It is the medicine of active ingredient with Folium et Cacumen Artemisiae Halodendri that one of the object of the invention provides a kind of.
Another object of the present invention provides a kind of pharmaceutical composition that contains Folium et Cacumen Artemisiae Halodendri.
Another object of the present invention provides a kind of external plaster.
Another object of the present invention provides a kind of medicine box.
Realize that technical scheme of the present invention is as follows:
Because Folium et Cacumen Artemisiae Halodendri son never is used as medicine as medicinal in the past, be the present invention for the first time with it as medicinal, therefore,, then belong within protection scope of the present invention as long as with the composition of Folium et Cacumen Artemisiae Halodendri as medicine.
Therefore, the invention provides a kind of medicine, this medicine contains Folium et Cacumen Artemisiae Halodendri or its effective composition that extracts for the treatment of effective dose.
Medicine of the present invention preferably contains Folium et Cacumen Artemisiae Halodendri or its effective composition that extracts of 1-99% weight portion; Folium et Cacumen Artemisiae Halodendri or its effective composition that extracts that more preferably contain the 10-90% weight portion; The Folium et Cacumen Artemisiae Halodendri or its effective composition that extracts that further preferably contain the 20-80% weight portion.
Medicine of the present invention effectively extracts the composition except containing Folium et Cacumen Artemisiae Halodendri or Folium et Cacumen Artemisiae Halodendri for the treatment of effective dose, the pharmaceutical carrier or the excipient that can also contain usual amounts, said excipient can be solvent, solubilizing agent, filler, disintegrating agent, binding agent, wetting agent, lubricant, antiseptic, coloring agent etc.
Medicine of the present invention effectively extracts the composition except containing Folium et Cacumen Artemisiae Halodendri or Folium et Cacumen Artemisiae Halodendri for the treatment of effective dose, also can add other medicament active composition, for example, and antibiotics, analgesic etc.
Effective extraction composition of said Folium et Cacumen Artemisiae Halodendri of the present invention is meant that with Folium et Cacumen Artemisiae Halodendri be raw material, and according to the extract with pharmacologically active that conventional extraction process therefrom extracts with solvent, said here solvent can be an organic solvent, also can be water.
The inventor is the main pharmacodynamics composition with Folium et Cacumen Artemisiae Halodendri also in practice, has invented a kind of pharmaceutical composition, said composition composed as follows: (weight portion)
The sub-0.1-1 of Folium et Cacumen Artemisiae Halodendri;
Mentholum 0.002-0.02;
HERBA VERONICAE DILATATAE 0.02-0.2.
Aforementioned pharmaceutical compositions of the present invention can be prepared into it any topical agent that is suitable for clinical use according to conventional formulation technology, as patch, unguentum, liniment, spray etc.
Aforementioned pharmaceutical compositions is being made in the process of medicine; can be with above-mentioned three kinds of components processed simultaneously, also can be respectively with its processed, and then be prepared into medicament; the medicine that these methods are prepared all is to have utilized the above-mentioned present composition, belongs to protection scope of the present invention.Because water is a kind of solvent commonly used, is preparing with the above-mentioned present composition in the process of medicine, perhaps in the use of the medicine of making, all can add entry, this is equally within protection scope of the present invention.
It is the plaster of component preparation with the aforementioned pharmaceutical compositions that two kinds of distinct methods are provided below.
Method for making one:
Get Folium et Cacumen Artemisiae Halodendri, be ground into fine powder, mix homogeneously, standby.
Get Mentholum, add an amount of dissolve with ethanol after, standby.The ethanol consumption that adds is can make Mentholum degree of being dissolved as.
The water intaking turnip decocts with water 2 times, and 1-3 hour for the first time, preferred 2 hours, 0.5-2 hour for the second time, preferred 1.5 hours, twice decocting liquid merged, and cold preservation 24 hours filters.Amount of water did not have powder degree of being with water.
With filtrate and the abundant mix homogeneously of Mentholum ethanol liquid, standby.
The careful powder of above-mentioned Folium et Cacumen Artemisiae Halodendri is added above-mentioned medicinal liquid 3-6 doubly measure, preferred 5 times of amounts, adding distil water 2-5 doubly measures again, preferred 3 times of amounts, stirring makes into even ointment shape, and sharing ovalisation sheet lyophilization 16-20 hour, takes out again, be pasted on the medical rubber cream, the lid lining is made plaster.Every subsides pastille 0.4 gram.
