CN103463224B - Drug for colpitis and preparation method thereof - Google Patents
Drug for colpitis and preparation method thereof Download PDFInfo
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- CN103463224B CN103463224B CN201310431642.2A CN201310431642A CN103463224B CN 103463224 B CN103463224 B CN 103463224B CN 201310431642 A CN201310431642 A CN 201310431642A CN 103463224 B CN103463224 B CN 103463224B
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Abstract
The invention relates to the technical field of a drug for colpitis and a preparation method thereof and specially relates to a drug for colpitis and a preparation method thereof. The drug for colpitis contains the following raw materials in parts by weight: 5-20 parts of coptis chinensis, 5-10 parts of nutgalls, 15-20 parts of liquorices, 5-20 parts of pomegranate barks, 5-20 parts of chamomiles, 10-20 parts of wild alfalfa seeds and 10-20 parts of roses. According to the invention, the drug for the colpitis is prepared through decoction, concentration and high-pressure sterilization. The drug for colpitis has an obvious treatment effect on vaginal infection and mixed infection and has an effective rate of 100% and a cure rate of 91.4%, does not generate drug tolerance, anaphylaxis or toxic or side effects; the healing course of treatment is short, so that a patient can be generally healed within 3 days to 7 days. Moreover, the preparation method of the drug for colpitis disclosed by the invention is environment-friendly and sanitary, has no adverse effects in the body of the patient, and overcomes the defects of the drug tolerance and the anaphylaxis of other drugs.
Description
Technical field
the present invention relates to vaginitis medicine and preparation method thereof technical field, is a kind of vaginitis medicine and preparation method thereof.
Background technology
vaginitis is the common frdquently encountered disease in inflammation of woman genetic system, cardinal symptom is that leukorrhagia increases, pudendal pruritus or scorching hot with pudendum, changes clinically and pruritus vulvae causalgia is Major Clinical feature with the character of leucorrhea, when urethra is involved in infection, the symptom such as dysurea, urgent micturition can be had.Current remedy measures is a lot, but diagnoses and treatment is complicated, and administration time is long, and treatment is slow, and Mean treatment duration is 15 days to 20 days, and average cure rate is about 70%; Must carry out all kinds of chemical examination to these state of an illness diagnosis and treatment, use certain drug again after determining to belong to any infection, in therapeutic process, drug resistance and anaphylaxis cannot be got rid of.
Summary of the invention
the invention provides a kind of vaginitis medicine and preparation method thereof, overcome the deficiency of above-mentioned prior art, it effectively can solve the problem that existing vaginitis diagnoses and treatment is complicated, administration time is long, therapeutic effect is poor and in therapeutic process, drug resistance and anaphylaxis cannot be got rid of.
one of technical scheme of the present invention is realized by following measures: a kind of vaginitis medicine, and raw materials by weight portion contains Rhizoma Coptidis 5 parts to 20 parts, Galla Turcica (Galla Helepensis) 5 parts to 10 parts, 15 parts to 20 parts, Radix Glycyrrhizae, Pericarpium Granati 5 parts to 20 parts, Flos Matricariae chamomillae 5 parts to 20 parts, Herba medicaginis falcatae 10 parts to 20 parts, Flos Rosae Rugosae 10 parts to 20 parts.
here is the further optimization and/or improvements to one of foregoing invention technical scheme:
above-mentioned vaginitis medicine, raw materials by weight portion contains Rhizoma Coptidis 5 parts, Galla Turcica (Galla Helepensis) 10 parts, 15 parts, Radix Glycyrrhizae, Pericarpium Granati 5 parts, Flos Matricariae chamomillae 20 parts, Herba medicaginis falcatae 10 parts, Flos Rosae Rugosae 10 parts.
