CN104758555A - Chinese herbal medicine for curing marine fish bacterial diseases - Google Patents
Chinese herbal medicine for curing marine fish bacterial diseases Download PDFInfo
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- CN104758555A CN104758555A CN201510200763.5A CN201510200763A CN104758555A CN 104758555 A CN104758555 A CN 104758555A CN 201510200763 A CN201510200763 A CN 201510200763A CN 104758555 A CN104758555 A CN 104758555A
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Abstract
The invention relates to Chinese herbal medicine for curing marine fish bacterial diseases. The Chinese herbal medicine is decoction prepared, by weight, by the following raw materials of 4-6 parts of tobacco leaves, 4-6 parts of onion, 3-4 parts of pericarpium citri reticulatae, 3-4 parts of mentha haplocalyx, 3-4 parts of eucalyptus leaves, 2-4 parts of acorus calamus, 2-4 parts of gallnut and 0.5-1 part of alum. The Chinese herbal medicine for curing the marine fish bacterial diseases has the advantages of being high in cure rate, good in effect, safe, free of toxic and side effect and convenient to use.
Description
Technical field
The present invention relates to marine fish culture Chinese herbal medicine, specifically relate to a kind of Chinese herbal medicine for the treatment of seawater fish bacterial disease.
Background technology
In recent years the disease in seawater fish industrialized culture comparatively significantly increased before 10 years, and many new diseases constantly occur, and treat more and more difficult.The problems such as at present, dipping prevents and treats fish bacteria disease and generally adopts the Western medicine such as formalin, tetramycin hydrochloride solution, exists and easily causes skin, Sai Si tissue injury, even damage the function of each internal organs, and convalescent period is long; And Chinese herb bath can avoid the problems referred to above, there is instant effect, have no side effect, cost-saving feature, have effect of antiviral, anti-bacteria, anti-various stress, enhancing human body immunity power, and have natural sex, toxic and side effects is little and without drug-fast advantage.Prior art not yet discloses the Chinese herbal medicine effectively can treating seawater fish bacterial disease.
Summary of the invention
The object of the invention is to for the problems referred to above, a kind of Chinese herbal medicine effectively can treating seawater fish bacterial disease is provided.
Technical scheme of the present invention is: a kind of Chinese herbal medicine for the treatment of seawater fish bacterial disease, and it is the decoction be made up of the raw material of following weight parts: Nicotiana tabacum L. 4-6 part, Bulbus Allii Cepae 4-6 part, Pericarpium Citri Reticulatae 3-4 part, Herba Menthae 3-4 part, eucalyptus leaves 3-4 part, Rhizoma Acori Graminei 2-4 part, Galla Chinensis 2-4 part, Alumen 0.5-1 part.
Making the preferred feedstock weight portion that the present invention treats the Chinese herbal medicine of seawater fish bacterial disease is: 4 parts, Nicotiana tabacum L., Bulbus Allii Cepae 4.5 parts, Pericarpium Citri Reticulatae 4 parts, Herba Menthae 3 parts, eucalyptus leaves 3 parts, Rhizoma Acori Graminei 3 parts, Galla Chinensis 3 parts, 0.5 part, Alumen.
In prescription of the present invention, each component pharmacological effect is:
Nicotiana tabacum L. effect: Nicotiana tabacum L. another name cigarette, nature and flavor are pungent, warm, return lung meridian.Containing alkaloid and globulariacitrin, organic acid (malic acid, citric acid), fat, resin, inanimate matter and clionasterol glycoside, ring Ben Boluo enol.Tool promoting the circulation of QI to relieve pain, effect of removing toxic substances parasite killing.Glutted for dyspepsia, depressed pain, carbuncle, furuncle, scabies.
