CN104208294A - Traditional Chinese medicine composition for treating piglet yellow-white dysentery and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating piglet yellow-white dysentery and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating piglet yellow-white dysentery and a preparation method thereof, and belongs to the technical field of veterinary traditional Chinese medicine. The traditional Chinese medicine composition is mainly composed of the following traditional Chinese herbals in parts by weight: 100 parts of poplar flower, 9 to 15 parts of coptis, 20 to 40 parts of Chinese pulsatilla root, 15 to 30 parts of purslane, 15 to 30 parts of phellodendron, 15 to 30 parts of ash bark, 15 to 30 parts of andrographis paniculata, and 15 to 30 parts of folium isatidis. The raw materials mentioned above are compounded according to the principle of "monarch, minister, assistant and guide" in the traditional Chinese medicine theory. The Chinese pulsatilla root has a bitter cold property, is capable of entering the blood, is taken as the monarch drug, and has the functions of clearing heat, removing toxicity, cooling the blood, and stopping the dysentery. The coptis has a bitter cold property, has the functions of purging fire, removing toxicity, drying dampness, and protecting intestines, and is an effective drug for treating dysentery; the phellodendron has the function of clearing dampness and heat in lower jiao, and the coptis and phellodendron are taken as the minister drugs to assist the monarch drug to exert the functions of clearing heat and removing toxicity, especially the functions of drying dampness and stopping dysentery. Ash bark, andrographis paniculata, poplar flower, purslane, folium isatidis have a bitter taste and a cold property, have the functions of clearing heat, removing toxicity, inducing astringency, and stopping dysentery, and are taken as the assistant and guide drugs. The drugs mentioned above cooperate with each other to generate the functions of clearing heat, removing toxicity, cooling the blood, and stopping dysentery, and the traditional Chinese medicine composition is mainly used to treat piglet yellow-white dysentery.
Description
Technical field
The present invention is specifically related to a kind of Chinese medicine composition being used for the treatment of yellow and white dysentery of piglet, and the preparation method of this Chinese medicine composition, belongs to technical field of Chinese medicine for animals.
Background technology
Yellow and white dysentery of piglet is the infectious intestinal disease of the pig caused by Escherichia coli.Suckling pig within yellow scours is mainly in 1 week age, 1 ~ 3 age in days is the most common, and piglets morbidities more than 7 ages in days is few.Yellow scours discharges yellow or lark water sample loose stool to suffer from diarrhoea, and morbidity is anxious, and rapid dehydration, weak, death is feature, and sickness rate is usually more than 90%, and mortality rate can up to 100%.Sickness rate reduces gradually with the increase of age in days.Hakuri generally betides 7 ~ 30 age in days piglets, cause diarrhoea, and the piglet about 1 ~ 2 age in days easily causes enteritis and septicemia.Smell as of rotten fish feces for feature with dysentery, discharge milky or canescence thickness clinically, and cuing open inspection is feature with enteritis.Hakuri easily causes piglet death or retarded growth.Sickness rate is generally 10 ~ 30%, and mortality rate is 10%.For a long time, yellow and white dysentery of piglet has carried out economic loss seriously to industrial belt of raising pigs.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition being used for the treatment of yellow and white dysentery of piglet.
Meanwhile, the present invention also provides a kind of preparation method being used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet.
In order to realize above object, the technical solution adopted in the present invention is:
Be used for the treatment of a Chinese medicine composition for yellow and white dysentery of piglet, the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 9 ~ 15 parts, the Radix Pulsatillae 20 ~ 40 parts, Herba Portulacae 15 ~ 30 parts, Cortex Phellodendri 15 ~ 30 parts, Cortex Fraxini 15 ~ 30 parts, Herba Andrographis 15 ~ 30 parts, Folium Isatidis 15 ~ 30 parts.
Preferably, be used for the treatment of a Chinese medicine composition for yellow and white dysentery of piglet, the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 9 parts, the Radix Pulsatillae 24 parts, Herba Portulacae 21 parts, Cortex Phellodendri 18 parts, Cortex Fraxini 18 parts, Herba Andrographis 30 parts, Folium Isatidis 30 parts.
Each crude drug effect is summarized as follows:
Flower of poplar: be Salicaceae poplar Cortex Populi Tomentosae, eugene poplar or the staminate inflorescence belonging to several plants together; Nature and flavor are bitter, cold; Energy heat-clearing and toxic substances removing, removing dampness dysentery relieving; Cure mainly bacillary dysentery, enteritis.
