CN104758555B - Treat the Chinese herbal medicine of seawater fish bacterial disease - Google Patents
Treat the Chinese herbal medicine of seawater fish bacterial disease Download PDFInfo
- Publication number
- CN104758555B CN104758555B CN201510200763.5A CN201510200763A CN104758555B CN 104758555 B CN104758555 B CN 104758555B CN 201510200763 A CN201510200763 A CN 201510200763A CN 104758555 B CN104758555 B CN 104758555B
- Authority
- CN
- China
- Prior art keywords
- parts
- herbal medicine
- chinese herbal
- bacterial disease
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 27
- 241000411851 herbal medicine Species 0.000 title claims abstract description 23
- 208000035143 Bacterial infection Diseases 0.000 title claims abstract description 14
- 208000022362 bacterial infectious disease Diseases 0.000 title claims abstract description 14
- 239000013535 sea water Substances 0.000 title claims abstract description 14
- 244000205574 Acorus calamus Species 0.000 claims abstract description 18
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims abstract description 18
- 235000011996 Calamus deerratus Nutrition 0.000 claims abstract description 18
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 15
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 15
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 15
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 15
- 244000166124 Eucalyptus globulus Species 0.000 claims abstract description 14
- 229940037003 alum Drugs 0.000 claims abstract description 13
- 240000003152 Rhus chinensis Species 0.000 claims abstract description 12
- 235000014220 Rhus chinensis Nutrition 0.000 claims abstract description 12
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 11
- 244000061176 Nicotiana tabacum Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 244000291564 Allium cepa Species 0.000 claims abstract 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000014347 soups Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 26
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241000234282 Allium Species 0.000 description 15
- 239000003814 drug Substances 0.000 description 14
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 11
- 229940079593 drug Drugs 0.000 description 10
- 241000607618 Vibrio harveyi Species 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000000341 volatile oil Substances 0.000 description 8
- 241001014350 Cynoglossus semilaevis Species 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000607142 Salmonella Species 0.000 description 5
- 235000019789 appetite Nutrition 0.000 description 5
- 230000036528 appetite Effects 0.000 description 5
- -1 clionasterol glycoside Chemical class 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 4
- 241000607598 Vibrio Species 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000252082 Anguilla anguilla Species 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 208000004232 Enteritis Diseases 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- NFLGAXVYCFJBMK-IUCAKERBSA-N (-)-isomenthone Chemical compound CC(C)[C@@H]1CC[C@H](C)CC1=O NFLGAXVYCFJBMK-IUCAKERBSA-N 0.000 description 2
- AGUISGUERLMHFF-PKIAMQTDSA-N (1s,4r,5s,8r)-1,8-dimethyl-4-propan-2-ylspiro[4.5]decane-3,9-dione Chemical compound CC(C)[C@H]1C(=O)C[C@H](C)[C@]11CC(=O)[C@H](C)CC1 AGUISGUERLMHFF-PKIAMQTDSA-N 0.000 description 2
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 2
- NHMMAMIRMITGRD-UHFFFAOYSA-N 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-6,8-dimethylchromen-4-one Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(O)C(C)=C(OC)C(C)=C2O1 NHMMAMIRMITGRD-UHFFFAOYSA-N 0.000 description 2
- LAEJTNRXQGCKMM-UHFFFAOYSA-N Acorone Natural products CC(C)C1CC(=O)C(C)C12CCC(C)C(=O)C2 LAEJTNRXQGCKMM-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Chinese gallotannin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- NUPSHWCALHZGOV-UHFFFAOYSA-N Decyl acetate Chemical compound CCCCCCCCCCOC(C)=O NUPSHWCALHZGOV-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- TYQALBNCJWAILN-GZBFAFLISA-N acolamone Chemical compound C1CCC(=C)[C@@H]2C(=O)[C@H](C(C)C)CC[C@]21C TYQALBNCJWAILN-GZBFAFLISA-N 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229930006722 beta-pinene Natural products 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- WTWBUQJHJGUZCY-UHFFFAOYSA-N cuminaldehyde Chemical compound CC(C)C1=CC=C(C=O)C=C1 WTWBUQJHJGUZCY-UHFFFAOYSA-N 0.000 description 2