above-mentioned vaginitis medicine obtains as follows, the first step, the Rhizoma Coptidis of aequum, Galla Turcica (Galla Helepensis), Radix Glycyrrhizae, Pericarpium Granati, Flos Matricariae chamomillae, Herba medicaginis falcatae and Flos Rosae Rugosae is mixed and obtains mixing medical material; Second step, the water adding 1000 parts to 1500 parts in mixing medical material once decocts, and the temperature once decocted is 60 DEG C to 100 DEG C, and the time once decocted is 40 minutes to 90 minutes, filters and obtain a decoction liquor and a filtering residue after once decocting; The water adding 1000 parts to 1500 parts in a filtering residue carries out secondary decoction, and the temperature that secondary decocts is 60 DEG C to 100 DEG C, and the time that secondary decocts is 30 minutes to 80 minutes, filters and obtain secondary decoction liquor and secondary filtering residue after secondary decocts; The water adding 1000 parts to 1500 parts in secondary filtering residue carries out three decoctions, and the temperature decocted for three times is 60 DEG C to 100 DEG C, and the time decocted for three times is 10 minutes to 60 minutes, and after decocting for three times, filtration obtains three decoction liquor and three filtering residues; 3rd step, concentrates after decoction liquor, secondary decoction liquor and three decoction liquor are mixed, and the proportion be concentrated at temperature is 60 DEG C is obtain concentrated solution after 1.1 to 1.3; 4th step, concentrated solution obtains supernatant and is vaginitis medicine after centrifuge.
in a first step above-mentioned, mixing medical material is particle diameter 60 order to 80 object mixing medical material.
above-mentioned in second step, the water soaking 3 first adding 1000 parts to 1500 parts before once decocting in mixing medical material is little of 4 hours, is then once decocted together with soak by the mixing medical material after immersion.
above-mentioned in the 4th step, the rotating speed of centrifuge is 2000 revs/min to 4000 revs/min, centrifugation time be 3 minutes to 20 minutes, obtain supernatant after centrifugal, supernatant obtains vaginitis medicine after autoclaving.
two of technical scheme of the present invention is realized by following measures: a kind of preparation method of vaginitis medicine is carried out in the steps below, the first step, mixes the Rhizoma Coptidis of aequum, Galla Turcica (Galla Helepensis), Radix Glycyrrhizae, Pericarpium Granati, Flos Matricariae chamomillae, Herba medicaginis falcatae and Flos Rosae Rugosae and obtains mixing medical material; Second step, the water adding 1000 parts to 1500 parts in mixing medical material once decocts, and the temperature once decocted is 60 DEG C to 100 DEG C, and the time once decocted is 40 minutes to 90 minutes, filters and obtain a decoction liquor and a filtering residue after once decocting; The water adding 1000 parts to 1500 parts in a filtering residue carries out secondary decoction, and the temperature that secondary decocts is 60 DEG C to 100 DEG C, and the time that secondary decocts is 30 minutes to 80 minutes, filters and obtain secondary decoction liquor and secondary filtering residue after secondary decocts; The water adding 1000 parts to 1500 parts in secondary filtering residue carries out three decoctions, and the temperature decocted for three times is 60 DEG C to 100 DEG C, and the time decocted for three times is 10 minutes to 60 minutes, and after decocting for three times, filtration obtains three decoction liquor and three filtering residues; 3rd step, concentrates after decoction liquor, secondary decoction liquor and three decoction liquor are mixed, and the proportion be concentrated at temperature is 60 DEG C is obtain concentrated solution after 1.1 to 1.3; 4th step, concentrated solution obtains supernatant and is vaginitis medicine after centrifuge.
here is the further optimization and/or improvements to foregoing invention technical scheme two:
in a first step above-mentioned, mixing medical material is particle diameter 60 order to 80 object mixing medical material.
above-mentioned in second step, the water soaking 3 first adding 1000 parts to 1500 parts before once decocting in mixing medical material is little of 4 hours, is then once decocted together with soak by the mixing medical material after immersion.
above-mentioned in the 4th step, the rotating speed of centrifuge is 2000 revs/min to 4000 revs/min, centrifugation time be 3 minutes to 20 minutes, obtain supernatant after centrifugal, supernatant obtains vaginitis medicine after autoclaving.
the present invention by Chinese herbal medicine through decocting, concentrated and autoclaving obtains vaginitis medicine, vaginitis medicine of the present invention infects and mixed infection successful treatment pudendum, and effective percentage reaches 100%, and cure rate is 91.4%; Have no drug resistance, without anaphylaxis and having no side effect, cure short treating period, general patient can cure to 7 days for 3 days; And preparation technology's environmental protection of vaginitis medicine of the present invention, health, have no adverse effects in patient body, compensate for the drug resistance of other drug and hypersensitive deficiency.
