CN1251738C - Chinese medicine for treating ashen nail and its preparation method - Google Patents

Chinese medicine for treating ashen nail and its preparation method Download PDF

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CN1251738C
CN1251738C CN 03149754 CN03149754A CN1251738C CN 1251738 C CN1251738 C CN 1251738C CN 03149754 CN03149754 CN 03149754 CN 03149754 A CN03149754 A CN 03149754A CN 1251738 C CN1251738 C CN 1251738C
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onychomycosis
ampelopsis
chinese medicine
treatment
method
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CN1513530A (en
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王春荣
周志杰
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王春荣
周志杰
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Abstract

本发明公开了一种治疗灰指甲的中药及其制备方法,所述中药为:知母、白蔹、桔梗组分;可将知母、白蔹、桔梗按比例混合,研磨,浸泡于冰醋酸内,浸泡温度10-30℃,浸泡密封20-40天,过滤,即得。 The present invention discloses a traditional Chinese medicine and its preparation method for the treatment of onychomycosis, the medicine is: anemarrhenae, Ampelopsis, Campanulaceae component; may be Zhimu, Ampelopsis, bellflower proportionally mixing, milling, immersed in glacial acetic acid the soaking temperature of 10-30 deg.] C, soaked seals 20-40 days, filtered to obtain. 本发明具有疗程短,见效快,使用方便,彻底根治,不易复发的优点。 The present invention has a short course, quick, easy to use, complete cure, the advantages of easy to relapse.

Description

一种治疗灰指甲的中药及其制备方法 For the treatment of onychomycosis of traditional Chinese medicine and its preparation method

技术领域 FIELD

本发明涉及一种治疗皮肤病的药物,尤其涉及一种治疗灰指甲(手足癣)的中药及其制备方法。 The present invention relates to a drug for the treatment of dermatoses, in particular, it relates to a traditional Chinese medicine onychomycosis (tinea) and preparation methods of treating.

背景技术 Background technique

灰指甲(手足癣)是常见的皮肤病,传染速度快,其多为皮肤真菌和皮肤细菌合并感染引起。 Onychomycosis (tinea) is a common skin disease, high infection rate, which is more than skin fungal and bacterial skin infection caused. 该病发病率目前还有逐年上升的趋势。 Incidence of the disease there are still an increasing trend. 治疗灰指甲(手足癣)主要以药物为主,治疗的方法虽多,但大多只能达到近期临床效果,易复发难以根治。 Treatment of onychomycosis (tinea) mainly based drugs, treatment methods are numerous, but most can only achieve short-term clinical effects, easy to relapse difficult to cure. 西药多采用皮质激素或细胞免疫抑制剂,如乙双吗啉、白血宁等,这类药物虽有较好的近期疗效,但这类药物在抑制DNA合成的同时,由于对白细胞杀伤过多,故已经提醒禁用或慎用,它们存在的最大缺点是长期使用能使皮肤的表皮和真皮变薄,并能引起毛细血管扩张及成瘾性等严重毒副反应,并发症多,适应范围小,且价格也比较昂贵;而激素的最大副作用则是虽能获得一时之效,但一停药其机体的内分泌系统易出现发生“反跳”现象,使本病越陷越深。 Western use more corticosteroids or cellular immune inhibitors, such as Yishuangmalin, white blood Ning, these drugs despite a good curative effect, but these drugs while inhibition of DNA synthesis, since anti excessive leukocytes, it has reminded disabled or used with caution, the biggest drawback of their existence is the long-term use can make the skin epidermis and dermis thinning, and can cause severe toxicity telangiectasia and addiction and other complications, a small adaptation, and the price is also more expensive; but the biggest side effects of hormones are though to get temporary effect, but a withdrawal in which the body's endocrine system prone to happen "rebound" phenomenon, so that the disease deeper and deeper.

