CN102578169B - Chinese herb biological disinfectant - Google Patents
Chinese herb biological disinfectant Download PDFInfo
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- CN102578169B CN102578169B CN 201210007066 CN201210007066A CN102578169B CN 102578169 B CN102578169 B CN 102578169B CN 201210007066 CN201210007066 CN 201210007066 CN 201210007066 A CN201210007066 A CN 201210007066A CN 102578169 B CN102578169 B CN 102578169B
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Abstract
The invention relates to a Chinese herb biological disinfectant to solve the public nuisance problem of the traditional disinfectant. The Chinese herb biological disinfectant is prepared by adopting the steps of preparing primary liquid medicine by ethanol precipitation of the following bulk drugs in weight ratio: common andrographis herb 40-120, santonin 40-120, celastrus angulatus 35-105, camphor tree 35-105, stephania tetrandra 35-105, rhododendron molle 35-105, macleaya cordata 30-90, pomegranate rind 30-90, clematis root 30-90, radix stemonae 30-90, eucalyptus robusta 30-90, sophora flavescens 30-90, cortex dictamni 25-75, Chinaberry bark and root-bark 25-75, rhizoma corydalis 25-75 and liquorice root 25-75; and adding sodium usnic acid with weight ratio of 0.01-0.03% in the primary liquid medicine, wherein the sodium usnic acid is dissolved with a solvent before the sodium usnic acid is added in the primary liquid medicine. The Chinese herb biological disinfectant contains 0.2% andrographolide, with color being brownish red, PH being 7-8 and density being 1.10g/cm<3>. The Chinese herb biological disinfectant has the advantages of effective disinfection and no harm to human.
Description
Technical field
The present invention relates to a kind of thimerosal, particularly relate to a kind of Chinese herb biological disinfectant.
Background technology
Will contact the pathogeny thing inevitably in the human habitat, but the sterilization method of the most effectively killing the pathogeny thing at present still is the chemical disinfection medicine that use can endanger health of people.Therefore, healthy in order to ensure human body, for not being subjected to the pathogeny thing, to protect mankind infects harm, and a kind of can effectively the sterilization is badly in need of in society, the safe disinfection agent that can not work the mischief to the mankind again.
Summary of the invention
The object of the invention is to overcome the defects of prior art, and providing a kind of can effectively sterilize, the Chinese herb biological disinfectant that the mankind are safe from harm again.
For achieving the above object, the bulk drug of the following weight proportion of the present invention is made original liquid through alcohol precipitation: Herba Andrographitis 40-120, santonin 40-120, Celastrus angulatus 35-105, camphor tree 35-105, powder tetrandra root 35-105, Azalea pontica 35-105, macleaya cordata 30-90, granatum 30-90, root of Chinese clematis 30-90, tuber of stemona 30-90, eucalyptus robusta 30-90, kuh-seng 30-90, root bark of shaggy-fruited dittany 25-75, azedarach 25-75, corydalis tuber 25-75, Radix Glycyrrhizae 25-75;
Original liquid is blended into the usnic acid sodium of 0.01-0.03% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.
Principles of formulating prescriptions monarch drug in a prescription; Herba Andrographitis, santonin.Bitter cold, heat-clearing and damp-drying drug again can purging intense heat and detonicating.This product has the resisting pathogenic microbes effect, to shigella dysenteriae, and Escherichia coli, typhoid bacillus, tubercle bacillus, staphylococcus aureus, hemolytic streptococcus, dermatophyte, the multiple malignant bacteria such as Leptospira all has inhibitory action, ministerial drug; Celastrus angulatus, camphor tree, powder tetrandra root, Azalea pontica.Bitter cold, clearing heat and detoxicating, the merit of cool blood detumescence, the card of the many swollen pestilence heat poison of inhibition helps the golden cypress purging intense heat and detonicating, sterilization.This product extract is to diphtheria bacillus, staphylococcus aureus, and proteus, shigella flexneri again can be to multiple gram-positive bacteria, Gram-negative bacteria, and influenza virus, arboviruse, Si adenositis virus all has inhibitory action.Adjutant; Macleaya cordata, granatum, the root of Chinese clematis, the tuber of stemona, eucalyptus robusta, kuh-seng.Bitter cold cooperates monarch, and ministerial drug is clearing heat and detoxicating, sterilization, desinsection.Separate all medicine poison, pain relieving, pyogenic infections from tumour or sore disappears.Make medicine; The root bark of shaggy-fruited dittany, azedarach, corydalis tuber, Radix Glycyrrhizae.Hardship, sweet, cold.Help monarch, ministerial drug is harmonious, and is clearing heat and detoxicating, sterilization, and insecticidal power strengthens.This product has all medicines in the interaction energy mediation side of supplementary drug, makes monarch, minister, and assistant makes the ingredients prescription common, heat-clearing and damp-drying drug, purging intense heat and detonicating.Strengthen sterilization, insecticidal power, the effect of anti-Amoeba comprehensively.
Wherein: Herba Andrographitis is herb or the leaf of acanthaceous plant Herba Andrographitis.
Santonin is the dry capitulum of various Asian product artemisia (Artemisia) plant or is the toxic medicament of producing the dry capitulum extraction of artemisia (Artemisia) plant from various Asian, i.e. a kind of terpene.Molecular formula C14H16O3.When using extract, carry out corresponding decrement by the amount of taking of bulk drug flower.
Celastrus angulatus, plant latin name: Celastrus angulatus Maxim, plant another name: horse is heartbroken, the complete stool of bitter bark, tiger fiber crops.
