CN111514119A - Adhesive bandage containing industrial hemp root extract and preparation method thereof - Google Patents
Adhesive bandage containing industrial hemp root extract and preparation method thereof Download PDFInfo
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- CN111514119A CN111514119A CN202010458658.2A CN202010458658A CN111514119A CN 111514119 A CN111514119 A CN 111514119A CN 202010458658 A CN202010458658 A CN 202010458658A CN 111514119 A CN111514119 A CN 111514119A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Abstract
The invention discloses a band-aid containing industrial hemp root extract and a preparation method thereof, and the band-aid comprises the steps of pretreatment, crushing, extraction, concentration, water precipitation, filtration, paste preparation, compatibility, medicine moistening, drying and band-aid of industrial hemp roots.
Description
Technical Field
The invention relates to medicine, in particular to a wound plaster containing industrial hemp root extract and a preparation method thereof.
Background
Industrial hemp is also called as hemp, and the whole body of hemp is treasure and has three main functions of textile, edible and medicinal. There are several tens of known compounds isolated from roots of industrial cannabis sativa, including industrial cannabinoids (canabisavine), dehydrated industrial cannabinoids (anhyrocanabisavine), choline (choline), neurone (neurone), friedelin (friedelin), epifriedelinol (epifriedelinol), carvone (carvone), dihydrocarvone (dihydrocarvone), β -sitosterol (β -sitosterol) [4], industrial cannabicycloether terpene (cannagendal), further including various fatty acids and 5 α -ergosta-3-one, 5 α -stigmast-3-one (5 α -stigmasta-3-one), campesterol (campesterol), stigmasterol (stigmasterol), 5 β -stigmast-22-en-3-one (5 α -stigmast-22-3-one) [ 6-stigmast-4-3-one ], 5 α -stigmast-3-one (5 α -stigmast-3-one), campest-4-en-3-one (campest-4-en-3-one), stigmast-4,22-dien-3-one (stigmast-4,22-dien-3-one), stigmast-5-en-3 β -ol-7-one, campest-5-en-3 β -ol-7-one (campest-5-en-3 β -ol-7-one), stigmast-5, 22-en-3 β -ol-7-one (stigmast-5, 22-dien-3 β -ol-7-one), etc., which have the effects of removing blood stasis, stopping bleeding, inducing diuresis, etc. in medicine.
People are difficult to avoid collision in daily life and work, and traumatic bleeding is the most common trauma injury which is not excessive; is not limited to
The wound is cleaned in time and the hemostasis often causes great injury to the wounded, once the wound is polluted, the wound can be suppurated, septicemia, tetanus or bacterial infection, great inconvenience is brought to subsequent treatment, the existing sterilization hemostasis medicines of the emergency department are chemical synthesis products, the sterilization hemostasis medicine has the advantages of thorough sterilization, rapid hemostasis and the like, but has sensitization, injury causing property and irritation simultaneously, once the patient has anaphylactic reaction or reaction generation accelerating wound deterioration, the wound hemostasis medicine can cause great injury to the patient.
Disclosure of Invention
In order to solve the problems, the invention provides a wound plaster containing industrial hemp root extract and a preparation method thereof, which have the advantages of convenient use, water resistance, good air permeability, no anaphylactic reaction, no drug resistance and the like.
The technical scheme of the invention is as follows:
a wound plaster containing industrial hemp root extract comprises the following components:
60-100 parts of industrial hemp root extract, 15-25 parts of cuttle bone, 5-15 parts of folium artemisiae argyi, 5-15 parts of baked ginger, 8-15 parts of garden burnet root and 5-15 parts of lalang grass rhizome.
A preparation method of a wound plaster containing industrial hemp root extract comprises the following steps:
(1) pre-treating, namely taking a certain amount of industrial hemp root, cleaning, putting into a drying oven for drying, setting the drying temperature at 100 ℃ and 120 ℃, and drying until the water content is lower than 10%.
(2) Pulverizing, the dried industrial hemp root is pulverized into 20-40 mesh particles.
