CN100540049C - Fibre connexin active tears and production method thereof - Google Patents
Fibre connexin active tears and production method thereof Download PDFInfo
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- CN100540049C CN100540049C CNB2007100547687A CN200710054768A CN100540049C CN 100540049 C CN100540049 C CN 100540049C CN B2007100547687 A CNB2007100547687 A CN B2007100547687A CN 200710054768 A CN200710054768 A CN 200710054768A CN 100540049 C CN100540049 C CN 100540049C
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Abstract
A kind of fibre connexin active tears and production method thereof, feature is lubrication humectant and the slaine hydrochlorate that comprises that fibronectin, macromolecular compound are formed, and is a kind of active tears that is mainly used in other ophthalmic diseasess such as xerophthalmia and keratitis, conjunctivitis, contains pure-natural biological active component fibronectin (FN).The present invention compares with present artificial tears, has outstanding feature, mainly show: the invention belongs to the cytokine class active tears, contain the bioactive substance that extracts in the animal body, and by several macromolecules that have no side effect are composite by a certain percentage, make this active tears have good lubrication, suitable viscosity and water-retaining property, and do not contain antibiotic medicine, life-time service has no side effect, and is a kind of ideal active tears that is used for the treatment of multiple ophthalmic diseasess such as eye cornea inflammation, conjunctivitis, corneal ulcer and is beneficial to eye health.
Description
Technical field
The present invention relates to eye and use medicinal liquid, particularly a kind of fibre connexin active tears is mainly used in other ophthalmic diseasess such as xerophthalmia and keratitis, conjunctivitis, contains the active tears of bioactive ingredients fibronectin (FN).
Background technology
Xerophthalmia becomes one of modal eye surface diseases in recent years, is usually expressed as eyes fatiguability, foreign body sensation, sensation of dryness, burn feeling, the bloated sense of acid, with ophthalmic pruritus, photophobia, blurred vision and eye hyperemia.If long-term dry, can not get effective treatment, then can form cornea, conjunctiva keratinization, ulcer, scab etc., cause the decline of vision, the danger of blinding is arranged when serious.Along with the universal prosperity of computer and network, prevalence has the trend that rises year by year, and patient's the tendency that becomes younger is very obvious, has had a strong impact on people's work efficient and health.The treatment of xerophthalmia is subjected to global great attention.
Preventing clinically and treating xerophthalmia has many methods, and main strategy is to replenish the tear composition and reduce tear to run off.Wherein the artificial tears is a kind of medicament for the eyes that imitates the human body tear.Because its physicochemical property is similar to the tear film, can keep or improve eye table humidity and lubricate, eliminate or alleviate ophthalmic uncomfortable, so be generally used for one of measure that local eye dripping treats as an alternative.Artificial tears's dosage form comprises aqueous solution, oil solution, gel and eye ointment etc.Wherein lubricated humidity-preserving type is artificial tears's a main dosage form, comprises methylcellulose class, hyaluronic acid sodium class, polyacrylic, polyethylene kind etc.The tear of these dosage forms increases the stability of tear film by improving viscosity, water-retaining property etc.But there is shortcoming separately in they, can cause blurred vision as heavy-gravity liquid behind the methylcellulose class eye dripping, and the polyethylene kind viscosity is low, and are short in eye table retention time, need frequent eye dripping can keep effect.
Can be divided into antibiotics, vitamins and cytokine class etc. by the effective ingredient artificial tears.And appropriate for a long time, abuse of antibiotics, not only bad for the treatment disease of eye, also can increase the weight of the xerophthalmia state of an illness.The effect that vitamins and cytokine class have nutrition and improve the organism metabolism function will be artificial tears's a developing direction.
Summary of the invention
Purpose of the present invention is just at above-mentioned existing in prior technology problem and a kind of fibre connexin active tears of special development, the present invention contains the bioactive substance that extracts in the animal body, and by several macromolecules that have no side effect are composite by a certain percentage, make it have good lubrication, suitable viscosity and water-retaining property, and do not contain antibiotic medicine, life-time service has no side effect, and is a kind of ideal active tears that is used for the treatment of multiple ophthalmic diseasess such as eye cornea inflammation, conjunctivitis, corneal ulcer and is beneficial to eye health.
