CN105999213A - Preparation method of giant salamander skin ointment for repairing human skin - Google Patents
Preparation method of giant salamander skin ointment for repairing human skin Download PDFInfo
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract
The invention provides a giant salamander skin ointment for repairing human skin and a preparation method thereof. The giant salamander skin ointment is prepared from, by weight, 30-40 parts of giant salamander skin protein powder, 15-20 parts of giant salamander skin mucus protein powder, 50-60 parts of rapeseed oil, 5-10 parts of borneol, 5-10 parts of aloe, 5-10 parts of mint and 5-10 parts of honey. Damaged skin tissue and cells can be rapidly repaired.
Description
Technical field
The invention belongs to skin care technical field, relate to a kind of skin repair unguentum, be specifically related to a kind of Andrias davidianus Blanchard skin human body skin and repair unguentum and preparation method thereof.
Background technology
Andrias davidianus Blanchard, is commonly called as Megalobatrachus japonicus daoidianuas (Blanchard), belongs to amphibian Caudata Cryptobranchidae, is the most precious Amphibian of the existing maximum in the world, the national two aquatic wild protection animals of class, agriculture industrialization and featured agriculture exploitation kind, wild animal gene protection kind.Andrias davidianus Blanchard is distributed widely in Shaanxi, Jiangxi, Sichuan, Hunan, Hubei etc.
17
Provinces and regions.Because its delicious meat is fertile, flavour is delicious, and containing nutrient substance such as a large amount of protein, essential amino acids, unsaturated fatty acid and mineral, element is the rare product of bamboo mat spread on the floor for people to sit in ancient China GrandTech, is considered as rare famous and precious tonic in Hongkong and Macro and overseas market.
Application for a patent for invention 201510798413.3, disclose a kind of salamander collagen burn cream and preparation method thereof, each raw material is taken: salamander collagen 5-15g, Giant salamander oil 5 ~ 15ml, Oleum sesami 35 ~ 45ml, Cera Flava 10 ~ 20g, SANHUANG 30 ~ 40g and Borneolum Syntheticum 3 ~ 5g, described SANHUANG is that the Rhizoma Coptidis of 1:1:1, Cortex Phellodendri and Radix Et Rhizoma Rhei form by weight ratio by following proportioning raw materials；SANHUANG and Borneolum Syntheticum are all ground into powder, standby；First by Cera Flava melt, be subsequently adding at Oleum sesami and SANHUANGFEN, 100-105 DEG C mixing boil 15 ~ 20min after, filter, take liquid；After room temperature is down to by temperature of liquid, add Andrias davidianus Blanchard salamander oil and Borneolum Syntheticum powder, at a temperature of being subsequently placed in 4-10 DEG C；When temperature of liquid drops to 4-10 DEG C, add salamander collagen, stirring and evenly mixing, finally add vaseline and be modulated into the ointment of certain stickiness, obtain product.The patented product is applicable to the healing of wound surface burn, though not staying scar, but skin skin quality has an impact, it is impossible to meet Ms's high request to skin skin quality.
Summary of the invention
For above-mentioned technical problem, the invention provides a kind of Andrias davidianus Blanchard skin human body skin and repair unguentum and preparation method thereof.Formula uses Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder and Oleum Brassicae campestris as main component, can quickly repair impaired skin histology and cell.
In order to realize foregoing invention purpose, the present invention adopts the following technical scheme that:
A kind of Andrias davidianus Blanchard skin human body skin repairs unguentum, is made up of the raw material of following weight portion: Andrias davidianus Blanchard preserved egg white lead 30-40 part, Andrias davidianus Blanchard Skin mucus egg albumen powder 15-20 part, Oleum Brassicae campestris 50-60 part, Borneolum Syntheticum 5-10 part, Aloe 5-10 part, Herba Menthae 5-10 part and Mel 5-10 part.