Camphor tree is tree root, tree bar, the branch of camphor tree.
The powder tetrandra root is the root of menispermaceae phytobezoar toad Stephania tetrandra S.Moore.
Azalea pontica is the flower of ericad Chinese azalea Rhododendron molle G.Don.
Macleaya cordata formal name used at school: Macleaya cordata (Willd.) R.Br. English name: Plumepoppy section name: Papaveraceae Papaveraceae generic name: Macleaya.
Granatum is the pericarp of Punicaceae plant pomegranate.
The root of Chinese clematis is the dry root and rhizome of dicotyledon Ranunculaceae Ranunculaceae root of Chinese clematis Clematis chinensisOsbeck, Clematis hexapetala (mountain knotweed) C.hexapetala Pall. or northeast clematis (black common vetch) C.manshuricaRupr..
The tuber of stemona is the dried root of Stemonaceae plant radix stemonae sessilifoliae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (B1.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..
Eucalyptus robusta, formal name used at school: Eucalyptus robusta Smith; Another name: the leaf of oily markon, You Jiali, eucalyptus, An Shu, the young tree of mosquito.
Kuh-seng (formal name used at school: the plant that Sophora flavescens) belongs to for the pulse family kuh-seng.
The root bark of shaggy-fruited dittany is the root skin of Rutaceae herbaceos perennial shaggy-fruited dittany and Dictamnus angustifolius.
Dry bark and the root skin of azedarach Meliaceae plant melia toosendan.
Corydalis tuber is the stem tuber of papaveraceae plant corydalis.
Through evidence: can be to typhoid bacillus, Escherichia coli, tubercle bacillus, shigella dysenteriae, staphylococcus aureus.Comma bacillus, Mycobacterium leprae, Candida albicans and dermatophyte, Leptospira, gram-positive bacteria, Gram-negative bacteria, the diseases such as pruitus all have inhibitory action.
Can be used for hospital; The wound sterilization, sterilization before the injection, pre-operation sterilization, Medical treatment device is guarded against sterilization, sterilization in the aircraft passenger compartment, sterilization in the passenger car, sterilization in the bus, sterilization in the taxi, sterilization in the swimming pool, sterilization in the public place, sterilization in the restaurant, table ware in the family, cleans the sterilizations such as vegetables.Extension rate during use; 9 times.Have and effectively to sterilize, the advantage that the mankind are safe from harm again.
As optimization, Herba Andrographitis 80, santonin 80, Celastrus angulatus 70, camphor tree 70, powder tetrandra root 70, Azalea pontica 70, macleaya cordata 60, granatum 60, the root of Chinese clematis 60, the tuber of stemona 60, eucalyptus robusta 60, kuh-seng 60, the root bark of shaggy-fruited dittany 50, azedarach 50, corydalis tuber 50, Radix Glycyrrhizae 50;
Original liquid is blended into the usnic acid sodium of 0.02% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.
As optimization, described usnic acid sodium is used first the dissolved in purified water of 1.5-3 times of weight.
As optimization, described alcohol precipitation is that concentrated intermediate carried out alcohol precipitation after described bulk drug was decocted.
As optimization, first described bulk drug is infiltrated before the described decoction, described decocting time is 1-1.5 hour, adds the water of 1.5-2 times of weight during described the decoction, the described alcohol precipitation time is 48 hours.Described alcohol precipitation preferably uses 75% alcohol.
As optimization, first described bulk drug is carried out the rinsing impurity elimination before the described infiltration.
As optimization, before described infiltration or rinsing impurity elimination, first described bulk drug is pulverized.
As optimization, described camphor tree is tree root or tree bar or branch or camphor or the camphorated oil of camphor tree, can take the corresponding decrement adapted of content of camphor or camphorated oil when using camphor or camphorated oil in eucalyptus root or tree bar or the branch.
As optimization, described finished product: content 0.2% creat lactone, color are brownish red, PH7-8, density 1.10g/cm3.
Through evidence: can be to typhoid bacillus, Escherichia coli, tubercle bacillus, shigella dysenteriae, staphylococcus aureus.Comma bacillus, Mycobacterium leprae, Candida albicans and dermatophyte, Leptospira, gram-positive bacteria, Gram-negative bacteria, the diseases such as pruitus all have inhibitory action.Can be used for hospital; The wound sterilization, sterilization before the injection, pre-operation sterilization, Medical treatment device is guarded against sterilization, sterilization in the aircraft passenger compartment, sterilization in the passenger car, sterilization in the bus, sterilization in the taxi, sterilization in the swimming pool, sterilization in the public place, sterilization in the restaurant, table ware in the family, cleans the sterilizations such as vegetables.Extension rate; 9 times.
After adopting technique scheme, Chinese herb biological disinfectant of the present invention has and can effectively sterilize, the advantage that the mankind are safe from harm again.
Embodiment one, and Chinese herb biological disinfectant of the present invention is that the bulk drug of following weight proportion is made original liquid through alcohol precipitation: Herba Andrographitis 40KG, santonin 40KG, Celastrus angulatus 35KG, camphor tree 35KG, powder tetrandra root 35KG, Azalea pontica 35KG, macleaya cordata 30KG, granatum 30KG, root of Chinese clematis 30KG, tuber of stemona 30KG, eucalyptus robusta 30KG, kuh-seng 30KG, root bark of shaggy-fruited dittany 25KG, azedarach 25KG, corydalis tuber 25KG, Radix Glycyrrhizae 25KG;
Original liquid is blended into the usnic acid sodium of 0.01% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.Usnic acid sodium is preferably used first the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoction-concentrate-alcohol precipitation-Recycled ethanol-storage-use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrated, alcohol precipitation reclaims; By technological requirement the purity of ethanol is reclaimed, after holding temperature and making original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium is used first the pure water of 2 times of weight, is blended into original liquid after the dissolving and makes finished product.The containers store of packing into.
