CN108261487B - Analgesic Chinese medicinal composition and analgesic plaster and analgesic patch prepared from the same - Google Patents
Analgesic Chinese medicinal composition and analgesic plaster and analgesic patch prepared from the same Download PDFInfo
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- CN108261487B CN108261487B CN201810073420.0A CN201810073420A CN108261487B CN 108261487 B CN108261487 B CN 108261487B CN 201810073420 A CN201810073420 A CN 201810073420A CN 108261487 B CN108261487 B CN 108261487B
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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Abstract
The invention discloses an analgesic traditional Chinese medicine composition and analgesic plaster and a preparation method thereof, wherein the analgesic composition comprises the following components in parts by weight: 20-40 parts of raw pinellia ternate, 20-40 parts of raw arisaema, 20-40 parts of raw radix aconiti kusnezoffii, 20-40 parts of raw radix aconiti brachypodi, 20-40 parts of lycopodium clavatum, 20-40 parts of garden balsam stem, 10-15 parts of radix clematidis, 10-15 parts of ricepaper pith, 5-15 parts of sappan wood, 10-15 parts of frankincense, 10-15 parts of myrrh and 20-40 parts of camphor. Raw pinellia ternate, raw arisaema consanguineum, raw radix aconiti and raw radix aconiti kusnezoffii tetrastigma powder are used as basic prescription, raw aconitum szechenyianum and alpine yarrow herb are added, and then lycopodium clavatum, garden balsam stem, radix clematidis, ricepaper pith, sappan wood, frankincense, myrrh and camphor are used as auxiliary materials.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to an analgesic traditional Chinese medicine composition and analgesic plaster prepared from the same.
Background
At present, the traditional Chinese medicine preparation for easing pain is few, the traditional oral decoction is long in decoction time and poor in taste, and a certain part of patients do not accept the decoction due to the trouble of decoction and the taste problem of the medicine, so that the popularization and the treatment effect of the decoction are retarded to a certain extent. The traditional ointment has low absorption efficiency on the epidermis and is difficult to reach the focus, so the curative effect of the medicine is poor, and the analgesic of the epidermal medicine rarely appears, however, the Chinese medical scientists have a speech of: the plaster can treat diseases, and can be used as a decoction for treating diseases in a very short time. It is clear that the application of the plaster in China has been well established, and the curative effect is well accepted. However, the traditional external application method is inconvenient to clean, and causes problems of local allergy and the like. The application of the four-component powder is limited to a certain extent. The improved preparation technology of the water paste should avoid the defects of the existing external products and decoction. Nowadays, with the development of medical science and technology, the technical problem of improvement of the water paste preparation technology is overcome step by step, and the conditions for preparing and improving the improved water paste are sufficient. And the novel water paste is still relatively rare in the market.
Disclosure of Invention
In order to solve the above technical problems, an object of the present invention is to provide an analgesic Chinese medicinal composition having analgesic effect.
In order to achieve the purpose, the technical scheme of the invention is as follows: an analgesic traditional Chinese medicine composition comprises the following components in parts by weight: 20-40 parts of raw pinellia ternate, 20-40 parts of raw arisaema, 20-40 parts of raw radix aconiti kusnezoffii, 20-40 parts of raw radix aconiti brachypodi, 20-40 parts of lycopodium clavatum, 20-40 parts of garden balsam stem, 10-15 parts of radix clematidis, 10-15 parts of ricepaper pith, 5-15 parts of sappan wood, 10-15 parts of frankincense, 10-15 parts of myrrh and 20-40 parts of camphor.
The technical scheme has the beneficial effects that the raw pinellia tuber, the raw arisaema tuber, the raw common monkshood mother root and the raw kusnezoff monkshood root tetrastigma powder are used as a basic prescription, the raw short-pedicel aconite root and the raw shortstalk monkshood root are added, and then the common clubmoss herb, the garden balsam stem, the clematis root, the ricepaper pith, the sappan wood, the frankincense, the myrrh and the camphor are
In the technical scheme, the paint comprises the following components in parts by weight: 30 parts of raw pinellia ternate, 30 parts of raw arisaema consanguineum, 30 parts of raw radix aconiti agrestis, 30 parts of raw radix aconiti brachypodi, 30 parts of lycopodium clavatum, 30 parts of garden balsam stem, 12 parts of radix clematidis, 12 parts of ricepaper pith, 10 parts of sappan wood, 12 parts of frankincense, 12 parts of myrrh and 30 parts of camphor.
