
4) by standby to step 1, step 2, step 3 for the first time, for the second time, filtrate is placed in container stirring and evenly mixing for the third time;
5) step 4 gained medicinal liquid is concentrated by Chinese medicinal steaming hair device, be concentrated into 15% of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 3 times of weight, insert in alcohol precipitation tank, 80 ℃ of standing medicinal liquids filter after 80 hours again, get rid of medicinal residues;
7) decompression recycling ethanol, filters with filter paper after recovery ethanol again, then at 120 ℃, carries out high temperature sterilize filtrate 30 minutes, obtains B component;
four, A component and B component mixed and stirred, with sodium hydroxide, adjusting pH value to 4.6～6.0, then at 120 ℃, carrying out high temperature sterilize 30 minutes, must treat the Chinese medicine composition that bovine mastitis is used.
the ultrasonic extracting machine using in the present invention is the efficient extracter of GL being provided by Jining Tian Hua ultrasonic electronic Instrument Ltd., and described vacuum automatic switch is that the EN40-1AS Nene being provided by Shanghai Chi Cheng automation equipment company limited can vacuum automatic switch.
it is larger that decocting method extracts Moschus, Squama Manis and Venenum Bufonis herb liquid damage amount.In the present invention, use ultrasonic extraction technique to extract Moschus, Squama Manis and Venenum Bufonis herb liquid.Ultrasound wave is a kind of high number mechanical wave, has the effect of cavitation, pulverizing, stirring in liquid medium, by the cell that destroys vegetable drug, effective ingredient in medical material is dissolved in solvent, thereby can reach the object of extracting herb liquid.Chinese medicine ultrasonic extraction technological temperature low (40-50 ℃ conventionally), safety is good, can not destroy the medicinal ingredient with thermally labile, facile hydrolysis or oxidation characteristic, and extraction yield and efficiency are high.
chinese medicine composition of the present invention is colourless or micro-yellow clear liquid, can mode oral or injection use, and preferably the mode of injection is as intravenous injection, focal zone injection (being that nipple breast pond is injected) and intravenous drip.
clinical trial shows, Chinese medicine composition of the present invention has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, carbuncle and ulcer speed are received, the effect of active lactogenesis, various mastitis pathogenic bacteriums are had to very strong killing action, can reconcile, improve the interior environment of newborn gland cistern, destroy pathogen metabolic process, cause pathogen metabolism to be obstructed, thus kill pathogenic bacteria.This medicine can also improve body to the endotoxic tolerance of pathogen, and antagonism bacterial exotoxin, to body pessimal stimulation, reduces the damage of cell, alleviates toxemia synptom; Fibrosis mammary gland glandular cell is had and activates and activate its vigor, promote inflammatory or fibrosis product solution absorption, recover the effect of its milking capacity.
indication: this product has good curative effect to all kinds of mastitis of the animals such as milch cow, sheep, pig, comprising:
1, acute mastitis: suddenly fever is more than 40 ℃ in several hours to suffer from poultry, and breast part breast district or the enlargement suddenly of whole breast, touch breast very hard, flexibility decrease, Pi Wen increases and has a burning sensation.Pain reaction weight.The district's lactogenic of swelling breast stops, and only has the yellow water sample exudate of a small amount of inflammatory or a small amount of curdling piece to discharge during milking.
, hemorrhagic mastitis: suffer from carcass temperature rise or normal, poor appetite, the newborn district of part or whole breast swelling, touch and suffer from poultry pain reaction sensitivity, the livid purple color of breast surface, lactogenic stops, and has blood sample milk in various degree or thinner blood and slime sample inflammatory exudate during milking, sometimes with blood clot and red curdling piece, discharges.
, chronic mastitis: suffer from poultry and mostly be the normal or slight fever of body temperature.Touching breast has in various degree large lump as hard sense or children's's head, and lactation amount declines, and milk is thin or become micro-yellow, sometimes has curdling piece or cellulose sample coagulum to discharge.Extruding breast is suffered from district slight pain.