国内治疗手足癣皮肤病的外用药名目繁多,如“皮炎平”、“皮康霜”、“皮康王”、“达克宁”等等。 Domestic treatment of tinea of ​​skin diseases for external use various names, such as "Pi Yan Ping", "Pi cream", "Wang Pi," "Miconazole" and so on. 但因为很多皮肤病都是因真菌感染后合并细菌感染或者皮肤细菌感染后合并真菌感染,而以上所列的多种药膏均不能同时杀灭或者抑制真菌或细菌。 But because many skin diseases are caused by fungal infection with bacterial infection or a bacterial infection of skin fungal infections, and a variety of creams listed above are not simultaneously kill or inhibit fungi or bacteria. 例如,“皮康王”是一种治疗皮肤病的合成膏药,其有效成份为酮康唑和信他素,它对由真菌感染引起的癣症效果尚可,但对由细菌引起的,或者由真菌和细菌合并感染引起的皮肤病如“水泡性香港脚”,效果欠佳;又例如,“达克宁”是一种咪康唑制成的乳膏,其抗真菌效果非常突出,但对因过敏或者混合感染的皮肤病无效。 For example, "Wang Pi" is a synthetic plaster treatment of skin diseases, its active ingredient is ketoconazole and believe in him prime, ringworm effect it can still be caused by a fungal infection, but caused by bacteria or by fungi and bacterial merger skin diseases such as "vesicular athlete's foot" caused by infection, ineffective; another example, "miconazole" is the cream one kind of miconazole made its antifungal effect is very prominent, but due to allergies or mixed infection of skin disease is not valid.

发明内容 SUMMARY

本发明的目的是提供一种治疗皮肤病的药物,尤其提供一种治疗灰指甲(手足癣)的中药及其制备方法,克服了目前西药治疗毒副反应严重,中药治疗存在疗效不确切的缺点。 Object of the present invention is to provide a drug for the treatment of dermatoses, in particular, provides a traditional Chinese medicine treatment of onychomycosis (tinea) methods for their preparation, to overcome the current serious western medicine toxicity, the presence of imprecise efficacy disadvantages traditional Chinese medicine .

本发明的目的是通过以下技术方案来实现的:一种治疗灰指甲的中药,包括以下组分:知母、白蔹、桔梗;所述组分可为以下重量份组分:知母30-70、白蔹30-70、桔梗30-70;优选为:知母40-60、白蔹40-60、桔梗40-60;最好为知母50、白蔹50、桔梗50;所述治疗灰指甲的中药可制成任何一种药剂学上所说的皮肤外用剂型,尤其为油剂、乳剂、霜剂、浸涂剂、膏剂、喷雾剂、酊剂、合剂、水剂、胥剂。 Object of the present invention is achieved by the following technical solution to achieve: a method of treating onychomycosis medicine, comprising the following components: altogether, Ampelopsis, bellflower; the components can be parts or less by weight of the components: altogether 30- 70, Ampelopsis 30-70, 30-70 Campanulaceae; preferably: 40-60 altogether, Ampelopsis 40-60, 40-60 Campanulaceae; Zhimu preferably 50, Ampelopsis 50, balloon 50; the treatment onychomycosis medicine may be made of any of said upper one kind of pharmaceutically skin external formulations, in particular oils, emulsions, creams, dip coating, ointments, sprays, tinctures, agent, agent, Xu agent.

一种治疗灰指甲的中药的制备方法,包括以下步骤:将知母、白蔹、桔梗按上述比例混合,研磨,浸泡于冰醋酸内,浸泡温度10-30℃,浸泡密封20-40天,过滤,即得;所述过滤为0.01μm-2μm;所述浸泡温度优选15-25℃,最好20℃;所述浸泡密封优选25-35天,最好30天;所述冰醋酸浓度为20-40%,优选为25-35%,最好30%。 A method of preparing Chinese medicine treatment of onychomycosis, comprising the steps of: altogether, Ampelopsis, bellflower mixing the above proportions, grinding, immersed in glacial acetic acid, a temperature of 10-30 deg.] C soak, soak for 20-40 days seal, filtering, to obtain; the filter is a 0.01μm-2μm; the soaking temperature is preferably 15-25 deg.] C, preferably 20 ℃; soaking said seal preferably 25 to 35 days, preferably 30 days; the concentration of acetic acid 20-40%, preferably 25-35%, preferably 30%.

所述方法还包括按皮肤常规外用药剂制剂法制成各种剂型,灌装,灭菌。 The method further comprises pressing the skin a conventional external agent formulation SYSTEM into various dosage forms, filling, sterilization.