Method for making two:
(1) gets Folium et Cacumen Artemisiae Halodendri, be ground into 80 order to 200 order powder, gained medicated powder adds entry (1: 1 to 1: 12), stirs into pasty state, puts into garden shape or oval-shaped mould, through-15 ℃ to-80 ℃ freezing 10-24 hour, become solid, shaped, heating up gradually through vacuum is dried to spongiform solid, taking-up, shaping again, be positioned on the gas-pervious medical adhesive-bonded fabric Surgidressing, packing promptly.
(2) get Mentholum 1-10 gram, it is standby to add ethanol 6-60 milliliter (10%-95%V/L concentration).
(3) according to the each component ratio of compositions, take by weighing HERBA VERONICAE DILATATAE according to the Mentholum consumption, decoct with water 2 times, amount of water can not have powder degree of being with water, decocts 1-3 hour for the first time, decocted 0.5-2 hour for the second time, merge decocting liquid twice, leave standstill filtration, in filtrate, add the Mentholum alcoholic solution, make solvent, carry out packing.
Above-mentioned two kinds of plaster that method is made.The lid of tearing in use serves as a contrast, and drips the solvent that makes in the several above-mentioned method for makings two, and postpone is affixed on the affected part slightly.
Although the present invention preferably uses HERBA VERONICAE DILATATAE liquid and the alcoholic acid mixed solvent of Mentholum, also can water, perhaps only with HERBA VERONICAE DILATATAE water extract, or the Mentholum alcoholic solution is as solvent.
Therefore, the invention provides a kind of medicine box, this medicine box comprises sub-patch of Folium et Cacumen Artemisiae Halodendri and solvent.
The sub-patch of said Folium et Cacumen Artemisiae Halodendri be above-mentioned two kinds of methods make any, or the patch made from other conventional methods.
The mixed solvent of prepared HERBA VERONICAE DILATATAE water extract and Mentholum alcoholic solution also can be a water in the preferred above-mentioned method for making two of said solvent, perhaps HERBA VERONICAE DILATATAE aqueous extract, or Mentholum alcoholic solution.
Medicine for external use of the present invention has heat-clearing and toxic substances removing, the effect of blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting, anti-inflammatory analgetic.Be used for various pyretic toxicity carbuncle, acute toothache, parotitis, lymphadenitis, acute appendicitis, various unknown carbuncle, the local congestion and swelling pain that traumatic injury causes; Diseases such as mastitis, cyclomastopathy, scapulohumeral periarthritis, anxious living arthritis redness, lumbago and skelalgia.
The advantage of plaster of the present invention is: handle through refrigerating process, keep whole active ingredients, it is spongy that product becomes, easy to use, directly contacts patient's focus skin, is easy to Transdermal absorption.
Embodiment 1
Folium et Cacumen Artemisiae Halodendri 40 gram Mentholums 0.8 gram HERBA VERONICAE DILATATAE 8 grams
Get Folium et Cacumen Artemisiae Halodendri, be ground into 80 to 200 purpose fine powders, the medical material fine powder adds 1: 10 water, stirs into pasty state, put into the mould of garden shape or ellipse garden shape, through subzero 15 ℃-subzero 80 ℃ freezing, become solid, shaped, heat up gradually through vacuum again and be dried to spongiform solid, take out shaping.Be positioned on the gas-pervious medical adhesive-bonded fabric Surgidressing, packing, promptly.
Embodiment 2
Get Mentholum 0.8 gram, add 75% ethanol 4.8ml, make its dissolving, standby.
Water intaking turnip 8 grams add entry, do not have medical material, decoct 2 times, and 2 hours for the first time, 1.5 hours for the second time, merge the secondary decocting liquid, leave standstill filtration, in filtrate, add the Mentholum alcoholic solution, carry out packing, make solvent.
Below be a series of pharmacodynamicss or the clinical experiment of carrying out with medicine of the present invention, wherein " scorching pain disappears " is the trade name of medicine of the present invention.