The technical scheme has the beneficial effects that the proportion of each component is moderate, so that the curative effect is more suitable.
The invention also aims to provide the analgesic plaster prepared from the analgesic traditional Chinese medicine composition, which is convenient to use.
In order to achieve the purpose, the technical scheme of the invention is as follows: the preparation method of the analgesic plaster comprises the traditional Chinese medicine composition, and comprises the following steps:
1) weighing 20-40 parts of raw pinellia ternate, 20-40 parts of raw arisaema, 20-40 parts of raw radix aconiti kusnezoffii, 20-40 parts of raw aconitum szechenyianum, 20-40 parts of lycopodium clavatum, 20-40 parts of garden balsam stem, 10-15 parts of radix clematidis, 10-15 parts of ricepaperplant pith, 5-15 parts of sappan wood, 10-15 parts of frankincense, 10-15 parts of myrrh, 20-40 parts of camphor, 20-60 parts of glycerol, 0.2-2 parts of sodium benzoate and 10-60 parts of sodium carboxymethylcellulose;
2) grinding rhizoma Pinelliae, rhizoma arisaematis, radix Aconiti Kusnezoffii and radix Aconiti Brachypodi into powder;
3) immersing the powder obtained in the step 2) in 100-200 parts of 95% medical alcohol for 30min, and separating the immersed medicine residue from the immersion liquid;
4) taking the medicine residues separated in the step 3), common clubmoss herb, garden balsam stem, clematis root, ricepaper pith, sappan wood, frankincense and myrrh, adding 2000 parts of water for decocting, concentrating until the liquid medicine is half of the total volume before decocting, taking out the medicine residues, and keeping the decoction;
5) placing camphor into the soak solution obtained in the step 3) for dissolving;
6) mixing the decoction obtained in the step 4) and the solution obtained in the step 5), heating in a water bath at 50-60 ℃, and concentrating until the total volume of the solution before water bath is 1/3-1/2;
7) placing the concentrated solution obtained in the step 6), 20-60 parts of glycerol and 0.2-2 parts of sodium benzoate in a beaker, quickly stirring and uniformly mixing, heating in a water bath to dissolve the glycerol until the color of the mixed solution is uniform and no obvious particle substances exist, then cooling, adding 10-60 parts of total sodium carboxymethylcellulose in batches when the temperature of the mixed solution is reduced to below 50 ℃, stirring while adding, continuously adding the residual amount when the previous sodium carboxymethylcellulose is fully dissolved in the mixed solution, continuously and quickly stirring for 3min, and then placing in a water bath ultrasonic oscillator for ultrasonic treatment for 30min to obtain the paste.
The technical scheme has the beneficial effects that the raw pinellia ternate, the raw arisaema consanguineum schott, the raw radix aconiti agrestis and the raw short-pedicel aconite root are soaked in the medical alcohol for attenuation, then the medical alcohol is mixed with the rest components except the camphor for decoction and concentration, then the camphor is dissolved by the used medical alcohol, the reasonable utilization of resources is realized, and meanwhile, the active ingredients soaked in the medical alcohol can be reasonably utilized.
The invention also aims to provide the application of the plaster prepared by the method as a coating agent for epidermis.
The invention also aims to provide an analgesic plaster, which comprises a pasting adhesive plaster and the plaster prepared by the method, wherein the plaster is uniformly coated on the surface of the pasting adhesive plaster.
The coating weight of the paste in the technical scheme is 0.2-1g/cm2。
1. The invention strengthens the traditional Chinese medicines for dispelling wind, removing dampness, promoting blood circulation and relieving pain on the basis of the original four-element powder, so as to further improve the effects of dispelling wind, removing obstruction of vital energy in channels, promoting blood circulation and removing blood stasis, and play an active role in treating old soft tissue injury and anemofrigid-damp arthralgia.
