CN111632089A - Traditional Chinese medicine composition for treating cow mastitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cow mastitis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a traditional Chinese medicine composition for treating cow mastitis, which is prepared from the following raw materials in parts by weight: 60-80 parts of snakegourd fruit, 30-40 parts of selfheal, 30-45 parts of radix bupleuri, 30-40 parts of scutellaria baicalensis, 20-30 parts of fructus forsythiae, 20-30 parts of pericarpium citri reticulatae viride, 20-30 parts of angelica sinensis, 30-40 parts of red paeony root, 20-30 parts of garden balsam seed, 20-30 parts of cowherb seed and 10-20 parts of liquorice. The traditional Chinese medicine composition for treating the cow mastitis has the advantages of small side effect, no residue, no drug resistance, environmental protection and the like, the effective rate of treating the cow mastitis can reach 95.5%, and compared with the traditional antibiotic treatment, the traditional Chinese medicine composition has great advantages and is suitable for wide popularization and application.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for treating cow mastitis and a preparation method thereof.
Background
With the continuous improvement of the living standard of people, the milk becomes a necessary drink in the daily life of people at present, which also promotes the great development of the dairy cow breeding industry in China, however, the prevalence of dairy cow diseases restricts the development of the dairy industry to a certain extent, and the most serious is the mastitis of dairy cows. The symptoms of cow mastitis are parenchymal and interstitial inflammations of breasts, are common diseases in the cow industry, are clinically infected by pathogenic microorganisms such as escherichia coli, staphylococcus aureus, streptococcus agalactiae and the like, and are also important reasons for causing the cow mastitis due to improper application of trauma and milking techniques. The milk yield and the milk quality of the dairy cows after mastitis occurs are obviously reduced, and the treatment cost, the elimination rate and the death rate are increased, so that huge losses are caused to the dairy cow breeding industry.
At present, no effective anti-inflammatory medicine exists, the traditional treatment mostly takes antibiotics as main materials, although a certain treatment effect can be achieved, the treatment period of the antibiotics is long, medicine residues exist in milk, and bacteria are easy to generate drug resistance after the antibiotics are used for a long time, so that the treatment with the antibiotics has great defects.
Therefore, the research and development of a traditional Chinese medicine composition for treating cow mastitis and a preparation method thereof, which have the advantages of small side effect, no residue, no drug resistance and environmental protection, are technical problems to be solved urgently by the technical personnel in the field.
Disclosure of Invention
In view of the above, the invention provides a traditional Chinese medicine composition for treating cow mastitis and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating cow mastitis is prepared from the following raw materials in parts by weight: 60-80 parts of snakegourd fruit, 30-40 parts of selfheal, 30-45 parts of radix bupleuri, 30-40 parts of scutellaria baicalensis, 20-30 parts of fructus forsythiae, 20-30 parts of pericarpium citri reticulatae viride, 20-30 parts of angelica sinensis, 30-40 parts of red paeony root, 20-30 parts of garden balsam seed, 20-30 parts of cowherb seed and 10-20 parts of liquorice.
The invention mechanism of the invention is: according to the traditional Chinese medicine, the mastitis of the dairy cattle belongs to acute mastitis, is inflammation caused by phlegm, dampness, qi and blood stagnation without dispersing, and suppuration and carbuncle formation are caused by meat rot due to excessive heat. The therapeutic principle should be mainly to clear heat and remove toxicity, and the auxiliary should be to soothe liver, promote qi circulation, activate blood, remove stasis, eliminate swelling and eliminate hard mass. In the formula, the snakegourd fruit, the baical skullcap root and the weeping forsythia have the effects of clearing heat and removing toxicity and are used as monarch drugs, the Chinese thorowax root and the immature tangerine peel have the effects of soothing the liver and promoting the circulation of qi, the Chinese angelica and the red paeony root have the effects of activating blood and removing stasis and are used as ministerial drugs, the common selfheal fruit-spike, the garden balsam seed and the cowherb seed have. Wherein:
and (3) snakegourd fruit: sweet, slightly bitter and cold in taste; it enters lung, stomach and large intestine meridians; clearing heat and eliminating phlegm, relieving chest stuffiness and dissipating stagnation, moistening dryness and lubricating intestines, and is used for treating cough due to lung heat, turbid phlegm, yellow and thick phlegm, chest stuffiness and pain, chest stuffiness and fullness, acute mastitis, pulmonary abscess, intestinal abscess swelling and pain, and constipation.