Preferably, it is made up of the raw material of following weight portion: 36 parts of Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder 16 parts, Oleum Brassicae campestris 55 parts, Borneolum Syntheticum 8 parts, Aloe 6 parts, Herba Menthae 5 parts and Mel 5 parts.
Preferably, described Andrias davidianus Blanchard preserved egg white lead and Andrias davidianus Blanchard Skin mucus egg albumen powder are the second filial Andrias davidianus Blanchard of artificial cultivation and are prepared from.
Andrias davidianus Blanchard skin is rich in high protein, low fat, and protein content is 16%～25%, the highest in each position of Andrias davidianus Blanchard.Can quickly repair skin, make skin recover elasticity.Mucus be mainly composed of mucopolysaccharide albumen, fibrous matter, hormone and " Magainin ", the mucopolysaccharide albumen in Andrias davidianus Blanchard skin mucus has good antioxidant activity, repairs impaired skin histology and cell, can effective delay skin aging.
Oleum Brassicae campestris rich in vitamin E and antioxidant content, therefore it can protect skin, especially can prevent skin injury and aging, make skin have gloss；Can play the effect of eliminating toxin and beautifying the skin in Mel containing the aminoacid of needed by human body, vitamin, fructose, Borneolum Syntheticum, Aloe and Herba Menthae are all
There is inflammation of releiving, make skin skin keep the effect of moisture.
Andrias davidianus Blanchard skin human body skin of the present invention repairs the preparation method of unguentum, comprises the steps:
1) gather Andrias davidianus Blanchard Skin mucus, add sodium hydroxide solution, at 40-50 DEG C, stir 1-2h；Feed liquid is centrifuged, supernatant adds dehydrated alcohol, adjusts pH to 7-8, at 1-5 DEG C, stand 5-10h；Centrifugal segregation supernatant, by precipitation absolute ethanol washing 1-3 time, vacuum drying, obtains Andrias davidianus Blanchard Skin mucus egg albumen powder, standby；
The present invention uses alkaline extraction glycoprotein, and its yield and antioxidant activity are best, and investigate each step of Andrias davidianus Blanchard mucous glycoprotein alkaline extraction technique, obtain the optimised process that Andrias davidianus Blanchard mucous glycoprotein is extracted.
2) take fresh Andrias davidianus Blanchard skin, clean, blend, add the isopropanol of quality of material 2 times, defat at 70-80 DEG C, is then centrifuged for, the isopropanol of the quality such as addition in precipitation, defat 1-2h at 70-80 DEG C, add water in the material after defat homogenate, and tune pH value is 7-8, adding hydrolytic enzyme, after hydrolyzing 5-8h at 40-60 DEG C, enzyme denaturing sterilizes, centrifugal, take supernatant lyophilization, obtain Andrias davidianus Blanchard preserved egg white lead, standby；
3) Borneolum Syntheticum of formula ratio, Aloe and Herba Menthae are smashed, add the Oleum Brassicae campestris of formula ratio, Mel and step 1) and 2) egg albumen powder that obtains, stirring and evenly mixing, obtain Andrias davidianus Blanchard skin human body skin and repair unguentum.
Preferably, described step 1) adds quality is quality of material 25 times of sodium hydroxide solution, and concentration of sodium hydroxide solution is 0.4mol/L.When solid-liquid ratio is 1:25, when alkali concn reaches 0.4mol/L, Andrias davidianus Blanchard mucous glycoprotein extraction rate reached is to the highest, and extraction ratio is 10.25%.
Preferably, described hydrolytic enzyme is the compound enzyme that alkaline protease and papain mix with the mass ratio of 1:3, and the hydrolysis effect of this compound enzyme is best.
It is further preferred that the enzyme dosage of described hydrolytic enzyme is 2000U/g, the degree of hydrolysis under this consumption is best.
Preferably, described step 2) amount of water is quality of material 4 times, the degree of hydrolysis of this solid-liquid ratio is best.
