CN109125424B - Film coating agent for preventing and treating cow mastitis and preparation method thereof - Google Patents
Film coating agent for preventing and treating cow mastitis and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a film coating agent for preventing and treating cow mastitis and a preparation method thereof, and the film coating agent for preventing and treating cow mastitis comprises the following components: 20-50 g of rhubarb; 10-30 g of sunset abelmoschus flowers; 10-30 g of safflower; 10-30 g of myrobalan; 5-20 g of borneol; 0.1-2 g of laurocapram; 0.1-3 g of film forming agent; adding the solvent to 100 ml; a preparation method of a film coating agent for preventing and treating cow mastitis comprises the following steps: 1) putting the medicinal materials into a container according to the formula amount, and extracting by adopting a heating reflux extraction method to prepare a traditional Chinese medicine concentrated extract; 2) dissolving film-forming agent in solvent, adding Borneolum Syntheticum, laurocapram, film-forming agent and the above concentrated extractive solution of Chinese medicinal materials. The invention has the advantages that the film coating agent for preventing and treating the cow mastitis has the effects of clearing away heat and toxic materials, promoting blood circulation through dysmenorrhea, relieving swelling and pain and the like due to the synergistic effect of the medicinal materials, and the cure rate of the cow mastitis reaches more than 80%.
Description
Technical Field
The invention relates to the field of externally applied medicaments for dairy cow breasts, in particular to a film coating agent for preventing and treating dairy cow mastitis and a preparation method thereof.
Background
The cow mastitis is one of the diseases with high cow incidence and large harm loss, the incidence rate of the cow mastitis in China is 20-70%, the cow mastitis accounts for 21-23% of the total incidence rate of the cow, and a large amount of economic loss is caused every year. Among the factors causing the mastitis of the dairy cows, biological factors account for a large proportion, and pathogenic bacteria such as escherichia coli, staphylococcus aureus, streptococcus and the like easily pass through the breasts of the dairy cows due to the characteristics of the dairy cows in breeding industry to cause the mastitis of the dairy cows. At present, antibiotics are generally used for treating cow mastitis in China, but the treatment effect is not ideal along with the increase of the drug resistance of the antibiotics, and in addition, the long-term use of a large amount of antibiotics is easy to generate drug resistance of the antibiotics and also easy to form drug residues.
Disclosure of Invention
The purpose of the invention is as follows: aiming at the problems, the invention aims to provide a film coating agent for preventing and treating cow mastitis and a preparation method thereof, so as to solve the technical problem of unsatisfactory treatment effect.
The technical scheme is as follows:
a film coating agent for preventing and treating cow mastitis comprises the following components:
in one embodiment, the skin care agent further comprises 1-10 g of skin care agent.
In one embodiment, the skin care agent is at least one of propylene glycol, glycerin, dibutyl phthalate, and lanolin.
In one embodiment, the film forming agent is at least one of polyvinyl alcohol, polyvinyl butyral, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, chitosan, poloxamers, and carbomers.
In one embodiment, the solvent is at least one of ethanol and water.
The rhubarb is bitter in taste and cold in nature, and has the effects of purging and eliminating accumulation, clearing heat and purging fire, cooling blood and removing toxicity, removing blood stasis and stimulating the menstrual flow, and promoting diuresis and removing jaundice; the emodin has the effects of resisting inflammation, bacteria, viruses, fungi and protozoa, has broad-spectrum antibacterial effect, is not easy to generate drug resistance to staphylococcus aureus, is sensitive to streptococcus, is effective to diphtheria, hay bacillus, anthrax, paratyphoid fever, dysentery, bacillus influenzae, pneumococcus and catacoccus, and has strong inhibition effect on anaerobic bacteria.
Flos Abelmoschi Manihot contains quercetin-3-robinin (quercetin-3-robinoside), quercetin-3-glucoside (quercetin-3-glucoside), hyperoside (hyperin), myricetin (myricetin) and quercetin (quercetin). Sweet and pungent in flavor and cool in nature, and has the functions of promoting urination, treating stranguria, promoting blood circulation, stopping bleeding, relieving swelling and detoxifying.