The objective of the invention is to realize by following scheme: fibre connexin active tears of the present invention comprises lubrication humectant and the slaine hydrochlorate that fibronectin, macromolecular compound are formed, and is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.1～1.0g
Carbomer and/or polyvinyl alcohol 0.1～1.8g
Boric acid 0.3～0.5g
Slaine Barbiturates 0.6～1.2g
Fibronectin 0.01～0.1g
Transfer pH6.5～7.0 with sodium bicarbonate,
Add pure water to 100ml.
In the present invention, described slaine hydrochlorate can be any one or its combination in sodium chloride, potassium chloride, magnesium chloride, calcium chloride, the zinc chloride.Described hydroxyethyl-cellulose can be substituted by similar materials such as hydroxypropyl emthylcellulose or sodium carboxymethyl cellulose.The purpose that adds boric acid is the boron element that can increase tear.
In said components, hydroxyethyl-cellulose, carbomer, polyvinyl alcohol can be used for three kinds simultaneously, but also hydroxyethyl-cellulose, carbomer are used for two kinds simultaneously, or hydroxyethyl-cellulose, polyvinyl alcohol use for two kinds simultaneously, all can reach purpose of the present invention.
Fibre connexin active tears of the present invention is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.1～1.0g
Carbomer 0.1～0.8g
Polyvinyl alcohol 0.1～1.0g
Boric acid 0.3～0.5g
Sodium chloride 0.6～0.9g
Potassium chloride 0.15～0.2g
Magnesium chloride 0.005g
Fibronectin 0.01～0.1g,
Transfer pH6.5～7.0 with sodium bicarbonate,
Add pure water to 100ml.
The concrete component proportioning of fibre connexin active tears of the present invention can be as follows: hydroxyethyl-cellulose 0.8g, carbomer 0.4g, boric acid 0.35g, sodium chloride 0.8g, potassium chloride 0.15g, magnesium chloride 0.003g, fibronectin 0.08g transfers pH6.5～7.0 with sodium bicarbonate, adds pure water to 100ml.
The concrete component proportioning of fibre connexin active tears of the present invention also can be as follows: hydroxyethyl-cellulose 0.4g, carbomer 0.6g, polyvinyl alcohol 0.2g, boric acid 0.4g, sodium chloride 0.8g, potassium chloride 0.2g, magnesium chloride 0.005g, fibronectin 0.1g transfers pH6.5～7.0 with sodium bicarbonate, adds pure water to 100ml.
Following component proportioning also can reach purpose of the present invention: hydroxyethyl-cellulose 0.4g, polyvinyl alcohol 0.6g, boric acid 0.4g, sodium chloride 0.8g, potassium chloride 0.2g, magnesium chloride 0.005g, fibronectin 0.08g transfers pH6.5～7.0 with sodium bicarbonate, adds pure water to 100ml.
The production method of fibre connexin active tears of the present invention is as follows: hydroxyethyl-cellulose, carbomer and/or polyvinyl alcohol respectively by after prescription consumption weighing and adding suitable quantity of water and dissolve fully, are filtered.Other belongs to hydrochlorate by depletion and boric acid is dissolved in an amount of hot water, filters.The two is mixed the back transfer pH6.5～7.0 with sodium bicarbonate, add pure water to setting volume, carry out pasteurization, the cooling back is pressed formula ratio and is added fibronectin, after the magnetic agitation, carries out the degerming of microfiltration secondary, the aseptic subpackaged product that promptly gets.
The present invention has overcome artificial tears's shortcoming in the market, mainly show as: the one, the present invention utilizes the lubrication humectant of two or more macromolecular compound (hydroxyethyl-cellulose, carbomer, polyvinyl alcohol) as tear, stability improves greatly; The 2nd, the present invention has used the natural bioactive ingredients fibronectin, and this at home and external all beyond examples.The fibronectin raw material was applied for Chinese patent by our company in 2005.Obtain invention patent certificate, the patent No.: ZL 2,005 10017717.8 in January, 2007.
Fibronectin (Fibronectin) is a kind of macromolecule glycoprotein that extensively is present in animal tissue and the tissue fluid, and sugar content accounts for 5-9%, is mainly oligosaccharide, and sugar plays the digestion hydrolysis that the protection fibronectin exempts from protease.The fibronectin relative molecular mass is about 450KD, is connected to form by interchain disulfide bond by the subunit of two about 230KD of molecular weight.In the body vital movement, fibronectin participated in cell adhesion, sprawl, breed, migration and embryo's growth, also participate in the many pathological processes of body, as wound healing, inflammation, fibre modification etc.