The beneficial effects of the present invention is:
1, the Andrias davidianus Blanchard skin human body skin of the present invention repairs unguentum with Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder and Oleum Brassicae campestris as main component, coordinate Borneolum Syntheticum, Aloe, Herba Menthae and Mel, impaired skin there is good repair, as to burn, scalded skin reparation effect good, it is particularly well-suited to the reparation of cicatrical skin, such as the cicatrix after removal pox print and wound healing.
2, the preparation method of Andrias davidianus Blanchard entirety egg albumen powder of the present invention, first uses alkali to carry Andrias davidianus Blanchard Skin mucus glycoprotein, carries out alkali and carry process optimization, ensure extraction ratio and the anti-oxidation function of glycoprotein, enzyme carries Andrias davidianus Blanchard preserved egg white lead again, optimizes enzyme and puies forward technique, and extraction ratio is up to 42.5%.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the essentiality content of the present invention is described in further detail.
Embodiment 1
A kind of Andrias davidianus Blanchard skin human body skin repairs unguentum, is made up of the raw material of following weight portion: 30 parts of Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder 15 parts, Oleum Brassicae campestris 50 parts, Borneolum Syntheticum 5 parts, Aloe 5 parts, Herba Menthae 5 parts and Mel 5 parts.
Described Andrias davidianus Blanchard preserved egg white lead and Andrias davidianus Blanchard Skin mucus egg albumen powder are the second filial Andrias davidianus Blanchard of artificial cultivation and are prepared from.
Embodiment 2
A kind of Andrias davidianus Blanchard skin human body skin repairs unguentum, is made up of the raw material of following weight portion: 40 parts of Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder 20 parts, Oleum Brassicae campestris 60 parts, Borneolum Syntheticum 10 parts, Aloe 10 parts, Herba Menthae 10 parts and Mel 10 parts.
Described Andrias davidianus Blanchard preserved egg white lead and Andrias davidianus Blanchard Skin mucus egg albumen powder are the second filial Andrias davidianus Blanchard of artificial cultivation and are prepared from.
Embodiment 3
A kind of Andrias davidianus Blanchard skin human body skin repairs unguentum, is made up of the raw material of following weight portion: 32 parts of Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder 16 parts, Oleum Brassicae campestris 55 parts, Borneolum Syntheticum 8 parts, Aloe 5 parts, Herba Menthae 6 parts and Mel 8 parts.
Described Andrias davidianus Blanchard preserved egg white lead and Andrias davidianus Blanchard Skin mucus egg albumen powder are the second filial Andrias davidianus Blanchard of artificial cultivation and are prepared from.
Embodiment 4
A kind of Andrias davidianus Blanchard skin human body skin repairs unguentum, is made up of the raw material of following weight portion: 36 parts of Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder 18 parts, Oleum Brassicae campestris 52 parts, Borneolum Syntheticum 6 parts, Aloe 6 parts, Herba Menthae 7 parts and Mel 6 parts.
Described Andrias davidianus Blanchard preserved egg white lead and Andrias davidianus Blanchard Skin mucus egg albumen powder are the second filial Andrias davidianus Blanchard of artificial cultivation and are prepared from.
Embodiment 5
A kind of Andrias davidianus Blanchard skin human body skin repairs unguentum, is made up of the raw material of following weight portion: 36 parts of Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder 16 parts, Oleum Brassicae campestris 55 parts, Borneolum Syntheticum 8 parts, Aloe 6 parts, Herba Menthae 5 parts and Mel 5 parts.
Described Andrias davidianus Blanchard preserved egg white lead and Andrias davidianus Blanchard Skin mucus egg albumen powder are the second filial Andrias davidianus Blanchard of artificial cultivation and are prepared from.