The safflower is pungent and warm, contains haematochrome and uranidin, and has the effects of stimulating the menstrual flow and activating blood; carthami flos contains carthamin and safflower yellow. The fat oil is called safflower oil, and is oil and fat such as palmitic acid, stearic acid, arachidic acid, linoleic acid, linolenic acid, oleic acid and the like.
Myrobalan with a characteristic flavor and meridian tropism: flattening; bitter, sour and astringent, has astringent and antibacterial effects, is effective on various dysentery bacilli, also has strong effects on Pseudomonas aeruginosa and diphtheria bacilli, and also has effects on Staphylococcus aureus, Escherichia coli, pneumococcus, hemolytic streptococcus, Proteus vulgaris and Salmonella typhimurium (paper sheet method); the ethanol extract has higher antibacterial and antifungal effects; modern pharmacological research proves that the myrobalan contains more tannin and has strong astringent and antidiarrheal effects; the water decoction has antibacterial effect on Bacillus dysenteriae, and also has inhibitory effect on Pseudomonas aeruginosa, diphtheria bacillus, Staphylococcus aureus, Escherichia coli, pneumococcus, hemolytic streptococcus, Bacillus proteus, etc.; terminalia chebula extract extracted from dried fruit with 80% ethanol has effects of promoting bile secretion, lowering blood pressure and inhibiting smooth muscle.
Borneol is pungent, bitter and slightly cold in flavor; heart, liver and lung meridians entered; it also has the actions of clearing heat and removing toxicity, relieving swelling and pain, preventing putrefaction and promoting granulation.
A preparation method of a film coating agent for preventing and treating cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan to 10-30 meshes, putting the medicinal materials into a container according to a formula amount, adding an extraction solvent, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 3-6: 1, extracting by adopting a heating reflux extraction method for 2-3 times, mixing all extracting solutions, filtering, concentrating to prepare a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.2-1.3, wherein the volume unit of an extracting solvent is ml, and the total mass unit of medicinal materials is g;
2) dissolving the film forming agent in 40-50 ml of solvent, adding borneol, laurocapram, the film forming agent and the traditional Chinese medicine concentrated extract into the solvent, then adding the solvent to 100ml, and uniformly stirring to obtain the film coating agent for preventing and treating the mastitis of the dairy cows.
In one embodiment, the step 2) further comprises 1-10 g of a skin care agent, and the skin care agent, borneol, laurocapram, a film forming agent and the traditional Chinese medicine concentrated extract are added into the solvent.
In one embodiment, the solvent is at least one of ethanol and water.
In one embodiment, the film forming agent is at least one of polyvinyl alcohol, polyvinyl butyral, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, chitosan, poloxamers, and carbomers.
Has the advantages that: compared with the prior art, the invention has the advantages that:
1) the film coating agent for preventing and treating the mastitis of the dairy cattle is prepared by mixing rhubarb, abelmoschus manihot, safflower, myrobalan, borneol, laurocapram and a film forming agent, belongs to a pure traditional Chinese medicine preparation, has the effects of clearing heat and removing toxicity, relieving dysmenorrhea and activating blood, relieving swelling and pain, promoting granulation and the like due to the mutual synergistic effect of the medicinal materials, can kill main pathogenic bacteria of the mastitis of the dairy cattle, such as escherichia coli, staphylococcus aureus, streptococcus agalactiae, streptococcus dysgalactiae and the like, has the cure rate of the mastitis of the dairy cattle of more than 80 percent, achieves a better treatment effect, has no toxic or side effect, and can achieve a certain prevention and treatment effect on the mastitis of the dairy cattle.
2) According to the preparation method of the film coating agent for preventing and treating cow mastitis, the effective components of the rhubarb, the flower of abelmoschus manihot, the safflower and the myrobalan are advanced, the extracting solution is concentrated, the main active components of the medicinal materials can be effectively reserved, and then the film coating agent for preventing and treating cow mastitis can be obtained by mixing with other components such as borneol.
