CN102578169A - Chinese herb biological disinfectant - Google Patents

Chinese herb biological disinfectant Download PDF

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CN102578169A
CN102578169A CN2012100070664A CN201210007066A CN102578169A CN 102578169 A CN102578169 A CN 102578169A CN 2012100070664 A CN2012100070664 A CN 2012100070664A CN 201210007066 A CN201210007066 A CN 201210007066A CN 102578169 A CN102578169 A CN 102578169A
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root
medicine
usnic acid
camphor
acid sodium
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CN102578169B (en
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蔡葵荣
张彦斌
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Abstract

The invention relates to a Chinese herb biological disinfectant to solve the public nuisance problem of the traditional disinfectant. The Chinese herb biological disinfectant is prepared by adopting the steps of preparing primary liquid medicine by ethanol precipitation of the following bulk drugs in weight ratio: common andrographis herb 40-120, santonin 40-120, celastrus angulatus 35-105, camphor tree 35-105, stephania tetrandra 35-105, rhododendron molle 35-105, macleaya cordata 30-90, pomegranate rind 30-90, clematis root 30-90, radix stemonae 30-90, eucalyptus robusta 30-90, sophora flavescens 30-90, cortex dictamni 25-75, Chinaberry bark and root-bark 25-75, rhizoma corydalis 25-75 and liquorice root 25-75; and adding sodium usnic acid with weight ratio of 0.01-0.03% in the primary liquid medicine, wherein the sodium usnic acid is dissolved with a solvent before the sodium usnic acid is added in the primary liquid medicine. The Chinese herb biological disinfectant contains 0.2% andrographolide, with color being brownish red, ph being 7-8 and density being 1.10g/cm<3>. The Chinese herb biological disinfectant has the advantages of effective disinfection and no harm to human.

Description

Chinese herbal medicine biological antiseptic liquid
Technical field
The present invention relates to a kind of thimerosal, particularly relate to a kind of Chinese herbal medicine biological antiseptic liquid.
Background technology
Will contact the pathogeny thing inevitably in the human habitat, but the sterilization method of the most effectively killing the pathogeny thing at present is to use still meeting to endanger the chemical disinfection medicine of health of people.Therefore, healthy in order to ensure human body, do not receive the pathogeny thing to infect harm in order to protect the mankind, a kind of can effectively the sterilization is badly in need of in society, the safe disinfection agent that can not work the mischief to the mankind again.
Summary of the invention
The object of the invention is to overcome the above-mentioned defective of prior art, and providing a kind of can effectively sterilize, the Chinese herbal medicine biological antiseptic liquid that the mankind are safe from harm again.
For realizing above-mentioned purpose, the following materials of weight proportions medicine of the present invention is processed original liquid through alcohol precipitation: Herba Andrographitis 40-120, santonin 40-120, Celastrus angulatus 35-105, camphor tree 35-105, Fourstamen Stephania Root 35-105, Azalea pontica 35-105, macleaya cordata 30-90, granatum 30-90, root of Chinese clematis 30-90, tuber of stemona 30-90, Da Ye press 30-90, kuh-seng 30-90, root bark of shaggy-fruited dittany 25-75, azedarach 25-75, corydalis tuber 25-75, Radix Glycyrrhizae 25-75;
Original liquid is blended into the usnic acid sodium of 0.01-0.03% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.
Principles of formulating prescriptions monarch drug in a prescription; Herba Andrographitis, santonin.Bitter cold, heat-clearing and damp-drying drug again can purging intense heat and detonicating.These article have the resisting pathogenic microbes effect, to shigella dysenteriae, and Escherichia coli, typhoid bacillus, tubercle bacillus, staphylococcus aureus, hemolytic streptococcus, dermatophyte, multiple malignant bacteria such as Leptospira all has inhibitory action, ministerial drug; Celastrus angulatus, camphor tree, Fourstamen Stephania Root, Azalea pontica.Bitter cold, clearing heat and detoxicating, the merit of cool blood detumescence, the card of the many swollen pestilence heat poison of inhibition helps the golden cypress purging intense heat and detonicating, sterilization.This product extract diphtheria bacillus, Staphylococcus aureus, Proteus, Shigella flexneri but also on a variety of Gram-positive bacteria, Gram-negative bacteria, and influenza virus, arboviruses, Si mumps virus are inhibition.Adjutant; Macleaya cordata, granatum, the root of Chinese clematis, the tuber of stemona, Da Ye presses, kuh-seng.Bitter cold cooperates monarch, and ministerial drug is clearing heat and detoxicating, sterilization, desinsection.Separate all medicine poison, pain relieving, pyogenic infections from tumour or sore disappears.Make medicine; The root bark of shaggy-fruited dittany, azedarach, corydalis tuber, Radix Glycyrrhizae.Hardship, sweet, cold.Help monarch, ministerial drug is harmonious, and is clearing heat and detoxicating, sterilization, and insecticidal power strengthens.These article have the effect of supplementary drug. all medicines in can mediation side, make monarch, and minister, assistant, it is common to make medicine form prescription, heat-clearing and damp-drying drug, purging intense heat and detonicating.Strengthen sterilization, insecticidal power, the effect of anti-Amoeba comprehensively.
Wherein: Herba Andrographitis is the herb or the leaf of acanthaceous plant Herba Andrographitis.
