CN104208357A - Antibacterial Chinese herbal medicine liquid for spray-coating wounds - Google Patents
Antibacterial Chinese herbal medicine liquid for spray-coating wounds Download PDFInfo
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Abstract
The invention relates to an antibacterial Chinese herbal medicine liquid for spray-coating wounds. The antibacterial Chinese herbal medicine liquid solves the problem that the existing disinfectant has high irritation. Extract of Chinese herbal medicines as raw materials subjected to alcohol precipitation is added with purified water having the weight 7-11 times that of the extract so that a water-soluble raw medicine is obtained, and the water-soluble raw medicine is added with usnic acid sodium salt so that the desired product is obtained; or the extract of the Chinese herbal medicines as raw materials subjected to alcohol precipitation is added with a part of purified water so that a water-soluble raw medicine is obtained and then an usnic acid sodium salt aqueous solution prepared from usnic acid sodium salt and the other part of the purified water is added into the water-soluble raw medicine so that the desired product is obtained, wherein a weight ratio of the extract subjected to alcohol precipitation to the two parts of purified water is 1: 7-11 and a weight ratio of usnic acid sodium salt to the water-soluble raw medicine is 1.5-3: 1000. The Chinese herbal medicines as raw materials comprises, by weight, 50-110 parts of common andrographis herb, 50-110 parts of cortex phellodendri, 40-100 parts of radix berberidis, 40-100 parts of Celastrus angulatus, 40-100 parts of isatis root, 40-100 parts of radix sophorae flavescentis, 40-80 parts of mulberry bark, 40-80 parts of santonin, 40-80 parts of aloe, 40-80 parts of fructus rosae laevigatae, 40-80 parts of akebia stem, 40-80 parts of subprostrate sophora, 30-70 parts of Sichuan red orange peel, 30-70 parts of rheum officinale, 30-70 parts of corydalis tuber and 30-70 parts of licorice root. The antibacterial Chinese herbal medicine liquid has the advantages of small irritation, lasting disinfection effect, short treatment course and use convenience.
Description
Technical field
The present invention relates to a kind of wound disinfectant, particularly relate to a kind of wound spray Chinese herbal antibacterial liquid.
Background technology
The sterilizing disinfectant that current wound is conventional, as hydrogen peroxide, ethanol etc., often zest is strong, and Disinfection Effect is of short duration, is inconvenient to use.
Summary of the invention
The object of the invention is the above-mentioned defect overcoming prior art, and provide a kind of zest little, effect is longer, wound spray Chinese herbal antibacterial liquid easy to use.
For achieving the above object, wound of the present invention spray Chinese herbal antibacterial liquid is that following bulk drugs precipitate with ethanol extract is first converted 7-11 times of weight pure water and obtained water-soluble former medicine, then blends and obtain into loose square-bottomed bamboo basket acid sodium; Or following bulk drugs precipitate with ethanol extract convert 7-11 times of weight dissolve in loose square-bottomed bamboo basket acid sodium pure water obtain; Or following bulk drugs precipitate with ethanol extract is first blended into a part of pure water and obtains water-soluble former medicine, to be blended in described water-soluble former medicine obtained by the loose square-bottomed bamboo basket acid sodium aqueous solution after another part pure water being blended into loose square-bottomed bamboo basket acid sodium again, the weight ratio of described precipitate with ethanol extract and described two parts pure water is 1: 7-11;
The weight ratio of pine square-bottomed bamboo basket acid sodium and described water-soluble former medicine is 1.5-3: 1000; Described crude drug weight proportion is: Herba Andrographis 50-110, Cortex Phellodendri 50-110, Radix Berberidis 40-100, Celastrus angulatus 40-100, Radix Isatidis 40-100, Radix Sophorae Flavescentis 40-100, Cortex Mori 40-80, Santonin 40-80, Aloe 40-80, Fructus Rosae Laevigatae 40-80, Caulis Akebiae 40-80, Radix Sophorae Tonkinensis 40-80, the red withered skin 30-70 in Sichuan, Radix Et Rhizoma Rhei 30-70, Rhizoma Corydalis 30-70, Radix Glycyrrhizae 30-70.