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 description 2
- AGUISGUERLMHFF-UHFFFAOYSA-N epiacorone Natural products CC(C)C1C(=O)CC(C)C11CC(=O)C(C)CC1 AGUISGUERLMHFF-UHFFFAOYSA-N 0.000 description 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- NFLGAXVYCFJBMK-UHFFFAOYSA-N isomenthone Natural products CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 2
- 229940087305 limonene Drugs 0.000 description 2
- 235000001510 limonene Nutrition 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 201000002266 mite infestation Diseases 0.000 description 2
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 2
- HKZQJZIFODOLFR-UHFFFAOYSA-N piperitenone Chemical compound CC(C)=C1CCC(C)=CC1=O HKZQJZIFODOLFR-UHFFFAOYSA-N 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 2
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 2
- 235000005493 rutin Nutrition 0.000 description 2
- 229960004555 rutoside Drugs 0.000 description 2
- PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Chemical compound O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- YHQGMYUVUMAZJR-UHFFFAOYSA-N α-terpinene Chemical compound CC(C)C1=CC=C(C)CC1 YHQGMYUVUMAZJR-UHFFFAOYSA-N 0.000 description 2
- WTARULDDTDQWMU-UHFFFAOYSA-N β-pinene Chemical compound C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 description 2
- NZGWDASTMWDZIW-MRVPVSSYSA-N (+)-pulegone Chemical compound C[C@@H]1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-MRVPVSSYSA-N 0.000 description 1
- LFJQCDVYDGGFCH-JTQLQIEISA-N (+)-β-phellandrene Chemical compound CC(C)[C@@H]1CCC(=C)C=C1 LFJQCDVYDGGFCH-JTQLQIEISA-N 0.000 description 1
- LFJQCDVYDGGFCH-SNVBAGLBSA-N (+/-)-beta-Phellandrene Natural products CC(C)[C@H]1CCC(=C)C=C1 LFJQCDVYDGGFCH-SNVBAGLBSA-N 0.000 description 1
- TYQALBNCJWAILN-UHFFFAOYSA-N (-)-(2R,4aS,8aR)-4a-methyl-8-methylene-2-(1-methylethyl)-octahydro-2H-naphthalen-1-one Natural products C1CCC(=C)C2C(=O)C(C(C)C)CCC21C TYQALBNCJWAILN-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- ITYNGVSTWVVPIC-DHGKCCLASA-N (-)-allo-Aromadendrene Chemical compound C([C@@H]1[C@H]2C1(C)C)CC(=C)[C@@H]1[C@H]2[C@H](C)CC1 ITYNGVSTWVVPIC-DHGKCCLASA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- WUOACPNHFRMFPN-SECBINFHSA-N (S)-(-)-alpha-terpineol Chemical compound CC1=CC[C@@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-SECBINFHSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 125000002006 1,8-cineol group Chemical group 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000010470 Ageusia Diseases 0.000 description 1
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 description 1
- 241001346334 Amomum tsao-ko Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 208000031868 Calculus ureteric Diseases 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- KZJWDPNRJALLNS-FBZNIEFRSA-N Clionasterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-FBZNIEFRSA-N 0.000 description 1
- 208000034657 Convalescence Diseases 0.000 description 1
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229930185299 Eucalyptin Natural products 0.000 description 1
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 description 1
- WSTYNZDAOAEEKG-UHFFFAOYSA-N Mayol Natural products CC1=C(O)C(=O)C=C2C(CCC3(C4CC(C(CC4(CCC33C)C)=O)C)C)(C)C3=CC=C21 WSTYNZDAOAEEKG-UHFFFAOYSA-N 0.000 description 1
- 240000007707 Mentha arvensis Species 0.000 description 1
- 235000018978 Mentha arvensis Nutrition 0.000 description 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- OBIOZWXPDBWYHB-UHFFFAOYSA-N Nobiletin Natural products C1=CC(OC)=CC=C1C1=C(OC)C(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 OBIOZWXPDBWYHB-UHFFFAOYSA-N 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 240000000275 Persicaria hydropiper Species 0.000 description 1
- 235000017337 Persicaria hydropiper Nutrition 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- NZGWDASTMWDZIW-UHFFFAOYSA-N Pulegone Natural products CC1CCC(=C(C)C)C(=O)C1 NZGWDASTMWDZIW-UHFFFAOYSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 description 1
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 208000000014 Ureteral Calculi Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 description 1
- 235000010081 allicin Nutrition 0.000 description 1