Santonin is the dry capitulum of multiple Asia product artemisia (Artemisia) plant or is the toxic medicament of producing the dry capitulum extraction of artemisia (Artemisia) plant from multiple Asia, promptly a kind of terpene.Molecular formula C14H16O3.When using extract, carry out corresponding decrement by the amount of taking of bulk drug flower.
Celastrus angulatus, plant latin name: Celastrus angulatus Maxim, plant another name: horse is heartbroken, the complete stool of bitter bark, tiger fiber crops.
Camphor tree is tree root, tree bar, the branch of camphor tree.
Fourstamen Stephania Root is the root of menispermaceous plants stone toad Stephania tetrandra S.Moore.
Azalea pontica is the flower of ericad Chinese azalea Rhododendron molle G.Don.
Macleaya cordata formal name used at school: Macleaya cordata (Willd.) R.Br. English name: Plumepoppy section name: Papaveraceae Papaveraceae generic name: Macleaya.
Granatum is the pericarp of Punicaceae plant pomegranate.
The root of Chinese clematis is the dry root and rhizome of dicotyledon Ranunculaceae Ranunculaceae root of Chinese clematis Clematis chinensisOsbeck, Clematis hexapetala (mountain knotweed) C.hexapetala Pall. or northeast clematis (black common vetch) C.manshuricaRupr..
The tuber of stemona is the dried root of Stemonaceae plant radix stemonae sessilifoliae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..
Da Ye presses, formal name used at school: Eucalyptus robusta Smith; Another name: the leaf of oily markon, You Jiali, eucalyptus, An Shu, the young tree of mosquito.
Kuh-seng (formal name used at school: the plant that Sophora flavescens) belongs to for the pulse family kuh-seng.
The root bark of shaggy-fruited dittany is the root skin of Rutaceae herbaceos perennial shaggy-fruited dittany and narrow leaf shaggy-fruited dittany.
The dry bark and the root skin of azedarach Meliaceae plant melia toosendan.
Corydalis tuber is the stem tuber of papaveraceae plant corydalis.
Through evidence: can be to typhoid bacillus, Escherichia coli, tubercle bacillus, shigella dysenteriae, staphylococcus aureus.Comma bacillus, Mycobacterium leprae, Candida albicans and dermatophyte, Leptospira, gram-positive bacteria, Gram-negative bacteria, diseases such as pruitus all have inhibitory action.
Can be used for hospital; The wound sterilization, sterilization before the injection, sterilization before the operation, medical device is guarded against sterilization, sterilization in the aircraft passenger compartment; Sterilization in the passenger car, sterilization in the bus, sterilization in the taxi, sterilization in the swimming pool, sterilization in the public place; Sterilization in the restaurant, table ware in the family, cleans sterilizations such as vegetables.Extension rate during use; 9 times.Have and effectively to sterilize, the advantage that the mankind are safe from harm again.
As optimization, Herba Andrographitis 80, santonin 80, Celastrus angulatus 70, camphor tree 70, Fourstamen Stephania Root 70, Azalea pontica 70, macleaya cordata 60, granatum 60, the root of Chinese clematis 60, the tuber of stemona 60, Da Ye by 60, kuh-seng 60, the root bark of shaggy-fruited dittany 50, azedarach 50, corydalis tuber 50, Radix Glycyrrhizae 50;
Original liquid is blended into the usnic acid sodium of 0.02% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.
As optimization, the first dissolved in purified water of said usnic acid sodium with the 1.5-3 times of weight.
As optimization, said alcohol precipitation is said bulk drug to be decocted the concentrated intermediate in back carry out alcohol precipitation.
As optimization, earlier said bulk drug is soaked into before the said decoction, said decocting time is 1-1.5 hour, adds the water of 1.5-2 times of weight during said the decoction, the said alcohol precipitation time is 48 hours.Said alcohol precipitation preferably uses 75% alcohol.
As optimization, earlier said bulk drug is carried out the rinsing impurity elimination before the said infiltration.
As optimization, before said infiltration or rinsing impurity elimination, earlier said bulk drug is pulverized.
As optimization, said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.
As optimization, said finished product: content 0.2% creat lactone, color are brownish red, ph7-8, density 1.10g/cm 3
Through evidence: can be to typhoid bacillus, Escherichia coli, tubercle bacillus, shigella dysenteriae, staphylococcus aureus.Comma bacillus, Mycobacterium leprae, Candida albicans and dermatophyte, Leptospira, gram-positive bacteria, Gram-negative bacteria, diseases such as pruitus all have inhibitory action.Can be used for hospital; The wound sterilization, sterilization before the injection, sterilization before the operation, medical device is guarded against sterilization, sterilization in the aircraft passenger compartment; Sterilization in the passenger car, sterilization in the bus, sterilization in the taxi, sterilization in the swimming pool, sterilization in the public place; Sterilization in the restaurant, table ware in the family, cleans sterilizations such as vegetables.Extension rate; 9 times.
After adopting technique scheme, Chinese herbal medicine biological antiseptic liquid of the present invention has and can effectively sterilize, the advantage that the mankind are safe from harm again.
Embodiment
Embodiment one, and Chinese herbal medicine biological antiseptic liquid of the present invention is that following materials of weight proportions medicine is processed original liquid through alcohol precipitation: Herba Andrographitis 40KG, santonin 40KG, Celastrus angulatus 35KG, camphor tree 35KG, Fourstamen Stephania Root 35KG, Azalea pontica 35KG, macleaya cordata 30KG, granatum 30KG, root of Chinese clematis 30KG, tuber of stemona 30KG, Da Ye press 30KG, kuh-seng 30KG, root bark of shaggy-fruited dittany 25KG, azedarach 25KG, corydalis tuber 25KG, Radix Glycyrrhizae 25KG;
Original liquid is blended into the usnic acid sodium of 0.01% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.The preferred elder generation of usnic acid sodium is with the dissolved in purified water of 1.5-3 times of weight.