Experimental example 1: scorching pain disappears to the influence of mice hot plate method pain threshold
1.1 laboratory animal: 40 of ICR mices, body weight 18g~22g/, male and female half and half.Provide (another arena, Chang'an) by Shaanxi Province's medical experiment animal center
1.2 supply the reagent thing: scorching pain disappears.Provide lot number by the Ruicheng Pharmaceutic Factory, Shanxi Prov: 920801
1.3 experimental period: 4 days-JIUYUE of JIUYUE in 1992 7 days
1.4 experimental technique:
Press the hot plate method principle, glass is placed in constant temperature (55 ± 0.5 ℃) water bath, licking metapedes with mice is index, measures the threshold of pain, mice basis secondary, each interval 5 minutes, and the person gives it up not occur licking the metapedes in 30 seconds.40 mices are divided into 4 groups at random, normal saline matched group, 0.1% dolantin group, the 15% and 25% scorching group that disappears bitterly.Every group of 10 male and female half and half.Route of administration is coated with method outside adopting, and removes the about 2 * 3cm of mouse carotid back wool with 8% sodium sulfide
2, with even outer depilation place that is applied to of medicinal liquid, dosage is 1ml/ then.0.1% society adopts gastric infusion for suddenly group, and dosage by 0.5ml/ only.Respectively organize the mice pain threshold respectively at 30 minutes, 60 minutes, 90 minutes mensuration after the administration.
1.5 experimental result:
Scorching pain disappears to the influence of each group mice hot plate method pain threshold.See Table 1
The scorching pain of table 1 disappears to the influence of each group mice hot plate method pain threshold
Group | Animal (only) | Dosage | Lick the sufficient response time |
Before the administration (s) | After the administration (s) |
????30 | ???60 | ????90 |
Normal saline matched group 0.1% dolantin group 15% scorching pain disappears and organizes the 25% scorching group that disappears bitterly | ?10 ?10 ?10 ?10 | 0.5ml/ only 0.5ml/ 0.5ml/ 0.5ml/ only | ?11.9±1.9 ?13.0±4.5 ?12.1±4.8 ?14.5±5.2 | ?10.4±3.1 ?38.8±10.5 ????*** ?15.2±10.1* ?18.4±11.2 ????** | 12.4±3.9 40.8±12.5 ????*** 17.1±12.0* 22.9±9.1** | 11.8±3.1 39.2±17.3 ????*** 19.4±9.8** 24.4±8.4** |
Each group all compares with the normal saline group: * P<0.05 * * P<0.01 * * * P<0.001
Table 1 experimental result shows: " scorching pain disappears " has the effect of the raising mice hot plate method pain threshold of highly significant.This effect strengthens along with the increase of dose.
Experimental example 2: scorching pain disappears and mice is pressed the influence of tail method pain threshold
2.1 laboratory animal: ICR is 40 of white mices, male and female half and half, and body weight 18~22g/ is only provided by Shaanxi Province's medical experiment animal center.(another arena, Chang'an)
2.2 supply the reagent thing: scorching pain disappears and is provided by Ruicheng, Shanxi pharmaceutical factory.Lot number: 920801
2.3 experimental period: JIUYUE was-7 days on the 6th in 1992
2.4 experimental technique:
2.4.1 the animal grouping, dosage and dosage: 40 mices are 4 groups at random, normal saline matched group, dolantin group (12mg/kg), the 15% and 25% scorching group that disappears bitterly.Every group 10, male and female half and half, each group are 0.1ml/ at the mouse tail coating all.
2.4.2 experimental technique: measure preceding every the mice of administration earlier and react scale value bitterly, easily remove mice too responsive or that pause late,, measure mice after 30 minutes simultaneously and react scale value bitterly then respectively at each mouse tail coating.
Determining instrument adopts Italy to produce U90-Basil mice tenderness instrument, is about to the tenderness instrument and adds the crush-cutting pressurization at mice root 1cm place, starts power supply, along with the weight counterweight is mobile on rule, gain in weight gradually occur shouting to mice till.Scale value on the rule of counterweight traveling is promptly as the pain indicator reaction, and the difference of scale value is threshold of pain raising index before and after the administration.
2.5 experimental result: scorching pain disappears and each group mice is pressed the influence of the tail method threshold of pain, and the result sees table 2 for details.
The scorching pain of table 2 disappears and each treated animal is pressed the influence of the tail method threshold of pain
Group | Animal (only) | Dosage | Threshold of pain improvement value (X ± SE) |
Normal saline matched group dolantin group (120mg/kg) 15% scorching pain disappears and organizes the 25% scorching group that disappears bitterly | ????10 ????10 ????10 ????10 | 0.1ml/ only 0.1ml/ 0.1ml/ 0.1ml/ only | ????0.39±0.41 ????11.2±0.42*** ????1.2±0.90** ????2.2±0.93*** |
Each group all compares with the normal saline matched group: * * P<0.01 * * * P<0.001
Table 2 is the result show: scorching two dosage groups (the 25% and 15%) coating medicine-feeding that disappears bitterly, the raising mice of energy highly significant is pressed tail method pain threshold.