2. On the basis of the original Sisheng powder, radix aconiti brachypodi is added to further strengthen the power of removing rheumatism, promoting blood circulation and relieving pain.
3. Olibanum and Myrrha can be added to promote blood circulation, relieve pain, relieve swelling and promote granulation.
4. Herba Lycopodii and herba speranskiae tuberculatae can be added to relax muscles and tendons, dredge collaterals, dispel wind, and relieve arthralgia.
5. Radix Clematidis and lignum sappan are added to promote qi and blood circulation, remove blood stasis and relieve pain.
6. Medulla Tetrapanacis is added to clear heat and promote diuresis.
7. Adding Camphora to remove dampness, kill parasite, warm channels and relieve pain
Detailed Description
The principles and features of this invention are described below in conjunction with examples which are set forth to illustrate, but are not to be construed to limit the scope of the invention.
Example 1
The embodiment provides an analgesic traditional Chinese medicine composition which comprises the following components in parts by weight: 20-40 parts of raw pinellia ternate, 20-40 parts of raw arisaema, 20-40 parts of raw radix aconiti kusnezoffii, 20-40 parts of raw radix aconiti brachypodi, 20-40 parts of lycopodium clavatum, 20-40 parts of garden balsam stem, 10-15 parts of radix clematidis, 10-15 parts of ricepaper pith, 5-15 parts of sappan wood, 10-15 parts of frankincense, 10-15 parts of myrrh and 20-40 parts of camphor.
Preferably, the analgesic component comprises the following components in parts by weight: 30 parts of raw pinellia ternate, 30 parts of raw arisaema consanguineum, 30 parts of raw radix aconiti agrestis, 30 parts of raw radix aconiti szechenyiani, 30 parts of lycopodium clavatum, 30 parts of garden balsam stem, 12 parts of radix clematidis, 12 parts of ricepaper pith, 10 parts of sappan wood, 12 parts of frankincense, 12 parts of myrrh and 30 parts of camphor.
Example 2
The embodiment provides a preparation method of an analgesic plaster, which comprises the above traditional Chinese medicine composition, and the preparation method comprises the following steps:
1) weighing 20 parts of unprocessed pinellia tuber, 20 parts of unprocessed arisaema consanguineum schott, 20 parts of unprocessed monkshood, 20 parts of unprocessed kusnezoff monkshood root, 20 parts of unprocessed radix aconiti kusnezoffii, 20 parts of common clubmoss herb, 20 parts of garden balsam stem, 10 parts of clematis root, 10 parts of ricepaperplant pith, 5-15 parts of sappan wood, 10 parts of frankincense, 10 parts of myrrh, 20 parts of camphor, 20 parts of glycerin, 0.2 part of sodium benzoate and 10 parts of sodium carboxymethylcellulose; wherein, the glycerol, the sodium benzoate and the sodium carboxymethyl cellulose are all auxiliary materials for preparing the ointment.
2) Grinding rhizoma Pinelliae, rhizoma arisaematis, radix Aconiti Kusnezoffii and radix Aconiti Brachypodi into powder;
3) immersing the powder obtained in the step 2) in 100 parts of 95% medical alcohol for 30min, and separating the immersed dregs from the immersion liquid;
4) taking the medicine residues separated in the step 3), lycopodium clavatum, garden balsam stem, clematis root, ricepaper pith, sappan wood, frankincense and myrrh, adding 1500 parts of water, decocting, concentrating until the liquid medicine is half of the total volume before decoction, taking out the medicine residues, and keeping the decoction;
5) placing camphor into the soak solution obtained in the step 3) for dissolving;
6) mixing the decoction obtained in the step 4) and the solution obtained in the step 5), and then heating in a water bath for concentration until the total volume of the solution is 1/3 of the total volume before the water bath;
7) placing the concentrated solution obtained in the step 6), glycerol and sodium benzoate into a beaker, quickly stirring and uniformly mixing, heating in a water bath to dissolve the concentrated solution until the mixed solution is uniform in color and free of obvious particulate matters, then cooling, adding 10 parts of sodium carboxymethylcellulose in the total amount of the carboxyl in batches when the temperature of the mixed solution is reduced to below 50 ℃, stirring while adding, continuing to add the residual amount after the previous sodium carboxymethylcellulose is fully dissolved in the mixed solution when adding, continuing to quickly stir for 3min, and then placing into a water bath ultrasonic oscillator to perform ultrasonic treatment for 30min to obtain the paste.