The preparation method: get-feed intake [by the recipe quantity] of Chinese medicinal herbs------invade profit-decoction-concentrated-alcohol precipitation-recovery ethanol-storage--and use in removal of impurities [main soil is assorted] by rinsing.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrate, alcohol precipitation reclaims; Reclaim the purity of ethanol by technological requirement, after holding temperature and processing original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium with the pure water of 2 times of weight, is blended into original liquid and processes finished product earlier after the dissolving.The containers store of packing into.
The preferred 1-1.5 of said decoction hour, add the water of 1.5-2 times of weight during said decoct, said alcohol precipitation is preferably 48 hours.Said alcohol precipitation preferably uses 75% alcohol.Said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, ph7-8, density 1.10g/cm 3
Embodiment two, and Chinese herbal medicine biological antiseptic liquid of the present invention is that following materials of weight proportions medicine is processed original liquid through alcohol precipitation: Herba Andrographitis 120KG, santonin 120KG, Celastrus angulatus 105KG, camphor tree 105KG, Fourstamen Stephania Root 105KG, Azalea pontica 105KG, macleaya cordata 90KG, granatum 90KG, root of Chinese clematis 90KG, tuber of stemona 90KG, Da Ye press 90KG, kuh-seng 90KG, root bark of shaggy-fruited dittany 75KG, azedarach 75KG, corydalis tuber 75KG, Radix Glycyrrhizae 75KG;
Original liquid is blended into the usnic acid sodium of 0.03% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.The preferred elder generation of usnic acid sodium is with the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoctions-concentrated-alcohol precipitation-recovery ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrate, alcohol precipitation reclaims; Reclaim the purity of ethanol by technological requirement, after holding temperature and processing original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium with the pure water of 2 times of weight, is blended into original liquid and processes finished product earlier after the dissolving.The containers store of packing into.
The preferred 1-1.5 of said decoction hour, add the water of 1.5-2 times of weight during said decoct, said alcohol precipitation is preferably 48 hours.Said alcohol precipitation preferably uses 75% alcohol.Said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, ph7-8, density 1.10g/cm 3
Embodiment three, and Chinese herbal medicine biological antiseptic liquid of the present invention is that following materials of weight proportions medicine is processed original liquid through alcohol precipitation: Herba Andrographitis 40KG, santonin 120KG, Celastrus angulatus 35KG, camphor tree 105KG, Fourstamen Stephania Root 35KG, Azalea pontica 105KG, macleaya cordata 30KG, granatum 90KG, root of Chinese clematis 30KG, tuber of stemona 90KG, Da Ye press 30KG, kuh-seng 90KG, root bark of shaggy-fruited dittany 25KG, azedarach 75KG, corydalis tuber 25KG, Radix Glycyrrhizae 75KG;
Original liquid is blended into the usnic acid sodium of 0.03% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.The preferred elder generation of usnic acid sodium is with the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]-rinsing-invade profit-decoctions-concentrated-alcohol precipitation-recovery ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrate, alcohol precipitation reclaims; Reclaim the purity of ethanol by technological requirement, after holding temperature and processing original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium with the pure water of 2 times of weight, is blended into original liquid and processes finished product earlier after the dissolving.The containers store of packing into.
The preferred 1-1.5 of said decoction hour, add the water of 1.5-2 times of weight during said decoct, said alcohol precipitation is preferably 48 hours.Said alcohol precipitation preferably uses 75% alcohol.Said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, ph7-8, density 1.10g/Gm 3
Embodiment four, and Chinese herbal medicine biological antiseptic liquid of the present invention is that following materials of weight proportions medicine is processed original liquid through alcohol precipitation: Herba Andrographitis 120KG, santonin 40KG, Celastrus angulatus 105KG, camphor tree 35KG, Fourstamen Stephania Root 105KG, Azalea pontica 35KG, macleaya cordata 90KG, granatum 30KG, root of Chinese clematis 90KG, tuber of stemona 30KG, Da Ye press 90KG, kuh-seng 30KG, root bark of shaggy-fruited dittany 75KG, azedarach 25KG, corydalis tuber 75KG, Radix Glycyrrhizae 25KG;
Original liquid is blended into the usnic acid sodium of 0.01% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.The preferred elder generation of usnic acid sodium is with the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]-rinsing-invade profit-decoctions-concentrated-alcohol precipitation-recovery ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrate, alcohol precipitation reclaims; Reclaim the purity of ethanol by technological requirement, after holding temperature and processing original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium with the pure water of 2 times of weight, is blended into original liquid and processes finished product earlier after the dissolving.The containers store of packing into.