Detailed Description
Example 1
A film coating agent for preventing and treating cow mastitis comprises the following components:
in this example, the solvent is water.
The preparation method of the film coating agent for preventing and treating the cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan into 30 meshes, putting the medicinal materials into a container according to the formula amount, adding extraction solvent water, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 6: 1, adding 600ml of water into 100g of medicinal materials, extracting by a heating reflux extraction method for 2 times, mixing all extracting solutions, filtering, concentrating to obtain a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.2;
2) dissolving the film forming agent in 50ml of solvent, adding borneol, laurocapram, polyvinyl alcohol and the concentrated extract of the traditional Chinese medicines into the solvent, and then adding the solvent to 100ml to obtain the film forming agent for preventing and treating the mastitis of the dairy cows.
Example 2
A film coating agent for preventing and treating cow mastitis comprises the following components:
in this example, the solvent is water.
The preparation method of the film coating agent for preventing and treating the cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan into 10 meshes, putting the medicinal materials into a container according to the formula amount, adding extraction solvent water, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 6: 1, namely 600ml of water, extracting by a heating reflux extraction method for 2 times, mixing all extracting solutions, filtering, concentrating and preparing a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.2;
2) dissolving the film forming agent in 40ml of solvent, adding borneol, laurocapram, glycerol, polyvinyl alcohol and the traditional Chinese medicine concentrated extract into the solvent, and then adding the solvent to 100ml to obtain the film forming agent for preventing and treating the mastitis of the dairy cows.
Example 3
A film coating agent for preventing and treating cow mastitis comprises the following components:
wherein the solvent is ethanol.
The preparation method of the film coating agent for preventing and treating the cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan into 20 meshes, putting the medicinal materials into a container according to the formula amount, adding an extraction solvent ethanol, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 3: 1, namely 300ml of ethanol, extracting by a heating reflux extraction method for 2 times, mixing all extracting solutions, filtering, concentrating and preparing a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.3;
2) dissolving the film forming agent in 40ml of solvent, adding borneol, laurocapram, glycerol, carbomer and the concentrated extract of the traditional Chinese medicines into the solvent, and then adding the solvent to 100ml to obtain the film forming agent for preventing and treating the mastitis of the dairy cows.
Example 4
A film coating agent for preventing and treating cow mastitis comprises the following components:
wherein the solvent is 75% (v/v) ethanol water solution.
The preparation method of the film coating agent for preventing and treating the cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan into 20 meshes, putting the medicinal materials into a container according to the formula amount, adding 50% ethanol water solution of an extraction solvent, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 5: 1, namely 550ml of 50% (v/v) ethanol aqueous solution, extracting by a heating reflux extraction method for 2 times, mixing all extracting solutions, filtering, concentrating to prepare a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.3;
2) dissolving the film forming agent in 40ml of solvent, adding borneol, laurocapram, glycerol, hydroxypropyl methylcellulose and the traditional Chinese medicine concentrated extract into the solvent, and then adding the solvent to 100ml to obtain the film forming agent for preventing and treating the mastitis of the dairy cows.
Example 5
A film coating agent for preventing and treating cow mastitis comprises the following components:
wherein the solvent is 70% (v/v) ethanol water solution.
The preparation method of the film coating agent for preventing and treating the cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan into 20 meshes, putting the medicinal materials into a container according to the formula amount, adding 70% ethanol water solution of an extraction solvent, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 4: 1, namely 400ml of 70% (v/v) ethanol aqueous solution, extracting by a heating reflux extraction method for 2 times, mixing all extracting solutions, filtering, concentrating to prepare a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.25;
2) dissolving the film forming agent in 40ml of solvent, adding borneol, laurocapram, glycerol, polyvinyl alcohol and the traditional Chinese medicine concentrated extract into the solvent, and then adding the solvent to 100ml to obtain the film forming agent for preventing and treating the mastitis of the dairy cows.