Detailed description of the invention
the present invention by the restriction of following embodiment, can not determine concrete embodiment according to technical scheme of the present invention and practical situation.
embodiment 1, this vaginitis medicine, raw materials by weight portion contains Rhizoma Coptidis 5 parts to 20 parts, Galla Turcica (Galla Helepensis) 5 parts to 10 parts, 15 parts to 20 parts, Radix Glycyrrhizae, Pericarpium Granati 5 parts to 20 parts, Flos Matricariae chamomillae 5 parts to 20 parts, Herba medicaginis falcatae 10 parts to 20 parts, Flos Rosae Rugosae 10 parts to 20 parts.
embodiment 2, this vaginitis medicine, raw materials by weight portion contains Rhizoma Coptidis 5 parts or 20 parts, Galla Turcica (Galla Helepensis) 5 parts or 10 parts, 15 parts, Radix Glycyrrhizae or 20 parts, Pericarpium Granati 5 parts or 20 parts, Flos Matricariae chamomillae 5 parts or 20 parts, Herba medicaginis falcatae 10 parts or 20 parts, Flos Rosae Rugosae 10 parts or 20 parts.
embodiment 3, this vaginitis medicine, raw materials by weight portion contains Rhizoma Coptidis 5 parts, Galla Turcica (Galla Helepensis) 10 parts, 15 parts, Radix Glycyrrhizae, Pericarpium Granati 5 parts, Flos Matricariae chamomillae 20 parts, Herba medicaginis falcatae 10 parts, Flos Rosae Rugosae 10 parts.
embodiment 4, this vaginitis medicine is pressed and is stated preparation method and obtain, the first step, the Rhizoma Coptidis of aequum, Galla Turcica (Galla Helepensis), Radix Glycyrrhizae, Pericarpium Granati, Flos Matricariae chamomillae, Herba medicaginis falcatae and Flos Rosae Rugosae is mixed and obtains mixing medical material; Second step, the water adding 1000 parts to 1500 parts in mixing medical material once decocts, and the temperature once decocted is 60 DEG C to 100 DEG C, and the time once decocted is 40 minutes to 90 minutes, filters and obtain a decoction liquor and a filtering residue after once decocting; The water adding 1000 parts to 1500 parts in a filtering residue carries out secondary decoction, and the temperature that secondary decocts is 60 DEG C to 100 DEG C, and the time that secondary decocts is 30 minutes to 80 minutes, filters and obtain secondary decoction liquor and secondary filtering residue after secondary decocts; The water adding 1000 parts to 1500 parts in secondary filtering residue carries out three decoctions, and the temperature decocted for three times is 60 DEG C to 100 DEG C, and the time decocted for three times is 10 minutes to 60 minutes, and after decocting for three times, filtration obtains three decoction liquor and three filtering residues; 3rd step, concentrates after decoction liquor, secondary decoction liquor and three decoction liquor are mixed, and the proportion be concentrated at temperature is 60 DEG C is obtain concentrated solution after 1.1 to 1.3; 4th step, concentrated solution obtains supernatant and is vaginitis medicine after centrifuge.
embodiment 5, this vaginitis medicine is pressed and is stated preparation method and obtain, the first step, the Rhizoma Coptidis of aequum, Galla Turcica (Galla Helepensis), Radix Glycyrrhizae, Pericarpium Granati, Flos Matricariae chamomillae, Herba medicaginis falcatae and Flos Rosae Rugosae is mixed and obtains mixing medical material; Second step, the water adding 1000 parts or 1500 parts in mixing medical material once decocts, and the temperature once decocted is 60 DEG C or 100 DEG C, and the time once decocted is 40 minutes or 90 minutes, filters and obtain a decoction liquor and a filtering residue after once decocting; The water adding 1000 parts or 1500 parts in a filtering residue carries out secondary decoction, and the temperature that secondary decocts is 60 DEG C or 100 DEG C, and the time that secondary decocts is 30 minutes or 80 minutes, filters and obtain secondary decoction liquor and secondary filtering residue after secondary decocts; The water adding 1000 parts or 1500 parts in secondary filtering residue carries out three times and decocts, and the temperature decocted for three times is 60 DEG C or 100 DEG C, and the time decocted for three times is 10 minutes or 60 minutes, filters and obtain three decoction liquor and three filtering residues after decocting for three times; 3rd step, concentrates after decoction liquor, secondary decoction liquor and three decoction liquor are mixed, and the proportion be concentrated at temperature is 60 DEG C is obtain concentrated solution after 1.1 or 1.3; 4th step, concentrated solution obtains supernatant and is vaginitis medicine after centrifuge.
