CN107158126B - Anti-inflammatory and analgesic composition - Google Patents
Anti-inflammatory and analgesic composition Download PDFInfo
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- CN107158126B CN107158126B CN201710446175.9A CN201710446175A CN107158126B CN 107158126 B CN107158126 B CN 107158126B CN 201710446175 A CN201710446175 A CN 201710446175A CN 107158126 B CN107158126 B CN 107158126B
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Abstract
The invention relates to a traditional Chinese medicine composition for diminishing inflammation and relieving pain, which is prepared from the following raw material medicines: chinese angelica, eucommia bark, szechuan lovage rhizome, fortune's drynaria rhizome, cibotium barometz, Chinese taxillus twig, teasel root, medicinal cyathula root, costus root, cassia twig, dahurian angelica root, baical skullcap root, amur corktree bark, corydalis tuber and clematis root. The invention also provides the application of the traditional Chinese medicine composition. Its advantages are: the traditional Chinese medicine composition of the invention supplements each other, accords with the theory of traditional Chinese medicine, and can effectively diminish inflammation and relieve pain. The functional indications are as follows: relaxing muscles and tendons, promoting blood circulation, relieving inflammation, and alleviating pain. Can be used for treating acute and chronic injury, joint pain, and lumbar muscle strain. The traditional Chinese medicine composition disclosed by the invention is proved by tests to be capable of obviously improving the pain threshold of mice and has obvious curative effects on acute soft tissue injury, chronic soft tissue injury, knee joint pain and lumbar muscle strain.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an anti-inflammatory and analgesic composition.
Background
With the changes of the working environment and the life rhythm of the modern society and the aggravation of the aging of the population, the health, the daily life and the work of people are influenced by traumatic injuries and soreness and pain of the waist and the knees caused by various factors. Conventional western medicine treatment is only simple trauma treatment and symptomatic treatment, and besides local anesthetics, many local or systemic antipyretics and analgesics relieve inflammation and pain in a short time, but often cause local skin irritation and gastrointestinal side effects. Although the traditional Chinese medicine has quick effect, the traditional Chinese medicine treats the symptoms and the root causes, and can only naturally repair the soft tissue injury by the organism, so that the complete healing still needs a long time.
The joint pain of human body mainly includes traumatic injury, injury of tendons and bones, bone injury, arthralgia, osteoarthritis, rheumatic arthritis, rheumatoid arthritis, hyperosteogeny, lumbar muscle strain, sciatica, prolapse of lumbar intervertebral disc and other limb joint and local pain.
Lumbar muscle strain is a common clinical disease, frequently encountered diseases and more pathogenic factors, the main symptoms are waist soreness, the daily fatigue is aggravated, the muscle fiber degeneration can be relieved after rest, the muscle fiber is torn in a small amount after the daily fatigue, scars or fiber ropes or adhesion are formed, and long-term chronic low back pain is left.
Chinese patent document CN103330735A discloses an anti-inflammatory analgesic: 12-30% of dry alhagi sparsifolia alkaline essential oil, 1-2% of camphor, 0.3-0.8% of menthol, 0.7-1% of borneol, 56-63% of 95% alcohol and 8.2-23% of distilled water. Chinese patent document CN101066402 discloses an anti-inflammatory analgesic traditional Chinese medicine: 200-220 parts of desmodium styracifolium, 100-115 parts of plantain, 100-115 parts of pyrrosia lingua and 45-60 parts of corn stigma. Chinese patent document CN102716277A discloses an anti-inflammatory analgesic: 40-60 parts of sophora moorcroftiana seeds, 5-15 parts of saffron crocus, 25-35 parts of snow lotus herb, 3-12 parts of aconitum pendulum, 40-50 parts of tinospora sinensis, 35-55 parts of himalayan jasmine and 2-10 parts of snow lard. However, there is no report on the anti-inflammatory analgesic composition of the present invention.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide an anti-inflammatory and analgesic composition.
It is still another object of the present invention to provide an anti-inflammatory analgesic composition.