Selfheal: pungent, bitter and cold in nature; it enters liver and gallbladder meridians; clearing liver-fire, improving eyesight, resolving hard mass and relieving swelling; can be used for treating conjunctival congestion, swelling and pain, eye bead nyctalgia, headache, giddiness, scrofula, goiter, mammary abscess, mammary nodules, and breast pain.
Bupleurum root: pungent and bitter in flavor and slightly cold in nature; entering liver, gallbladder and lung meridians; harmonizing exterior and interior, soothing liver-qi stagnation, lifting yang and sinking, allaying fever and checking malaria; can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis.
Scutellaria baicalensis: bitter taste and cold nature; it enters lung, gallbladder, spleen, large intestine and small intestine meridians; clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage; can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Fructus forsythiae: bitter and cool; entering heart, liver and gallbladder meridians; clearing away heat and toxic materials, dispersing pathogenic accumulation, and relieving swelling; it is indicated for warm heat, erysipelas, macula, superficial infection, abscess, swelling, scrofula and stranguria.
Green tangerine peel: bitter and pungent taste, warm in nature; entering liver, gallbladder and stomach meridians; has effects of dispersing stagnated liver qi, relieving qi stagnation, and resolving food stagnation; can be used for treating distending pain in chest and hypochondrium, hernia pain, nodules of breast, mammary abscess, food stagnation, qi stagnation, and abdominal pain.
Chinese angelica: sweet, pungent and warm; it enters liver, heart and spleen meridians; enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness, lubricating intestines, treating various symptoms of blood deficiency, irregular menstruation and amenorrhea; dysmenorrhea, abdominal mass, metrorrhagia, abdominal pain due to cold deficiency, flaccidity, numbness of skin, intestinal dryness, constipation, dysentery, carbuncle, ulcer, traumatic injury.
Red peony root: bitter taste and slightly cold nature; entering liver meridian; clearing heat and cooling blood, and removing blood stasis and relieving pain; can be used for treating heat entering nutrient-blood, toxic heat macula, hematemesis and epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Acute seed: slightly bitter, pungent and warm in nature; has little toxicity; meridian tropism enters lung and liver meridians; break blood and soften hardness, remove food stagnation. Can be used for treating abdominal mass, amenorrhea, and dysphagia.
Seed of cowherb: bitter in nature and mild in taste; entering liver and stomach meridians; promoting blood circulation, dredging channels, promoting lactation, relieving swelling, promoting urination, and treating stranguria; can be used for treating amenorrhea, dysmenorrhea, galactorrhea, acute mastitis, and stranguria with pain.
Licorice root: sweet in taste and neutral in nature; the heart meridian, the lung meridian, the spleen meridian and the stomach meridian; replenishing qi, strengthening the middle warmer, clearing away heat and toxic materials, expelling phlegm, relieving cough, relieving spasm and pain, and regulating drug properties; it can be used for treating spleen qi deficiency, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limbs spasm, pain, toxic heat, pyocutaneous disease, sore throat, and drug and food poisoning; relieve the toxicity and the severity of the drugs.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating cow mastitis, which comprises the following steps:
(1) weighing the raw materials according to the traditional Chinese medicine composition for treating the cow mastitis;
(2) putting the raw materials into a traditional Chinese medicine extraction tank, adding water, heating to boil, and performing reflux extraction to obtain an extract I;
(3) adding water into the traditional Chinese medicine extraction tank again, heating to boil, and performing reflux extraction to obtain an extract II;
(4) and mixing the two extracting solutions, filtering, concentrating the filtrate, and cooling to room temperature to obtain the traditional Chinese medicine composition for treating the mastitis of the dairy cow.
Further, in the step (2), the water adding amount is 8-10 times of the total mass of the raw materials.
Further, in the step (2), water is added, the mixture is heated to boiling, and then the reflux extraction is carried out for 1 to 3 hours.
Further, in the step (3), the water adding amount is 6-8 times of the total mass of the raw materials.