Example 3
The embodiment provides a preparation method of an analgesic plaster, which comprises the above traditional Chinese medicine composition, and the preparation method comprises the following steps:
1) weighing 30 parts of raw pinellia ternate, 30 parts of raw arisaema consanguineum, 30 parts of raw radix aconiti, 30 parts of raw kusnezoff monkshood root, 30 parts of raw short-pedicel aconite root, 30 parts of common clubmoss herb, 30 parts of garden balsam stem, 12.5 parts of radix clematidis, 12.5 parts of ricepaperplant pith, 10 parts of sappan wood, 12.5 parts of frankincense, 12.5 parts of myrrh, 30 parts of camphor, 40 parts of glycerol, 1 part of sodium benzoate and 35 parts of sodium carboxymethylcellulose;
2) grinding rhizoma Pinelliae, rhizoma arisaematis, radix Aconiti Kusnezoffii and radix Aconiti Brachypodi into powder;
3) immersing the powder obtained in the step 2) in 150 parts of 95% medical alcohol for 30min, and separating the immersed dregs from the immersion liquid;
4) adding 1750 parts of water into the medicine residues separated in the step 3), the common clubmoss herb, the garden balsam stem, the clematis root, the ricepaper pith, the sappan wood, the frankincense and the myrrh, decocting, concentrating until the medicine liquid is half of the total volume before decoction, fishing out the medicine residues, and keeping the decoction liquid;
5) placing camphor into the soak solution obtained in the step 3) for dissolving;
6) mixing the decoction obtained in the step 4) and the solution obtained in the step 5), heating in a water bath at 50-60 ℃, and concentrating to 2/5 of the total volume of the solution before water bath;
7) placing the concentrated solution obtained in the step 6), glycerol and sodium benzoate into a beaker, quickly stirring and uniformly mixing, heating in a water bath to dissolve the concentrated solution until the color of the mixed solution is uniform and no obvious particulate matter exists, then cooling, adding sodium carboxymethylcellulose in portions when the temperature of the mixed solution is reduced to below 50 ℃, stirring while adding, when adding, continuously adding the remainder after the previous sodium carboxymethylcellulose is fully dissolved in the mixed solution, continuously and quickly stirring for 3min, and then placing into a water bath ultrasonic oscillator for ultrasonic treatment for 30min to obtain the paste.
Example 4
The embodiment provides a preparation method of an analgesic plaster, which comprises the above traditional Chinese medicine composition, and the preparation method comprises the following steps:
1) weighing 40 parts of raw pinellia ternate, 40 parts of raw arisaema consanguineum, 40 parts of raw radix aconiti agrestis, 40 parts of raw short-pedicel aconite root, 40 parts of common clubmoss herb, 40 parts of garden balsam stem, 15 parts of radix clematidis, 15 parts of ricepaper pith, 15 parts of sappan wood, 15 parts of frankincense, 15 parts of myrrh, 40 parts of camphor, 60 parts of glycerol, 2 parts of sodium benzoate and 60 parts of sodium carboxymethylcellulose;
2) grinding rhizoma Pinelliae, rhizoma arisaematis, radix Aconiti Kusnezoffii and radix Aconiti Brachypodi into powder;
3) immersing the powder obtained in the step 2) in 200 parts of 95% medical alcohol for 30min, and separating the immersed dregs from the immersion liquid;
4) decocting the medicinal residues separated in the step 3) and herba lycopodii, speranskia tuberculata, radix clematidis, ricepaperplant pith, sappan wood, frankincense and myrrh by adding 2000 parts of water, concentrating until the total volume of the medicinal liquid is half of the total volume before decoction, taking out the medicinal residues, and keeping the decoction;
5) placing camphor into the soak solution obtained in the step 3) for dissolving;
6) mixing the decoction obtained in the step 4) and the solution obtained in the step 5), and then heating in a water bath for concentration until the total volume of the solution is 1/2 of the total volume before the water bath;
7) placing the concentrated solution obtained in the step 6), glycerol and sodium benzoate into a beaker, quickly stirring and uniformly mixing, heating in a water bath to dissolve the concentrated solution until the color of the mixed solution is uniform and no obvious particulate matter exists, then cooling, adding sodium carboxymethylcellulose in portions when the temperature of the mixed solution is reduced to below 50 ℃, stirring while adding, when adding, continuously adding the remainder after the previous sodium carboxymethylcellulose is fully dissolved in the mixed solution, continuously and quickly stirring for 3min, and then placing into a water bath ultrasonic oscillator for ultrasonic treatment for 30min to obtain the paste.