The preferred 1-1.5 of described decoction hour, add the water of 1.5-2 times of weight during described decoct, described alcohol precipitation is preferably 48 hours.Described alcohol precipitation preferably uses 75% alcohol.Described camphor tree is tree root or tree bar or branch or camphor or the camphorated oil of camphor tree, can take the corresponding decrement adapted of content of camphor or camphorated oil when using camphor or camphorated oil in eucalyptus root or tree bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, PH7-8, density 1.10g/cm
3
Embodiment two, and Chinese herb biological disinfectant of the present invention is that the bulk drug of following weight proportion is made original liquid through alcohol precipitation: Herba Andrographitis 120KG, santonin 120KG, Celastrus angulatus 105KG, camphor tree 105KG, powder tetrandra root 105KG, Azalea pontica 105KG, macleaya cordata 90KG, granatum 90KG, root of Chinese clematis 90KG, tuber of stemona 90KG, eucalyptus robusta 90KG, kuh-seng 90KG, root bark of shaggy-fruited dittany 75KG, azedarach 75KG, corydalis tuber 75KG, Radix Glycyrrhizae 75KG;
Original liquid is blended into the usnic acid sodium of 0.03% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.Usnic acid sodium is preferably used first the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoctions-concentrate-alcohol precipitation-Recycled ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrated, alcohol precipitation reclaims; By technological requirement the purity of ethanol is reclaimed, after holding temperature and making original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium is used first the pure water of 2 times of weight, is blended into original liquid after the dissolving and makes finished product.The containers store of packing into.
The preferred 1-1.5 of described decoction hour, add the water of 1.5-2 times of weight during described decoct, described alcohol precipitation is preferably 48 hours.Described alcohol precipitation preferably uses 75% alcohol.Described camphor tree is tree root or tree bar or branch or camphor or the camphorated oil of camphor tree, can take the corresponding decrement adapted of content of camphor or camphorated oil when using camphor or camphorated oil in eucalyptus root or tree bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, PH7-8, density 1.10g/cm
3
Embodiment three, and Chinese herb biological disinfectant of the present invention is that the bulk drug of following weight proportion is made original liquid through alcohol precipitation: Herba Andrographitis 40KG, santonin 120KG, Celastrus angulatus 35KG, camphor tree 105KG, powder tetrandra root 35KG, Azalea pontica 105KG, macleaya cordata 30KG, granatum 90KG, root of Chinese clematis 30KG, tuber of stemona 90KG, eucalyptus robusta 30KG, kuh-seng 90KG, root bark of shaggy-fruited dittany 25KG, azedarach 75KG, corydalis tuber 25KG, Radix Glycyrrhizae 75KG;
Original liquid is blended into the usnic acid sodium of 0.03% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.Usnic acid sodium is preferably used first the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoctions-concentrate-alcohol precipitation-Recycled ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrated, alcohol precipitation reclaims; By technological requirement the purity of ethanol is reclaimed, after holding temperature and making original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium is used first the pure water of 2 times of weight, is blended into original liquid after the dissolving and makes finished product.The containers store of packing into.
The preferred 1-1.5 of described decoction hour, add the water of 1.5-2 times of weight during described decoct, described alcohol precipitation is preferably 48 hours.Described alcohol precipitation preferably uses 75% alcohol.Described camphor tree is tree root or tree bar or branch or camphor or the camphorated oil of camphor tree, can take the corresponding decrement adapted of content of camphor or camphorated oil when using camphor or camphorated oil in eucalyptus root or tree bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, PH7-8, density 1.10g/cm
3
Embodiment four, and Chinese herb biological disinfectant of the present invention is that the bulk drug of following weight proportion is made original liquid through alcohol precipitation: Herba Andrographitis 120KG, santonin 40KG, Celastrus angulatus 105KG, camphor tree 35KG, powder tetrandra root 105KG, Azalea pontica 35KG, macleaya cordata 90KG, granatum 30KG, root of Chinese clematis 90KG, tuber of stemona 30KG, eucalyptus robusta 90KG, kuh-seng 30KG, root bark of shaggy-fruited dittany 75KG, azedarach 25KG, corydalis tuber 75KG, Radix Glycyrrhizae 25KG;
Original liquid is blended into the usnic acid sodium of 0.01% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.Usnic acid sodium is preferably used first the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoctions-concentrate-alcohol precipitation-Recycled ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrated, alcohol precipitation reclaims; By technological requirement the purity of ethanol is reclaimed, after holding temperature and making original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium is used first the pure water of 2 times of weight, is blended into original liquid after the dissolving and makes finished product.The containers store of packing into.
