CN108703895B - Deep-permeation long-acting moisturizing gel and preparation method thereof - Google Patents
Deep-permeation long-acting moisturizing gel and preparation method thereof Download PDFInfo
- Publication number
- CN108703895B CN108703895B CN201810956924.7A CN201810956924A CN108703895B CN 108703895 B CN108703895 B CN 108703895B CN 201810956924 A CN201810956924 A CN 201810956924A CN 108703895 B CN108703895 B CN 108703895B
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- acid
- hyaluronic acid
- moisturizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 238000001879 gelation Methods 0.000 title description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 34
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 34
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 34
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 31
- 239000004626 polylactic acid Substances 0.000 claims abstract description 31
- 239000012510 hollow fiber Substances 0.000 claims abstract description 30
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 150000001412 amines Chemical class 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000835 fiber Substances 0.000 claims abstract description 26
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 21
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 21
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940041616 menthol Drugs 0.000 claims abstract description 21
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920001661 Chitosan Polymers 0.000 claims abstract description 20
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 20
- 229960001631 carbomer Drugs 0.000 claims abstract description 20
- 239000008367 deionised water Substances 0.000 claims abstract description 19
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 19
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims abstract description 18
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 18
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000001685 glycyrrhizic acid Substances 0.000 claims abstract description 18
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 18
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 18
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 18
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 18
- 239000001923 methylcellulose Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 18
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 18
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 18
- 239000011347 resin Substances 0.000 claims abstract description 18
- 229920005989 resin Polymers 0.000 claims abstract description 18
- 239000008117 stearic acid Substances 0.000 claims abstract description 18
- 239000004964 aerogel Substances 0.000 claims abstract description 8
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 8
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 4
- 239000012530 fluid Substances 0.000 claims description 25
- 239000002131 composite material Substances 0.000 claims description 24
- 235000010981 methylcellulose Nutrition 0.000 claims description 17
- 238000009489 vacuum treatment Methods 0.000 claims description 16
- 239000004965 Silica aerogel Substances 0.000 claims description 13
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 8
- 239000000084 colloidal system Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 2
- 230000005923 long-lasting effect Effects 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 34
- 230000000694 effects Effects 0.000 abstract description 7
- 210000002615 epidermis Anatomy 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 238000001467 acupuncture Methods 0.000 abstract description 2
- 238000011068 loading method Methods 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 32
- 239000000047 product Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 239000004909 Moisturizer Substances 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 210000000245 forearm Anatomy 0.000 description 4
- 230000001333 moisturizer Effects 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229940059958 centella asiatica extract Drugs 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229960005150 glycerol Drugs 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000008169 grapeseed oil Substances 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 240000000385 Brassica napus var. napus Species 0.000 description 1
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940048053 acrylate Drugs 0.000 description 1
- -1 alkyl glucoside Chemical class 0.000 description 1
- 239000001140 aloe barbadensis leaf extract Substances 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 229940069638 aloe vera leaf extract Drugs 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 229940071160 cocoate Drugs 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000010667 rosehip oil Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of skin care products, and provides a deep-permeation long-acting moisturizing gel and a preparation method thereof. The method comprises the steps of adsorbing hyaluronic acid by silicon dioxide aerogel and chitosan, loading the hyaluronic acid in hollow holes of polylactic acid hollow fibers, and further mixing with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methylcellulose, glycyrrhizic acid concentrated powder and deionized water to prepare the moisturizing gel. Compared with the traditional method, the moisturizing gel prepared by the invention utilizes the micro-acupuncture effect of the polylactic acid fibers on the skin to promote the carried hyaluronic acid to penetrate through the epidermis, promotes the skin to expand under the action of azone, menthol and organic amine, is beneficial to further permeation of the hyaluronic acid, realizes deep water replenishing and moisturizing, and has a slow release effect and can realize long-acting moisturizing because the hyaluronic acid is loaded in the hollow fibers.
Description
Technical Field
The invention belongs to the technical field of skin care products, and provides a deep-permeation long-acting moisturizing gel and a preparation method thereof.