Composition principle:
One, monarch drug; Namely the medicine of primary treatment effect is played for main disease or main symptom, mainly indispensable in the side of being.Monarch drug; Herba Andrographis, Cortex Phellodendri.Nature and flavor; Bitter, cold.Function; Heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness.Have staphylococcus aureus ， Green pus bacillus, Bacillus proteus, Diplococcus pneumoniae, Hemolytic streptococcus, dysentery bacterium, Bacillus typhi, gram positive bacteria, gram negative bacteria, and influenza virus, arbovirus, Si adenitis disease all has inhibitory action, can strengthen the phagocytic activity of human leukocytes to antibacterial, can immunologic function be increased, have obvious antipyretic response.It is the indispensable monarch drug of main formula; Herba Andrographis, Cortex Phellodendri.
Two ministerial drugs; There are two kinds of meanings.Ministerial drug; Radix Berberidis, Celastrus angulatus, Radix Isatidis, Radix Sophorae Flavescentis.Nature and flavor; Bitter, cold, function; Heat clearing and damp drying, eliminating fire and detoxication, sterilization, parasite killing.
1, auxiliary monarch drug strengthens the main disease for the treatment of or main symptom.There is heat-clearing and toxic substances removing.Resisting pathogenic microbes effect, to dysentery bacterium, Bacillus typhi, tubercule bacillus, staphylococcus aureus, Hemolytic streptococcus, multiple malignant bacteria and dermatophytes and leptospira etc. all have inhibitory action.
2, primary treatment effect is played for double disease or double disease.There is heat clearing and damp drying, eliminating fire and detoxication.To staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, dysentery bacterium, escherichia coli; Green pus bacillus, Bacillus proteus, concentric hair moss bacterium, is permitted the yellow moss bacterium of Lan Shi, rust little spore moss bacterium, ulotrichy little spore moss bacterium, groin epidermis moss bacterium, star nocardia all has inhibitory action.Can also strong inhibition Candida albicans, antitumor, the effects such as leukocyte increasing.
Three, adjuvant drug; There are three kinds of meanings.Adjuvant drug; Cortex Mori, Santonin, Aloe, Fructus Rosae Laevigatae, Caulis Akebiae, Radix Sophorae Tonkinensis.Nature and flavor; Pungent, sweet, flat, bitter, cold.Function; Heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling, coordinating the actions of various ingredients in a prescription, neutralizes a toxin.
1, supplementary drug; Namely coordinate monarch, ministerial drug to strengthen therapeutical effect, or directly treat the medicine of minor symptom.Function; Heat-clearing and toxic substances removing, parasite killing.Help monarch, minister phase and, make; Monarch, minister is strengthened treatment or is directly treated minor symptom.Have Bacillus typhi, escherichia coli, tubercule bacillus, dysentery bacterium, staphylococcus aureus.Hemolytic streptococcus, vibrio cholera, leprosy bacillus, Ru shape epidermophyton, Candida albicans, dermatophytes and leptospira, gram positive bacteria, gram negative bacteria, the diseases such as skin pruritus all have inhibitory action.
2, supplementary inhibitory medicine; Namely in order to eliminate or to weaken monarch, the toxicity of ministerial drug, maybe monarch can be restricted, the medicine of the property that ministerial drug thing (by force) is strong.Function; Heat-clearing and toxic substances removing.Have and eliminate or weaken monarch, the toxicity of ministerial drug, restricts monarch simultaneously, the property that ministerial drug thing (by force) is strong.The composition of prescription; Have and hundred medicines, separate the effect of hundred poison.The effect of the mediation property of medicine can be played in prescription; By removing toxic substances, the property that the poison of prescription Chinese medicine is strong can be reduced.Have Hemolytic streptococcus, staphylococcus aureus, Bacillus typhi, diphtheria corynebacterium, dysentery bacterium, escherichia coli ， Green pus bacillus, bacillus enteritidis, the multiple pathogenic coccus such as clostridium tetani and bacillus all have bacteriostasis.There is the effects such as the toxin eliminated prescription Chinese medicine or weaken prescription Chinese medicine simultaneously.To human non-toxic, harmless, have no side effect, no dependence.