Example 6
A film coating agent for preventing and treating cow mastitis comprises the following components:
wherein the solvent is 70% (v/v) ethanol water solution.
The preparation method of the film coating agent for preventing and treating the cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan into 20 meshes, putting the medicinal materials into a container according to the formula amount, adding an ethanol water solution with an extraction solvent of 60%, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 4: 1, 480ml of 60% (v/v) ethanol aqueous solution, extracting by a heating reflux extraction method for 2 times, mixing all the extracting solutions, filtering, concentrating to obtain a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.3;
2) dissolving the film forming agent in 40ml of solvent, adding borneol, laurocapram, glycerol, dibutyl phthalate, polyvinyl alcohol and the traditional Chinese medicine concentrated extract into the solvent, and then adding the solvent to 100ml to obtain the film forming agent for preventing and treating the mastitis of the dairy cows.
Example 7
A film coating agent for preventing and treating cow mastitis comprises the following components:
wherein the solvent is 70% (v/v) ethanol water solution.
The preparation method of the film coating agent for preventing and treating the cow mastitis comprises the following steps:
1) respectively crushing rhubarb, abelmoschus manihot, safflower and myrobalan into 30 meshes, putting the medicinal materials into a container according to the formula amount, adding an ethanol water solution with an extraction solvent of 60 percent, wherein the volume ratio of the extraction solvent to the total mass of the medicinal materials is 4: 1, 480ml of 60% (v/v) ethanol aqueous solution, extracting by a heating reflux extraction method for 2 times, mixing all the extracting solutions, filtering, concentrating to obtain a traditional Chinese medicine concentrated extracting solution with the specific gravity of 1.3;
2) dissolving the film forming agent in 40ml of solvent, adding borneol, laurocapram, glycerol, dibutyl phthalate, polyvinyl alcohol and the traditional Chinese medicine concentrated extract into the solvent, and then adding the solvent to 100ml to obtain the film forming agent for preventing and treating the mastitis of the dairy cows.
Comparative example 1
The present comparative example differs from example 6 in that: in this comparative example, sunset abelmoschus flower, safflower and myrobalan were not added.
Comparative example 2
The present comparative example differs from example 6 in that: in this comparative example, rhubarb, safflower and myrobalan were not added.
Comparative example 3
The present comparative example differs from example 6 in that: in this comparative example, no rhubarb, flower of abelmoschus manihot, and myrobalan were added.
Comparative example 4
The present comparative example differs from example 6 in that: in this comparative example, no rhubarb, flower of abelmoschus manihot, safflower were added.
Comparative example 5
The present comparative example differs from example 6 in that: in this comparative example, no sunset abelmoschus flowers were added.
Comparative example 6
The present comparative example differs from example 6 in that: in this comparative example, safflower was not added.
Comparative example 7
The present comparative example differs from example 6 in that: in this comparative example, myrobalan was not added.
Comparative example 8
The present comparative example differs from example 6 in that: in this comparative example, no rhubarb was added.
Performance testing
(1) Test of bacteriostatic Property
The bacteriostatic performance of the film coating agent for preventing and treating milk mastitis obtained in examples 1-7 and comparative examples 1-8 is detected by a cow teat surface bacteriostatic method, wherein the bacteriostatic test method comprises the following steps: selecting 16 dairy cows without mastitis and 15 dairy cows without mastitis as test groups, wherein the physiological conditions are similar, the skin on the surface of the breast is not damaged or suppurated, and the like, the number of the dairy cows is 16, the number of the dairy cows is 15, the test groups are respectively one, the other end of the dairy cows is a control group, and the dairy cows are wiped with purified water 24 hours before the test. Then, the mixture was cultured in a medium (beef extract 3.0g, peptone 5.0g, water 1000ml, pH 7.2-7.4) at 37 ℃ for 24 hours, and the results were shown in Table 1 by separation, counting and calculation of the inhibitory rate. Wherein, the formula for calculating the bacteriostasis rate is as follows:
the bacteriostatic ratio%.