The experimental example 3 scorching 234 routine clinical observation reports that disappear bitterly
We from 1991 in JIUYUE, 92 with scorching pain disappear treatment acute appendicitis, acute mastitis, furuncle, mumps, arthromyodynia 234 examples, and respectively to the acute mastitis ruyi jinhuang powder, ruyi jinhuang san, arthromyodynia is carried out controlled observation with SHANGSHI ZHITONG GAO, has received satisfied effect, now clinical observation result is reported as follows:
Clinical data
One, physical data
The 234 routine objects of observation are outpatient service and inpatient.Wherein
Acute appendicitis 84 examples, male 53 people, women 31 people.16-20 year 5 people among the 84 routine patients, 21-30 year 22 people, 31-40 year 22 people, 41-50 year 18 people, 51-60 year 8 people, 61-70 year 7 people, 72-74 year 2 people.
Furuncle 57 examples, male 34 people, women 23 people, 5 months infant 1 people wherein, 77-13 year 5 people, 21-30 year 40 people, 31-40 year 9 people, 41-50 year 2 goes into.
Acute mastitis observation group and matched group are the women, observation group's 32 examples, 21-30 year 15 people wherein, 31-40 year 14 people, 41-43 year 3 people; Matched group 30 examples, 21-30 year 21 people wherein, 31-40 year 9 people.
Mumps 31 examples, male 12 people, women 19 people, 5-10 year 16 people wherein, 11-20 year 15 people.
Arthromyodynia observation group 30 examples, male 17 people, women 13 people, 21-30 year 11 people wherein, 31-40 year 10 people, 41-50 year 7 people, 51-60 year 2 people.Arthromyodynia matched group 30 examples, male 19 people, women 11 people, 21-30 year 14 people wherein, 31-40 year 13 people, 41-50 year 3 people.
Two, medicament sources
Scorching pain disappears and is provided by Ruicheng, Shanxi pharmaceutical factory.Lot number: 920901
The control drug ruyi jinhuang powder, ruyi jinhuang san is provided by the Drug Manufacturing Room of Affiliated Hospital of Shaanxi College of Traditional Chinese Medicine.Lot number: 920901
SHANGSHI ZHITONG GAO is produced by Xi'an pharmaceutical factory of Johnson ﹠ Johnson, and the accurate word of medicine [(84) No. 0047] is defended in Shan
Three, diagnostic criteria and curative effect determinate standard [formulating] with reference to Ministry of Public Health new drug (Chinese medicine) clinical research guideline and traditional Chinese medical science institution of higher learning state-compiled textbook
(1) acute appendicitis (Ministry of Public Health Chinese medicine clinical research guideline)
[diagnostic criteria]
1, transitivity bottom right stomachache, persistence distending pain, paroxysmal aggravation.
2, there is fixedly tenderness TIANSHU acupoint (ST25) below in right side, and weight person can have rebound tenderness, the blue tail of tension of abdominal muscle cave tenderness.
3, heating, nausea and vomiting, constipation or diarrhoea.
4, the psoas test positive, the colon air test positive.Anus refers to inspection, and there is tenderness in the rectum front wall upper right side.
5, blood examination total white blood cells and neutrophilic granulocyte increase.
[curative effect determinate standard]
Recovery from illness: symptom and sign all disappear.
Take a turn for the better: acute symptom disappears, the incomplete absorber of abscess of appendix or enclosed mass.
Invalid: stomachache increases the weight of transfer operative treatment person.
(2) furuncle (Ministry of Public Health Chinese medicine clinical research guideline)
[diagnostic criteria]
1, stone furuncle (head furuncle is arranged): the red lump of a finger size is arranged on skin, and there is a pus head at the center, comes to a head and promptly heals.
2, hidradenitis suppurativa (blind boil): a red lump is arranged, about about three centimeters of scope, no pus head, the back one soft abscess of suppurating 2-3 day, the back healing rapidly of bursting on skin.
3, heating, xerostomia, constipation, yellow fur, General Symptomies such as rapid pulse can be arranged.