The preferred 1-1.5 of described decoction hour, add the water of 1.5-2 times of weight during described decoct, described alcohol precipitation is preferably 48 hours.Described alcohol precipitation preferably uses 75% alcohol.Described camphor tree is tree root or tree bar or branch or camphor or the camphorated oil of camphor tree, can take the corresponding decrement adapted of content of camphor or camphorated oil when using camphor or camphorated oil in eucalyptus root or tree bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, PH7-8, density 1.10g/cm
3
Embodiment five, and Chinese herb biological disinfectant of the present invention is that the bulk drug of following weight proportion is made original liquid through alcohol precipitation: Herba Andrographitis 40KG, santonin 80KG, Celastrus angulatus 105KG, camphor tree 35KG, powder tetrandra root 70KG, Azalea pontica 105KG, macleaya cordata 30KG, granatum 60KG, root of Chinese clematis 90KG, tuber of stemona 30KG, eucalyptus robusta 60KG, kuh-seng 90KG, root bark of shaggy-fruited dittany 25KG, azedarach 50KG, corydalis tuber 75KG, Radix Glycyrrhizae 25KG;
Original liquid is blended into the usnic acid sodium of 0.03% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.Usnic acid sodium is preferably used first the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoction-concentrate-alcohol precipitation-Recycled ethanol-storage-use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrated, alcohol precipitation reclaims; By technological requirement the purity of ethanol is reclaimed, after holding temperature and making original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium is used first the pure water of 2 times of weight, is blended into original liquid after the dissolving and makes finished product.The containers store of packing into.
The preferred 1-1.5 of described decoction hour, add the water of 1.5-2 times of weight during described decoct, described alcohol precipitation is preferably 48 hours.Described alcohol precipitation preferably uses 75% alcohol.Described camphor tree is tree root or tree bar or branch or camphor or the camphorated oil of camphor tree, can take the corresponding decrement adapted of content of camphor or camphorated oil when using camphor or camphorated oil in eucalyptus root or tree bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, PH7-8, density 1.10g/cm
3
Embodiment six, and the bulk drug that biological antiseptic liquid of the present invention is following weight proportion is made original liquid through alcohol precipitation: Herba Andrographitis 80, santonin 80, Celastrus angulatus 70, camphor tree 70, powder tetrandra root 70, Azalea pontica 70, macleaya cordata 60, granatum 60, the root of Chinese clematis 60, the tuber of stemona 60, eucalyptus robusta 60, kuh-seng 60, the root bark of shaggy-fruited dittany 50, azedarach 50, corydalis tuber 50, Radix Glycyrrhizae 50;
Original liquid is blended into the usnic acid sodium of 0.02% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.Usnic acid sodium is preferably used first the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoctions-concentrate-alcohol precipitation-Recycled ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrated, alcohol precipitation reclaims; By technological requirement the purity of ethanol is reclaimed, after holding temperature and making original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium is used first the pure water of 2 times of weight, is blended into original liquid after the dissolving and makes finished product.The containers store of packing into.
The preferred 1-1.5 of described decoction hour, add the water of 1.5-2 times of weight during described decoct, described alcohol precipitation is preferably 48 hours.Described alcohol precipitation preferably uses 75% alcohol.Described camphor tree is tree root or tree bar or branch or camphor or the camphorated oil of camphor tree, can take the corresponding decrement adapted of content of camphor or camphorated oil when using camphor or camphorated oil in eucalyptus root or tree bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, PH7-8, density 1.10g/cm
a
Through evidence: can be to typhoid bacillus, Escherichia coli, tubercle bacillus, shigella dysenteriae, staphylococcus aureus.Comma bacillus, Mycobacterium leprae, Candida albicans and dermatophyte, Leptospira, gram-positive bacteria, Gram-negative bacteria, the diseases such as pruitus all have inhibitory action.Can be used for hospital; The wound sterilization, sterilization before the injection, pre-operation sterilization, Medical treatment device is guarded against sterilization, sterilization in the aircraft passenger compartment, sterilization in the passenger car, sterilization in the bus, sterilization in the taxi, sterilization in the swimming pool, sterilization in the public place, sterilization in the restaurant, table ware in the family, cleans the sterilizations such as vegetables.Extension rate; 9 times.Now exemplify part test as follows:
Bacteriostasis test one:
1, material: the liquid that 1) medicine: embodiment of the invention 1-6 makes, convert 9 times of water, hereinafter to be referred as three invention liquids; 2) clean that is cloudy.
2, bacterial classification: staphylococcus aureus; Typhoid bacillus; Paratyphoid bacillus A; Bacillus paratyphosus B; Shigella shigae; Shigella flexneri; Alpha streptococcus; Beta streptococcus; Escherichia coli; Proteus; Wax sample bacillus anthracis; Pseudomonas aeruginosa; White is read coccus.
3, medium: be nutrient broth and 10% calf serum meat soup.
4, method: adopt the in vitro liquid dilution method (doubling dilution) in the in-vitro antibacterial experimental method.Medicine of the present invention is all got 6 in the test tube that 13 * 100mm sterilization has tampon to the neutralize bacteriostatic test of each bacterial strain of above-mentioned 13 kinds of bacterial strains, add aseptic broth bouillon 2.0ml in every Guan Zhongxian, then put into the liquid 2.0ml of the present invention that the 1st pipe adds sterilization, take out behind the mixing 2.0ml put into the 2nd pipe, the like, discard until the 4th pipe takes out 2.0ml, the liquid diluted concentration was respectively 1: 16,1: 32,1: 64,1: 128.The 5th pipe does not add medicine in contrast, whether is suitable for bacterial growth in order to observe medium, only adds medicine 2.0ml of the present invention in the 6th pipe, and mixing takes out 2.0ml and discards, and does not add bacterium, has pollution-free through just observing medicine of the present invention.To cultivate with meat soup 8 hours experimental bacteria liquid, be diluted to 10-3 concentration with aseptic meat soup, and get 0.1ml and add respectively in the above-mentioned 1-5 pipe, and put into together 37 ℃ of incubators behind the mixing and cultivate 24 hours observed results.