TABLE 1 bacteriostatic property test results of plastics for preventing and treating milk mastitis
As can be seen from Table 1, the bacteriostatic rate of the film coating agent for preventing and treating the cow mastitis obtained in the examples 1 to 7 is obviously higher than that of the comparative examples 1 to 8, the average bacteriostatic rate is above 99.29% and can reach 99.92% at most, and the film coating agent for preventing and treating the cow mastitis disclosed by the invention can be used for inhibiting main pathogenic bacteria on nipples and has a good effect of preventing the cow mastitis.
(2) Clinical treatment testing
The three batches of film coating agents for preventing and treating the mastitis of the dairy cows, which are respectively prepared in the embodiment 2, the embodiment 6, the comparative example 1 and the comparative example 8, are selected as clinical treatment medicines, and the clinical mastitis affected dairy cows are treated, wherein each batch of the three batches of the film coating agents are used for treating 20 affected dairy cows, the treatment observation period is 5 days, and the recurrence rate observation period is 30 days; the treatment method comprises uniformly applying the film coating agent for preventing and treating cow mastitis on the surface of nipple and the affected area of the nipple after each milking.
Judging the treatment effect of the sick cows, wherein the symptoms of red and swollen breasts, heat pain and the like of the sick cows disappear after treatment, and the clinically effective cows have the advantages that the hard breast blocks become soft and have no pain, the body temperature of the breast parts is normal, the milk has no clot, and the color of the milk is normal; the symptoms are not obviously improved or worsened, and the milk abnormality is clinically ineffective; other cases are considered partially valid. Specific test results are shown in table 2.
TABLE 2 clinical treatment test conditions of plastics for preventing and treating cow mastitis
As can be seen from Table 2, the clinical effective rates of the example 2 and the example 6 are 81.70% and 88.30% respectively, the recurrence rates are 3.33%, the clinical effective rates of the comparative example 1 and the comparative example 8 are 60.00% and 65.00% respectively, the recurrence rates are 11.70% and 10.00% respectively, the performance of the example is obviously superior to that of the comparative example by combining the antibacterial test condition of the cow nipple surface, and the recurrence rate is low.
Claims (5)
1. The film coating agent for preventing and treating cow mastitis is characterized by being prepared from the following components:
20-50 g of rhubarb;
10-30 g of sunset abelmoschus flowers;
10-30 g of safflower;
10-30 g of myrobalan;
5-20 g of borneol;
0.1-2 g of laurocapram;
0.1-3 g of film forming agent;
the solvent was added to 100 mL.
2. The coating agent for preventing and treating cow mastitis according to claim 1, which is characterized by further comprising 1-10 g of a skin care agent.
3. The film coating agent for preventing and treating cow mastitis according to claim 2, wherein the skin care agent is at least one of propylene glycol, glycerol, dibutyl phthalate and lanolin.
4. The film coating agent for preventing and treating cow mastitis according to claim 1, wherein the film forming agent is at least one of polyvinyl alcohol, polyvinyl butyral, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, chitosan, palonosom and carbomer.
5. The coating agent for preventing and treating bovine mastitis according to claim 1, wherein the solvent is at least one of ethanol and water.
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|---|---|---|---|---|
| CN109588567A (en) * | 2019-01-30 | 2019-04-09 | 谈宗华 | Cow feed additive and preparation method with prevention and treatment dysentery and raising milk matter effect |
| CN111543554A (en) * | 2020-05-28 | 2020-08-18 | 北京艺亩农林科技有限公司 | Feed formula for lactating cattle |
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| CN106109539A (en) * | 2016-08-09 | 2016-11-16 | 西北农林科技大学 | A kind of Chinese medicinal herb external liniment treating dairy stock mastitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106109539A (en) * | 2016-08-09 | 2016-11-16 | 西北农林科技大学 | A kind of Chinese medicinal herb external liniment treating dairy stock mastitis and preparation method thereof |
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