[curative effect determinate standard]
Recovery from illness: furuncle and phyma dissipates or the back healing of bursting, and General Symptoms disappears.
Invalid: this heals that rises furuncle and phyma, can not control recurrence.
(3) acute mastitis (formulating) with reference to " Gynecology of Chinese Medicine " five editions teaching materials
[diagnostic criteria]
1, mostly occur in primipara's the lactication phase, premorbid often has nipple, and mammary areola is chapped or inducement such as galactostasis.
2, newborn portion swelling, pain or fear of cold heating.
3, local red, swollen, hot, bitterly, touch the wellability lump, tenderness is arranged, after abscess forms fluctuation can be arranged.The homonymy oxter has lymphadenectasis; Touch a tender spot.
4, blood leukocytes and neutrophilic granulocyte counting increases, and the karyolobism counting moves to left.
5, ultrasonic examination has the flat section of liquid, and pus is extracted in puncture out.
[curative effect determinate standard]
Recovery from illness: swelling and General Symptoms disappear.
Produce effects: swelling alleviates, and General Symptoms alleviates.
Effectively: pain relief, but swelling and General Symptoms improvement are not obvious.
Invalid: symptom and sign do not have improvement.
(4) mumps (formulating) with reference to " Pediatrics of Chinese Medicine " five editions teaching materials
[diagnostic criteria]
1, often there is the mumps contact history in premorbid 2-3 week.
2, their early stage has heating, headache, poor appetite or vomiting is arranged, cheek enlargement in 1-2 days.
3, the swelling position is the center with the ear-lobe, overflow to swell, and blur margin, flexible sense, harden in the part, and pain can swell and ache by concurrent scrotum.
4, lab testing, total white blood cells is normal or on the low side, divides quasi-lymphocyte to increase relatively, and when complication was arranged, total white blood cells and neutrality increased.
[curative effect determinate standard]
Recovery from illness: body temperature is reduced to normally, and cheek swells and ache and General Symptoms disappears.
Produce effects: body temperature descends, and the cheek congestion and swelling pain obviously alleviates.
Effectively: pain relief, lump does not disappear.
Invalid: General Symptoms and local no any improvement.
(5) arthromyodynia (formulating) with reference to " Surgery of Chinese Medicine " five editions teaching materials
[diagnostic criteria]
1, anemofrigid-damp arthralgia
(1) migratory arthralgia: limbs joint is ached, migratory pain, and the joint joint stuffiness, fever with chills very often from the beginning of anemophobia being arranged, diseases such as heating, thin and greasy fur floating pulse more.
(2) arthralgia aggravated by cold: limbs joint pain is obvious, and localized pain is met cold type of pain and weighed, must be by then relaxing, and day light night is heavy, the joint unable to flex and stretch the extremities, local color of the leather is not red, the creeping chill that touches, tongue fur the lung-pulse stringy and tense pulse.
(3) damp arthralgia: the muscle apathy, limbs are weighing pain, and sore spot is fixing not to be moved, or affected part swelling, and it is not nimble to take action, and De Rede is by then pain can be slow slightly, and the pale tongue tongue is greasy in vain, relaxed and soft pulse.
2, pad numbness
Onset is than the trial of strength of acute disease gesture, and joint congestion and swelling pain must coldly then relax, spasm of muscles and vessels, and how with the fever of the body micro evil wind, very then high fever is thirsty, and restlessness with opprssive feeling and worry is liked cold aversion to heat, red tongue, dry, rough and yellow fur, slippery and rapid pulse.
3, rheumatism involving the bone
Big arthralgia, stiff, limitation of activity rises or have a rest and increase the weight of morning.Alleviate arthroncus or the sound is arranged after the activity.The X line shows that the joint space narrows down, and subchondral bone has sclerosis and blister cavities to form, or bony spur is arranged.
[curative effect determinate standard]
Recovery from illness: arthralgia swelling disappears, and General Symptoms disappears.
Produce effects: arthralgia obviously alleviates, but activity still has pain.
Effectively: pain relief, idol has pain during rest.
Invalid: symptom does not have improvement.
Observational technique
Meet object of observation person, add dedicated solvent furnishing pasty states with scorching 5 grams that disappear bitterly and spread on the affected part, and cover thin plastic paper, changed dressings once in per 8 hours.No matter which kind of sick medication is 24 hours, and symptom and sign does not have to improve and is considered as invalid case.