3, corrigent; Namely seriously ill heresy very, and when may refuse to take medicine, adapted is contrary with monarch drug nature and flavor and can play the medicine of phase same-action in the treatment.Function; Heat-clearing and toxic substances removing.Adapted Fructus Rosae Laevigatae nature and flavor; Sour, puckery, flat.Rhizoma Corydalis nature and flavor; Acrid, bitter, warm.Although contrary with monarch drug nature and flavor but all have and to strengthen and potentiation monarch drug sterilizes jointly, parasite killing, antiviral strength.Have gram positive bacteria and gram negative bacteria, dysentery bacterium, escherichia coli, leptospira and influenza virus all have inhibitory action.
Four, medicine is made; There are three kinds of meanings.Adjuvant drug; Sichuan Citrus reticuiata Blano, Radix Et Rhizoma Rhei, Rhizoma Corydalis, Radix Glycyrrhizae.Nature and flavor; Pungent, bitter, sweet, warm, flat.Function; Heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, coordinating the actions of various ingredients in a prescription.Have and hundred medicines, separate the effect of hundred poison.(book on Chinese herbal medicine converges and says) " with middle QI invigorating, the medicine of tonify deficiency removing toxic substances also ".
1, guiding drug; Can in the side of drawing all medicines to sick medicine.Function; Heat clearing and damp drying, eliminating fire and detoxication.Have and introduce prescription Chinese medicine, help monarch, minister, help, make medicine phase and, make monarch, minister, help, make medicine form prescription to have synergism, can strengthen or synergistic antimicrobial, antiviral effect.Have multiple gram positive bacteria, gram negative bacteria and tetanus toxin, antiinflammatory, antibacterial, protozoacide, antiviral etc. all have inhibitory action.
2, harmonizing drug; Namely there is the medicine of all medicine effects in mediation side.Function; Dampness, invigorate blood circulation, circulation of qi promoting, pain relieving.Have and hundred medicines, the effect of separating hundred poison.Can be in harmonious proportion the effect of prescription Chinese medicine, help monarch, minister, help, medicine is harmonious, make monarch, minister, help, make medicine play mediation effect at prescription Chinese medicine, strengthen total synergism, can strengthen or synergistic antimicrobial, antiviral effect.
Book on Chinese herbal medicine is " taste, to bitter, obtains the property of neutralization, therefore its poison of solution that poison obtains, and firm medicine obtains its property of sum also " just.
Prove after testing: medical instrument of the present invention has multiple gram positive bacteria, gram negative bacteria, staphylococcus aureus, and bacillus enteritidis ， Green pus bacillus and dermatophytes all have inhibitory action.Anti-ameba, kills trichomonas vaginitis.Medicine of the present invention also has that zest is little, and effect is longer, advantage easy to use.
As optimization, described crude drug weight proportion is: Herba Andrographis 80, Cortex Phellodendri 80, Radix Berberidis 70, Celastrus angulatus 70, Radix Isatidis 70, Radix Sophorae Flavescentis 70, Cortex Mori 60, Santonin 60, Aloe 60, Fructus Rosae Laevigatae 60, Caulis Akebiae 60, Radix Sophorae Tonkinensis 60, the red withered skin 50 in Sichuan, Radix Et Rhizoma Rhei 50, Rhizoma Corydalis 50, Radix Glycyrrhizae 50.
As optimization, described extract is blended into the pure water of 9 times of weight or the weight ratio of described precipitate with ethanol extract and described two parts pure water is 1: 9; The weight ratio of pine square-bottomed bamboo basket acid sodium and described water-soluble former medicine is 2: 1000.
As optimization, described precipitate with ethanol extracts and in turn includes the following steps: and crude drug remove impurity-rinsing-steaming and decocting-concentrating-ol sinks-and recovery ethanol is obtained.
As optimization, described steaming and decocting be crude drug after rinsing add water steaming and decocting, filter to get filtrate, it is described that concentrated to be that described filtrate is concentrated to obtain concentrate, described precipitate with ethanol be described concentrate with 75% ethanol precipitate with ethanol 48 hours obtained precipitate with ethanol extracts.
Fabrication processing is; By recipe quantity dispensing → remove impurity (mainly soil assorted) → rinsing → steaming and decocting (kingfisher is got) → concentrated → precipitate with ethanol (48 hours, precipitate with ethanol use the ethanol of 75%) → reclaim ethanol → warehouse-in → storage → use.Convert pure water quantity or convert pure water and loose square-bottomed bamboo basket acid sodium quantity preferably meet one ton of Chinese herbal medicine, produce one ton of the present invention and to sterilize medicinal liquid.The antimicrobial fluid of the present invention made is distributed in spray bottle, and every bottle preferably fills 20 milliliters.