本发明原料知母:性味苦寒,能清热泻火、滋阴润躁,体外试用,对真菌及白念珠菌有抑制作用;白蔹:性味苦微寒,能清热解毒,体外试用,对红色表皮癣菌有抑制作用;桔梗:性味苦寒,能清热解毒,体外试用,对絮状表皮癣菌有抑制作用。 Material altogether present invention: taste bitter cold, heat purging fire, Yin mania, reserve vitro trial inhibit fungal and Candida albicans; Ampelopsis: of bitter slightly cold, can detoxify vitro trial to mentagrophytes inhibition red skin; Campanulaceae: taste bitter cold, can detoxify vitro trial inhibited Epidermophyton floccosum.

本发明治疗手足癣的中药具有渗透力极强,能在较短的时间内快速有效的杀灭浅表皮与深处的真菌和细菌的功能,主治手足癣。 Chinese medicine treatment tinea of ​​the present invention having a strong penetration can quickly and effectively kill fungi and bacteria Functions of the epidermis and deep within a short period of time, treating tinea.

本发明具有以下优点:1、与目前同类药物相比,具有疗程短,见效快,使用方便,彻底根治,不易复发的优点。 The present invention has the following advantages: 1, compared with the current similar drugs with a short course, quick, easy to use, complete cure, the advantages of easy to relapse.

2、本发明所述治疗手足癣的中药经过多年临床反复论证,证明本发明药物疗效可靠,无毒,无副作用,可根治该病。 2, medicine of the present invention is the treatment of tinea after years of repeated clinical demonstration proved that the drug efficacy of the present invention, a reliable, non-toxic, no side effects, can cure the disease.

3、本发明所述治疗手足癣的中药经过多年临床反复论证,证明具有显著的渗透力,能够直接快速彻底杀灭皮肤表浅及深处的真菌和细菌,可在较短的时间内,达到治愈效果。 3, the medicine of the present invention is the treatment of tinea after years of repeated clinical demonstration, proved to have a significant penetration, can be directly and quickly completely kill the skin superficial and deep fungi and bacteria, may in a short time to achieve healing effect.

为证明本发明所述上述效果,进行了以下动物实验和临床试验:一、以下实验可以说明本发明药物组合物的协同作用和增效作用1.体外实验——本发明药物组合物及其组分体外对几种常见致病真菌和部分细菌(代表菌)的抗菌作用比较,通过测定其最小抑菌浓度(MIC),证明本发明的对真菌的抑菌作用、及对真菌和细菌的杀灭作用。 To demonstrate the present invention, the above effects, the following animal experiments and clinical trials: one, the following experiments can be described synergistic pharmaceutical compositions of the present invention and the synergistic effect 1. In vitro test - the present invention is a pharmaceutical composition and group antibacterial effect vitro of several pathogenic fungi and some bacteria (representing bacteria) comparing, by determining the minimum inhibitory concentration (the MIC), demonstrated inhibitory effect against fungi of the present invention, and killing of fungi and bacteria off effect.

1.1材料与方法1.1.1菌种真菌、细菌引自辽宁省锦州市古塔区中西医院皮肤科。 1.1 Materials and Methods 1.1.1 species of fungi, bacteria cited Western Hospital dermatologist Guta District of Jinzhou City, Liaoning Province.

1.1.2培养基真菌培养基为沙氏肉汤培养基,由主要由1%蛋白胨和2%葡萄糖组成,PH为6-6.5;细菌培养基为普通肉汤,PH为7。 1.1.2 Medium fungal culture of Sabouraud broth, a mainly consisting of 1% peptone and 2% glucose, PH 6-6.5; bacterial medium was nutrient broth, PH 7.

1.1.3药液培养基的制备按所述本发明组合物不同的比例配制。 Preparation 1.1.3 liquid medium in different inventive compositions the ratio of the present formulation. 各组合物配方先用1ml 95%L醇溶解,再加无菌蒸馏水至5ml;然后各吸取上述配液0.2ml,分别加到1.8ml的培养基中,摇匀后对倍稀释出不同浓度的药液培养基。 Each composition formula first with 1ml 95% L alcohol was dissolved, together with sterile distilled water to 5ml; and each of the drawing above the dosing 0.2ml, were added to the medium 1.8ml of, after shaking diluted with different concentrations of times liquid culture medium. 实验时,每管药液培养基1ml中加入菌液0.02ml;1ml含皮癣菌105-106个或酵母样真菌103-104个。 Experiment, each tube liquid medium 1ml was added bacteria 0.02ml; 1ml containing dermatophyte 105-106 or yeast-like fungi 103-104 a. 摇匀后放于28℃温箱内培养120-168小时,其中酵母样真菌48小时,观察结果。 Shake placed in 28 ℃ temperature inside cultured 120-168 hours, wherein the yeast-like fungi 48 hours observation.