Rhizoma Coptidis: be the rhizome of Rhizoma Imperatae section coptis plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis teeta; Containing alkaloids as various active compositions such as berberine, coptisine, epiberberine, obacunone; Rhizoma Coptidis nature and flavor are bitter, cold, GUIXIN, liver, stomach, large intestine channel; Energy clearing away heat-fire, dampness, removing toxic substances; Cure mainly the high heat that calentura heresy enters heart channel, irritated, the damp and hot feeling of stuffiness in chest, has loose bowels, dysentery, the vexed insomnia of hyperactivity of heart-fire, gastropyretic vomiting, rapid digestion of food and polyorexia, liver-fire conjunctival congestion and swelling pain, and pathopyretic ulcer, furunculosis septicemia, gingival swelling and pain, aphtha of the mouth and tongue, hemorrhoidal bleeding, eczema, scalds; Modern pharmacology proves that Rhizoma Coptidis has an impact to blood circulation, nervous system, also has the effects such as antimicrobial, protozoacide, antiulcer, antiviral, antiinflammatory, antitumor, blood sugar lowering, anticoagulant.
The Radix Pulsatillae: be the root of the Ranunculaceae Pulsatilla plant Radix Pulsatillae; Containing triterpenoid as the plurality of active ingredients such as Anemonin, betulic acid, 3-oxo fat acid, Pulsatilla saponin A, B, C, D; Nature and flavor are bitter, cold, return stomach, large intestine channel; Energy heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites; Cure mainly dysentery, epistaxis, internal hemorrhoid with bleeding, cold and heat pyrexial malaria, scrofula, eczema carbuncle skin ulcer, eyes swelling pain etc.; Modern pharmacology proves that the Radix Pulsatillae has resisting pathogenic microbes, anti-ameba, other pathogen anti-, antitumor, antiinflammatory and strengthens the effects such as immunologic function.
Herba Portulacae: be the herb of Portulacaceae portulaca Herba Portulacae; Containing a large amount of norepinephrine and volume potassium salt (comprising potassium nitrate, potassium chloride, potassium sulfate and other potassium salt), also containing DOPA, dopamine, betanidin, isobetanidin, betanin etc., amino acids as glutamic acid, aspartic acid, alanine, polysaccharide and other multiple active components; Nature and flavor are sour, cold, return large intestine, Liver Channel; Energy heat clearing away, removing toxic substances, removing heat from blood, detumescence; Cure mainly pyretic toxicity dysentery, pyretic stranguria stranguria with blood, erysipelas scrofula etc.; Modern pharmacology proves that Herba Portulacae has the effects such as antibacterial, blood fat reducing, atherosclerosis.
Cortex Phellodendri: be the bark of Rutaceae Phellodendron plant wampee or Cortex Phellodendri; Containing alkaloids as berberine, phellodendrine, magnoflorine, jateorhizine etc., also containing plurality of active ingredients such as limonin, obacunone, campesterol, stigmasterol; Nature and flavor are bitter, cold, return kidney, bladder, large intestine channel; Energy heat clearing and damp drying, eliminating fire and detoxication; Cure mainly hygropyretic dysentery, have loose bowels, jaundice, hectic fever due to YIN-deficiency consumptive fever, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore etc.; Modern pharmacology proves that Cortex Phellodendri has resisting pathogenic microbes, antipyretic and effect such as anti-inflammatory, antiplatelet aggregation, has facilitation to cardiovascular system, digestive system and maincenter kidney channel system.
Cortex Fraxini: be the bark of Oleaceae Fraxinus plant great Ye Ash, sharp leaf Ash, Chinese ash and Fraxinus fallax Lingelsh．; Containing aesculin, aesculetin, also contain Coumarins as various active compositions such as aesculetin, fraxetin and alkaloids; Nature and flavor are bitter, puckery, cold, return liver, gallbladder, large intestine channel; Energy heat clearing and damp drying, liver heat removing and eyesight improving; Cure mainly damp-heat dysentery, conjunctival congestion and swelling pain, lung-heat asthma and cough etc.; Modern pharmacology proves that Cortex Fraxini has the effects such as antibacterial, eliminating phlegm and stopping cough.