5, result:
Medicine dilution factor of the present invention
Medicine dilution factor of the present invention
Medicine dilution factor of the present invention
Fungistatic effect between embodiment 4-6 and the embodiment 1-3 does not have the significance difference, lists therefore omit.
Simple medicine of the present invention places 37 ℃ of incubators to cultivate 24 hours without bacterial growth, illustrates through the medicine of the present invention of sterilization not contaminated; 13 simple bacterial strain pipes place 37 ℃ of incubators to cultivate had the bacterium raised growth in 24 hours, illustrated that the used aseptic broth bouillon of this test is suitable for bacterial growth; And in 13 kinds of bacterial strain pipes, add respectively the medicine of the present invention of variable concentrations, and cultivated 24 hours through placing 37 ℃ of incubators, all show bacteriostasis in various degree.Illustrate that medicine of the present invention all has bacteriostasis to described 13 kinds of bacteriums.Clean you cloudy all have in various degree bacteriostasis to 13 kinds of bacteriums, but compare with medicine of the present invention, except staphylococcus aureus all not as the bacteriostasis of medicine of the present invention.
Bacteriostasis test two:
1, experiment material: aseptic ordinary nutrient agar medium, (9CM) flat device, suction pipe, sheep blood, magnificent test tube etc.;
2, the liquid made of the above-mentioned 1-6 embodiment of medicine of the present invention is converted 9 times of water, calls medicine of the present invention, the peaceful biological fluids of Kang Shi woman in the following text, clean you are cloudy, Clean Living is pure, FUYINJIE, the cloudy washing lotion of Ri Shuan, Shu Er, Chinese magic liquid.
3, test strain: staphylococcus aureus; Staphylococcus epidermidis; Alpha streptococcus; Beta streptococcus; Hay bacillus; Bacillus coli communis; Enteropathogenic E．Coli 0119; Paratyphoid bacillus A; Pseudomonas aeruginosa; Diphtheroid; Bacillus perfringens.
4, test method-paper disk method: 1), with Xinhua consider paper, bore dia is 0.5CM garden shape scraps of paper autoclaving; 2), required bacterium is evenly coated according to the bacterial strain different choice filled in the plate of different culture media.3), adsorb required different types of thimerosal with the worry scraps of paper and be affixed on the plate, and do blank (NS) with physiological saline.4) observed result after cultivating in, 37 ℃, 24 hours.5), with ruler measurement inhibition zone diameter size and record the result.
5, result of the test: seven kinds of disinfectant bacteriostatic tests of medicine embodiment six of the present invention and other relatively
Medicine embodiment 1-5 of the present invention and embodiment 6 list therefore omit without significantly difference.
By carrying out the comparison of antibacterial aspect to the medicinal different classes of bacterial strain of the present invention and with other seven kinds of daily thimerosals, the result shows: medical instrument of the present invention has pair gram-positive bacteria, Gram-negative bacteria (totally 11 kinds) stronger bacteriostasis to be arranged, and certain sterilizing ability is arranged.Also prove simultaneously: the fungistatic effect between the embodiment 1-6 does not have the significance difference.
6, white is read the bacteriostatic test (paper is levied method) of coccus
Experimental technique: 1) read coccus with the even cloth white of plate that contains the husky medium of 10% calf serum.2), FUYINJIE pure medicine of the present invention and other seven kinds of thimerosal: Ri Shuan, clean your the moon, the cloudy washing lotion of Shu Er, the peaceful biological fluids of Kang Shi woman, Clean Living, Chinese magic liquid.Dilute in proportion, sterile working is got the aseptic worry scraps of paper and is drawn required solution, is affixed in the plate.3), stroke-physiological saline solution is done blank (NS).4) put 37 ℃, 24 hours, cultivated in 48 hours.5), the result shows: by carrying out the comparison of antibacterial aspect to the medicinal different classes of bacterial strain of the present invention and with other seven kinds of daily thimerosals, the result shows: medical instrument of the present invention has pair white to read coccus stronger bacteriostasis is arranged, and certain sterilizing ability is arranged.Also prove simultaneously: the fungistatic effect between the embodiment 1-6 does not have the significance difference.
Acute skin irritation test:
Test method: GB7919-87, contamination approach: through skin.Experimental animal: the large white healthy adult rabbit of ear of Japan.Sex quantity: public 2, female 2.Weight range: 3.0 ± 0.5 kilograms.
The liquid that cardinal symptom: embodiment 5 makes is converted 9 times of water, call medicine of the present invention in the following text, applied ointment or plaster 24 hours, remove tested material, observed at 1 hour, have an animal local skin erythema to occur, other animal local skin is without unusual variation, erythema disappears after 24 hours, and all animal skins and normal control are in full accord.Reacting integral mean value skin irritatin in 1,24,48 hour is 0.08 minute.Embodiment 1-4 and 6 and the effect of embodiment 5 without remarkable difference, therefore omit narration.
Conclusion: according to the skin irritatin grade scale, prove that medicine of the present invention is to the skin nonirritant.
Medicine clinical practice of the present invention is summed up:
One, clinical data
1, Drug utilization index: all patient's readme leucorrhea increasings, the bean dregs sample that is white in color, pruritus vulvae, cusalgia, painful unusual person, gynecologial examination vulva, vagina mucosa hyperemia, and with white membranoid substance.