, fibroid mastitis: this kind of mastitis are acute mastitiss, because Therapeutic Method is improper or invalid by the Drug therapy of unsatisfactory curative effect many days, make mammary gland glandular cell for a long time in inflammatory edema wet face state, a large amount of Fibrin exudations, and be gathered in glandular cell, cause glandular cell's degeneration.Make pathological changes glandular cell fibrosis and lose milking capacity.Finally cause mammary gland atrophy, milking capacity significantly declines, and forms inclined to one side breast.
, suppurative mastitis: these type of mastitis be suppuration bacterium infect due to.This medicine has the abscess of inhibition to form to suppurative mastitis initial infection, the effect that swelling is disappeared.To the established case of abscess, can around suppuration kitchen range, form protection network, stop the effect of pathogen to external diffusion.
The specific embodiment
preparation Example
preparation process:
one, Radix Bupleuri, Herba Violae, Herba Taraxaci, Flos Chrysanthemi Indici, Fructus Forsythiae, Herba Andrographis, Squama Manis, Moschus, Venenum Bufonis 9 taste crude drug cleaned, clean, be dried, be ground into coarse powder, take respectively Radix Bupleuri 10kg, Herba Violae 50kg, Herba Taraxaci 60kg, Flos Chrysanthemi Indici 50kg, Fructus Forsythiae 30kg, Herba Andrographis 50kg, Moschus 0.8kg, Venenum Bufonis 2kg, Squama Manis 40kg, standby;
two, the preparation of A component:
1) Radix Bupleuri, Herba Violae, Herba Taraxaci, Flos Chrysanthemi Indici, Fructus Forsythiae and Herba Andrographis are added in extraction pot, inject 2050kg purified water, be heated to boil, decoct 3 hours, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) herb liquid extracts for the second time: in extraction pot, inject 1640kg purified water, be heated to boil, decoct 2 hours, medicinal liquid is leached, obtain filtrate for the second time, and standby;
3) herb liquid extracts for the third time: in extraction pot, inject 1025kg purified water, be heated to boil, front boiling 1 hour, leaches medicinal liquid, obtains filtrate for the third time, standby;
4) by standby to step 1, step 2, step 3 for the first time, for the second time, filtrate is placed in container and is uniformly mixed for the third time, precipitation, filters, and obtains filtrate, standby;
5) step 4 gained filtrate is concentrated by Chinese medicinal steaming hair device, be concentrated into 2/5ths of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, then by separation of ethanol, fluid extract for the first time; Add the ethanol of the content 95% of 0.8 times of weight to carry out precipitate with ethanol 48 hours fluid extract for the first time, then separating alcohol, fluid extract for the second time; Add the ethanol of the content 95% of 0.7 times of weight to carry out precipitate with ethanol 24 hours fluid extract for the second time, and then separation of ethanol, the crude drug extractum that obtains preparing, i.e. A component;
three, the preparation of B component:
1) Moschus, Venenum Bufonis and Squama Manis are added in ultrasonic extracting machine, inject 430kg purified water, open vacuum automatic switch, be decompressed to negative pressure 1MP, and be heated to 40 ℃, at 300MHz ultrasonic 50 minutes, medicinal liquid is leached, filtrate for the first time, standby;
2) ultrasonic extraction for the second time: in ultrasonic extracting machine, inject 342kg purified water, open vacuum automatic switch, be decompressed to negative pressure 0.8MP, and be heated to 45 ℃, at 400MHz ultrasonic 40 minutes, medicinal liquid is leached, filtrate for the second time, standby;
3) ultrasonic extraction for the third time: in ultrasonic extracting machine, inject 215kg purified water, open vacuum automatic switch, be decompressed to negative pressure 0.6MP, and be heated to 50 ℃, at 500MHz ultrasonic 1 hour, medicinal liquid is leached, filtrate for the third time, standby;
4) by standby to step 1, step 2, step 3 for the first time, for the second time, filtrate is placed in container stirring and evenly mixing for the third time;
5) step 4 gained medicinal liquid is concentrated by Chinese medicinal steaming hair device, be concentrated into 15% of filtrate volume, obtain concentrated solution, standby;
6) by step 5 gained concentrated solution, add the ethanol of the content 95% of 3 times of weight, to insert in alcohol precipitation tank, 80 ℃ of standing medicinal liquids filter after 80 hours again, get rid of medicinal residues;
7) decompression recycling ethanol, filters with filter paper after recovery ethanol again, then at 120 ℃, carries out high temperature sterilize filtrate 30 minutes, obtains B component;
four, A component and B component mixed and stirred, with sodium hydroxide, adjusting pH value to 6.0, then at 120 ℃, carrying out high temperature sterilize 30 minutes, the Chinese medicine composition that the bovine mastitis that obtains medical treatment is used.