The preferred 1-1.5 of said decoction hour, add the water of 1.5-2 times of weight during said decoct, said alcohol precipitation is preferably 48 hours.Said alcohol precipitation preferably uses 75% alcohol.Said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, ph7-8, density 1.10g/cm 3
Embodiment five, and Chinese herbal medicine biological antiseptic liquid of the present invention is that following materials of weight proportions medicine is processed original liquid through alcohol precipitation: Herba Andrographitis 40KG, santonin 80KG, Celastrus angulatus 105KG, camphor tree 35KG, Fourstamen Stephania Root 70KG, Azalea pontica 105KG, macleaya cordata 30KG, granatum 60KG, root of Chinese clematis 90KG, tuber of stemona 30KG, Da Ye press 60KG, kuh-seng 90KG, root bark of shaggy-fruited dittany 25KG, azedarach 50KG, corydalis tuber 75KG, Radix Glycyrrhizae 25KG;
Original liquid is blended into the usnic acid sodium of 0.03% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.The preferred elder generation of usnic acid sodium is with the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoctions-concentrated-alcohol precipitation-recovery ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrate, alcohol precipitation reclaims; Reclaim the purity of ethanol by technological requirement, after holding temperature and processing original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium with the pure water of 2 times of weight, is blended into original liquid and processes finished product earlier after the dissolving.The containers store of packing into.
The preferred 1-1.5 of said decoction hour, add the water of 1.5-2 times of weight during said decoct, said alcohol precipitation is preferably 48 hours.Said alcohol precipitation preferably uses 75% alcohol.Said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, ph7-8, density 1.10g/cm 3
Embodiment six, and biological antiseptic liquid of the present invention is that following materials of weight proportions medicine is processed original liquid through alcohol precipitation: Herba Andrographitis 80, santonin 80, Celastrus angulatus 70, camphor tree 70, Fourstamen Stephania Root 70, Azalea pontica 70, macleaya cordata 60, granatum 60, the root of Chinese clematis 60, the tuber of stemona 60, Da Ye by 60, kuh-seng 60, the root bark of shaggy-fruited dittany 50, azedarach 50, corydalis tuber 50, Radix Glycyrrhizae 50;
Original liquid is blended into the usnic acid sodium of 0.02% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.The preferred elder generation of usnic acid sodium is with the dissolved in purified water of 1.5-3 times of weight.
Preparation method: the getting-feed intake of Chinese medicinal herbs [by recipe quantity]--removal of impurities [main soil is assorted]--rinsing-invade profit-decoctions-concentrated-alcohol precipitation-recovery ethanol-storage--use.
More specifically be: traditional Chinese medicine (after the precomminution) take by weighing by proportioning.Add water rinse (adding the water that does not have bulk drug), the soil of removing in the medicinal material is assorted.Add water infiltration (adding the water that does not have bulk drug), decoct [extraction]; Concentrate, alcohol precipitation reclaims; Reclaim the purity of ethanol by technological requirement, after holding temperature and processing original liquid, be blended into the usnic acid sodium of 0.02% weight ratio, be blended into method: usnic acid sodium with the pure water of 2 times of weight, is blended into original liquid and processes finished product earlier after the dissolving.The containers store of packing into.
The preferred 1-1.5 of said decoction hour, add the water of 1.5-2 times of weight during said decoct, said alcohol precipitation is preferably 48 hours.Said alcohol precipitation preferably uses 75% alcohol.Said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.Product is preferred: content 0.2%g/ml creat lactone, color are brownish red, ph7-8, density 1.10g/cm 3
Through evidence: can be to typhoid bacillus, Escherichia coli, tubercle bacillus, shigella dysenteriae, staphylococcus aureus.Comma bacillus, Mycobacterium leprae, Candida albicans and dermatophyte, Leptospira, gram-positive bacteria, Gram-negative bacteria, diseases such as pruitus all have inhibitory action.Can be used for hospital; The wound sterilization, sterilization before the injection, sterilization before the operation, medical device is guarded against sterilization, sterilization in the aircraft passenger compartment; Sterilization in the passenger car, sterilization in the bus, sterilization in the taxi, sterilization in the swimming pool, sterilization in the public place; Sterilization in the restaurant, table ware in the family, cleans sterilizations such as vegetables.Extension rate; 9 times.The part test of at present giving an example is following:
Bacteriostasis test one:
1, material: the soup that 1) medicine: embodiment of the invention 1-6 processes, convert 9 times of water, hereinafter to be referred as three invention soups; 2) clean that is cloudy.
2, bacterial classification: staphylococcus aureus; Typhoid bacillus; Paratyphoid bacillus A; Bacillus paratyphosus B; Shigella shigae; Shigella flexneri; Alpha streptococcus; Beta streptococcus; Escherichia coli; Proteus; Wax appearance bacillus anthracis; Pseudomonas aeruginosa; Candida albicans.
3, medium: be nutrient broth and 10% calf serum meat soup.
4, method: adopt the dilution method of soup in vitro (doubling dilution) in the in-vitro antibacterial experimental method.Medicine of the present invention is all got 6 in the test tube that 13 * 100mm sterilization has tampon to the bacteriostatic test of above-mentioned each bacterial strain of 13 kinds of bacterial strains neutralization; Add aseptic broth bouillon 2.0ml in every Guan Zhongxian; Put into the soup 2.0ml of the present invention that the 1st pipe adds sterilization then; Take out behind the mixing 2.0ml put into the 2nd pipe, and the like, take out 2.0ml up to the 4th pipe and discard, the soup diluted concentration was respectively 1: 16,1: 32,1: 64,1: 128.The 5th pipe does not add medicine as contrast, whether is suitable for bacterial growth so that observe medium, only adds medicine 2.0ml of the present invention in the 6th pipe, and mixing takes out 2.0ml and discards, and does not add bacterium, has pollution-free through just observing medicine of the present invention.To cultivate 8 hours experimental bacteria liquid with meat soup, be diluted to 10 with aseptic meat soup -3Concentration is got 0.1ml and is added respectively in the above-mentioned 1-5 pipe, puts into 37 ℃ of incubators behind the mixing together and cultivates 24 h observation results.