Further, in the step (3), water is added, the decoction is carried out until the decoction is boiled, and the reflux extraction is carried out for 1 to 3 hours.
Further, in the step (4), the concentration temperature of the filtrate is 65-75 ℃, and the vacuum degree is 0.06 MPa.
Further, in the above step (4), the filtrate is concentrated to a relative density of 1.1 to 1.2 with respect to water.
The invention has the beneficial effects that: the traditional Chinese medicine composition for treating the cow mastitis has the advantages of small side effect, no residue, no drug resistance, environmental protection and the like, the effective rate of treating the cow mastitis can reach 95.5%, and compared with the traditional antibiotic treatment, the traditional Chinese medicine composition has great advantages and is suitable for wide popularization and application.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A preparation method of a traditional Chinese medicine composition for treating cow mastitis comprises the following steps:
(1) weighing 60 g of snakegourd fruit, 30 g of selfheal, 30 g of radix bupleuri, 30 g of scutellaria baicalensis, 20 g of fructus forsythiae, 20 g of pericarpium citri reticulatae viride, 20 g of angelica, 30 g of red paeony root, 20 g of garden balsam seed, 20 g of cowherb seed and 10 g of liquorice;
(2) putting the raw materials into a traditional Chinese medicine extraction tank, repeatedly adding water, heating, boiling and performing reflux extraction twice, adding water for the first time, heating, wherein the added water amount is 8 times of the mass of the raw materials, and performing reflux extraction for 1 hour after boiling; adding water for heating for the second time, wherein the water addition amount is 6 times of the raw material weight, boiling, and performing reflux extraction for 1 hour; mixing the two extractive solutions, filtering, concentrating the filtrate to relative density of 1.1, cooling to room temperature, concentrating the filtrate at 65 deg.C and vacuum degree of 0.06 MPa; the traditional Chinese medicine composition for treating the cow mastitis is obtained.
Example 2
A preparation method of a traditional Chinese medicine composition for treating cow mastitis comprises the following steps:
(1) weighing 70 g of snakegourd fruit, 35 g of selfheal, 35 g of radix bupleuri, 35 g of scutellaria baicalensis, 25 g of fructus forsythiae, 25 g of pericarpium citri reticulatae viride, 25 g of angelica, 35 g of red paeony root, 25 g of garden balsam seed, 25 g of cowherb seed and 15 g of liquorice;
(2) putting the raw materials into a traditional Chinese medicine extraction tank, repeatedly adding water, heating, boiling and performing reflux extraction twice, adding water for the first time, heating, wherein the added water amount is 9 times of the mass of the raw materials, and performing reflux extraction for 2 hours after boiling; adding water for heating for the second time, wherein the added water amount is 7 times of the raw material by mass, boiling, and performing reflux extraction for 2 hours; mixing the two extractive solutions, filtering, concentrating the filtrate to relative density of 1.1, cooling to room temperature, concentrating the filtrate at 70 deg.C under vacuum degree of 0.06 MPa; the traditional Chinese medicine composition for treating the cow mastitis is obtained.
Example 3
A preparation method of a traditional Chinese medicine composition for treating cow mastitis comprises the following steps:
(1) weighing 80 g of snakegourd fruit, 40 g of selfheal, 45 g of radix bupleuri, 40 g of scutellaria baicalensis, 30 g of fructus forsythiae, 30 g of pericarpium citri reticulatae viride, 30 g of angelica, 40 g of red paeony root, 30 g of garden balsam seed, 30 g of cowherb seed and 20 g of liquorice;
(2) putting the raw materials into a traditional Chinese medicine extraction tank, repeatedly adding water, heating, boiling and performing reflux extraction twice, adding water for the first time, heating, wherein the added water amount is 10 times of the mass of the raw materials, and performing reflux extraction for 3 hours after boiling; adding water for heating for the second time, wherein the water addition amount is 8 times of the mass of the raw materials, boiling, and performing reflux extraction for 3 hours; mixing the two extractive solutions, filtering, concentrating the filtrate to relative density of 1.2, cooling to room temperature, concentrating the filtrate at 75 deg.C and vacuum degree of 0.06 MPa; the traditional Chinese medicine composition for treating the cow mastitis is obtained.