Background
In the modern society, various pollutions are serious, the damage of the ecological environment has great influence on the skin of people, the skin is mainly yellowed, aged, dark in color, not glossy and the like, and even some people have serious color spots. Healthy skin should be smooth, moist, and elastic, and these appearance signs are related to the function of the skin's own moisturizing system. The moisturizing system functions to maintain a certain moisture content in the skin, and sufficient hydration facilitates enzymatic reactions and promotes stratum corneum maturation, maintaining stratum corneum elasticity. Therefore, moisturizing of the skin is also the basis of modern cosmetic skin care.
The external moisturizer in the moisturizing skin care product also has the effects of supplementing skin moisture, preventing excessive loss of moisture and keeping the health state of skin. The water content of the skin is 18-20% of the whole body, wherein the water is mainly stored in the dermis, the water content of the horny layer is only 15-30% of the epidermis, after the horny cells are fully hydrated, the horny cells help to maintain the appearance and the feeling characteristics of the skin, the skin is water-sensitive and elastic, and if the water content of the horny layer is lower than 10%, the skin is dried. Hyaluronic acid in a dermis mechanism is reduced, mucopolysaccharide is denatured, and contraction of blood vessels on an upper layer of dermis and reduction of permeability of blood vessel walls can cause reduction of water content in the dermis, so that skin is dry, dull, low in elasticity, high in wrinkles and other skin aging phenomena.
The raw materials of the moisturizing skin care product have the following characteristics: the moisture absorption capacity is strong; has proper viscosity; is colorless, non-toxic, non-irritant and non-erosive; has good solubility and is compatible with other substances; the appearance of the matrix is not damaged, and the oxidation is not easy to occur. The active ingredients in the moisturizing skin care products can be roughly divided into natural moisturizers and chemically synthesized moisturizers. Wherein the natural humectant contains natural components of human skin such as hyaluronic acid, ceramide, and glycerol, and also contains animal and plant extracts such as Mel, squalane, and Aloe extract; the chemically synthesized humectant comprises lactic acid, polyalcohol, sodium pyrrolidone carboxylate, chitosan and its derivatives. The application of gel skin care products containing moisturizers in skin care and moisturizing is particularly emphasized.
Chinese patent application No. 201711226810.9 discloses an aloe collagen moisturizing gel, and belongs to the technical field of daily chemicals. The moisturizing gel comprises the following components: deionized water, collagen, aloe vera leaf extract, centella asiatica extract, canola extract, glycerin, propylene glycol, acrylate, ethylhexyl glycerin, triethanolamine, butylene glycol, PEG-60 hydrogenated castor oil, PEG-40 hydrogenated castor oil, methylparaben, phenoxyethanol, gum, essence. The moisturizing gel takes various natural plant extracts such as collagen and aloe vera extract as main components, has excellent effects of supplementing moisture to skin and relieving skin problems, but has short moisturizing effect maintaining time and can not achieve long-acting moisturizing.
The Chinese patent application No. 201810112077.6 discloses a moisturizing gel emulsion and a preparation method thereof, wherein the moisturizing gel emulsion comprises the following raw materials: rose hip oil, centella asiatica extract, grape seed oil, vitamin E, isopropyl myristate, PEG-7 olive oil ester, lecithin, alkyl glucoside, sodium alginate, 1, 2-propylene glycol, water, stearyl alcohol, ethyl cellulose, sodium stearyl hyaluronate, butanediol cocoate, methyl p-hydroxybenzoate, xanthan gum, carbomer and citric acid. The preparation method comprises preparing emulsion from oleum Rosae Davuricae, herba Centellae extract, grapeseed oil, vitamin E and PEG-7 oleum Olivarum, and adding hydrogel matrix xanthan gum, xanthan gum and carbomer. The invention has the defects that the moisturizing component cannot deeply permeate and the slow release effect is not obvious.
In summary, in the cosmetics for moisturizing and skin caring in the prior art, the effective components such as hyaluronic acid and the like have poor slow release performance, are difficult to deeply permeate, so that the moisturizing effect is not ideal, and the moisturizing duration is short, so that the development of a skin care product capable of deeply permeating and long-acting moisturizing is of great significance.
Disclosure of Invention
Therefore, the moisturizing and skin-protecting gel cosmetic in the prior art has the defects of difficult deep penetration of effective components, short moisturizing effect maintaining time and the like. Aiming at the situation, a deep-permeation long-acting moisturizing gel and a preparation method thereof are provided, so that deep permeation and slow release of moisturizing active ingredients can be realized, and a good long-acting moisturizing effect is achieved.