embodiment 6, as the optimization of above-described embodiment, in the first step of embodiment 6, mixing medical material is particle diameter 60 order to 80 object mixing medical material.Pulverizing medicinal materials will be mixed to particle diameter 60 order to 80 object mixing medical material by pulverizer.
embodiment 7, as the optimization of above-described embodiment, in the second step of embodiment 7, the water soaking 3 first adding 1000 parts to 1500 parts before once decocting in mixing medical material is little of 4 hours, is then once decocted together with soak by the mixing medical material after immersion.
embodiment 8, as the optimization of above-described embodiment, in the 4th step of embodiment 8, the rotating speed of centrifuge is 2000 revs/min to 4000 revs/min, centrifugation time be 3 minutes to 20 minutes, obtain supernatant after centrifugal, supernatant obtains vaginitis medicine after autoclaving.
the vaginitis medicine that the above embodiment of the present invention obtains, the Clinical Treatment Test of its application is as follows:
1. treat the antimicrobial drug effect of vaginitis compound recipe
according to the usage and dosage of the vaginitis medicine that the above embodiment of the present invention obtains, consideration vaginitis of the present invention medicine and the medicine group by vaginitis medicine of the present invention being diluted to variable concentrations, intend being determined by antibacterial experiment in vitro.Meanwhile, cure mainly as " for mycete, infusorian and bacterial vaginitis, cervicitis etc. " according to the function of vaginitis medicine of the present invention, intend selecting saccharomyces albicans and staphylococcus aureus as the effects strain.
sample preparation
it is for subsequent use that 1:1,1:2,1:4 and 1:8 dilution by volume of vaginitis medicine the above embodiment of the present invention obtained and water is configured to four concentration dilution liquid.
the preparation of bacterium liquid
be seeded in by saccharomyces albicans in improvement Martin culture medium, cultivate 24h for 25 DEG C, it is for subsequent use that taking-up physiological saline solution is diluted to lx108cfu/ml; Separately be seeded in nutrient broth pipe by staphylococcus glucose coccus, cultivate 24h for 35 DEG C, it is for subsequent use that taking-up physiological saline solution is diluted to lx108cfu/ml.
method
adopt agar solid serial dilution, get aseptic culture dish, add the M-H agar culture medium that 10ml melts respectively, then in the M-H agar culture medium melted, add blank group distilled water and 5ml, 2.5ml, 1.25ml and 0.625ml tetra-concentration dilution liquid of 5ml, 2.5ml, 1.25ml and 0.625ml respectively, then mend to 15ml with the M-H agar culture medium melted respectively, be mixed at normal temperatures.
inoculated bacteria
use micro sample adding appliance dibbling, each vaccination point sample 2ul, improvement Martin culture medium dibbling saccharomyces albicans, staphylococcus glucose coccus dibbling is on nutrient broth medium.
result
the vaginitis medicine that the above embodiment of the present invention obtains is diluted to the average fungistatic effect of four concentration dilution liquid to staphylococcus aureus and saccharomyces albicans and is shown in Table 1:
table 1
| Mushroom | The present invention and distilled water be the diluent that is made into of 1:1 by volume | The present invention and distilled water be the diluent that is made into of 1:2 by volume | The present invention and distilled water be the diluent that is made into of 1:4 by volume | The present invention and distilled water be the diluent that is made into of 1:8 by volume |
| Staphylococcus aureus | - | - | -- + | - ++ |
| Saccharomyces albicans | - | - | - | - |
note :-represent equal asepsis growth in 72h;--+represent be equal asepsis growth in 48h;-++ represent equal asepsis growth in 24h.