The medicine scope of application of the present invention: can be used for wound sterilization, sterilization before injection, pre-operation sterilization, Medical treatment device guards against sterilization, sterilization in aircraft passenger compartment, sterilization in passenger car, sterilization in bus, sterilization in taxi, sterilization in swimming pool, sterilizes in public place, sterilize in restaurant, table ware, in family, cleaning vegetable disinfectant etc.
Invention antimicrobial fluid of the present invention, prove through " China Academy of TCM " and " Beijing legendary god of farming's pharmaceutical developments institute bacteriostatic test ", " basis institute of Beijing University of Chinese Medicine microbiology, immunology teaching and research room " extracorporeal bacteria inhibitor test and " Chinese Academy of Medical Sciences, Institute of Medicinal Biological Technique " examining report; Very strong inhibit feature is all had to gram positive bacteria, gram negative bacteria, antibacterial, brood cell bacterium and fungus (as Candida albicans, Aspergillus niger).Mycoplasma---the Candida albicans of the coccus vaginitis disease of the thought that particularly gynecological's sickness rate is very high, and the gonococcus to gonorrhea, cervical erosion, urea decomposition mycoplasma, infect the virus of condyloma acuminatum, infecting phallic herpes simplex virus has very strong inhibitory action.Reach absolutely through clinical proof effective percentage.
After adopting technique scheme, it is little that wound spray Chinese herbal antibacterial liquid of the present invention has zest, and Disinfection Effect is long, short treating period, advantage easy to use.
Detailed description of the invention
Wound of the present invention spray Chinese herbal antibacterial liquid is that following bulk drugs precipitate with ethanol extract is converted 7 or 9 or 11 times of weight pure water and obtained water-soluble former medicine, blend the obtained or described loose square-bottomed bamboo basket acid sodium of loose square-bottomed bamboo basket acid sodium to be more first dissolved in described pure water, then obtain miscible to obtained loose square-bottomed bamboo basket acid sodium aqueous solution and described precipitate with ethanol extract.(also can be or following bulk drugs precipitate with ethanol extract is first blended into a part of pure water and obtains water-soluble former medicine, to be blended in described water-soluble former medicine obtained by the loose square-bottomed bamboo basket acid sodium aqueous solution after another part pure water being blended into loose square-bottomed bamboo basket acid sodium again, the weight ratio of described precipitate with ethanol extract and described two parts pure water is 1: 7-11).
The weight ratio of pine square-bottomed bamboo basket acid sodium and described water-soluble former medicine is 1.5 or 2 or 3: 1000; Convert pure water quantity or convert pure water and loose square-bottomed bamboo basket acid sodium quantity preferably meet one ton of Chinese herbal medicine, produce one ton of the present invention and to sterilize medicinal liquid.
Described crude drug weight proportion is A: Herba Andrographis 50 kilograms, Cortex Phellodendri 110 kilograms, Radix Berberidis 40 kilograms, Celastrus angulatus 100 kilograms, Radix Isatidis 40 kilograms, Radix Sophorae Flavescentis 100 kilograms, Cortex Mori 40 kilograms, Santonin 80 kilograms, Aloe 40 kilograms, Fructus Rosae Laevigatae 80 kilograms, Caulis Akebiae 40 kilograms, Radix Sophorae Tonkinensis 80 kilograms, the red withered skin 30 kilograms in Sichuan, Radix Et Rhizoma Rhei 70 kilograms, Rhizoma Corydalis 30 kilograms, 70 kilograms, Radix Glycyrrhizae.
Described crude drug weight proportion is B: Herba Andrographis 110 kilograms, Cortex Phellodendri 50 kilograms, Radix Berberidis 100 kilograms, Celastrus angulatus 40 kilograms, Radix Isatidis 100 kilograms, Radix Sophorae Flavescentis 40 kilograms, Cortex Mori 80 kilograms, Santonin 40 kilograms, Aloe 80 kilograms, Fructus Rosae Laevigatae 40 kilograms, Caulis Akebiae 80 kilograms, Radix Sophorae Tonkinensis 40 kilograms, Sichuan Citrus reticuiata Blano 70 kilograms, Radix Et Rhizoma Rhei 30 kilograms, Rhizoma Corydalis 70 kilograms, 30 kilograms, Radix Glycyrrhizae.