(3) Extracting by putting the crushed industrial hemp grains into an extraction kettle, adding 2-5 times of ethanol solution, and extracting for 2-4 times, wherein the ethanol solution is 60-80%.
(4) And (3) concentrating, namely combining the extracting solutions obtained in the step (3), and concentrating under reduced pressure to 1/3 volumes to obtain the industrial hemp root concentrated solution.
(5) And (4) water precipitation, namely adding 2 times of deionized water into the industrial hemp root concentrated solution obtained in the step (4), stirring uniformly and standing for 18-24 hours.
(6) Filtering, namely taking the supernatant obtained in the step 5, and filtering by using a 600-800-mesh filter screen.
(7) And (3) preparing paste, namely transferring the filtrate obtained in the step (6) into a concentration kettle, and concentrating under reduced pressure until the relative density is 1.8, wherein the concentration temperature is 70-85 ℃.
(8) The compatibility is that 60-100 parts of industrial hemp root extract, 15-25 parts of cuttle bone, 5-15 parts of Chinese mugwort leaf, 5-15 parts of baked ginger, 8-15 parts of garden burnet root and 5-15 parts of cogongrass flower are weighed, decocted for two times, each time lasts for 1h, decoction liquid is merged, filtered and concentrated to 150 plus 200 ml.
(9) Moistening the drugs: and (4) putting the gauze of the wound plaster into the mixed liquid medicine obtained in the step (8) to be soaked for 20-40 minutes, taking out and placing on a filter screen.
(10) And (3) drying, namely when the soaked sliver has no liquid drops, putting the sliver into a vacuum drying oven for drying, wherein the drying temperature is set to be 30-55 ℃, the vacuum degree is less than-0.06 MPa, and the drying time is 36-48 h.
(11) And (3) preparing a patch, namely sticking the drug-containing yarn strip prepared in the step (10) on an adhesive tape, and packaging to obtain the adhesive patch containing the industrial cannabis sativa extract.
The medicine of the invention has the following functions:
industrial hemp root
Nature, flavor and meridian tropism: bitter; the nature is mild.
The efficacy is as follows: is root of industrial hemp of Moraceae. Can be used for treating gonorrhea, metrorrhagia, leukorrhagia, dystocia, retained afterbirth, and traumatic injury.
The main treatment is as follows: dispel blood stasis, stop bleeding and induce diuresis. It is mainly indicated for gonorrhea, metrorrhagia, leukorrhagia, dystocia, retained afterbirth, traumatic injury.
Cuttlefish bone
Salty, astringent and slightly warm in nature and flavor entering meridians. Enter liver and kidney meridians.
Has the functions of astringing to stop bleeding, arresting seminal emission, stopping leukorrhagia, relieving hyperacidity and pain, promoting granulation and eliminating dampness.
Folium Artemisiae Argyi
Nature, flavor and meridian tropism: bitter, pungent and warm. It enters liver, spleen and kidney meridians.
The efficacy is as follows: warm meridians to stop bleeding, dispel cold to alleviate pain.
The main treatment is as follows: can be used for treating hematemesis, epistaxis, metrorrhagia, metrostaxis, abdominal psychroalgia, and abdominal pain during menstruation.
Baked ginger
Nature, flavor and meridian tropism: bitter, astringent and warm. It enters spleen and liver meridians.
The efficacy is as follows: warm meridians to stop bleeding, warm middle energizer to alleviate pain.
The function of the baked ginger is as follows: 1. bleeding, abdominal pain, diarrhea, 2.
Radix Sanguisorbae
Nature, flavor and meridian tropism: bitter, sour, slightly cold; it enters liver, stomach and large intestine meridians.
The efficacy is as follows: cool blood to stop bleeding, remove toxicity and heal wound.
The main treatment is as follows: can be used for treating hematemesis, epistaxis, hematochezia, metrorrhagia, scald, and eczema.
Flos Imperatae
Nature, flavor and meridian tropism: sweet, warm and nontoxic; enter lung and liver meridians.
The main treatment is as follows: promoting blood circulation to stop bleeding, removing blood stasis to relieve pain, stopping bleeding and healing wound. It is indicated for hematemesis, epistaxis and knife wound.
