CN109010487A - A kind of oral solution for alleviating children's upper respiratory tract infection symptom - Google Patents

A kind of oral solution for alleviating children's upper respiratory tract infection symptom Download PDF

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CN109010487A
CN109010487A CN201811219579.5A CN201811219579A CN109010487A CN 109010487 A CN109010487 A CN 109010487A CN 201811219579 A CN201811219579 A CN 201811219579A CN 109010487 A CN109010487 A CN 109010487A
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supercritical
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oral solution
honeysuckle
elscholtiza
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李向东
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GUIYANG GAOXIN RUIDE TECHNOLOGY DEVELOPMENT Co Ltd
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    • A61K2236/30—Extraction of the material
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Abstract

A kind of oral solution for alleviating children's upper respiratory tract infection symptom, belongs to health food.The oral solution passes through supercritical CO by medicinal material cordate houttuynia, honeysuckle, elscholtiza2The extract being obtained by extraction adds cosolvent and pure water, through made of ultrafiltration.The cosolvent is Tween-80.Preparation method is to clean respectively in advance, hot-air seasoning, disinfection by ultraviolet light, the fresh cordate houttuynia of grind into powder, honeysuckle, and elscholtiza is extracted with supercritical extract instrument respectively；Then flavour amino acid, honeysuckle and elscholtiza supercritical CO are taken2Each 1 part of extract, mixing；Tween-80 hydrotropy is added, water for injection or pure water is added to carry out ultrafiltration membrance filter, filtrate it is filling to get.This oral solution is used as health food, and cooperation traditional Chinese and western medicine drug has clearing heat-fire, diuresis clearing damp, eliminating inflammation and expelling toxin function for sense on children, also effective for adult patient.Oral solution of the invention is easy to infant taking, can mitigate the symptom and pain of patient.Suitable for feeling on adjuvant treatment children.