In order to achieve the purpose, the invention adopts the technical scheme that: the traditional Chinese medicine composition for diminishing inflammation and relieving pain is prepared from the following raw material medicines in parts by weight: 15-25 parts of angelica sinensis, 20-30 parts of eucommia ulmoides, 20-30 parts of ligusticum wallichii, 15-25 parts of rhizoma drynariae, 20-30 parts of rhizoma cibotii, 25-35 parts of parasitic loranthus, 8-12 parts of teasel root, 20-30 parts of medicinal cyathula root, 8-12 parts of costus root, 18-28 parts of cassia twig, 12-22 parts of radix angelicae, 25-35 parts of scutellaria baicalensis, 20-30 parts of golden cypress, 8-12 parts of rhizoma corydalis and 8-12 parts of radix clematidis.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 18-22 parts of angelica sinensis, 23-27 parts of eucommia ulmoides, 23-27 parts of ligusticum wallichii, 18-22 parts of rhizoma drynariae, 23-27 parts of rhizoma cibotii, 28-32 parts of parasitic loranthus, 9-11 parts of teasel root, 23-27 parts of radix cyathulae, 9-11 parts of costus root, 21-25 parts of cassia twig, 15-19 parts of radix angelicae, 28-32 parts of scutellaria baicalensis, 23-27 parts of cortex phellodendri, 9-11 parts of rhizoma corydalis and 9-11 parts of radix clematidis.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20 parts of angelica sinensis, 25 parts of eucommia ulmoides, 25 parts of ligusticum wallichii, 20 parts of rhizoma drynariae, 25 parts of rhizoma cibotii, 30 parts of loranthus parasiticus, 10 parts of teasel root, 25 parts of medicinal cyathula root, 10 parts of costus root, 23 parts of cassia twig, 17 parts of radix angelicae, 30 parts of scutellaria baicalensis, 25 parts of cortex phellodendri, 10 parts of rhizoma corydalis and 10 parts of radix clematidis.
In order to achieve the second object, the invention adopts the technical scheme that: the application of the traditional Chinese medicine composition in preparing medicines for diminishing inflammation and relieving pain.
Further, the medicament dosage form is a plaster or a patch.
Further, the application of the traditional Chinese medicine composition in preparing a medicine for treating acute and chronic injuries.
Further, the traditional Chinese medicine composition is applied to preparation of a medicine for treating joint soreness.
Further, the traditional Chinese medicine composition is applied to preparation of medicines for treating lumbar muscle strain.
The invention has the advantages that:
1. the traditional Chinese medicine composition provided by the invention supplements each other, accords with the theory of traditional Chinese medicine, has comprehensive effects of each component, and can effectively diminish inflammation and relieve pain.
2. The traditional Chinese medicine composition of the invention has the main function indications: relaxing muscles and tendons, promoting blood circulation, relieving inflammation, and alleviating pain. Can be used for treating acute and chronic injury, joint pain, and lumbar muscle strain.
3. The traditional Chinese medicine composition disclosed by the invention is proved by tests to be capable of obviously improving the pain threshold of mice and has obvious curative effects on acute soft tissue injury, chronic soft tissue injury, knee joint pain and lumbar muscle strain.
Detailed Description
The following examples are provided to illustrate specific embodiments of the present invention.
The invention provides a traditional Chinese medicine composition for diminishing inflammation and relieving pain, which comprises the following components in part by weight: chinese angelica, eucommia bark, szechuan lovage rhizome, fortune's drynaria rhizome, cibotium barometz, Chinese taxillus twig, teasel root, medicinal cyathula root, costus root, cassia twig, dahurian angelica root, baical skullcap root, amur corktree bark, corydalis tuber and clematis root.
EXAMPLE 1 Chinese medicinal composition
15 parts of angelica, 25 parts of eucommia bark, 30 parts of ligusticum wallichii, 15 parts of rhizoma drynariae, 25 parts of rhizoma cibotii, 29 parts of parasitic loranthus, 10 parts of teasel root, 24 parts of medicinal cyathula root, 12 parts of costus root, 23 parts of cassia twig, 12 parts of angelica dahurica, 30 parts of scutellaria baicalensis, 25 parts of phellodendron amurense, 10 parts of corydalis tuber and 10 parts of clematis root.