as can be seen from Table 1, the vaginitis medicine that the above embodiment of the present invention obtains has obvious bacteriostasis to staphylococcus aureus and saccharomyces albicans.
the observation of curative effect for the treatment of vaginitis compound recipe
2.1 object of study
vaginitis patient 35 example at 19 years old to 50 years old age, average 33.7 years old, the vaginitis medicine adopting the above embodiment of the present invention to obtain was treated, and then carries out own control.
therapeutic Method
all patients all implement the detection of pathogenic microorganism, then vaginitis medicine 10 milliliters to 50 milliliters warm water to the 100 milliliter mixings obtained by the above embodiment of the present invention are configured to the washing liquid that concentration of volume percent is 10% to 50%, scouring pudendum is treated, every day cleans once, clean 3 days to 7 days, the treatment of all patients is all carried out after 3 days to 5 days at clean period and in 3 months, forbids bath in a tub and sexual life.
efficacy determination
within after treatment terminates 1 week, 2 months, 3 months, respectively check once.Check display gynecological inflammation malaise symptoms all disappears, and the smooth recurrence of patient part is normal and occur without congestion and edema and abnormal secretion thing, be then judged to be recovery from illness; Symptom obviously alleviates, and pathogenic germ obviously reduces, and patient part is level and smooth than before, and congested and edema slightly and there is micro-abnormal secretion thing, is judged to take a turn for the better; Alleviating does not appear in disease, and pathogenic germ does not reduce, and patient part relaxes for occurring, still there is serious hyperemia and edema, abnormal secretion thing exists in a large number, then it is invalid to be judged to be.
result
control recovery from illness 32 example in the treatment of this group, average cure rate 91.4%, effective percentage 100%, all has no adverse reaction.
in sum, vaginitis medicine of the present invention infects and mixed infection successful treatment pudendum, and effective percentage reaches 100%, and average cure rate is 91.4%; Have no drug resistance, without anaphylaxis and having no side effect, cure short treating period, general patient can cure to 7 days for 3 days; And preparation technology's environmental protection of vaginitis medicine of the present invention, health, have no adverse effects in patient body, compensate for the drug resistance of other drug and hypersensitive deficiency.
above technical characteristic constitutes embodiments of the invention, and it has stronger adaptability and implementation result, can increase and decrease non-essential technical characteristic according to actual needs, meet the demand of different situations.
Claims (5)
1. a vaginitis medicine, is characterized in that raw materials by weight portion contains Rhizoma Coptidis 5 parts to 20 parts, Galla Turcica (Galla Helepensis) 5 parts to 10 parts, 15 parts to 20 parts, Radix Glycyrrhizae, Pericarpium Granati 5 parts to 20 parts, Flos Matricariae chamomillae 5 parts to 20 parts, Herba medicaginis falcatae 10 parts to 20 parts, Flos Rosae Rugosae 10 parts to 20 parts; Wherein: vaginitis medicine, it is characterized in that obtaining as follows, the first step, the Rhizoma Coptidis of aequum, Galla Turcica (Galla Helepensis), Radix Glycyrrhizae, Pericarpium Granati, Flos Matricariae chamomillae, Herba medicaginis falcatae and Flos Rosae Rugosae are mixed and obtains mixing medical material; Second step, the water adding 1000 parts to 1500 parts in mixing medical material once decocts, and the temperature once decocted is 60 DEG C to 100 DEG C, and the time once decocted is 40 minutes to 90 minutes, filters and obtain a decoction liquor and a filtering residue after once decocting; The water adding 1000 parts to 1500 parts in a filtering residue carries out secondary decoction, and the temperature that secondary decocts is 60 DEG C to 100 DEG C, and the time that secondary decocts is 30 minutes to 80 minutes, filters and obtain secondary decoction liquor and secondary filtering residue after secondary decocts; The water adding 1000 parts to 1500 parts in secondary filtering residue carries out three decoctions, and the temperature decocted for three times is 60 DEG C to 100 DEG C, and the time decocted for three times is 10 minutes to 60 minutes, and after decocting for three times, filtration obtains three decoction liquor and three filtering residues; 3rd step, concentrates after decoction liquor, secondary decoction liquor and three decoction liquor are mixed, and the proportion be concentrated at temperature is 60 DEG C is obtain concentrated solution after 1.1 to 1.3; 4th step, concentrated solution obtains supernatant and is vaginitis medicine after centrifuge; In second step, the water soaking 3 first adding 1000 parts to 1500 parts before once decocting in mixing medical material is little of 4 hours, is then once decocted together with soak by the mixing medical material after immersion; In the 4th step, the rotating speed of centrifuge is 2000 revs/min to 4000 revs/min, centrifugation time be 3 minutes to 20 minutes, obtain supernatant after centrifugal, supernatant obtains vaginitis medicine after autoclaving.