Described crude drug weight proportion is C: Herba Andrographis 80 kilograms, Cortex Phellodendri 80 kilograms, Radix Berberidis 70 kilograms, Celastrus angulatus 70 kilograms, Radix Isatidis 70 kilograms, Radix Sophorae Flavescentis 70 kilograms, Cortex Mori 60 kilograms, Santonin 60 kilograms, Aloe 60 kilograms, Fructus Rosae Laevigatae 60 kilograms, Caulis Akebiae 60 kilograms, Radix Sophorae Tonkinensis 60 kilograms, Sichuan Citrus reticuiata Blano 50 kilograms, Radix Et Rhizoma Rhei 50 kilograms, Rhizoma Corydalis 50 kilograms, 50 kilograms, Radix Glycyrrhizae.
Described precipitate with ethanol extracts and in turn includes the following steps: and crude drug remove impurity-rinsing-steaming and decocting-concentrating-ol sinks-and recovery ethanol is obtained.Described steaming and decocting be crude drug after rinsing add water steaming and decocting, filter to get filtrate, it is described that concentrated to be that described filtrate is concentrated to obtain concentrate, described precipitate with ethanol be described concentrate with 75% ethanol precipitate with ethanol 48 hours obtained precipitate with ethanol extracts.
Adopt the laboratory detection result of the medicine of the present invention of technique scheme as follows:
There are following three kinds for experiment or the medicine of the present invention of clinical observation: namely, convert 11 times of weight pure water, medicine of the present invention that loose square-bottomed bamboo basket acid sodium obtains when being 1.5: 1000 with the weight ratio of described water-soluble former medicine and adopting described crude drug weight proportion to be above-mentioned A proportioning is No. 1 medicine; Convert 9 times of weight pure water, medicine of the present invention that the weight ratio of the acid of loose square-bottomed bamboo basket sodium and described water-soluble former medicine obtains when being 3: 1000 and adopting described crude drug weight proportion to be above-mentioned B proportioning is No. 2 medicines; Convert 7 times of weight pure water, medicine of the present invention that the weight ratio of the acid of loose square-bottomed bamboo basket sodium and described water-soluble former medicine obtains when being 2: 1000 and adopting described crude drug weight proportion to be above-mentioned B proportioning is No. 3 medicines.
Adopt 1), positive strain: cured sample bacillus, bacillus subtilis, staphylococcus 209P, sarcina.2), negative strain: escherichia coli 0-111, bacillus pyocyaneus, Bacillus proteus X0-19, Klebsiella pneumonia.3) fungus: Candida albicans, Aspergillus niger.
1), antibacterial culture medium is adopted:: broth bouillon.2), fungus: Sabouraud culture medium.
Experimental technique: liquid dilution method.
Experimental result:
Note: MIC is minimum inhibitory concentration.
Medicine of the present invention is used for the treatment of ulcus cruris trauma infection contamination wound surface and the routine clinical observation material of Prepuce balanitis 20 is as follows:
Be below merge ulcer, wound postoperative infection formation wound surface and glans penis, acrobystitis external application or local painting to shank vein inflammation to wash 20 examples, obtain promising result.Now be reported as follows:
One, clinical data
1. shank vein inflammation merges ulcer 6 example
(1) Lee is high, man, 68 years old: left leg inside lower end is red, swollen, hot, pain 3 days.Its inflammation central authorities ulcer area 4 × 3cm.
(2) Wang's meeting, man, 61 years old: in left leg, ankle festers 2 days, area 5 × 3cm, periphery was red and swollen, Pi Wengao.
(3) certain core is closed, man, 78 years old: right lower extremity is inside and outside ankle point, lamellar ulcer 10 because varicosis merges
+my god, large person about 1.5 × 1cm.
(4) to go into business certain flower, female, 56 years old: right lower extremity phlebitis merges ulcer 3 days, ulcer area about: 5 × 3cm.
(5) Chen age, man, 70 years old: left leg lateral superficial veins inflammation merges point, lamellar festers two weeks, area 12 × 7.T：37℃。
(6) Zhang's stamen, female, 67 years old: for many years, skin is brown to two lower limb lower ends superficial phlebitis, is dispersed in point, lamellar ulcer is prolonged does not heal.Body temperature 37 DEG C.