EXAMPLE 2 Chinese medicinal composition
16 parts of angelica, 24 parts of eucommia bark, 29 parts of ligusticum wallichii, 25 parts of drynaria rhizome, 24 parts of cibotium barometz, 30 parts of parasitic loranthus, 9 parts of teasel root, 26 parts of medicinal cyathula root, 11 parts of costus root, 24 parts of cassia twig, 13 parts of angelica dahurica, 34 parts of scutellaria baicalensis, 21 parts of phellodendron, 12 parts of corydalis tuber and 8 parts of clematis root.
Example 3 Chinese medicinal composition
17 parts of angelica sinensis, 26 parts of eucommia ulmoides, 28 parts of ligusticum wallichii, 16 parts of rhizoma drynariae, 26 parts of rhizoma cibotii, 31 parts of parasitic loranthus, 9 parts of teasel root, 23 parts of medicinal cyathula root, 12 parts of costus root, 22 parts of cassia twig, 14 parts of radix angelicae, 26 parts of scutellaria baicalensis, 29 parts of phellodendron amurense, 9 parts of rhizoma corydalis and 11 parts of radix clematidis.
EXAMPLE 4 Chinese medicinal composition
18 parts of angelica, 23 parts of eucommia, 27 parts of ligusticum wallichii, 24 parts of rhizoma drynariae, 23 parts of rhizoma cibotii, 28 parts of parasitic loranthus, 11 parts of teasel root, 27 parts of medicinal cyathula root, 11 parts of costus root, 25 parts of cassia twig, 15 parts of angelica dahurica, 35 parts of scutellaria baicalensis, 20 parts of phellodendron amurense, 12 parts of corydalis tuber and 8 parts of clematis chinensis.
EXAMPLE 5 Chinese medicinal composition
19 parts of angelica sinensis, 27 parts of eucommia ulmoides, 26 parts of ligusticum wallichii, 17 parts of rhizoma drynariae, 27 parts of rhizoma cibotii, 32 parts of parasitic loranthus, 11 parts of teasel root, 22 parts of medicinal cyathula root, 10 parts of costus root, 21 parts of cassia twig, 16 parts of radix angelicae, 25 parts of scutellaria baicalensis, 30 parts of phellodendron amurense, 8 parts of corydalis tuber and 12 parts of radix clematidis.
EXAMPLE 6 Chinese medicinal composition
20 parts of angelica sinensis, 22 parts of eucommia ulmoides, 25 parts of ligusticum wallichii, 23 parts of rhizoma drynariae, 22 parts of rhizoma cibotii, 27 parts of parasitic loranthus, 12 parts of teasel root, 28 parts of medicinal cyathula root, 10 parts of costus root, 26 parts of cassia twig, 17 parts of radix angelicae, 33 parts of scutellaria baicalensis, 28 parts of golden cypress, 8 parts of corydalis tuber and 8 parts of radix clematidis.
Example 7 Chinese medicinal composition
21 parts of angelica, 28 parts of eucommia bark, 24 parts of ligusticum wallichii, 18 parts of rhizoma drynariae, 28 parts of rhizoma cibotii, 33 parts of parasitic loranthus, 12 parts of teasel root, 21 parts of medicinal cyathula root, 9 parts of costus root, 20 parts of cassia twig, 18 parts of angelica dahurica, 32 parts of scutellaria baicalensis, 27 parts of phellodendron bark, 11 parts of corydalis tuber and 11 parts of clematis root.
Example 8 Chinese medicinal composition
22 parts of angelica sinensis, 21 parts of eucommia ulmoides, 23 parts of ligusticum wallichii, 22 parts of rhizoma drynariae, 21 parts of rhizoma cibotii, 26 parts of parasitic loranthus, 8 parts of teasel root, 29 parts of medicinal cyathula root, 9 parts of costus root, 27 parts of cassia twig, 19 parts of radix angelicae, 28 parts of scutellaria baicalensis, 23 parts of phellodendron amurense, 9 parts of rhizoma corydalis and 9 parts of radix clematidis.
Example 9 Chinese medicinal composition
23 parts of angelica sinensis, 29 parts of eucommia ulmoides, 22 parts of ligusticum wallichii, 19 parts of rhizoma drynariae, 29 parts of rhizoma cibotii, 34 parts of parasitic loranthus, 8 parts of teasel root, 25 parts of medicinal cyathula root, 8 parts of costus root, 19 parts of cassia twig, 20 parts of radix angelicae, 31 parts of scutellaria baicalensis, 26 parts of phellodendron amurense, 9 parts of corydalis tuber and 9 parts of radix clematidis.