Example 5
The ointments corresponding to examples 2 to 4 were used as skin-applied agents.
Example 6
This example provides an analgesic patch, which is prepared by applying nine adhesive tapes to the corresponding plasters of examples 2-4 in a coating amount of 0.2g/cm2、0.6g/cm2、1g/cm2Uniformly coating on the corresponding surface of the pasting rubberized fabric.
Animal experiments
Note that: the plaster corresponding to example 3 was used as an experimental drug in the animal experimental group.
1. The experimental method comprises the following steps: mouse ear swelling test. The anaphylactic reaction caused by the traditional Chinese medicine external preparation is usually type IV hypersensitivity reaction which is generally clinically manifested as allergic contact dermatitis. In the mouse ear swelling test, the auricle of the mouse is used as a target site of dermatitis, and the irritation of the medicament to the skin of the mouse is judged according to the color and thickness of the auricle and the number of inflammatory cells per unit area. The method has the characteristics of simple operation, objective test result, low experiment cost and the like.
2. Subject: 6-month old white mice (30-35g) that substantially reached sexual maturity to mimic adult skin.
3. The concrete steps
(1) And (3) experimental operation: selecting a standard white rat to carry out simple unhairing treatment, exposing experimental skin, sucking a small amount of water cream to be uniformly smeared on an exposed auricle part, slightly kneading auricles, promoting blood circulation of the auricle part, promoting absorption of effective components of the water cream, putting the water cream to be smeared into a sterile incubator to observe when the water cream loses lubricity, cleaning dry residues once a day when the next operation is carried out, and carrying out experimental treatment for 7 d. The experiment adopts a control experiment, 15 groups are externally coated with the aqua cream, and 10 groups are not externally coated with the aqua cream. The two groups of experimental white mice belong to the same batch breeding, the growth and cultivation conditions are basically the same, and the living and growing environments of the two groups of experimental white mice are the same except for different control items during the experiment.
(2) Evaluation criteria: firstly, carrying out visual observation, and judging whether the auricle of the externally-applied mouse has inflammatory reactions such as redness and swelling; then pricking two groups of mouse auricles, taking blood, and detecting the difference of blood inflammatory cells of the two groups of mouse auricles.
(3) And (3) test results: the auricle of the externally applied mouse has no obvious red swelling, and the vital signs of the mouse are not different from those of the control group. The white blood cell count of the external application group does not exceed the white blood cell count of normal mice in blood examination or 5 percent compared with the white blood cell count of the mice in the control group.
Clinical experiments
Note that: the plaster corresponding to example 3 was used as an experimental drug in the animal experimental group.
And negotiating with a traditional Chinese medical hospital on the premise of ensuring that the sensitization experiment meets clinical standards, and carrying out a staged grouping experiment on the premise of instructing by a clinician and agreeing by a patient. The test subjects of the powder group for external use (control group) and the plaster application group (treatment group) are from 1 day 10 in 2017 to 1 day 4 in 2018, and the acceptance of old soft tissue injury cases in medical institutions in Baoding City.
1. Purpose of the experiment: the clinical treatment condition of the analgesic plaster on the old soft tissue injury is observed, so that the effect of the analgesic plaster is determined, and the feasibility and the effective rate of the plaster are detected.