5, result:
Medicine dilution factor of the present invention
Medicine dilution factor of the present invention
Figure BSA00000655759800082
Medicine dilution factor of the present invention
Figure BSA00000655759800083
Fungistatic effect between embodiment 4-6 and the embodiment 1-3 does not have the significance difference, and list the Therefore, omited.
Figure BSA00000655759800084
Figure BSA00000655759800091
Simple medicine of the present invention places 37 ℃ of incubators to cultivate 24 hours no bacterial growths, explains through the medicine of the present invention of sterilization not contaminated; 13 simple bacterial strain pipes place 37 ℃ of incubators to cultivate had the bacterium raised growth in 24 hours, explained that the used aseptic broth bouillon of this test is suitable for bacterial growth; And in 13 kinds of bacterial strain pipes, add the medicine of the present invention of variable concentrations respectively, and cultivated 24 hours through placing 37 ℃ of incubators, all show bacteriostasis in various degree.Explain that medicine of the present invention all has bacteriostasis to said 13 kinds of bacteriums.Clean you cloudy all have bacteriostasis in various degree to 13 kinds of bacteriums, but compare with medicine of the present invention, except that staphylococcus aureus all not as the bacteriostasis of medicine of the present invention.
Bacteriostasis test two:
1, experiment material: aseptic ordinary nutrient agar medium, (9CM) flat device, suction pipe, sheep blood, magnificent test tube etc.;
2, the soup processed of the above-mentioned 1-6 embodiment of medicine of the present invention is converted 9 times of water, calls medicine of the present invention, the peaceful biological fluids of Kang Shi woman in the following text, clean you are cloudy, Clean Living is pure, FUYINJIE, Ri Shuan, the cloudy washing lotion of Shu Er, Chinese magic liquid.
3, test strain: staphylococcus aureus; MRSE; Alpha streptococcus; Beta streptococcus; Hay bacillus; Bacillus coli communis; Enteropathogenic E 0119; Paratyphoid bacillus A; Pseudomonas aeruginosa; Diphtheroid; Bacillus perfringens.
4, test method-paper disk method: 1), use Xinhua to consider paper, bore dia is 0.5CM garden shape scraps of paper autoclaving; 2), required bacterium is evenly coated according to the bacterial strain different choice filled in the plate of different medium.3), adsorb required different types of thimerosal with the worry scraps of paper and be affixed on the plate, and do blank (NS) with physiological saline.4) cultivated the back observed result in, 37 ℃, 24 hours.5), with ruler measurement inhibition zone diameter size and write down the result.
5, result of the test: seven kinds of disinfectant bacteriostatic tests of medicine embodiment six of the present invention and other relatively
Figure BSA00000655759800092
Medicine embodiment 1-5 of the present invention and embodiment 6 do not have significantly difference, and list the Therefore, omited.
Through carrying out the comparison of antibacterial aspect to the medicinal different classes of bacterial strain of the present invention and with other seven kinds of daily thimerosals; The result shows: medical instrument of the present invention has pair gram-positive bacteria, Gram-negative bacteria (totally 11 kinds) stronger bacteriostasis to be arranged, and certain sterilizing ability is arranged.Also prove simultaneously: the fungistatic effect between the embodiment 1-6 does not have the significance difference.
6, to the bacteriostatic test (paper is levied method) of Candida albicans
Experimental technique: 1) with the even cloth Candida albicans of plate that contains the husky medium of 10% calf serum.2), FUYINJIE pure, Chinese magic liquid medicine of the present invention and other seven kinds of thimerosal: Ri Shuan, clean your the moon, the cloudy washing lotion of Shu Er, the peaceful biological fluids of Kang Shi woman, Clean Living.Dilute in proportion, sterile working is got the aseptic worry scraps of paper and is drawn required solution, is affixed in the plate.3), SPSS is done blank (NS).4) put 37 ℃, 24 hours, cultivated in 48 hours.5), the result shows: through carrying out the comparison of antibacterial aspect to the medicinal different classes of bacterial strain of the present invention and with other seven kinds of daily thimerosals, the result shows: medical instrument of the present invention has pair Candida albicans that stronger bacteriostasis is arranged, and certain sterilizing ability is arranged.Also prove simultaneously: the fungistatic effect between the embodiment 1-6 does not have the significance difference.
Acute skin irritation test:
Test method: GB7919-87, contamination approach: through skin.Experimental animal: the big white healthy adult rabbit of ear of Japan.Sex quantity: public 2, female 2.Weight range: 3.0 ± 0.5 kilograms.
The soup that cardinal symptom: embodiment 5 processes is converted 9 times of water, calls medicine of the present invention in the following text, applies ointment or plaster 24 hours; Removal is tried thing; In 1 h observation, there is an animal local skin erythema to occur, the no abnormal variation of other animal local skin; Erythema disappears after 24 hours, and all animal skins and normal control are in full accord.At skin irritatin in 1,24,48 hour reaction integral mean value is 0.08 minute.Embodiment 1-4 and 6 and the effect of embodiment 5 do not have remarkable difference, the Therefore, omited narration.
Conclusion:, prove that medicine of the present invention is to the skin nonirritant according to the skin irritatin grade scale.