Example 10 Chinese medicinal composition
24 parts of angelica sinensis, 20 parts of eucommia ulmoides, 21 parts of ligusticum wallichii, 21 parts of rhizoma drynariae, 20 parts of rhizoma cibotii, 25 parts of loranthus parasiticus, 9 parts of teasel root, 20 parts of medicinal cyathula root, 8 parts of costus root, 28 parts of cassia twig, 21 parts of radix angelicae, 29 parts of scutellaria baicalensis, 24 parts of cortex phellodendri, 11 parts of rhizoma corydalis and 11 parts of radix clematidis.
EXAMPLE 11 Chinese medicinal composition
25 parts of angelica, 30 parts of eucommia bark, 20 parts of ligusticum wallichii, 20 parts of rhizoma drynariae, 30 parts of rhizoma cibotii, 35 parts of loranthus parasiticus, 11 parts of teasel root, 30 parts of medicinal cyathula root, 10 parts of costus root, 18 parts of cassia twig, 22 parts of angelica dahurica, 30 parts of scutellaria baicalensis, 25 parts of phellodendron, 10 parts of corydalis tuber and 10 parts of clematis root.
EXAMPLE 12 Chinese medicinal composition
20 parts of angelica sinensis, 25 parts of eucommia ulmoides, 25 parts of ligusticum wallichii, 20 parts of rhizoma drynariae, 25 parts of rhizoma cibotii, 30 parts of loranthus parasiticus, 10 parts of teasel root, 25 parts of medicinal cyathula root, 10 parts of costus root, 23 parts of cassia twig, 17 parts of radix angelicae, 30 parts of scutellaria baicalensis, 25 parts of cortex phellodendri, 10 parts of rhizoma corydalis and 10 parts of radix clematidis.
EXAMPLE 13 plaster
The traditional Chinese medicine composition of any one of embodiments 1-12 is dried at low temperature, pulverized, weighed according to the above proportion, mixed with 4g of borneol, pulverized, sieved by a 200-mesh sieve, heated over water to be dissolved by 110g of vaseline, added into the powder and stirred uniformly to obtain the plaster.
EXAMPLE 14 Patch preparation
The traditional Chinese medicine composition of any one of embodiments 1-12 is dried at low temperature, crushed, weighed according to the above ratio, added with 5 times of water, decocted for 2 times, 1 hour each time, combined with the two decoctions, concentrated into extract, and placed on a breathable medical non-woven medical adhesive plaster to prepare the patch.
Comparative example 1
10 parts of angelica sinensis, 10 parts of eucommia ulmoides, 10 parts of ligusticum wallichii, 10 parts of rhizoma drynariae, 10 parts of rhizoma cibotii, 10 parts of loranthus parasiticus, 10 parts of teasel root, 10 parts of medicinal cyathula root, 10 parts of costus root, 10 parts of cassia twig, 10 parts of radix angelicae, 10 parts of scutellaria baicalensis, 10 parts of cortex phellodendri, 10 parts of rhizoma corydalis and 10 parts of radix clematidis.
Comparative example 2
20 parts of angelica, 25 parts of eucommia bark, 25 parts of ligusticum wallichii, 20 parts of rhizoma drynariae, 30 parts of parasitic loranthus, 10 parts of teasel root, 25 parts of medicinal cyathula root, 10 parts of costus root, 17 parts of angelica dahurica, 30 parts of scutellaria baicalensis, 25 parts of golden cypress, 10 parts of corydalis tuber and 10 parts of liquorice.
Comparative example 3
Antiphlogistic and analgesic ointment, hang zhou rende medicine limited.
Example 15 Hot plate pain threshold in mice
Experimental animals: 60 ICR mice, 18-22 g/mouse, and half of each mouse.
Animal grouping: the 60 mice were randomly divided into 6 groups: a saline group, a 0.1% dolantin group, a comparative example 1 group (plaster prepared by the method of example 13), a comparative example 2 group (plaster prepared by the method of example 13), a comparative example 3 group, and an example 12 group (plaster prepared by the method of example 13). Each group comprises 10 male and female halves.