2. The research content is as follows: from 2017, month 10, day 1 to 2018, month 4, day 1, 90 patients within 18-65 years of age were selected and clinical patients were randomly applied with the above-mentioned group treatment. The number of persons of the same or nearly the same amount was randomly selected from the above-mentioned groups and followed by observation and follow-up, and the degree of reduction of clinical symptoms, the time of reduction or disappearance, and the presence or absence of repetition of each group were counted and analyzed by a statistical method. Thereby judging which using method has better clinical effect.
3. The research requirements are as follows:
(1) the diagnostic requirements are:
old soft tissue injuries include cases: among them, 18 cases of scapulohumeral periarthritis, 18 cases of tennis elbow, 18 cases of lumbar sprain and lumbar muscle strain, 18 cases of ankle sprain and 18 cases of knee joint sprain.
Before the experiment of the candidate, the patient is selected according to the clinical diagnosis, and is suitable for and receives conservative treatment; both groups of patients should follow the rule of work and rest; the control group and the treatment group have no special requirements and no treatment difference except for different dosage forms.
The evaluation standard of curative effect is as follows:
and (3) curing: the local pain and swelling disappear, the joint movement returns to normal, and no relapse occurs after 1 month of follow-up visit.
The effect is shown: the local pain and swelling are obviously reduced, and the joint movement is basically normal.
The method has the following advantages: local pain and swelling are improved, and joint movement is improved.
The using method comprises the following steps: the liniment is applied to the affected part, and is administered in combination with manipulation of tuina for 3min, so that the ointment can be absorbed completely, and the applied part has less residual ointment and is easy to clean. The application agent is applied on the acupoint according to symptoms for more than 4 h. Pain can be severe twice a day and pain can be tolerated once a day. 7 days are taken as a treatment course, and the results are counted after 4 treatment courses.
The treatment results are as follows:
1. scapulohumeral periarthritis: 8 cases are cured, the obvious effect is 7, and 3 cases are effective;
2. tennis elbow: 7 cases are cured, 6 cases are obviously effective, and 5 cases are effective;
3. lumbar sprain and lumbar muscle strain; 12 cases are cured, and 6 cases are obviously effective;
4. ankle sprain: 16 cases are cured, 1 case is obviously effective, and 1 case is effective;
5. sprain of the knee joint: 14 cases are cured, 3 cases are obviously effective, and 1 case is effective.
In the above examples, camphor is used as a transdermal agent which is mainly used for enhancing the transdermal function of the medicinal components,
selection of auxiliary material for pain-relieving plaster and pain-relieving plaster
The formula is as follows: 30g of raw pinellia tuber, raw arisaema, raw kusnezoff monkshood root, raw common monkshood mother root and raw short-pedicel aconite root respectively, 12g of frankincense, 12g of myrrh, 30g of common clubmoss herb, 30g of garden balsam stem, 30g of clematis root, 10g of sappan wood and 12g of beautiful sweetgum fruit, and 286g of traditional Chinese medicinal materials are counted.
1. Coating agent
2. Plaster application agent
Second, transdermal agent assay
0.30% of borneol, camphor, 0.20% of azone, propylene glycol and oleic acid are selected for testing, and the best one is selected as the transdermal agent.