Embodiment 6
The present embodiment is the preparation method of enforcement 3, comprises the steps:
1) gather Andrias davidianus Blanchard Skin mucus, add sodium hydroxide solution, at 40 DEG C, stir 2h；Feed liquid is centrifuged, supernatant adds dehydrated alcohol, adjusts pH to 7, at 1 DEG C, stand 5h；Centrifugal segregation supernatant, by precipitation absolute ethanol washing 1 time, vacuum drying, obtains Andrias davidianus Blanchard Skin mucus egg albumen powder, standby；
2) take fresh Andrias davidianus Blanchard skin, clean, blend, add the isopropanol of quality of material 2 times, defat at 70 DEG C, is then centrifuged for, the isopropanol of the quality such as addition in precipitation, defat 2h at 70 DEG C, add water in the material after defat homogenate, and adjusting pH value is 7, adding hydrolytic enzyme, after hydrolyzing 8h at 40 DEG C, enzyme denaturing sterilizes, centrifugal, take supernatant lyophilization, obtain Andrias davidianus Blanchard preserved egg white lead, standby；
3) Borneolum Syntheticum of formula ratio, Aloe and Herba Menthae are smashed, add the Oleum Brassicae campestris of formula ratio, Mel and step 1) and 2) egg albumen powder that obtains, stirring and evenly mixing, obtain Andrias davidianus Blanchard skin human body skin and repair unguentum.
Embodiment 7
The present embodiment is the preparation method of enforcement 4, comprises the steps:
1) gather Andrias davidianus Blanchard Skin mucus, add sodium hydroxide solution, at 50 DEG C, stir 1.5h；Feed liquid is centrifuged, supernatant adds dehydrated alcohol, adjusts pH to 8, at 5 DEG C, stand 5h；Centrifugal segregation supernatant, by precipitation absolute ethanol washing 1-3 time, vacuum drying, obtains Andrias davidianus Blanchard Skin mucus egg albumen powder, standby；
2) take fresh Andrias davidianus Blanchard skin, clean, blend, add the isopropanol of quality of material 2 times, defat at 80 DEG C, is then centrifuged for, the isopropanol of the quality such as addition in precipitation, defat 1h at 80 DEG C, add water in the material after defat homogenate, and adjusting pH value is 8, adding hydrolytic enzyme, after hydrolyzing 5h at 60 DEG C, enzyme denaturing sterilizes, centrifugal, take supernatant lyophilization, obtain Andrias davidianus Blanchard preserved egg white lead, standby；
3) Borneolum Syntheticum of formula ratio, Aloe and Herba Menthae are smashed, add the Oleum Brassicae campestris of formula ratio, Mel and step 1) and 2) egg albumen powder that obtains, stirring and evenly mixing, obtain Andrias davidianus Blanchard skin human body skin and repair unguentum.
Embodiment 8
The present embodiment is the preparation method of enforcement 5, comprises the steps:
1) gather Andrias davidianus Blanchard Skin mucus, add sodium hydroxide solution, at 42 DEG C, stir 1.5h；Feed liquid is centrifuged, supernatant adds dehydrated alcohol, adjusts pH to 7.6, at 2 DEG C, stand 6h；Centrifugal segregation supernatant, by precipitation absolute ethanol washing 2 times, vacuum drying, obtains Andrias davidianus Blanchard Skin mucus egg albumen powder, standby；
2) take fresh Andrias davidianus Blanchard skin, clean, blend, add the isopropanol of quality of material 2 times, defat at 72 DEG C, is then centrifuged for, the isopropanol of the quality such as addition in precipitation, defat 1.6h at 73 DEG C, add water in the material after defat homogenate, and adjusting pH value is 7.8, adding hydrolytic enzyme, after hydrolyzing 6h at 45 DEG C, enzyme denaturing sterilizes, centrifugal, take supernatant lyophilization, obtain Andrias davidianus Blanchard preserved egg white lead, standby；
3) Borneolum Syntheticum of formula ratio, Aloe and Herba Menthae are smashed, add the Oleum Brassicae campestris of formula ratio, Mel and step 1) and 2) egg albumen powder that obtains, stirring and evenly mixing, obtain Andrias davidianus Blanchard skin human body skin and repair unguentum.