- OVKDFILSBMEKLT-UHFFFAOYSA-N alpha-Terpineol Natural products CC(=C)C1(O)CCC(C)=CC1 OVKDFILSBMEKLT-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229940088601 alpha-terpineol Drugs 0.000 description 1
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 description 1
- USMNOWBWPHYOEA-UHFFFAOYSA-N alpha-thujone Natural products CC1C(=O)CC2(C(C)C)C1C2 USMNOWBWPHYOEA-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000011126 aluminium potassium sulphate Nutrition 0.000 description 1
- 229910052934 alunite Inorganic materials 0.000 description 1
- 239000010424 alunite Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- UIDUJXXQMGYOIN-UHFFFAOYSA-N aromadendrin Natural products CC1(C)C2C1CCC(C)C1C2C(C)CC1 UIDUJXXQMGYOIN-UHFFFAOYSA-N 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- RKFAZBXYICVSKP-UHFFFAOYSA-N beta- asarone Natural products COC1=CC(OC)=C(C=CC)C=C1OC RKFAZBXYICVSKP-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- RKFAZBXYICVSKP-WAYWQWQTSA-N beta-asarone Chemical compound COC1=CC(OC)=C(\C=C/C)C=C1OC RKFAZBXYICVSKP-WAYWQWQTSA-N 0.000 description 1
- LFJQCDVYDGGFCH-UHFFFAOYSA-N beta-phellandrene Natural products CC(C)C1CCC(=C)C=C1 LFJQCDVYDGGFCH-UHFFFAOYSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- GJYKUZUTZNTBEC-UHFFFAOYSA-N beta-thujene Chemical compound CC1C=CC2(C(C)C)C1C2 GJYKUZUTZNTBEC-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- NNWHUJCUHAELCL-UHFFFAOYSA-N cis-Methyl isoeugenol Natural products COC1=CC=C(C=CC)C=C1OC NNWHUJCUHAELCL-UHFFFAOYSA-N 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- NNWHUJCUHAELCL-PLNGDYQASA-N cis-isomethyleugenol Chemical compound COC1=CC=C(\C=C/C)C=C1OC NNWHUJCUHAELCL-PLNGDYQASA-N 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229940084434 fungoid Drugs 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 229920002824 gallotannin Polymers 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 229960001867 guaiacol Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- SEZLYIWMVRUIKT-UHFFFAOYSA-N isopiperitenone Natural products CC(=C)C1CCC(C)=CC1=O SEZLYIWMVRUIKT-UHFFFAOYSA-N 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 150000002729 menthone derivatives Chemical class 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 229940116837 methyleugenol Drugs 0.000 description 1
- PRHTXAOWJQTLBO-UHFFFAOYSA-N methyleugenol Natural products COC1=CC=C(C(C)=C)C=C1OC PRHTXAOWJQTLBO-UHFFFAOYSA-N 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- MRIAQLRQZPPODS-UHFFFAOYSA-N nobiletin Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 MRIAQLRQZPPODS-UHFFFAOYSA-N 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- NMRPBPVERJPACX-UHFFFAOYSA-N octan-3-ol Chemical compound CCCCCC(O)CC NMRPBPVERJPACX-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229930007459 p-menth-8-en-3-one Natural products 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229930006721 pinocarveol Natural products 0.000 description 1
- LCYXQUJDODZYIJ-UHFFFAOYSA-N pinocarveol Chemical compound C1C2C(C)(C)C1CC(O)C2=C LCYXQUJDODZYIJ-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229940050271 potassium alum Drugs 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- GNHOJBNSNUXZQA-UHFFFAOYSA-J potassium aluminium sulfate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GNHOJBNSNUXZQA-UHFFFAOYSA-J 0.000 description 1
- CHWRSCGUEQEHOH-UHFFFAOYSA-N potassium oxide Chemical compound [O-2].[K+].[K+] CHWRSCGUEQEHOH-UHFFFAOYSA-N 0.000 description 1
- 229910001950 potassium oxide Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 description 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 description 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 1
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- KPZTWMNLAFDTGF-UHFFFAOYSA-D trialuminum;potassium;hexahydroxide;disulfate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O KPZTWMNLAFDTGF-UHFFFAOYSA-D 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of Chinese herbal medicine for treating seawater fish bacterial disease, and it is the decoction made of the raw material of following weight parts：46 parts of tobacco leaf, 46 parts of onion, 34 parts of dried orange peel, 34 parts of peppermint, 34 parts of eucalyptus leaves, 24 parts of calamus, 24 parts of Chinese gall, 0.5 1 parts of alum.The present invention has the characteristics of cure rate is high, effect is good, safe and free of toxic and side effects, easy to use to treat seawater fish bacterial disease.