Description

A kind of oral solution for alleviating children's upper respiratory tract infection symptom
Technical field
The present invention relates to health foods, in particular to the oral solution for alleviating children's upper respiratory tract infection symptom.
Background technique
The infection of the upper respiratory tractIt is the common disease of infant, that is, the flu often said, refers to nose, the pharynx of top respiratory tract With the respiratory inflammation of throat, clinical diagnosis "Acute tonsillitis"、"Acpuei pharyngitis"、"Acute nasopharyngitisIt " belongs to Sense.It can all fall ill throughout the year, but more when winter-spring season alternating, infant is most common, often has for several times every year, Symptoms are light Severe is different.Mild shows as low-heat, runny nose, has a stuffy nose, tussiculas, sneezing, diarrhea or slight vomiting etc., and schneiderian membrance is congested Oedema, secretion increase, pharyngeal slightly red, neck orSubmandibular lymph nodesCan silght enlargement, the state of mind is good, and natural history is 3 ~7 days or so；Severe one fever, often at 39 DEG C or more, Symptoms are weaker spirit, headache, paroxysmal cough, pharyngalgia, vomiting, weary Power, chilly, loss of appetite etc. have apparent congestion of throat,Tonsillotome is red and swollen, submandibular lymph nodes enlargement tenderness.Inflammation can also wave And middle ear, nasal sinus and tracheae, causeTympanitis, nasosinusitis and tracheitis.It sometimes can also be with abdominal pain.
The infection of the upper respiratory tractTraditional Chinese and western medicine cures with medicine, but under normal conditions, drug effect is slower, and children's majority is reluctant Meaning medication, is more reluctant to have an injection, and symptom is difficult to control.
Have the Chinese patent of the food application for treating flu, such as No. 2009102330147 " a kind of heat-clearing in recent years Removing toxic substances, the anti-novel food capsule to cure cold and production method ", a kind of No. 2011100223006 " foods of prophylactic treatment anemofrigid cold Product formula ", No. 2014800622366 " for treat or prevent influenza infection containing 2- fucosylation oligosaccharide Infant formula ", No. 2016105823432 " a kind of health food for easy catching a cold constitution " etc..These patent applications How unknown part effect is.But people are still exploring and are studying update, more effective health food, can be to treatment Generation effect is felt on children, is the health service of infant.
Summary of the invention
The present invention is intended to provide a kind of oral solution for alleviating children's upper respiratory tract infection symptom, promotes the drug felt in treatment Curative effect, convenient for harm of the susceptible disease to infantile health in infant taking, elimination.
It is yet another object of the invention to provide the preparation methods of above-mentioned oral solution, can produce in batches.
It is by following 3 kinds of medicinal materials that the oral solution of alleviation children's upper respiratory tract infection symptom of the invention, which is controlled:
Cordate houttuynia, honeysuckle, elscholtiza
Pass through supercritical CO2The extract being obtained by extraction adds cosolvent and pure water, through made of ultrafiltration:
The cosolvent is Tween-80.
In above-mentioned formula, cordate houttuynia be saururaceae plant houttuynia cordata (Houttuynia cordata) whole herb with root, taste It is pungent, cold in nature, there is clearing heat and detoxicating, inducing diuresis to remove edema effect (see the new medical college's volume " dictionary of medicinal plant " page 1439 in Jiangsu)；Honeysuckle is Caprifoliaceae plant honeysuckle (Lonicera japonica) bud, it is sweet in flavor, it is cold in nature, can be clearing heat and detoxicating (see " dictionary of medicinal plant " Page 1403)；Elscholtiza Labiatae Elsholtzia species elsholtzia splendens (Elsholtzia splendens) wounded in the battle herb, acrid flavour, property Tepor, can sweating, row water dissipate it is wet, (see " dictionary of medicinal plant " page 1680) in warm stomach tune.
Relevant medical literature report:
(1) the pharmacological action of cordate houttuynia: 1. antibacterial action: raising a kind of yellow oil in cordate houttuynia, (outstanding to various microorganisms It is saccharomycete and mould) there is inhibiting effect, to the streptococcus of hemolytic, staphylococcus aureus, Bacillus influenzae, catarrh ball Bacterium, pneumococcus have apparent inhibiting effect.Also there is effect to Escherichia coli, shigella dysenteriae, typhoid bacillus.2. virus function: With the primary adhesion tissue cultures of human embryo kidney (HEK), cordate houttuynia decoction (1: 10) has suppression for section 68-1 plants to influenza Asia A type capital Production is used, and can delay the growth of orphan virus ECHO11.Zhu Yu is with report: being extracted to obtain several fixed oil portions with ethyl alcohol Part.Wherein III influenza virus infected of decanoy acetaldehyde has preventive protection effect, acts on EMC and HSV II unobvious, conjunction Also there is stronger antivirus action at the derivative of decanoy acetaldehyde.Houttuynia extract (4g crude drug/ml) is to resurgent Influenza Virus sense The mouse of dye has obvious preventive effect.And to encephalomyocarditis virus and herpesvirusⅡtype infection without obvious protective function. And cordate houttuynia resisiting influenza virus ingredient is proved not in volatile oil part, and in non-volatile matter.Experiment in vitro proves cordate houttuynia water Extract can inhibit 1 type and herpes simplex types 2 virus infection, and specific mechanism is that transcription factor needed for suppressing virus replication is living Property.3. diuresis houttuynia extract perfusion toad kidney or frog web can make telangiectasis, increase blood flow and urine Liquid secretion, to have the function of diuresis.It is acted on may be caused by organic matter, and potassium only acts the adjection for increasing diuresis, directly When connecing