Medicine clinical practice of the present invention is summed up:
One, clinical data
1, medication index: all patient's readme leucorrhea increasings, the bean dregs appearance that is white in color, pruritus vulvae, cusalgia, painful unusual person, gynecologial examination vulva, vagina mucosa hyperemia, and with white membranoid substance.
2, administrated method: the patient converts 9 times of water (calling medicine of the present invention in the following text) with present embodiment 1-6 invention medicine and cleans vulva for 10 milliliters, and vagina every day 1-2 time, 7-10 days is a course of treatment.
3, criterion of therapeutical effect: transference cure after the medication, the normal person of leukorrhea routine test is for curing.The sx person is for taking a turn for the better after the medication; Symptom does not disappear, and leukorrhea is chemically examined unusual person for invalid.
Two treatment results:
1, symptom changes: see table 1:
Figure BSA00000655759800101
Figure BSA00000655759800111
2, result of treatment is seen table 2
Curative effect The example number Percentage (%)
Recovery from illness 28 93.33%
Take a turn for the better 3 6.66%
Invalid 0 0
Amount to 30 100%
Through observing 30 examples with medicine treatment colpomycosis of the present invention, 93.33%6 more; 6.669/0 take a turn for the better, efficient 100%, we think that this medication imitates well, welcome by the patient.Can become one of our the most frequently used women's good medicine.
The example 1 the week so-and-so; 60 years old.Married, main suit's pruritus vulvae is scorching hot, pain, leukorrhea are many: sit during severe symptoms and rather keep down, with frequent micturition, odynuria is half a year.Both: toward diabetes, coronary heart disease and cataract medical history are arranged: once go to too much home hospitalize.Obviously do not imitate rolling and treat, after with medicine embodiment one treatment of the present invention three times, the readme miracle has occurred, and can sleep well, and has used 6-7 days again continuously, and all malaise symptoms all disappear, and from slight illness, free, and are very grateful.
Example 2 Lee xx are 31 years old, married; Readme itching of vulva, leukorrhea are many, are bean dregs appearance, and all have an attack of one's old illness annual summer; Not only oneself violated disease summer in this year, its husband's genitalia severity of scratching where it itches, and two people are simultaneously with medicine embodiment two treatments of the present invention; Two people's symptoms disappear very soon, and the toposcopy inflammation disappears, and pay a return visit and cure not recurrence of back.
3 xx of example, 24 years old, married, the readme itching of vulva; Leukorrhea is many, and peculiar smell is arranged, frequent micturition, odynuria, intercourse pain; Be regardless of occasion when serious, wiping must be scratched in the place, oneself feels very painful and shy, used medicine embodiment three of the present invention to treat transference cure after a course of treatment, and exposed the smile on the face.
4 xx of example are 29 years old, married.Readme itching of vulva pain, leukorrhea is many especially, is bean dregs appearance, through treating several days symptom transference cures with medicine embodiment four of the present invention.Return visit is learnt, more not recurrence of back.
Example 5 Hao xx, 19 years old unmarried.Yan Shu is after going Bei Dai River swimming, and vulva is very itched; Carry and increase.Peculiar smell is arranged, and blue do not have with medicine embodiment five treatment 6-7 of the present invention, and malaise symptoms disappears, and carries to transfer to normally.
Example 6 is contained xx, 10 years old, unmarried.Readme is this time in the period used others two sanitary napkins after, vulva is very itched, menostaxis 3 days; Color is unusual, and the clean back of menstruation leucorrhea increasing is bean dregs appearance: painful unusual: as to be ashamed of hospital treatment again; After treating a course of treatment, gone a worry with medicine embodiment six of the present invention.
Example 7 Jin xx are 26 years old, married.Readme is itching of vulva from the swimming back, and leucorrhea increasing is white in color, and peculiar smell is arranged, and simultaneously with frequent micturition, odynuria, once specially controls the diagnosis and treatment of gynaecological disease clinic at individuality.Result of treatment is not obvious, and after with medicine embodiment one treatment of the present invention, effect is splendid: symptom disappears very soon, and return visit is learnt, not recurrence after the self-healing.
Example 8 ginger xx are 25 years old, married.The readme pruritus vulvae.Cusalgia, intercourse pain, leukorrhea are many especially, are bean dregs appearance, and peculiar smell is arranged.The husband does not understand, own misery very much, after with medicine embodiment of the present invention two treatments, transference cure.The man and wife gets togather as before.
Example 9 blue so-and-so, 38 years old, married.The readme itching of vulva, leukorrhea is many, is from the color lump shape, with frequent micturition, odynuria; Intercourse pain also has symptoms such as hemorrhage, and it is not remarkable once to treat a few days effect, through treating two courses of treatment with medicine embodiment three of the present invention; Miracle has occurred, transference cure, and the postcoital bleeding phenomenon has not had yet.
Example, 10 king xx are 28 years old, married.The readme itching of vulva, leukorrhea is many, and bulk is white in color: with intercourse pain and bleeding is arranged; Menstruation is inaccurate, often in advance or after the mistake, and repeatedly treatment once; Violate during fashion, oneself be afraid of not only but also worried, transference cure after treating two courses of treatment with medicine embodiment four of the present invention; Also do not have an attack of one's old illness in many days, menstruation is also normal, and the slight illness that can remove oneself for this medicine is with worried glad.