The invention utilizes the compatibility principle of the traditional Chinese medicine: the medicines of industrial hemp root, garden burnet root and cuttle bone interact with each other to stop bleeding and cool blood at the same time, so that red swelling and hot pain around the wound can be quickly eliminated as monarch medicine; the folium artemisiae argyi, the flos imperatae and the two medicines have the effects of removing blood stasis and stopping bleeding, can enhance the hemostasis effect of monarch medicines, can stop bleeding without retaining blood stasis, and simultaneously has the functions of concurrently stopping bleeding and removing blood stasis, can clear away heat and toxic materials, warm channel and relieve pain as ministerial medicines, and the baked ginger can warm channel and stop bleeding and relieve pain; meanwhile, the medicines have the effect of drying dampness, can clean wounds to dispel analytes of the wounds, and further enhance the sterilization effect.
The invention utilizes traditional Chinese medicine raw materials with the effects of stopping bleeding, sterilizing, diminishing inflammation and relieving pain, has reasonable proportion, has good effects of stopping bleeding, clearing away heat and toxic materials, diminishing inflammation and swelling, promoting blood circulation by removing blood stasis, removing putrefaction and promoting tissue regeneration when treating wounds, can effectively control the growth and reproduction of infectious pathogenic bacteria, simultaneously improves the microcirculation around the wound surface, increases the local blood flow, promotes the growth of granulation tissues and accelerates the healing.
Detailed Description
The technical solution of the present invention will be further described with reference to the following examples.
Example 1
A preparation method of a wound plaster containing industrial hemp root extract comprises the following steps:
(1) the pretreatment comprises cleaning 50kg industrial hemp root, drying in a drying oven at 110 deg.C for 20 hr, taking out, and measuring water content to obtain 8%.
(2) Pulverizing, namely putting the dried industrial hemp root into a pulverizer to be pulverized into 40-mesh particles.
(3) Extracting by putting the crushed industrial hemp grains into an extraction kettle, adding 5 times of 80% ethanol solution, and extracting for 3 times.
(4) And (3) concentrating, namely combining the extracting solutions obtained in the step (3), placing the extracting solutions in a reduced pressure concentration kettle, concentrating at the temperature of 75 ℃ under the pressure of-0.06 MPa, and concentrating under reduced pressure to 1/3 volumes to obtain the industrial hemp root concentrated solution.
(5) And (4) water precipitation, namely adding 2 times of deionized water into the industrial hemp root concentrated solution obtained in the step (4), stirring uniformly and standing for 24 hours.
(6) And (5) filtering, namely taking the supernatant obtained in the step (5), and performing pressure filtration by using a 800-mesh filter screen.
(7) And (3) preparing paste, namely transferring the filtrate obtained in the step (6) into a concentration kettle, and concentrating under reduced pressure until the relative density is 1.8, wherein the concentration temperature is 75 ℃.
(8) The compatibility is that 60g of industrial hemp root extract, 18g of cuttle bone, 11g of argy wormwood leaf, 9g of baked ginger, 9g of garden burnet root and 8g of lalang grass rhizome are weighed, decocted twice for 1h each time, the decoction is combined, filtered and concentrated to 180 ml.
(9) Moistening the drugs: and (4) putting the gauze of the wound plaster into the mixed liquid medicine obtained in the step (8) for soaking for 30 minutes, taking out and placing on a filter screen.
(10) And (3) drying, namely when the soaked sliver has no liquid drops, putting the sliver into a vacuum drying box for drying, wherein the drying temperature is set to be 45 ℃, the vacuum degree is less than-0.06 MPa, and the drying time is 48 h.
(11) And (3) preparing a patch, namely sticking the drug-containing yarn strip prepared in the step (10) on an adhesive tape, and packaging to obtain the adhesive patch containing the industrial cannabis sativa extract.
The curative effect evaluation in vitro antibacterial experiment of the invention:
1. the experimental strains are staphylococcus aureus, pseudomonas aeruginosa and escherichia coli.