2, administrated method: the patient converts 10 milliliters in 9 times of water (calling medicine of the present invention in the following text) with the present embodiment 1-6 invention medicine and cleans vulva, and vagina every day 1-2 time, 7-10 days is a course for the treatment of.
3, criterion of therapeutical effect: transference cure after the medication, the normal person of leukorrhea routine test is for curing.The sx↓ person is for taking a turn for the better after the medication; Symptom does not disappear, and leukorrhea is chemically examined unusual person for invalid.
Two treatment results:
1, symptom changes: see Table 1:
2, result for the treatment of sees Table 2
| Curative effect | The example number | Percentage (%) |
| Recovery from illness | 28 | 93.33％ |
| Take a turn for the better | 3 | 6.66％ |
| Invalid | 0 | 0 |
| Amount to | 30 | 100％ |
Treat colpomycosis by observing 30 examples with medicine of the present invention, 93.33%6 more; 6.669/0 take a turn for the better, efficient 100%, we think that this medication effect is good, welcome by the patient.Can become one of our the most frequently used women's good medicine.
Example 1 week so-and-so; 60 years old.Married, main suit's pruritus vulvae is scorching hot, pain, leukorrhea are many: peaceful under the sitting and lying during severe symptoms, with frequent micturition, odynuria is half a year.Both: toward diabetes, coronary heart disease and cataract medical history are arranged: once go to too much home's hospitalize.Obviously the effect rolling is not treated, and after with medicine embodiment one treatment of the present invention three times, the readme miracle has occurred, and can sleep well, and has used continuously again 6-7 days, and all malaise symptoms all disappear, and free from slight illness, and are very grateful.
Example 2 Lee xx, 31 years old, married, readme itching of vulva, leukorrhea were many, be the bean dregs sample, all have an attack of one's old illness annual summer, and not only oneself violated disease summer in this year, its husband's genitalia severity of scratching where it itches, two people are simultaneously with medicine embodiment two treatments of the present invention, two people's symptoms disappear very soon, and the toposcopy inflammation disappears, and pay a return visit and cure rear not recurrence.
3 xx of example, 24 years old, married, the readme itching of vulva, leukorrhea is many, and peculiar smell is arranged, frequent micturition, odynuria, intercourse pain, must scratch wiping regardless of occasion, place when serious, oneself feel very painful and shy, use medicine embodiment three of the present invention to treat transference cure after a course for the treatment of, and face showed the smile.
4 xx of example are 29 years old, married.Readme itching of vulva pain, leukorrhea is many especially, is the bean dregs sample, through treating several days symptom transference cures with medicine embodiment four of the present invention.Return visit is learnt, rear not recurrence.
Example 5 Hao xx, 19 years old unmarried.Yan Shu is after going Bei Dai River swimming, and vulva is very itched; Carry and increase.Peculiar smell is arranged, blue with medicine embodiment five treatment 6-7 of the present invention without, malaise symptoms disappears, carry transfer to normal.
Example 6 is contained xx, 10 years old, unmarried.Readme this time in the period used others two sanitary napkins after, vulva is very itched, menostaxis 3 days, color is unusual, and leucorrhea increasing after menstruation is clean is the bean dregs sample: painful unusual: as to be ashamed of again hospital treatment, after treating a course for the treatment of with medicine embodiment six of the present invention, gone a worry.
Example 7 Jin xx are 26 years old, married.Readme is itching of vulva after swimming, and leucorrhea increasing is white in color, and peculiar smell is arranged, and simultaneously with frequent micturition, odynuria, once specially controls the diagnosis and treatment of gynaecological disease clinic at individuality.Result for the treatment of is not obvious, and after with medicine embodiment one treatment of the present invention, effect is splendid: symptom disappears very soon, and return visit is learnt, not recurrence after the self-healing.
Example 8 ginger xx are 25 years old, married.The readme pruritus vulvae.Cusalgia, intercourse pain, leukorrhea are many especially, are the bean dregs sample, and peculiar smell is arranged.The husband does not understand, own agony, and after with medicine embodiment two treatments of the present invention, transference cure.The man and wife gets togather as before.
Example 9 blue so-and-so, 38 years old, married.The readme itching of vulva, leukorrhea is many, is from the color lump shape, with frequent micturition, odynuria, intercourse pain also has the symptoms such as hemorrhage, once treats a few days effect not remarkable, through with two courses for the treatment of of medicine embodiment three treatments of the present invention, miracle has occurred, transference cure, and the postcoital bleeding phenomenon has not had yet.
Example, 10 king xx are 28 years old, married.The readme itching of vulva, leukorrhea is many, and bulk is white in color: with intercourse pain and bleeding is arranged, menstruation is inaccurate, often in advance or after the mistake, once repeatedly treatment was violated during fashion, and oneself is afraid of not only but also worried, through with transference cure after medicine embodiment of the present invention four treatments two courses for the treatment of, also do not have an attack of one's old illness in many days, menstruation is also normal, can remove slight illness and the worried happiness of oneself for this medicine.
Example 11 Liu xx are 30 years old, married.Yan Shu very itches since the rear vulva of going out.Leucorrhea increasing, bulk is white in color; There is tunica albuginea to come off when washing, with frequent micturition, urgent urination, odynuria, makes and oneself feel restless, can not be quiet sleeping, be in extreme agony, through treating a course for the treatment of with medicine embodiment four of the present invention, symptom disappears entirely.
12 xx of example are 32 years old, married.Readme has been used once behind the sanitary napkin that small shop buys, and vulva is very itched incomparably, and leucorrhea increasing with frequent micturition, odynuria, through with 2-3 days transference cures of medicine embodiment five treatments of the present invention, continues use a course for the treatment of, recurs after more.