1.1.4药效判断标准肉汤清亮同于药物空白对照管,为有抑杀菌作用;肉汤明显浑浊,或有菌膜生长,则为无抑杀菌作用。 1.1.4 Efficacy criteria meat Tangqing Liang same pharmaceutical blank tube, that there is suppression sterilization; broth obvious turbidity, or plaque growth, was no suppression sterilization.

1.1.5杀菌浓度的测定本方法应用琼脂倾注法。 1.1.5 bactericidal concentration assay the method agar pour method. 先将本发明药物组合物配成含不同浓度药液培养基,0.01μg/ml-100μg/ml;再每ml分别加入测试菌,菌量为103-106个(ml),作用5分钟,分别取样0.1ml接种子平皿,倒入沙氏琼脂,充分摇匀,培养5-10天;活菌计数和统计结果。 First the pharmaceutical compositions of the invention formulated with different concentrations of liquid medium, 0.01μg / ml-100μg / ml; then per ml were added to the test bacteria, bacteria in an amount of 103-106 a (ml), the role for 5 minutes, respectively, sampling 0.1ml then seed plates, poured into Sabouraud agar, shake well, cultured for 5-10 days; viable count and statistics.

1.2实验结果1.2.1组合物及其组分体外对常见致病真菌(代表菌)的作用组合物与其组分知母、白蔹、桔梗对常见致病真菌(代表菌)抑菌试验比较表明,组合物在3~7∶3~7重量份配比比例组合物对几种常见致病真菌的最小抑菌浓度(MIC)较低,作用较强(见表1),证明组合物优于其单组分药物,抗真菌有协同作用。 1.2 Experimental results 1.2.1 composition and its components in vitro against pathogenic fungi (on behalf of bacteria) role in the composition of its components altogether, white Lian, CNS of pathogenic fungi (on behalf of bacteria) antibacterial test comparison shows the composition (MIC) lower in parts 3 ~ 7:3 to 7 weight proportion ratio of the composition of the minimum inhibitory concentration of several pathogenic fungi, is stronger (see Table 1), demonstrating that the composition superior mono-component drugs, antifungal synergistic effect.

1.2.2组合物及其组分体外对常见致病细菌(代表菌)的作用组合物与其组分知母、白蔹、桔梗对常见致病细菌(代表菌)抑菌试验比较表明,组合物在3~7∶3~7重量份配比时对几种常见致病真菌的最小抑菌浓度(MIC)也较低,作用较强(见表2),证明组合物优于其单组分药物,抗真菌有协同作用。 1.2.2 composition and its components in vitro effects on pathogenic bacteria (representing bacteria) composition and its components altogether, Ampelopsis, CNS of pathogenic bacteria (representing bacteria) antibacterial test comparison shows that the composition also lower at 3 ~ 7:3 to 7 parts by weight ratio of several pathogenic fungi minimum inhibitory concentration (the MIC), is stronger (see Table 2), demonstrating that the composition superior to single-component drugs, anti-fungal synergistic effect.

1.2.3组合物及其组分对5分钟内常见致病细菌和真菌(代表菌)的杀菌作用测定组合物及其组分知母、白蔹、桔梗对3株常见致病细菌和真菌的杀菌作用,结果表明,组合物在3~7∶3~7重量份配比具有较好的杀菌作用(见表3),对致病细菌代表菌,组合物效果不低于其组分,仍有较好的杀灭细菌作用;对真菌代表菌,组合物优于其组分,杀灭真菌有协同作用。 1.2.3 compositions and composition components was measured within 5 minutes of pathogenic bacteria and sterilization fungi (representing bacteria) for its components altogether, Ampelopsis, CNS of three pathogenic bacteria and fungi sterilization results show that the composition has a better fungicidal action (see Table 3) in parts 3 ~ 7:3 to 7 wt ratio of pathogenic bacteria representative of bacteria, the composition effect is less than its components, still better kill bacterial action; fungi representative of bacteria, the composition is superior to its components, fungicidal synergistic effect.