Herba Andrographis: be the herb of Acanthaceae Herba Andrographis platymiscium Herba Andrographis; Leaf contains Diterpenes as andrographolide etc., flavonoid is as oroxylin A, wogonin, also contain Polyphenols as caffeic acid, chlorogenic acid etc., root contains flavonoid as andrographin, andrographin glycosides A, B, C, D, E and F, also containing various active compositions such as α-Sitosterols; Nature and flavor are bitter, contain, GUIXIN, lung, large intestine, urinary bladder channel; Energy heat-clearing and toxic substances removing, pathogenic fire purging, dampness; Cure mainly anemopyretic cold, epidemic febrile disease heating, cough due to lung-heat, pertussis, lung abscess, laryngopharynx swelling and pain, toothache due to stomach-fire, acute bacillary dysentery, jaundice due to damp-heat, skin infection carbuncle etc.; Modern pharmacology proves that Herba Andrographis has antipyretic, antiinflammatory, anticancer, D-dimer, antithrombotic, hepatic cholagogic, blood pressure lowering, antioxidant protection Endothelial Cell Function etc.
Folium Isatidis: be the leaf of Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort.; Containing indigo, the plurality of active ingredients such as Isatis indigotica Fort. glycosides, indirubin, rosasterol; Nature and flavor are bitter, cold; GUIXIN, stomach, liver, lung meridian; Energy heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly the high hot excessive thirst of epidemic febrile disease, coma, macule, spits blood, epistaxis, jaundice, dysentery, erysipelas, sore throat, aphtha, mumps etc.; Modern pharmacology proves that Folium Isatidis has the effects such as resisting pathogenic microbes, antiendotoxin, antioxidation.
Be used for the treatment of a Chinese medicine composition for yellow and white dysentery of piglet, conventional method can be adopted to be prepared into the common veterinary dosage form such as granule, powder, solution, injection.The present invention only provides a kind of preparation method of solution, comprises the following steps:
(1) accurately get each taste crude drug according to parts by weight, flower of poplar, Rhizoma Coptidis, the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Cortex Fraxini, Folium Isatidis are decocted with water 2 times, merge 2 decocting liquids, adding ethanol to alcohol content is 50 ~ 80%, and it is for subsequent use that recovery ethanol obtains extractum A;
(2) get Herba Andrographis ethanol extraction 2 times, merge 2 filtrates, it is for subsequent use that recovery ethanol obtains extractum B;
(3) merge extractum A and extractum B, add tween 80, regulate solution ph to be 5 ~ 7, filter and get final product.
Decoct in described step (1) and add 8 ~ 10 times of water gagings, decoct 1 ~ 2 hour.
In described step (2), ethanol extraction adds 6 ~ 8 times amount ethanol.
In described step (3), the addition of tween 80 is 1 ~ 5 weight portion.
Mend to 100 weight portions by purified water after adjust ph in described step (3).
Usage and consumption: horse, cattle 50 ~ 100ml, sheep, pig 10 ~ 20ml, rabbit, fowl 1 ~ 2ml.
Beneficial effect of the present invention:
Theoretical and the clinical treatment by Chinese herbs practice according to traditional Chinese veterinary medicine, treatment yellow and white dysentery of piglet heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, heat should move back poison and separates, then dysentery only then weighs and certainly removes.
The present invention adopts flower of poplar, Rhizoma Coptidis, the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Cortex Fraxini, Herba Andrographis, Folium Isatidis totally 8 taste pure natural Chinese herbal medicine, according to monarch principle composition of prescription.Bitter cold in side and the Radix Pulsatillae entering blood system is monarch drug, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Rhizoma Coptidis bitter cold, the thick intestinal of eliminating fire and detoxication, dampness, for controlling dysentery key medicine; The clear damp-heat in lower-JIAO of Cortex Phellodendri, two medicines are principal drug assistance heat-clearing and toxic substances removing altogether, and especially dampness can control dysentery, be ministerial drug altogether.Cortex Fraxini, Herba Andrographis, flower of poplar, Herba Portulacae, Folium Isatidis is pained and tremble with fear, heat-clearing and toxic substances removing and double with astringent therapy dysentery relieving, is adjuvant.All medicines share, and play the merit of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery altogether, are mainly used in treating yellow and white dysentery of piglet.
The present invention adopts pure natural Chinese herbal medicine, and crude drug is easy to get, cheap and safety, noresidue, without any side effects to poultry body.Above-mentioned Chinese medicine composition is prepared into solution by the present invention, and method is simple, be easy to operation, is suitable for large-scale production and application.
Detailed description of the invention
Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.
Embodiment 1
Be used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 15 parts, the Radix Pulsatillae 20 parts, Herba Portulacae 30 parts, Cortex Phellodendri 30 parts, Cortex Fraxini 15 parts, Herba Andrographis 15 parts, Folium Isatidis 15 parts.