Bulbus Allii Cepae effect: Bulbus Allii Cepae another name Bulbus Allii Cepae, Onion, onion, onion, ball Herba Alii fistulosi.Nature and flavor temperature, sweet, pungent, return liver, spleen, lung, stomach warp.Containing volatile oil, be rich in allicin, mercaptan, trisulfide etc. and caffeic acid, sinapic acid, cinnamic acid, citrate, polysaccharide and several amino acids.Tool eliminates the phlegm diuresis, stomach-invigorating intestine-moisturizing, effect of removing toxic substances parasite killing.For inappetence, stool is not smooth, dysentery enteritis, abdominal pain due to worm stagnation, trauma ulcer etc.
Pericarpium Citri Reticulatae effect: Pericarpium Citri Reticulatae another name Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, extensively Pericarpium Citri tangerinae, Pericarpium Citri tangerinae.Nature and flavor temperature, pungent, bitter, return spleen, lung meridian.Red Fructus Citri tangerinae fruit is containing volatile oil and hesperidin, Nobiletin, inositol.Main containing limonene in volatile oil, and containing australene, nopinene, β-phellandrene, paracymene, α-terpinene, linalool and linalyl acetate.Sarcocarp is containing citric acid and reducing sugar.Tool invigorating the spleen and regulating the stomach, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, effect of lowering the adverse-rising QI and eliminating phlegm.For stagnation of QI in spleen and stomach, gastral cavity abdomen covers with, nausea and vomiting, inappetence, cough with copious phlegm etc.
Herba Menthae effect: Herba Menthae another name wild mint, night cease fragrant.Nature and flavor are pungent, cool, return lung, Liver Channel.Containing acetic acid peppermint ester, camphene, limonene, isomenthone, pinene, piperitenone, resin and a small amount of tannin, rosmarinic acid; Stem and leaf is containing volatile oil, main containing l-menthol in oil, secondly containing l-menthone.Another containing multiple free amino acids such as isomenthone, pulegone, decyl acetate, menthyl acetate, Menthyl, australene, amyl alcohol-3, nopinene, β-thujene, hexanol-2, d-myrcene, limonene, capryl alcohol-3, cineole and alpha-terpineol and Soviet Union ammonia, alanine, glutamic acid, agedoites.Tool dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, effect of soothing the liver circulation of qi promoting.For affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.
Eucalyptus leaves effect: eucalyptus leaves another name Eucalyptus globulus Labill leaf, sheep amomum tsaoko leaf.Cold in nature, bitter in the mouth.Return lung, stomach, spleen, Liver Channel.Leaf and Hua Jun are containing volatile oil, and its Main Ingredients and Appearance is 1, 8-Cineole, pinene, aromadendrene, cumaldehyde, 10-Pinen-3-ol and 1-acetyl-4-isopropylidene cyclopentenes etc.Leaf containing globulariacitrin, quercitrin, Quercetin, L (+)-homoserine, also separates Eucalyptin again.Bark is containing tannin.From the tar that this plant obtains, containing guaiacol.Eucalyptus globulus quintessence oil is one of best antibacterial, has very strong sterilizing power, also has the effect reducing mucous viscosity in body simultaneously, can relax inflammation phenomenon and make mucosa comfortable.Can be used for dysentery, enteritis, scabies, eczema, carbuncle pyogenic infections from tumour or sore etc.
Rhizoma Acori Graminei effect: Rhizoma Acori Graminei has another name called smelly Rhizoma Acori Graminei, Rhizoma Acori Calami, mud Rhizoma Acori Graminei, great Ye Rhizoma Acori Graminei, calamus.For aquatic herbaceous plant for many years.Warm in nature, acrid in the mouth, hardship.GUIXIN, stomach warp.Containing α-, beta-Asarone, cis-Methylisoeugenol, methyleugenol, Rhizoma Acori Graminei enediol, Rhizoma Acori Graminei helicene ketone, acolamone, acorone, the large bull ketone of Rhizoma Acori Graminei, acorone, isoacrone etc.Tool a surname gas, removing toxic substances, parasite killing, effect of stomach invigorating.For abdominal distention, enteritis, ectozoa etc.