2. The strain culture medium comprises nutrient agar culture medium and low serum culture medium.
3. The bacteriostasis experiment comprises an experiment group and a control group, wherein the experiment group is the sterilization and hemostasis medicine in the embodiment 3 of the invention, and the control group is selected from 1: 1000 of chlorhexidine disinfection solution.
4. Specific experimental procedures
(1) Preparing bacterial liquid, inoculating the two groups of strains on two agar culture media respectively, culturing at 37 ℃ for 32 hours, selecting typical bacterial colonies from the two groups of strains, inoculating the typical bacterial colonies in two low serum culture media respectively, and culturing at the same temperature for 24 hours for later use.
(2) Respectively taking the concentrated solution obtained in the step 8 in the embodiment 1 of the invention and 1: 1000 portions of chlorhexidine disinfection solution, i 00ml, are respectively placed in a dilution container, and diluted by 10 times, and the two dilution solutions are respectively placed in two containers and placed under aseptic condition for standby.
(3) Respectively diluting the experimental strains cultured for 24 hours in the step (1) by 20 times by using sterile low serum, and respectively packaging each strain in two culture dishes to respectively mark a control group and an experimental group.
(4) The diluted solution of the concentrated solution obtained in the step 8 of the present invention in the example 1 obtained in the above step (2) was dropped into a petri dish of experimental group, 1: 1000 diluted chlorhexidine solution was dropped into the control petri dish.
5. Experimental observation and measurement
The above experiments were observed and the area of the residual strain was measured, and the specific results are shown in the following table.
6. After observation and measurement are finished, the culture dishes are placed under the aseptic condition and are kept stand for three days, tracking and observation show that the colony change of a control group is small, and the colony of an experimental group is unchanged.
7. Results of the experiment
The bactericidal capacity of the experimental group is equivalent to that of the control group, and the continuous propagation of the strains can be inhibited.
Evaluation of clinical efficacy
The invention is used for treating patients with knife wound and bruise, and the clinical curative effect observation experiment is as follows:
first, evaluation of curative effect
Remarkably: the pus and blood in the incision and the wound are collected and flow out, the incision and the wound are not red and swollen any more, and the incision and the wound are healed within 1-2 days.
Improvement: the pus and blood in the incision and the wound are collected and flow out, the incision and the wound are not red and swollen any more, and the incision and the wound are healed for 2 to 3 days.
And (4) invalidation: some pus and blood were retained in the incision and the site of abrasion, which did not heal completely within 5 days.
Second, therapeutic methods
The wounds were cleaned with absorbent cotton, iodine tincture and hydrogen peroxide, and then the traditional Chinese medicine wound plaster of the invention example 1 was applied to the incisions and the wounds, and the dressing change was performed once every 1 day.
Third, observation of treatment
50 blunt-scratched patients and 50 scratched patients were searched. The wound dressings prepared in example 1 were individually distributed to experimenters for trial use.
The test person takes the adhesive bandage and sticks it on the wounded part, and changes it once every day, and continuously tests for 2 days. The test results are shown in the table below.
It can be seen from the table that the total effective rate of the invention for the blunt trauma patient and the bruise wound healing is more than 90%.
The traditional Chinese medicine wound plaster has no toxic or side effect, has definite curative effect, has special effects of stopping bleeding, stopping pain and the like, and has the effects of counteracting toxic substances, healing sore, removing necrotic tissue and promoting granulation on infected wounds.
The above examples are merely illustrative of the present invention and do not limit the scope of the present invention in any way. It will be apparent to those skilled in the art that equivalent embodiments or modifications without departing from the technical spirit of the present invention are within the scope of the present invention.
Claims (9)
1. A wound dressing containing industrial cannabis sativa root extract is characterized in that the content of tetrahydrocannabinol is not detected.
2. The wound covering containing industrial cannabis sativa root extract as claimed in claim 1, wherein the ratio of the drugs is: 60-100 parts of industrial hemp root extract, 15-25 parts of cuttle bone, 5-15 parts of folium artemisiae argyi, 5-15 parts of baked ginger, 8-15 parts of garden burnet root and 5-15 parts of lalang grass rhizome.