effect embodiment
take the milch cow that suffers from mastitis as object, the therapeutic effect of the above-mentioned Chinese medicine composition that is used for the treatment of bovine mastitis is carried out to clinical trial.
, experiment material
(1) Chinese medicine composition of the treatment bovine mastitis that above-mentioned Preparation Example obtains;
(2) experimental animal:
from milk cattle cultivating community, new street, outskirts of a town township, Beian City, choose 120 milch cows that suffer from mastitis, the typical disease of these milch cows is: newborn district has obviously inflammation red, swollen, hot, pain to show, lethargy, inappetence, milk is rare clearly, jaundice with obvious floccule, and milk yield is starkly lower than healthy cow of the same age.
, experimental technique
above-mentioned 120 cow heads are divided into 4 groups at random, are respectively 30 of 30 of small dose group, 30 of middle dosage groups, heavy dose of groups, 30 of matched groups, respectively organize medication and method as following table:
medication group continuous use 10 days, every day, periodic monitor milch cow situation, disease and the situation of change of giving milk, judged curative effect according to the change of clinical symptoms and milk.Cure, effective and invalid criterion is as follows:
cure: newborn district is red, swollen, hot, pain disappears, milch cow spirit, appetite is normal, and milk perusal is normal, and milk yield returns to healthy cow level of the same age.
effective: newborn district is red, swollen, hot, pain obviously alleviates, and appetite is recovered to some extent, and milk floccule substantially disappears or obviously reduces, and milk yield is gone up.
invalid: newborn district is red, swollen, hot, pain nothing obviously alleviates, lethargy, inappetence, milk is clear rare or jaundice still, and flocculus is still more obvious.
, experimental result
small dose group is in medication after 10 days, and milch cow spirit, appetite are normal, and milk perusal is normal, and milk yield is recovered, and milch cow is all fully recovered.Middle dosage group is in medication after 8 days, and milch cow spirit, appetite are normal, and hollow billet is shinny, lots of natural fleshing, and milk perusal is normal, and milk yield is recovered, and milch cow is all fully recovered.Heavy dose of group is in medication after 6 days, and milch cow spirit, appetite are normal, and body condition is clearly better, lots of natural fleshing, and milk perusal is normal, and milk yield is recovered, and milch cow is all fully recovered.
10 days rear milk areas of milch cow of matched group are red, swollen, hot, pain is without significant change, lethargy, inappetence, milk is rare clearly, jaundice and flocculus still more obvious, compared to before 10 days without significant change.
, conclusion
the Chinese medicine composition for the treatment of bovine mastitis of the present invention has good therapeutic effect to bovine mastitis, can make the milch cow that suffers from mastitis recover Milk Production, and the sound development that improves milk production of cow and quality, promotion dairy is had to very positive effect.
above example of the present invention is had been described in detail, but described content is only preferred embodiments of the present invention, can not be considered to for limiting practical range of the present invention.All equalization variations of doing according to the present patent application scope and improvement etc., all should belong to patent covering scope of the present invention.
Claims (2)
1. a Chinese medicine composition for the treatment of bovine mastitis, is characterized in that: said composition is comprised of A component and B component, and wherein A component is prepared from by the crude drug of following weight portion:
Radix Bupleuri: 10 Herba Violaes: 50 Herba Taraxacis: 60
Flos Chrysanthemi Indici: 50 Fructus Forsythiaes: 30 Herba Andrographis: 50;
B component is prepared from by the crude drug of following weight portion:
Moschus: 0.8 Venenum Bufonis: 2 Squama Maniss: 40.