Description
Technical field
The present invention relates to marine fish culture Chinese herbal medicine, is specifically related to a kind of medium-height grass for treating seawater fish bacterial disease
Medicine.
Background technology
In recent years it is significantly increased before the disease in seawater fish industrial aquaculture was compared with 10 years, many new diseases continuously emerge,
And treatment is more and more difficult.At present, dipping preventing and treating fish bacteria disease is generally using west such as formalin, occrycetin solution
Medicine, exist and easily cause skin, cheek silk tissue damage, or even the function of each internal organs of infringement, the problems such as convalescence is long；And Chinese herb bath
Above mentioned problem can be avoided, have quick, had no toxic side effect, it is cost-effective the characteristics of, have it is antiviral, suppress bacterium, be anti-each
The effect of kind of stress reaction, enhancing immunity of organisms, and have natural sex, toxic side effect are small and the advantages of without the resistance to the action of a drug.It is existing
Technology not yet discloses the Chinese herbal medicine that can effectively treat seawater fish bacterial disease.
The content of the invention
It is an object of the invention in view of the above-mentioned problems, providing a kind of medium-height grass that can effectively treat seawater fish bacterial disease
Medicine.
The technical scheme is that：A kind of Chinese herbal medicine for treating seawater fish bacterial disease, it is by following weight parts
Decoction made of raw material：Tobacco leaf 4-6 parts, onion 4-6 parts, dried orange peel 3-4 parts, peppermint 3-4 parts, eucalyptus leaves 3-4 parts, calamus 2-4 parts,
Chinese gall 2-4 parts, alum 0.5-1 parts.
The preferred feedstock parts by weight of the Chinese herbal medicine of present invention treatment seawater fish bacterial disease, which are made, is：4 parts of tobacco leaf, onion
4.5 parts, 4 parts of dried orange peel, 3 parts of peppermint, 3 parts of eucalyptus leaves, 3 parts of calamus, 3 parts of Chinese gall, 0.5 part of alum.
Each component pharmacological effect is in prescription of the present invention：
Tobacco leaf effect：Tobacco leaf alias cigarette, nature and flavor are pungent, warm, return lung warp.Containing alkaloid and rutin, organic acid (malic acid,
Citric acid), fat, resin, inanimate matter and clionasterol glycoside, ring this pineapple enol.Has promoting qi circulation and relieving pain, detoxify desinsection
The effect of.It is glutted for food stagnation, depressed pain, ulcer, furunculosis, mange.
Onion effect：Onion alias onion bulb, Onion, onion, round onions, ball green onion.It is nature and flavor temperature, sweet, pungent, Return liver, spleen, lung,
Stomach.Containing volatile oil, rich in allicin, mercaptan, trisulfide etc. and caffeic acid, sinapic acid, cinnamic acid, citrate, polysaccharide and
Several amino acids.Have eliminating the phlegm diuresis, stomach-invigorating intestine-moisturizing, detoxify desinsection the effect of.For losing the appetite, inhibited defecation, dysentery enteritis,
Abdominal pain due to enterositosis, trauma ulcer etc..
Dried orange peel effect：Dried orange peel alias orange peel, expensive old, red skin, yellow orange peel, wide orange peel, PERICARPIUM CITRI RETICULATAE.It is nature and flavor temperature, pungent, bitter, return
Spleen, lung channel.Red tangerine fruit contains volatile oil and hesperidine, Nobiletin, inositol.It is main in volatile oil contain limonene, and contain australene,
Nopinene, β-phellandrene, p-cymene, α-terpinene, linalool and bergamio.Pulp contains citric acid and reduced sugar.Tool
Strengthening the spleen and stomach, during promoting the circulation of qi is wide, the effect of lowering the adverse-rising QI and eliminating phlegm.For the taste stagnation of the circulation of vital energy, gastral cavity abdomen covers with, nausea and vomiting, loses the appetite, cough
Abundant expectoration etc..