Claims (8)
1. an Andrias davidianus Blanchard skin human body skin repairs unguentum, it is characterised in that: it is made up of the raw material of following weight portion: Andrias davidianus Blanchard preserved egg white lead 30-40 part, Andrias davidianus Blanchard Skin mucus egg albumen powder 15-20 part, Oleum Brassicae campestris 50-60 part, Borneolum Syntheticum 5-10 part, Aloe 5-10 part, Herba Menthae 5-10 part and Mel 5-10 part.
A kind of Andrias davidianus Blanchard skin human body skin the most according to claim 1 repairs unguentum, it is characterised in that: it is made up of the raw material of following weight portion: 36 parts of Andrias davidianus Blanchard preserved egg white lead, Andrias davidianus Blanchard Skin mucus egg albumen powder 16 parts, Oleum Brassicae campestris 55 parts, Borneolum Syntheticum 8 parts, Aloe 6 parts, Herba Menthae 5 parts and Mel 5 parts.
3. repair unguentum according to a kind of Andrias davidianus Blanchard skin human body skin described in claims 1 or 2, it is characterised in that: described Andrias davidianus Blanchard preserved egg white lead and Andrias davidianus Blanchard Skin mucus egg albumen powder are the second filial Andrias davidianus Blanchard of artificial cultivation and are prepared from.
A kind of Andrias davidianus Blanchard skin human body skin the most according to claim 1 repairs the preparation method of unguentum, it is characterised in that: comprise the steps:
1) gather Andrias davidianus Blanchard Skin mucus, add sodium hydroxide solution, at 40-50 DEG C, stir 1-2h；Feed liquid is centrifuged, supernatant adds dehydrated alcohol, adjusts pH to 7-8, at 1-5 DEG C, stand 5-10h；Centrifugal segregation supernatant, by precipitation absolute ethanol washing 1-3 time, vacuum drying, obtains Andrias davidianus Blanchard Skin mucus egg albumen powder, standby；
2) take fresh Andrias davidianus Blanchard skin, clean, blend, add the isopropanol of quality of material 2 times, defat at 70-80 DEG C, is then centrifuged for, the isopropanol of the quality such as addition in precipitation, defat 1-2h at 70-80 DEG C, add water in the material after defat homogenate, and tune pH value is 7-8, adding hydrolytic enzyme, after hydrolyzing 5-8h at 40-60 DEG C, enzyme denaturing sterilizes, centrifugal, take supernatant lyophilization, obtain Andrias davidianus Blanchard preserved egg white lead, standby；
3) Borneolum Syntheticum of formula ratio, Aloe and Herba Menthae are smashed, add the Oleum Brassicae campestris of formula ratio, Mel and step 1) and 2) egg albumen powder that obtains, stirring and evenly mixing, obtain Andrias davidianus Blanchard skin human body skin and repair unguentum.
A kind of Andrias davidianus Blanchard skin human body skin the most according to claim 4 repairs the preparation method of unguentum, it is characterised in that: described step 1) adds quality is quality of material 25 times of sodium hydroxide solution, and concentration of sodium hydroxide solution is 0.4mol/L.
A kind of Andrias davidianus Blanchard skin human body skin the most according to claim 4 repairs the preparation method of unguentum, it is characterised in that: described hydrolytic enzyme is the compound enzyme that alkaline protease and papain mix with the mass ratio of 1:3.
A kind of Andrias davidianus Blanchard skin human body skin the most according to claim 6 repairs the preparation method of unguentum, it is characterised in that: the enzyme dosage of described hydrolytic enzyme is 2000U/g.
A kind of Andrias davidianus Blanchard skin human body skin the most according to claim 4 repair unguentum preparation method, it is characterised in that: described step 2) amount of water is quality of material 4 times.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491914A (en) * | 2016-12-05 | 2017-03-15 | 郑州诚合信息技术有限公司 | A kind of Western medicine compound for treating scald |
| CN108066369A (en) * | 2016-11-16 | 2018-05-25 | 太鲵生物科技（天津）有限公司 | A kind of preparation method of giant salamander pituitary extract |
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