Example 11 Liu xx are 30 years old, married.Yan Shu vulva after going out is very itched.Leucorrhea increasing, bulk is white in color; There is tunica albuginea to come off when washing,, makes and oneself feel restless with frequent micturition, urgent urination, odynuria, can not be quiet sleeping, be in extreme agony, through treating a course of treatment with medicine embodiment four of the present invention, symptom disappears entirely.
12 xx of example are 32 years old, married.Readme has been used once behind the sanitary napkin that small shop buys, and vulva is very itched incomparably, and leucorrhea increasing with frequent micturition, odynuria, through with 2-3 days transference cures of medicine embodiment five treatments of the present invention, continues use a course of treatment, recurs after healing.
Example 13 old xx are 30 years old, married.Readme itching of vulva pain, leucorrhea increasing is bean dregs appearance, and symptom disappears very soon after treating with medicine embodiment six of the present invention.
Example 14 cutter xx are 26 years old, married.Readme itching of vulva pain, leucorrhea increasing disappears with medicine embodiment one treatment back symptom of the present invention very soon.
Example 15 is in xx, and is 29 years old, married.Readme pruritus vulvae 2-3 days, leucorrhea increasing: symptom rapidly disappears after treating with medicine embodiment two of the present invention.
Example xx 16 Wei is 27 years old, married.The readme vulva is scratched pain, is very itched, leucorrhea increasing, and white with the vulva cusalgia, is liked blowing, and influence sleep is through with 31 courses of treatment of medicine embodiment of the present invention; Transference cure.
Example 17 grandson xx are 27 years old, married.Readme pregnant May, itching of vulva, leucorrhea increasing.Be bean dregs appearance more. frowziness, be afraid of that medication is unfavorable to fetus, so not treatment; Recently sx, the pain of itching is impatient at, through with 41 courses of treatment of medicine embodiment of the present invention; Transference cure, for fear of infecting fetus, suggestion is local to last till pregnant August with medicine treatment of the present invention.1
Example 18 grandson xx are 25 years old, married.Readme swimming back frequent micturition, urgent urination, odynuria, itching of vulva, leucorrhea increasing arrives first the internal medicine diagnosis and treatment, frequent micturition, urgent urination, odynuria transference cure, but vulva still itches, and leukorrhea does not have minimizing, and after treating a course of treatment with medicine embodiment five of the present invention, symptom all disappears.
Example 19 Lee xx, 30 years old, itching of vulva pain behind the sauna bath, one week of leucorrhea increasing were washed in readme.Produce effects not after oneself is washed with the liquid medicine bought, after treating with medicine embodiment six of the present invention, symptom disappears very soon.
Example 20 Zhao xx, 33 years old, married, the readme itching of vulva, leucorrhea increasing, the bulk that is white in color, with frequent micturition, urgent urination, odynuria, after with medicine embodiment one treatment of the present invention, symptom disappears very soon.
Example 21 old xx, 29 years old, married, the readme itching of vulva; That the their early stage leukorrhea is is yellow, amount is many, peculiar smell is arranged, and does not take notice of, the sx afterwards of going swimming, and vulva is very itched; Leukorrhea is more increased, and is mixed with white like bean dregs appearance, after treating a course of treatment with medicine embodiment three of the present invention; Sx continues with after the course of treatment transference cure.
Example 22 king xx, 40 years old; Married, readme pruritus vulvae, cusalgia, are felt restless when serious at leucorrhea increasing half a year; Can not fall asleep, only scratch and grab or firmly wipe raft with cloth and could remove except that the discomfort of itching: but burning heat sensation is felt in the part subsequently, pain, skin is frayed very soon to fester; Through several families hospital therapy, unsatisfactory curative effect is after with 42 course of therapy of medicine embodiment of the present invention; Symptom obviously alleviates, and local ulcer heals basically, is continuing treatment at present.
Example 23 is worn xx, and 49 years old, married, the readme external genital was scratchy, burn and pain, leucorrhea increasing, and the curdled milk that is white in color bulk, through with the medicine embodiment transference cure course of treatment on May Day of the present invention, return visit is learnt, recurs so far.
Example 24 model xx, woman, 32 years old are married. the readme vulva is very itched, and burning heat sensation is arranged, leucorrhea increasing, the bean dregs appearance that is white in color has peculiar smell, does not feel any better through symptomatic treatment.The back is with medicine embodiment of the present invention six treatments malaise symptoms disappearance after 10 days, and it is three normal that leukorrhea transfers to, follows up a case by regular visits to and do not see recurrence.
Example 25 relies xx, and the woman is 32. years old, married.Readme is this time gone on business to south: because of having used public bathtub, cause private parts very to be itched, leucorrhea increasing is bean dregs appearance; Peculiar smell is arranged. through the diagnosis and treatment of suiting the medicine to the illness, do not feel any better, painful unusual, come my institute's diagnosis and treatment; After treating a course of treatment with medicine embodiment one of the present invention, above transference cure is paid a return visit and is not seen recurrence.,
Example 26 poplar xx, the woman, 25 years old, married, the readme external genital was itched bitterly, and leucorrhea increasing has peculiar smell.Warp is treated a course of treatment with medicine embodiment two of the present invention, above transference cure, and leukorrhea also transfers to normally.
Example 27xx, the woman is 32 years old, married.Say that stating external genital itches bitterly, leucorrhea increasing is the white peas or beans slag specimen, and unusual stink is arranged, and is very painful, and a course of treatment is treated with medicine embodiment three of the present invention in the back, and above malaise symptoms all disappears.