Peppermint effect：Peppermint alias wild mint, night breath are fragrant.Nature and flavor are pungent, cool, return lung, Liver Channel.Peppermint ester containing acetic acid, amphene,
Limonene, isomenthone, firpene, piperitenone, resin and a small amount of tannin, Rosmarinic acid；Cauline leaf contains volatile oil, mainly contains in oil
L-menthol, next menthones containing l-.Separately containing isomenthone, pulegone, decyl acetate, menthyl acetate, benzoic acid peppermint
Ester, australene, amyl alcohol-3, nopinene, β-thujene, hexanol -2, d- laurenes, peaceful alkene, octanol -3, Cineole and alpha-terpineol
And a variety of free amino acids such as Soviet Union's ammonia, alanine, glutamic acid, asparagine.Have dispelling wind and heat from the body, head clearing, relieving sore-throat promoting eruption, dredge
The effect of liver promoting the circulation of qi.For affection of exogenous wind-heat, headache, abscess of throat, food stagnation inflatable, aphtha, toothache, sore scabies, urticaria, at the beginning of warm disease
Rise, rubella itch, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.
Eucalyptus leaves effect：Eucalyptus leaves alias Eucalyptus globulus Labill leaf, sheep amomum tsaoko leaf.It is cold in nature, bitter.Return lung, stomach, spleen, Liver Channel.Leaf and flower
Contain volatile oil, its Main Ingredients and Appearance is 1, 8-Cineole, firpene, aromadendrene, cumaldehyde, pinocarveol and 1- acetyl -4- isopropylidenes
Cyclopentene etc..Leaf containing rutin, quercitrin, Quercetin, L (+)-homoserine, also separates eucalyptin again.Bark contains tannin.From
In the tar that the plant obtains, containing guaiacol.Eucalyptus essential oil is one of best bactericide, there is very strong sterilizing power, also simultaneously
Have the function that to reduce internal mucous viscosity, inflammation phenomenon can be relaxed and make mucous membrane comfortable.It is wet available for dysentery, enteritis, mange
Rash, ulcerative carbuncle pyogenic infections etc..
Calamus effect：Calamus also known as smelly calamus, rhizoma calami, mud calamus, great Ye calamus, calamus.For aquatic and herbaceous for many years
Plant.It is warm-natured, acrid flavour, hardship.The thoughts of returning home, stomach.Containing α-, beta-Asarone, cis-Methylisoeugenol, methyl eugenol, calamus alkene two
Alcohol, calamus helicene ketone, acolamone, acorone, the big bull ketone of calamus, acorone, isoacrone etc..Tool a surname's gas, removing toxic substances,
Desinsection, the effect of stomach invigorating.For abdominal distension, enteritis, epizoon etc..
Chinese gall effect：Chinese gall alias Chinese sumac leaf, upper Balls, paint gall nut, red-leaf peach, non-irrigated gall nut, Wu Yanpao.Nature and flavor
It is cold, it is sour, puckery；Return lung, large intestine, kidney channel.Containing Gallotannin, a variety of glucose such as including galloyl-beta-D-glucose.Tool
Astringe the lung, hidroschesis, puckery intestines, controlling nocturnal emission with astringent drugs, hemostasis, the effect of removing toxic substances.It is various for chronic cough of deficiency lung, spontaneous sweating, protracted dysentery chronic diarrhea, prolapse of the anus
Bleeding, carbuncle swells boil.
Alum effect：Alum alias alum, arcanite, potassium aluminium alum, potassium alum；Nature and flavor are sour and astringent, tremble with fear.It is included into lung, spleen, stomach, greatly
Intestines pass through.Alunite is alkaline potassium aluminum sulfate, wherein potassium oxide, aluminum oxide, sulfur trioxide.Have dissolving phlegm, eliminating dampness, antidiarrheal, stop blooding, solution
Poison, the effect of desinsection.For larynx numbness, hepatitis, jaundice, Huang is swollen, taste-blindness rate.