2. the preparation method of the Chinese medicine composition for the treatment of bovine mastitis claimed in claim 1, comprises the following steps:
One, Radix Bupleuri, Herba Violae, Herba Taraxaci, Flos Chrysanthemi Indici, Fructus Forsythiae, Herba Andrographis, Squama Manis, Moschus and Venenum Bufonis are cleaned, clean, dry, pulverize into coarse powder, weigh by weight, standby;
Two, the preparation of A component:
1) Radix Bupleuri, Herba Violae, Herba Taraxaci, Flos Chrysanthemi Indici, Fructus Forsythiae and Herba Andrographis are added in extraction pot, inject the purified water of 8-12 times of weight of above-mentioned 6 taste medicines, be heated to boil, decoct 3 hours, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) herb liquid extracts for the second time: in extraction pot, inject the purified water of 6-10 times of weight of above-mentioned 6 taste medicines, be heated to boil, decoct 2 hours, medicinal liquid is leached, obtain filtrate for the second time, and standby;
3) herb liquid extracts for the third time: in extraction pot, inject the purified water of 4-6 times of weight of above-mentioned 6 taste medicines, be heated to boil, decoct 1 hour, medicinal liquid is leached, obtain filtrate for the third time, and standby;
4) by standby to step 1, step 2, step 3 for the first time, for the second time, filtrate is placed in container and is uniformly mixed for the third time, precipitation, filters, and obtains filtrate, standby;
5) step 4 gained filtrate is concentrated by Chinese medicinal steaming hair device, be concentrated into 2/5ths of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 1 times of weight, carries out precipitate with ethanol 72 hours, then by separation of ethanol, fluid extract for the first time; Add the ethanol of the content 95% of 0.8 times of weight to carry out precipitate with ethanol 48 hours fluid extract for the first time, then separating alcohol, fluid extract for the second time; Add the ethanol of the content 95% of 0.7 times of weight to carry out precipitate with ethanol 24 hours fluid extract for the second time, and then separation of ethanol, the crude drug extractum that obtains preparing, i.e. A component;
Three, the preparation of B component:
1) Moschus, Venenum Bufonis and Squama Manis are added in ultrasonic extracting machine, inject above-mentioned 3 taste medicine weight 8-12 purified water doubly, open vacuum automatic switch, be decompressed to negative pressure 0.5-1.5MP, and be heated to 40 ℃-50 ℃, at the ultrasonic 40-50 minute of 200MHz-300MHz, medicinal liquid is leached, obtain filtrate for the first time, standby;
2) ultrasonic extraction for the second time: in ultrasonic extracting machine, inject above-mentioned 3 taste medicine weight 6-16 purified water doubly, open vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to 40 ℃-50 ℃, at the ultrasonic 30-40 minute of 300MHz-500MHz, medicinal liquid is leached, obtain filtrate for the second time, standby;
3) ultrasonic extraction for the third time: in ultrasonic extracting machine, inject above-mentioned 3 taste medicine weight 4-6 purified water doubly, open vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to 40 ℃-50 ℃, at 400MHz-500MHz ultrasonic 1 hour, medicinal liquid is leached, obtain filtrate for the third time, standby;
4) by standby to step 1, step 2, step 3 for the first time, for the second time, filtrate is placed in container stirring and evenly mixing for the third time;
5) step 4 gained medicinal liquid is concentrated by Chinese medicinal steaming hair device, be concentrated into 15% of filtrate volume, obtain concentrated solution, standby;
6) step 5 gained concentrated solution is added to the ethanol of the content 95% of 3 times of weight, insert in alcohol precipitation tank, 80 ℃ of standing medicinal liquids filter after 80 hours again, get rid of medicinal residues;
7) decompression recycling ethanol, filters with filter paper after recovery ethanol again, then at 120 ℃, carries out high temperature sterilize filtrate 30 minutes, obtains B component;
Four, A component and B component mixed and stirred, with sodium hydroxide, adjusting pH value to 4.6～6.0, then at 120 ℃, carrying out high temperature sterilize 30 minutes, must treat the Chinese medicine composition that bovine mastitis is used.
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Application publication date: 20140430 |