Example 13 old xx are 30 years old, married.Readme itching of vulva pain, leucorrhea increasing is the bean dregs sample, and symptom disappears very soon after treating with medicine embodiment six of the present invention.
Example 14 cutter xx are 26 years old, married.Readme itching of vulva pain, leucorrhea increasing disappears very soon with the rear symptom of medicine embodiment one treatment of the present invention.
Example 15 is in xx, and is 29 years old, married.Readme pruritus vulvae 2-3 days, leucorrhea increasing: symptom rapidly disappears after treating with medicine embodiment two of the present invention.
Example xx 16 Wei is 27 years old, married.The readme vulva is scratched pain, is very itched, leucorrhea increasing, and white with the vulva cusalgia, is liked blowing, and the impact sleep is through using 31 courses for the treatment of of medicine embodiment of the present invention; Transference cure.
Example 17 grandson xx are 27 years old, married.Readme pregnant May, itching of vulva, leucorrhea increasing.Be the bean dregs sample more. frowziness, be afraid of that medication is unfavorable to fetus, therefore not treatment, recently sx↑ is itched and bitterly is impatient at, through using 41 courses for the treatment of of medicine embodiment of the present invention, transference cure, for fear of infecting fetus, suggestion is local to last till pregnant August with medicine treatment of the present invention.1
Example 18 grandson xx are 25 years old, married.Frequent micturition, urgent urination, odynuria, itching of vulva after the readme swimming, leucorrhea increasing arrives first the internal medicine diagnosis and treatment, frequent micturition, urgent urination, odynuria transference cure, but vulva still itches, leukorrhea is without minimizing, and through with after medicine embodiment five treatments of the present invention courses for the treatment of, symptom all disappears.
Example 19 Lee xx, 30 years old, itching of vulva pain behind the sauna bath, one week of leucorrhea increasing were washed in readme.Produce effects not after oneself is washed with the liquid medicine bought, after with medicine embodiment six treatments of the present invention, symptom disappears very soon.
Example 20 Zhao xx, 33 years old, married, the readme itching of vulva, leucorrhea increasing, the bulk that is white in color, with frequent micturition, urgent urination, odynuria, after with medicine embodiment one treatment of the present invention, symptom disappears very soon.
Example 21 old xx are 29 years old, married, that readme itching of vulva, their early stage leukorrhea are is yellow, amount is many, peculiar smell is arranged, and does not take notice of, the rear sx↑ of going swimming, vulva is very itched, and leukorrhea is more increased, and is mixed with white like the bean dregs sample, after treating a course for the treatment of with medicine embodiment three of the present invention, sx↓ continues with after the course for the treatment of transference cure.
Example 22 king xx, 40 years old; Married, readme pruritus vulvae, cusalgia, leucorrhea increasing half a year, feel restless when serious, can not fall asleep, only scratch and grab or firmly wipe raft with cloth and could remove except the discomfort of itching: but burning heat sensation is felt in the part subsequently, pain, skin is frayed very soon to fester, through several hospital therapies, unsatisfactory curative effect, by using 42 course of therapy of medicine embodiment of the present invention, symptom obviously alleviates, and local ulcer heals substantially, at present just at continual cure.
Example 23 is worn xx, and 49 years old, married, the readme external genital was scratchy, burn and pain, leucorrhea increasing, and the curdled milk that is white in color bulk, through with the medicine embodiment transference cure course for the treatment of on May Day of the present invention, return visit is learnt, so far recurrence.
Example 24 model xx, woman, 32 years old are married. the readme vulva is very itched, and burning heat sensation is arranged, leucorrhea increasing, the bean dregs sample that is white in color has peculiar smell, does not feel any better through symptomatic treatment.Rear with medicine embodiment of the present invention six treatments after 10 days malaise symptoms disappear, it is three normal that leukorrhea transfers to, follows up a case by regular visits to and have no recurrence.
Example 25 relies xx, and the woman is 32. years old, married.Readme is this time gone on business to south: because having used public bathtub, cause private parts very to be itched, leucorrhea increasing is the bean dregs sample, peculiar smell is arranged. through the diagnosis and treatment of suiting the medicine to the illness, do not feel any better, painful unusual, come my institute's diagnosis and treatment, after treating a course for the treatment of with medicine embodiment one of the present invention, above transference cure is paid a return visit and is had no recurrence.，
Example 26 poplar xx, the woman, 25 years old, married, the readme external genital was itched bitterly, and leucorrhea increasing has peculiar smell.Medicine embodiment two of the present invention treats a course for the treatment of through usefulness, above transference cure, and leukorrhea also transfers to normally.
Example 27xx, the woman is 32 years old, married.Say that stating external genital itches bitterly, leucorrhea increasing is the white peas or beans slag specimen, and unusual stink is arranged, and is very painful, and rear usefulness medicine embodiment three of the present invention treats a course for the treatment of, and above malaise symptoms all disappears.
Example 28 Jin xx, the woman, 44 years old, married: readme over nearly more than ten days external genital scratch ancient term for country school; Vaginal fluid increases, and is white in color! Personal PP powder and salt solution clean external genital and have no positive effect, and symptom day by day increases the weight of, and through with after medicine embodiment four treatments of the present invention courses for the treatment of, above malaise symptoms all disappears.