表1本发明组合物不同浓度体外对三种常见致病真菌(代表菌)的抑菌作用 Table inhibitory effect of different concentration for a composition of the invention three common pathogenic fungi (representative of microorganisms)

注:1.表癣菌培养140小时,白色念珠菌培养48小时观察结果。 NOTE: TABLE 1 140 hours culture rubrum, Candida albicans cultured for 48 hours observation.

表2本发明组合物不同浓度体外对三种常见致病细菌(代表菌)的抑菌作用 Table vitro inhibitory effect of different concentrations of compositions of the invention two three common pathogenic bacteria (the representative microorganisms)

注:1.表癣菌培养140小时,白色念珠菌培养48小时观察结果。 Notes: 1. Table rubrum culture 140 hours, C. albicans cultured for 48 hours observation.

表3组合物对三种常见致病细菌和真菌5分钟的杀菌率 Table 3 The composition of three common pathogenic bacteria and fungi 5 minutes sterilization rate

注:1.实验时各种比例的组合物总量均为100μg/ml。 Note: 1 experiment the total composition of various proportions were 100μg / ml.

所述实验表明,本发明组合物对对常见致病细菌如红色表皮癣菌、紫色表皮癣菌、金黄色葡萄球菌和真菌如白色念珠菌具有显著的杀菌作用。 The experiments show that pathogenic bacteria such as red Epidermophyton, purple Epidermophyton, Staphylococcus aureus and fungi such as Candida albicans has a significant bactericidal effect compositions of the present invention is right.

发明人对220例病例用本发明组合物中药进行了治疗观察,疗效结果为治愈率90%以上;有效率90%以上;无效:1%以下。 The inventors in 220 cases for the composition of the present invention, TCM treatment observed efficacy results than the cure rate of 90%; more than 90% efficiency; invalid: 1% or less. 一般轻度感染者使用3-5天可愈。 Generally mild infection 3-5 days more. 重度感染者5-10天可愈。 Severe infection 5-10 days more.

本发明组合物中药使用方法:每天晚上洗完手脚后,用棉签蘸药液,反复在患处,敷擦5分钟左右自然凉干。 The composition of the present invention is medicine use: every night washing hands with a cotton swab dipped in liquid, again in the affected area, apply rub about 5 minutes the natural dry. 注意在使用本发明药物治疗手足癣药,如果手足癣患处有皮肤发炎,溃烂等现象,有微刺痛感,您的手癣和脚癣同时存在,可同时治疗,以达到彻底杀灭真菌和细菌的目的,避免交叉感染而复发,在治疗过程中,患处可避免接触碱性较重的物品,如洗衣粉、洗涤剂、水泥、碱等。 Note the use of the drug present invention treating tinea medication if tinea affected area of ​​skin inflammation, ulcers and other phenomena, micro-tingling, your hand ringworm and athlete's foot exist, can be treated at the same time, in order to achieve complete kill fungi and bacteria purpose, to avoid cross-infection and relapse, during treatment, the affected area can be avoided contact with alkaline heavy items, such as detergent, detergent, cement, alkali or the like.

具体实施方式 Detailed ways

实施例1溶液剂按以下配比称取各组分(kg):知母50、白蔹50、桔梗50;制备方法,包括以下步骤:将知母、白蔹、桔梗按上述比例混合,研磨,浸泡30%于冰醋酸内,浸泡温度20℃,浸泡密封30天,过滤0.01μm,灌装,蒸汽灭菌,即得。 A solution Example said following compounding ratio of the components (kg): altogether 50, Ampelopsis 50, balloon 50; preparation method, comprising the steps of: altogether, Ampelopsis, bellflower mixing the above proportions, grinding immersion in 30% acetic acid, soaking temperature 20 ℃, immersion seal 30 days, 0.01 m filtered, filled, steam sterilization, i.e., too.