In order to achieve the purpose, the invention relates to the following specific technical scheme:
a preparation method of a deep-permeation long-acting moisturizing gel comprises the following specific steps:
(1) mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers;
(3) and (3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and uniformly stirring to prepare the deep-penetrated long-acting moisturizing gel.
Preferably, in the colloidal fluid in the step (1), the low molecular weight hyaluronic acid is 55-70 parts by weight, the silica aerogel is 20-30 parts by weight, and the chitosan is 10-15 parts by weight.
Preferably, the molecular weight of the low molecular weight hyaluronic acid in the step (1) is 50-80 ten thousand.
Preferably, the specific surface area of the silica aerogel in the step (1) is 200-500 m2The pore size is 50-100 nm, and the porosity is 90-95%.
Preferably, the outer diameter of the polylactic acid hollow fiber in the step (2) is 0.4-0.8 mm, the wall thickness is 0.1-0.2 mm, and the length is 1-3 mm.
Preferably, the ultrasonic frequency of the ultrasonic dispersion in the step (2) is 40-60 kHz, and the power density is 0.5-0.8W/cm2The time is 20-50 min.
Preferably, the vacuum degree of the vacuum treatment in the step (2) is 10-50 Pa, and the treatment time is 20-40 min.
Preferably, in the moisturizing gel in the step (3), 22-25 parts by weight of composite fibers, 0.5-2 parts by weight of azone, 0.5-2 parts by weight of menthol, 1-2 parts by weight of organic amine, 2-4 parts by weight of stearic acid, 2-4 parts by weight of monoglyceride, 12-15 parts by weight of carbomer resin, 5-8 parts by weight of methylcellulose, 4-6 parts by weight of glycyrrhizic acid concentrated powder and 32-51 parts by weight of deionized water.
Preferably, the organic amine in step (3) is at least one of ethanolamine, diethanolamine and triethanolamine.
The invention also provides the deep-permeation long-acting moisturizing gel prepared by the preparation method. The long-acting moisturizing gel is prepared by adsorbing hyaluronic acid by silicon dioxide aerogel and chitosan, loading the hyaluronic acid in hollow holes of polylactic acid hollow fibers, and further mixing with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methylcellulose, glycyrrhizic acid concentrated powder and deionized water.
The invention provides a long-acting moisturizing gel with deep penetration and a preparation method thereof, compared with the prior art, the gel has the outstanding characteristics and excellent effects that:
1. the moisturizing gel prepared by the invention adsorbs hyaluronic acid by silicon dioxide aerogel and chitosan, and is loaded in the hollow holes of the polylactic acid hollow fibers, so that the hyaluronic acid is slowly released, the hyaluronic acid is prevented from being lost, and long-acting moisturizing is realized.
2. The moisturizing gel prepared by the invention carries hyaluronic acid through the polylactic acid hollow fiber, can promote hyaluronic acid to penetrate through epidermis by utilizing the micro-acupuncture effect of the polylactic acid fiber on skin, and provides a foundation for deep penetration.
3. The moisturizing gel prepared by the invention has the advantages that the skin is promoted to expand under the action of the azone, the menthol and the organic amine, effective substances are further promoted to reach the deep part of the skin, the deep penetration is realized, and the moisturizing effect and the durability are obviously improved.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments, but it should not be construed that the scope of the present invention is limited to the following examples. Various substitutions and alterations can be made by those skilled in the art and by conventional means without departing from the spirit of the method of the invention described above.
Example 1
(1) Mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid; 63 parts by weight of low-molecular-weight hyaluronic acid, 24 parts by weight of silica aerogel and 13 parts by weight of chitosan in the colloidal fluid;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers; the average outer diameter of the polylactic acid hollow fiber is 0.5mm, the average wall thickness is 0.1mm, and the average length is 2 mm; the ultrasonic frequency of the ultrasonic dispersion is 48kHz, and the power density is 0.7W/cm2The time is 30 min; the vacuum degree of the vacuum treatment is 30Pa, and the treatment is carried outThe time is 32 min;
(3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and stirring uniformly to obtain deep-layer permeable long-acting moisturizing gel; the organic amine is ethanolamine; in the moisturizing gel, 23 parts by weight of composite fiber, 1 part by weight of azone, 1 part by weight of menthol, 2 parts by weight of organic amine, 3 parts by weight of stearic acid, 3 parts by weight of monoglyceride, 13 parts by weight of carbomer resin, 7 parts by weight of methylcellulose, 5 parts by weight of glycyrrhizic acid concentrated powder and 42 parts by weight of deionized water.