2. trauma infection contamination wound surface 2 example:
(1) Wang, man, 19 years old: right hand trauma infection contamination 7 days, right hand back of the body outside wound surface 3 × 2.5cm, wound granulation was gloomy, stale.
(2) soldier Lee, man, 26 years old: left thigh is gone through because of traffic accident wound, and traumatic infection 10 days, wound surface is 6 × 3cm about, disunion.
3. foreskin, balanitis 12 example:
(1) going into business, certain is outstanding, man, 21 years old: foreskin, glans penis are red, swollen, without festering.
(2) Wang woods, man, 28 years old: main cause glans penis, coronary sulcus place strip ulcer 10
+my god, face 0.5 × 0.5,0.5 × 0.3cm, large young waiter in a wineshop or an inn place.
(3) Lee's victory, man, 18 years old: foreskin, glans penis place are scratchy, micro-red and swollen pain 2 days.
(4) Lee, man, 24 years old: main cause glans penis, coronary sulcus place needle point size pimple 2 days, pruritus.
(5) Chen mountain, man, 20 years old: foreskin length can not be turned up to coronary sulcus, causes foreskin red, swollen 1 day.
(6) Guo is complete, man, 19 years old: glans penis, crown place ditch needle point size pimple 4 days, and mild redness.
(7) Lee mountain, man, 36 years old: foreskin is long, but can turn over to coronary sulcus.Conscious local is scratchy, mild redness, and coronary sulcus place is loose pimple.
(8) Zhang, man, 30 years old: red and swollen after foreskin mosquito bite, rear diabrosis stream yellow fluid, pruritus etc.
(9) journey river, man, 19 years old: redundant prepuce causes local infection, scratchy etc.
(10) Chen is raw, man, 24 years old: redundant prepuce, and coronary sulcus place is loose pimple, rubescent.
(11) Chen, man, 29 years old: main cause foreskin, glans penis place discomfort, pruritus, crown head place was red and swollen, pimple a couple of days.
(12) face strength, man, 23 years old: glans penis, acrobystitis, pruritus, coronary sulcus place pimple.
Two, Therapeutic Method
For forming traumatic infection after ulcer and wound because of shank vein inflammation, apply medicine spray 20-30ml of the present invention every day, 3-4 times/day of sprayed coating, is used in conjunction 2-3 week, and wherein 2 examples have used antibiotics 1 week because fever adds.Local cleaning, spraying are all adopted for foreskin, balanitis.10-20ml, secondary 3/ day.Wherein shank vein inflammation merges 1-2 example in ulcer 6 example, 3-4 is routine, 5-6 is routine uses above-mentioned 1,2, No. 3 medicine respectively.In trauma infection contamination wound surface 2 example the 1st, 2 examples use above-mentioned 2nd, No. 3 medicine respectively.1-4,5-8,9-12 medicine in foreskin, balanitis 12 example uses the 1st, 2, No. 3 medicine respectively.
Three, efficacy determination
Convulsion heals: ulcus cruris inflammation is complete to healing, wound wound healing.Foreskin, glans penis, glans penis inflammatory resolution, pimple disappears, and pruritus disappears.Take a turn for the better: wound ulcus cruris wound surface substantially closes or reduces.Invalid: through 2-3 week treatment without obviously changing.
Four, result
Above-mentioned treatment, reaches 83.% to ulcus cruris cure rate, and only 1 example (16.%) takes a turn for the better not yet complete to closed.Trauma infection contamination wound surface a hundred per cent more platform, reaches 100% to foreskin, glans penis inflammation and pruritus and disappears.Subordinate list is as follows:
Five, discuss
Clinical treatment shank vein inflammation being merged to ulcer is relatively stranded Huaihe River, applies medicine of the present invention treatment, and merge through outpatient service observation treatment shank vein and leak infections 6 example, 5 examples of fully recovering, 1 example is clearly better.Traumatic infection best results after treatment wound, reaches absolutely.To foreskin, balanitis, pimple, the also satisfaction of pruritus effect.Medicine of the present invention can substitute general externally used antimicrobial liquid, externally used antimicrobial element, plays and rinses clean wound surface, anticorrosion, convergence, antibacterial or antibacterial object, and can promote wound wound contraction, closed, effect of cell growth, and the side effect such as nontoxic, nothing allergy.Can large-scale popularization application.Prompting: as serious traumatic infection, ulcer merge General Symptoms person and should coordinate antibiotics Comprehensive Treatment, more can Shorten the Treatment Process.