实施例2溶液喷雾剂按以下配比称取各组分(kg):知母30、白蔹30、桔梗30;制备方法,包括以下步骤:将知母、白蔹、桔梗按上述比例混合,研磨,浸泡20%于冰醋酸内,浸泡温度15℃,浸泡密封25天,过滤2μm,灌装喷雾瓶,蒸汽灭菌,即得。 2 was spray EXAMPLE said following compounding ratio of the components (kg): altogether 30, Ampelopsis 30, balloon 30; preparation method, comprising the steps of: altogether, Ampelopsis, bellflower mixing the above proportions, grinding, soaking of 20% in acetic acid, soaking temperature 15 ℃, soaking seal 25 days, filtered and 2 m, the filling spray bottles, steam sterilization, i.e., too.

实施例3膏剂按以下配比称取各组分(kg):知母70、白蔹70、桔梗70;制备方法,包括以下步骤:将知母、白蔹、桔梗按上述比例混合,研磨,浸泡40%于冰醋酸内,浸泡温度25℃,浸泡密封35天,过滤0.5μm,加入赋形剂十八醇5kg、硬脂酸9kg、单硬脂酸甘油脂4kg、凡士林3kg、甘油9kg,三乙醇胺0.1kg和余量蒸馏水配制成膏剂,灌装,10克/支,100℃蒸汽灭菌15分钟即得。 Example 3 ointment embodiment said following compounding ratio of the components (kg): altogether 70, Ampelopsis 70, balloon 70; preparation method, comprising the steps of: altogether, Ampelopsis, bellflower above proportions, grinding, soaking of 40% in acetic acid, soaking temperature 25 ℃, soaking seal 35 days, filter of 0.5 m, an excipient octadecanol 5kg, stearic 9kg, glyceryl monostearate 4kg, petrolatum 3kg, glycerol 9kg, triethanolamine 0.1kg and the balance distilled water into a paste, filling, 10 grams / branched, 100 ℃ steam sterilization 15 minutes too.

实施例4油剂按以下配比称取各组分(kg):知母40、白蔹40、桔梗40;制备方法,包括以下步骤:将知母、白蔹、桔梗按上述比例混合,研磨,浸泡35%于冰醋酸内,浸泡温度22℃,浸泡密封26天,过滤1μm,加入甘油6kg,加蒸馏水制成100L,摇匀,灌装125ml/瓶,100℃蒸汽灭菌20分钟即得。 Example 4 oil known from the following ingredients taken of the components (kg): altogether 40, Ampelopsis 40, balloon 40; preparation method, comprising the steps of: altogether, Ampelopsis, bellflower mixing the above proportions, grinding , soaked 35% in acetic acid, steeping temperature 22 ℃, soaking seal 26 days, filtered and 1 m, glycerin 6kg, distilled water is made of 100L, shake, filling 125ml / bottle, 100 ℃ steam sterilized for 20 minutes to give .

实施例5酊剂按以下配比称取各组分(kg):知母60、白蔹60、桔梗60;制备方法,包括以下步骤:将知母、白蔹、桔梗按上述比例混合,研磨,浸泡35%于冰醋酸内,浸泡温度22℃,浸泡密封26天,过滤1μm,加30L乙醇,10L丙二醇,8L甘油和余量蒸馏水配制而成酊剂100L。 Example 5 tincture embodiment known according to the following compounding ratio of the components (kg): altogether 60, Ampelopsis 60, balloon 60; preparation method, comprising the steps of: altogether, Ampelopsis, bellflower above proportions, grinding, soaked in 35% in acetic acid, steeping temperature 22 ℃, soaking seal 26 days, filtered and 1 m, adding 30L of ethanol, 10L propylene glycol, 8L glycerin, and the balance distilled water from tincture 100L.

Claims (9)