Example 2
(1) Mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid; 70 parts of low-molecular-weight hyaluronic acid, 20 parts of silicon dioxide aerogel and 10 parts of chitosan in the colloidal fluid;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers; the average outer diameter of the polylactic acid hollow fiber is 0.4mm, the average wall thickness is 0.1mm, and the average length is 1 mm; the ultrasonic frequency of the ultrasonic dispersion is 40kHz, and the power density is 0.5W/cm2The time is 50 min; the vacuum degree of vacuum treatment is 10Pa, and the treatment time is 40 min;
(3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and stirring uniformly to obtain deep-layer permeable long-acting moisturizing gel; the organic amine is diethanolamine; in the moisturizing gel, 22 parts by weight of composite fibers, 0.5 part by weight of azone, 0.5 part by weight of menthol, 1 part by weight of organic amine, 2 parts by weight of stearic acid, 2 parts by weight of monoglyceride, 12 parts by weight of carbomer resin, 5 parts by weight of methyl cellulose, 4 parts by weight of glycyrrhizic acid concentrated powder and 51 parts by weight of deionized water.
Example 3
(1) Mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid; in the colloidal fluid, 55 parts by weight of low molecular weight hyaluronic acid, 30 parts by weight of silicon dioxide aerogel and 15 parts by weight of chitosan;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers; the average outer diameter of the polylactic acid hollow fiber is 0.8mm, the average wall thickness is 0.2mm, and the average length is 3 mm; the ultrasonic frequency of the ultrasonic dispersion is 60kHz, and the power density is 0.8W/cm2The time is 20 min; the vacuum degree of the vacuum treatment is 50Pa, and the treatment time is 20 min;
(3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and stirring uniformly to obtain deep-layer permeable long-acting moisturizing gel; the organic amine is triethanolamine; in the moisturizing gel, 5 parts by weight of composite fiber, 2 parts by weight of azone, 2 parts by weight of menthol, 2 parts by weight of organic amine, 4 parts by weight of stearic acid, 4 parts by weight of monoglyceride, 15 parts by weight of carbomer resin, 8 parts by weight of methylcellulose, 6 parts by weight of glycyrrhizic acid concentrated powder and 32 parts by weight of deionized water.
Example 4
(1) Mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid; 66 parts of low-molecular-weight hyaluronic acid, 22 parts of silicon dioxide aerogel and 12 parts of chitosan in the colloidal fluid;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers; the average outer diameter of the polylactic acid hollow fiber is 0.5mm, the average wall thickness is 0.1mm, and the average length is 1.5 mm; the ultrasonic frequency of the ultrasonic dispersion is 45kHz, and the power density is 0.6W/cm2The time is 40 min; the vacuum degree of vacuum treatment is 20Pa, and the treatment time is 35 min;
(3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and stirring uniformly to obtain deep-layer permeable long-acting moisturizing gel; the organic amine is ethanolamine; in the moisturizing gel, 23 parts by weight of composite fiber, 1 part by weight of azone, 1 part by weight of menthol, 1 part by weight of organic amine, 2 parts by weight of stearic acid, 3 parts by weight of monoglyceride, 13 parts by weight of carbomer resin, 6 parts by weight of methylcellulose, 4 parts by weight of glycyrrhizic acid concentrated powder and 46 parts by weight of deionized water.
Example 5
(1) Mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid; 59 parts by weight of low molecular weight hyaluronic acid, 27 parts by weight of silica aerogel and 14 parts by weight of chitosan in the colloidal fluid;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers; the average outer diameter of the polylactic acid hollow fiber is 0.7mm, the average wall thickness is 0.2mm, and the average length is 2.5 mm; the ultrasonic frequency of the ultrasonic dispersion is 55kHz, and the power density is 0.7W/cm2The time is 30 min; the vacuum degree of vacuum treatment is 40Pa, and the treatment time is 25 min;
(3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and stirring uniformly to obtain deep-layer permeable long-acting moisturizing gel; the organic amine is diethanolamine; in the moisturizing gel, 24 parts by weight of composite fiber, 1.5 parts by weight of azone, 1.5 parts by weight of menthol, 2 parts by weight of organic amine, 3 parts by weight of stearic acid, 4 parts by weight of monoglyceride, 14 parts by weight of carbomer resin, 7 parts by weight of methylcellulose, 6 parts by weight of glycyrrhizic acid concentrated powder and 37 parts by weight of deionized water.