Galla Chinensis effect: Galla Chinensis another name Folium rhois chinensis, upper Balls, paint gall nut, red-leaf peach, non-irrigated gall nut, Wu Yanpao.Nature and flavor are trembled with fear, sour, puckery; Return lung, large intestine, kidney channel.Containing Gallotannin, comprise the multiple glucoses such as galloyl-beta-D-glucose.Tool is astringed the lung, hidroschesis, astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, hemostasis, effect of removing toxic substances.For chronic cough of deficiency lung, spontaneous sweating, chronic dysentery chronic diarrhea, proctoptosis, various hemorrhage, carbuncle furuncle.
Alumen effect: Alumen another name Alumen, arcanite, potassium aluminium alum, potassium alum; Nature and flavor are sour and astringent, cold.Be included into lung, spleen, stomach, large intestine channel.Alunite is alkaline potassium aluminum sulfate, wherein potassium oxide, aluminium oxide, sulfur trioxide.Tool expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, effect of parasite killing.For sore throat, hepatitis, jaundice, general edema with yellowish skin, taste-blindness rate.
Prescription foundation of the present invention: Chinese herbal medicine contains various bioactivators and natural nutrient substance, can promote the synthesis of Fish organism metabolism and protein and enzyme, and anti-inflammation, parasite killing benefit body, improves immunity and the anti-stress ability of body, promote the growth of Fish.Nicotiana tabacum L., Bulbus Allii Cepae, Pericarpium Citri Reticulatae tool promote qi circulation digestion promoting in side, effect of spleen benefiting and stimulating the appetite; Bulbus Allii Cepae, Pericarpium Citri Reticulatae, Herba Menthae have special abnormal smells from the patient, and have food calling, appetite stimulator effect, Herba Menthae also has osmosis; Eucalyptus leaves, Rhizoma Acori Graminei, Galla Chinensis, Alumen can antiviral property, bacillary, fungoid and parasite type disease; Alumen has unique absorption property, the impurity that can suspend in adsorbed water, and forms precipitation, makes clarification of water, increases oxygen in water, improve water body intensity of photosynthesis, can purify water; And each crude drug itself, containing certain nutrient substance, as each seed amino acid, vitamin, trace element etc. that crude drug contains, can improve the nutrition of feedstuff, improve food conversion ratio in prescription; In prescription all medicine phases and, appetite, anti-inflammation, parasite killing benefit body can be promoted, improve immunity of organisms and resistance against diseases, the growth of accelerating fish.
The present invention treats the Chinese herbal medicine of seawater fish bacterial disease, is on the basis of carrying out a large amount of practical application, according to traditional medicine ancient prescription, forms in conjunction with physiology of fishes and immunologic theory screening.Raw material sources used herein are extensive, low price, and meanwhile, Chinese herbal medicine production technology of the present invention is very simple, is suitable as dip and uses.This Chinese herbal medicine is used for marine fish, and short long protection effect is good, and cost is low, easy to use.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment:
Take raw material respectively: Nicotiana tabacum L. 160g, Bulbus Allii Cepae 180g, Pericarpium Citri Reticulatae 160g, Herba Menthae 120g, eucalyptus leaves 120g, Rhizoma Acori Graminei 120g, Galla Chinensis 120g, Alumen 20g.