Be used for the treatment of the preparation method of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, comprise the following steps:
(1) accurately get flower of poplar, Rhizoma Coptidis, the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Cortex Fraxini, Folium Isatidis according to parts by weight, add 8 times of water gagings, decoct 2 times, each decoction 1.5 hours, merge 2 decocting liquids, adding ethanol to alcohol content is 60%, and it is for subsequent use that recovery ethanol obtains extractum A;
(2) accurately get Herba Andrographis according to parts by weight, add 6 times amount ethanol, alcohol extraction 2 times, merge 2 filtrates, it is for subsequent use that recovery ethanol obtains extractum B;
(3) merge extractum A and extractum B, with weight parts, add 1 part of tween 80, regulate solution ph to be 7, supplementary purified water to 100 part, then use 0.45 μm of membrane filtration, fill and get final product.
Usage and consumption: horse, cattle 50 ~ 100ml, sheep, pig 10 ~ 20ml, rabbit, fowl 1 ~ 2ml.
Embodiment 2
Be used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 9 parts, the Radix Pulsatillae 24 parts, Herba Portulacae 21 parts, Cortex Phellodendri 18 parts, Cortex Fraxini 18 parts, Herba Andrographis 30 parts, Folium Isatidis 30 parts.
Be used for the treatment of the preparation method of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, comprise the following steps:
(1) accurately get flower of poplar, Rhizoma Coptidis, the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Cortex Fraxini, Folium Isatidis according to parts by weight, add 8 times of water gagings, decoct 2 times, each decoction 1.5 hours, merge 2 decocting liquids, adding ethanol to alcohol content is 65%, and it is for subsequent use that recovery ethanol obtains extractum A;
(2) accurately get Herba Andrographis according to parts by weight, add 8 times amount ethanol, alcohol extraction 2 times, merge 2 filtrates, it is for subsequent use that recovery ethanol obtains extractum B;
(3) merge extractum A and extractum B, with weight parts, add 2 parts of tween 80s, regulate solution ph to be 7, supplementary purified water to 100 part, then use 0.45 μm of membrane filtration, fill and get final product.
Usage and consumption: horse, cattle 50 ~ 100ml, sheep, pig 10 ~ 20ml, rabbit, fowl 1 ~ 2ml.
Embodiment 3
Be used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 12 parts, the Radix Pulsatillae 30 parts, Herba Portulacae 18 parts, Cortex Phellodendri 21 parts, Cortex Fraxini 21 parts, Herba Andrographis 24 parts, Folium Isatidis 24 parts.
Be used for the treatment of the preparation method of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, comprise the following steps:
(1) accurately get flower of poplar, Rhizoma Coptidis, the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Cortex Fraxini, Folium Isatidis according to parts by weight, add 10 times of water gagings, decoct 2 times, each decoction 1.5 hours, merge 2 decocting liquids, adding ethanol to alcohol content is 65%, and it is for subsequent use that recovery ethanol obtains extractum A;
(2) accurately get Herba Andrographis according to parts by weight, add 8 times amount ethanol, alcohol extraction 2 times, merge 2 filtrates, it is for subsequent use that recovery ethanol obtains extractum B;
(3) merge extractum A and extractum B, with weight parts, add 5 parts of tween 80s, regulate solution ph to be 7, supplementary purified water to 100 part, then use 0.45 μm of membrane filtration, fill and get final product.
Usage and consumption: horse, cattle 50 ~ 100ml, sheep, pig 10 ~ 20ml, rabbit, fowl 1 ~ 2ml.
Embodiment 4
Be used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 12 parts, the Radix Pulsatillae 25 parts, Herba Portulacae 15 parts, Cortex Phellodendri 15 parts, Cortex Fraxini 30 parts, Herba Andrographis 24 parts, Folium Isatidis 24 parts.
Be used for the treatment of the preparation method of the Chinese medicine composition of yellow and white dysentery of piglet in the present embodiment, comprise the following steps:
(1) accurately get flower of poplar, Rhizoma Coptidis, the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Cortex Fraxini, Folium Isatidis according to parts by weight, add 8 times of water gagings, decoct 2 times, each decoction 1.5 hours, merge 2 decocting liquids, adding ethanol to alcohol content is 65%, and it is for subsequent use that recovery ethanol obtains extractum A;
(2) accurately get Herba Andrographis according to parts by weight, add 8 times amount ethanol, alcohol extraction 2 times, merge 2 filtrates, it is for subsequent use that recovery ethanol obtains extractum B;
(3) merge extractum A and extractum B, with weight parts, add 3 parts of tween 80s, adjustment solution ph is 7, then uses 0.45 μm of membrane filtration, fill and get final product.