Effect experiment:
for treating 66 mastitis cows in a certain dairy farm, 1000mL of the traditional Chinese medicine composition prepared in the embodiment 3 is weighed, and the traditional Chinese medicine composition is administrated in a gavage way for 500mL in the morning and 500mL in the afternoon for 3-5 days continuously. The treatment results are as follows: the medicine has the advantages of curing 60 heads, 3 effective heads and 3 ineffective heads, the cure rate is 90.9 percent, the effective rate reaches 95.5 percent, and the satisfactory treatment effect is obtained.
The criteria for cure, efficacy and ineffectiveness are:
and (3) curing: the swelling, pain and fever symptoms of the breast area disappear, the produced milk is recovered to be normal, and the milk is normal.
The method has the following advantages: the pain and fever in the breast area disappear, the swelling still exists, the milk production is increased, but the normal state is not completely recovered, and the milk slightly has flocculent precipitates.
And (4) invalidation: the swelling, pain and fever symptoms of the breast area are not relieved, the milk production is not increased, and the milk has flocculent precipitates.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A traditional Chinese medicine composition for treating cow mastitis is characterized by being prepared from the following raw materials in parts by weight: 60-80 parts of snakegourd fruit, 30-40 parts of selfheal, 30-45 parts of radix bupleuri, 30-40 parts of scutellaria baicalensis, 20-30 parts of fructus forsythiae, 20-30 parts of pericarpium citri reticulatae viride, 20-30 parts of angelica sinensis, 30-40 parts of red paeony root, 20-30 parts of garden balsam seed, 20-30 parts of cowherb seed and 10-20 parts of liquorice.
2. A preparation method of a traditional Chinese medicine composition for treating cow mastitis is characterized by comprising the following steps:
(1) weighing the raw materials according to the traditional Chinese medicine composition for treating cow mastitis in claim 1;
(2) putting the raw materials into a traditional Chinese medicine extraction tank, adding water, heating to boil, and performing reflux extraction to obtain an extract I;
(3) adding water into the traditional Chinese medicine extraction tank again, heating to boil, and performing reflux extraction to obtain an extract II;
(4) and mixing the two extracting solutions, filtering, concentrating the filtrate, and cooling to room temperature to obtain the traditional Chinese medicine composition for treating the mastitis of the dairy cow.
3. The preparation method of the traditional Chinese medicine composition for treating cow mastitis according to claim 2, wherein in the step (2), the water addition amount is 8-10 times of the total mass of the raw materials.
4. The preparation method of the Chinese medicinal composition for treating cow mastitis according to claim 2, wherein in the step (2), water is added, the mixture is heated to boiling, and then the reflux extraction is performed for 1 to 3 hours.
5. The preparation method of the traditional Chinese medicine composition for treating cow mastitis according to claim 2, wherein in the step (3), the water addition amount is 6-8 times of the total mass of the raw materials.
6. The preparation method of the Chinese medicinal composition for treating cow mastitis according to claim 2, wherein in the step (3), water is added, the decoction is carried out until the decoction is boiled, and the reflux extraction is carried out for 1 to 3 hours.
7. The preparation method of the traditional Chinese medicine composition for treating cow mastitis according to claim 2, wherein in the step (4), the concentration temperature of the filtrate is 65-75 ℃, and the vacuum degree is 0.06 MPa.
8. The method for preparing a Chinese medicinal composition for treating bovine mastitis according to claim 2, wherein in the step (4), the filtrate is concentrated to a relative density of 1.1 to 1.2 with respect to water.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190623A (en) * | 2020-11-17 | 2021-01-08 | 李新建 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
| CN114129654A (en) * | 2021-12-22 | 2022-03-04 | 辽宁科技学院 | Pharmaceutical composition and preparation for treating cow mastitis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112190623A (en) * | 2020-11-17 | 2021-01-08 | 李新建 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
| CN114129654A (en) * | 2021-12-22 | 2022-03-04 | 辽宁科技学院 | Pharmaceutical composition and preparation for treating cow mastitis |
| CN114129654B (en) * | 2021-12-22 | 2022-12-06 | 辽宁科技学院 | Pharmaceutical composition and preparation for treating cow mastitis |
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