Prescription foundation of the present invention：Chinese herbal medicine contains various bioactivators and natural nutrient substance, can promote fish machine
Body is metabolized and the synthesis of protein and enzyme, anti-inflammation, desinsection benefit body, improves the immunity and anti-stress ability of body, promotes
The growth of fish.Tobacco leaf, onion, dried orange peel have the effect of promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite in side；It is special that onion, dried orange peel, peppermint have
Smell, have food calling, the effect of improving a poor appetite, peppermint also has osmosis；Eucalyptus leaves, calamus, Chinese gall, alum can be antiviral
Property, bacillary, fungoid and parasite type disease；Alum has unique absorption property, can adsorb the impurity to be suspended in water,
And precipitation is formed, make clarification of water, increase oxygen in water, improve water body intensity of photosynthesis, can purify water；And in prescription
Each bulk drug contains certain nutriment in itself, and various amino acid, vitamin, the trace element that such as bulk drug contains can
The nutrition of feed is improved, is improved food conversion ratio；In prescription all medicine phases and, appetite, anti-inflammation, desinsection benefit body can be promoted, carried
High immunity of organisms and resistance against diseases, the growth of accelerating fish.
The Chinese herbal medicine of present invention treatment seawater fish bacterial disease, is the foundation on the basis of a large amount of practical applications have been carried out
Traditional medicine ancient prescription, formed with reference to physiology of fishes and immunologic theoretical screening.Raw material sources used herein are extensive, valency
Lattice are cheap, meanwhile, Chinese herbal medicine production technology very simple of the present invention, it is suitable as dip use.This Chinese herbal medicine is used for seawater
Cultured fishes, growth promoting protection effect is good, and cost is low, easy to use.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment：
Raw material is weighed respectively：Tobacco leaf 160g, onion 180g, dried orange peel 160g, peppermint 120g, eucalyptus leaves 120g, calamus 120g,
Chinese gall 120g, alum 20g.
The preparation method of the Chinese herbal medicine of this treatment marine fish bacterial disease is：Tobacco leaf, onion, old is weighed by weight
Skin, peppermint, eucalyptus leaves, calamus, Chinese gall, alum, and it is respectively crushed into coarse powder；Onion, dried orange peel, eucalyptus leaves, peppermint coarse powder are taken,
The volatile oil distilled out is collected with steam distillation；Tobacco leaf, calamus, Chinese gall, the taste coarse powder of alum four separately are taken, after soaking
It is cooked by slow fire with together with the onion after distillation, dried orange peel, eucalyptus leaves, the peppermint dregs of a decoction；Filtering, obtains first-time filtrate；Take first-time filtrate
The dregs of a decoction afterwards add water decoct it is secondary, respectively obtain secondary filtrate and three times filtrate；Merge filtrate three times, be heated as concentrating
Liquid；Volatile oil is merged with concentrate, by preservative is quantitatively adding, stirred evenly, is filtered, it is filling, sterilizing, produce this treatment fish
The Chinese herbal medicine of class bacterial disease.
1st, double of sliding-tongue sole common bacteria drug sensitive test of Chinese herbal medicine of the present invention
Clinical ill Cynoglossus semilaevis fish is chosen respectively through separating, identifying pathogen as vibrio parahaemolytious, blunt Edward
This Salmonella of Salmonella, common eel, a certain amount of Chinese herbal medicine of the present invention is taken, per mL 1g containing crude drug, sterilized, packing, 4 DEG C save backup.
Medicament sensitivity test：Using plate punch method, by the vibrio parahaemolytious being clinically separated, Vibrio harveyi, common eel
This Salmonella is first inoculated on flat board, in hole add 1g/mL liquid made of herbal prescription of the present invention, with fill it up with without
Overfolw hole is advisable outside.18h is cultivated in 28 DEG C.It is placed in 28 DEG C of constant incubators and cultivates 2h, measures antibacterial circle diameter, and in tradition
Formalin 0.1% compare.Criterion：According to《Pharmacology of Chinese materia medica》With《U.S. clinical Laboratory Standard research institute
The relevant drug sensitive test standardization of version in 2005》Standard, i.e. bacteriostatic diameter >=20mm is extremely quick, 20mm>Bacteriostatic diameter >=15mm
For Gao Min；15mm>Bacteriostatic diameter >=10mm is quick in being, below 10mm is muting sensitive.