Example 6
(1) Mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid; in the colloidal fluid, 62 parts by weight of low molecular weight hyaluronic acid, 25 parts by weight of silica aerogel and 13 parts by weight of chitosan;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers; the average outer diameter of the polylactic acid hollow fiber is 0.6mm, the average wall thickness is 0.2mm, and the average length is 2 mm; the ultrasonic frequency of the ultrasonic dispersion is 50kHz, and the power density is 0.6W/cm2The time is 35 min; the vacuum degree of vacuum treatment is 30Pa, and the treatment time is 30 min;
(3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and stirring uniformly to obtain deep-layer permeable long-acting moisturizing gel; the organic amine is triethanolamine; in the moisturizing gel, 24 parts by weight of composite fiber, 1 part by weight of azone, 1 part by weight of menthol, 2 parts by weight of organic amine, 3 parts by weight of stearic acid, 3 parts by weight of monoglyceride, 14 parts by weight of carbomer resin, 6 parts by weight of methylcellulose, 5 parts by weight of glycyrrhizic acid concentrated powder and 41 parts by weight of deionized water.
Comparative example 1
In the preparation process, the hyaluronic acid colloidal fluid is not loaded by polylactic acid hollow fiber, and other preparation conditions are consistent with those of example 6.
Comparative example 2
In the preparation process, azone, menthol and organic amine are not added, and other preparation conditions are consistent with those of example 6.
And (3) performance testing:
selecting 30 healthy volunteer subjects, 15 male subjects and 15 female subjects, wherein the age is 30-60 years, all the subjects have no history of skin or systemic diseases, the skin of a tested part (the inner side of an arm) has no abnormality, and external preparations such as external medicines, cosmetics and the like are not smeared; the temperature of the testing environment is kept at (22 +/-1) DEG C, the relative humidity is kept at 50 +/-5%, a volunteer needs to enter the testing environment in advance before testing, and the test is carried out for 30min (the temporary skin states of body surface temperature, emotion, sweat, grease secretion and the like are unified); selecting the position of the inner side of the left arm and the right arm of the subject, which is 5cm away from the base of the palm; defining several areas (4 cm × 4 cm) with the same area on the left forearm as the use area; points at the same position of the right forearm are used as blank control areas, and corresponding areas of the left forearm and the right forearm are tested simultaneously; smearing a sample on an arm experiment area of a subject; at 1h, 2h, 4h and 8h after application, the hydration status of the skin was tested using corneometer cm825, the water dispersion loss of the skin was tested using TewameterTM300, 5 measurements were made, and 5 measurements were taken and averaged; the blank control value is the average value of 5 relative values of hydration states and water loss values measured at the moment of 0 h; data obtained when 30 subjects applied the same sample were averaged.
The data obtained are shown in Table 1.
Table 1:
Claims (2)
1. a preparation method of a deep-permeation long-acting moisturizing gel is characterized in that the preparation method of the moisturizing gel comprises the following specific steps:
(1) mixing low molecular weight hyaluronic acid, silica aerogel and chitosan to prepare a colloid liquid; in the colloidal fluid, 55-70 parts by weight of low molecular weight hyaluronic acid, 20-30 parts by weight of silicon dioxide aerogel and 10-15 parts by weight of chitosan; the molecular weight of the low molecular weight hyaluronic acid is 50-80 ten thousand; the specific surface area of the silicon dioxide aerogel is 200-500 m2The pore size is 50-100 nm, and the porosity is 90-95%;
(2) adding polylactic acid hollow fibers into the colloidal fluid prepared in the step (1), uniformly dispersing by ultrasonic, and then carrying out vacuum treatment to fill the colloidal fluid into hollow holes of the polylactic acid hollow fibers to prepare composite fibers; the outer diameter of the polylactic acid hollow fiber is 0.4-0.8 mm, the wall thickness is 0.1-0.2 mm, and the length is 1-3 mm; the ultrasonic frequency of the ultrasonic dispersion is 40-60 kHz, and the power density is 0.5-0.8W/cm2The time is 20-50 min; the vacuum degree of the vacuum treatment is 10-50 PaThe treatment time is 20-40 min;
(3) mixing the composite fiber prepared in the step (2) with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer resin, methyl cellulose, glycyrrhizic acid concentrated powder and deionized water, and stirring uniformly to obtain deep-layer permeable long-acting moisturizing gel; in the moisturizing gel, 22-25 parts by weight of composite fibers, 0.5-2 parts by weight of azone, 0.5-2 parts by weight of menthol, 1-2 parts by weight of organic amine, 2-4 parts by weight of stearic acid, 2-4 parts by weight of monoglyceride, 12-15 parts by weight of carbomer resin, 5-8 parts by weight of methyl cellulose, 4-6 parts by weight of glycyrrhizic acid concentrated powder and 32-51 parts by weight of deionized water; the organic amine is at least one of ethanolamine, diethanolamine and triethanolamine.
2. A deep penetrating long lasting moisturizing gel prepared according to the method of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810956924.7A CN108703895B (en) | 2018-08-21 | 2018-08-21 | Deep-permeation long-acting moisturizing gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810956924.7A CN108703895B (en) | 2018-08-21 | 2018-08-21 | Deep-permeation long-acting moisturizing gel and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108703895A CN108703895A (en) | 2018-10-26 |
| CN108703895B true CN108703895B (en) | 2021-02-09 |
Family
ID=63873744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810956924.7A Active CN108703895B (en) | 2018-08-21 | 2018-08-21 | Deep-permeation long-acting moisturizing gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108703895B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991348B (en) * | 2020-09-01 | 2023-07-25 | 江西省科达动物药业有限公司 | Doramectin slow-release microcapsule injection |
| CN112999119A (en) * | 2021-03-24 | 2021-06-22 | 蒋涛 | Gel-like cosmetic with lasting moisturizing function and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1445311A (en) * | 2002-03-20 | 2003-10-01 | 新加坡纳米材料科技有限公司 | calcium carbonate/silicon dioxide-water(1/n) nano-compound particle and hollow silicon dioxide-water(1/n) nano-material and its preparation method |
| CN104707241A (en) * | 2015-03-25 | 2015-06-17 | 北京化工大学 | Two-stage-type micro-needle array and preparation method thereof |
| CN104994881A (en) * | 2013-02-13 | 2015-10-21 | 久光制药株式会社 | Microneedle-coating composition and microneedle device |
| CN105078880A (en) * | 2015-09-12 | 2015-11-25 | 北京化工大学 | Macromolecular soluble microneedle used for cutaneous penetration of polypeptide and protein medicines and preparation method of macromolecular soluble microneedle |
| CN105663023A (en) * | 2016-01-22 | 2016-06-15 | 江汉大学 | Method for preparing light-control medicine releasing micro-needles |
| CN107405301A (en) * | 2015-03-27 | 2017-11-28 | 利奥制药有限公司 | For to the microneedle patch of dermal delivery active component |
| CN108158993A (en) * | 2018-01-12 | 2018-06-15 | 连云港本草美汇医药科技有限公司 | A kind of removing acnes and controlling oil micro emulsion gels and preparation method and application |
| CN108186522A (en) * | 2018-02-28 | 2018-06-22 | 陈彦彪 | A kind of solubility is dispelled striae of pregnancy micropin and preparation method thereof |
| CN108837148A (en) * | 2018-07-20 | 2018-11-20 | 成都新柯力化工科技有限公司 | A kind of insulin cutaneous penetration patch and preparation method for diabetes |
-
2018
- 2018-08-21 CN CN201810956924.7A patent/CN108703895B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1445311A (en) * | 2002-03-20 | 2003-10-01 | 新加坡纳米材料科技有限公司 | calcium carbonate/silicon dioxide-water(1/n) nano-compound particle and hollow silicon dioxide-water(1/n) nano-material and its preparation method |
| CN104994881A (en) * | 2013-02-13 | 2015-10-21 | 久光制药株式会社 | Microneedle-coating composition and microneedle device |
| CN104707241A (en) * | 2015-03-25 | 2015-06-17 | 北京化工大学 | Two-stage-type micro-needle array and preparation method thereof |
| CN107405301A (en) * | 2015-03-27 | 2017-11-28 | 利奥制药有限公司 | For to the microneedle patch of dermal delivery active component |
| CN105078880A (en) * | 2015-09-12 | 2015-11-25 | 北京化工大学 | Macromolecular soluble microneedle used for cutaneous penetration of polypeptide and protein medicines and preparation method of macromolecular soluble microneedle |
| CN105663023A (en) * | 2016-01-22 | 2016-06-15 | 江汉大学 | Method for preparing light-control medicine releasing micro-needles |
| CN108158993A (en) * | 2018-01-12 | 2018-06-15 | 连云港本草美汇医药科技有限公司 | A kind of removing acnes and controlling oil micro emulsion gels and preparation method and application |