Usage and consumption: horse, cattle 50 ~ 100ml, sheep, pig 10 ~ 20ml, rabbit, fowl 1 ~ 2ml.
Test example
1, trial drug: the solution that test group adopts embodiment 1 ~ 3 to prepare, matched group adopts commercially available enrofloxacin soluble powder, is provided by Zhengzhou Houyi Pharmaceutical Co., Ltd., and product batch number is: 20110110.
2, Antigen isolation and identification: gather feces from the frank sick pig rectum of Hakuri with disinfecting silk or cotton swab, be inoculated on Mai Kangkai flat board, cultivate 24 ~ 48h, the brick-red bacterium colony that picking is smooth for 37 DEG C, after several separation and purification, be inoculated on ordinary broth culture fluid and nutrient agar panel.Picking pure culture smear, microscopy, and carry out biochemical test and mice Virulence detection.
3, the external mattress that presses down is tested
(1) extracorporeal bacteria inhibitor test of Chinese medicine: punch on the agar culture medium being coated with pathogen, and it is a little to add the sterilizing agar dissolved at the bottom of hole, to seal at the bottom of hole, solution prepared by embodiment 1 ~ 3 is added respectively in hole, be advisable to fill it up with not overflow, put after cultivating 24h in 37 DEG C of incubators, measure antibacterial circle diameter.
(2) drug sensitive test of antimicrobial drug: select enrofloxacin, ciprofloxacin, ceftazidime, rifampicin, cephazolin, furazolidone, ampicillin, ceftriaxone sodium, spectinomycin, norfloxacin to carry out drug sensitive test.
Criterion: antibacterial circle diameter≤10mm is drug resistance; L0 ~ 15mm is medium sensitivity; >=15mm, for extremely sensitive.
4, test method
Experimental animal: choose 10 ~ 30 age in days generation Hakuri and the obvious piglet of clinical symptoms 400, according to the principle that disease time, age in days, severity extent, body condition are relatively consistent, adopt the method for grouping in nest, the piglet suffering from Hakuri is divided into 4 groups at random, often organize 100.Test group 1 ~ 3 gavages solution prepared by embodiment 1 ~ 3, and every each 10ml, every day 2 times, is used in conjunction 3 days; Matched group adopts commercially available pig specific drug enrofloxacin soluble powder to treat, and every pig 1.2g, is dissolved in 5ml warm water and gavages, and every day 2 times, is used in conjunction 3 days.
Curative effect determinate standard:
Cure: after testing 1 course for the treatment of of disease pig medication, feces, spirit, appetite recover normal;
Effective: after testing 1 course for the treatment of of disease pig medication, pellet morphology takes a turn for the better, and number of times of having loose bowels reduces, and appetite takes a turn for the better;
Invalid: after testing 1 course for the treatment of of disease pig medication, symptom is not improved, even to increase the weight of or dead.
5, date processing: the significance test carrying out data with statistical method, cure rate, total effective rate X 2 test.
6, result of the test
(1) Antigen isolation and identification
Through test for identification, the antibacterial be separated to from morbidity piglet feces is pathogenic colon bacillus.
(2) extracorporeal bacteria inhibitor test of Chinese medicine
The diameter that embodiment 1 ~ 3 prepares the inhibition zone of solution is respectively 12.0mm, 12.7mm and 11.5mm, and establishing criteria is judged to be medium sensitivity.Result of the test shows that By Chinese Medicines agent of the present invention has certain inhibitory action to colon bacillus.
(3) drug sensitive test of antimicrobial drug
As can be seen from Table 1, enrofloxacin, ceftriaxone sodium, ring receives the third husky star, cephazolin is Gao Min; Ceftazidime, ampicillin, spectinomycin, norfloxacin are quick in being; Rifampicin is drug resistance.Therefore select enrofloxacin medicine as a control group.
Table 1 antibacterials are to the fungistatic effect being separated Enteropathogenic Escherichia coli
(4) Chinese medicine is to the therapeutic effect of yellow and white dysentery of piglet
As can be seen from Table 2, the total effective rate of test group reaches more than 95%.Statistical analysis shows, the cure rate of test group is significantly higher than matched group (P < 0.01), without significant difference (P > 0.05) between total effective rate.Also without significant difference (P > 0.05) between the total effective rate of test group 1 ~ 3.