Chinese herbal medicine sensitivity tests comparing result of the present invention is shown in Table 1.
The Chinese herbal medicine sensitivity tests comparing result of the present invention of table 1 (24 hours) mm
Table 1 shows that Chinese herbal medicine of the present invention is to vibrio parahaemolytious, Vibrio harveyi, common eel this Salmonella bacteriostatic diameter difference
Up to 18.5,19.0,21.0mm, higher than formaldehyde contrast effect, Chinese herbal medicine of the present invention is to by vibrio parahaemolytious, Vibrio harveyi, eel
Infectious effect caused by this Salmonella of eel is preferable.
Artificial challenge Cynoglossus semilaevis fish Vibrio harveyi morbidity effect clinical trial：180 urosomes grow 20 centimetres 30 grams or so half
Sliding-tongue sole is randomly divided into 6 groups, and every group of 30 tails, packet and processing method are shown in Table 2.
The experiment of table 2 packet and processing method (unit：Tail)
Except healthy control group Cynoglossus semilaevis fish injects sterile saline 0.2mL, remaining each group is equal per tail Cynoglossus semilaevis fish
Inject Vibrio harveyi (3 × 106Individual/mL) 0.2mL.Test fish (except healthy control group) food ration is reduced after attacking malicious 48h, living
Power weakens, and skin engenders small ulcer, bleeding, ascites occurs, and control group does not show above-mentioned symptom.Start by 2 doses of table
Amount administration, the clinical change after observation administration, the daily clinical symptoms and death toll for recording each group fish.Experimental result is shown in Table 3.
Treatment results (the unit of the Experimental infection of table 3：Only, %)
As shown in Table 3, the high, medium and low dosage group of Chinese herbal medicine of the present invention is compared with infection control group, cure rate inequality heteropole
Significantly (P<0.01)；This Chinese herbal medicine height, middle dose group are compared with formalin treatment group, cure rate significant difference (P<0.05)；
The cure rate of low dose group and the not notable (P of formalin treatment group comparing difference>0.05).
2nd, clinical trial after the morbidity of Cynoglossus semilaevis fish natural infection Vibrio harveyi
Natural infection Vibrio harveyi morbidity Cynoglossus semilaevis fish is provided by each raiser in Hebei province Changli County respectively, half sliding-tongue
Sole is grouped, is administered by middle dosage, the equivalent Experimental infection of Symptom Observation.Treatment results are shown in Table 4.
Therapeutic effect (the unit of the natural infection of table 4：Gram, tail, %)
By Cynoglossus semilaevis fish Ureteral Calculus of being fallen ill to natural infection Vibrio harveyi, Chinese herbal treatment group of the present invention is to certainly
So the treatment of infection Vibrio harveyi disease fish has the effect of notable, and average cure rate is 93.6%, typically through 5~7d disease fish rehabilitations,
Recover normal feeding and vigor, and whole process of offeing medicine has no that fish has any adverse reaction.
Claims (2)
1. a kind of Chinese herbal medicine for treating seawater fish bacterial disease, it is characterised in that it is the soup made of the raw material of following weight parts
Agent：Tobacco leaf 4-6 parts, onion 4-6 parts, dried orange peel 3-4 parts, peppermint 3-4 parts, eucalyptus leaves 3-4 parts, calamus 2-4 parts, Chinese gall 2-4 parts,
Alum 0.5-1 parts.