The present invention has the character of natural tears, can combine with tear, action temperature and, rapidly and alleviate xerophthalmia, allergy and irritation etc. constantly.Life-time service has no side effect, and can be used for treating multiple ophthalmic diseases and eye healths such as eye cornea inflammation, conjunctivitis, corneal ulcer, is a kind of ideal activity tear.The present invention adds the direction that the fibronectin with multiple biological function has been represented artificial tears's development.
The specific embodiment
The present invention is described further below in conjunction with embodiment, but does not limit the present invention.
Embodiment 1
Fibre connexin active tears is made up of the component of following consumption proportion: hydroxyethyl-cellulose 0.8g, carbomer 0.4g, boric acid 0.35g, sodium chloride 0.8g, potassium chloride 0.15g, magnesium chloride 0.003g, fibronectin 0.08g, transfer pH6.5～7.0 with sodium bicarbonate, add pure water to 100ml.
Production method is as follows: after hydroxyethyl-cellulose, carbomer are added suitable quantity of water (pure water) and dissolve fully, filter.Other gets sodium chloride, potassium chloride, magnesium chloride and boric acid and is dissolved in an amount of hot water (pure water), filters.The two is mixed the back transfer pH6.5～7.0 with sodium bicarbonate, add pure water to setting volume, carry out pasteurization, the cooling back is pressed formula ratio and is added fibronectin, after the magnetic agitation, carries out the degerming of microfiltration secondary, the aseptic subpackaged product that promptly gets.
Embodiment 2
Fibre connexin active tears of the present invention can also be made up of the component of following consumption proportion: hydroxyethyl-cellulose 0.4g, carbomer 0.6g, polyvinyl alcohol 0.2g, boric acid 0.4g, sodium chloride 0.8g, potassium chloride 0.2g, magnesium chloride 0.005g, fibronectin 0.1g transfers pH6.5～7.0 with sodium bicarbonate, adds pure water to 100ml.
Production method is as follows: after hydroxyethyl-cellulose, carbomer, polyvinyl alcohol are added suitable quantity of water (pure water) and dissolve fully, filter.Other gets sodium chloride, potassium chloride, magnesium chloride and boric acid and is dissolved in an amount of hot water (pure water), filters.The two is mixed the back transfer pH6.5～7.0 with sodium bicarbonate, add pure water to setting volume, carry out pasteurization, the cooling back is pressed formula ratio and is added fibronectin, after the magnetic agitation, carries out the degerming of microfiltration secondary, the aseptic subpackaged product that promptly gets.
Embodiment 3
Following prescription also can reach purpose of the present invention: hydroxyethyl-cellulose 0.4g, polyvinyl alcohol 0.6g, boric acid 0.4g, sodium chloride 0.8g, potassium chloride 0.2g, magnesium chloride 0.005g, fibronectin 0.1g transfers pH6.5～7.0 with sodium bicarbonate, adds pure water to 100ml.
Production method is as follows: after hydroxyethyl-cellulose, polyvinyl alcohol are added suitable quantity of water (pure water) and dissolve fully, filter.Other gets sodium chloride, potassium chloride, magnesium chloride and boric acid and is dissolved in an amount of hot water (pure water), filters.The two is mixed the back transfer pH6.5～7.0 with sodium bicarbonate, add pure water to setting volume, carry out pasteurization, the cooling back is pressed formula ratio and is added fibronectin, after the magnetic agitation, carries out the degerming of microfiltration secondary, the aseptic subpackaged product that promptly gets.
In the above-described embodiments, also can corresponding interpolation calcium chloride or zinc chloride, addition is 0.005g.
The present invention also can be combined into various embodiments according to formula range, also all can reach use therapeutic effect of the present invention, repeats no more.
Claims (10)
1, a kind of fibre connexin active tears is characterized in that: it comprises lubrication humectant and the slaine hydrochlorate that fibronectin, macromolecular compound are formed, and is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.1～1.0g
Carbomer and/or polyvinyl alcohol 0.1～1.8g
Boric acid 0.3～0.5g
Slaine Barbiturates 0.6～1.2g
Fibronectin 0.01～0.1g
Transfer pH6.5～7.0 with sodium bicarbonate
Add pure water to 100ml.