1.一种治疗灰指甲的中药,由以下重量份的原料药制成:知母30-70、白蔹30-70、桔梗30-70。 1. A method of treating onychomycosis medicine, made of the following parts by weight of the drug: altogether 30-70, Ampelopsis 30-70, bellflower 30-70.
2.根据权利要求1的治疗灰指甲的中药,其特征在于所述原料药的重量份为:知母40-60、白蔹40-60、桔梗40-60。 2. Chinese medicine treatment of onychomycosis according to claim, characterized in that the parts by weight of the drug is: anemarrhenae 40-60, Ampelopsis 40-60, bellflower 40-60.
3.根据权利要求2的治疗灰指甲的中药,其特征在于所述原料药的重量份为:知母50、白蔹50、桔梗50。 3. The medicine treatment of onychomycosis of claim 2, wherein the parts by weight of the drug is: anemarrhenae 50, Ampelopsis 50, balloon 50.
4.根据权利要求1的治疗灰指甲的中药,其特征在于所述中药制剂为油剂、乳剂、霜剂、浸涂剂、膏剂、喷雾剂、酊剂、合剂、水剂或醑剂。 4. The Chinese medicine treatment of onychomycosis of claim 1, wherein said herbal formulation is an oil, emulsions, creams, dip coating, ointments, sprays, tinctures, agent, agent, or elixirs.
5.根据权利要求1~4中任一权利要求所述的一种治疗灰指甲的中药的制备方法,步骤如下:将知母、白蔹、桔梗按权利要求1-3所述的任一比例混合,研磨,浸泡于冰醋酸内,密封浸泡20-40天,过滤,即得。 The preparation method of Chinese medicine of treating onychomycosis 1 to 4, in any one of claims claim, the steps of: altogether, Ampelopsis, bellflower claim any ratio 1-3 mixing, milling, immersed in glacial acetic acid, sealing soak 20-40 days, filtered to obtain.
6.根据权利要求5的治疗灰指甲的中药的制备方法,所述过滤粒径为为0.01μm-2μm。 The production method of Chinese medicine treatment of onychomycosis according to claim 5, wherein the filter particle diameter is 0.01μm-2μm.
7.根据权利要求5的治疗灰指甲的中药的制备方法,所述浸泡温度为10-30℃。 7. A method for preparing medicine treatment of onychomycosis according to claim 5, wherein the soaking temperature is 10-30 ℃.
8.根据权利要求5的治疗灰指甲的中药的制备方法,所述冰醋酸浓度为20-40%。 8. A method for preparing medicine treatment of onychomycosis according to claim 5, wherein the acetic acid concentration of 20-40%.
9.根据权利要求5的治疗灰指甲的中药的制备方法,所述方法还包括按皮肤常规外用药剂制剂法制成各种剂型,灌装,灭菌。 Preparation according to claim medicine treatment of onychomycosis of claim 5, the method further comprises pressing the skin a conventional external agent formulation SYSTEM into various dosage forms, filling, sterilization.
CN 03149754 2003-08-05 2003-08-05 Chinese medicine for treating ashen nail and its preparation method CN1251738C (en)

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Cited By (8)

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US9309436B2 (en) 2007-04-13 2016-04-12 Knauf Insulation, Inc. Composite maillard-resole binders
US9416248B2 (en) 2009-08-07 2016-08-16 Knauf Insulation, Inc. Molasses binder
US9447281B2 (en) 2007-01-25 2016-09-20 Knauf Insulation Sprl Composite wood board
US9464207B2 (en) 2005-07-26 2016-10-11 Knauf Insulation, Inc. Binders and materials made therewith
US9469747B2 (en) 2007-08-03 2016-10-18 Knauf Insulation Sprl Mineral wool insulation
US9492943B2 (en) 2012-08-17 2016-11-15 Knauf Insulation Sprl Wood board and process for its production
US9493603B2 (en) 2010-05-07 2016-11-15 Knauf Insulation Sprl Carbohydrate binders and materials made therewith
US9505883B2 (en) 2010-05-07 2016-11-29 Knauf Insulation Sprl Carbohydrate polyamine binders and materials made therewith

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9464207B2 (en) 2005-07-26 2016-10-11 Knauf Insulation, Inc. Binders and materials made therewith
US9447281B2 (en) 2007-01-25 2016-09-20 Knauf Insulation Sprl Composite wood board
US9309436B2 (en) 2007-04-13 2016-04-12 Knauf Insulation, Inc. Composite maillard-resole binders
US9469747B2 (en) 2007-08-03 2016-10-18 Knauf Insulation Sprl Mineral wool insulation
US9416248B2 (en) 2009-08-07 2016-08-16 Knauf Insulation, Inc. Molasses binder
US9493603B2 (en) 2010-05-07 2016-11-15 Knauf Insulation Sprl Carbohydrate binders and materials made therewith
US9505883B2 (en) 2010-05-07 2016-11-29 Knauf Insulation Sprl Carbohydrate polyamine binders and materials made therewith
US9492943B2 (en) 2012-08-17 2016-11-15 Knauf Insulation Sprl Wood board and process for its production

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