2. the Chinese herbal medicine for the treatment of seawater fish bacterial disease according to claim 1, it is characterised in that it is by following weight
Decoction made of the raw material of part：4 parts of tobacco leaf, 4.5 parts of onion, 4 parts of dried orange peel, 3 parts of peppermint, 3 parts of eucalyptus leaves, 3 parts of calamus, Chinese gall
3 parts, 0.5 part of alum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510200763.5A CN104758555B (en) | 2015-04-24 | 2015-04-24 | Treat the Chinese herbal medicine of seawater fish bacterial disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510200763.5A CN104758555B (en) | 2015-04-24 | 2015-04-24 | Treat the Chinese herbal medicine of seawater fish bacterial disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104758555A CN104758555A (en) | 2015-07-08 |
| CN104758555B true CN104758555B (en) | 2018-02-13 |
Family
ID=53640877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510200763.5A Expired - Fee Related CN104758555B (en) | 2015-04-24 | 2015-04-24 | Treat the Chinese herbal medicine of seawater fish bacterial disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104758555B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327318A (en) * | 2015-11-27 | 2016-02-17 | 青岛海之源智能技术有限公司 | Feed additive for preventing and treating bacterial gill-rot disease of ictalurus punctatus and preparation method of feed additive |
| CN111759950A (en) * | 2019-12-16 | 2020-10-13 | 四川成康动物药业有限公司 | Composite probiotic fermentation product for preventing and treating aquatic vibriosis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102845650A (en) * | 2012-09-28 | 2013-01-02 | 河北科技师范学院 | Chinese herbal medicine feed additive for enhancing growth and preventing diseases of carp |
| CN102934745A (en) * | 2012-09-28 | 2013-02-20 | 河北科技师范学院 | Carp and crucian Chinese herbal phagostimulant and preparation method thereof |
| CN102961660A (en) * | 2012-12-14 | 2013-03-13 | 张�杰 | Chinese herbal medicine for treating fish diseases |
-
2015
- 2015-04-24 CN CN201510200763.5A patent/CN104758555B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102845650A (en) * | 2012-09-28 | 2013-01-02 | 河北科技师范学院 | Chinese herbal medicine feed additive for enhancing growth and preventing diseases of carp |
| CN102934745A (en) * | 2012-09-28 | 2013-02-20 | 河北科技师范学院 | Carp and crucian Chinese herbal phagostimulant and preparation method thereof |
| CN102961660A (en) * | 2012-12-14 | 2013-03-13 | 张�杰 | Chinese herbal medicine for treating fish diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104758555A (en) | 2015-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Meireles et al. | A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: integrative approach on conventional and traditional Asian medicine | |
| CN103141702B (en) | Chinese herb extract feed additive capable of effectively preventing and treating porcine epizootic diarrhea | |
| KR102213743B1 (en) | A process and the composition for increasing immunity-boosting and the growth of animals comprising herbs | |
| CN111374297A (en) | Compound salt and preparation method thereof | |
| KR101930277B1 (en) | Composition for Preventing and Improving Hangover | |
| KR20130104692A (en) | Composition foranti-obesity using extract of crataegi fructus | |
| CN105815611A (en) | Chinese herbal attractant for aquatic animals | |
| CN104758555B (en) | Treat the Chinese herbal medicine of seawater fish bacterial disease | |
| CN104000249B (en) | Hundred malicious fitoncidin drinks and preparation method thereof | |
| KR20130122834A (en) | Korean herb tea composing of extract from spring onion root and method preparing thereof | |
| KR100891914B1 (en) | The method of preparing the functional food for diet using extrative extrated from madicin-matrrials of plants | |
| CN105076728A (en) | Selenium-rich Chinese herbal medicine feed additive and preparation method thereof | |
| KR102115622B1 (en) | Pharmaceutical composition comprising the fermentation extract of medicinal or edible natural products as an effective component for prevention or treatment of thrombosis and health functional food comprising the same | |
| CN1879788A (en) | Virus-clearing capsule | |
| KR20070025584A (en) | It used medicine stuffs alcoholic beverage of manufacturing method | |
| CN105558838A (en) | Multi-flavor black beans and preparation method thereof | |
| CN105981853A (en) | Nutritional function enriched mild warm tea drink recipe | |
| CN108057115A (en) | A kind of composition for treating inflammation of upper respiratory tract infection and preparation method thereof | |
| CN107551140A (en) | It is a kind of to treat cold anaesthetic of kidney deficiency and preparation method thereof | |
| KR102211523B1 (en) | Pills for health foods and methods for manufacturing same | |
| KR101479096B1 (en) | Health functional food comprising extracts of herbal mixture for preventing or improving edema of delivered or pregnant woman | |
| CN113116956A (en) | Traditional Chinese medicine premix and preparation method and application thereof | |
| CN104983845B (en) | Treat the Chinese herbal medicine of seawater fish skin ulcer | |
| RU2637128C1 (en) | Birch extract with medicinal plant decoctions | |
| KR20170029103A (en) | Food composition comprising fermented herb extract for preventing or improving of immunity, dyspepsia, diarrhea and constipation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180213 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |