WO2024042374A1 - Sticking plaster for treatment of finger infections such as paronychia - Google Patents
Sticking plaster for treatment of finger infections such as paronychia Download PDFInfo
- Publication number
- WO2024042374A1 WO2024042374A1 PCT/IB2023/053366 IB2023053366W WO2024042374A1 WO 2024042374 A1 WO2024042374 A1 WO 2024042374A1 IB 2023053366 W IB2023053366 W IB 2023053366W WO 2024042374 A1 WO2024042374 A1 WO 2024042374A1
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- WO
- WIPO (PCT)
- Prior art keywords
- paronychia
- gelatin
- plant
- employed
- hydrogel
- Prior art date
Links
- 206010034016 Paronychia Diseases 0.000 title claims abstract description 39
- 241000029132 Paronychia Species 0.000 title claims abstract description 39
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 12
- 239000011505 plaster Substances 0.000 title description 2
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- 239000008273 gelatin Substances 0.000 claims abstract description 17
- 229920000159 gelatin Polymers 0.000 claims abstract description 17
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
Abstract
The manufacturing of wound adhesive for the treatment of finger infections, including paronychia, which maintains the environment surrounding the wound sterile and, in addition to treating the infection, causes the healing of the underlying layers. An enzymatic approach is utilized to establish transverse connections between gelatin strands. For this, 41 microliters of 0.1% transglutaminase enzyme are added to the container per 1 ml of gelatin solution. Following mixing, the contents of the container are placed in an incubator for 64 hours to create the cross-links of the gelatin powder chains.
Description
The manufacturing of wound adhesive for the treatment of finger infections, including paronychia, which maintains the environment surrounding the wound sterile and, in addition to treating the infection, causes the healing of the underlying layers. An enzymatic approach is utilized to establish transverse connections between gelatin strands. For this, 41 microliters of 0.1% transglutaminase enzyme are added to the container per 1 ml of gelatin solution. Following mixing, the contents of the container are placed in an incubator for 64 hours to create the cross-links of the gelatin powder chains.
A61B17/54 - A61K36/19
A kind of paronychia therapy equipment
CN204683734U
The utility model discloses a kind of paronychia therapy equipment. Described paronychia therapy equipment comprises: shell fragment and fingernail hook, described shell fragment is arranged on above fingernail, and described shell fragment is bending along fingernail upper surface, the neck of hook of described fingernail hook is fixed on the end of shell fragment, described fingernail hook comprises the neck of hook and arc section, the neck of hook of described fingernail hook is connected with hook arc section, and the hook radian end of described fingernail hook is stuck in the both sides of fingernail lower end. Above-mentioned paronychia therapy equipment structure is simple, and low cost of manufacture, effectively can alleviate the slight illness of patient, and the rear recurrence probability of paronychia is less, does not affect the daily life of patient in therapeutic process.
Paronychia treatment device
CN104905854A
The invention discloses a paronychia treatment device. The paronychia treatment device comprises an elastic piece and fingernail hooks. The elastic piece is arranged on a fingernail and is bent along the upper end face of the fingernail; hook handles of the fingernail hooks are fixed to the ends of the elastic piece, each fingernail hook comprises the hook handle and an arc part, the hook handles of the fingernail hooks are connected with the hook arc parts, and the tail ends of the hook arcs of the fingernail hooks are clamped to the two sides of the lower end of the fingernail. The paronychia treatment device is simple in structure, low in manufacturing cost and capable of effectively relieving the pain of a patient, the recurrence probability is small after paronychia is cured, and the daily life of the patient is not affected in the treatment process.
Treatment of paronychia with indigo naturalis or indigo-producing plant extract
WO2016162493A1
A pharmaceutical or cosmetic composition comprising Indigo Naturalis or Indigo-producing plant extract for treating paronychia, and a method of treating paronychia comprising administering a therapeutically effective amount of Indigo Naturalis or Indigo-producing plant extract to a subject in need thereof are described.
Marine biological solution for treating onychomycosis and paronychia and preparation method thereof
CN103041374A
The invention discloses a marine biological solution for treating onychomycosis and paronychia and a preparation method thereof. The marine biological solution comprises the following components by weight percent: 1.5-2.5% of carboxymethyl chitosan, 3.0-4.0% of algal polysaccharide, 2.0-4.0% of mucopeptide-N-acetylmuramoylhydrolase, 6.0-9.0% of cecropin, 2.0-3.0% of glycerol, 1.0-4.0% of algae powder, and 73.5-84.5% of water. According to the invention, the marine biological solution for treating onychomycosis and paronychia is a non-toxic, colorless, odorless, non-irritant, non-corrosive and pollution-free green marine biological product, and has the advantages of convenience in use, high sterilization efficiency, wide bactericidal spectrum, high cure rate, short healing time and the like.
Traditional Chinese medicine liquid soap for preventing and treating finger paronychia
CN105194051A
The invention relates to traditional Chinese medicine liquid soap for preventing and treating finger paronychia and belongs to the technical field of traditional Chinese medicine disinfection washing products. The traditional Chinese medicine liquid soap for preventing and treating the finger paronychia comprises raw materials in parts by weight as follows: 8-12 parts of baical skullcap, 1-8 parts of houttuynia cordata, 1-8 parts of purslane, 2-10 parts of andrographis paniculata, 2-9 parts of rhizoma atractylodes, 21-26 parts of Lonicera japonica, 11-19 parts of weeping forsythia, 8-17 parts of dandelions, 4-12 parts of platycodon root, 5-12 parts of liquorice and 0.5-2 parts of gypsum. The traditional Chinese medicine liquid soap for preventing and treating the finger paronychia adopts the traditional Chinese medicines including the baical skullcap, the houttuynia cordata, the purslane and the like to be matched with other traditional Chinese medicine raw materials, has low cost and ideal effect, does not leave peculiar smell and has the efficacy of preventing the finger paronychia when used frequently.
This wound adhesive is used in the fields of pharmacy, medicine, cellular and molecular biology, and pharmacogenesis for the treatment of fingers such as paronychia. Paronychia are the most common cause of finger infections caused by opportunistic microorganisms. On the other hand, depending on the form and nature of the disease, one of the primary issues is to keep the disease sterile. In addition, there is no perfect treatment for this disease or they are very expensive and time-consuming. If this condition spreads, it may lead to catastrophic complications, including the amputation of a finger. Because of the presence of Verbascum plant extract, as well as cobalt, ascorbic acid, salicylic acid, and other substances, this composition not only heals the wound quickly and completely, but it also restores the lower layers of the skin and nails. On the other hand, because it is made in the form of a wound adhesive, it can keep the infected area sterile and prevent further contamination of the wound. Other benefits of this technology are its ease of manufacture and inexpensive cost.
Finger infections include a wide range of diseases, one of which is paronychia. Inflammation, chronic and continuous pain, progression of the disease to the underlying tissues and finally to the bone are serious threats of these diseases. On the other hand, the available drugs do not have a definitive and quick treatment for this disease. Another problem in treatment, repairing and healing such wounds is not keeping the wound environment sterile. Because these infections are mostly caused by opportunistic bacteria, keeping the environment sterile is one of the most important factors in the treatment of this disease. The main problem of paronychia is that this disease develops slowly and continuously, especially in people who are more exposed to water and tissues near the nail for any reason, and this problem is because the part of the cuticle barrier The tissue is destroyed. In order to solve this problem, the wound adhesive with plant extract Verbascum Thapsus can be used due to its antimicrobial properties and on a wide range of bacteria, including the bacteria responsible for paronychia. In addition, due to the presence of compounds such as cobalt and ascorbic acid in this adhesive, it causes complete healing of the wound, and due to the presence of salicylic acid, it increases the penetration power and cleans the skin surface, which generally causes healing in a short period of time, less than 5 days. On the other hand, due to the type of design of the product in the form of a wound patch, the environment around the wound is covered and any factors that increase the disease are prevented.
Paronychia is an important disease in the soft tissue around the nail. This is a common factor that everyone will face at some point in their life. The edge of the nail cuticle and the point where the nail attaches to the skin are common sites of paronychia. In this case, the skin around the nail becomes swollen, inflamed and painful, and sometimes abscesses with pus are seen. The most common causes of paronychia can be bacteria, fungi, and even viruses. All these factors can be present at the corner of the nail. This disease can have different symptoms, so that the disease caused by one agent progresses slowly and lasts a long time, while the disease of another agent progresses quickly and recurs within two to three days. If paronychia is treated, it will disappear and leave no traces on the nail. But if the disease is ignored it gets worse and a part of the patient is lost. Paronychia can involve more than one finger and can occur at any age. Band-aids containing the above ingredients are made to treat this disease and because of its naturalness, there is no danger to humans. This compound can be made and used in different forms, including wound dressings, ointments, and other medicinal forms. On the other hand, it can be placed in hydrogel pads, adhesive tapes, or any other type of dressing available. The use of this combination is also useful for repairing the underlying tissues of the skin and nails, which is one of the most important goals in this matter.
Saponin, mucilage, flavonoids, iridoids, phenylethanoid glycoside, monoterpene glucoside, steroid, spermine alkaloid, phenolic acid, fatty acid, tannin, carotene, neolignane glycosides, and other substances are found in the Verbascum plant. The presence of saponin and mucilage in the Verbascum plant contributes to its soothing and softening properties. The presence of phenolic chemicals in it also contributes to its anti-inflammatory and antimicrobial capabilities.
Methods and materials:
Plant extraction:
First, Verbascum Thapsus plant was extracted by hydroalcohol method. In this work, depending on the type of final processing, both the plant extract and the paste obtained from the plant itself can be used. If plant extract is used, it can be used on industrial hydrogels or animal hydrogels or any type of dressings.
Synthesis of hydrogels:
Gelatin hydrogel is manufactured at a concentration of 0.1% by weight to make industrial hydrogel. The gelatin powder is transported to a weighing scale and subjected to UV rays twice under the hood, then dissolved in distilled water for 30 minutes, according to the final volume. Transverse connections between gelatin strands are formed using an enzymatic technique. To do this, 41 microliters of 0.1% transglutaminase enzyme are added to the container per 1 ml of gelatin solution. Following mixing, the contents of the container are placed in an incubator for 64 hours to create the cross links of the gelatin powder chains.
For this, animal fat can be used instead of gelatin and animal-based hydrogel can be prepared. In this situation, after melting the animal fat and decreasing its temperature, which does not disrupt the structure of the elements in the composition, the ingredients are mixed with it, and it is then converted into a hydrogel using the standard procedures by adding enzymes, and it is loaded on the adhesive.
Composition:
The offered compositions are per size of 2 x 7 cm and thickness of one millimeter. As a result, any change in the desired adhesive's size must be added or decreased by the same proportion as the number of components.
The main components of this composition are 2% Verbascum Thapsus plant extract and 20% when used in the form of herbal paste, cobalt 0.01%, and ascorbic acid 0.05%. Calcium alginate, sodium carboxymethylcellulase (to alter rheology), and other common additions may be employed in varying percentages as basic components.
In addition, wound adhesives based on silica gel may be created.
In order to confirm the results, various tests were performed, including Antibiotic sensitivity testing. Then MIC&MBC test was done. In addition, the human test was also done with the consent of the person and the necessary permits.
In 96-well microtiter plates, the MIC&MBC (broth microdilution) test was carried out. To begin, 100 microliters of culture medium were added to all wells 2-12. Then, 100 microliters of plant extract were added to the first well, followed by 100 microliters of plant extract poured from the second well to the eleventh well of the microtiter plate. Finally, 100 microliters were taken from the eleventh well and discarded. The wells containing different dilutions of plant extract were then treated with 10 microliters of microbial suspension. Well number eleven containing culture medium and extract was considered as negative control and well number twelve containing culture medium and bacteria was considered as positive control.
Healing and rapid treatment of finger infections including paronychia.
Low production cost.
Effects in a very short period of time.
Use of herbal compounds as the main composition.
Keeping the wound area sterile due to the use of glue.
Production with indigenous knowledge.
No need for high technology and facilities in production.
High ability to penetrate the underlying layers and repair the underlying layers.
Possibility of production in different types of glue, ointment, poultice, etc. in different shapes and sizes.
Reducing treatment costs.
Easier to use for desired locations.
No need for special environmental conditions for storage and transportation.
This is the first time this work has been provided, and other pharmaceutical situations do not have the formulation in this manner and do not have the power of total recuperation. This ointment is safe for people since it is made from natural ingredients. This substance may be manufactured and utilized in plasters, ointments, and other therapeutic forms. It, on the other hand, may be loaded in hydrogel pads, regular wound adhesives, or any sorts of dressings, as previously mentioned. The use of additional substances to restore the lower layers of the skin and nails is the most essential concern here.
Table 1. Total estimation of flavonoid and phenol in methanolic, ethanolic, water, acetone and hexane extracts of the plant.
Estimation of total flavonoid and phenol in methanolic, ethanolic, water, acetone and hexane extracts. In this diagram, the x-axis represents the extracts in different solvents and the y-axis represents the flavonoid and phenol concentrations in ug/ml
| Diameter of halo of no growth (mm) | |||
| Dimethyl sulfoxide | Ciprofloxacin antibiotic |
Methanolic extract of the plant
Verbascum |
bacteria |
| 0 ± 6 | 2.5 ± 38.3 | 0.6 ± 25.8 | Staphylococcus aureus |
| 0 ± 6 | 1.1 ± 35.3 | 1.1 ± 18.6 | Bacillus cereus |
| 0 ± 6 | 1.5 ± 33.6 | 0 ± 6 | Escherichia coli |
Table 2. Mean and standard deviation of the halo diameter of non-growth of Verbascum plant extract by disk method.
Comparison of the mean and standard deviation shows that there is a significant difference between the methanolic extract of Verbascum plant, Bacillus cereus, Staphylococcus aureus and Escherichia coli on the diameter of the halo of non-growth in the disc method (p=0.0003). According to the obtained results, the extract of Verbascum plant showed a good antibacterial effect, especially for staph aureus. Staphylococcus aureus is considered to be one of the most important bacteria in the pathogenesis of paronychia and is therefore very important. They were chosen because of the difference in the cell wall of Gram-positive and negative bacteria and the hard permeability of the wall of Gram-negative bacteria to the external compounds of these bacteria. On the other hand, they were chosen because Staphylococcus aureus is one of the main causes of paronychia.
[Table. 3]
Table 3. Comparison of average antibacterial properties of Verbascum plant extract by disc diffusion method
| Diameter of halo of no growth (mm) | |||
| Dimethyl sulfoxide | Ciprofloxacin antibiotic |
Methanolic extract of the plant
Verbascum |
bacteria |
| 0 ± 6 | 3.9 ± 38 | 1.1 ± 24.8 | Staphylococcus aureus |
| 0 ± 6 | 3.1 ± 40.6 | 2.9 ± 13.8 | Bacillus cereus |
| 0 ± 6 | 2.2 ± 35 | 0 ± 6 | Escherichia coli |
Table 4. The mean and standard deviation of the halo diameter of Verbascum plant extract using the plate well method
[Table. 5]
Table 5. Comparison of the average antibacterial properties of Verbascum plant extract by well plate method.
Table 6 MIC and MBC of verbascum plant extract against staphylococcus aureus bacteria in terms
This combination has been formulated and manufactured in a laboratory setting, necessary laboratory tests have been performed, and a license for clinical trials has been requested. Because of the composition's relevance, it has been utilized to the consumer's pleasure, and the outcomes of usage have been quite satisfying.
Claims (6)
- The manufacturing of wound adhesive for the treatment of finger infections, including paronychia, which maintains the environment surrounding the wound sterile and, in addition to treating the infection, causes the healing of the underlying layers.
- According to claim 1, the Verbascum plant, scientifically known as Verbascum Thapsus, was extracted using the hydroalcoholic extraction technique, and depending on the kind of final processing, both the plant extract and the paste formed from the plant itself were employed. Plant extract may be employed on industrial hydrogels, animal hydrogels, and any sort of dressing.
- According to claim 2, gelatin hydrogel having a concentration of 0.1% by weight is created in order to generate industrial hydrogel.
- An enzymatic approach is utilized in claim 3 to establish transverse connections between gelatin strands. For this, 41 microliters of 0.1% transglutaminase enzyme are added to the container per 1 ml of gelatin solution. Following mixing, the contents of the container are placed in an incubator for 64 hours to create the cross links of the gelatin powder chains.
- According to claim 4, animal fat may be employed in place of gelatin in this design, and an animal-based hydrogel can be created. In this case, after melting the animal fat and lowering its temperature because it does not harm the structure of the ingredients in the composition, the ingredients are combined with it, then it is made into a hydrogel using the usual methods by adding enzymes, and then it is loaded on the adhesive. As a result, any change in the desired adhesive's size must be added or decreased by the same proportion as the number of components. This bandage may also be created using silica gel.
- According to claim 6, the principal component for this composition is 2% of the plant's extract, and 20% if employed in the form of a vegetable paste, cobalt 0.01%, and ascorbic acid 0.05%. Calcium alginate, sodium carboxymethylcellulase (to alter rheology), and other generic additions may be employed in small amounts for basic substances
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2023/053366 WO2024042374A1 (en) | 2023-04-03 | 2023-04-03 | Sticking plaster for treatment of finger infections such as paronychia |
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| PCT/IB2023/053366 WO2024042374A1 (en) | 2023-04-03 | 2023-04-03 | Sticking plaster for treatment of finger infections such as paronychia |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5724108B2 (en) * | 2009-04-22 | 2015-05-27 | メドスキン ソリューションズ ドクター ズベラック アーゲーＭｅｄＳｋｉｎ Ｓｏｌｕｔｉｏｎｓ Ｄｒ．Ｓｕｗｅｌａｃｋ ＡＧ | Lyophilized composition |
| WO2015009260A9 (en) * | 2013-07-16 | 2015-06-25 | Yeditepe Universitesi | A wound healing herbal product |
-
2023
- 2023-04-03 WO PCT/IB2023/053366 patent/WO2024042374A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5724108B2 (en) * | 2009-04-22 | 2015-05-27 | メドスキン ソリューションズ ドクター ズベラック アーゲーＭｅｄＳｋｉｎ Ｓｏｌｕｔｉｏｎｓ Ｄｒ．Ｓｕｗｅｌａｃｋ ＡＧ | Lyophilized composition |
| WO2015009260A9 (en) * | 2013-07-16 | 2015-06-25 | Yeditepe Universitesi | A wound healing herbal product |
Non-Patent Citations (1)
| Title |
|---|
| GANG YANG, XIAO ZHENGHUA, REN XIAOMEI, LONG HAIYAN, QIAN HONG, MA KUNLONG, GUO YINGQIANG: "Enzymatically crosslinked gelatin hydrogel promotes the proliferation of adipose tissue-derived stromal cells", PEERJ, vol. 4, 27 September 2016 (2016-09-27), pages E2497 - E2497-22, XP055588300, DOI: 10.7717/peerj.2497 * |
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