CN101897693B - Catechin compounds or application of plant extraction containing same and pharmaceutical composition - Google Patents
Catechin compounds or application of plant extraction containing same and pharmaceutical composition Download PDFInfo
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- CN101897693B CN101897693B CN2009100519493A CN200910051949A CN101897693B CN 101897693 B CN101897693 B CN 101897693B CN 2009100519493 A CN2009100519493 A CN 2009100519493A CN 200910051949 A CN200910051949 A CN 200910051949A CN 101897693 B CN101897693 B CN 101897693B
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Abstract
The invention discloses catechin compounds or application of plant extraction containing the same, and a pharmaceutical composition for preventing and treating the infant diaper rash. The pharmaceutical composition has remarkable bactriostasis on common pathogenic bacteria of diaper patients, can also remarkably relieve the rash symptom of a pathological change area, can promote the healing of damage and ulcer skin, and has the advantages of definite curative effect, simple and convenient use, favorable safety and the like.
Description
Technical field
The present invention relates to catechin compounds or contain the application of its plant extract, and a kind of pharmaceutical composition of preventing and treating the baby diaper rash.
Background technology
The baby diaper rash is commonly called as red buttocks, claims that also diaper dermatitis, symptom show as skin of buttock hyperemia rubescent, rash, skin injury even erosion etc.The baby uses diaper, and urine or feces can directly stimulate diaper zone skin, and not good owing to the skin of buttock breathability again simultaneously, infant skin is tender and lovely in addition, as easy as rolling off a logly brings out diaper rash.In general, the diaper rash of degree varies can appear in most of babies.
Though the baby diaper rash is medically incorporating dermatitis and eczema class cutaneous diseases into, but is different from general dermatitis and eczema.Infant is not the simple epitome of adult, with the adult a lot of differences is arranged clinically, shows kinds of Diseases, pathology, clinical manifestation and heal back various aspects and adult's different characteristics.Clinically, routine is used for the medicine of dermatitis and eczema, and is unsatisfactory to the curative effect of baby diaper rash like several types of medicines such as corticosteroids or antihistaminics.
The medicine or the care product that can clearly prevent and treat at present the baby diaper rash clinically are less; General clinical care is main embodiment with the bacterial growth (commonly used like boric acid lotion or antibiotic etc.) that suppresses diseased region, the skin (commonly used like vaseline, zinc oxide etc.) of the dry lesion region of convergence mostly, and effect is all undesirable.Part medical institutions also attempt preparing the treatment that some pharmaceutical preparatioies are used for the baby diaper rash; Relatively better (5% tannic acid ointment and 20% tannic acid ointment prevent the clinical observation of infant diaper rash, Guangdong pharmacy, Chen Xia in the therapeutic evaluation that tannic acid ointment wherein also only arranged; 2005,15 (6): 78; The preparation and the clinical practice of new tannic acid ointment, department of pediatrics pharmaceutical journal, Hu Lirong etc., 2005,11 (3): 27-28).Though tannic acid is definite relatively for the curative effect of baby diaper rash, the use of tannic acid is also dangerous, there are some researches show that (tannic acid is claimed tannin again to mouse subcutaneous injection 1.875mg/kg Gallotannin; Be mainly derived from Chinese Galla Chinensis), get blood after the administration for 3 times and record Serum ALT and significantly increase the then visible most of hepatic necrosis of liver organization form inspection and degeneration (China's book on Chinese herbal medicine; Shanghai science tech publishing house, 1999, the 5th; 3935); So tannic acid can produce histoorgan toxicity damaged, the heavy dose of use in ulcer skin place, therefore, reply uses tannic acid treatment diaper rash to hold the prudent attitude.
Catechin compounds is the general name of polyhydroxy flavane-3-phenol, mainly is made up of non-ester catechin and ester catechin.Described non-ester catechin mainly comprises catechin (C), epicatechin (EC), epigallo catechin (EGC) and gallic acid catechin (GC); Described ester catechin mainly comprises catechin and gallate (CG), L-Epicatechin gallate (ECG), epigallocatechin gallate (EGCG) (EGCG) and nutgall catechin gallic acid ester (GCG).Catechin compounds extensively is present in the natural plants; Wherein abundant with the content of catechin compounds in the Folium Camelliae sinensis; The general content that from Folium Camelliae sinensis, extracts catechin compounds in the polyphenol property material (claiming tea polyphenols again) that obtains can account for the 60%-80% of polyphenol total amount; Comprise epigallocatechin gallate (EGCG) (Epigallocatechin gallate, EGCG), L-Epicatechin gallate (Epicatechin gallate, ECG), nutgall catechin gallic acid ester (GCG), epigallo catechin (Epicatechin; EGC), epicatechin (Epigallocatechin; EC) etc., various catechin compounds shared ratio in Folium Camelliae sinensis does not wait, and wherein the content of EGCG is higher relatively.
Catechin compounds is as polynary phenoloid; Has good removing free radical function; Some research report catechin compounds also have effects such as the capillary wall of enhancing toughness, blood sugar lowering, blood cholesterol and low density lipoprotein, LDL, radioprotective and ultraviolet, mutation, also have research to show that catechin compounds has the effect of blood circulation promoting and blood stasis dispelling.At present, Shang Weijian is applied to catechin compounds the relevant report of the control of baby diaper rash.
Summary of the invention
Technical problem to be solved by this invention is for good effect being provided, using the medicine of easy and healthy and safe treatment baby diaper rash, and discloses catechin compounds or contained application and a kind of pharmaceutical composition of preventing and treating the baby diaper rash of its plant extract.
The plant extract that the invention discloses catechin compounds or contain it is in the medicine of preparation control baby diaper rash or the application in the care product.
Wherein, described catechin compounds can be the mixture of catechin compounds, also can be single catechin compounds, preferred epigallocatechin gallate (EGCG) (EGCG).Described catechin compounds such as catechin (C), epicatechin (EC), epigallo catechin (EGC), gallic acid catechin (GC), catechin and gallate (CG), L-Epicatechin gallate (ECG), epigallocatechin gallate (EGCG) (EGCG) or nutgall catechin gallic acid ester (GCG).Among the present invention, described catechin compounds can be by synthetic, the bullion or the pure article that also can from natural plants (preferred Folium Camelliae sinensis), make according to existing method extraction separation.The described plant extract that contains catechin compounds is preferable is tea extract, and better is tea polyphenols.
Among the present invention, described care product is meant conventional sanitary care article, the non-medicinal products such as diaper that refer generally to hip pad cream for baby, perhaps have certain drug effect.
The invention still further relates to a kind of pharmaceutical composition of preventing and treating the baby diaper rash, the plant extract that it comprises catechin compounds and/or contains catechin compounds.
Wherein, described catechin compounds or the content of plant extract in pharmaceutical composition that contains catechin compounds are at least medicine effective quantity, and that preferable is 0.5-50%, and percentage ratio is mass percent.Described catechin compounds or the plant extract that contains catechin compounds are with aforementioned.
What pharmaceutical composition of the present invention was preferable is external preparation, like cream, ointment, spray, gel, liniment, patch or liniment etc.According to its dosage form, pharmaceutical composition of the present invention can be used the conventional adjuvant of various pharmaceutical fields, comprises in excipient, transdermal agent and the pruritus one or more.Described excipient is the conventional adjuvant in this area, one or more that preferable is in liquid Paraffin, glyceryl monostearate, stearic acid, polyvinyl alcohol, carbomer and the carboxymethyl cellulose.Described transdermal agent is the conventional adjuvant in this area, and in order to promote skin absorbs, preferable is sodium lauryl sulphate and/or azone.Described pruritus is the conventional adjuvant in this area, and preferable is Oleum menthae and/or Borneolum Syntheticum.Except that above-mentioned adjuvant, pharmaceutical composition of the present invention also can contain other be used to prevent and treat the baby diaper rash active constituents of medicine, use as compound preparation.
Pharmaceutical composition of the present invention can make by the method for this area conventional dose preparation.The concrete using dosage of pharmaceutical composition can be adjusted according to the practical situations such as the order of severity of dosage form, disease, but one or many medication every day.
Agents useful for same of the present invention and raw material are all commercially available to be got.
Positive progressive effect of the present invention is: the invention discloses catechin compounds or contain application and a kind of pharmaceutical composition of preventing and treating the baby diaper rash of the plant extract of catechin compounds.This pharmaceutical composition has remarkable bacteriostasis to diaper rash patient common pathogenic bacteria; Can obviously alleviate simultaneously the erythra symptom of lesion region; And can promote the healing of breakage, ulcer skin, the multiple advantage of have determined curative effect, use is easy and healthy, safety is good etc.
The specific embodiment
Mode through embodiment further specifies the present invention below, but does not therefore limit the present invention among the described scope of embodiments.
Effect embodiment 1
Adopt agar diffusion method, specimen I (self-control green tea extract, wherein catechin compounds content is 60%), sample II (tea polyphenols; Wherein catechin compounds content is 87.1%, and EGCG content is 62.6%, available from Zhejiang one new pharmaceutical Co. Ltd; Lot number 080614), sample III (EGCG; Purity 97.2% is available from Zhejiang one new pharmaceutical Co. Ltd, lot number 080530) bacteriostatic activity.
Self-control green tea extract method: get Folium Camelliae sinensis, decocte with water secondary, merging filtrate; Filtrate after concentrated slightly and the cooling, add saturated limewater adjust pH to 9, leave standstill; Filter, get filtering residue and slowly add diluted hydrochloric acid dissolution and adjust pH to 4, filter; Filtrating is with ethyl acetate extraction, decompression and solvent recovery, and cold drying promptly gets.
Above each sample is mixed with 5% concentration solution with aseptic double-distilled water, crosses aseptic filter membrane, subsequent use.Bacterial classification inoculations such as depletion Staphylococcus aureus, escherichia coli, Hong Se Mao Xian bacterium, Candida albicans are in nutrient broth; Cultivate 18h for 37 ℃; Dip in to get with the sterilization cotton swab and supply examination bacterium liquid, evenly coat on the nutrient agar panel, the Gelose punch with diameter 6mm evenly punches then; Remove in the hole at the bottom of agar and the suitable blind hole in every plate 6 holes.Each sample solution is added in the hole, is advisable and performs labelling with full without flowing over, simultaneously with aseptic double-distilled water as blank.The effect of putting in 4 ℃ of refrigerators is taken out after 1 hour and is placed 37 ℃ of calorstats to cultivate observed result 24 hours.
Criterion: antibacterial circle diameter is bacteriostatic activity and is positive greater than 10mm.
The bacteriostatic test result sees table 1:
Table 1 sample is to the bacteriostatic test of different bacterium
Annotate: "-" shows antibacterial feminine gender; "+" shows the antibacterial positive.
Conclusion: sample I, II, III all have certain bacteriostatic activity to each pathogen.
Effect embodiment 2
Sample thief I (self-control green tea extract, wherein catechin compounds content is 60%), sample II (tea polyphenols, wherein catechin compounds content is 87.1%; EGCG content is 62.6%, available from Zhejiang one new pharmaceutical Co. Ltd, lot number 080614), sample III (EGCG; Purity 97.2% is available from Zhejiang one new pharmaceutical Co. Ltd, lot number 080530); It is 15% cream that each sample is mixed with mass percentage content respectively, subsequent use.
Wherein, the method for preparing of cream is: 1. sample 20g, and 2. hexadecanol 76.5g, 3. vaseline 150g, 4. liquid paraffin 60g, 5. sodium lauryl sulphate 8.5g, 6. propylene glycol 50g, 7. ethyl hydroxybenzoate 1g, the aseptic double-distilled water that 8. newly boils is some.Earlier will be 2. 3. 4. in water-bath fusion get solution A, will 5. 6. 7. adding the distilled water heating for dissolving gets solution B, will 1. inject solution B and get solution C with an amount of distilled water dissolving back, solution A added gradually be stirred to emulsifying in the solution C, cooling gets final product.
Treat 12 routine diaper dermatitis infants (age is 18 days--1 years old), anal skin redness person 9 examples wherein, slight damaged 3 examples of skin, the extent of disease minimum is 3cm * 5cm, maximum area is 7.5cm * 9.5cm.During each changing babies' napkin, with wet tissue skin of buttock is softly cleaned earlier, be coated with equably then and spread various kinds article cream.
The result: each medication therapy groups, fully recovered basically in the infant 1-2 of red swelling of the skin days, fully recovered basically in infant 3-6 days of the slight breakage of skin.
Claims (3)
1. a catechin compounds is prevented and treated the medicine of baby diaper rash or the application in the care product as unique active component in preparation.
2. application as claimed in claim 1 is characterized in that: described catechin compounds is the mixture of catechin compounds, or single catechin compounds.
3. application as claimed in claim 2 is characterized in that: described catechin compounds is catechin, epicatechin, epigallo catechin, gallic acid catechin, catechin and gallate, L-Epicatechin gallate, epigallocatechin gallate (EGCG) or nutgall catechin gallic acid ester.
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| CN2009100519493A CN101897693B (en) | 2009-05-26 | 2009-05-26 | Catechin compounds or application of plant extraction containing same and pharmaceutical composition |
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| CN2009100519493A CN101897693B (en) | 2009-05-26 | 2009-05-26 | Catechin compounds or application of plant extraction containing same and pharmaceutical composition |
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| Publication Number | Publication Date |
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| CN101897693A CN101897693A (en) | 2010-12-01 |
| CN101897693B true CN101897693B (en) | 2012-08-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735367A (en) * | 2013-12-17 | 2014-04-23 | 张月婵 | Sanitary towel containing catechinic acid |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110907A (en) * | 2012-12-11 | 2013-05-22 | 余金标 | Ointment for treating baby diaper dermatitis |
| CN110151752B (en) * | 2019-06-03 | 2021-12-31 | 湖北省农业科学院畜牧兽医研究所 | Tea polyphenol composition and application thereof in preparation of anti-streptococcus suis medicines |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200994863Y (en) * | 2006-09-18 | 2007-12-26 | 曹维 | Health-care paper pants containing tea-seed essence |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200994863Y (en) * | 2006-09-18 | 2007-12-26 | 曹维 | Health-care paper pants containing tea-seed essence |
Non-Patent Citations (4)
| Title |
|---|
| 刘庆翠，等.新生儿臀红症(尿布疹)防治方法的探讨.《中国妇幼保健》.2005,第20卷(第23期),3110-3111. * |
| 徐小玲,等.绿茶水防治婴幼儿尿布疹的护理体会.《山西医药杂志》.2007,第36卷(第4期),379-380. * |
| 李叶云，等.茶多酚的生物活性及药理学研究进展.《安徽中医学院学报》.2002,第21卷(第5期),57-60. * |
| 贾玉双,等.新生儿尿布疹与局部感染菌群相关性研究.《护理研究》.2002,第16卷(第3期),156-157. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735367A (en) * | 2013-12-17 | 2014-04-23 | 张月婵 | Sanitary towel containing catechinic acid |
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| CN101897693A (en) | 2010-12-01 |
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