Example 29 money xx, the woman is 44 years old, married.Readme begins private parts at swimming pool swimming second day itches, and adularescent look secretion, clean and one week of oral anti-inflammatory drug thing with the PP powder voluntarily, and DeGrain, through with after one course for the treatment of of medicine embodiment five treatments of the present invention, the private parts disappearance of scratching where it itches, leukorrhea is also normal.
Example 30 grandson xx, the woman, 20 years old, unmarried, readme in the last few days unknown cause caused that external genital itches, and with pain, leucorrhea increasing has peculiar smell, cleans external genital with light salt brine voluntarily, and poor effect is with after one course for the treatment of of medicine embodiment six treatments of the present invention.Above-mentioned symptom disappears, and patient is very delight.
Claims (9)
1. a Chinese herb biological disinfectant is characterized in that the bulk drug of following weight proportion is made original liquid through alcohol precipitation: Herba Andrographitis 40-120, santonin 40-120, Celastrus angulatus 35-105, camphor tree 35-105, powder tetrandra root 35-105, Azalea pontica 35-105, macleaya cordata 30-90, granatum 30-90, root of Chinese clematis 30-90, tuber of stemona 30-90, eucalyptus robusta 30-90, kuh-seng 30-90, root bark of shaggy-fruited dittany 25-75, azedarach 25-75, corydalis tuber 25-75, Radix Glycyrrhizae 25-75;
Original liquid is blended into the usnic acid sodium of 0.01-0.03% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.
2. described thimerosal according to claim 1 is characterized in that Herba Andrographitis 80, santonin 80, Celastrus angulatus 70, camphor tree 70, powder tetrandra root 70, Azalea pontica 70, macleaya cordata 60, granatum 60, the root of Chinese clematis 60, the tuber of stemona 60, eucalyptus robusta 60, kuh-seng 60, the root bark of shaggy-fruited dittany 50, azedarach 50, corydalis tuber 50, Radix Glycyrrhizae 50;
Original liquid is blended into the usnic acid sodium of 0.02% weight ratio, and usnic acid sodium is used first dissolution with solvents, is blended in the original liquid and makes.
3. according to claim 1 or 2 described thimerosals, it is characterized in that described usnic acid sodium uses first the dissolved in purified water of 1.5-3 times of weight.
4. according to claim 1 or 2 described thimerosals, it is characterized in that described alcohol precipitation is that concentrated intermediate carried out alcohol precipitation after described bulk drug was decocted.
5. described thimerosal according to claim 4, it is characterized in that first described bulk drug being infiltrated before the described decoction, described decocting time is 1-1.5 hour, adds the water of 1.5-2 times of weight during described the decoction, the described alcohol precipitation time is 48 hours, and described alcohol precipitation uses 75% alcohol.
6. described thimerosal according to claim 5 is characterized in that first described bulk drug being carried out the rinsing impurity elimination before the described infiltration.
7. described thimerosal according to claim 6 is characterized in that first described bulk drug being pulverized before described rinsing impurity elimination.
8. according to claim 1 or 2 described thimerosals, it is characterized in that described camphor tree is tree root or tree bar or the branch of camphor tree.
9. according to claim 1 or 2 described thimerosals, it is characterized in that the finished product that described bulk drug is made: content 0.2% creat lactone, color are brownish red, pH7-8, density 1.10g/cm
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| CN102772722A (en) * | 2012-07-31 | 2012-11-14 | 陆利勇 | Traditional Chinese medicine decoction for treating scabies |
| CN103392749B (en) * | 2013-08-19 | 2015-11-25 | 王子乐 | A kind of Traditional Chinese medicine disinfectant for operating room sterilization of instruments and preparation method |
| CN104208357B (en) * | 2014-01-24 | 2018-04-24 | 徐兴利 | Wound sprays Chinese herbal antibacterial liquid |
| CN103800628B (en) * | 2014-03-18 | 2015-12-09 | 王文珠 | A kind of medicament for sterilizing before anesthesia surgery |
| CN104383570A (en) * | 2014-11-26 | 2015-03-04 | 南京正宽医药科技有限公司 | Mixed disinfection type medical equipment disinfection cabinet |
| CN105497602A (en) * | 2014-11-30 | 2016-04-20 | 陈海明 | Traditional Chinese medicine for treating fixed drug eruption |
| CN104645175A (en) * | 2015-03-13 | 2015-05-27 | 龚灿锋 | Traditional Chinese medicine disinfection liquid for clinical laboratory |
| CN104770417A (en) * | 2015-04-16 | 2015-07-15 | 刘晶 | Chinese medicinal disinfectant and preparation method thereof |
| CN106259531A (en) * | 2016-08-03 | 2017-01-04 | 覃燕兰 | A kind of Toys Disinfection liquid |
| CN106259546A (en) * | 2016-08-03 | 2017-01-04 | 覃燕兰 | A kind of Toys Disinfection liquid |
| CN108156881A (en) * | 2018-01-17 | 2018-06-15 | 安徽省华禾种业有限公司 | A kind of method for improving violet cabbage percentage of seedgermination |
| CN107996067A (en) * | 2018-01-17 | 2018-05-08 | 安徽省华禾种业有限公司 | A kind of method for improving seed of bitter gourd germination percentage |
| CN113491740B (en) * | 2020-04-01 | 2022-05-27 | 生物源生物技术（深圳）股份有限公司 | Composition for preventing and treating candida albicans disease and medicine and feed additive containing same |
| CN113197214B (en) * | 2021-04-26 | 2022-04-26 | 江苏省中国科学院植物研究所 | Application of tetrandrine as agricultural bactericide |
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