The experimental method comprises placing glass in a water bath box with a constant temperature of 55 + -0.5 deg.C, measuring the basal pain threshold of mouse twice with the interval of 5 min for each time by using the licked foot of mouse as index, discarding the licked foot within 30 s, and removing the hair at the back of mouse neck by 8% sodium sulfide via external coating method to obtain the final product of 2 × 3cm2Then uniformly coating the liquid medicine on the depilatory part, wherein the dosage is 1ml per unit. The 0.1% dolantin group is administered by intragastric administration at a dose of 1 ml/tube. The pain threshold was determined for each group of mice at 30 min, 60 min, 90 min post-dose, respectively.
The experimental results are as follows: the effect of hot plate pain threshold in each group of mice is shown in table 1.
TABLE 1 Effect of Hot plate pain threshold in groups of mice
Table 1 the experimental results show that: the traditional Chinese medicine composition in example 12 has a very significant effect of improving the hot plate pain threshold of mice.
Example 16 pain threshold by tail pressure method in mice
Experimental animals: the ICR line white mice are 60 mice, each half of the mice is male and female, and the weight of each mouse is 18-22 g.
Animal grouping: the 60 mice were randomly divided into 6 groups: a saline group, a dolantin group (12mg/kg), a comparative example 1 group (a plaster prepared by the method of example 13), a comparative example 2 group (a plaster prepared by the method of example 13), a comparative example 3 group, and an example 12 group (a plaster prepared by the method of example 13). Each group comprises 10 male and female halves.
The experimental method comprises the following steps: the pain response scale value of each mouse is firstly measured before administration, over-sensitive or slow mice are removed, then the drug is respectively applied to the tail of each mouse, and the pain response scale value of the mice is simultaneously measured after 30 minutes. The tenderness tester is pressed at the position of 1cm of the root of the mouse, the power supply is started, and the weight is gradually increased until the mouse is fizzy as the weight and the weight move on the graduated scale. The scale value on the graduated scale with the running weight is used as the pain response index, and the difference between the scale values before and after administration is the pain threshold raising index.
The experimental results are as follows: the effect of the threshold of pain in the tail-biting procedure in each group of mice is shown in Table 2.
TABLE 2 Effect of the threshold of pain in the tail-biting procedure in groups of mice
The experimental results of table 2 show that: the external application of the traditional Chinese medicine composition in example 12 can remarkably improve the pain threshold of the tail pressing method of the mouse.
Example 17 clinical trials of acute and chronic injury
1 general data
The 100 acute and chronic injury patients come from outpatients and inpatients of our hospital, 78 men and 22 women, the ages of 14-56 years, and the average age of 28 years. 64 cases of acute soft tissue injuries and 36 cases of chronic soft tissue injuries.
2 method of treatment
Treatment groups: the Chinese medicinal composition of example 12 the plaster prepared by the method of example 13 is applied to the affected part (usual amount), covered with a dressing, fixed with an adhesive tape, and changed one day.
Control group: antiphlogistic and analgesic ointment, hang zhou rende medicine limited. Change every day.
A treatment course is 15 days.
3 standard of therapeutic effect
And (3) healing: after 1-2 treatment courses, swelling disappears, conscious pain disappears, no pressure pain exists on the part, and functional activities are normal;
improvement: the swelling and pain and the local tenderness are relieved after 3-4 courses of treatment, and the functional activity is improved;
and (4) invalidation: after 4 courses of treatment, the symptoms and signs do not change obviously.
4 results
The treatment results of 64 cases of acute soft tissue injury patients and 36 cases of chronic soft tissue injury patients are respectively shown in tables 3 and 4, and the treatment effect of the treatment group is remarkably superior to that of the control group (P is less than 0.05).
TABLE 364 results of acute soft tissue injury treatment
TABLE 436 results of chronic soft tissue injury treatment
EXAMPLE 18 clinical trial of Knee Joint pain
1 general data
The 71 patients with knee joint pain are all outpatients and inpatients in our hospital, wherein 39 men and 32 women have the average age of 44 years and the course of the disease lasts for 1-6 days. All patients suffered from one-sided knee joint pain (such as pain on the heavier side on both sides), and had limited mobility. 71 patients are randomly divided into a treatment group and a control group according to the treatment sequence, wherein the treatment group comprises 36 patients, and the control group comprises 35 patients. The age, sex and severity of the disease of the two groups of patients have no statistical difference.