Claims (5)
1. a wound spray Chinese herbal antibacterial liquid, is characterized in that following bulk drugs precipitate with ethanol extract is first converted 7-11 times of weight pure water and obtained water-soluble former medicine, then blends into loose square-bottomed bamboo basket acid sodium obtained; Or following bulk drugs precipitate with ethanol extract convert 7-11 times of weight dissolve in loose square-bottomed bamboo basket acid sodium pure water obtain; Or following bulk drugs precipitate with ethanol extract is first blended into a part of pure water and obtains water-soluble former medicine, to be blended in described water-soluble former medicine obtained by the loose square-bottomed bamboo basket acid sodium aqueous solution after another part pure water being blended into loose square-bottomed bamboo basket acid sodium again, the weight ratio of described precipitate with ethanol extract and described two parts pure water is 1: 7-11;
The weight ratio of pine square-bottomed bamboo basket acid sodium and described water-soluble former medicine is 1.5-3: 1000; Described crude drug weight proportion is: Herba Andrographis 50-110, Cortex Phellodendri 50-110, Radix Berberidis 40-100, Celastrus angulatus 40-100, Radix Isatidis 40-100, Radix Sophorae Flavescentis 40-100, Cortex Mori 40-80, Santonin 40-80, Aloe 40-80, Fructus Rosae Laevigatae 40-80, Caulis Akebiae 40-80, Radix Sophorae Tonkinensis 40-80, Sichuan Citrus reticuiata Blano 30-70, Radix Et Rhizoma Rhei 30-70, Rhizoma Corydalis 30-70, Radix Glycyrrhizae 30-70.
2. antimicrobial fluid according to claim 1, is characterized in that described crude drug weight proportion is: Herba Andrographis 80, Cortex Phellodendri 80, Radix Berberidis 70, Celastrus angulatus 70, Radix Isatidis 70, Radix Sophorae Flavescentis 70, Cortex Mori 60, Santonin 60, Aloe 60, cherokee rose fruit 60, Caulis Akebiae 60, Radix Sophorae Tonkinensis 60, Sichuan Citrus reticuiata Blano 50, Radix Et Rhizoma Rhei 50, Rhizoma Corydalis 50, Radix Glycyrrhizae 50.
3. antimicrobial fluid according to claim 1, is characterized in that described extract is blended into the pure water of 9 times of weight or the weight ratio of described precipitate with ethanol extract and described two parts pure water is 1: 9; The weight ratio of pine square-bottomed bamboo basket acid sodium and described water-soluble former medicine is 2: 1000.
4. antimicrobial fluid according to claims 1 or 2 or 3, is characterized in that described precipitate with ethanol extracts and in turn includes the following steps: and crude drug remove impurity-rinsing-steaming and decocting-concentrating-ol sinks-and recovery ethanol is obtained.
5. antimicrobial fluid according to claim 4, it is characterized in that described steaming and decocting be crude drug after rinsing add water steaming and decocting, filter to get filtrate, it is described that concentrated to be that described filtrate is concentrated to obtain concentrate, described precipitate with ethanol be described concentrate with 75% ethanol precipitate with ethanol 48 hours obtained precipitate with ethanol extracts.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578171A (en) * | 2012-01-11 | 2012-07-18 | 张彦斌 | Chinese herbal medicinal insecticide |
| CN102578170A (en) * | 2012-01-11 | 2012-07-18 | 蔡葵荣 | Chinese herbal medicinal bactericide |
| CN102578169A (en) * | 2012-01-11 | 2012-07-18 | 蔡葵荣 | Chinese herb biological disinfectant |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578171A (en) * | 2012-01-11 | 2012-07-18 | 张彦斌 | Chinese herbal medicinal insecticide |
| CN102578170A (en) * | 2012-01-11 | 2012-07-18 | 蔡葵荣 | Chinese herbal medicinal bactericide |
| CN102578169A (en) * | 2012-01-11 | 2012-07-18 | 蔡葵荣 | Chinese herb biological disinfectant |
Non-Patent Citations (1)
| Title |
|---|
| 刘华钢等: "中药抗菌研究进展", 《时珍国医国药》 * |
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