The example 28 Jin xx, the woman, 44 years old, married: readme over nearly more than ten days external genital scratch ancient term for country school; Vaginal fluid increases, and is white in color! Personal PP powder cleans external genital with salt solution and does not see positive effect, and symptom day by day increases the weight of, and after treating a course of treatment with medicine embodiment four of the present invention, above malaise symptoms all disappears.
Example 29 money xx, the woman is 44 years old, married.Readme is itched at swimming pool swimming beginning in second day private parts, and adularescent look secretion, clean and one week of oral anti-inflammatory drug thing with the PP powder voluntarily, and DeGrain, after treating a course of treatment with medicine embodiment five of the present invention, the private parts disappearance of scratching where it itches, leukorrhea is also normal.
Example 30 grandson xx, the woman, 20 years old, unmarried, readme unknown cause in the last few days caused that external genital itches, with pain, leucorrhea increasing has peculiar smell, cleans external genital with light salt brine voluntarily, poor effect, treat a course of treatment with medicine embodiment six of the present invention after.Above-mentioned symptom disappears, and patient is very delight.

Claims (9)

1. Chinese herbal medicine biological antiseptic liquid, it is characterized in that following materials of weight proportions medicine processes original liquid through alcohol precipitation: Herba Andrographitis 40-120, santonin 40-120, Celastrus angulatus 35-105, camphor tree 35-105, Fourstamen Stephania Root 35-105, Azalea pontica 35-105, macleaya cordata 30-90, granatum 30-90, root of Chinese clematis 30-90, tuber of stemona 30-90, Da Ye press 30-90, kuh-seng 30-90, root bark of shaggy-fruited dittany 25-75, azedarach 25-75, corydalis tuber 25-75, Radix Glycyrrhizae 25-75;
Original liquid is blended into the usnic acid sodium of 0.01-0.03% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.
2. according to the said thimerosal of claim 1, it is characterized in that Herba Andrographitis 80, santonin 80, Celastrus angulatus 70, camphor tree 70, Fourstamen Stephania Root 70, Azalea pontica 70, macleaya cordata 60, granatum 60, the root of Chinese clematis 60, the tuber of stemona 60, Da Ye by 60, kuh-seng 60, the root bark of shaggy-fruited dittany 50, azedarach 50, corydalis tuber 50, Radix Glycyrrhizae 50;
Original liquid is blended into the usnic acid sodium of 0.02% weight ratio, and usnic acid sodium is used dissolution with solvents earlier, is blended in the original liquid and processes.
3. according to claim 1 or 2 said thimerosals, it is characterized in that the first dissolved in purified water of said usnic acid sodium with the 1.5-3 times of weight.
4. according to claim 1 or 2 said thimerosals, it is characterized in that said alcohol precipitation is said bulk drug to be decocted the concentrated intermediate in back carry out alcohol precipitation.
5. according to the said thimerosal of claim 4; It is characterized in that earlier said bulk drug being soaked into before the said decoction, said decocting time is 1-1.5 hour, adds the water of 1.5-2 times of weight during said the decoction; The said alcohol precipitation time is 48 hours, and said alcohol precipitation uses 75% alcohol.
6. according to the said thimerosal of claim 5, it is characterized in that earlier said bulk drug being carried out the rinsing impurity elimination before the said infiltration.
7. according to the said thimerosal of claim 6, it is characterized in that before said infiltration or rinsing impurity elimination, earlier said bulk drug being pulverized.
8. according to claim 1 or 2 said thimerosals; It is characterized in that said camphor tree be camphor tree tree root, or set bar or branch or camphor or camphorated oil, when using camphor or camphorated oil by tree root, or set the corresponding decrement adapted of the content that can take camphor or camphorated oil in bar or the branch.
9. according to claim 1 or 2 said thimerosals, it is characterized in that said finished product: content 0.2% creat lactone, color are brownish red, ph7-8, density 1.10g/cm 3
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CN103392749A (en) * 2013-08-19 2013-11-20 葛秀萍 Traditional Chinese medicine disinfecting liquid for disinfecting operation room apparatus and preparation method thereof
CN104208357A (en) * 2014-01-24 2014-12-17 徐兴利 Antibacterial Chinese herbal medicine liquid for spray-coating wounds
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CN103800628A (en) * 2014-03-18 2014-05-21 王文珠 Medicament for disinfecting before anesthesia operation
CN104383570A (en) * 2014-11-26 2015-03-04 南京正宽医药科技有限公司 Mixed disinfection type medical equipment disinfection cabinet
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CN106259531A (en) * 2016-08-03 2017-01-04 覃燕兰 A kind of Toys Disinfection liquid
CN107996067A (en) * 2018-01-17 2018-05-08 安徽省华禾种业有限公司 A kind of method for improving seed of bitter gourd germination percentage
CN108156881A (en) * 2018-01-17 2018-06-15 安徽省华禾种业有限公司 A kind of method for improving violet cabbage percentage of seedgermination
CN113491740A (en) * 2020-04-01 2021-10-12 生物源生物技术(深圳)股份有限公司 Composition for preventing and treating candida albicans disease and medicine and feed additive containing same
CN113491740B (en) * 2020-04-01 2022-05-27 生物源生物技术(深圳)股份有限公司 Composition for preventing and treating candida albicans disease and medicine and feed additive containing same
CN113197214A (en) * 2021-04-26 2021-08-03 江苏省中国科学院植物研究所 Application of tetrandrine as agricultural bactericide

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