The each processed group of table 2 is to the therapeutic effect of yellow and white dysentery of piglet
Discuss:
Piglet pujos blancos is primarily of caused by pathogenic colon bacillus, and the source of infection normally carries disease germs sow.Pathogenic colon bacillus, after sow excretes, intersperses among colony house, pollutes the nipple of sow and skin, and piglet is sucked the breast or when licking sow skin, The book of Changes oral cavity infection.The In Vitro Bacteriostasis result that embodiment 1 ~ 3 prepares solution shows, Chinese medicine of the present invention has certain inhibitory action to pathogenic colon bacillus.From fungistatic effect, the cure rate of test group 1 ~ 3 is apparently higher than enrofloxacin (P < 0.01), and enrofloxacin easily produces resistant strains.Result of the test also shows, Chinese herbal and crude drugs preparations, except having antibacterial action, also by other approach, such as resists the enterotoxin that colon bacillus produces, with the mucoprotein formation protecting film in intestinal mucosa surface, and the physiological function etc. of adjustment biological organs.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for yellow and white dysentery of piglet, it is characterized in that: the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 9 ~ 15 parts, the Radix Pulsatillae 20 ~ 40 parts, Herba Portulacae 15 ~ 30 parts, Cortex Phellodendri 15 ~ 30 parts, Cortex Fraxini 15 ~ 30 parts, Herba Andrographis 15 ~ 30 parts, Folium Isatidis 15 ~ 30 parts.
2. the Chinese medicine composition being used for the treatment of yellow and white dysentery of piglet according to claim 1, is characterized in that: the crude drug primarily of following parts by weight forms: flower of poplar 100 parts, Rhizoma Coptidis 9 parts, the Radix Pulsatillae 24 parts, Herba Portulacae 21 parts, Cortex Phellodendri 18 parts, Cortex Fraxini 18 parts, Herba Andrographis 30 parts, Folium Isatidis 30 parts.
3. be used for the treatment of a preparation method for the Chinese medicine composition of yellow and white dysentery of piglet as claimed in claim 1 or 2, it is characterized in that: comprise the following steps:
(1) accurately get each taste crude drug according to parts by weight, flower of poplar, Rhizoma Coptidis, the Radix Pulsatillae, Herba Portulacae, Cortex Phellodendri, Cortex Fraxini, Folium Isatidis are decocted with water 2 times, merge 2 decocting liquids, adding ethanol to alcohol content is 50 ~ 80%, and it is for subsequent use that recovery ethanol obtains extractum A;
(2) get Herba Andrographis ethanol extraction 2 times, merge 2 filtrates, it is for subsequent use that recovery ethanol obtains extractum B;
(3) merge extractum A and extractum B, add tween 80, regulate solution ph to be 5 ~ 7, filter and get final product.
4. the preparation method being used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet according to claim 3, is characterized in that: decoct in described step (1) and add 8 ~ 10 times of water gagings, decoct 1 ~ 2 hour.
5. the preparation method being used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet according to claim 3, is characterized in that: in described step (2), ethanol extraction adds 6 ~ 8 times amount ethanol.
6. the preparation method being used for the treatment of the Chinese medicine composition of yellow and white dysentery of piglet according to claim 3, is characterized in that: in described step (3), the addition of tween 80 is 1 ~ 5 weight portion.
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| CN105055614A (en) * | 2015-08-25 | 2015-11-18 | 河南省睿兰特生物制药有限公司 | Preparation process of Chinese herbal medicine concentrated medicine for treating livestock and poultry intestinal diseases |
| CN105106394A (en) * | 2015-09-17 | 2015-12-02 | 福建傲农生物科技集团股份有限公司 | Chinese herb preparation for preventing and treating animal digestive canal infection and preparing method and application thereof |
| CN105106387A (en) * | 2015-09-25 | 2015-12-02 | 全椒县大地种植专业合作社 | Medicine for preventing and treating white scour of piglets |
| CN115715783A (en) * | 2022-12-27 | 2023-02-28 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating swine white diarrhea and preparation method thereof |
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| CN115715783A (en) * | 2022-12-27 | 2023-02-28 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating swine white diarrhea and preparation method thereof |
| CN115715783B (en) * | 2022-12-27 | 2023-07-25 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating white diarrhea of pigs and preparation method thereof |
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