Selecting 30 parts of raw pinellia tuber, 30 parts of raw arisaema consanguineum, 30 parts of raw monkshood, 30 parts of raw kusnezoff monkshood root, 30 parts of raw shortstalk monkshood root, 30 parts of common clubmoss herb, 30 parts of garden balsam stem, 12 parts of clematis root, 12 parts of ricepaper pith, 10 parts of sappan wood, 12 parts of frankincense, 12 parts of myrrh and 12 parts of camphor as blank groups, simultaneously respectively setting five groups on the basis of the blank groups, respectively adding 0.30 percent of borneol, camphor, 0.20 percent of azone, propylene glycol and oleic acid with the same dosage, respectively carrying out ultraviolet spectroscopy experiments on the six groups of data, and detecting the relation of the absorbance along with the change of time as shown in:
| transdermal agent | 0.5h | 1h | 1.5h | 2h | 4h | 6h |
| Water paste | 0.108 | 0.118 | 0.131 | 0.136 | 0.156 | 0.325 |
| 0.30% borneol | 0.113 | 0.125 | 0.157 | 0.180 | 0.256 | 0.418 |
| Camphor | 0.120 | 0.143 | 0.167 | 0.208 | 0.356 | 0.509 |
| 0.20% azone | 0.122 | 0.124 | 0.146 | 0.180 | 0.220 | 0.402 |
| Propylene glycol | 0.100 | 0.111 | 0.145 | 0.154 | 0.217 | 0.425 |
| Oleic acid | 0.119 | 0.142 | 0.175 | 0.193 | 0.266 | 0.448 |
2. Transdermal enhancement rate
The results of the transdermal tests performed on the above six groups of tests were as follows:
the data show that the transdermal effect of camphor is most pronounced at equivalent dosages under equivalent conditions.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (5)
1. The preparation method of the analgesic plaster is characterized by comprising the following steps:
1) weighing 20-40 parts of raw pinellia ternate, 20-40 parts of raw arisaema, 20-40 parts of raw radix aconiti kusnezoffii, 20-40 parts of raw aconitum szechenyianum, 20-40 parts of common clubmoss herb, 20-40 parts of garden balsam stem, 10-15 parts of radix clematidis, 10-15 parts of ricepaper pith, 5-15 parts of sappan wood, 10-15 parts of frankincense, 10-15 parts of myrrh and 20-40 parts of camphor according to the weight ratio;
2) grinding rhizoma Pinelliae, rhizoma arisaematis, radix Aconiti Kusnezoffii and radix Aconiti Brachypodi into powder;
3) immersing the powder obtained in the step 2) in 100-200 parts of 95% medical alcohol for 30min, and separating the immersed medicine residue from the immersion liquid;
4) taking the medicine residues separated in the step 3), common clubmoss herb, garden balsam stem, clematis root, ricepaper pith, sappan wood, frankincense and myrrh, adding 2000 parts of water for decocting, concentrating until the liquid medicine is half of the total volume before decocting, taking out the medicine residues, and keeping the decoction;
5) placing camphor into the soak solution obtained in the step 3) for dissolving;
6) mixing the decoction obtained in the step 4) and the solution obtained in the step 5), heating in a water bath at 50-60 ℃, and concentrating until the total volume of the solution before water bath is 1/3-1/2;
7) placing the concentrated solution obtained in the step 6), 20-60 parts of glycerol and 0.2-2 parts of sodium benzoate in a beaker, quickly stirring and uniformly mixing, heating in a water bath to dissolve the glycerol until the color of the mixed solution is uniform and no obvious particle substances exist, then cooling, adding 10-60 parts of total sodium carboxymethylcellulose in batches when the temperature of the mixed solution is reduced to below 50 ℃, stirring while adding, continuously adding the residual amount when the previous sodium carboxymethylcellulose is fully dissolved in the mixed solution, continuously and quickly stirring for 3min, and then placing in a water bath ultrasonic oscillator for ultrasonic treatment for 30min to obtain the paste.
2. The preparation method of the analgesic plaster as claimed in claim 1, wherein 30 parts of raw pinellia ternate, 30 parts of raw arisaema consanguineum, 30 parts of raw monkshood, 30 parts of raw kusnezoff monkshood root, 30 parts of raw short-pedicel aconite root, 30 parts of raw shortstalk monkshood root, 30 parts of common clubmoss herb, 30 parts of common speranskia herb, 12 parts of clematis root, 12 parts of ricepaperplant pith, 10 parts of sappan wood, 12 parts of frankincense, 12 parts of myrrh and 30 parts of camphor are weighed according to the weight.
3. A process for the preparation of an analgesic plaster according to claim 1 or 2, characterized in that the plaster is prepared as a topical application.
4. An analgesic patch characterized by comprising a patch and the analgesic patch obtained by the method for producing an analgesic patch according to claim 1 or 2, wherein the patch is uniformly coated on the surface of the patch.
5. The analgesic patch as claimed in claim 4, wherein the amount of the plaster applied is 0.2 to 1g/cm2。
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| 中药外敷四虎散治疗急性腰扭伤20例;刘中民;《中医外治杂志》;20021231;第11卷(第6期);第44-45页 * |
| 四虎散加味治疗痛症;刘世刚等;《中国民间疗法》;20000228;第8卷(第2期);第37-38页 * |
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