| CN108186522A (en) * | 2018-02-28 | 2018-06-22 | 陈彦彪 | A kind of solubility is dispelled striae of pregnancy micropin and preparation method thereof |
| CN108837148A (en) * | 2018-07-20 | 2018-11-20 | 成都新柯力化工科技有限公司 | A kind of insulin cutaneous penetration patch and preparation method for diabetes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108703895A (en) | 2018-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104666236B (en) | A kind of preserving moisture and protecting skin facial film | |
| US6274155B1 (en) | Nonwoven sheet and film containing water absorbent keratin | |
| US6461628B1 (en) | Non-woven keratin cell scaffold | |
| CN103637952B (en) | Mask liquid for whitening hydrating mask paste and preparation method and application thereof | |
| CN104434768A (en) | Moisturizing lotion with slow-release efficacy and preparation method of moisturizing lotion | |
| WO2014044808A2 (en) | Fast-penetration cosmetic dermal filler for topical application | |
| CN113208968B (en) | Whitening and moisturizing essence and preparation method thereof | |
| CN108703895B (en) | Deep-permeation long-acting moisturizing gel and preparation method thereof | |
| CN104983647A (en) | Deep restoration mask and making method thereof | |
| KR20150011260A (en) | Beauty kit containing cosmetic composition and patch, and method for beauty | |
| CN108852963A (en) | A kind of microneedle patch and preparation method thereof for replenishing water and preserving moisture | |
| CN104146879A (en) | Anti-aging double-face mask and preparation methods of mask essence liquid | |
| CN105963239A (en) | Emulsion capable of promoting skin to regenerate | |
| CN102988200B (en) | Liposome face-nourishing skin care product | |
| CN114259419B (en) | Compound composition containing recombinant collagen and preparation method and application thereof | |
| CN109044941A (en) | A kind of skin-tightening nourishes moisture-keeping composition and its preparation method and application | |
| KR101895037B1 (en) | Hydrogel comprising spicule and use thereof | |
| WO2000057836A3 (en) | Cosmetic or dermatological compositions containing at least one substance for increasing the functionality and/or expression of cd44 membrane receptors of skin cells | |
| CN102988257A (en) | Liposome sun-screening skin care product | |
| CN112274447A (en) | Dendrobium officinale polysaccharide-hyaluronic acid soluble microneedle and preparation method thereof | |
| KR20210116191A (en) | Cosmetic composition comprising natural extracts as an effective component | |
| CN104922007A (en) | Wrinkle-removal essence | |
| KR20190040845A (en) | Cosmetic composition for moisturizing containing Saururus chinensis fermented extract | |
| KR101436819B1 (en) | Cosmetic composition for moisturing, soothing skin and improving acne | |
| KR102368309B1 (en) | Mask pack composition for improved moisturizing effect |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210121 Address after: Room 1401, building 1, No.2, Dagang Road, chebei, Tianhe District, Guangzhou, Guangdong 510630 Applicant after: Guangzhou xiangpulan e-commerce Co.,Ltd. Address before: No.816, Longcheng Avenue, Longquanyi District, Chengdu, Sichuan 610100 Applicant before: Zhao Hongwei |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231113 Address after: Room 501, No. 145 Dongyi Road, Donghuan Street, Panyu District, Guangzhou City, Guangdong Province, 510000 Patentee after: Guangdong Hanxiang E-commerce Co.,Ltd. Address before: Room 1401, building 1, No.2, Dagang Road, chebei, Tianhe District, Guangzhou, Guangdong 510630 Patentee before: Guangzhou xiangpulan e-commerce Co.,Ltd. |
|
| TR01 | Transfer of patent right |