3. The wound covering containing the industrial cannabis sativa root extract and the preparation method thereof as claimed in claim 1, wherein the wound covering containing the industrial cannabis sativa root extract and the preparation method thereof are as follows:
(1) pre-treating, namely taking a certain amount of industrial hemp root, cleaning, and drying in a drying oven;
(2) pulverizing dried industrial radix Cannabis to 20-40 mesh particles;
(3) extracting, namely putting the crushed industrial hemp particles into an extraction kettle, and adding a certain amount of ethanol solution for extraction;
(4) concentrating, namely combining the extracting solutions obtained in the step 3, and concentrating under reduced pressure to 1/3 volumes to obtain an industrial hemp root concentrated solution;
(5) water precipitation, namely adding a certain amount of deionized water into the industrial hemp root concentrated solution obtained in the step 4, stirring uniformly and standing;
(6) filtering, namely filtering the supernatant in the step 5 by using a filter press;
(7) c, preparing paste, namely transferring the filtrate obtained in the step 6 into a concentration kettle, and concentrating under reduced pressure to obtain industrial hemp root extract paste;
(8) the compatibility is that 60-100 parts of industrial hemp root extract, 15-25 parts of cuttle bone, 5-15 parts of Chinese mugwort leaf, 5-15 parts of baked ginger, 8-15 parts of garden burnet and 5-15 parts of cogongrass flower are weighed, decocted for two times, each time lasts for 1h, decoction liquid is merged and filtered, and the decoction liquid is concentrated to 150 plus 200 ml;
(9) moistening the drugs: putting the gauze of the wound plaster into the mixed liquid medicine obtained in the step 8, soaking for 20-40 minutes, taking out and placing on a filter screen;
(10) drying, namely putting the sliver into a vacuum drying box for drying when no liquid drops drop from the soaked sliver;
(11) and (3) preparing a patch, namely sticking the drug-containing yarn strip prepared in the step (10) on an adhesive tape, and packaging to obtain the adhesive patch containing the industrial cannabis sativa extract.
4. The wound dressing containing industrial cannabis sativa root extract and the preparation method thereof as claimed in claim 3, wherein the drying temperature in step (1) is 100 ℃ and 120 ℃, and the drying is carried out until the moisture content is lower than 10%.
5. The wound covering patch containing industrial cannabis sativa root extract as claimed in claim 3, wherein ethanol is added in an amount of 2-5 times of the amount of the industrial cannabis sativa root particles in step (3) for 2-4 times, and the ethanol solution is 60-80%.
6. The wound covering patch containing the industrial cannabis sativa root extract and the preparation method thereof as claimed in claim 3, wherein the deionized water is added in an amount of 2 times of the industrial cannabis sativa root concentrate in step (5), and is stirred and left for 18-24 hours.
7. The wound dressing containing industrial cannabis sativa root extract and the preparation method thereof as claimed in claim 3, wherein the filtering screen in step (6) is 600-800 mesh.
8. The wound covering patch containing industrial cannabis sativa extract as claimed in claim 3, wherein the concentration in step (7) is performed at a relative density of 1.8 and a concentration temperature of 70-85 ℃.
9. A wound covering containing industrial cannabis sativa root extract and a preparation method thereof as claimed in claim 3, characterized in that in step (10), the drying temperature is 30-55 ℃, the vacuum degree is less than-0.06 MPa, and the drying time is 36-48 h.
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| CN202010458658.2A CN111514119A (en) | 2020-05-27 | 2020-05-27 | Adhesive bandage containing industrial hemp root extract and preparation method thereof |
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| CN202010458658.2A CN111514119A (en) | 2020-05-27 | 2020-05-27 | Adhesive bandage containing industrial hemp root extract and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991604A (en) * | 2020-08-30 | 2020-11-27 | 云南古润生物科技有限责任公司 | Adhesive bandage based on cannabidiol and manufacturing method thereof |
-
2020
- 2020-05-27 CN CN202010458658.2A patent/CN111514119A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991604A (en) * | 2020-08-30 | 2020-11-27 | 云南古润生物科技有限责任公司 | Adhesive bandage based on cannabidiol and manufacturing method thereof |
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Application publication date: 20200811 |