The preparation method of the Chinese herbal medicine of this treatment marine fish bacterial disease is: take Nicotiana tabacum L., Bulbus Allii Cepae, Pericarpium Citri Reticulatae, Herba Menthae, eucalyptus leaves, Rhizoma Acori Graminei, Galla Chinensis, Alumen by weight, and be ground into coarse powder respectively; Get Bulbus Allii Cepae, Pericarpium Citri Reticulatae, eucalyptus leaves, Herba Menthae coarse powder, collect the volatile oil distilled out with steam distillation; Separately get Nicotiana tabacum L., Rhizoma Acori Graminei, Galla Chinensis, Alumen four taste coarse powder, slow fire boiling together with the Bulbus Allii Cepae after distillation, Pericarpium Citri Reticulatae, eucalyptus leaves, Herba Menthae medicinal residues after soaking; Filter, obtain first-time filtrate; Get the medicinal residues after first-time filtrate and decoct with water secondary again, obtain secondary filtrate and three filtrates respectively; Merge three filtrates, be heated as concentrated solution; Volatile oil and concentrated solution being merged, by quantitatively adding antiseptic, stirring evenly, filter, fill, sterilizing, obtains the Chinese herbal medicine of this treatment seawater fish bacterial disease.
1, Chinese herbal medicine of the present invention double sliding-tongue sole common bacteria drug sensitive test
Choosing clinical ill Cynoglossus semilaevis fish respectively through being separated, identifying pathogen is vibrio parahaemolytious, Edwardsiella tarda, this Salmonella of anguilla japonica, gets a certain amount of Chinese herbal medicine of the present invention, and every mL is containing crude drug 1g, and sterilizing, subpackage, 4 DEG C save backup.
Medicament sensitivity test: adopt plate punch method, the vibrio parahaemolytious of clinical separation, Vibro harveyi, this Salmonella of anguilla japonica are first inoculated on flat board, in hole, add the liquid that 1g/mL is made up of herbal prescription of the present invention, be not advisable outside overfolw hole to fill it up with.18h is cultivated in 28 DEG C.Be placed in 28 DEG C of constant incubators and cultivate 2h, measure antibacterial circle diameter, and compare in traditional formalin 0.1%.Criterion: according to " pharmacology of Chinese materia medica " standard with " U.S. clinical Laboratory Standard institute version in 2005 is about drug sensitive test standardization ", namely bacteriostatic diameter >=20mm is extremely quick, and 20mm> bacteriostatic diameter >=15mm is Gao Min; 15mm> bacteriostatic diameter >=10mm is quick in being, below 10mm is hypoallergenic.
Chinese herbal medicine sensitivity tests comparing result of the present invention is in table 1.
Table 1 Chinese herbal medicine sensitivity tests of the present invention comparing result (24 hours) mm
Table 1 shows, Chinese herbal medicine of the present invention reaches 18.5 respectively to vibrio parahaemolytious, Vibro harveyi, this Salmonella bacteriostatic diameter of anguilla japonica, 19.0,21.0mm, higher than formaldehyde contrast effect, Chinese herbal medicine of the present invention is to better by vibrio parahaemolytious, Vibro harveyi, the microbial infectious effect of this Dun Shi of anguilla japonica.
Artificial challenge's Cynoglossus semilaevis fish Vibro harveyi morbidity effect clinical trial: long 20 centimetres of about the 30 grams Cynoglossus semilaevis fishes of 180 urosomes are divided into 6 groups at random, and often organize 30 tails, grouping and processing method are in table 2.
Table 2 tests grouping and processing method (unit: tail)
Except normal healthy controls group Cynoglossus semilaevis fish injection sterile saline 0.2mL, all the other are respectively organized every tail Cynoglossus semilaevis fish and all inject Vibro harveyi (3 × 10
6individual/mL) 0.2mL.Test fish (except normal healthy controls group) food ration after counteracting toxic substances 48h to reduce, vigor weakens, and skin engenders and little ulcer, hemorrhage occur ascites, and matched group do not show above-mentioned symptom.Start by table 2 dosed administration, observe the clinical change after administration, record clinical symptoms and the death toll of each group of fish every day.Experimental result is in table 3.