effect, Leptospira activity decrease-death-cracking can be made, can also postpone the cavy of artificial challenge Leptospira Period of disease.4. the effect to immune system: human peripheral leucocytes phagocytosis gold can be obviously promoted in vitro in cordate houttuynia decoction The ability of staphylococcus aureus, sodium houttuyfonate can improve the phagocytic function of chronic bronchitis patients leucocyte, improve rabbit And patients serum's properdin is horizontal.5. antitumor action: neohouttuynin may be with raising to the inhibitory effect of ehrlich ascites cancer The related experiment of cAMP level in cancer cell shows: the new cordate houttuynia in different time to mouse peritoneal injection various dose Element, cancer cell sum, mitotic index of cancer cells, ascites volume are substantially reduced, and the cAMP level in cancer cell has Increase.6. anti-inflammatory effect: cordate houttuynia decoction is swollen to rat formaldehyde foot significant anti-inflammatory effect, can also significantly inhibit people γ-Ball AlbumenThermal denaturation in the presence of Cu++；Decanoy acetaldehyde can significantly inhibit croton oil, dimethylbenzene induced mice ear swelling, skin hair Thin vasopermeability increases, and also significantly inhibits contained by effect cordate houttuynia to the exudation of capillary dyestuff in abdominal cavity caused by HCAMongolian oak Pi Su, quercitrin and Isoquercitrin etc.Flavone compoundAlso there is significant anti-inflammatory effect, the capillary of inflammation early stage can be significantly inhibited Blood vessel is hyperfunction.7. other obvious effects of the antagonism slow reacting substance (SRS-A) to isolated guinea pig ileum of effect Herba Houttuyniae oils energy, The anaphylaxis of sensitized guinea pig Ileum From A White can be obviously inhibited to shrink, the contraction of antagonizing histamine, acetylcholine to guinea pig ileum, and There is significant protective effect to cavy allergic asthma.
(2) honeysuckle pharmacological actionStaphylococcus aureus、Hemolytic streptococcus, Escherichia coli,Shigella dysenteriae、Cholera arc Bacterium、Typhoid bacillus, paratyphosum Bacterium etc. have certain inhibiting effect, it is rightPneumococcus、Diplococcus meningitidis、Pseudomonas aeruginosa、Knot Core bacillusAlso effectively.Flooding agent is stronger than decoction effect, and leaf decoction is stronger than the effect of colored decoction.If sharing with Fructus Forsythiae, antibacterial range is also It can be complementary；WithPenicillinIt shares, penicillin can be reinforced to the antibacterial action of resistant Staphylococcus aureus, this may be to inhibit There is collaboration in the synthesis of bacterium vivo protein.2. anti-inflammatory and refrigeration function: intraperitoneal injection Flos Lonicerae extractive solution 0.25g/ Kg can inhibit Rat Carrageenan colloidality foot swollen.30~40g/kg of honeysuckle flower injection can mitigate the swollen journey of egg white foot according to another report Degree.Flos Lonicerae extractive solution 8g/kg is injected intraperitoneally, 2 times/day, continuous 6 days, to rat crotons oiliness granulation capsule, also has obvious impervious Out with the effect of anti-proliferate.Reporting honeysuckle has an apparent refrigeration function, but with cholera vaccine, bacillus mesentericus, withered Careless immersion liquid etc. is injected to family's rabbit ear vein, and pyrogenicity does not confirm that honeysuckle decoction 5g/kg stomach-filling has antipyretic effect, it is believed that this may It is different with the tolerance of the honeysuckle preparation, dosage or the rabbit that use related.3. booster immunization function acts on: honeysuckle decoction is dilute It releases to the concentration of 1:1280, remains to promoteLeucocytePhagocytic function.Mouse peritoneal injects honeysuckle flower injection, also there is obvious rush Into the effect of inflammatory cell phagocytic function.4. central excitation acts on: being taken orally through the kinds of experiments method such as electroconvulsive shock, rotating cage proof green After ortho acid, the animals such as rat, mouse can be causedCentral nervous systemExcitement, action intensity areCaffeine1/6, Papillary Without addition and humidification.5. effect for reducing blood fat: rat oral gavage honeysuckle 2.5g/kg can be reduced enteral cholesterol absorption, reduce Cholesterol level in blood plasma.Experiment in vitro is it has also been found that honeysuckle can combine with cholesterol, but Simiao Yongan Tang is (honeysuckle, profound Ginseng, Radix Angelicae Sinensis, Radix Glycyrrhizae) treatment rabbit experimentAtherosclerosis.Reducing blood lipid and Cholesterol concentration in aortic tissue content have not been observed Effect.6. antiendotoxin: usingLimulus testEndotoxin content is measured, 300% honeysuckle flower injection is with 1: 2~1: 64 dilutions, body No matter outer test uses female tab method or test tube method, the endotoxin content being substantially reduced in test solution, wherein 1: 2~1: 8 dilution tube It is in a liquid state as negative control pipe, positive control is in gel.Honeysuckle distillate 6g/kg intravenous injection, it is rightPseudomonas aeruginosa Rabbit temperature decline caused by the mutual 2.8mg/kg of endogenous toxic material is injected intravenously and leukocyte count decline have antagonism, honeysuckle distillate 7.5g/kg or injection 2.5g/kg intraperitoneal injection has protection to make the mouse of Pseudomonas aeruginosa endotoxin 65mg/kg intraperitoneal injection With reduction mouse death rate.7. other effects: the water and steeping in wine liquid for once having in-vitro screening laboratory report honeysuckle are to sarcoma 180 And ehrlich ascites cancer has apparent cytotoxicity.Honegsukle flower P.E is oral to have slight pre- preventive effect to Experimental Gastric Ulcer in Rats Fruit.N of high dose oral chlorogenic acid can increase gastrointestinal peristalsis, promote gastric juice and bile secretion.Chlorogenic acid and its decomposition product are to rat Isolated uterine has excitation.In addition, chlorogenic acid can also slightly enhanceAdrenalineAnd its norepinephrine is to cat and rat Boosting, but on the nictitating membrane response of cat without influence.