2 method of treatment
Treatment groups: the Chinese medicinal composition of example 12 the plaster prepared by the method of example 13 is applied to the affected part (usual amount), covered with a dressing, fixed with an adhesive tape, and changed one day. A treatment course is 5 days.
Control group: the capsule is administered 3 times a day, 1 granule each time, and 15 times in total.
3 standard of therapeutic effect
And (3) curing: clinical symptoms disappear, the affected joints have no local pressure pain, the bone joints move freely, and the disease does not relapse after half a year of follow-up visit;
the method has the following advantages: the clinical symptoms are obviously improved, the pain is obviously relieved, the local tenderness is not obvious, the bone joint movement is improved, and the disease is easy to relapse when meeting climate change or fatigue;
and (4) invalidation: there was no improvement in clinical signs.
4 results
The treatment results of 71 knee joint pain patients are shown in table 5, and the curative effect of the treatment group is obviously better than that of the control group (P is less than 0.05).
TABLE 571 treatment results for patients with knee joint pain
EXAMPLE 19 clinical trial for lumbar muscle degeneration
1 general data
116 patients with lumbar muscle strain are outpatients and inpatients of the hospital, the affected parts have no skin damage, and bony lesions are eliminated by X-rays. 60 men and 56 women have the age of 18-65 years and the course of disease is 5 months-16 years. The treatment group and the control group are randomly divided according to the treatment sequence, and 58 cases of the treatment group and the control group are respectively used. The age, sex, disease degree and clinical manifestation of the two groups of patients have no statistical difference and are comparable.
2 method of treatment
Treatment groups: the Chinese medicinal composition of example 12 the plaster prepared by the method of example 13 is applied to the affected part (usual amount), covered with a dressing, fixed with an adhesive tape, and changed one day.
Control group: the diclofenac diethylamine emulsion is externally used in a proper amount according to the area of the pain part of a patient, and is gently kneaded at the same time, so that the medicine slowly permeates the skin for 3-4 times in 1 day.
The treatment group and the control group take 20 days as one treatment course, and the treatment and observation are carried out on the treatment group and the control group in two consecutive treatment courses.
3 standard of therapeutic effect
The traditional Chinese medicine composition is prepared by referring to 'traditional Chinese medicine disease diagnosis curative effect standard' issued by the State administration of traditional Chinese medicine and combining with the condition improvement of patients before and after treatment.
And (3) healing: the pain disappears, the activity of the waist muscle is recovered to be normal, and the disease does not relapse for half a year;
the effect is shown: the pain is obviously relieved, the discomfort is caused by the occasional feeling, the activity of the waist muscle is obviously improved, and the repeated times are obviously reduced;
the method has the following advantages: the pain is relieved, the muscle activity is slightly improved, and the repeated times are slightly reduced;
and (4) invalidation: no obvious change before and after treatment.
4 results
The treatment results of 116 patients with lumbar muscle strain are shown in Table 6, and the curative effect of the treatment group is obviously better than that of the control group (P is less than 0.05).
Table 6116 patients with lumbar muscle strain
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (6)
1. The traditional Chinese medicine composition with the effects of diminishing inflammation and relieving pain is characterized by being prepared from the following raw material medicines in parts by weight: 20 parts of angelica sinensis, 25 parts of eucommia ulmoides, 25 parts of ligusticum wallichii, 20 parts of rhizoma drynariae, 25 parts of rhizoma cibotii, 30 parts of loranthus parasiticus, 10 parts of teasel root, 25 parts of medicinal cyathula root, 10 parts of costus root, 23 parts of cassia twig, 17 parts of radix angelicae, 30 parts of scutellaria baicalensis, 25 parts of cortex phellodendri, 10 parts of rhizoma corydalis and 10 parts of radix clematidis.
2. The use of the composition of claim 1 in the preparation of a medicament having anti-inflammatory and analgesic effects.
3. Use according to claim 2, wherein the pharmaceutical dosage form is a plaster or patch.
4. The use of the composition of claim 1 in the preparation of a medicament for the treatment of acute and chronic soft tissue injury.
5. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for the treatment of knee joint pain.
6. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for the treatment of lumbar muscle strain.
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