The therapeutic outcome of table 3 Experimental infection (unit: only, %)
As shown in Table 3, the high, medium and low dosage group of Chinese herbal medicine of the present invention is compared with infection matched group, and cure rate inequality heteropole significantly (P<0.01); High, the middle dosage group of this Chinese herbal medicine compares with formalin treatment group, cure rate significant difference (P<0.05); The cure rate of low dose group and formalin treatment group comparing difference are not significantly (P>0.05).
2, clinical trial after the morbidity of Cynoglossus semilaevis fish natural infection Vibro harveyi
Fish is provided by each raiser in Changli County, Hebei province natural infection Vibro harveyi morbidity Cynoglossus semilaevis respectively, and Cynoglossus semilaevis fish divides into groups, is equal to Experimental infection by middle dosed administration, observation of symptoms.Therapeutic outcome is in table 4.
The therapeutic effect of table 4 natural infection (unit: gram, tail, %)
By Cynoglossus semilaevis fish Ureteral Calculus of falling ill to natural infection Vibro harveyi, Chinese herbal treatment group of the present invention has significant effect to the sick fish treatment of natural infection Vibro harveyi, average cure rate is 93.6%, generally through the sick fish rehabilitation of 5 ~ 7d, recover normally to search for food and vigor, and dispensing whole process has no fish and has any untoward reaction.
Claims (2)
1. treat a Chinese herbal medicine for seawater fish bacterial disease, it is characterized in that it is the decoction be made up of the raw material of following weight parts: Nicotiana tabacum L. 4-6 part, Bulbus Allii Cepae 4-6 part, Pericarpium Citri Reticulatae 3-4 part, Herba Menthae 3-4 part, eucalyptus leaves 3-4 part, Rhizoma Acori Graminei 2-4 part, Galla Chinensis 2-4 part, Alumen 0.5-1 part.
2. the Chinese herbal medicine for the treatment of seawater fish bacterial disease according to claim 1, is characterized in that it is the decoction be made up of the raw material of following weight parts: 4 parts, Nicotiana tabacum L., Bulbus Allii Cepae 4.5 parts, Pericarpium Citri Reticulatae 4 parts, Herba Menthae 3 parts, eucalyptus leaves 3 parts, Rhizoma Acori Graminei 3 parts, Galla Chinensis 3 parts, 0.5 part, Alumen.
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| CN105327318A (en) * | 2015-11-27 | 2016-02-17 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating bacterial gill-rot disease of ictalurus punctatus and preparation method of feed additive |
| CN111759950A (en) * | 2019-12-16 | 2020-10-13 | 四川成康动物药业有限公司 | Composite probiotic fermentation product for preventing and treating aquatic vibriosis |
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| CN102845650A (en) * | 2012-09-28 | 2013-01-02 | 河北科技师范学院 | Chinese herbal medicine feed additive for enhancing growth and preventing diseases of carp |
| CN102934745A (en) * | 2012-09-28 | 2013-02-20 | 河北科技师范学院 | Carp and crucian Chinese herbal phagostimulant and preparation method thereof |
| CN102961660A (en) * | 2012-12-14 | 2013-03-13 | 张�杰 | Chinese herbal medicine for treating fish diseases |
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| CN102845650A (en) * | 2012-09-28 | 2013-01-02 | 河北科技师范学院 | Chinese herbal medicine feed additive for enhancing growth and preventing diseases of carp |
| CN102934745A (en) * | 2012-09-28 | 2013-02-20 | 河北科技师范学院 | Carp and crucian Chinese herbal phagostimulant and preparation method thereof |
| CN102961660A (en) * | 2012-12-14 | 2013-03-13 | 张�杰 | Chinese herbal medicine for treating fish diseases |
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| CN105327318A (en) * | 2015-11-27 | 2016-02-17 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating bacterial gill-rot disease of ictalurus punctatus and preparation method of feed additive |
| CN111759950A (en) * | 2019-12-16 | 2020-10-13 | 四川成康动物药业有限公司 | Composite probiotic fermentation product for preventing and treating aquatic vibriosis |
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