(3) elscholtiza pharmacological action: 1. volatile oil has broad-spectrum antiseptic and bactericidal effect, and has and directly inhibit influenza virus Effect.2. antivirus action: having inhibiting effect to viral ECHO11 plants when elsholtzia splendens water decoction 1:20 concentration.3. antibacterial work With: the product volatile oil to Escherichia coli,Staphylococcus aureusThere is bacteriostasis.When being measured with Beating holes method, concentration is 1: 200~1: 1000Inhibition zoneDiameter is 9mm.Its decocting liquid also has staphylococcus aureusIt is antibacterialEffect, is beaten with plate The measurement of hole method, when concentration is 1: 1.25, the diameter of inhibition zone is 15mm, antibacterial circle diameter when concentration 1: 1.25~1: 0.16 It is 9mm.Mosla Chinensis Maxim volatile oil is to staphylococcus aureus, meningitisDiplococcus、Typhoid bacillusIt is acted on etc. having compared with high inhibition.④ Effect in vitro intestinal smooth muscle: Herba Moslae volatile oil pairMouse, rat,CavyWith the Ileum From A White Spontaneous Contraction activity of rabbit All there is stronger direct repression, but to the sensibility of the animal of different genera difference, in contrast, cavy and rabbit are returned The inhibiting effect of intestines is stronger, and effective dose 50 is respectively 3.6 and 7.6 μ g/ml, and, half slightly weak to the effect of rat and mouse Effective quantity is 14.2 and 35.1 μ g/ml.To guinea pig ileum because caused by egg white anaphylaxis shrink andBarium chlorideCaused mistake Quick property contraction has antagonism.5. resisting pathogenic microbes, which acts on its volatile oil, has stronger inhibitory or killing effect to pathogenic microorganism Experiment shows: Herba Moslae volatile oil infected by influenza has certain inactivation capacity, inactivates concentration 1: 1000~1: 2 000；To gold Staphylococcus aureus, beta streptococcus, typhoid bacillus, FreundShigella dysenteriae, corynebacterium diphtheriae, diplococcus meningitidis, micrococcus catarrhalis, There are stronger antibacterial action, concentration 1: 4 000~1: 25 600.1: 2 000 elsholtzia oil is with 75% alcohol in processing sewage miscellaneous bacteria When have similar sterilization capability, 6min sterilization rate is respectively 99.2%, 99.36%；Antibacterial intensity (the golden yellow grape of elsholtzia oil Coccus, micrococcus catarrhalis, bacterium flexneri) it is higher than iodine solution, but be weak elscholtiza decoction (1: 20) than nitrofurazone and bromogeramine Effect is also significantly inhibited to Asia influenza A virus, capital section 68-1 Strain and orphan virus (ECHO11) in vitro.⑥ Other effects: experiment show Mosla Chinensis Maxim volatile oil to body non-specificity andSpecific immune functionSignificantly increase effect； To mouse,Rat, cavy and rabbit Ileum From A White Spontaneous Contraction significantly inhibit effect, it is rightEgg whiteCaused guinea pig ileum mistake Quick property, which is shunk, also significantly inhibits effect with guinea pig ileum spasmodic contraction caused by barium chloride；In addition, still having diuresis, antibechic and dispelling Phlegm effect elsholtzia splendens extract has significant suppression to angiotensin receptor and beta-hydroxy-Beta-methyl glutaric acid coacetylase in vitro Is used in production
The preparation method for the alleviation children's upper respiratory tract infection symptom oral solution that inventor provides is: it cleans respectively in advance, hot-air seasoning, Disinfection by ultraviolet light, the fresh cordate houttuynia of grind into powder, honeysuckle, each 1000g of elscholtiza are utilized with supercritical extract instrument super respectively Critical CO2It is extracted, obtains cordate houttuynia supercritical CO2Extract, honeysuckle supercritical CO2Extract, elscholtiza supercritical CO2 Extract, it is spare；Then flavour amino acid supercritical CO is taken2Extract, honeysuckle supercritical CO2Extract, elscholtiza supercritical CO2 Each 1 part of extract, every 1 part of quality is below 1000g, mixing；The Tween-80 that mixture gross mass 0.1%~5% is added helps It is molten, add water for injection or pure water to carry out ultrafiltration membrance filter, be made into 1000ml, it is filling at oral solution to get.
The oral solution usage of alleviation children's upper respiratory tract infection symptom of the invention is oral, each 5~20mL of dosage, often Day 2~3 times.
The oral solution of alleviation children's upper respiratory tract infection symptom of the invention is to practice the formula obtained in long term medical.This Health food of the Alevaire as adjuvant treatment, cooperation Chinese and western medical have clearing heat-fire, diuresis for children's upper respiratory tract infection Clearing damp, eliminating inflammation and expelling toxin function, total effective rate is 95% or more.The heavy cold patient of adult is also had obvious effects on.This The oral solution of invention is easy to infant taking, can reduce the symptom and pain of patient.Suitable for feeling on adjuvant treatment children.
Specific embodiment
Embodiment takes to be cleaned respectively in advance, hot-air seasoning, disinfection by ultraviolet light, the fresh cordate houttuynia of grind into powder, gold Honeysuckle flower, each 1000g of elscholtiza utilize supercritical CO with supercritical extract instrument respectively2It is extracted, obtains cordate houttuynia supercritical CO2 Extract, honeysuckle supercritical CO2Extract, elscholtiza supercritical CO2Extract, it is spare；
Take flavour amino acid supercritical CO2Extract, honeysuckle supercritical CO2Extract, elscholtiza supercritical CO2Each 1 part of extract, Every 1 part of quality is 100g, mixing；The Tween-80 hydrotropy of mixture gross mass 0.1%~5% is added, adds water for injection or pure Water carries out ultrafiltration membrance filter, is made into 1000ml, filling to get the oral solution for alleviating children's upper respiratory tract infection symptom.