2. vaginitis medicine according to claim 1, is characterized in that raw materials by weight portion contains Rhizoma Coptidis 5 parts, Galla Turcica (Galla Helepensis) 10 parts, 15 parts, Radix Glycyrrhizae, Pericarpium Granati 5 parts, Flos Matricariae chamomillae 20 parts, Herba medicaginis falcatae 10 parts, Flos Rosae Rugosae 10 parts.
3. vaginitis medicine according to claim 1 and 2, is characterized in that in the first step, and mixing medical material is particle diameter 60 order to 80 object mixing medical material.
4. the preparation method of a vaginitis medicine according to claim 1 and 2, it is characterized in that carrying out in the steps below, the first step, mixes the Rhizoma Coptidis of aequum, Galla Turcica (Galla Helepensis), Radix Glycyrrhizae, Pericarpium Granati, Flos Matricariae chamomillae, Herba medicaginis falcatae and Flos Rosae Rugosae and obtains mixing medical material; Second step, the water adding 1000 parts to 1500 parts in mixing medical material once decocts, and the temperature once decocted is 60 DEG C to 100 DEG C, and the time once decocted is 40 minutes to 90 minutes, filters and obtain a decoction liquor and a filtering residue after once decocting; The water adding 1000 parts to 1500 parts in a filtering residue carries out secondary decoction, and the temperature that secondary decocts is 60 DEG C to 100 DEG C, and the time that secondary decocts is 30 minutes to 80 minutes, filters and obtain secondary decoction liquor and secondary filtering residue after secondary decocts; The water adding 1000 parts to 1500 parts in secondary filtering residue carries out three decoctions, and the temperature decocted for three times is 60 DEG C to 100 DEG C, and the time decocted for three times is 10 minutes to 60 minutes, and after decocting for three times, filtration obtains three decoction liquor and three filtering residues; 3rd step, concentrates after decoction liquor, secondary decoction liquor and three decoction liquor are mixed, and the proportion be concentrated at temperature is 60 DEG C is obtain concentrated solution after 1.1 to 1.3; 4th step, concentrated solution obtains supernatant and is vaginitis medicine after centrifuge; Wherein: in second step, the water soaking 3 first adding 1000 parts to 1500 parts before once decocting in mixing medical material is little of 4 hours, is then once decocted together with soak by the mixing medical material after immersion; In the 4th step, the rotating speed of centrifuge is 2000 revs/min to 4000 revs/min, centrifugation time be 3 minutes to 20 minutes, obtain supernatant after centrifugal, supernatant obtains vaginitis medicine after autoclaving.
5. the preparation method of vaginitis medicine according to claim 4, is characterized in that in the first step, and mixing medical material is particle diameter 60 order to 80 object mixing medical material.
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| CN1970068A (en) * | 2006-12-08 | 2007-05-30 | 阿不力克木·买买提明 | Effervescence tablet for treating colpitis, preparation method and use thereof |
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| Title |
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| 维吾尔医药治疗阴道炎;阿提坎等;《中国民族医药杂志》;20121231(第12期);40 * |
| 苜蓿提取物抗炎镇痛作用的实验研究;李兰芳等;《河北医药》;20100430;第32卷(第07期);789-791 * |
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