The acute mastitis matched group adds green tea with ruyi jinhuang powder, ruyi jinhuang san or vinegar is transferred deposited affected part, outer plastic covering paper.The arthromyodynia matched group sticks the affected part with SHANGSHI ZHITONG GAO, changes dressings once in 8 hours.
Look disease in the observation and plant the selection hemogram, erythrocyte sedimentation rate and anti-laboratory examinations such as " 0 " are write down before, during and after medication three times altogether.Viewing duration forbidding and this medicine have the other medicines of similar functions.
Therapeutic outcome
Acute mastitis observation group 32 examples, matched group 30 examples (stochastic sampling) therapeutic outcome sees Table 1
Two groups of Comparison of therapeutic results of table 1 acute mastitis
Group | The example number | Recovery from illness (accounting for total routine number) | Produce effects (accounting for total routine number) | Effectively (account for total routine number) | Invalid (accounting for total routine number) | Total effective rate | The result |
The scorching observation group that disappears bitterly | 32 | ?26(81%) | 2(6.3%) | 1(3.1%) | 3(9.4%) | 90.6% | ?P<0.05 |
Golden yellow observation group complies with one's wishes | 30 | ?11(36.6%) | 5(16.7%) | 9(30%) | 5(16.7%) | 83.3% | |
Observed result shows that the scorching curative effect that disappears observation group bitterly obviously is better than ruyi jinhuang powder, ruyi jinhuang san matched group curative effect.There were significant differences to learn processing by statistics, P value<0.05.Each 30 examples (stochastic sampling) observed result of arthromyodynia observation group and matched group sees Table 2
Two groups of Comparison of therapeutic results of table 2 arthromyodynia
Group | The example number | Recovery from illness (accounting for total example applies) | Produce effects (accounting for total routine number) | Effectively (account for total routine number) | Invalid (accounting for total routine number) | Total effective rate | P<0.01 as a result |
The scorching observation group that disappears bitterly | 30 | ?19(63.35%) | 7(23.6%) | 2(6.6%) | 2(6.6%) | 93.3% |
SHANGSHI ZHITONG GAO observation group | 30 | ?8(26.6%) | 3(10%) | 13(43.3%) | 6(20%) | 80% |
Observed result shows that the scorching observation group's curative effect that disappears bitterly of arthromyodynia obviously is better than SHANGSHI ZHITONG GAO matched group curative effect, and learning by statistics to handle has utmost point significant difference, P<0.01.
Acute appendicitis, mumps, furuncle clinical observation result see Table 3-table 5
Table 3 morbid state clinical observation result
The example number | Recovery from illness (accounting for total routine number) | Take a turn for the better (accounting for total routine number) | Invalid (accounting for total routine number) | Average analgesic time | Total effective rate |
84 | ?63(75%) | 12(14%) | 9(10.7%) | 6 hours | 89.3% |
Table 4 mumps clinical observation result
The example number | Recovery from illness (accounting for total routine number) | Produce effects (accounting for total routine number) | Effectively (account for total routine number) | Invalid (accounting for total routine number) | Average analgesic time | The average detumescence time | Total effective rate |
31 | ?24(77%) | 2(6.5%) | 2(6.5%) | 3(9.7%) | 4.6 hour | 74 hours | 90.3% |
Table 5 furuncle clinical observation result
The example number | Recovery from illness (accounting for total routine number) | Invalid (accounting for total routine number) | Average analgesic time | The average detumescence time | Total effective rate |
57 | ?54(94.7%) | 3(5.3%) | 3 hours | 53 hours | 94.7% |
It is remarkable to the clinical efficacy of acute appendicitis, mumps, furuncle that above observed result shows that scorching pain disappears, and alleviating pain and detumescence effect is preferably arranged, and uses through 234 routine patients and do not find obvious toxic-side effects.
Discuss
The external used medicine that scorching pain disappears and makes for pure Chinese medicine, confirm that through 234 routine clinical observations these product are to sick evident in efficacy such as furuncle, mumps, acute appendicitis, acute mastitis and arthromyodynia confirm that through the matched group paired observation these product obviously are better than SHANGSHI ZHITONG GAO to the curative effect of arthromyodynia, and the curative effect of acute mastitis obviously is better than ruyi jinhuang powder, ruyi jinhuang san.Scorching pain disappears to the average total effective rate 91.64% of above all sick treatments, and the alleviating pain and detumescence time is short, easy to use, has avoided the hardship of operation mostly, and the patient takes like a shot more.