Claims (3)

1. a kind of oral solution for alleviating children's upper respiratory tract infection symptom, it is characterised in that the oral solution is by following 3 kinds of medicinal materials: Cordate houttuynia, honeysuckle, elscholtiza, pass through supercritical CO2The extract being obtained by extraction adds cosolvent and pure water, is made through ultrafiltration 's.
2. oral solution as described in claim 1, it is characterised in that the cosolvent is Tween-80.
3. the method for preparing oral solution described in claim 1, it is characterized in that clean respectively in advance, hot-air seasoning, disinfection by ultraviolet light, The fresh cordate houttuynia of grind into powder, honeysuckle, each 0~1000g of elscholtiza utilize supercritical CO with supercritical extract instrument respectively2 It is extracted, obtains cordate houttuynia supercritical CO2Extract, honeysuckle supercritical CO2Extract, elscholtiza supercritical CO2Extract, It is spare；Then flavour amino acid supercritical CO is taken2Extract, honeysuckle supercritical CO2Extract, elscholtiza supercritical CO2Extract is each 1 part, every 1 part of quality is below 1000g, mixing；The Tween-80 hydrotropy of mixture gross mass 0.1%~5% is added, filling is penetrated Carry out ultrafiltration membrance filter with water or pure water, be made into 1000ml, it is filling to get.
CN201811219579.5A 2018-10-19 2018-10-19 A kind of oral solution for alleviating children's upper respiratory tract infection symptom Withdrawn CN109010487A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111407817A (en) * 2020-05-18 2020-07-14 赖宇 Traditional Chinese medicine composition for preventing respiratory tract infection pathogenic microorganisms and preparation method thereof

Citations (4)

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Publication number Priority date Publication date Assignee Title
CN1615923A (en) * 2003-11-12 2005-05-18 成都三明药物研究所 Medicinal composition and its preparing method and use
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Application publication date: 20181218