2, fibre connexin active tears according to claim 1 is characterized in that: the slaine hydrochlorate is sodium chloride, potassium chloride, magnesium chloride, calcium chloride, zinc chloride any one or its combination.
3, fibre connexin active tears according to claim 1 is characterized in that: hydroxyethyl-cellulose can be substituted by hydroxypropyl emthylcellulose or sodium carboxymethyl cellulose.
4, fibre connexin active tears according to claim 1 and 2 is characterized in that: this active tears is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.1～1.0g
Carbomer 0.1～0.8g
Polyvinyl alcohol 0.1～1.0g
Boric acid 0.3～0.5g
Sodium chloride 0.6～0.9g
Potassium chloride 0.15～0.2g
Magnesium chloride 0.005g
Fibronectin 0.01～0.1g
Transfer pH6.5～7.0 with sodium bicarbonate
Add pure water to 100ml.
5, fibre connexin active tears according to claim 1 and 2 is characterized in that: this active tears is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.1～1.0g
Carbomer 0.1～0.8g
Boric acid 0.3～0.5g
Sodium chloride 0.6～0.9g
Potassium chloride 0.15～0.2g
Magnesium chloride 0.005g
Fibronectin 0.01～0.1g
Transfer pH6.5～7.0 with sodium bicarbonate,
Add pure water to 100ml.
6, fibre connexin active tears according to claim 1 and 2 is characterized in that: this active tears is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.1～1.0g
Polyvinyl alcohol 0.1～1.0g
Boric acid 0.3～0.5g
Sodium chloride 0.6～0.9g
Potassium chloride 0.15～0.2g
Magnesium chloride 0.005g
Fibronectin 0.01～0.1g
Transfer pH6.5～7.0 with sodium bicarbonate,
Add pure water to 100ml.
7, fibre connexin active tears according to claim 1 and 2 is characterized in that: this active tears is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.8g,
Carbomer 0.4g,
Boric acid 0.35g,
Sodium chloride 0.8g,
Potassium chloride 0.15g,
Magnesium chloride 0.003g,
Fibronectin 0.08g,
Transfer pH6.5～7.0 with sodium bicarbonate,
Add pure water to 100ml.
8, fibre connexin active tears according to claim 1 and 2 is characterized in that: this active tears is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.4g,
Carbomer 0.6g,
Polyvinyl alcohol 0.2g,
Boric acid 0.4g,
Sodium chloride 0.8g,
Potassium chloride 0.2g,
Magnesium chloride 0.005g,
Fibronectin 0.1g,
Transfer pH6.5～7.0 with sodium bicarbonate,
Add pure water to 100ml.
9, fibre connexin active tears according to claim 1 and 2 is characterized in that: this active tears is made up of the component of following consumption proportion:
Hydroxyethyl-cellulose 0.4g,
Polyvinyl alcohol 0.6g,
Boric acid 0.4g,
Sodium chloride 0.8g,
Potassium chloride 0.2g,
Magnesium chloride 0.005g,
Fibronectin 0.1g,
Transfer pH6.5～7.0 with sodium bicarbonate,
Add pure water to 100ml.
10, the production method of the described fibre connexin active tears of a kind of production claim 1 is characterized in that: hydroxyethyl-cellulose, carbomer and/or polyvinyl alcohol respectively by after prescription consumption weighing and adding suitable quantity of water and dissolve fully, are filtered; Other belongs to hydrochlorate by depletion and boric acid is dissolved in an amount of hot water, filters; The two is mixed the back transfer pH6.5～7.0 with sodium bicarbonate, add pure water to setting volume, carry out pasteurization, the cooling back is pressed formula ratio and is added fibronectin, after the magnetic agitation, carries out the degerming of microfiltration secondary, the aseptic subpackaged product that promptly gets.
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| CNB2007100547687A CN100540049C (en) | 2007-07-13 | 2007-07-13 | Fibre connexin active tears and production method thereof |
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| CNB2007100547687A CN100540049C (en) | 2007-07-13 | 2007-07-13 | Fibre connexin active tears and production method thereof |
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